BindingDB logo
myBDB logout

Patent code US9505745

Compile Data Set for Download or QSAR
Found 110 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259330
PNG
(US9505745, 7)
Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259342
PNG
(US9505745, 19)
Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259371
PNG
(US9505745, 48)
Show SMILES CCC(c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)=C1CCNCC1
Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259367
PNG
(US9505745, 44 | US9505745, 45)
Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19-,20?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259341
PNG
(US9505745, 18)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O3S/c1-7-28(18-10-8-17(9-11-18)27(4)5)24-16(3)20(14-32-24)22(29)25-13-19-21(31-6)12-15(2)26-23(19)30/h12,14,17-18H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t17-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259359
PNG
(US9505745, 36)
Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H35N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h7,12,14,18-19H,8-11,13H2,1-6H3,(H,26,29)(H,27,30)/b20-7+/t18-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259356
PNG
(US9505745, 33)
Show SMILES C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C22H29N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h5,10,12,16,23H,6-9,11H2,1-4H3,(H,24,26)(H,25,27)/b17-5+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259339
PNG
(US9505745, 16)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C
Show InChI InChI=1S/C26H40N4O2S/c1-7-9-19-14-17(3)28-25(32)22(19)15-27-24(31)23-16-33-26(18(23)4)30(8-2)21-12-10-20(11-13-21)29(5)6/h14,16,20-21H,7-13,15H2,1-6H3,(H,27,31)(H,28,32)/t20-,21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259355
PNG
(US9505745, 32)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259331
PNG
(US9505745, 8)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259335
PNG
(US9505745, 12)
Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259358
PNG
(US9505745, 35)
Show SMILES C\C=C(/[C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H31N3O2S/c1-5-18(16-6-8-17(24)9-7-16)21-15(4)20(12-29-21)22(27)25-11-19-13(2)10-14(3)26-23(19)28/h5,10,12,16-17H,6-9,11,24H2,1-4H3,(H,25,27)(H,26,28)/b18-5+/t16-,17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259341
PNG
(US9505745, 18)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O3S/c1-7-28(18-10-8-17(9-11-18)27(4)5)24-16(3)20(14-32-24)22(29)25-13-19-21(31-6)12-15(2)26-23(19)30/h12,14,17-18H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t17-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259331
PNG
(US9505745, 8)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259369
PNG
(US9505745, 46 | US9505745, 47)
Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19+,20?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259366
PNG
(US9505745, 43)
Show SMILES CCC([C@H]1CC[C@H](N)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H33N3O2S/c1-5-18(16-6-8-17(24)9-7-16)21-15(4)20(12-29-21)22(27)25-11-19-13(2)10-14(3)26-23(19)28/h10,12,16-18H,5-9,11,24H2,1-4H3,(H,25,27)(H,26,28)/t16-,17-,18?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259329
PNG
(US9505745, 6)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259334
PNG
(US9505745, 11)
Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259387
PNG
(US9505745, 64)
Show SMILES CCN(C)[C@H]1CC[C@@H](CC1)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-7-28(6)19-9-11-20(12-10-19)29(8-2)25-18(5)22(15-32-25)23(30)26-14-21-16(3)13-17(4)27-24(21)31/h13,15,19-20H,7-12,14H2,1-6H3,(H,26,30)(H,27,31)/t19-,20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259327
PNG
(US9505745, 4)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259376
PNG
(US9505745, 53)
Show SMILES CCN(C1CCOCC1)c1sc(Cl)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259329
PNG
(US9505745, 6)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)21-15(4)18(12-28-21)19(25)22-11-17-13(2)10-14(3)23-20(17)26/h10,12,16H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259351
PNG
(US9505745, 28)
Show SMILES CCC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259342
PNG
(US9505745, 19)
Show SMILES CCN(C1CCOCC1)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28BrN3O3S/c1-5-25(15-6-8-28-9-7-15)21-14(4)17(18(22)29-21)20(27)23-11-16-12(2)10-13(3)24-19(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259373
PNG
(US9505745, 50)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H35BrN4O2S/c1-7-29(18-10-8-17(9-11-18)28(5)6)24-16(4)20(21(25)32-24)23(31)26-13-19-14(2)12-15(3)27-22(19)30/h12,17-18H,7-11,13H2,1-6H3,(H,26,31)(H,27,30)/t17-,18-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259363
PNG
(US9505745, 40)
Show SMILES CCC(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C22H31N3O2S/c1-5-17(16-6-8-23-9-7-16)20-15(4)19(12-28-20)21(26)24-11-18-13(2)10-14(3)25-22(18)27/h10,12,16-17,23H,5-9,11H2,1-4H3,(H,24,26)(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259364
PNG
(US9505745, 41)
Show SMILES CC[C@H](N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259334
PNG
(US9505745, 11)
Show SMILES CCN(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O4S/c1-8-30(19-9-11-29(12-10-19)25(33)34-26(5,6)7)24-18(4)21(15-35-24)22(31)27-14-20-16(2)13-17(3)28-23(20)32/h13,15,19H,8-12,14H2,1-7H3,(H,27,31)(H,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259367
PNG
(US9505745, 44 | US9505745, 45)
Show SMILES CCC([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19-,20?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259335
PNG
(US9505745, 12)
Show SMILES CCN(C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H30N4O2S/c1-5-25(16-6-8-22-9-7-16)21-15(4)18(12-28-21)19(26)23-11-17-13(2)10-14(3)24-20(17)27/h10,12,16,22H,5-9,11H2,1-4H3,(H,23,26)(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259390
PNG
(US9505745, 67)
Show SMILES CCN(C1CCNCC1F)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29FN4O2S/c1-5-26(18-6-7-23-10-17(18)22)21-14(4)16(11-29-21)19(27)24-9-15-12(2)8-13(3)25-20(15)28/h8,11,17-18,23H,5-7,9-10H2,1-4H3,(H,24,27)(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259330
PNG
(US9505745, 7)
Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)24-17(4)21(14-31-24)22(29)25-13-20-15(2)12-16(3)26-23(20)30/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t18-,19+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259398
PNG
(US9505745, 75)
Show SMILES CCN(C1CCOCC1)c1sc(-c2ccoc2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H31N3O4S/c1-5-28(19-7-10-31-11-8-19)25-17(4)21(22(33-25)18-6-9-32-14-18)24(30)26-13-20-15(2)12-16(3)27-23(20)29/h6,9,12,14,19H,5,7-8,10-11,13H2,1-4H3,(H,26,30)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259327
PNG
(US9505745, 4)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259374
PNG
(US9505745, 51)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(C#N)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H35N5O2S/c1-7-30(19-10-8-18(9-11-19)29(5)6)25-17(4)22(21(13-26)33-25)24(32)27-14-20-15(2)12-16(3)28-23(20)31/h12,18-19H,7-11,14H2,1-6H3,(H,27,32)(H,28,31)/t18-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259339
PNG
(US9505745, 16)
Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1csc(N(CC)[C@H]2CC[C@@H](CC2)N(C)C)c1C
Show InChI InChI=1S/C26H40N4O2S/c1-7-9-19-14-17(3)28-25(32)22(19)15-27-24(31)23-16-33-26(18(23)4)30(8-2)21-12-10-20(11-13-21)29(5)6/h14,16,20-21H,7-13,15H2,1-6H3,(H,27,31)(H,28,32)/t20-,21-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259350
PNG
(US9505745, 27)
Show SMILES CC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H34N4O2S/c1-14-11-15(2)25-23(29)19(14)12-24-22(28)20-13-30-21(16(20)3)17(4)27-9-7-18(8-10-27)26(5)6/h11,13,17-18H,7-10,12H2,1-6H3,(H,24,28)(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259328
PNG
(US9505745, 5)
Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259400
PNG
(US9505745, 77)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1sc(-c2ccoc2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C28H38N4O3S/c1-7-32(22-10-8-21(9-11-22)31(5)6)28-19(4)24(25(36-28)20-12-13-35-16-20)27(34)29-15-23-17(2)14-18(3)30-26(23)33/h12-14,16,21-22H,7-11,15H2,1-6H3,(H,29,34)(H,30,33)/t21-,22-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259377
PNG
(US9505745, 54)
Show SMILES CCN(C1CCOCC1)c1sc(C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-15(4)19(16(5)29-22)21(27)23-12-18-13(2)11-14(3)24-20(18)26/h11,17H,6-10,12H2,1-5H3,(H,23,27)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259399
PNG
(US9505745, 76)
Show SMILES CCN(C1CCOCC1)c1sc(-c2ccco2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H31N3O4S/c1-5-28(18-8-11-31-12-9-18)25-17(4)21(22(33-25)20-7-6-10-32-20)24(30)26-14-19-15(2)13-16(3)27-23(19)29/h6-7,10,13,18H,5,8-9,11-12,14H2,1-4H3,(H,26,30)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259362
PNG
(US9505745, 39)
Show SMILES CCC(C1CCN(CC1)C(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C27H39N3O4S/c1-8-20(19-9-11-30(12-10-19)26(33)34-27(5,6)7)23-18(4)22(15-35-23)24(31)28-14-21-16(2)13-17(3)29-25(21)32/h13,15,19-20H,8-12,14H2,1-7H3,(H,28,31)(H,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259328
PNG
(US9505745, 5)
Show SMILES CCN([C@@H]1CC[C@@H](CC1)N(C)C)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-10-8-18(9-11-19)27(5)6)21-14-31-22(17(21)4)24(30)25-13-20-15(2)12-16(3)26-23(20)29/h12,14,18-19H,7-11,13H2,1-6H3,(H,25,30)(H,26,29)/t18-,19+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259355
PNG
(US9505745, 32)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-8-29(20-11-9-19(10-12-20)27(5)6)25-18(4)22(15-32-25)23(30)26-14-21-16(2)13-17(3)28(7)24(21)31/h13,15,19-20H,8-12,14H2,1-7H3,(H,26,30)/t19-,20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259389
PNG
(US9505745, 66)
Show SMILES CCN(C1CCN(CC1)C(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-28(19-8-10-27(11-9-19)15(2)3)24-18(6)21(14-31-24)22(29)25-13-20-16(4)12-17(5)26-23(20)30/h12,14-15,19H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259350
PNG
(US9505745, 27)
Show SMILES CC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H34N4O2S/c1-14-11-15(2)25-23(29)19(14)12-24-22(28)20-13-30-21(16(20)3)17(4)27-9-7-18(8-10-27)26(5)6/h11,13,17-18H,7-10,12H2,1-6H3,(H,24,28)(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259325
PNG
(US9505745, 2)
Show SMILES CCN(C1CCOCC1)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)18-12-28-19(15(18)4)21(26)22-11-17-13(2)10-14(3)23-20(17)25/h10,12,16H,5-9,11H2,1-4H3,(H,22,26)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259351
PNG
(US9505745, 28)
Show SMILES CCC(N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259338
PNG
(US9505745, 15)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C21H26F3N3O3S/c1-4-27(14-5-7-30-8-6-14)20-13(3)16(11-31-20)18(28)25-10-15-17(21(22,23)24)9-12(2)26-19(15)29/h9,11,14H,4-8,10H2,1-3H3,(H,25,28)(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259378
PNG
(US9505745, 55)
Show SMILES CCN(C1CCOCC1)c1sc(C#N)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C22H28N4O3S/c1-5-26(16-6-8-29-9-7-16)22-15(4)19(18(11-23)30-22)21(28)24-12-17-13(2)10-14(3)25-20(17)27/h10,16H,5-9,12H2,1-4H3,(H,24,28)(H,25,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259391
PNG
(US9505745, 68)
Show SMILES Cc1c(csc1N1CCCC1C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H32N4O2S/c1-14-11-15(2)26-22(29)18(14)12-25-21(28)19-13-30-23(16(19)3)27-10-4-5-20(27)17-6-8-24-9-7-17/h11,13,17,20,24H,4-10,12H2,1-3H3,(H,25,28)(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259357
PNG
(US9505745, 34)
Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)NC(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C28H39N3O4S/c1-8-21(19-9-11-20(12-10-19)31-27(34)35-28(5,6)7)24-18(4)23(15-36-24)25(32)29-14-22-16(2)13-17(3)30-26(22)33/h8,13,15,19-20H,9-12,14H2,1-7H3,(H,29,32)(H,30,33)(H,31,34)/b21-8+/t19-,20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259393
PNG
(US9505745, 70)
Show SMILES Cc1c(csc1-c1cccc2CNCCc12)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H25N3O2S/c1-13-9-14(2)26-23(28)19(13)11-25-22(27)20-12-29-21(15(20)3)18-6-4-5-16-10-24-8-7-17(16)18/h4-6,9,12,24H,7-8,10-11H2,1-3H3,(H,25,27)(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259401
PNG
(US9505745, 78)
Show SMILES CCN(C1CCOCC1)c1sc(-c2cnn(C)c2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H33N5O3S/c1-6-30(19-7-9-33-10-8-19)25-17(4)21(22(34-25)18-12-27-29(5)14-18)24(32)26-13-20-15(2)11-16(3)28-23(20)31/h11-12,14,19H,6-10,13H2,1-5H3,(H,26,32)(H,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259354
PNG
(US9505745, 31)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259344
PNG
(US9505745, 21)
Show SMILES Cc1c(csc1C(O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H27N3O3S/c1-11-8-12(2)23-20(26)15(11)9-22-19(25)16-10-27-18(13(16)3)17(24)14-4-6-21-7-5-14/h8,10,14,17,21,24H,4-7,9H2,1-3H3,(H,22,25)(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259326
PNG
(US9505745, 3)
Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259348
PNG
(US9505745, 25)
Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C19H25N3O2S/c1-11-8-12(2)21-18(24)15(11)9-20-17(23)16-10-25-19(14(16)4)22-7-5-6-13(22)3/h8,10,13H,5-7,9H2,1-4H3,(H,20,23)(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259396
PNG
(US9505745, 73)
Show SMILES CCC(CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H38N4O2S/c1-6-20(8-7-9-29-12-10-28(5)11-13-29)23-19(4)22(16-32-23)24(30)26-15-21-17(2)14-18(3)27-25(21)31/h14,16,20H,6-13,15H2,1-5H3,(H,26,30)(H,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259372
PNG
(US9505745, 49)
Show SMILES Cc1c(csc1C(=C)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H27N3O2S/c1-12-9-13(2)24-21(26)17(12)10-23-20(25)18-11-27-19(15(18)4)14(3)16-5-7-22-8-6-16/h9,11,16,22H,3,5-8,10H2,1-2,4H3,(H,23,25)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259343
PNG
(US9505745, 20)
Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C
Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259361
PNG
(US9505745, 38)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)C(O)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H33N3O3S/c1-13-10-14(2)25-23(29)18(13)11-24-22(28)19-12-30-21(15(19)3)20(27)16-6-8-17(9-7-16)26(4)5/h10,12,16-17,20,27H,6-9,11H2,1-5H3,(H,24,28)(H,25,29)/t16-,17-,20?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259397
PNG
(US9505745, 74)
Show SMILES C\C=C(/CCCN1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C27H40N4O2S/c1-7-21(9-8-12-31-13-10-22(11-14-31)30(5)6)25-20(4)24(17-34-25)26(32)28-16-23-18(2)15-19(3)29-27(23)33/h7,15,17,22H,8-14,16H2,1-6H3,(H,28,32)(H,29,33)/b21-7+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259326
PNG
(US9505745, 3)
Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259388
PNG
(US9505745, 65)
Show SMILES CCOC(=O)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C19H25N3O4S/c1-6-22(19(25)26-7-2)18-13(5)15(10-27-18)16(23)20-9-14-11(3)8-12(4)21-17(14)24/h8,10H,6-7,9H2,1-5H3,(H,20,23)(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259325
PNG
(US9505745, 2)
Show SMILES CCN(C1CCOCC1)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)18-12-28-19(15(18)4)21(26)22-11-17-13(2)10-14(3)23-20(17)25/h10,12,16H,5-9,11H2,1-4H3,(H,22,26)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259380
PNG
(US9505745, 57)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C30H44N4O5S/c1-8-34(22-10-13-38-14-11-22)28-20(4)24(27(36)31-16-23-18(2)15-19(3)32-26(23)35)25(40-28)21-9-12-33(17-21)29(37)39-30(5,6)7/h15,21-22H,8-14,16-17H2,1-7H3,(H,31,36)(H,32,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259347
PNG
(US9505745, 24)
Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O4S/c1-13-9-14(2)25-21(28)17(13)10-24-20(27)18-12-31-19(15(18)3)16-7-8-26(11-16)22(29)30-23(4,5)6/h9,12,16H,7-8,10-11H2,1-6H3,(H,24,27)(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259395
PNG
(US9505745, 72)
Show SMILES C\C=C(/CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H36N4O2S/c1-6-20(8-7-9-29-12-10-28(5)11-13-29)23-19(4)22(16-32-23)24(30)26-15-21-17(2)14-18(3)27-25(21)31/h6,14,16H,7-13,15H2,1-5H3,(H,26,30)(H,27,31)/b20-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 251n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259365
PNG
(US9505745, 42)
Show SMILES CC[C@@H](N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C24H36N4O2S/c1-7-21(28-10-8-18(9-11-28)27(5)6)22-17(4)20(14-31-22)23(29)25-13-19-15(2)12-16(3)26-24(19)30/h12,14,18,21H,7-11,13H2,1-6H3,(H,25,29)(H,26,30)/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259382
PNG
(US9505745, 59)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C31H46N4O5S/c1-8-35(23-11-15-39-16-12-23)29-21(4)25(28(37)32-18-24-19(2)17-20(3)33-27(24)36)26(41-29)22-9-13-34(14-10-22)30(38)40-31(5,6)7/h17,22-23H,8-16,18H2,1-7H3,(H,32,37)(H,33,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259340
PNG
(US9505745, 17)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C24H33F3N4O2S/c1-6-31(17-9-7-16(8-10-17)30(4)5)23-15(3)19(13-34-23)21(32)28-12-18-14(2)11-20(24(25,26)27)29-22(18)33/h11,13,16-17H,6-10,12H2,1-5H3,(H,28,32)(H,29,33)/t16-,17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259344
PNG
(US9505745, 21)
Show SMILES Cc1c(csc1C(O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H27N3O3S/c1-11-8-12(2)23-20(26)15(11)9-22-19(25)16-10-27-18(13(16)3)17(24)14-4-6-21-7-5-14/h8,10,14,17,21,24H,4-7,9H2,1-3H3,(H,22,25)(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259375
PNG
(US9505745, 52)
Show SMILES CCN(CC)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C18H24BrN3O2S/c1-6-22(7-2)18-12(5)14(15(19)25-18)17(24)20-9-13-10(3)8-11(4)21-16(13)23/h8H,6-7,9H2,1-5H3,(H,20,24)(H,21,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259369
PNG
(US9505745, 46 | US9505745, 47)
Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H37N3O2S/c1-7-20(18-8-10-19(11-9-18)28(5)6)23-17(4)22(14-31-23)24(29)26-13-21-15(2)12-16(3)27-25(21)30/h12,14,18-20H,7-11,13H2,1-6H3,(H,26,29)(H,27,30)/t18-,19+,20?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259336
PNG
(US9505745, 13)
Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H32N4O2S/c1-14-10-15(2)24-22(28)19(14)12-23-21(27)17-11-20(29-13-17)16(3)26-8-6-18(7-9-26)25(4)5/h10-11,13,16,18H,6-9,12H2,1-5H3,(H,23,27)(H,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259352
PNG
(US9505745, 29)
Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-18(24-6-8-27-9-7-24)19-15(4)17(12-28-19)20(25)22-11-16-13(2)10-14(3)23-21(16)26/h10,12,18H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 398n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259345
PNG
(US9505745, 22)
Show SMILES Cc1c(csc1C1CCCN1C1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O3S/c1-14-11-15(2)25-23(28)18(14)12-24-22(27)19-13-30-21(16(19)3)20-5-4-8-26(20)17-6-9-29-10-7-17/h11,13,17,20H,4-10,12H2,1-3H3,(H,24,27)(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 398n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259392
PNG
(US9505745, 69)
Show SMILES Cc1c(csc1N1CCCCC1C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C24H34N4O2S/c1-15-12-16(2)27-23(30)19(15)13-26-22(29)20-14-31-24(17(20)3)28-11-5-4-6-21(28)18-7-9-25-10-8-18/h12,14,18,21,25H,4-11,13H2,1-3H3,(H,26,29)(H,27,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259346
PNG
(US9505745, 23)
Show SMILES Cc1c(csc1-c1cnn(c1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H27N5O2S/c1-13-8-14(2)26-22(29)18(13)10-24-21(28)19-12-30-20(15(19)3)16-9-25-27(11-16)17-4-6-23-7-5-17/h8-9,11-12,17,23H,4-7,10H2,1-3H3,(H,24,28)(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259384
PNG
(US9505745, 61)
Show SMILES CCN(C1CCOCC1)c1sc(c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CCN(C)CC1
Show InChI InChI=1S/C27H38N4O3S/c1-6-31(21-9-13-34-14-10-21)27-19(4)23(24(35-27)20-7-11-30(5)12-8-20)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h7,15,21H,6,8-14,16H2,1-5H3,(H,28,33)(H,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259360
PNG
(US9505745, 37)
Show SMILES Cc1c(csc1C(O)[C@H]1CC[C@H](N)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H29N3O3S/c1-11-8-12(2)24-21(27)16(11)9-23-20(26)17-10-28-19(13(17)3)18(25)14-4-6-15(22)7-5-14/h8,10,14-15,18,25H,4-7,9,22H2,1-3H3,(H,23,26)(H,24,27)/t14-,15-,18?
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259386
PNG
(US9505745, 63)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C27H40N4O5S2/c1-6-31(21-9-13-36-14-10-21)27-19(4)23(24(37-27)20-7-11-30(12-8-20)38(5,34)35)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h15,20-21H,6-14,16H2,1-5H3,(H,28,33)(H,29,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259379
PNG
(US9505745, 56)
Show SMILES CCN(C1CCOCC1)c1sc(N2CCN(C)CC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H39N5O3S/c1-6-31(20-7-13-34-14-8-20)25-19(4)22(26(35-25)30-11-9-29(5)10-12-30)24(33)27-16-21-17(2)15-18(3)28-23(21)32/h15,20H,6-14,16H2,1-5H3,(H,27,33)(H,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259385
PNG
(US9505745, 62)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O5S2/c1-6-30(20-8-11-35-12-9-20)26-18(4)22(23(36-26)19-7-10-29(15-19)37(5,33)34)25(32)27-14-21-16(2)13-17(3)28-24(21)31/h13,19-20H,6-12,14-15H2,1-5H3,(H,27,32)(H,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259338
PNG
(US9505745, 15)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C21H26F3N3O3S/c1-4-27(14-5-7-30-8-6-14)20-13(3)16(11-31-20)18(28)25-10-15-17(21(22,23)24)9-12(2)26-19(15)29/h9,11,14H,4-8,10H2,1-3H3,(H,25,28)(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259340
PNG
(US9505745, 17)
Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C
Show InChI InChI=1S/C24H33F3N4O2S/c1-6-31(17-9-7-16(8-10-17)30(4)5)23-15(3)19(13-34-23)21(32)28-12-18-14(2)11-20(24(25,26)27)29-22(18)33/h11,13,16-17H,6-10,12H2,1-5H3,(H,28,32)(H,29,33)/t16-,17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259349
PNG
(US9505745, 26)
Show SMILES CC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C20H27N3O3S/c1-12-9-13(2)22-20(25)16(12)10-21-19(24)17-11-27-18(14(17)3)15(4)23-5-7-26-8-6-23/h9,11,15H,5-8,10H2,1-4H3,(H,21,24)(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259348
PNG
(US9505745, 25)
Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C19H25N3O2S/c1-11-8-12(2)21-18(24)15(11)9-20-17(23)16-10-25-19(14(16)4)22-7-5-6-13(22)3/h8,10,13H,5-7,9H2,1-4H3,(H,20,23)(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259337
PNG
(US9505745, 14)
Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259383
PNG
(US9505745, 60)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCNCC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C26H38N4O3S/c1-5-30(20-8-12-33-13-9-20)26-18(4)22(23(34-26)19-6-10-27-11-7-19)25(32)28-15-21-16(2)14-17(3)29-24(21)31/h14,19-20,27H,5-13,15H2,1-4H3,(H,28,32)(H,29,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 631n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259381
PNG
(US9505745, 58)
Show SMILES CCN(C1CCOCC1)c1sc(C2CCNC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C25H36N4O3S/c1-5-29(19-7-10-32-11-8-19)25-17(4)21(22(33-25)18-6-9-26-13-18)24(31)27-14-20-15(2)12-16(3)28-23(20)30/h12,18-19,26H,5-11,13-14H2,1-4H3,(H,27,31)(H,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259354
PNG
(US9505745, 31)
Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C
Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259394
PNG
(US9505745, 71)
Show SMILES C\C=C(/CCN1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C23H31N3O3S/c1-5-18(6-7-26-8-10-29-11-9-26)21-17(4)20(14-30-21)22(27)24-13-19-15(2)12-16(3)25-23(19)28/h5,12,14H,6-11,13H2,1-4H3,(H,24,27)(H,25,28)/b18-5+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259343
PNG
(US9505745, 20)
Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C
Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.59E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259336
PNG
(US9505745, 13)
Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H32N4O2S/c1-14-10-15(2)24-22(28)19(14)12-23-21(27)17-11-20(29-13-17)16(3)26-8-6-18(7-9-26)25(4)5/h10-11,13,16,18H,6-9,12H2,1-5H3,(H,23,27)(H,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259337
PNG
(US9505745, 14)
Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259324
PNG
(US9505745, 1)
Show SMILES CC(C)Oc1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C17H22N2O3S/c1-9(2)22-14-8-23-15(12(14)5)17(21)18-7-13-10(3)6-11(4)19-16(13)20/h6,8-9H,7H2,1-5H3,(H,18,21)(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.16E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259352
PNG
(US9505745, 29)
Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C21H29N3O3S/c1-5-18(24-6-8-27-9-7-24)19-15(4)17(12-28-19)20(25)22-11-16-13(2)10-14(3)23-21(16)26/h10,12,18H,5-9,11H2,1-4H3,(H,22,25)(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.16E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259347
PNG
(US9505745, 24)
Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O4S/c1-13-9-14(2)25-21(28)17(13)10-24-20(27)18-12-31-19(15(18)3)16-7-8-26(11-16)22(29)30-23(4,5)6/h9,12,16H,7-8,10-11H2,1-6H3,(H,24,27)(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.98E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259346
PNG
(US9505745, 23)
Show SMILES Cc1c(csc1-c1cnn(c1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C22H27N5O2S/c1-13-8-14(2)26-22(29)18(13)10-24-21(28)19-12-30-20(15(19)3)16-9-25-27(11-16)17-4-6-23-7-5-17/h8-9,11-12,17,23H,4-7,10H2,1-3H3,(H,24,28)(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.98E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259349
PNG
(US9505745, 26)
Show SMILES CC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C20H27N3O3S/c1-12-9-13(2)22-20(25)16(12)10-21-19(24)17-11-27-18(14(17)3)15(4)23-5-7-26-8-6-23/h9,11,15H,5-8,10H2,1-4H3,(H,21,24)(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.01E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259345
PNG
(US9505745, 22)
Show SMILES Cc1c(csc1C1CCCN1C1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C23H31N3O3S/c1-14-11-15(2)25-23(28)18(14)12-24-22(27)19-13-30-21(16(19)3)20-5-4-8-26(20)17-6-9-29-10-7-17/h11,13,17,20H,4-10,12H2,1-3H3,(H,24,27)(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31E+3n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259333
PNG
(US9505745, 10)
Show SMILES Cc1c(cnn1CC1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H26N4O3/c1-12-8-13(2)22-19(25)16(12)9-20-18(24)17-10-21-23(14(17)3)11-15-4-6-26-7-5-15/h8,10,15H,4-7,9,11H2,1-3H3,(H,20,24)(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259332
PNG
(US9505745, 9)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H20N4O2/c1-12-9-13(2)22-19(25)16(12)10-20-18(24)17-11-21-23(14(17)3)15-7-5-4-6-8-15/h4-9,11H,10H2,1-3H3,(H,20,24)(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259324
PNG
(US9505745, 1)
Show SMILES CC(C)Oc1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
Show InChI InChI=1S/C17H22N2O3S/c1-9(2)22-14-8-23-15(12(14)5)17(21)18-7-13-10(3)6-11(4)19-16(13)20/h6,8-9H,7H2,1-5H3,(H,18,21)(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.51E+4n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259353
PNG
(US9505745, 30)
Show SMILES CCN(C1CCOCC1)c1ccc(s1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H27N3O3S/c1-4-23(15-7-9-26-10-8-15)18-6-5-17(27-18)20(25)21-12-16-13(2)11-14(3)22-19(16)24/h5-6,11,15H,4,7-10,12H2,1-3H3,(H,21,25)(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.98E+4n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259332
PNG
(US9505745, 9)
Show SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H20N4O2/c1-12-9-13(2)22-19(25)16(12)10-20-18(24)17-11-21-23(14(17)3)15-7-5-4-6-8-15/h4-9,11H,10H2,1-3H3,(H,20,24)(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.31E+4n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259333
PNG
(US9505745, 10)
Show SMILES Cc1c(cnn1CC1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C19H26N4O3/c1-12-8-13(2)22-19(25)16(12)9-20-18(24)17-10-21-23(14(17)3)11-15-4-6-26-7-5-15/h8,10,15H,4-7,9,11H2,1-3H3,(H,20,24)(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
Polycomb Repressor Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM259353
PNG
(US9505745, 30)
Show SMILES CCN(C1CCOCC1)c1ccc(s1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Show InChI InChI=1S/C20H27N3O3S/c1-4-23(15-7-9-26-10-8-15)18-6-5-17(27-18)20(25)21-12-16-13(2)11-14(3)22-19(16)24/h5-6,11,15H,4,7-10,12H2,1-3H3,(H,21,25)(H,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property (No. 2) Limited

US Patent


Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%