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Patent code US9512115

Compile Data Set for Download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259915
PNG
(US9512115, 19)
Show SMILES Fc1c(F)c(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C20H16F4N4O2/c21-17-12(2-4-15(18(17)22)27-6-5-20(23,24)9-27)16-8-30-19(29)28(16)11-1-3-13-14(7-11)26-10-25-13/h1-4,7,10,16H,5-6,8-9H2,(H,25,26)/t16-/m1/s1
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US Patent
2.49n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259915
PNG
(US9512115, 19)
Show SMILES Fc1c(F)c(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C20H16F4N4O2/c21-17-12(2-4-15(18(17)22)27-6-5-20(23,24)9-27)16-8-30-19(29)28(16)11-1-3-13-14(7-11)26-10-25-13/h1-4,7,10,16H,5-6,8-9H2,(H,25,26)/t16-/m1/s1
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2.53n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259914
PNG
(US9512115, 18)
Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C20H17F3N4O2/c21-15-7-12(26-6-5-20(22,23)10-26)1-3-14(15)18-9-29-19(28)27(18)13-2-4-16-17(8-13)25-11-24-16/h1-4,7-8,11,18H,5-6,9-10H2,(H,24,25)/t18-/m1/s1
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2.69n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259898
PNG
(US9512115, 1)
Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C20H17F4N3O3/c1-20(23,24)6-7-29-16-5-3-12(17(21)18(16)22)15-9-30-19(28)27(15)11-2-4-13-14(8-11)26-10-25-13/h2-5,8,10,15H,6-7,9H2,1H3,(H,25,26)/t15-/m1/s1
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2.90n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259914
PNG
(US9512115, 18)
Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C20H17F3N4O2/c21-15-7-12(26-6-5-20(22,23)10-26)1-3-14(15)18-9-29-19(28)27(18)13-2-4-16-17(8-13)25-11-24-16/h1-4,7-8,11,18H,5-6,9-10H2,(H,24,25)/t18-/m1/s1
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2.92n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259907
PNG
(US9512115, 11)
Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C19H15F4N3O3/c20-16(21)5-6-28-15-4-2-11(17(22)18(15)23)14-8-29-19(27)26(14)10-1-3-12-13(7-10)25-9-24-12/h1-4,7,9,14,16H,5-6,8H2,(H,24,25)/t14-/m1/s1
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3.34n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259898
PNG
(US9512115, 1)
Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C20H17F4N3O3/c1-20(23,24)6-7-29-16-5-3-12(17(21)18(16)22)15-9-30-19(28)27(15)11-2-4-13-14(8-11)26-10-25-13/h2-5,8,10,15H,6-7,9H2,1H3,(H,25,26)/t15-/m1/s1
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3.58n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259916
PNG
(US9512115, 20)
Show SMILES Fc1cc(cc(F)c1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C20H16F4N4O2/c21-13-5-12(27-4-3-20(23,24)9-27)6-14(22)18(13)17-8-30-19(29)28(17)11-1-2-15-16(7-11)26-10-25-15/h1-2,5-7,10,17H,3-4,8-9H2,(H,25,26)/t17-/m1/s1
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4.53n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259900
PNG
(US9512115, 3)
Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C20H18F3N3O3/c1-20(22,23)6-7-28-13-3-4-14(15(21)9-13)18-10-29-19(27)26(18)12-2-5-16-17(8-12)25-11-24-16/h2-5,8-9,11,18H,6-7,10H2,1H3,(H,24,25)/t18-/m1/s1
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5.02n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259900
PNG
(US9512115, 3)
Show SMILES CC(F)(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C20H18F3N3O3/c1-20(22,23)6-7-28-13-3-4-14(15(21)9-13)18-10-29-19(27)26(18)12-2-5-16-17(8-12)25-11-24-16/h2-5,8-9,11,18H,6-7,10H2,1H3,(H,24,25)/t18-/m1/s1
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5.03n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259919
PNG
(US9512115, 23)
Show SMILES FC1(F)CCN(C1)c1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(c1)C#N
Show InChI InChI=1S/C21H17F2N5O2/c22-21(23)5-6-27(11-21)14-1-3-16(13(7-14)9-24)19-10-30-20(29)28(19)15-2-4-17-18(8-15)26-12-25-17/h1-4,7-8,12,19H,5-6,10-11H2,(H,25,26)/t19-/m1/s1
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5.15n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259916
PNG
(US9512115, 20)
Show SMILES Fc1cc(cc(F)c1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)N1CCC(F)(F)C1
Show InChI InChI=1S/C20H16F4N4O2/c21-13-5-12(27-4-3-20(23,24)9-27)6-14(22)18(13)17-8-30-19(29)28(17)11-1-2-15-16(7-11)26-10-25-15/h1-2,5-7,10,17H,3-4,8-9H2,(H,25,26)/t17-/m1/s1
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5.29n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259907
PNG
(US9512115, 11)
Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C19H15F4N3O3/c20-16(21)5-6-28-15-4-2-11(17(22)18(15)23)14-8-29-19(27)26(14)10-1-3-12-13(7-10)25-9-24-12/h1-4,7,9,14,16H,5-6,8H2,(H,24,25)/t14-/m1/s1
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5.54n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259903
PNG
(US9512115, 6)
Show SMILES CC(F)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C19H15F4N3O3/c1-19(22,23)8-29-15-5-3-11(16(20)17(15)21)14-7-28-18(27)26(14)10-2-4-12-13(6-10)25-9-24-12/h2-6,9,14H,7-8H2,1H3,(H,24,25)/t14-/m1/s1
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6.21n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259899
PNG
(US9512115, 2)
Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C19H16F3N3O3/c20-14-8-12(27-6-5-18(21)22)2-3-13(14)17-9-28-19(26)25(17)11-1-4-15-16(7-11)24-10-23-15/h1-4,7-8,10,17-18H,5-6,9H2,(H,23,24)/t17-/m1/s1
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6.54n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259913
PNG
(US9512115, 17)
Show SMILES CC(F)(F)COc1cc(F)c([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C19H15F4N3O3/c1-19(22,23)8-29-11-5-12(20)17(13(21)6-11)16-7-28-18(27)26(16)10-2-3-14-15(4-10)25-9-24-14/h2-6,9,16H,7-8H2,1H3,(H,24,25)/t16-/m1/s1
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6.66n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259903
PNG
(US9512115, 6)
Show SMILES CC(F)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C19H15F4N3O3/c1-19(22,23)8-29-15-5-3-11(16(20)17(15)21)14-7-28-18(27)26(14)10-2-4-12-13(6-10)25-9-24-12/h2-6,9,14H,7-8H2,1H3,(H,24,25)/t14-/m1/s1
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6.71n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259919
PNG
(US9512115, 23)
Show SMILES FC1(F)CCN(C1)c1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(c1)C#N
Show InChI InChI=1S/C21H17F2N5O2/c22-21(23)5-6-27(11-21)14-1-3-16(13(7-14)9-24)19-10-30-20(29)28(19)15-2-4-17-18(8-15)26-12-25-17/h1-4,7-8,12,19H,5-6,10-11H2,(H,25,26)/t19-/m1/s1
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7.89n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259913
PNG
(US9512115, 17)
Show SMILES CC(F)(F)COc1cc(F)c([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C19H15F4N3O3/c1-19(22,23)8-29-11-5-12(20)17(13(21)6-11)16-7-28-18(27)26(16)10-2-3-14-15(4-10)25-9-24-14/h2-6,9,16H,7-8H2,1H3,(H,24,25)/t16-/m1/s1
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8.29n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259899
PNG
(US9512115, 2)
Show SMILES FC(F)CCOc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C19H16F3N3O3/c20-14-8-12(27-6-5-18(21)22)2-3-13(14)17-9-28-19(26)25(17)11-1-4-15-16(7-11)24-10-23-15/h1-4,7-8,10,17-18H,5-6,9H2,(H,23,24)/t17-/m1/s1
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8.5n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259906
PNG
(US9512115, 10)
Show SMILES CC(F)(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18F3N3O3/c1-20(22,23)6-7-28-18-5-2-12(8-14(18)21)17-10-29-19(27)26(17)13-3-4-15-16(9-13)25-11-24-15/h2-5,8-9,11,17H,6-7,10H2,1H3,(H,24,25)/t17-/m1/s1
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8.95n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259906
PNG
(US9512115, 10)
Show SMILES CC(F)(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18F3N3O3/c1-20(22,23)6-7-28-18-5-2-12(8-14(18)21)17-10-29-19(27)26(17)13-3-4-15-16(9-13)25-11-24-15/h2-5,8-9,11,17H,6-7,10H2,1H3,(H,24,25)/t17-/m1/s1
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8.99n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259921
PNG
(US9512115, 25)
Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)C1CCC(F)(F)CC1
Show InChI InChI=1S/C22H20F3N3O2/c23-17-9-14(13-5-7-22(24,25)8-6-13)1-3-16(17)20-11-30-21(29)28(20)15-2-4-18-19(10-15)27-12-26-18/h1-4,9-10,12-13,20H,5-8,11H2,(H,26,27)/t20-/m1/s1
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9.24n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259904
PNG
(US9512115, 7)
Show SMILES CC(C)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C20H19F2N3O3/c1-20(2,22)10-28-13-4-5-14(15(21)8-13)18-9-27-19(26)25(18)12-3-6-16-17(7-12)24-11-23-16/h3-8,11,18H,9-10H2,1-2H3,(H,23,24)/t18-/m1/s1
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9.83n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259917
PNG
(US9512115, 21)
Show SMILES Fc1cc(ccc1N1CCC(F)(F)C1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H17F3N4O2/c21-14-7-12(1-4-17(14)26-6-5-20(22,23)10-26)18-9-29-19(28)27(18)13-2-3-15-16(8-13)25-11-24-15/h1-4,7-8,11,18H,5-6,9-10H2,(H,24,25)/t18-/m1/s1
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10.4n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259904
PNG
(US9512115, 7)
Show SMILES CC(C)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C20H19F2N3O3/c1-20(2,22)10-28-13-4-5-14(15(21)8-13)18-9-27-19(26)25(18)12-3-6-16-17(7-12)24-11-23-16/h3-8,11,18H,9-10H2,1-2H3,(H,23,24)/t18-/m1/s1
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10.9n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259921
PNG
(US9512115, 25)
Show SMILES Fc1cc(ccc1[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1)C1CCC(F)(F)CC1
Show InChI InChI=1S/C22H20F3N3O2/c23-17-9-14(13-5-7-22(24,25)8-6-13)1-3-16(17)20-11-30-21(29)28(20)15-2-4-18-19(10-15)27-12-26-18/h1-4,9-10,12-13,20H,5-8,11H2,(H,26,27)/t20-/m1/s1
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11.3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259920
PNG
(US9512115, 24)
Show SMILES FC1(F)CCN(C1)c1ccc(cc1C#N)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H17F2N5O2/c22-21(23)5-6-27(11-21)18-4-1-13(7-14(18)9-24)19-10-30-20(29)28(19)15-2-3-16-17(8-15)26-12-25-16/h1-4,7-8,12,19H,5-6,10-11H2,(H,25,26)/t19-/m1/s1
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11.4n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259926
PNG
(US9512115, 30)
Show SMILES CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C20H18F3N3O2/c1-20(22,23)7-6-12-2-4-14(15(21)8-12)18-10-28-19(27)26(18)13-3-5-16-17(9-13)25-11-24-16/h2-5,8-9,11,18H,6-7,10H2,1H3,(H,24,25)/t18-/m1/s1
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12.0n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259926
PNG
(US9512115, 30)
Show SMILES CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1
Show InChI InChI=1S/C20H18F3N3O2/c1-20(22,23)7-6-12-2-4-14(15(21)8-12)18-10-28-19(27)26(18)13-3-5-16-17(9-13)25-11-24-16/h2-5,8-9,11,18H,6-7,10H2,1H3,(H,24,25)/t18-/m1/s1
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12.2n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259901
PNG
(US9512115, 4)
Show SMILES FC(F)CCOc1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H17F2N3O3/c20-18(21)7-8-26-14-4-1-12(2-5-14)17-10-27-19(25)24(17)13-3-6-15-16(9-13)23-11-22-15/h1-6,9,11,17-18H,7-8,10H2,(H,22,23)/t17-/m1/s1
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12.6n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259909
PNG
(US9512115, 13)
Show SMILES FC(F)CCOc1c(F)cc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H15F4N3O3/c20-12-5-10(6-13(21)18(12)28-4-3-17(22)23)16-8-29-19(27)26(16)11-1-2-14-15(7-11)25-9-24-14/h1-2,5-7,9,16-17H,3-4,8H2,(H,24,25)/t16-/m1/s1
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13.1n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259908
PNG
(US9512115, 12)
Show SMILES FC(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H16F3N3O3/c20-13-7-11(1-4-17(13)27-6-5-18(21)22)16-9-28-19(26)25(16)12-2-3-14-15(8-12)24-10-23-14/h1-4,7-8,10,16,18H,5-6,9H2,(H,23,24)/t16-/m1/s1
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13.1n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259922
PNG
(US9512115, 26)
Show SMILES Fc1cc(ccc1C1CCC(F)(F)CC1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H20F3N3O2/c23-17-9-14(1-3-16(17)13-5-7-22(24,25)8-6-13)20-11-30-21(29)28(20)15-2-4-18-19(10-15)27-12-26-18/h1-4,9-10,12-13,20H,5-8,11H2,(H,26,27)/t20-/m1/s1
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13.6n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259922
PNG
(US9512115, 26)
Show SMILES Fc1cc(ccc1C1CCC(F)(F)CC1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H20F3N3O2/c23-17-9-14(1-3-16(17)13-5-7-22(24,25)8-6-13)20-11-30-21(29)28(20)15-2-4-18-19(10-15)27-12-26-18/h1-4,9-10,12-13,20H,5-8,11H2,(H,26,27)/t20-/m1/s1
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14.3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259924
PNG
(US9512115, 28)
Show SMILES CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C20H17F4N3O2/c1-20(23,24)7-6-11-2-4-13(18(22)17(11)21)16-9-29-19(28)27(16)12-3-5-14-15(8-12)26-10-25-14/h2-5,8,10,16H,6-7,9H2,1H3,(H,25,26)/t16-/m1/s1
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14.9n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259918
PNG
(US9512115, 22)
Show SMILES FC1(F)CCN(C1)c1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18F2N4O2/c21-20(22)7-8-25(11-20)14-3-1-13(2-4-14)18-10-28-19(27)26(18)15-5-6-16-17(9-15)24-12-23-16/h1-6,9,12,18H,7-8,10-11H2,(H,23,24)/t18-/m1/s1
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15.1n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259923
PNG
(US9512115, 27)
Show SMILES FC1(F)CCC(CC1)c1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H21F2N3O2/c23-22(24)9-7-15(8-10-22)14-1-3-16(4-2-14)20-12-29-21(28)27(20)17-5-6-18-19(11-17)26-13-25-18/h1-6,11,13,15,20H,7-10,12H2,(H,25,26)/t20-/m1/s1
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15.4n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259908
PNG
(US9512115, 12)
Show SMILES FC(F)CCOc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H16F3N3O3/c20-13-7-11(1-4-17(13)27-6-5-18(21)22)16-9-28-19(26)25(16)12-2-3-14-15(8-12)24-10-23-14/h1-4,7-8,10,16,18H,5-6,9H2,(H,23,24)/t16-/m1/s1
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15.4n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259920
PNG
(US9512115, 24)
Show SMILES FC1(F)CCN(C1)c1ccc(cc1C#N)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H17F2N5O2/c22-21(23)5-6-27(11-21)18-4-1-13(7-14(18)9-24)19-10-30-20(29)28(19)15-2-3-16-17(8-15)26-12-25-16/h1-4,7-8,12,19H,5-6,10-11H2,(H,25,26)/t19-/m1/s1
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15.5n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259912
PNG
(US9512115, 16)
Show SMILES FC(F)CCCOc1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19F2N3O3/c21-19(22)2-1-9-27-15-6-3-13(4-7-15)18-11-28-20(26)25(18)14-5-8-16-17(10-14)24-12-23-16/h3-8,10,12,18-19H,1-2,9,11H2,(H,23,24)/t18-/m1/s1
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16.0n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259917
PNG
(US9512115, 21)
Show SMILES Fc1cc(ccc1N1CCC(F)(F)C1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H17F3N4O2/c21-14-7-12(1-4-17(14)26-6-5-20(22,23)10-26)18-9-29-19(28)27(18)13-2-3-15-16(8-13)25-11-24-15/h1-4,7-8,11,18H,5-6,9-10H2,(H,24,25)/t18-/m1/s1
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16.7n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259901
PNG
(US9512115, 4)
Show SMILES FC(F)CCOc1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H17F2N3O3/c20-18(21)7-8-26-14-4-1-12(2-5-14)17-10-27-19(25)24(17)13-3-6-15-16(9-13)23-11-22-15/h1-6,9,11,17-18H,7-8,10H2,(H,22,23)/t17-/m1/s1
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17.8n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259902
PNG
(US9512115, 5)
Show SMILES CC(F)(F)COc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H16F3N3O3/c1-19(21,22)9-28-17-5-2-11(6-13(17)20)16-8-27-18(26)25(16)12-3-4-14-15(7-12)24-10-23-14/h2-7,10,16H,8-9H2,1H3,(H,23,24)/t16-/m1/s1
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19.2n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259918
PNG
(US9512115, 22)
Show SMILES FC1(F)CCN(C1)c1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18F2N4O2/c21-20(22)7-8-25(11-20)14-3-1-13(2-4-14)18-10-28-19(27)26(18)15-5-6-16-17(9-15)24-12-23-16/h1-6,9,12,18H,7-8,10-11H2,(H,23,24)/t18-/m1/s1
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20.4n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259902
PNG
(US9512115, 5)
Show SMILES CC(F)(F)COc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H16F3N3O3/c1-19(21,22)9-28-17-5-2-11(6-13(17)20)16-8-27-18(26)25(16)12-3-4-14-15(7-12)24-10-23-14/h2-7,10,16H,8-9H2,1H3,(H,23,24)/t16-/m1/s1
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21.3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259912
PNG
(US9512115, 16)
Show SMILES FC(F)CCCOc1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19F2N3O3/c21-19(22)2-1-9-27-15-6-3-13(4-7-15)18-11-28-20(26)25(18)14-5-8-16-17(10-14)24-12-23-16/h3-8,10,12,18-19H,1-2,9,11H2,(H,23,24)/t18-/m1/s1
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22.1n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259910
PNG
(US9512115, 14)
Show SMILES CC(F)(F)COc1ccc(cc1C#N)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H16F2N4O3/c1-20(21,22)10-29-18-5-2-12(6-13(18)8-23)17-9-28-19(27)26(17)14-3-4-15-16(7-14)25-11-24-15/h2-7,11,17H,9-10H2,1H3,(H,24,25)/t17-/m1/s1
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22.5n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259911
PNG
(US9512115, 15)
Show SMILES CC(F)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(c1)C#N
Show InChI InChI=1S/C20H16F2N4O3/c1-20(21,22)10-29-14-3-4-15(12(6-14)8-23)18-9-28-19(27)26(18)13-2-5-16-17(7-13)25-11-24-16/h2-7,11,18H,9-10H2,1H3,(H,24,25)/t18-/m1/s1
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22.7n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259924
PNG
(US9512115, 28)
Show SMILES CC(F)(F)CCc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1F
Show InChI InChI=1S/C20H17F4N3O2/c1-20(23,24)7-6-11-2-4-13(18(22)17(11)21)16-9-29-19(28)27(16)12-3-5-14-15(8-12)26-10-25-14/h2-5,8,10,16H,6-7,9H2,1H3,(H,25,26)/t16-/m1/s1
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23.8n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259909
PNG
(US9512115, 13)
Show SMILES FC(F)CCOc1c(F)cc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H15F4N3O3/c20-12-5-10(6-13(21)18(12)28-4-3-17(22)23)16-8-29-19(27)26(16)11-1-2-14-15(7-11)25-9-24-14/h1-2,5-7,9,16-17H,3-4,8H2,(H,24,25)/t16-/m1/s1
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24.5n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259905
PNG
(US9512115, 8)
Show SMILES CC(F)(F)COc1c(F)cc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H15F4N3O3/c1-19(22,23)8-29-17-12(20)4-10(5-13(17)21)16-7-28-18(27)26(16)11-2-3-14-15(6-11)25-9-24-14/h2-6,9,16H,7-8H2,1H3,(H,24,25)/t16-/m1/s1
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26.0n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259925
PNG
(US9512115, 29)
Show SMILES CC(F)(F)CCc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18F3N3O2/c1-20(22,23)7-6-12-2-3-13(8-15(12)21)18-10-28-19(27)26(18)14-4-5-16-17(9-14)25-11-24-16/h2-5,8-9,11,18H,6-7,10H2,1H3,(H,24,25)/t18-/m1/s1
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29.1n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259925
PNG
(US9512115, 29)
Show SMILES CC(F)(F)CCc1ccc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18F3N3O2/c1-20(22,23)7-6-12-2-3-13(8-15(12)21)18-10-28-19(27)26(18)14-4-5-16-17(9-14)25-11-24-16/h2-5,8-9,11,18H,6-7,10H2,1H3,(H,24,25)/t18-/m1/s1
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29.7n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259905
PNG
(US9512115, 8)
Show SMILES CC(F)(F)COc1c(F)cc(cc1F)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C19H15F4N3O3/c1-19(22,23)8-29-17-12(20)4-10(5-13(17)21)16-7-28-18(27)26(16)11-2-3-14-15(6-11)25-9-24-14/h2-6,9,16H,7-8H2,1H3,(H,24,25)/t16-/m1/s1
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30.9n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259910
PNG
(US9512115, 14)
Show SMILES CC(F)(F)COc1ccc(cc1C#N)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H16F2N4O3/c1-20(21,22)10-29-18-5-2-12(6-13(18)8-23)17-9-28-19(27)26(17)14-3-4-15-16(7-14)25-11-24-15/h2-7,11,17H,9-10H2,1H3,(H,24,25)/t17-/m1/s1
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31.6n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259911
PNG
(US9512115, 15)
Show SMILES CC(F)(F)COc1ccc([C@H]2COC(=O)N2c2ccc3[nH]cnc3c2)c(c1)C#N
Show InChI InChI=1S/C20H16F2N4O3/c1-20(21,22)10-29-14-3-4-15(12(6-14)8-23)18-9-28-19(27)26(18)13-2-5-16-17(7-13)25-11-24-16/h2-7,11,18H,9-10H2,1H3,(H,24,25)/t18-/m1/s1
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36.4n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
Glutaminyl Cyclase


(Homo sapiens (human))
BDBM259923
PNG
(US9512115, 27)
Show SMILES FC1(F)CCC(CC1)c1ccc(cc1)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H21F2N3O2/c23-22(24)9-7-15(8-10-22)14-1-3-16(4-2-14)20-12-29-21(28)27(20)17-5-6-18-19(11-17)26-13-25-18/h1-6,11,13,15,20H,7-10,12H2,(H,25,26)/t20-/m1/s1
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44.3n/an/an/an/an/an/an/an/a



PROBIODRUG AG

US Patent


Assay Description
All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30° C. QC activity was evaluated fluorometr...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%