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Patent code US9499493

Compile Data Set for Download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255524
PNG
(N4-[(2,2-Difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]...)
Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)=C1
Show InChI InChI=1S/C22H21F3N6O4/c1-11-3-4-13(8-17(11)34-10-18(32)26-2)29-21-27-9-14(23)19(31-21)28-12-5-6-16-15(7-12)30-20(33)22(24,25)35-16/h5-9H,3-4,10H2,1-2H3,(H,26,32)(H,30,33)(H2,27,28,29,31)
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n/an/a 0.450n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255515
PNG
(US9499493, R950368)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCC(N)c4c3)n2)c1
Show InChI InChI=1S/C22H23FN6O3/c1-25-20(30)12-32-15-4-2-3-13(9-15)28-22-26-11-17(23)21(29-22)27-14-5-6-19-16(10-14)18(24)7-8-31-19/h2-6,9-11,18H,7-8,12,24H2,1H3,(H,25,30)(H2,26,27,28,29)
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n/an/a 10.7n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255514
PNG
(US9499493, R921304)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4n3)n2)c1
Show InChI InChI=1S/C20H18FN7O4/c1-22-16(29)9-31-12-4-2-3-11(7-12)24-20-23-8-13(21)18(28-20)25-15-6-5-14-19(26-15)27-17(30)10-32-14/h2-8H,9-10H2,1H3,(H,22,29)(H3,23,24,25,26,27,28,30)
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n/an/a 12.8n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255518
PNG
((+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenox...)
Show SMILES COC1=CCCC(Nc2ncc(F)c(Nc3ccc4OC(C)CNc4c3)n2)=C1NC(C)=O
Show InChI InChI=1S/C22H25FN6O3/c1-12-10-24-17-9-14(7-8-18(17)32-12)27-21-15(23)11-25-22(29-21)28-16-5-4-6-19(31-3)20(16)26-13(2)30/h6-9,11-12,24H,4-5,10H2,1-3H3,(H,26,30)(H2,25,27,28,29)
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n/an/a 24n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255508
PNG
(US9499493, R935302)
Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12
Show InChI InChI=1S/C22H21FN6O3/c23-17-13-24-22(27-15-2-4-18-14(10-15)12-25-29(18)6-1-7-30)28-21(17)26-16-3-5-19-20(11-16)32-9-8-31-19/h2-5,10-13,30H,1,6-9H2,(H2,24,26,27,28)
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n/an/a 26.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255513
PNG
(US9499493, R940338)
Show SMILES Cn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OC(C)(C)C(=O)Nc5c4)n3)ccc12
Show InChI InChI=1S/C22H20FN7O2/c1-22(2)20(31)28-16-9-14(5-7-18(16)32-22)26-19-15(23)11-24-21(29-19)27-13-4-6-17-12(8-13)10-25-30(17)3/h4-11H,1-3H3,(H,28,31)(H2,24,26,27,29)
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n/an/a 28n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255525
PNG
(N4-[(2,2-Dimethyl-4H-5-pyrido[1,4]oxazin-3-one)-6-...)
Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)=C1
Show InChI InChI=1S/C23H26FN7O4/c1-12-5-6-13(9-16(12)34-11-18(32)25-4)27-22-26-10-14(24)19(31-22)28-17-8-7-15-20(29-17)30-21(33)23(2,3)35-15/h7-10H,5-6,11H2,1-4H3,(H,25,32)(H3,26,27,28,29,30,31,33)
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n/an/a 34.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255501
PNG
(US9499493, R908702)
Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc4OCC(=O)Nc4c3)n2)c1
Show InChI InChI=1S/C18H14FN5O3/c19-13-8-20-18(22-10-2-1-3-12(25)6-10)24-17(13)21-11-4-5-15-14(7-11)23-16(26)9-27-15/h1-8,25H,9H2,(H,23,26)(H2,20,21,22,24)
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n/an/a 37.8n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255509
PNG
(US9499493, R935304)
Show SMILES OCCCn1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12
Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)10-14)25-15-5-6-18-13(9-15)11-23-27(18)7-2-8-28/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)
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n/an/a 42n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255488
PNG
(US9499493, R935191)
Show SMILES Oc1cccc(Nc2nc(Nc3ccc4cn[nH]c4c3)ncc2F)c1
Show InChI InChI=1S/C17H13FN6O/c18-14-9-19-17(22-12-5-4-10-8-20-24-15(10)7-12)23-16(14)21-11-2-1-3-13(25)6-11/h1-9,25H,(H,20,24)(H2,19,21,22,23)
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n/an/a 45n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255506
PNG
(US9499493, R935237)
Show SMILES COC(=O)Cn1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12
Show InChI InChI=1S/C20H17FN6O3/c1-30-18(29)11-27-17-6-5-14(7-12(17)9-23-27)25-20-22-10-16(21)19(26-20)24-13-3-2-4-15(28)8-13/h2-10,28H,11H2,1H3,(H2,22,24,25,26)
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n/an/a 45.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255487
PNG
(US9499493, R935190)
Show SMILES Fc1cnc(Nc2ccc3cn[nH]c3c2)nc1Nc1ccc2OCCOc2c1
Show InChI InChI=1S/C19H15FN6O2/c20-14-10-21-19(24-12-2-1-11-9-22-26-15(11)7-12)25-18(14)23-13-3-4-16-17(8-13)28-6-5-27-16/h1-4,7-10H,5-6H2,(H,22,26)(H2,21,23,24,25)
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n/an/a 46.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255507
PNG
(US9499493, R935293)
Show SMILES OCCCn1ncc2ccc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)cc12
Show InChI InChI=1S/C20H19FN6O2/c21-17-12-22-20(26-19(17)24-14-3-1-4-16(29)9-14)25-15-6-5-13-11-23-27(7-2-8-28)18(13)10-15/h1,3-6,9-12,28-29H,2,7-8H2,(H2,22,24,25,26)
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n/an/a 46.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255505
PNG
(US9499493, R926839)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(C)c(Cl)c3)n2)c1
Show InChI InChI=1S/C20H19ClFN5O2/c1-12-6-7-14(9-16(12)21)25-19-17(22)10-24-20(27-19)26-13-4-3-5-15(8-13)29-11-18(28)23-2/h3-10H,11H2,1-2H3,(H,23,28)(H2,24,25,26,27)
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n/an/a 55n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255510
PNG
(US9499493, R935307)
Show SMILES CC(C)Oc1ccc(Nc2nc(Nc3ccc4n(CCCO)ncc4c3)ncc2F)cc1
Show InChI InChI=1S/C23H25FN6O2/c1-15(2)32-19-7-4-17(5-8-19)27-22-20(24)14-25-23(29-22)28-18-6-9-21-16(12-18)13-26-30(21)10-3-11-31/h4-9,12-15,31H,3,10-11H2,1-2H3,(H2,25,27,28,29)
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n/an/a 57n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255485
PNG
(US9499493, R926816)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1
Show InChI InChI=1S/C21H20FN5O4/c1-23-19(28)12-31-15-4-2-3-13(9-15)26-21-24-11-16(22)20(27-21)25-14-5-6-17-18(10-14)30-8-7-29-17/h2-6,9-11H,7-8,12H2,1H3,(H,23,28)(H2,24,25,26,27)
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n/an/a 61.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255523
PNG
(N4-[(2,2-Dimethyl-4H-benzo[1,4]oxazin-3-one)-6-yl]...)
Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4c3)n2)=C1
Show InChI InChI=1S/C24H27FN6O4/c1-13-5-6-15(10-19(13)34-12-20(32)26-4)29-23-27-11-16(25)21(31-23)28-14-7-8-18-17(9-14)30-22(33)24(2,3)35-18/h7-11H,5-6,12H2,1-4H3,(H,26,32)(H,30,33)(H2,27,28,29,31)
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n/an/a 62n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255526
PNG
(N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N...)
Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3cccc(c3)C(=O)NOC)n2)=C1
Show InChI InChI=1S/C22H25FN6O4/c1-13-7-8-16(10-18(13)33-12-19(30)24-2)27-22-25-11-17(23)20(28-22)26-15-6-4-5-14(9-15)21(31)29-32-3/h4-6,9-11H,7-8,12H2,1-3H3,(H,24,30)(H,29,31)(H2,25,26,27,28)
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n/an/a 66.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255477
PNG
(US9499493, R926505)
Show SMILES OCCNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1
Show InChI InChI=1S/C22H22FN5O5/c23-17-12-25-22(27-14-2-1-3-16(10-14)33-13-20(30)24-6-7-29)28-21(17)26-15-4-5-18-19(11-15)32-9-8-31-18/h1-5,10-12,29H,6-9,13H2,(H,24,30)(H2,25,26,27,28)
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n/an/a 70.3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255489
PNG
(US9499493, R935193)
Show SMILES Cn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12
Show InChI InChI=1S/C20H17FN6O2/c1-27-16-4-2-13(8-12(16)10-23-27)25-20-22-11-15(21)19(26-20)24-14-3-5-17-18(9-14)29-7-6-28-17/h2-5,8-11H,6-7H2,1H3,(H2,22,24,25,26)
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n/an/a 75n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255481
PNG
(US9499493, R926745)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4cc[nH]c4c3)n2)c1
Show InChI InChI=1S/C21H19FN6O2/c1-23-19(29)12-30-16-4-2-3-14(9-16)27-21-25-11-17(22)20(28-21)26-15-6-5-13-7-8-24-18(13)10-15/h2-11,24H,12H2,1H3,(H,23,29)(H2,25,26,27,28)
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n/an/a 92.5n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255511
PNG
(US9499493, R935309)
Show SMILES CNC(=O)CCn1ncc2cc(Nc3ncc(F)c(Nc4ccc5OCCOc5c4)n3)ccc12
Show InChI InChI=1S/C23H22FN7O3/c1-25-21(32)6-7-31-18-4-2-15(10-14(18)12-27-31)29-23-26-13-17(24)22(30-23)28-16-3-5-19-20(11-16)34-9-8-33-19/h2-5,10-13H,6-9H2,1H3,(H,25,32)(H2,26,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255519
PNG
(5-Fluoro-N4-(3-hydroxy-4-methylphenyl)-N2-[3-[(N-m...)
Show SMILES CNC(=O)COC1=CCCC(Nc2ncc(F)c(Nc3ccc(C)c(O)c3)n2)=C1
Show InChI InChI=1S/C20H22FN5O3/c1-12-6-7-14(9-17(12)27)24-19-16(21)10-23-20(26-19)25-13-4-3-5-15(8-13)29-11-18(28)22-2/h5-10,27H,3-4,11H2,1-2H3,(H,22,28)(H2,23,24,25,26)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255482
PNG
(US9499493, R926782)
Show SMILES OCC(O)CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)c1
Show InChI InChI=1S/C23H24FN5O6/c24-18-11-26-23(29-22(18)27-15-4-5-19-20(9-15)34-7-6-33-19)28-14-2-1-3-17(8-14)35-13-21(32)25-10-16(31)12-30/h1-5,8-9,11,16,30-31H,6-7,10,12-13H2,(H,25,32)(H2,26,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255502
PNG
(US9499493, R909268)
Show SMILES Oc1cccc(Nc2nc(Nc3ccc4OCC(=O)Nc4c3)ncc2F)c1
Show InChI InChI=1S/C18H14FN5O3/c19-13-8-20-18(24-17(13)21-10-2-1-3-12(25)6-10)22-11-4-5-15-14(7-11)23-16(26)9-27-15/h1-8,25H,9H2,(H,23,26)(H2,20,21,22,24)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255495
PNG
(US9499493, R940276)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3cccc(c3)C(C)(C)C)n2)c1
Show InChI InChI=1S/C23H26FN5O2/c1-23(2,3)15-7-5-8-16(11-15)27-21-19(24)13-26-22(29-21)28-17-9-6-10-18(12-17)31-14-20(30)25-4/h5-13H,14H2,1-4H3,(H,25,30)(H2,26,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255478
PNG
(US9499493, R926508)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C19H18FN5O3/c1-21-17(27)11-28-15-7-3-5-13(9-15)24-19-22-10-16(20)18(25-19)23-12-4-2-6-14(26)8-12/h2-10,26H,11H2,1H3,(H,21,27)(H2,22,23,24,25)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255503
PNG
(US9499493, R920410)
Show SMILES CNC(=O)COC1=CCCC(Nc2ncc(F)c(Nc3ccc(c(Cl)c3)C(F)(F)F)n2)=C1
Show InChI InChI=1S/C20H18ClF4N5O2/c1-26-17(31)10-32-13-4-2-3-11(7-13)29-19-27-9-16(22)18(30-19)28-12-5-6-14(15(21)8-12)20(23,24)25/h4-9H,2-3,10H2,1H3,(H,26,31)(H2,27,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255490
PNG
(US9499493, R935194)
Show SMILES Cn1ncc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc12
Show InChI InChI=1S/C18H15FN6O/c1-25-16-6-5-13(7-11(16)9-21-25)23-18-20-10-15(19)17(24-18)22-12-3-2-4-14(26)8-12/h2-10,26H,1H3,(H2,20,22,23,24)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255521
PNG
(N4-(3-Chloro-4-methoxyphenyl)-5-fluoro-N2-[3-[(N-m...)
Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc(OC)c(Cl)c3)n2)=C1
Show InChI InChI=1S/C21H23ClFN5O3/c1-12-4-5-14(9-18(12)31-11-19(29)24-2)27-21-25-10-16(23)20(28-21)26-13-6-7-17(30-3)15(22)8-13/h6-10H,4-5,11H2,1-3H3,(H,24,29)(H2,25,26,27,28)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255497
PNG
(US9499493, R940290)
Show SMILES CC(C)c1cccc(Nc2nc(Nc3cccc(OCC(=O)NCC(O)CO)c3)ncc2F)c1
Show InChI InChI=1S/C24H28FN5O4/c1-15(2)16-5-3-6-17(9-16)28-23-21(25)12-27-24(30-23)29-18-7-4-8-20(10-18)34-14-22(33)26-11-19(32)13-31/h3-10,12,15,19,31-32H,11,13-14H2,1-2H3,(H,26,33)(H2,27,28,29,30)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255512
PNG
(US9499493, R935310)
Show SMILES CNC(=O)CCn1ncc2cc(Nc3ncc(F)c(Nc4ccc(OC(C)C)cc4)n3)ccc12
Show InChI InChI=1S/C24H26FN7O2/c1-15(2)34-19-7-4-17(5-8-19)29-23-20(25)14-27-24(31-23)30-18-6-9-21-16(12-18)13-28-32(21)11-10-22(33)26-3/h4-9,12-15H,10-11H2,1-3H3,(H,26,33)(H2,27,29,30,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255483
PNG
(US9499493, R926791)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)cc(OC)c1
Show InChI InChI=1S/C20H19FN4O4/c1-26-14-7-13(8-15(10-14)27-2)24-20-22-11-16(21)19(25-20)23-12-3-4-17-18(9-12)29-6-5-28-17/h3-4,7-11H,5-6H2,1-2H3,(H2,22,23,24,25)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255496
PNG
(US9499493, R940277)
Show SMILES CC(C)(C)c1cccc(Nc2nc(Nc3cccc(OCC(=O)NCC(O)CO)c3)ncc2F)c1
Show InChI InChI=1S/C25H30FN5O4/c1-25(2,3)16-6-4-7-17(10-16)29-23-21(26)13-28-24(31-23)30-18-8-5-9-20(11-18)35-15-22(34)27-12-19(33)14-32/h4-11,13,19,32-33H,12,14-15H2,1-3H3,(H,27,34)(H2,28,29,30,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255486
PNG
(US9499493, R935138)
Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc(OCc4nc(no4)-c4ccccc4)cc3)n2)c1
Show InChI InChI=1S/C25H19FN6O3/c26-21-14-27-25(29-18-7-4-8-19(33)13-18)31-24(21)28-17-9-11-20(12-10-17)34-15-22-30-23(32-35-22)16-5-2-1-3-6-16/h1-14,33H,15H2,(H2,27,28,29,31)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255522
PNG
(5-Fluoro-N4-[(1H)-indol-5-yl]-N2-[3-[(N-methylamin...)
Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4[nH]ccc4c3)n2)=C1
Show InChI InChI=1S/C22H23FN6O2/c1-13-3-4-16(10-19(13)31-12-20(30)24-2)28-22-26-11-17(23)21(29-22)27-15-5-6-18-14(9-15)7-8-25-18/h5-11,25H,3-4,12H2,1-2H3,(H,24,30)(H2,26,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255516
PNG
(N2-[3-(1-Bis(N-methylaminocarbonyl)ethoxy)phenyl]-...)
Show SMILES CNC(=O)N(C(C)OC1CC(Nc2ncc(F)c(Nc3ccc(OC(C)C)cc3)n2)=CC=C1)C(=O)NC
Show InChI InChI=1S/C25H32FN7O4/c1-15(2)36-19-11-9-17(10-12-19)30-22-21(26)14-29-23(32-22)31-18-7-6-8-20(13-18)37-16(3)33(24(34)27-4)25(35)28-5/h6-12,14-16,20H,13H2,1-5H3,(H,27,34)(H,28,35)(H2,29,30,31,32)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255517
PNG
(N2,N4-Bis(3-aminophenyl)-5-fluoro-2,4-pyrimidinedi...)
Show SMILES Nc1cccc(c1)N(c1cccc(N)c1)c1ncc(F)c(n1)N(c1cccc(N)c1)c1cccc(N)c1
Show InChI InChI=1S/C28H25FN8/c29-26-17-34-28(37(24-11-3-7-20(32)15-24)25-12-4-8-21(33)16-25)35-27(26)36(22-9-1-5-18(30)13-22)23-10-2-6-19(31)14-23/h1-17H,30-33H2
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255504
PNG
(US9499493, R926834)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(OC)c(O)c3)n2)c1
Show InChI InChI=1S/C20H20FN5O4/c1-22-18(28)11-30-14-5-3-4-12(8-14)25-20-23-10-15(21)19(26-20)24-13-6-7-17(29-2)16(27)9-13/h3-10,27H,11H2,1-2H3,(H,22,28)(H2,23,24,25,26)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255500
PNG
(US9499493, R945144)
Show SMILES OCCOc1ccc(Nc2ncc(F)c(Nc3ccc4OCCOc4c3)n2)cc1
Show InChI InChI=1S/C20H19FN4O4/c21-16-12-22-20(24-13-1-4-15(5-2-13)27-8-7-26)25-19(16)23-14-3-6-17-18(11-14)29-10-9-28-17/h1-6,11-12,26H,7-10H2,(H2,22,23,24,25)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255484
PNG
(US9499493, R926813)
Show SMILES Fc1cnc(Nc2cccc(c2)-c2cnco2)nc1Nc1ccc2OCCOc2c1
Show InChI InChI=1S/C21H16FN5O3/c22-16-10-24-21(26-14-3-1-2-13(8-14)19-11-23-12-30-19)27-20(16)25-15-4-5-17-18(9-15)29-7-6-28-17/h1-5,8-12H,6-7H2,(H2,24,25,26,27)
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n/an/a 405n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068779
PNG
(CHEMBL3402397 | US9499493, R945071)
Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc(OCC#N)cc3)n2)c1
Show InChI InChI=1S/C18H14FN5O2/c19-16-11-21-18(23-13-2-1-3-14(25)10-13)24-17(16)22-12-4-6-15(7-5-12)26-9-8-20/h1-7,10-11,25H,9H2,(H2,21,22,23,24)
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US Patent
n/an/a 430n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255520
PNG
(5-Fluoro-N4-(3-hydroxyphenyl)-N2-[4-methyl-3-[(N-m...)
Show SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3cccc(O)c3)n2)=C1
Show InChI InChI=1S/C20H22FN5O3/c1-12-6-7-14(9-17(12)29-11-18(28)22-2)25-20-23-10-16(21)19(26-20)24-13-4-3-5-15(27)8-13/h3-5,8-10,27H,6-7,11H2,1-2H3,(H,22,28)(H2,23,24,25,26)
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n/an/a 510n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255480
PNG
(US9499493, R926715)
Show SMILES CC(C)(CO)NC(=O)c1cc2cc(Nc3ncc(F)c(Nc4cccc(O)c4)n3)ccc2o1
Show InChI InChI=1S/C23H22FN5O4/c1-23(2,12-30)29-21(32)19-9-13-8-15(6-7-18(13)33-19)27-22-25-11-17(24)20(28-22)26-14-4-3-5-16(31)10-14/h3-11,30-31H,12H2,1-2H3,(H,29,32)(H2,25,26,27,28)
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n/an/a 534n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255498
PNG
(US9499493, R945140)
Show SMILES Cc1cc(Nc2nc(Nc3cccc(OCC(=O)N4CCNCC4)c3)ncc2F)cc(C)c1O
Show InChI InChI=1S/C24H27FN6O3/c1-15-10-18(11-16(2)22(15)33)28-23-20(25)13-27-24(30-23)29-17-4-3-5-19(12-17)34-14-21(32)31-8-6-26-7-9-31/h3-5,10-13,26,33H,6-9,14H2,1-2H3,(H2,27,28,29,30)
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n/an/a 611n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255493
PNG
(US9499493, R940269)
Show SMILES Cc1cc(Nc2nc(Nc3cccc(OCCN4CCOCC4)c3)ncc2F)cc(Cl)c1O
Show InChI InChI=1S/C23H25ClFN5O3/c1-15-11-17(13-19(24)21(15)31)27-22-20(25)14-26-23(29-22)28-16-3-2-4-18(12-16)33-10-7-30-5-8-32-9-6-30/h2-4,11-14,31H,5-10H2,1H3,(H2,26,27,28,29)
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n/an/a 685n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255494
PNG
(US9499493, R940275)
Show SMILES CC(C)(C)C(=O)Nc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C21H22FN5O2/c1-21(2,3)19(29)25-13-6-4-7-14(10-13)26-20-23-12-17(22)18(27-20)24-15-8-5-9-16(28)11-15/h4-12,28H,1-3H3,(H,25,29)(H2,23,24,26,27)
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n/an/a 734n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255479
PNG
(US9499493, R926594)
Show SMILES Fc1cnc(Nc2ccc3cc[nH]c3c2)nc1Nc1ccc2cc[nH]c2c1
Show InChI InChI=1S/C20H15FN6/c21-16-11-24-20(26-15-4-2-13-6-8-23-18(13)10-15)27-19(16)25-14-3-1-12-5-7-22-17(12)9-14/h1-11,22-23H,(H2,24,25,26,27)
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n/an/a 771n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255491
PNG
(US9499493, R940255 | US9499493, R940256)
Show SMILES Cc1cc(Nc2nc(Nc3cccc(OCCN4CCOCC4)c3)ncc2F)cc(C)c1O
Show InChI InChI=1S/C24H28FN5O3/c1-16-12-19(13-17(2)22(16)31)27-23-21(25)15-26-24(29-23)28-18-4-3-5-20(14-18)33-11-8-30-6-9-32-10-7-30/h3-5,12-15,31H,6-11H2,1-2H3,(H2,26,27,28,29)
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n/an/a 771n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255499
PNG
(US9499493, R945142)
Show SMILES Cc1cc(Nc2nc(Nc3cccc(OCCN4CCNCC4)c3)ncc2F)cc(C)c1O
Show InChI InChI=1S/C24H29FN6O2/c1-16-12-19(13-17(2)22(16)32)28-23-21(25)15-27-24(30-23)29-18-4-3-5-20(14-18)33-11-10-31-8-6-26-7-9-31/h3-5,12-15,26,32H,6-11H2,1-2H3,(H2,27,28,29,30)
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n/an/a 2.01E+3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM255491
PNG
(US9499493, R940255 | US9499493, R940256)
Show SMILES Cc1cc(Nc2nc(Nc3cccc(OCCN4CCOCC4)c3)ncc2F)cc(C)c1O
Show InChI InChI=1S/C24H28FN5O3/c1-16-12-19(13-17(2)22(16)31)27-23-21(25)15-26-24(29-23)28-18-4-3-5-20(14-18)33-11-8-30-6-9-32-10-7-30/h3-5,12-15,31H,6-11H2,1-2H3,(H2,26,27,28,29)
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n/an/a 2.79E+3n/an/an/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%