Compile Data Set for Download or QSAR
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Found 7 Enz. Inhib. hit(s) with all data for entry = 8521
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM255476(US10125100, Example 1 | US10392346, Example 1 | US...)
Affinity DataIC50:  5nMAssay Description:The inhibitory activities of the compound of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM255476(US10125100, Example 1 | US10392346, Example 1 | US...)
Affinity DataIC50:  11nMAssay Description:Method 2: This method follows the same steps as Method 1 below, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM255476(US10125100, Example 1 | US10392346, Example 1 | US...)
Affinity DataIC50:  14nMAssay Description:The inhibitory activities of the compound of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM255476(US10125100, Example 1 | US10392346, Example 1 | US...)
Affinity DataIC50:  115nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM255476(US10125100, Example 1 | US10392346, Example 1 | US...)
Affinity DataKd:  7.10nMAssay Description:Kinase enzyme binding activities of the compound disclosed herein may be determined using a proprietary assay which measures active site-directed com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
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US Patent
LigandPNGBDBM255476(US10125100, Example 1 | US10392346, Example 1 | US...)
Affinity DataKd:  4.20nMAssay Description:Kinase enzyme binding activities of the compound disclosed herein may be determined using a proprietary assay which measures active site-directed com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM255476(US10125100, Example 1 | US10392346, Example 1 | US...)
Affinity DataKd:  2.80nMAssay Description:Kinase enzyme binding activities of the compound disclosed herein may be determined using a proprietary assay which measures active site-directed com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent