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Patent code US9505766

Compile Data Set for Download or QSAR
Found 158 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259863
PNG
(US9505766, 68)
Show SMILES CC(C)NS(=O)(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C22H26N6O3S/c1-14(2)27-32(30,31)17(12-23)11-18-19(16-7-5-15(3)6-8-16)20-21(24)25-13-26-22(20)28(18)9-4-10-29/h5-8,11,13-14,27,29H,4,9-10H2,1-3H3,(H2,24,25,26)/b17-11+
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UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259840
PNG
(US9505766, 44)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC2CC2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O2/c1-14-3-5-15(6-4-14)19-18(11-16(12-24)23(31)28-17-7-8-17)29(9-2-10-30)22-20(19)21(25)26-13-27-22/h3-6,11,13,17,30H,2,7-10H2,1H3,(H,28,31)(H2,25,26,27)/b16-11+
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UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259807
PNG
(US9505766, CN-NH2 (6))
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(N)=O)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C20H20N6O2/c1-12-3-5-13(6-4-12)16-15(9-14(10-21)19(23)28)26(7-2-8-27)20-17(16)18(22)24-11-25-20/h3-6,9,11,27H,2,7-8H2,1H3,(H2,23,28)(H2,22,24,25)/b14-9+
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US Patent
n/an/a 3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259876
PNG
(US9505766, 81)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)NC(C)(C)CO)cc12
Show InChI InChI=1S/C24H26N4O5/c1-24(2,13-29)26-23(30)16(12-25)8-14-6-7-18-17(9-14)21(28-27-18)15-10-19(31-3)22(33-5)20(11-15)32-4/h6-11,29H,13H2,1-5H3,(H,26,30)(H,27,28)/b16-8+
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n/an/a 3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259861
PNG
(US9505766, 66)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC(C)(CO)CO)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N6O4/c1-15-4-6-16(7-5-15)19-18(10-17(11-25)23(34)29-24(2,12-32)13-33)30(8-3-9-31)22-20(19)21(26)27-14-28-22/h4-7,10,14,31-33H,3,8-9,12-13H2,1-2H3,(H,29,34)(H2,26,27,28)/b17-10+
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UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259839
PNG
(US9505766, 43)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC(C)(C)CO)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N6O3/c1-15-5-7-16(8-6-15)19-18(11-17(12-25)23(33)29-24(2,3)13-32)30(9-4-10-31)22-20(19)21(26)27-14-28-22/h5-8,11,14,31-32H,4,9-10,13H2,1-3H3,(H,29,33)(H2,26,27,28)/b17-11+
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US Patent
n/an/a 3.80n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM50403059
PNG
(CHEMBL2216829 | US9505766, 64)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC(C)(C)C)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N6O2/c1-15-6-8-16(9-7-15)19-18(12-17(13-25)23(32)29-24(2,3)4)30(10-5-11-31)22-20(19)21(26)27-14-28-22/h6-9,12,14,31H,5,10-11H2,1-4H3,(H,29,32)(H2,26,27,28)/b17-12+
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UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259844
PNG
(US9505766, 48)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)N2CCC2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O2/c1-15-4-6-16(7-5-15)19-18(12-17(13-24)23(31)28-8-2-9-28)29(10-3-11-30)22-20(19)21(25)26-14-27-22/h4-7,12,14,30H,2-3,8-11H2,1H3,(H2,25,26,27)/b17-12+
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n/an/a 4.70n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259870
PNG
(US9505766, 75)
Show SMILES CN(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C22H25N7O2/c1-14-5-7-15(8-6-14)18-17(11-16(12-23)22(31)27-28(2)3)29(9-4-10-30)21-19(18)20(24)25-13-26-21/h5-8,11,13,30H,4,9-10H2,1-3H3,(H,27,31)(H2,24,25,26)/b16-11+
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US Patent
n/an/a 4.80n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259808
PNG
(US9505766, 74 | US9505766, CN-NHiPr (7))
Show SMILES CC(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C23H26N6O2/c1-14(2)28-23(31)17(12-24)11-18-19(16-7-5-15(3)6-8-16)20-21(25)26-13-27-22(20)29(18)9-4-10-30/h5-8,11,13-14,30H,4,9-10H2,1-3H3,(H,28,31)(H2,25,26,27)/b17-11+
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US Patent
n/an/a 5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259845
PNG
(US9505766, 49)
Show SMILES CN(C)C(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C22H24N6O2/c1-14-5-7-15(8-6-14)18-17(11-16(12-23)22(30)27(2)3)28(9-4-10-29)21-19(18)20(24)25-13-26-21/h5-8,11,13,29H,4,9-10H2,1-3H3,(H2,24,25,26)/b16-11+
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US Patent
n/an/a 6.5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259806
PNG
(US9505766, CN-OtBu (5))
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)OC(C)(C)C)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H27N5O3/c1-15-6-8-16(9-7-15)19-18(12-17(13-25)23(31)32-24(2,3)4)29(10-5-11-30)22-20(19)21(26)27-14-28-22/h6-9,12,14,30H,5,10-11H2,1-4H3,(H2,26,27,28)/b17-12+
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US Patent
n/an/a 7n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259858
PNG
(US9505766, 62)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)N2CCOCC2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H26N6O3/c1-16-3-5-17(6-4-16)20-19(13-18(14-25)24(32)29-8-11-33-12-9-29)30(7-2-10-31)23-21(20)22(26)27-15-28-23/h3-6,13,15,31H,2,7-12H2,1H3,(H2,26,27,28)/b18-13+
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n/an/a 10.5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259872
PNG
(US9505766, 77)
Show SMILES CONC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C21H22N6O3/c1-13-4-6-14(7-5-13)17-16(10-15(11-22)21(29)26-30-2)27(8-3-9-28)20-18(17)19(23)24-12-25-20/h4-7,10,12,28H,3,8-9H2,1-2H3,(H,26,29)(H2,23,24,25)/b15-10+
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US Patent
n/an/a 12.6n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259805
PNG
(US9505766, CN-OMe (4))
Show SMILES COC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C21H21N5O3/c1-13-4-6-14(7-5-13)17-16(10-15(11-22)21(28)29-2)26(8-3-9-27)20-18(17)19(23)24-12-25-20/h4-7,10,12,27H,3,8-9H2,1-2H3,(H2,23,24,25)/b15-10+
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US Patent
n/an/a 13n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259846
PNG
(US9505766, 50)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)N2CC(O)C2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O3/c1-14-3-5-15(6-4-14)19-18(9-16(10-24)23(32)28-11-17(31)12-28)29(7-2-8-30)22-20(19)21(25)26-13-27-22/h3-6,9,13,17,30-31H,2,7-8,11-12H2,1H3,(H2,25,26,27)/b16-9+
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US Patent
n/an/a 13.2n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259836
PNG
(US9505766, 40)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(N)=O)cc12
Show InChI InChI=1S/C20H18N4O4/c1-26-16-8-12(9-17(27-2)19(16)28-3)18-14-7-11(4-5-15(14)23-24-18)6-13(10-21)20(22)25/h4-9H,1-3H3,(H2,22,25)(H,23,24)/b13-6+
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n/an/a 14n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259837
PNG
(US9505766, 41)
Show SMILES CNC(=O)C(=C\c1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1)\C#N
Show InChI InChI=1S/C21H20N4O4/c1-23-21(26)14(11-22)7-12-5-6-16-15(8-12)19(25-24-16)13-9-17(27-2)20(29-4)18(10-13)28-3/h5-10H,1-4H3,(H,23,26)(H,24,25)/b14-7+
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n/an/a 14n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259862
PNG
(US9505766, 67)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)n2cncn2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N8O/c1-14-3-5-15(6-4-14)18-17(9-16(10-22)29-13-24-11-27-29)28(7-2-8-30)21-19(18)20(23)25-12-26-21/h3-6,9,11-13,30H,2,7-8H2,1H3,(H2,23,25,26)/b16-9+
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n/an/a 14.8n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259867
PNG
(US9505766, 72)
Show SMILES CN(CCO)C(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C23H26N6O3/c1-15-4-6-16(7-5-15)19-18(12-17(13-24)23(32)28(2)9-11-31)29(8-3-10-30)22-20(19)21(25)26-14-27-22/h4-7,12,14,30-31H,3,8-11H2,1-2H3,(H2,25,26,27)/b17-12+
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US Patent
n/an/a 17n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259875
PNG
(US9505766, 80)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)n2ccnn2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N8O/c1-14-3-5-15(6-4-14)18-17(11-16(12-22)29-9-7-26-27-29)28(8-2-10-30)21-19(18)20(23)24-13-25-21/h3-7,9,11,13,30H,2,8,10H2,1H3,(H2,23,24,25)/b16-11+
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n/an/a 20.9n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259842
PNG
(US9505766, 46)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)N2CCCC2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H26N6O2/c1-16-5-7-17(8-6-16)20-19(13-18(14-25)24(32)29-9-2-3-10-29)30(11-4-12-31)23-21(20)22(26)27-15-28-23/h5-8,13,15,31H,2-4,9-12H2,1H3,(H2,26,27,28)/b18-13+
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n/an/a 23.2n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259841
PNG
(US9505766, 45)
Show SMILES CCN(CC)C(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C24H28N6O2/c1-4-29(5-2)24(32)18(14-25)13-19-20(17-9-7-16(3)8-10-17)21-22(26)27-15-28-23(21)30(19)11-6-12-31/h7-10,13,15,31H,4-6,11-12H2,1-3H3,(H2,26,27,28)/b18-13+
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n/an/a 24.3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259868
PNG
(US9505766, 73)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC(C)(C)C(=O)OCC=C)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C27H30N6O4/c1-5-13-37-26(36)27(3,4)32-25(35)19(15-28)14-20-21(18-9-7-17(2)8-10-18)22-23(29)30-16-31-24(22)33(20)11-6-12-34/h5,7-10,14,16,34H,1,6,11-13H2,2-4H3,(H,32,35)(H2,29,30,31)/b19-14+
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n/an/a 26.1n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259873
PNG
(US9505766, 78)
Show SMILES Cc1csc(n1)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C23H22N6OS/c1-14-4-6-16(7-5-14)19-18(10-17(11-24)23-28-15(2)12-31-23)29(8-3-9-30)22-20(19)21(25)26-13-27-22/h4-7,10,12-13,30H,3,8-9H2,1-2H3,(H2,25,26,27)/b17-10+
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n/an/a 30.4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259855
PNG
(US9505766, 59)
Show SMILES NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C28H20N6O2/c29-15-20(27(31)35)13-18-5-4-6-21(14-18)34-16-24(25-26(30)32-17-33-28(25)34)19-9-11-23(12-10-19)36-22-7-2-1-3-8-22/h1-14,16-17H,(H2,31,35)(H2,30,32,33)/b20-13+
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n/an/a 40n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259809
PNG
(US9505766, CN-NHBn (8))
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NCc2ccccc2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C27H26N6O2/c1-18-8-10-20(11-9-18)23-22(33(12-5-13-34)26-24(23)25(29)31-17-32-26)14-21(15-28)27(35)30-16-19-6-3-2-4-7-19/h2-4,6-11,14,17,34H,5,12-13,16H2,1H3,(H,30,35)(H2,29,31,32)/b21-14+
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n/an/a 40n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259877
PNG
(US9505766, 82)
Show SMILES NC(=O)C(=C\c1ccc2[nH]nc(-c3cccnc3)c2c1)\C#N
Show InChI InChI=1S/C16H11N5O/c17-8-12(16(18)22)6-10-3-4-14-13(7-10)15(21-20-14)11-2-1-5-19-9-11/h1-7,9H,(H2,18,22)(H,20,21)/b12-6+
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n/an/a 41n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259860
PNG
(US9505766, 65)
Show SMILES CN(C)CCN(C)C(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C25H31N7O2/c1-17-6-8-18(9-7-17)21-20(14-19(15-26)25(34)31(4)12-11-30(2)3)32(10-5-13-33)24-22(21)23(27)28-16-29-24/h6-9,14,16,33H,5,10-13H2,1-4H3,(H2,27,28,29)/b19-14+
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n/an/a 41.3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259843
PNG
(US9505766, 47)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C25H29N7O2/c1-17-4-6-18(7-5-17)21-20(14-19(15-26)25(34)31-11-9-30(2)10-12-31)32(8-3-13-33)24-22(21)23(27)28-16-29-24/h4-7,14,16,33H,3,8-13H2,1-2H3,(H2,27,28,29)/b19-14+
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n/an/a 41.3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259854
PNG
(US9505766, 58)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CC(O)C2)c1
Show InChI InChI=1S/C31H24N6O3/c32-15-22(31(39)36-16-24(38)17-36)13-20-5-4-6-23(14-20)37-18-27(28-29(33)34-19-35-30(28)37)21-9-11-26(12-10-21)40-25-7-2-1-3-8-25/h1-14,18-19,24,38H,16-17H2,(H2,33,34,35)/b22-13+
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n/an/a 70n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259859
PNG
(US9505766, 63)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)c2ccncc2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N6O/c1-16-3-5-18(6-4-16)21-20(13-19(14-25)17-7-9-27-10-8-17)30(11-2-12-31)24-22(21)23(26)28-15-29-24/h3-10,13,15,31H,2,11-12H2,1H3,(H2,26,28,29)/b19-13+
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n/an/a 71n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259878
PNG
(US9505766, 83)
Show SMILES CC(C)(CO)NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C32H28N6O3/c1-32(2,19-39)37-31(40)23(17-33)15-21-7-6-8-24(16-21)38-18-27(28-29(34)35-20-36-30(28)38)22-11-13-26(14-12-22)41-25-9-4-3-5-10-25/h3-16,18,20,39H,19H2,1-2H3,(H,37,40)(H2,34,35,36)/b23-15+
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n/an/a 80n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259848
PNG
(US9505766, 52)
Show SMILES CN(C)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C24H19ClN6O/c1-30(2)24(32)17(12-26)10-15-4-3-5-19(11-15)31-13-20(16-6-8-18(25)9-7-16)21-22(27)28-14-29-23(21)31/h3-11,13-14H,1-2H3,(H2,27,28,29)/b17-10+
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n/an/a 80n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259802
PNG
(US9505766, Me enone (1))
Show SMILES CC(=O)\C=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO
Show InChI InChI=1S/C20H22N4O2/c1-13-4-7-15(8-5-13)17-16(9-6-14(2)26)24(10-3-11-25)20-18(17)19(21)22-12-23-20/h4-9,12,25H,3,10-11H2,1-2H3,(H2,21,22,23)/b9-6+
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n/an/a 87n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259838
PNG
(US9505766, 42)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)N(C)C)cc12
Show InChI InChI=1S/C22H22N4O4/c1-26(2)22(27)15(12-23)8-13-6-7-17-16(9-13)20(25-24-17)14-10-18(28-3)21(30-5)19(11-14)29-4/h6-11H,1-5H3,(H,24,25)/b15-8+
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n/an/a 89n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259847
PNG
(US9505766, 51)
Show SMILES NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C22H15ClN6O/c23-16-6-4-14(5-7-16)18-11-29(22-19(18)20(25)27-12-28-22)17-3-1-2-13(9-17)8-15(10-24)21(26)30/h1-9,11-12H,(H2,26,30)(H2,25,27,28)/b15-8+
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n/an/a 90n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259816
PNG
(US9505766, 16)
Show SMILES CNC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C12H10N4O/c1-14-12(17)10(6-13)4-8-2-3-9-7-15-16-11(9)5-8/h2-5,7H,1H3,(H,14,17)(H,15,16)/b10-4+
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n/an/a 92n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259811
PNG
(US9505766, 11)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+
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n/an/a 109n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259812
PNG
(US9505766, 12)
Show SMILES NC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C18H12N4O2/c19-9-13(17(20)24)8-11-3-1-4-12(7-11)16(23)15-10-22-18-14(15)5-2-6-21-18/h1-8,10H,(H2,20,24)(H,21,22)/b13-8+
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n/an/a 124n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259830
PNG
(US9505766, 34)
Show SMILES CNC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C12H10N4O/c1-14-12(17)9(6-13)4-8-2-3-11-10(5-8)7-15-16-11/h2-5,7H,1H3,(H,14,17)(H,15,16)/b9-4+
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n/an/a 129n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259848
PNG
(US9505766, 52)
Show SMILES CN(C)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C24H19ClN6O/c1-30(2)24(32)17(12-26)10-15-4-3-5-19(11-15)31-13-20(16-6-8-18(25)9-7-16)21-22(27)28-14-29-23(21)31/h3-11,13-14H,1-2H3,(H2,27,28,29)/b17-10+
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n/an/a 130n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM259848
PNG
(US9505766, 52)
Show SMILES CN(C)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C24H19ClN6O/c1-30(2)24(32)17(12-26)10-15-4-3-5-19(11-15)31-13-20(16-6-8-18(25)9-7-16)21-22(27)28-14-29-23(21)31/h3-11,13-14H,1-2H3,(H2,27,28,29)/b17-10+
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n/an/a 141n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259828
PNG
(US9505766, 32)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)c2ccccn2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N6O/c1-16-6-8-17(9-7-16)21-20(13-18(14-25)19-5-2-3-10-27-19)30(11-4-12-31)24-22(21)23(26)28-15-29-24/h2-3,5-10,13,15,31H,4,11-12H2,1H3,(H2,26,28,29)/b18-13+
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n/an/a 142n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259815
PNG
(US9505766, 15)
Show SMILES NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-9(11(13)16)3-7-1-2-8-6-14-15-10(8)4-7/h1-4,6H,(H2,13,16)(H,14,15)/b9-3+
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n/an/a 183n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259836
PNG
(US9505766, 40)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(N)=O)cc12
Show InChI InChI=1S/C20H18N4O4/c1-26-16-8-12(9-17(27-2)19(16)28-3)18-14-7-11(4-5-15(14)23-24-18)6-13(10-21)20(22)25/h4-9H,1-3H3,(H2,22,25)(H,23,24)/b13-6+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259804
PNG
(US9505766, Me acrylate (2))
Show SMILES COC(=O)\C=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO
Show InChI InChI=1S/C20H22N4O3/c1-13-4-6-14(7-5-13)17-15(8-9-16(26)27-2)24(10-3-11-25)20-18(17)19(21)22-12-23-20/h4-9,12,25H,3,10-11H2,1-2H3,(H2,21,22,23)/b9-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259819
PNG
(US9505766, 20)
Show SMILES CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H11N5O2S/c1-23(21,22)12(7-16)6-10-2-4-11(5-3-10)13-14-15(19-8-17-13)20-9-18-14/h2-6,8-9H,1H3,(H,17,18,19,20)/b12-6+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259818
PNG
(US9505766, 18)
Show SMILES NC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C14H15N7O/c15-6-10(12(16)22)5-9-1-3-21(4-2-9)14-11-13(18-7-17-11)19-8-20-14/h5,7-9H,1-4H2,(H2,16,22)(H,17,18,19,20)/b10-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259871
PNG
(US9505766, 76)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)c2cccnc2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N6O/c1-16-5-7-17(8-6-16)21-20(12-19(13-25)18-4-2-9-27-14-18)30(10-3-11-31)24-22(21)23(26)28-15-29-24/h2,4-9,12,14-15,31H,3,10-11H2,1H3,(H2,26,28,29)/b19-12+
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n/an/a 224n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259852
PNG
(US9505766, 56)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C27H24ClN7O/c1-33-9-11-34(12-10-33)27(36)20(15-29)13-18-3-2-4-22(14-18)35-16-23(19-5-7-21(28)8-6-19)24-25(30)31-17-32-26(24)35/h2-8,13-14,16-17H,9-12H2,1H3,(H2,30,31,32)/b20-13+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259856
PNG
(US9505766, 60)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)NCCO)c1
Show InChI InChI=1S/C30H24N6O3/c31-17-22(30(38)33-13-14-37)15-20-5-4-6-23(16-20)36-18-26(27-28(32)34-19-35-29(27)36)21-9-11-25(12-10-21)39-24-7-2-1-3-8-24/h1-12,15-16,18-19,37H,13-14H2,(H,33,38)(H2,32,34,35)/b22-15+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259813
PNG
(US9505766, 13)
Show SMILES NC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-8(11(13)16)3-7-1-2-10-9(4-7)6-14-15-10/h1-4,6H,(H2,13,16)(H,14,15)/b8-3+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259804
PNG
(US9505766, Me acrylate (2))
Show SMILES COC(=O)\C=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO
Show InChI InChI=1S/C20H22N4O3/c1-13-4-6-14(7-5-13)17-15(8-9-16(26)27-2)24(10-3-11-25)20-18(17)19(21)22-12-23-20/h4-9,12,25H,3,10-11H2,1-2H3,(H2,21,22,23)/b9-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM259847
PNG
(US9505766, 51)
Show SMILES NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C22H15ClN6O/c23-16-6-4-14(5-7-16)18-11-29(22-19(18)20(25)27-12-28-22)17-3-1-2-13(9-17)8-15(10-24)21(26)30/h1-9,11-12H,(H2,26,30)(H2,25,27,28)/b15-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259874
PNG
(US9505766, 79)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)n2cccn2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C22H21N7O/c1-15-4-6-16(7-5-15)19-18(12-17(13-23)29-10-2-8-27-29)28(9-3-11-30)22-20(19)21(24)25-14-26-22/h2,4-8,10,12,14,30H,3,9,11H2,1H3,(H2,24,25,26)/b17-12+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259854
PNG
(US9505766, 58)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CC(O)C2)c1
Show InChI InChI=1S/C31H24N6O3/c32-15-22(31(39)36-16-24(38)17-36)13-20-5-4-6-23(14-20)37-18-27(28-29(33)34-19-35-30(28)37)21-9-11-26(12-10-21)40-25-7-2-1-3-8-25/h1-14,18-19,24,38H,16-17H2,(H2,33,34,35)/b22-13+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259834
PNG
(US9505766, 38)
Show SMILES CNC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C19H14N4O2/c1-21-19(25)14(10-20)9-12-4-2-5-13(8-12)17(24)16-11-23-18-15(16)6-3-7-22-18/h2-9,11H,1H3,(H,21,25)(H,22,23)/b14-9+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259832
PNG
(US9505766, 36)
Show SMILES CNC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H17N7O/c1-17-15(23)11(7-16)6-10-2-4-22(5-3-10)14-12-13(19-8-18-12)20-9-21-14/h6,8-10H,2-5H2,1H3,(H,17,23)(H,18,19,20,21)/b11-6+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259851
PNG
(US9505766, 55)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CC(O)C2)c1
Show InChI InChI=1S/C25H19ClN6O2/c26-18-6-4-16(5-7-18)21-13-32(24-22(21)23(28)29-14-30-24)19-3-1-2-15(9-19)8-17(10-27)25(34)31-11-20(33)12-31/h1-9,13-14,20,33H,11-12H2,(H2,28,29,30)/b17-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259831
PNG
(US9505766, 35)
Show SMILES CC(C)NC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C14H14N4O/c1-9(2)17-14(19)11(7-15)5-10-3-4-13-12(6-10)8-16-18-13/h3-6,8-9H,1-2H3,(H,16,18)(H,17,19)/b11-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259864
PNG
(US9505766, 69)
Show SMILES Cc1ccc(cc1)-c1c(C(=O)C(F)F)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C18H18F2N4O2/c1-10-3-5-11(6-4-10)12-13-17(21)22-9-23-18(13)24(7-2-8-25)14(12)15(26)16(19)20/h3-6,9,16,25H,2,7-8H2,1H3,(H2,21,22,23)
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259865
PNG
(US9505766, 70)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC23CC4CC(CC(C4)C2)C3)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C30H34N6O2/c1-18-3-5-22(6-4-18)25-24(36(7-2-8-37)28-26(25)27(32)33-17-34-28)12-23(16-31)29(38)35-30-13-19-9-20(14-30)11-21(10-19)15-30/h3-6,12,17,19-21,37H,2,7-11,13-15H2,1H3,(H,35,38)(H2,32,33,34)/b23-12+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259866
PNG
(US9505766, 71)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)c2cc[n+]([O-])cc2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N6O2/c1-16-3-5-18(6-4-16)21-20(13-19(14-25)17-7-10-29(32)11-8-17)30(9-2-12-31)24-22(21)23(26)27-15-28-24/h3-8,10-11,13,15,31H,2,9,12H2,1H3,(H2,26,27,28)/b19-13+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259808
PNG
(US9505766, 74 | US9505766, CN-NHiPr (7))
Show SMILES CC(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C23H26N6O2/c1-14(2)28-23(31)17(12-24)11-18-19(16-7-5-15(3)6-8-16)20-21(25)26-13-27-22(20)29(18)9-4-10-30/h5-8,11,13-14,30H,4,9-10H2,1-3H3,(H,28,31)(H2,25,26,27)/b17-11+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259847
PNG
(US9505766, 51)
Show SMILES NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C22H15ClN6O/c23-16-6-4-14(5-7-16)18-11-29(22-19(18)20(25)27-12-28-22)17-3-1-2-13(9-17)8-15(10-24)21(26)30/h1-9,11-12H,(H2,26,30)(H2,25,27,28)/b15-8+
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n/an/a 520n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259853
PNG
(US9505766, 57)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C33H29N7O2/c1-38-14-16-39(17-15-38)33(41)25(20-34)18-23-6-5-7-26(19-23)40-21-29(30-31(35)36-22-37-32(30)40)24-10-12-28(13-11-24)42-27-8-3-2-4-9-27/h2-13,18-19,21-22H,14-17H2,1H3,(H2,35,36,37)/b25-18+
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n/an/a 620n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259857
PNG
(US9505766, 61)
Show SMILES CN(C)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C30H24N6O2/c1-35(2)30(37)22(17-31)15-20-7-6-8-23(16-20)36-18-26(27-28(32)33-19-34-29(27)36)21-11-13-25(14-12-21)38-24-9-4-3-5-10-24/h3-16,18-19H,1-2H3,(H2,32,33,34)/b22-15+
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n/an/a 630n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259817
PNG
(US9505766, 17)
Show SMILES CC(C)NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C14H14N4O/c1-9(2)17-14(19)12(7-15)5-10-3-4-11-8-16-18-13(11)6-10/h3-6,8-9H,1-2H3,(H,16,18)(H,17,19)/b12-5+
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n/an/a 630n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM259848
PNG
(US9505766, 52)
Show SMILES CN(C)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C24H19ClN6O/c1-30(2)24(32)17(12-26)10-15-4-3-5-19(11-15)31-13-20(16-6-8-18(25)9-7-16)21-22(27)28-14-29-23(21)31/h3-11,13-14H,1-2H3,(H2,27,28,29)/b17-10+
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n/an/a 640n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259836
PNG
(US9505766, 40)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(N)=O)cc12
Show InChI InChI=1S/C20H18N4O4/c1-26-16-8-12(9-17(27-2)19(16)28-3)18-14-7-11(4-5-15(14)23-24-18)6-13(10-21)20(22)25/h4-9H,1-3H3,(H2,22,25)(H,23,24)/b13-6+
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n/an/a 650n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259837
PNG
(US9505766, 41)
Show SMILES CNC(=O)C(=C\c1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1)\C#N
Show InChI InChI=1S/C21H20N4O4/c1-23-21(26)14(11-22)7-12-5-6-16-15(8-12)19(25-24-16)13-9-17(27-2)20(29-4)18(10-13)28-3/h5-10H,1-4H3,(H,23,26)(H,24,25)/b14-7+
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n/an/a 650n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 (781-1124)


(Homo sapiens (human))
BDBM259852
PNG
(US9505766, 56)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C27H24ClN7O/c1-33-9-11-34(12-10-33)27(36)20(15-29)13-18-3-2-4-22(14-18)35-16-23(19-5-7-21(28)8-6-19)24-25(30)31-17-32-26(24)35/h2-8,13-14,16-17H,9-12H2,1H3,(H2,30,31,32)/b20-13+
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n/an/a 660n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent




Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259851
PNG
(US9505766, 55)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CC(O)C2)c1
Show InChI InChI=1S/C25H19ClN6O2/c26-18-6-4-16(5-7-18)21-13-32(24-22(21)23(28)29-14-30-24)19-3-1-2-15(9-19)8-17(10-27)25(34)31-11-20(33)12-31/h1-9,13-14,20,33H,11-12H2,(H2,28,29,30)/b17-8+
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n/an/a 700n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259833
PNG
(US9505766, 37)
Show SMILES CN(C)C(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C13H12N4O/c1-17(2)13(18)10(7-14)5-9-3-4-12-11(6-9)8-15-16-12/h3-6,8H,1-2H3,(H,15,16)/b10-5+
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n/an/a 747n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259811
PNG
(US9505766, 11)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+
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n/an/a<750n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259803
PNG
(US9505766, acrylonitrile (3))
Show SMILES Cc1ccc(cc1)-c1c(\C=C\C#N)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O/c1-13-5-7-14(8-6-13)16-15(4-2-9-20)24(10-3-11-25)19-17(16)18(21)22-12-23-19/h2,4-8,12,25H,3,10-11H2,1H3,(H2,21,22,23)/b4-2+
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n/an/a 750n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259818
PNG
(US9505766, 18)
Show SMILES NC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C14H15N7O/c15-6-10(12(16)22)5-9-1-3-21(4-2-9)14-11-13(18-7-17-11)19-8-20-14/h5,7-9H,1-4H2,(H2,16,22)(H,17,18,19,20)/b10-5+
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n/an/a 758n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259850
PNG
(US9505766, 54)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CCCC2)c1
Show InChI InChI=1S/C26H21ClN6O/c27-20-8-6-18(7-9-20)22-15-33(25-23(22)24(29)30-16-31-25)21-5-3-4-17(13-21)12-19(14-28)26(34)32-10-1-2-11-32/h3-9,12-13,15-16H,1-2,10-11H2,(H2,29,30,31)/b19-12+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259810
PNG
(US9505766, 10)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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n/an/a 900n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259814
PNG
(US9505766, 14)
Show SMILES O=C(N1CCCC1)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C15H14N4O/c16-9-12(15(20)19-5-1-2-6-19)7-11-3-4-14-13(8-11)10-17-18-14/h3-4,7-8,10H,1-2,5-6H2,(H,17,18)/b12-7+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259822
PNG
(US9505766, 23)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-2-1-3-10(4-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259811
PNG
(US9505766, 11)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259820
PNG
(US9505766, 21)
Show SMILES O=S(=O)(C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N)c1ccccc1
Show InChI InChI=1S/C20H13N5O2S/c21-11-17(28(26,27)16-4-2-1-3-5-16)10-14-6-8-15(9-7-14)18-19-20(24-12-22-18)25-13-23-19/h1-10,12-13H,(H,22,23,24,25)/b17-10+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259825
PNG
(US9505766, 29)
Show SMILES CS(=O)(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C18H13N3O3S/c1-25(23,24)14(10-19)9-12-4-2-5-13(8-12)17(22)16-11-21-18-15(16)6-3-7-20-18/h2-9,11H,1H3,(H,20,21)/b14-9+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259825
PNG
(US9505766, 29)
Show SMILES CS(=O)(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C18H13N3O3S/c1-25(23,24)14(10-19)9-12-4-2-5-13(8-12)17(22)16-11-21-18-15(16)6-3-7-20-18/h2-9,11H,1H3,(H,20,21)/b14-9+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259837
PNG
(US9505766, 41)
Show SMILES CNC(=O)C(=C\c1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1)\C#N
Show InChI InChI=1S/C21H20N4O4/c1-23-21(26)14(11-22)7-12-5-6-16-15(8-12)19(25-24-16)13-9-17(27-2)20(29-4)18(10-13)28-3/h5-10H,1-4H3,(H,23,26)(H,24,25)/b14-7+
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n/an/a 1.14E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259852
PNG
(US9505766, 56)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C27H24ClN7O/c1-33-9-11-34(12-10-33)27(36)20(15-29)13-18-3-2-4-22(14-18)35-16-23(19-5-7-21(28)8-6-19)24-25(30)31-17-32-26(24)35/h2-8,13-14,16-17H,9-12H2,1H3,(H2,30,31,32)/b20-13+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259803
PNG
(US9505766, acrylonitrile (3))
Show SMILES Cc1ccc(cc1)-c1c(\C=C\C#N)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O/c1-13-5-7-14(8-6-13)16-15(4-2-9-20)24(10-3-11-25)19-17(16)18(21)22-12-23-19/h2,4-8,12,25H,3,10-11H2,1H3,(H2,21,22,23)/b4-2+
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UniChem
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM259849
PNG
(US9505766, 53)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CCC2)c1
Show InChI InChI=1S/C25H19ClN6O/c26-19-7-5-17(6-8-19)21-14-32(24-22(21)23(28)29-15-30-24)20-4-1-3-16(12-20)11-18(13-27)25(33)31-9-2-10-31/h1,3-8,11-12,14-15H,2,9-10H2,(H2,28,29,30)/b18-11+
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n/an/a 1.50E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259802
PNG
(US9505766, Me enone (1))
Show SMILES CC(=O)\C=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO
Show InChI InChI=1S/C20H22N4O2/c1-13-4-7-15(8-5-13)17-16(9-6-14(2)26)24(10-3-11-25)20-18(17)19(21)22-12-23-20/h4-9,12,25H,3,10-11H2,1-2H3,(H2,21,22,23)/b9-6+
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n/an/a 1.70E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259835
PNG
(US9505766, 39)
Show SMILES CN(C)C(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C20H16N4O2/c1-24(2)20(26)15(11-21)10-13-5-3-6-14(9-13)18(25)17-12-23-19-16(17)7-4-8-22-19/h3-10,12H,1-2H3,(H,22,23)/b15-10+
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US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259853
PNG
(US9505766, 57)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C33H29N7O2/c1-38-14-16-39(17-15-38)33(41)25(20-34)18-23-6-5-7-26(19-23)40-21-29(30-31(35)36-22-37-32(30)40)24-10-12-28(13-11-24)42-27-8-3-2-4-9-27/h2-13,18-19,21-22H,14-17H2,1H3,(H2,35,36,37)/b25-18+
PDB

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UniChem
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259849
PNG
(US9505766, 53)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CCC2)c1
Show InChI InChI=1S/C25H19ClN6O/c26-19-7-5-17(6-8-19)21-14-32(24-22(21)23(28)29-15-30-24)20-4-1-3-16(12-20)11-18(13-27)25(33)31-9-2-10-31/h1,3-8,11-12,14-15H,2,9-10H2,(H2,28,29,30)/b18-11+
PDB

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US Patent
n/an/a 2.50E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259824
PNG
(US9505766, 25)
Show SMILES O=C(N1CCCC1)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C15H14N4O/c16-9-13(15(20)19-5-1-2-6-19)7-11-3-4-12-10-17-18-14(12)8-11/h3-4,7-8,10H,1-2,5-6H2,(H,17,18)/b13-7+
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US Patent
n/an/a 2.60E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259815
PNG
(US9505766, 15)
Show SMILES NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-9(11(13)16)3-7-1-2-8-6-14-15-10(8)4-7/h1-4,6H,(H2,13,16)(H,14,15)/b9-3+
PDB

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US Patent
n/an/a 3.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259813
PNG
(US9505766, 13)
Show SMILES NC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-8(11(13)16)3-7-1-2-10-9(4-7)6-14-15-10/h1-4,6H,(H2,13,16)(H,14,15)/b8-3+
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n/an/a 3.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259812
PNG
(US9505766, 12)
Show SMILES NC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C18H12N4O2/c19-9-13(17(20)24)8-11-3-1-4-12(7-11)16(23)15-10-22-18-14(15)5-2-6-21-18/h1-8,10H,(H2,20,24)(H,21,22)/b13-8+
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n/an/a 3.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259822
PNG
(US9505766, 23)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-2-1-3-10(4-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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n/an/a 3.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259838
PNG
(US9505766, 42)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)N(C)C)cc12
Show InChI InChI=1S/C22H22N4O4/c1-26(2)22(27)15(12-23)8-13-6-7-17-16(9-13)20(25-24-17)14-10-18(28-3)21(30-5)19(11-14)29-4/h6-11H,1-5H3,(H,24,25)/b15-8+
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n/an/a 3.80E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM259852
PNG
(US9505766, 56)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C27H24ClN7O/c1-33-9-11-34(12-10-33)27(36)20(15-29)13-18-3-2-4-22(14-18)35-16-23(19-5-7-21(28)8-6-19)24-25(30)31-17-32-26(24)35/h2-8,13-14,16-17H,9-12H2,1H3,(H2,30,31,32)/b20-13+
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n/an/a>5.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259823
PNG
(US9505766, 24)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1cn[nH]c1)\C#N
Show InChI InChI=1S/C13H10N4O/c14-6-11(13(15)18)5-9-1-3-10(4-2-9)12-7-16-17-8-12/h1-5,7-8H,(H2,15,18)(H,16,17)/b11-5+
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US Patent
n/an/a 5.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259807
PNG
(US9505766, CN-NH2 (6))
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(N)=O)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C20H20N6O2/c1-12-3-5-13(6-4-12)16-15(9-14(10-21)19(23)28)26(7-2-8-27)20-17(16)18(22)24-11-25-20/h3-6,9,11,27H,2,7-8H2,1H3,(H2,23,28)(H2,22,24,25)/b14-9+
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n/an/a 5.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM259849
PNG
(US9505766, 53)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CCC2)c1
Show InChI InChI=1S/C25H19ClN6O/c26-19-7-5-17(6-8-19)21-14-32(24-22(21)23(28)29-15-30-24)20-4-1-3-16(12-20)11-18(13-27)25(33)31-9-2-10-31/h1,3-8,11-12,14-15H,2,9-10H2,(H2,28,29,30)/b18-11+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM259851
PNG
(US9505766, 55)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CC(O)C2)c1
Show InChI InChI=1S/C25H19ClN6O2/c26-18-6-4-16(5-7-18)21-13-32(24-22(21)23(28)29-14-30-24)19-3-1-2-15(9-19)8-17(10-27)25(34)31-11-20(33)12-31/h1-9,13-14,20,33H,11-12H2,(H2,28,29,30)/b17-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259810
PNG
(US9505766, 10)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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n/an/a 5.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259808
PNG
(US9505766, 74 | US9505766, CN-NHiPr (7))
Show SMILES CC(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C23H26N6O2/c1-14(2)28-23(31)17(12-24)11-18-19(16-7-5-15(3)6-8-16)20-21(25)26-13-27-22(20)29(18)9-4-10-30/h5-8,11,13-14,30H,4,9-10H2,1-3H3,(H,28,31)(H2,25,26,27)/b17-11+
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n/an/a 5.50E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM259847
PNG
(US9505766, 51)
Show SMILES NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C22H15ClN6O/c23-16-6-4-14(5-7-16)18-11-29(22-19(18)20(25)27-12-28-22)17-3-1-2-13(9-17)8-15(10-24)21(26)30/h1-9,11-12H,(H2,26,30)(H2,25,27,28)/b15-8+
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n/an/a 5.90E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259824
PNG
(US9505766, 25)
Show SMILES O=C(N1CCCC1)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C15H14N4O/c16-9-13(15(20)19-5-1-2-6-19)7-11-3-4-12-10-17-18-14(12)8-11/h3-4,7-8,10H,1-2,5-6H2,(H,17,18)/b13-7+
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n/an/a 6.50E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259821
PNG
(US9505766, 22)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+
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n/an/a 8.00E+3n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM259847
PNG
(US9505766, 51)
Show SMILES NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C22H15ClN6O/c23-16-6-4-14(5-7-16)18-11-29(22-19(18)20(25)27-12-28-22)17-3-1-2-13(9-17)8-15(10-24)21(26)30/h1-9,11-12H,(H2,26,30)(H2,25,27,28)/b15-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259822
PNG
(US9505766, 23)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-2-1-3-10(4-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


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More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259805
PNG
(US9505766, CN-OMe (4))
Show SMILES COC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C21H21N5O3/c1-13-4-6-14(7-5-13)17-16(10-15(11-22)21(28)29-2)26(8-3-9-27)20-18(17)19(23)24-12-25-20/h4-7,10,12,27H,3,8-9H2,1-2H3,(H2,23,24,25)/b15-10+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259813
PNG
(US9505766, 13)
Show SMILES NC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-8(11(13)16)3-7-1-2-10-9(4-7)6-14-15-10/h1-4,6H,(H2,13,16)(H,14,15)/b8-3+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259819
PNG
(US9505766, 20)
Show SMILES CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H11N5O2S/c1-23(21,22)12(7-16)6-10-2-4-11(5-3-10)13-14-15(19-8-17-13)20-9-18-14/h2-6,8-9H,1H3,(H,17,18,19,20)/b12-6+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259818
PNG
(US9505766, 18)
Show SMILES NC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C14H15N7O/c15-6-10(12(16)22)5-9-1-3-21(4-2-9)14-11-13(18-7-17-11)19-8-20-14/h5,7-9H,1-4H2,(H2,16,22)(H,17,18,19,20)/b10-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259815
PNG
(US9505766, 15)
Show SMILES NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-9(11(13)16)3-7-1-2-8-6-14-15-10(8)4-7/h1-4,6H,(H2,13,16)(H,14,15)/b9-3+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259821
PNG
(US9505766, 22)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259806
PNG
(US9505766, CN-OtBu (5))
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)OC(C)(C)C)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H27N5O3/c1-15-6-8-16(9-7-15)19-18(12-17(13-25)23(31)32-24(2,3)4)29(10-5-11-30)22-20(19)21(26)27-14-28-22/h6-9,12,14,30H,5,10-11H2,1-4H3,(H2,26,27,28)/b17-12+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Proto-oncogene c-Src (S345C)


(Homo sapiens (Human))
BDBM259878
PNG
(US9505766, 83)
Show SMILES CC(C)(CO)NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C32H28N6O3/c1-32(2,19-39)37-31(40)23(17-33)15-21-7-6-8-24(16-21)38-18-27(28-29(34)35-20-36-30(28)38)22-11-13-26(14-12-22)41-25-9-4-3-5-10-25/h3-16,18,20,39H,19H2,1-2H3,(H,37,40)(H2,34,35,36)/b23-15+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259823
PNG
(US9505766, 24)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1cn[nH]c1)\C#N
Show InChI InChI=1S/C13H10N4O/c14-6-11(13(15)18)5-9-1-3-10(4-2-9)12-7-16-17-8-12/h1-5,7-8H,(H2,15,18)(H,16,17)/b11-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259814
PNG
(US9505766, 14)
Show SMILES O=C(N1CCCC1)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C15H14N4O/c16-9-12(15(20)19-5-1-2-6-19)7-11-3-4-14-13(8-11)10-17-18-14/h3-4,7-8,10H,1-2,5-6H2,(H,17,18)/b12-7+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259820
PNG
(US9505766, 21)
Show SMILES O=S(=O)(C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N)c1ccccc1
Show InChI InChI=1S/C20H13N5O2S/c21-11-17(28(26,27)16-4-2-1-3-5-16)10-14-6-8-15(9-7-14)18-19-20(24-12-22-18)25-13-23-19/h1-10,12-13H,(H,22,23,24,25)/b17-10+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259817
PNG
(US9505766, 17)
Show SMILES CC(C)NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C14H14N4O/c1-9(2)17-14(19)12(7-15)5-10-3-4-11-8-16-18-13(11)6-10/h3-6,8-9H,1-2H3,(H,16,18)(H,17,19)/b12-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259828
PNG
(US9505766, 32)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)c2ccccn2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C24H22N6O/c1-16-6-8-17(9-7-16)21-20(13-18(14-25)19-5-2-3-10-27-19)30(11-4-12-31)24-22(21)23(26)28-15-29-24/h2-3,5-10,13,15,31H,4,11-12H2,1H3,(H2,26,28,29)/b18-13+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259812
PNG
(US9505766, 12)
Show SMILES NC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C18H12N4O2/c19-9-13(17(20)24)8-11-3-1-4-12(7-11)16(23)15-10-22-18-14(15)5-2-6-21-18/h1-8,10H,(H2,20,24)(H,21,22)/b13-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259811
PNG
(US9505766, 11)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259810
PNG
(US9505766, 10)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM259878
PNG
(US9505766, 83)
Show SMILES CC(C)(CO)NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C32H28N6O3/c1-32(2,19-39)37-31(40)23(17-33)15-21-7-6-8-24(16-21)38-18-27(28-29(34)35-20-36-30(28)38)22-11-13-26(14-12-22)41-25-9-4-3-5-10-25/h3-16,18,20,39H,19H2,1-2H3,(H,37,40)(H2,34,35,36)/b23-15+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM259852
PNG
(US9505766, 56)
Show SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C27H24ClN7O/c1-33-9-11-34(12-10-33)27(36)20(15-29)13-18-3-2-4-22(14-18)35-16-23(19-5-7-21(28)8-6-19)24-25(30)31-17-32-26(24)35/h2-8,13-14,16-17H,9-12H2,1H3,(H2,30,31,32)/b20-13+
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Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259838
PNG
(US9505766, 42)
Show SMILES COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)N(C)C)cc12
Show InChI InChI=1S/C22H22N4O4/c1-26(2)22(27)15(12-23)8-13-6-7-17-16(9-13)20(25-24-17)14-10-18(28-3)21(30-5)19(11-14)29-4/h6-11H,1-5H3,(H,24,25)/b15-8+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259829
PNG
(US9505766, 33)
Show SMILES NC(=O)C(=C\c1nc2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C12H13N7O2/c13-5-7(11(15)21)4-8-18-9-10(14)16-6-17-12(9)19(8)2-1-3-20/h4,6,20H,1-3H2,(H2,15,21)(H2,14,16,17)/b7-4+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM259848
PNG
(US9505766, 52)
Show SMILES CN(C)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
Show InChI InChI=1S/C24H19ClN6O/c1-30(2)24(32)17(12-26)10-15-4-3-5-19(11-15)31-13-20(16-6-8-18(25)9-7-16)21-22(27)28-14-29-23(21)31/h3-11,13-14H,1-2H3,(H2,27,28,29)/b17-10+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259829
PNG
(US9505766, 33)
Show SMILES NC(=O)C(=C\c1nc2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C12H13N7O2/c13-5-7(11(15)21)4-8-18-9-10(14)16-6-17-12(9)19(8)2-1-3-20/h4,6,20H,1-3H2,(H2,15,21)(H2,14,16,17)/b7-4+
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n/an/a 1.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259827
PNG
(US9505766, 31)
Show SMILES CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+
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n/an/a 2.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259810
PNG
(US9505766, 10)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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n/an/a 3.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259827
PNG
(US9505766, 31)
Show SMILES CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+
PDB

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n/an/a 4.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259812
PNG
(US9505766, 12)
Show SMILES NC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C18H12N4O2/c19-9-13(17(20)24)8-11-3-1-4-12(7-11)16(23)15-10-22-18-14(15)5-2-6-21-18/h1-8,10H,(H2,20,24)(H,21,22)/b13-8+
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n/an/a 4.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259820
PNG
(US9505766, 21)
Show SMILES O=S(=O)(C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N)c1ccccc1
Show InChI InChI=1S/C20H13N5O2S/c21-11-17(28(26,27)16-4-2-1-3-5-16)10-14-6-8-15(9-7-14)18-19-20(24-12-22-18)25-13-23-19/h1-10,12-13H,(H,22,23,24,25)/b17-10+
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n/an/a 6.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259819
PNG
(US9505766, 20)
Show SMILES CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H11N5O2S/c1-23(21,22)12(7-16)6-10-2-4-11(5-3-10)13-14-15(19-8-17-13)20-9-18-14/h2-6,8-9H,1H3,(H,17,18,19,20)/b12-6+
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n/an/a 6.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259829
PNG
(US9505766, 33)
Show SMILES NC(=O)C(=C\c1nc2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C12H13N7O2/c13-5-7(11(15)21)4-8-18-9-10(14)16-6-17-12(9)19(8)2-1-3-20/h4,6,20H,1-3H2,(H2,15,21)(H2,14,16,17)/b7-4+
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n/an/a 8.00E+4n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259810
PNG
(US9505766, 10)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N
Show InChI InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+
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n/an/a 1.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259821
PNG
(US9505766, 22)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+
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n/an/a 1.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259811
PNG
(US9505766, 11)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N
Show InChI InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+
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n/an/a 1.50E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259813
PNG
(US9505766, 13)
Show SMILES NC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-8(11(13)16)3-7-1-2-10-9(4-7)6-14-15-10/h1-4,6H,(H2,13,16)(H,14,15)/b8-3+
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n/an/a>1.50E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259823
PNG
(US9505766, 24)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1cn[nH]c1)\C#N
Show InChI InChI=1S/C13H10N4O/c14-6-11(13(15)18)5-9-1-3-10(4-2-9)12-7-16-17-8-12/h1-5,7-8H,(H2,15,18)(H,16,17)/b11-5+
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n/an/a>1.50E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259821
PNG
(US9505766, 22)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+
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n/an/a 1.50E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259815
PNG
(US9505766, 15)
Show SMILES NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N
Show InChI InChI=1S/C11H8N4O/c12-5-9(11(13)16)3-7-1-2-8-6-14-15-10(8)4-7/h1-4,6H,(H2,13,16)(H,14,15)/b9-3+
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n/an/a>1.50E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259827
PNG
(US9505766, 31)
Show SMILES CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+
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n/an/a>1.50E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259829
PNG
(US9505766, 33)
Show SMILES NC(=O)C(=C\c1nc2c(N)ncnc2n1CCCO)\C#N
Show InChI InChI=1S/C12H13N7O2/c13-5-7(11(15)21)4-8-18-9-10(14)16-6-17-12(9)19(8)2-1-3-20/h4,6,20H,1-3H2,(H2,15,21)(H2,14,16,17)/b7-4+
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n/an/a>1.50E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)


(Homo sapiens (Human))
BDBM259826
PNG
(US9505766, 30)
Show SMILES N#C\C=C\c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+
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n/an/a>3.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259827
PNG
(US9505766, 31)
Show SMILES CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+
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n/an/a 3.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259821
PNG
(US9505766, 22)
Show SMILES NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+
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n/an/a>3.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259827
PNG
(US9505766, 31)
Show SMILES CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Show InChI InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (T175A)


(Homo sapiens (Human))
BDBM259826
PNG
(US9505766, 30)
Show SMILES N#C\C=C\c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+
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n/an/a>3.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (C22A)


(Homo sapiens (Human))
BDBM259826
PNG
(US9505766, 30)
Show SMILES N#C\C=C\c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+
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n/an/a>3.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM259826
PNG
(US9505766, 30)
Show SMILES N#C\C=C\c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+
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n/an/a>3.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...


Citation and Details
More data for this
Ligand-Target Pair
Ribosomal S6 kinase 2 (RSK-2)(C436V)


(Homo sapiens (Human))
BDBM259826
PNG
(US9505766, 30)
Show SMILES N#C\C=C\c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+
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UniChem
US Patent
n/an/a>3.00E+5n/an/an/an/an/an/a



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...


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* indicates data uncertainty>20%