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Patent code US9499547

Compile Data Set for Download or QSAR
Found 110 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259295
PNG
(US9499547, 36)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-13-2-1-3-15-12(13)8-16(25-15)14-9-21-17-4-5-18(22-23(14)17)24-11-6-10(20)7-11/h1-5,8-11H,6-7,20H2/t10-,11-
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n/an/a 1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259295
PNG
(US9499547, 36)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-13-2-1-3-15-12(13)8-16(25-15)14-9-21-17-4-5-18(22-23(14)17)24-11-6-10(20)7-11/h1-5,8-11H,6-7,20H2/t10-,11-
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n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259298
PNG
(US9499547, 39)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(F)ccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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n/an/a 3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259297
PNG
(US9499547, 38)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(O[C@H]3C[C@H](N)C3)nn12
Show InChI InChI=1S/C19H18N4O3/c1-24-13-2-3-16-11(6-13)7-17(26-16)15-10-21-18-4-5-19(22-23(15)18)25-14-8-12(20)9-14/h2-7,10,12,14H,8-9,20H2,1H3/t12-,14-
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n/an/a 3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259260
PNG
(US9499547, 1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCCN)nn12
Show InChI InChI=1S/C19H20N4O3/c1-24-15-5-4-6-16-13(15)11-17(26-16)14-12-21-18-7-8-19(22-23(14)18)25-10-3-2-9-20/h4-8,11-12H,2-3,9-10,20H2,1H3
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n/an/a 3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259279
PNG
(US9499547, 20)
Show SMILES NC[C@H]1CC(C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-10-12-7-14(8-12)24-19-6-5-18-21-11-15(23(18)22-19)17-9-13-3-1-2-4-16(13)25-17/h1-6,9,11-12,14H,7-8,10,20H2/t12-,14?
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259262
PNG
(US9499547, 3)
Show SMILES N[C@H]1C[C@H](C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c19-12-8-13(9-12)23-18-6-5-17-20-10-14(22(17)21-18)16-7-11-3-1-2-4-15(11)24-16/h1-7,10,12-13H,8-9,19H2/t12-,13+
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259296
PNG
(US9499547, 37)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C18H15ClN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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n/an/a 4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259260
PNG
(US9499547, 1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCCN)nn12
Show InChI InChI=1S/C19H20N4O3/c1-24-15-5-4-6-16-13(15)11-17(26-16)14-12-21-18-7-8-19(22-23(14)18)25-10-3-2-9-20/h4-8,11-12H,2-3,9-10,20H2,1H3
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n/an/a 5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259296
PNG
(US9499547, 37)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C18H15ClN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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n/an/a 5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259261
PNG
(US9499547, 2)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c19-12-8-13(9-12)23-18-6-5-17-20-10-14(22(17)21-18)16-7-11-3-1-2-4-15(11)24-16/h1-7,10,12-13H,8-9,19H2/t12-,13-
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259263
PNG
(US9499547, 4)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCN)nn12
Show InChI InChI=1S/C18H18N4O3/c1-23-14-4-2-5-15-12(14)10-16(25-15)13-11-20-17-6-7-18(21-22(13)17)24-9-3-8-19/h2,4-7,10-11H,3,8-9,19H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259281
PNG
(US9499547, 22)
Show SMILES N[C@H]1C[C@H](COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)C1
Show InChI InChI=1S/C19H18N4O2/c20-14-7-12(8-14)11-24-19-6-5-18-21-10-15(23(18)22-19)17-9-13-3-1-2-4-16(13)25-17/h1-6,9-10,12,14H,7-8,11,20H2/t12-,14-
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259279
PNG
(US9499547, 20)
Show SMILES NC[C@H]1CC(C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-10-12-7-14(8-12)24-19-6-5-18-21-11-15(23(18)22-19)17-9-13-3-1-2-4-16(13)25-17/h1-6,9,11-12,14H,7-8,10,20H2/t12-,14?
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259264
PNG
(US9499547, 5)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCN)nn12
Show InChI InChI=1S/C17H16N4O3/c1-22-13-3-2-4-14-11(13)9-15(24-14)12-10-19-16-5-6-17(20-21(12)16)23-8-7-18/h2-6,9-10H,7-8,18H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259265
PNG
(US9499547, 6)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCN)nn12
Show InChI InChI=1S/C17H16N4O3/c1-22-12-2-3-14-11(8-12)9-15(24-14)13-10-19-16-4-5-17(20-21(13)16)23-7-6-18/h2-5,8-10H,6-7,18H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259276
PNG
(US9499547, 17)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c23-17(15-6-2-1-3-7-15)14-27-22-11-10-21-24-13-18(26(21)25-22)20-12-16-8-4-5-9-19(16)28-20/h1-13,17H,14,23H2/t17-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259298
PNG
(US9499547, 39)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(F)ccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259261
PNG
(US9499547, 2)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c19-12-8-13(9-12)23-18-6-5-17-20-10-14(22(17)21-18)16-7-11-3-1-2-4-15(11)24-16/h1-7,10,12-13H,8-9,19H2/t12-,13-
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259297
PNG
(US9499547, 38)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(O[C@H]3C[C@H](N)C3)nn12
Show InChI InChI=1S/C19H18N4O3/c1-24-13-2-3-16-11(6-13)7-17(26-16)15-10-21-18-4-5-19(22-23(15)18)25-14-8-12(20)9-14/h2-7,10,12,14H,8-9,20H2,1H3/t12-,14-
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259284
PNG
(US9499547, 25)
Show SMILES N[C@H]1CCC[C@H]1Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-13-5-3-7-16(13)25-19-9-8-18-21-11-14(23(18)22-19)17-10-12-4-1-2-6-15(12)24-17/h1-2,4,6,8-11,13,16H,3,5,7,20H2/t13-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259266
PNG
(US9499547, 7)
Show SMILES C[C@H](N)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(18)10-22-17-7-6-16-19-9-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-9,11H,10,18H2,1H3/t11-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259267
PNG
(US9499547, 8)
Show SMILES NCCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c19-9-3-4-10-23-18-8-7-17-20-12-14(22(17)21-18)16-11-13-5-1-2-6-15(13)24-16/h1-2,5-8,11-12H,3-4,9-10,19H2
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n/an/a 7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259268
PNG
(US9499547, 9)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCCN)nn12
Show InChI InChI=1S/C18H18N4O3/c1-23-13-3-4-15-12(9-13)10-16(25-15)14-11-20-17-5-6-18(21-22(14)17)24-8-2-7-19/h3-6,9-11H,2,7-8,19H2,1H3
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n/an/a 7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259269
PNG
(US9499547, 10)
Show SMILES CC(C)(CCN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O2/c1-19(2,9-10-20)25-18-8-7-17-21-12-14(23(17)22-18)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10,20H2,1-2H3
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n/an/a 8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259270
PNG
(US9499547, 11)
Show SMILES NCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c18-8-3-9-22-17-7-6-16-19-11-13(21(16)20-17)15-10-12-4-1-2-5-14(12)23-15/h1-2,4-7,10-11H,3,8-9,18H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259299
PNG
(US9499547, 40)
Show SMILES CC(CN)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c1-12(9-19)11-23-18-7-6-17-20-10-14(22(17)21-18)16-8-13-4-2-3-5-15(13)24-16/h2-8,10,12H,9,11,19H2,1H3
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n/an/a 9n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259283
PNG
(US9499547, 24)
Show SMILES N[C@H]1CCC[C@@H]1Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-13-5-3-7-16(13)25-19-9-8-18-21-11-14(23(18)22-19)17-10-12-4-1-2-6-15(12)24-17/h1-2,4,6,8-11,13,16H,3,5,7,20H2/t13-,16-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259271
PNG
(US9499547, 12)
Show SMILES NCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C16H14N4O2/c17-7-8-21-16-6-5-15-18-10-12(20(15)19-16)14-9-11-3-1-2-4-13(11)22-14/h1-6,9-10H,7-8,17H2
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n/an/a 10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259276
PNG
(US9499547, 17)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c23-17(15-6-2-1-3-7-15)14-27-22-11-10-21-24-13-18(26(21)25-22)20-12-16-8-4-5-9-19(16)28-20/h1-13,17H,14,23H2/t17-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259300
PNG
(US9499547, 41)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCC(N)C3CC3)nn12
Show InChI InChI=1S/C20H20N4O3/c1-25-16-3-2-4-17-13(16)9-18(27-17)15-10-22-19-7-8-20(23-24(15)19)26-11-14(21)12-5-6-12/h2-4,7-10,12,14H,5-6,11,21H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259265
PNG
(US9499547, 6)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCN)nn12
Show InChI InChI=1S/C17H16N4O3/c1-22-12-2-3-14-11(8-12)9-15(24-14)13-10-19-16-4-5-17(20-21(13)16)23-7-6-18/h2-5,8-10H,6-7,18H2,1H3
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n/an/a 13n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259280
PNG
(US9499547, 21)
Show SMILES NCCOCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O3/c19-7-8-23-9-10-24-18-6-5-17-20-12-14(22(17)21-18)16-11-13-3-1-2-4-15(13)25-16/h1-6,11-12H,7-10,19H2
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n/an/a 14n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259272
PNG
(US9499547, 13)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(9-18)22-17-7-6-16-19-10-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-8,10-11H,9,18H2,1H3/t11-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259263
PNG
(US9499547, 4)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCN)nn12
Show InChI InChI=1S/C18H18N4O3/c1-23-14-4-2-5-15-12(14)10-16(25-15)13-11-20-17-6-7-18(21-22(13)17)24-9-3-8-19/h2,4-7,10-11H,3,8-9,19H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259301
PNG
(US9499547, 42)
Show SMILES C[C@@H](N)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(18)10-22-17-7-6-16-19-9-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-9,11H,10,18H2,1H3/t11-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259285
PNG
(US9499547, 26)
Show SMILES NCC(Cc1ccccc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H20N4O2/c24-14-18(12-16-6-2-1-3-7-16)28-23-11-10-22-25-15-19(27(22)26-23)21-13-17-8-4-5-9-20(17)29-21/h1-11,13,15,18H,12,14,24H2
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n/an/a 15n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259314
PNG
(US9499547, 55)
Show SMILES NC[C@H](Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1
Show InChI InChI=1S/C21H17N5O2/c22-11-19(15-5-3-9-23-12-15)28-21-8-7-20-24-13-16(26(20)25-21)18-10-14-4-1-2-6-17(14)27-18/h1-10,12-13,19H,11,22H2/t19-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259304
PNG
(US9499547, 45)
Show SMILES C[C@H](N)COc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1
Show InChI InChI=1S/C17H15FN4O2/c1-10(19)9-23-17-6-5-16-20-8-13(22(16)21-17)15-7-11-12(18)3-2-4-14(11)24-15/h2-8,10H,9,19H2,1H3/t10-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259311
PNG
(US9499547, 52)
Show SMILES NCC(COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C23H20N4O2/c24-13-18(16-6-2-1-3-7-16)15-28-23-11-10-22-25-14-19(27(22)26-23)21-12-17-8-4-5-9-20(17)29-21/h1-12,14,18H,13,15,24H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259281
PNG
(US9499547, 22)
Show SMILES N[C@H]1C[C@H](COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)C1
Show InChI InChI=1S/C19H18N4O2/c20-14-7-12(8-14)11-24-19-6-5-18-21-10-15(23(18)22-19)17-9-13-3-1-2-4-16(13)25-17/h1-6,9-10,12,14H,7-8,11,20H2/t12-,14-
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n/an/a 17n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259262
PNG
(US9499547, 3)
Show SMILES N[C@H]1C[C@H](C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c19-12-8-13(9-12)23-18-6-5-17-20-10-14(22(17)21-18)16-7-11-3-1-2-4-15(11)24-16/h1-7,10,12-13H,8-9,19H2/t12-,13+
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n/an/a 17n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259267
PNG
(US9499547, 8)
Show SMILES NCCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c19-9-3-4-10-23-18-8-7-17-20-12-14(22(17)21-18)16-11-13-5-1-2-6-15(13)24-16/h1-2,5-8,11-12H,3-4,9-10,19H2
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n/an/a 17n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259288
PNG
(US9499547, 29)
Show SMILES CC(C)(N)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c1-18(2,19)11-23-17-8-7-16-20-10-13(22(16)21-17)15-9-12-5-3-4-6-14(12)24-15/h3-10H,11,19H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259264
PNG
(US9499547, 5)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCN)nn12
Show InChI InChI=1S/C17H16N4O3/c1-22-13-3-2-4-14-11(13)9-15(24-14)12-10-19-16-5-6-17(20-21(12)16)23-8-7-18/h2-6,9-10H,7-8,18H2,1H3
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259282
PNG
(US9499547, 23)
Show SMILES N[C@@H]1CCCC[C@H]1Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c21-14-6-2-4-8-17(14)26-20-10-9-19-22-12-15(24(19)23-20)18-11-13-5-1-3-7-16(13)25-18/h1,3,5,7,9-12,14,17H,2,4,6,8,21H2/t14-,17-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259266
PNG
(US9499547, 7)
Show SMILES C[C@H](N)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(18)10-22-17-7-6-16-19-9-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-9,11H,10,18H2,1H3/t11-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259299
PNG
(US9499547, 40)
Show SMILES CC(CN)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c1-12(9-19)11-23-18-7-6-17-20-10-14(22(17)21-18)16-8-13-4-2-3-5-15(13)24-16/h2-8,10,12H,9,11,19H2,1H3
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259313
PNG
(US9499547, 54)
Show SMILES NCC(Cc1ccncc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C22H19N5O2/c23-13-17(11-15-7-9-24-10-8-15)28-22-6-5-21-25-14-18(27(21)26-22)20-12-16-3-1-2-4-19(16)29-20/h1-10,12,14,17H,11,13,23H2
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n/an/a 19n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259283
PNG
(US9499547, 24)
Show SMILES N[C@H]1CCC[C@@H]1Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-13-5-3-7-16(13)25-19-9-8-18-21-11-14(23(18)22-19)17-10-12-4-1-2-6-15(12)24-17/h1-2,4,6,8-11,13,16H,3,5,7,20H2/t13-,16-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259273
PNG
(US9499547, 14)
Show SMILES CC(C)(N)CCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O2/c1-19(2,20)9-10-24-18-8-7-17-21-12-14(23(17)22-18)16-11-13-5-3-4-6-15(13)25-16/h3-8,11-12H,9-10,20H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259317
PNG
(US9499547, 58)
Show SMILES CC(C)Oc1cccc(c1)C(CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C25H24N4O3/c1-16(2)30-19-8-5-7-17(12-19)23(14-26)32-25-11-10-24-27-15-20(29(24)28-25)22-13-18-6-3-4-9-21(18)31-22/h3-13,15-16,23H,14,26H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259268
PNG
(US9499547, 9)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCCN)nn12
Show InChI InChI=1S/C18H18N4O3/c1-23-13-3-4-15-12(9-13)10-16(25-15)14-11-20-17-5-6-18(21-22(14)17)24-8-2-7-19/h3-6,9-11H,2,7-8,19H2,1H3
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n/an/a 22n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259277
PNG
(US9499547, 18)
Show SMILES N[C@@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c23-17(15-6-2-1-3-7-15)14-27-22-11-10-21-24-13-18(26(21)25-22)20-12-16-8-4-5-9-19(16)28-20/h1-13,17H,14,23H2/t17-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259284
PNG
(US9499547, 25)
Show SMILES N[C@H]1CCC[C@H]1Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-13-5-3-7-16(13)25-19-9-8-18-21-11-14(23(18)22-19)17-10-12-4-1-2-6-15(12)24-17/h1-2,4,6,8-11,13,16H,3,5,7,20H2/t13-,16+/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259270
PNG
(US9499547, 11)
Show SMILES NCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c18-8-3-9-22-17-7-6-16-19-11-13(21(16)20-17)15-10-12-4-1-2-5-14(12)23-15/h1-2,4-7,10-11H,3,8-9,18H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259278
PNG
(US9499547, 19)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H17ClN4O2/c23-16-6-7-19-15(10-16)11-20(29-19)18-12-25-21-8-9-22(26-27(18)21)28-13-17(24)14-4-2-1-3-5-14/h1-12,17H,13,24H2/t17-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259285
PNG
(US9499547, 26)
Show SMILES NCC(Cc1ccccc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H20N4O2/c24-14-18(12-16-6-2-1-3-7-16)28-23-11-10-22-25-15-19(27(22)26-23)21-13-17-8-4-5-9-20(17)29-21/h1-11,13,15,18H,12,14,24H2
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n/an/a 25n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259275
PNG
(US9499547, 16)
Show SMILES NC[C@H](Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c23-13-20(15-6-2-1-3-7-15)28-22-11-10-21-24-14-17(26(21)25-22)19-12-16-8-4-5-9-18(16)27-19/h1-12,14,20H,13,23H2/t20-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259271
PNG
(US9499547, 12)
Show SMILES NCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C16H14N4O2/c17-7-8-21-16-6-5-15-18-10-12(20(15)19-16)14-9-11-3-1-2-4-13(11)22-14/h1-6,9-10H,7-8,17H2
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n/an/a 27n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259300
PNG
(US9499547, 41)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCC(N)C3CC3)nn12
Show InChI InChI=1S/C20H20N4O3/c1-25-16-3-2-4-17-13(16)9-18(27-17)15-10-22-19-7-8-20(23-24(15)19)26-11-14(21)12-5-6-12/h2-4,7-10,12,14H,5-6,11,21H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259309
PNG
(US9499547, 50)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)Cc1ccccc1
Show InChI InChI=1S/C23H20N4O2/c24-18(12-16-6-2-1-3-7-16)15-28-23-11-10-22-25-14-19(27(22)26-23)21-13-17-8-4-5-9-20(17)29-21/h1-11,13-14,18H,12,15,24H2/t18-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259310
PNG
(US9499547, 51)
Show SMILES NC1(COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)CC1
Show InChI InChI=1S/C18H16N4O2/c19-18(7-8-18)11-23-17-6-5-16-20-10-13(22(16)21-17)15-9-12-3-1-2-4-14(12)24-15/h1-6,9-10H,7-8,11,19H2
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n/an/a 29n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259320
PNG
(US9499547, 61)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(F)cc1
Show InChI InChI=1S/C22H17FN4O2/c23-16-7-5-14(6-8-16)17(24)13-28-22-10-9-21-25-12-18(27(21)26-22)20-11-15-3-1-2-4-19(15)29-20/h1-12,17H,13,24H2/t17-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259286
PNG
(US9499547, 27)
Show SMILES NC1(COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)CCC1
Show InChI InChI=1S/C19H18N4O2/c20-19(8-3-9-19)12-24-18-7-6-17-21-11-14(23(17)22-18)16-10-13-4-1-2-5-15(13)25-16/h1-2,4-7,10-11H,3,8-9,12,20H2
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n/an/a 29n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259311
PNG
(US9499547, 52)
Show SMILES NCC(COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C23H20N4O2/c24-13-18(16-6-2-1-3-7-16)15-28-23-11-10-22-25-14-19(27(22)26-23)21-12-17-8-4-5-9-20(17)29-21/h1-12,14,18H,13,15,24H2
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n/an/a 30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259269
PNG
(US9499547, 10)
Show SMILES CC(C)(CCN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O2/c1-19(2,9-10-20)25-18-8-7-17-21-12-14(23(17)22-18)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10,20H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259321
PNG
(US9499547, 62)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H17ClN4O2/c23-16-7-5-14(6-8-16)17(24)13-28-22-10-9-21-25-12-18(27(21)26-22)20-11-15-3-1-2-4-19(15)29-20/h1-12,17H,13,24H2/t17-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259292
PNG
(US9499547, 33)
Show SMILES CC(C)CC(CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H22N4O2/c1-13(2)9-15(11-21)25-20-8-7-19-22-12-16(24(19)23-20)18-10-14-5-3-4-6-17(14)26-18/h3-8,10,12-13,15H,9,11,21H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259294
PNG
(US9499547, 35)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CCOC1
Show InChI InChI=1S/C20H20N4O3/c21-10-18(14-7-8-25-12-14)27-20-6-5-19-22-11-15(24(19)23-20)17-9-13-3-1-2-4-16(13)26-17/h1-6,9,11,14,18H,7-8,10,12,21H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259277
PNG
(US9499547, 18)
Show SMILES N[C@@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c23-17(15-6-2-1-3-7-15)14-27-22-11-10-21-24-13-18(26(21)25-22)20-12-16-8-4-5-9-19(16)28-20/h1-13,17H,14,23H2/t17-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259302
PNG
(US9499547, 43)
Show SMILES C[C@@H](N)COc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C17H15ClN4O2/c1-10(19)9-23-17-5-4-16-20-8-13(22(16)21-17)15-7-11-6-12(18)2-3-14(11)24-15/h2-8,10H,9,19H2,1H3/t10-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259272
PNG
(US9499547, 13)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(9-18)22-17-7-6-16-19-10-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-8,10-11H,9,18H2,1H3/t11-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259305
PNG
(US9499547, 46)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H17FN4O2/c23-16-7-4-8-19-15(16)11-20(29-19)18-12-25-21-9-10-22(26-27(18)21)28-13-17(24)14-5-2-1-3-6-14/h1-12,17H,13,24H2/t17-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259274
PNG
(US9499547, 15)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C17H15ClN4O2/c1-10(8-19)23-17-5-4-16-20-9-13(22(16)21-17)15-7-11-6-12(18)2-3-14(11)24-15/h2-7,9-10H,8,19H2,1H3/t10-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259318
PNG
(US9499547, 59)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)16-6-3-5-14(10-16)20(12-27)32-22-9-8-21-28-13-17(30(21)29-22)19-11-15-4-1-2-7-18(15)31-19/h1-11,13,20H,12,27H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259306
PNG
(US9499547, 47)
Show SMILES C[C@@H](CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(9-18)22-17-7-6-16-19-10-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-8,10-11H,9,18H2,1H3/t11-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259273
PNG
(US9499547, 14)
Show SMILES CC(C)(N)CCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O2/c1-19(2,20)9-10-24-18-8-7-17-21-12-14(23(17)22-18)16-11-13-5-3-4-6-15(13)25-16/h3-8,11-12H,9-10,20H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259319
PNG
(US9499547, 60)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(F)cc1F
Show InChI InChI=1S/C22H16F2N4O2/c23-14-5-6-15(16(24)10-14)20(11-25)30-22-8-7-21-26-12-17(28(21)27-22)19-9-13-3-1-2-4-18(13)29-19/h1-10,12,20H,11,25H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259293
PNG
(US9499547, 34)
Show SMILES NCC(CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H17N5O2/c18-8-12(9-19)23-17-6-5-16-20-10-13(22(16)21-17)15-7-11-3-1-2-4-14(11)24-15/h1-7,10,12H,8-9,18-19H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259315
PNG
(US9499547, 56)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(F)cc1
Show InChI InChI=1S/C22H17FN4O2/c23-16-7-5-14(6-8-16)20(12-24)29-22-10-9-21-25-13-17(27(21)26-22)19-11-15-3-1-2-4-18(15)28-19/h1-11,13,20H,12,24H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259289
PNG
(US9499547, 30)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CC1
Show InChI InChI=1S/C19H18N4O2/c20-10-17(12-5-6-12)25-19-8-7-18-21-11-14(23(18)22-19)16-9-13-3-1-2-4-15(13)24-16/h1-4,7-9,11-12,17H,5-6,10,20H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259301
PNG
(US9499547, 42)
Show SMILES C[C@@H](N)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(18)10-22-17-7-6-16-19-9-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-9,11H,10,18H2,1H3/t11-/m1/s1
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n/an/a 43n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259287
PNG
(US9499547, 28)
Show SMILES NCC(CCC=C)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c1-2-3-7-15(12-21)25-20-10-9-19-22-13-16(24(19)23-20)18-11-14-6-4-5-8-17(14)26-18/h2,4-6,8-11,13,15H,1,3,7,12,21H2
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n/an/a 45n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259312
PNG
(US9499547, 53)
Show SMILES NCC(Cc1ccc(F)cc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H19FN4O2/c24-17-7-5-15(6-8-17)11-18(13-25)29-23-10-9-22-26-14-19(28(22)27-23)21-12-16-3-1-2-4-20(16)30-21/h1-10,12,14,18H,11,13,25H2
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n/an/a 46n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259275
PNG
(US9499547, 16)
Show SMILES NC[C@H](Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c23-13-20(15-6-2-1-3-7-15)28-22-11-10-21-24-14-17(26(21)25-22)19-12-16-8-4-5-9-18(16)27-19/h1-12,14,20H,13,23H2/t20-/m0/s1
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n/an/a 49n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259294
PNG
(US9499547, 35)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CCOC1
Show InChI InChI=1S/C20H20N4O3/c21-10-18(14-7-8-25-12-14)27-20-6-5-19-22-11-15(24(19)23-20)17-9-13-3-1-2-4-16(13)26-17/h1-6,9,11,14,18H,7-8,10,12,21H2
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n/an/a 52n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259303
PNG
(US9499547, 44)
Show SMILES NCC1(COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)COC1
Show InChI InChI=1S/C19H18N4O3/c20-9-19(10-24-11-19)12-25-18-6-5-17-21-8-14(23(17)22-18)16-7-13-3-1-2-4-15(13)26-16/h1-8H,9-12,20H2
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n/an/a 52n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259309
PNG
(US9499547, 50)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)Cc1ccccc1
Show InChI InChI=1S/C23H20N4O2/c24-18(12-16-6-2-1-3-7-16)15-28-23-11-10-22-25-14-19(27(22)26-23)21-13-17-8-4-5-9-20(17)29-21/h1-11,13-14,18H,12,15,24H2/t18-/m0/s1
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n/an/a 54n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259322
PNG
(US9499547, 63)
Show SMILES NC(COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1
Show InChI InChI=1S/C21H17N5O2/c22-16(15-5-3-9-23-11-15)13-27-21-8-7-20-24-12-17(26(20)25-21)19-10-14-4-1-2-6-18(14)28-19/h1-12,16H,13,22H2
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n/an/a 54n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259323
PNG
(US9499547, 64)
Show SMILES NCCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccc(F)cc1
Show InChI InChI=1S/C23H19FN4O2/c24-17-7-5-15(6-8-17)20(11-12-25)30-23-10-9-22-26-14-18(28(22)27-23)21-13-16-3-1-2-4-19(16)29-21/h1-10,13-14,20H,11-12,25H2
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n/an/a 57n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259288
PNG
(US9499547, 29)
Show SMILES CC(C)(N)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c1-18(2,19)11-23-17-8-7-16-20-10-13(22(16)21-17)15-9-12-5-3-4-6-14(12)24-15/h3-10H,11,19H2,1-2H3
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n/an/a 59n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259302
PNG
(US9499547, 43)
Show SMILES C[C@@H](N)COc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C17H15ClN4O2/c1-10(19)9-23-17-5-4-16-20-8-13(22(16)21-17)15-7-11-6-12(18)2-3-14(11)24-15/h2-8,10H,9,19H2,1H3/t10-/m1/s1
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n/an/a 62n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259303
PNG
(US9499547, 44)
Show SMILES NCC1(COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)COC1
Show InChI InChI=1S/C19H18N4O3/c20-9-19(10-24-11-19)12-25-18-6-5-17-21-8-14(23(17)22-18)16-7-13-3-1-2-4-15(13)26-16/h1-8H,9-12,20H2
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n/an/a 63n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259305
PNG
(US9499547, 46)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H17FN4O2/c23-16-7-4-8-19-15(16)11-20(29-19)18-12-25-21-9-10-22(26-27(18)21)28-13-17(24)14-5-2-1-3-6-14/h1-12,17H,13,24H2/t17-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259304
PNG
(US9499547, 45)
Show SMILES C[C@H](N)COc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1
Show InChI InChI=1S/C17H15FN4O2/c1-10(19)9-23-17-6-5-16-20-8-13(22(16)21-17)15-7-11-12(18)3-2-4-14(11)24-15/h2-8,10H,9,19H2,1H3/t10-/m0/s1
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n/an/a 71n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259307
PNG
(US9499547, 48)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4cccc(F)c4o3)n2n1
Show InChI InChI=1S/C17H15FN4O2/c1-10(8-19)23-16-6-5-15-20-9-13(22(15)21-16)14-7-11-3-2-4-12(18)17(11)24-14/h2-7,9-10H,8,19H2,1H3/t10-/m1/s1
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n/an/a 71n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259310
PNG
(US9499547, 51)
Show SMILES NC1(COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)CC1
Show InChI InChI=1S/C18H16N4O2/c19-18(7-8-18)11-23-17-6-5-16-20-10-13(22(16)21-17)15-9-12-3-1-2-4-14(12)24-15/h1-6,9-10H,7-8,11,19H2
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n/an/a 74n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259289
PNG
(US9499547, 30)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CC1
Show InChI InChI=1S/C19H18N4O2/c20-10-17(12-5-6-12)25-19-8-7-18-21-11-14(23(18)22-19)16-9-13-3-1-2-4-15(13)24-16/h1-4,7-9,11-12,17H,5-6,10,20H2
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n/an/a 75n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259290
PNG
(US9499547, 31)
Show SMILES NCC(CN1CCOCC1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H23N5O3/c22-12-16(14-25-7-9-27-10-8-25)28-21-6-5-20-23-13-17(26(20)24-21)19-11-15-3-1-2-4-18(15)29-19/h1-6,11,13,16H,7-10,12,14,22H2
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n/an/a 78n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259291
PNG
(US9499547, 32)
Show SMILES NC(COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)C1CCOCC1
Show InChI InChI=1S/C21H22N4O3/c22-16(14-7-9-26-10-8-14)13-27-21-6-5-20-23-12-17(25(20)24-21)19-11-15-3-1-2-4-18(15)28-19/h1-6,11-12,14,16H,7-10,13,22H2
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n/an/a 79n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259292
PNG
(US9499547, 33)
Show SMILES CC(C)CC(CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H22N4O2/c1-13(2)9-15(11-21)25-20-8-7-19-22-12-16(24(19)23-20)18-10-14-5-3-4-6-17(14)26-18/h3-8,10,12-13,15H,9,11,21H2,1-2H3
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n/an/a 83n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259308
PNG
(US9499547, 49)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4cc(C)ccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c1-11-3-4-15-13(7-11)8-16(24-15)14-10-20-17-5-6-18(21-22(14)17)23-12(2)9-19/h3-8,10,12H,9,19H2,1-2H3/t12-/m1/s1
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n/an/a 88n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259293
PNG
(US9499547, 34)
Show SMILES NCC(CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H17N5O2/c18-8-12(9-19)23-17-6-5-16-20-10-13(22(16)21-17)15-7-11-3-1-2-4-14(11)24-15/h1-7,10,12H,8-9,18-19H2
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


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More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259316
PNG
(US9499547, 57)
Show SMILES NCC(Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccn1
Show InChI InChI=1S/C21H17N5O2/c22-12-19(15-6-3-4-10-23-15)28-21-9-8-20-24-13-16(26(20)25-21)18-11-14-5-1-2-7-17(14)27-18/h1-11,13,19H,12,22H2
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n/an/a 94n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


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More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259306
PNG
(US9499547, 47)
Show SMILES C[C@@H](CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(9-18)22-17-7-6-16-19-10-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-8,10-11H,9,18H2,1H3/t11-/m0/s1
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n/an/a 95n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259278
PNG
(US9499547, 19)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H17ClN4O2/c23-16-6-7-19-15(10-16)11-20(29-19)18-12-25-21-8-9-22(26-27(18)21)28-13-17(24)14-4-2-1-3-5-14/h1-12,17H,13,24H2/t17-/m1/s1
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n/an/a 111n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259307
PNG
(US9499547, 48)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4cccc(F)c4o3)n2n1
Show InChI InChI=1S/C17H15FN4O2/c1-10(8-19)23-16-6-5-15-20-9-13(22(15)21-16)14-7-11-3-2-4-12(18)17(11)24-14/h2-7,9-10H,8,19H2,1H3/t10-/m1/s1
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n/an/a 115n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259308
PNG
(US9499547, 49)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4cc(C)ccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c1-11-3-4-15-13(7-11)8-16(24-15)14-10-20-17-5-6-18(21-22(14)17)23-12(2)9-19/h3-8,10,12H,9,19H2,1-2H3/t12-/m1/s1
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n/an/a 154n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259274
PNG
(US9499547, 15)
Show SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C17H15ClN4O2/c1-10(8-19)23-17-5-4-16-20-9-13(22(16)21-17)15-7-11-6-12(18)2-3-14(11)24-15/h2-7,9-10H,8,19H2,1H3/t10-/m1/s1
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n/an/a 197n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%