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Patent code US9505765

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254948
PNG
(US9505765, 38)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(N)=O)c12
Show InChI InChI=1S/C13H16N4O2/c1-8(2)6-19-13-11-9(3-4-10(14)18)5-15-12(11)16-7-17-13/h3-5,7-8H,6H2,1-2H3,(H2,14,18)(H,15,16,17)/b4-3+
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.10n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254963
PNG
(US9505765, 187)
Show SMILES CCC(C)Oc1ncnc2[nH]cc(\C=C\C(N)=O)c12
Show InChI InChI=1S/C13H16N4O2/c1-3-8(2)19-13-11-9(4-5-10(14)18)6-15-12(11)16-7-17-13/h4-8H,3H2,1-2H3,(H2,14,18)(H,15,16,17)/b5-4+
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254964
PNG
(US9505765, 188)
Show SMILES CC(C)Oc1ncnc2[nH]cc(\C=C\C(N)=O)c12
Show InChI InChI=1S/C12H14N4O2/c1-7(2)18-12-10-8(3-4-9(13)17)5-14-11(10)15-6-16-12/h3-7H,1-2H3,(H2,13,17)(H,14,15,16)/b4-3+
PDB

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n/an/a 4.40n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254968
PNG
(US9505765, 192)
Show SMILES CC(C)(C)COc1ncnc2[nH]cc(\C=C\C(N)=O)c12
Show InChI InChI=1S/C14H18N4O2/c1-14(2,3)7-20-13-11-9(4-5-10(15)19)6-16-12(11)17-8-18-13/h4-6,8H,7H2,1-3H3,(H2,15,19)(H,16,17,18)/b5-4+
PDB

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US Patent
n/an/a 5.20n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254962
PNG
(US9505765, 186)
Show SMILES CC(C)COc1ncnc2[nH]cc(C#CC(N)=O)c12
Show InChI InChI=1S/C13H14N4O2/c1-8(2)6-19-13-11-9(3-4-10(14)18)5-15-12(11)16-7-17-13/h5,7-8H,6H2,1-2H3,(H2,14,18)(H,15,16,17)
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254971
PNG
(US9505765, 195)
Show SMILES CC(C)(C)Oc1ncnc2[nH]cc(\C=C\C(N)=O)c12
Show InChI InChI=1S/C13H16N4O2/c1-13(2,3)19-12-10-8(4-5-9(14)18)6-15-11(10)16-7-17-12/h4-7H,1-3H3,(H2,14,18)(H,15,16,17)/b5-4+
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n/an/a 13n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254975
PNG
(US9505765, 199)
Show SMILES NC(=O)\C=C\c1c[nH]c2ncnc(OC3CCC(F)(F)CC3)c12
Show InChI InChI=1S/C15H16F2N4O2/c16-15(17)5-3-10(4-6-15)23-14-12-9(1-2-11(18)22)7-19-13(12)20-8-21-14/h1-2,7-8,10H,3-6H2,(H2,18,22)(H,19,20,21)/b2-1+
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n/an/a 16n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254965
PNG
(US9505765, 189)
Show SMILES CCCOc1ncnc2[nH]cc(\C=C\C(N)=O)c12
Show InChI InChI=1S/C12H14N4O2/c1-2-5-18-12-10-8(3-4-9(13)17)6-14-11(10)15-7-16-12/h3-4,6-7H,2,5H2,1H3,(H2,13,17)(H,14,15,16)/b4-3+
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n/an/a 19n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254967
PNG
(US9505765, 191)
Show SMILES NC(=O)\C=C\c1c[nH]c2ncnc(OCC(F)(F)F)c12
Show InChI InChI=1S/C11H9F3N4O2/c12-11(13,14)4-20-10-8-6(1-2-7(15)19)3-16-9(8)17-5-18-10/h1-3,5H,4H2,(H2,15,19)(H,16,17,18)/b2-1+
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UniChem
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n/an/a 33n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254949
PNG
(US9505765, 39)
Show SMILES CNC(=O)\C=C\c1c[nH]c2ncnc(OCC(C)C)c12
Show InChI InChI=1S/C14H18N4O2/c1-9(2)7-20-14-12-10(4-5-11(19)15-3)6-16-13(12)17-8-18-14/h4-6,8-9H,7H2,1-3H3,(H,15,19)(H,16,17,18)/b5-4+
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254970
PNG
(US9505765, 194)
Show SMILES NC(=O)\C=C\c1c[nH]c2ncnc(OCc3cccc(F)c3)c12
Show InChI InChI=1S/C16H13FN4O2/c17-12-3-1-2-10(6-12)8-23-16-14-11(4-5-13(18)22)7-19-15(14)20-9-21-16/h1-7,9H,8H2,(H2,18,22)(H,19,20,21)/b5-4+
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n/an/a 51n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254969
PNG
(US9505765, 193)
Show SMILES CC(C)(O)COc1ncnc2[nH]cc(\C=C\C(N)=O)c12
Show InChI InChI=1S/C13H16N4O3/c1-13(2,19)6-20-12-10-8(3-4-9(14)18)5-15-11(10)16-7-17-12/h3-5,7,19H,6H2,1-2H3,(H2,14,18)(H,15,16,17)/b4-3+
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UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254961
PNG
(US9505765, 184)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(=O)N(C)C)c12
Show InChI InChI=1S/C15H20N4O2/c1-10(2)8-21-15-13-11(5-6-12(20)19(3)4)7-16-14(13)17-9-18-15/h5-7,9-10H,8H2,1-4H3,(H,16,17,18)/b6-5+
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254947
PNG
(US9505765, 37)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(C)=O)c12
Show InChI InChI=1S/C14H17N3O2/c1-9(2)7-19-14-12-11(5-4-10(3)18)6-15-13(12)16-8-17-14/h4-6,8-9H,7H2,1-3H3,(H,15,16,17)/b5-4+
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254946
PNG
(US9505765, 36)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C/C#N)c12
Show InChI InChI=1S/C13H14N4O/c1-9(2)7-18-13-11-10(4-3-5-14)6-15-12(11)16-8-17-13/h3-4,6,8-9H,7H2,1-2H3,(H,15,16,17)/b4-3-
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254966
PNG
(US9505765, 190)
Show SMILES NC(=O)\C=C\c1c[nH]c2ncnc(Oc3ccccc3)c12
Show InChI InChI=1S/C15H12N4O2/c16-12(20)7-6-10-8-17-14-13(10)15(19-9-18-14)21-11-4-2-1-3-5-11/h1-9H,(H2,16,20)(H,17,18,19)/b7-6+
PDB

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UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254958
PNG
(US9505765, 181)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(=O)NC3CC3)c12
Show InChI InChI=1S/C16H20N4O2/c1-10(2)8-22-16-14-11(7-17-15(14)18-9-19-16)3-6-13(21)20-12-4-5-12/h3,6-7,9-10,12H,4-5,8H2,1-2H3,(H,20,21)(H,17,18,19)/b6-3+
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UniChem
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n/an/a 180n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254953
PNG
(US9505765, 176)
Show SMILES COC(=O)\C=C\c1c[nH]c2ncnc(OCC(C)C)c12
Show InChI InChI=1S/C14H17N3O3/c1-9(2)7-20-14-12-10(4-5-11(18)19-3)6-15-13(12)16-8-17-14/h4-6,8-9H,7H2,1-3H3,(H,15,16,17)/b5-4+
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PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254952
PNG
(US9505765, 175)
Show SMILES CCC(=O)\C=C\c1c[nH]c2ncnc(OCC(C)C)c12
Show InChI InChI=1S/C15H19N3O2/c1-4-12(19)6-5-11-7-16-14-13(11)15(18-9-17-14)20-8-10(2)3/h5-7,9-10H,4,8H2,1-3H3,(H,16,17,18)/b6-5+
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UniChem
US Patent
n/an/a 200n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254945
PNG
(US9505765, 35)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C#N)c12
Show InChI InChI=1S/C13H14N4O/c1-9(2)7-18-13-11-10(4-3-5-14)6-15-12(11)16-8-17-13/h3-4,6,8-9H,7H2,1-2H3,(H,15,16,17)/b4-3+
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254944
PNG
(US9505765, 23)
Show SMILES CC(C)COc1ncnc2[nH]cc(C(=O)CCl)c12
Show InChI InChI=1S/C12H14ClN3O2/c1-7(2)5-18-12-10-8(9(17)3-13)4-14-11(10)15-6-16-12/h4,6-7H,3,5H2,1-2H3,(H,14,15,16)
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254950
PNG
(US9505765, 93)
Show SMILES N#C\C=C\c1c[nH]c2ncnc(OCc3ccccc3)c12
Show InChI InChI=1S/C16H12N4O/c17-8-4-7-13-9-18-15-14(13)16(20-11-19-15)21-10-12-5-2-1-3-6-12/h1-7,9,11H,10H2,(H,18,19,20)/b7-4+
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CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254956
PNG
(US9505765, 179)
Show SMILES CCNC(=O)\C=C\c1c[nH]c2ncnc(OCC(C)C)c12
Show InChI InChI=1S/C15H20N4O2/c1-4-16-12(20)6-5-11-7-17-14-13(11)15(19-9-18-14)21-8-10(2)3/h5-7,9-10H,4,8H2,1-3H3,(H,16,20)(H,17,18,19)/b6-5+
PDB

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PC sid
UniChem
US Patent
n/an/a 340n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254955
PNG
(US9505765, 178)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(O)=O)c12
Show InChI InChI=1S/C13H15N3O3/c1-8(2)6-19-13-11-9(3-4-10(17)18)5-14-12(11)15-7-16-13/h3-5,7-8H,6H2,1-2H3,(H,17,18)(H,14,15,16)/b4-3+
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 340n/an/an/an/an/an/a



CONFLUENCE LIFE SCIENCES INC.

US Patent


Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254977
PNG
(US9505765, 201)
Show SMILES COC(=O)\C=C\c1c[nH]c2ncnc(OCc3ccccc3)c12
Show InChI InChI=1S/C17H15N3O3/c1-22-14(21)8-7-13-9-18-16-15(13)17(20-11-19-16)23-10-12-5-3-2-4-6-12/h2-9,11H,10H2,1H3,(H,18,19,20)/b8-7+
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


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More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254972
PNG
(US9505765, 196)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C(/Cl)C(N)=O)c12
Show InChI InChI=1S/C13H15ClN4O2/c1-7(2)5-20-13-10-8(3-9(14)11(15)19)4-16-12(10)17-6-18-13/h3-4,6-7H,5H2,1-2H3,(H2,15,19)(H,16,17,18)/b9-3-
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254957
PNG
(US9505765, 180)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(=O)NCC3CC3)c12
Show InChI InChI=1S/C17H22N4O2/c1-11(2)9-23-17-15-13(8-19-16(15)20-10-21-17)5-6-14(22)18-7-12-3-4-12/h5-6,8,10-12H,3-4,7,9H2,1-2H3,(H,18,22)(H,19,20,21)/b6-5+
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254974
PNG
(US9505765, 198)
Show SMILES CC(C)COc1ncnc2[nH]cc(C\C=C\C(N)=O)c12
Show InChI InChI=1S/C14H18N4O2/c1-9(2)7-20-14-12-10(4-3-5-11(15)19)6-16-13(12)17-8-18-14/h3,5-6,8-9H,4,7H2,1-2H3,(H2,15,19)(H,16,17,18)/b5-3+
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254954
PNG
(US9505765, 177)
Show SMILES COC(=O)C(\C)=C\c1c[nH]c2ncnc(OCC(C)C)c12
Show InChI InChI=1S/C15H19N3O3/c1-9(2)7-21-14-12-11(5-10(3)15(19)20-4)6-16-13(12)17-8-18-14/h5-6,8-9H,7H2,1-4H3,(H,16,17,18)/b10-5+
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254942
PNG
(US9505765, 1)
Show SMILES CC(C)COc1ncnc2[nH]cc(C#N)c12
Show InChI InChI=1S/C11H12N4O/c1-7(2)5-16-11-9-8(3-12)4-13-10(9)14-6-15-11/h4,6-7H,5H2,1-2H3,(H,13,14,15)
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254951
PNG
(US9505765, 96)
Show SMILES NC(=O)\C=C\c1c[nH]c2ncnc(OCc3ccccc3)c12
Show InChI InChI=1S/C16H14N4O2/c17-13(21)7-6-12-8-18-15-14(12)16(20-10-19-15)22-9-11-4-2-1-3-5-11/h1-8,10H,9H2,(H2,17,21)(H,18,19,20)/b7-6+
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254973
PNG
(US9505765, 197)
Show SMILES CC(C)COc1ncnc2[nH]cc(C(=C)C#N)c12
Show InChI InChI=1S/C13H14N4O/c1-8(2)6-18-13-11-10(9(3)4-14)5-15-12(11)16-7-17-13/h5,7-8H,3,6H2,1-2H3,(H,15,16,17)
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254976
PNG
(US9505765, 200)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C(/F)C(N)=O)c12
Show InChI InChI=1S/C13H15FN4O2/c1-7(2)5-20-13-10-8(3-9(14)11(15)19)4-16-12(10)17-6-18-13/h3-4,6-7H,5H2,1-2H3,(H2,15,19)(H,16,17,18)/b9-3-
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TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254959
PNG
(US9505765, 182)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(=O)NC[C@H](C)O)c12
Show InChI InChI=1S/C16H22N4O3/c1-10(2)8-23-16-14-12(7-18-15(14)19-9-20-16)4-5-13(22)17-6-11(3)21/h4-5,7,9-11,21H,6,8H2,1-3H3,(H,17,22)(H,18,19,20)/b5-4+/t11-/m0/s1
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Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254943
PNG
(US9505765, 21)
Show SMILES CC(C)COc1ncnc2[nH]cc(C(C)=O)c12
Show InChI InChI=1S/C12H15N3O2/c1-7(2)5-17-12-10-9(8(3)16)4-13-11(10)14-6-15-12/h4,6-7H,5H2,1-3H3,(H,13,14,15)
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Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1


(Homo sapiens (Human))
BDBM254960
PNG
(US9505765, 183)
Show SMILES CC(C)COc1ncnc2[nH]cc(\C=C\C(=O)NC[C@@H](C)O)c12
Show InChI InChI=1S/C16H22N4O3/c1-10(2)8-23-16-14-12(7-18-15(14)19-9-20-16)4-5-13(22)17-6-11(3)21/h4-5,7,9-11,21H,6,8H2,1-3H3,(H,17,22)(H,18,19,20)/b5-4+/t11-/m1/s1
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Assay Description
TAK1-TAB1 Binding Inhibitory Potency: The ability of candidate compounds to interact with TAK1-TAB1 is quantitated by a competitive binding assay usi...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%