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Patent code US9505734

Compile Data Set for Download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM254941
PNG
(US9505734, I-D1-6)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C21H25ClO5/c1-3-26-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)22)21-20(25)19(24)18(23)12(2)27-21/h4-9,11-12,18-21,23-25H,3,10H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 0.690n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
The IC50 value of the inhibition of the cocrystal of I-D1-6 and L-proline prepared in Example 138 on SGLT2 and SGLT1 is measured according to the met...


US Patent US9505734 (2016)


BindingDB Entry DOI: 10.7270/Q2XW4HQ3
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM254941
PNG
(US9505734, I-D1-6)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)C2OC(C)C(O)C(O)C2O)cc1
Show InChI InChI=1S/C21H25ClO5/c1-3-26-16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)22)21-20(25)19(24)18(23)12(2)27-21/h4-9,11-12,18-21,23-25H,3,10H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 259n/an/an/an/an/an/a



Tianjin Institute of Pharmaceutical Research

US Patent


Assay Description
The IC50 value of the inhibition of the cocrystal of I-D1-6 and L-proline prepared in Example 138 on SGLT2 and SGLT1 is measured according to the met...


US Patent US9505734 (2016)


BindingDB Entry DOI: 10.7270/Q2XW4HQ3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%