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Patent code US9518064

Compile Data Set for Download or QSAR
Found 131 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
par4 flipr assay


(Homo sapiens (Human))
BDBM286492
PNG
(2-Methoxy-6-(6-methoxy-4-((6-(4-methoxytetrahydro-...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)C3(CCOCC3)OC)cc(OC)cc2o1
Show InChI InChI=1S/C26H26N4O6S/c1-31-17-11-20(35-15-16-5-4-6-23(27-16)26(33-3)7-9-34-10-8-26)18-13-22(36-21(18)12-17)19-14-30-24(28-19)37-25(29-30)32-2/h4-6,11-14H,7-10,15H2,1-3H3
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n/an/a 0.230n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286477
PNG
(4-(6-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)-c3ccc(cc3)C(=O)N(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N5O5S/c1-33(2)27(35)18-10-8-17(9-11-18)22-7-5-6-19(30-22)16-38-24-12-20(36-3)13-25-21(24)14-26(39-25)23-15-34-28(31-23)40-29(32-34)37-4/h5-15H,16H2,1-4H3
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n/an/a 0.230n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286479
PNG
(US9518064, Example 98)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccc(cc3)C(=O)N(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C28H24N6O5S/c1-33(2)26(35)17-7-5-16(6-8-17)25-29-10-9-18(30-25)15-38-22-11-19(36-3)12-23-20(22)13-24(39-23)21-14-34-27(31-21)40-28(32-34)37-4/h5-14H,15H2,1-4H3
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n/an/a 0.290n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286495
PNG
((S)-2-(1-Fluoroethyl)-6-(4-((6-(4-fluorotetrahydro...)
Show SMILES COc1cc(OCc2cccc(n2)C2(F)CCOCC2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1S/C26H24F2N4O4S/c1-15(27)24-31-32-13-19(30-25(32)37-24)22-12-18-20(10-17(33-2)11-21(18)36-22)35-14-16-4-3-5-23(29-16)26(28)6-8-34-9-7-26/h3-5,10-13,15H,6-9,14H2,1-2H3/t15-/m0/s1
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n/an/a 0.310n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286494
PNG
(6-(4-((6-(4-Fluorotetrahydro-2H-pyran-4-yl)pyridin...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)C3(F)CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H23FN4O5S/c1-31-16-10-19(34-14-15-4-3-5-22(27-15)25(26)6-8-33-9-7-25)17-12-21(35-20(17)11-16)18-13-30-23(28-18)36-24(29-30)32-2/h3-5,10-13H,6-9,14H2,1-2H3
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n/an/a 0.350n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286493
PNG
((S)-2-(1-Fluoroethyl)-6-(6-methoxy-4-((6-(4-methox...)
Show SMILES COc1cc(OCc2cccc(n2)C2(CCOCC2)OC)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1S/C27H27FN4O5S/c1-16(28)25-31-32-14-20(30-26(32)38-25)23-13-19-21(11-18(33-2)12-22(19)37-23)36-15-17-5-4-6-24(29-17)27(34-3)7-9-35-10-8-27/h4-6,11-14,16H,7-10,15H2,1-3H3/t16-/m0/s1
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n/an/a 0.360n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286478
PNG
(6-(4-((2-(2-fluoropyridin-4-yl)pyrimidin-4-yl)meth...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccnc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C24H17FN6O4S/c1-32-15-8-18(34-12-14-4-6-27-22(28-14)13-3-5-26-21(25)7-13)16-10-20(35-19(16)9-15)17-11-31-23(29-17)36-24(30-31)33-2/h3-11H,12H2,1-2H3
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n/an/a 0.360n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286421
PNG
(US9518064, Example 37)
Show SMILES CCCOc1ncc(cn1)-c1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C28H25N5O5S/c1-4-8-36-26-29-13-19(14-30-26)18-7-5-6-17(9-18)16-37-23-10-20(34-2)11-24-21(23)12-25(38-24)22-15-33-27(31-22)39-28(32-33)35-3/h5-7,9-15H,4,8,16H2,1-3H3
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n/an/a 0.360n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286420
PNG
(US9518064, Example 36)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(Cl)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C26H19ClN4O4S/c1-32-18-9-22(34-14-15-4-3-5-16(8-15)20-7-6-17(27)12-28-20)19-11-24(35-23(19)10-18)21-13-31-25(29-21)36-26(30-31)33-2/h3-13H,14H2,1-2H3
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n/an/a 0.380n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286464
PNG
(6-(4-((3-Fluoro-5-(2-methoxypyrimidin-5-yl)benzyl)...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(F)cc(c3)-c3cnc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20FN5O5S/c1-33-18-7-21(36-13-14-4-15(6-17(27)5-14)16-10-28-24(34-2)29-11-16)19-9-23(37-22(19)8-18)20-12-32-25(30-20)38-26(31-32)35-3/h4-12H,13H2,1-3H3
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n/an/a 0.390n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286491
PNG
((S)-4-(6-(((2-(2-(1-Fluoroethyl)imidazo[2,1-b][1,3...)
Show SMILES COc1cc(OCc2cccc(n2)C2(O)CCOCC2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1S/C26H25FN4O5S/c1-15(27)24-30-31-13-19(29-25(31)37-24)22-12-18-20(10-17(33-2)11-21(18)36-22)35-14-16-4-3-5-23(28-16)26(32)6-8-34-9-7-26/h3-5,10-13,15,32H,6-9,14H2,1-2H3/t15-/m0/s1
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n/an/a 0.410n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286490
PNG
(4-(6-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)C3(O)CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C25H24N4O6S/c1-31-16-10-19(34-14-15-4-3-5-22(26-15)25(30)6-8-33-9-7-25)17-12-21(35-20(17)11-16)18-13-29-23(27-18)36-24(28-29)32-2/h3-5,10-13,30H,6-9,14H2,1-2H3
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n/an/a 0.450n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286424
PNG
(US9518064, Example 40)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S/c1-32-18-7-8-21(28-13-18)17-6-4-5-16(9-17)15-35-23-10-19(33-2)11-24-20(23)12-25(36-24)22-14-31-26(29-22)37-27(30-31)34-3/h4-14H,15H2,1-3H3
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n/an/a 0.470n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286418
PNG
(US9518064, Example 34)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S/c1-32-19-10-22(35-15-16-5-4-6-17(9-16)18-7-8-25(33-2)28-13-18)20-12-24(36-23(20)11-19)21-14-31-26(29-21)37-27(30-31)34-3/h4-14H,15H2,1-3H3
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n/an/a 0.480n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286419
PNG
(US9518064, Example 35)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H19N5O4S/c1-33-19-9-23(35-15-16-4-3-5-18(8-16)21-7-6-17(12-28)13-29-21)20-11-25(36-24(20)10-19)22-14-32-26(30-22)37-27(31-32)34-2/h3-11,13-14H,15H2,1-2H3
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n/an/a 0.490n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286453
PNG
(US9518064, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(OC)cc(c3)-c3cnc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O6S/c1-33-18-6-15(5-16(7-18)17-11-28-25(35-3)29-12-17)14-37-22-8-19(34-2)9-23-20(22)10-24(38-23)21-13-32-26(30-21)39-27(31-32)36-4/h5-13H,14H2,1-4H3
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n/an/a 0.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286423
PNG
(US9518064, Example 39)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(C)nc3F)cc(OC)cc2o1
Show InChI InChI=1S/C27H21FN4O4S/c1-15-7-8-19(25(28)29-15)17-6-4-5-16(9-17)14-35-22-10-18(33-2)11-23-20(22)12-24(36-23)21-13-32-26(30-21)37-27(31-32)34-3/h4-13H,14H2,1-3H3
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n/an/a 0.530n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286467
PNG
(2-Methoxy-6-(6-methoxy-4-((3-(5-(1-((tetrahydro-2H...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(C)OC3CCCCO3)cc(OC)cc2o1
Show InChI InChI=1S/C33H32N4O6S/c1-20(42-31-9-4-5-12-40-31)23-10-11-26(34-17-23)22-8-6-7-21(13-22)19-41-28-14-24(38-2)15-29-25(28)16-30(43-29)27-18-37-32(35-27)44-33(36-37)39-3/h6-8,10-11,13-18,20,31H,4-5,9,12,19H2,1-3H3
UniProtKB/SwissProt

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n/an/a 0.560n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286436
PNG
(US9518064, Example 52)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ncc(Cl)cc3C)cc(OC)cc2o1
Show InChI InChI=1S/C27H21ClN4O4S/c1-15-7-18(28)12-29-25(15)17-6-4-5-16(8-17)14-35-22-9-19(33-2)10-23-20(22)11-24(36-23)21-13-32-26(30-21)37-27(31-32)34-3/h4-13H,14H2,1-3H3
UniProtKB/SwissProt

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n/an/a 0.560n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286416
PNG
(US9518064, Example 32)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(F)c(C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21FN4O4S/c1-15-20(28)7-8-21(29-15)17-6-4-5-16(9-17)14-35-23-10-18(33-2)11-24-19(23)12-25(36-24)22-13-32-26(30-22)37-27(31-32)34-3/h4-13H,14H2,1-3H3
UniProtKB/SwissProt

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UniChem
n/an/a 0.570n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286449
PNG
(6-(4-((3-(6-Chloropyridin-3-yl)-5-methoxybenzyl)ox...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(OC)cc(c3)-c3ccc(Cl)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21ClN4O5S/c1-33-18-7-15(6-17(8-18)16-4-5-25(28)29-12-16)14-36-22-9-19(34-2)10-23-20(22)11-24(37-23)21-13-32-26(30-21)38-27(31-32)35-3/h4-13H,14H2,1-3H3
UniProtKB/SwissProt

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UniChem
n/an/a 0.570n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286427
PNG
(US9518064, Example 43)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C27H19F3N4O4S/c1-35-18-9-22(19-11-24(38-23(19)10-18)21-13-34-25(32-21)39-26(33-34)36-2)37-14-15-4-3-5-16(8-15)20-7-6-17(12-31-20)27(28,29)30/h3-13H,14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286417
PNG
(US9518064, Example 33)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ncc(F)cc3F)cc(OC)cc2o1
Show InChI InChI=1S/C26H18F2N4O4S/c1-33-17-8-21(35-13-14-4-3-5-15(6-14)24-19(28)7-16(27)11-29-24)18-10-23(36-22(18)9-17)20-12-32-25(30-20)37-26(31-32)34-2/h3-12H,13H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286422
PNG
(US9518064, Example 38)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(F)c(C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21FN4O4S/c1-15-7-18(12-29-25(15)28)17-6-4-5-16(8-17)14-35-22-9-19(33-2)10-23-20(22)11-24(36-23)21-13-32-26(30-21)37-27(31-32)34-3/h4-13H,14H2,1-3H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286431
PNG
(US9518064, Example 47)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H21N5O5S/c1-32-18-8-21(35-14-15-5-4-6-16(7-15)17-11-27-24(33-2)28-12-17)19-10-23(36-22(19)9-18)20-13-31-25(29-20)37-26(30-31)34-3/h4-13H,14H2,1-3H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286476
PNG
(US9518064, Example 95)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C3CCCCC3)cc(OC)cc2o1
Show InChI InChI=1S/C27H27N3O4S/c1-31-20-12-23(33-16-17-7-6-10-19(11-17)18-8-4-3-5-9-18)21-14-25(34-24(21)13-20)22-15-30-26(28-22)35-27(29-30)32-2/h6-7,10-15,18H,3-5,8-9,16H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286439
PNG
(US9518064, Example 55)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccnc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C26H19FN4O4S/c1-32-18-10-21(34-14-15-4-3-5-16(8-15)17-6-7-28-24(27)9-17)19-12-23(35-22(19)11-18)20-13-31-25(29-20)36-26(30-31)33-2/h3-13H,14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286474
PNG
(US9518064, Example 93)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C3=CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C26H23N3O5S/c1-30-19-11-22(33-15-16-4-3-5-18(10-16)17-6-8-32-9-7-17)20-13-24(34-23(20)12-19)21-14-29-25(27-21)35-26(28-29)31-2/h3-6,10-14H,7-9,15H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286473
PNG
(2-Methoxy-6-(6-methoxy-4-((3-(tetrahydro-2H-pyran-...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C26H25N3O5S/c1-30-19-11-22(33-15-16-4-3-5-18(10-16)17-6-8-32-9-7-17)20-13-24(34-23(20)12-19)21-14-29-25(27-21)35-26(28-29)31-2/h3-5,10-14,17H,6-9,15H2,1-2H3
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n/an/a 0.720n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286483
PNG
(US9518064, Example 102)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3csc(C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C23H18N6O4S2/c1-12-25-17(11-34-12)21-24-5-4-13(26-21)10-32-18-6-14(30-2)7-19-15(18)8-20(33-19)16-9-29-22(27-16)35-23(28-29)31-3/h4-9,11H,10H2,1-3H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286440
PNG
(US9518064, Example 56)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(Cl)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H19ClN4O4S/c1-32-18-9-21(34-14-15-4-3-5-16(8-15)17-6-7-24(27)28-12-17)19-11-23(35-22(19)10-18)20-13-31-25(29-20)36-26(30-31)33-2/h3-13H,14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286481
PNG
(US9518064, Example 100)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H21N5O5S/c1-32-17-6-4-15(5-7-17)24-27-9-8-16(28-24)14-35-21-10-18(33-2)11-22-19(21)12-23(36-22)20-13-31-25(29-20)37-26(30-31)34-3/h4-13H,14H2,1-3H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286470
PNG
(US9518064, Example 89)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(OC4CCCCO4)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C31H28N4O6S/c1-36-22-13-26(23-15-28(41-27(23)14-22)25-17-35-30(33-25)42-31(34-35)37-2)39-18-19-6-5-7-20(12-19)24-10-9-21(16-32-24)40-29-8-3-4-11-38-29/h5-7,9-10,12-17,29H,3-4,8,11,18H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286446
PNG
(6-(4-((3-Fluoro-5-(5-methoxypyridin-2-yl)benzyl)ox...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(F)cc(c3)-c3ccc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21FN4O5S/c1-33-18-4-5-21(29-12-18)16-6-15(7-17(28)8-16)14-36-23-9-19(34-2)10-24-20(23)11-25(37-24)22-13-32-26(30-22)38-27(31-32)35-3/h4-13H,14H2,1-3H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286485
PNG
(US9518064, Example 104)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)C3COc4ccccc4O3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N5O6S/c1-33-16-9-21(17-11-23(38-22(17)10-16)18-12-32-26(30-18)39-27(31-32)34-2)35-13-15-7-8-28-25(29-15)24-14-36-19-5-3-4-6-20(19)37-24/h3-12,24H,13-14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286482
PNG
(2-Methoxy-6-(6-methoxy-4-((2-phenylpyrimidin-4-yl)...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O4S/c1-31-17-10-20(33-14-16-8-9-26-23(27-16)15-6-4-3-5-7-15)18-12-22(34-21(18)11-17)19-13-30-24(28-19)35-25(29-30)32-2/h3-13H,14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286460
PNG
(US9518064, Example 78)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)-c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S/c1-32-18-9-7-16(8-10-18)21-6-4-5-17(28-21)15-35-23-11-19(33-2)12-24-20(23)13-25(36-24)22-14-31-26(29-22)37-27(30-31)34-3/h4-14H,15H2,1-3H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286445
PNG
(US9518064, Example 61)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(C)OCc3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C36H32N4O6S/c1-22(44-20-23-8-11-27(41-2)12-9-23)26-10-13-30(37-18-26)25-7-5-6-24(14-25)21-45-32-15-28(42-3)16-33-29(32)17-34(46-33)31-19-40-35(38-31)47-36(39-40)43-4/h5-19,22H,20-21H2,1-4H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286432
PNG
(US9518064, Example 48)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnsc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O4S2/c1-29-17-7-20(31-12-14-4-3-5-15(6-14)16-10-25-33-13-16)18-9-22(32-21(18)8-17)19-11-28-23(26-19)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286429
PNG
(US9518064, Example 45)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccnc3F)cc(OC)cc2o1
Show InChI InChI=1S/C26H19FN4O4S/c1-32-17-10-21(34-14-15-5-3-6-16(9-15)18-7-4-8-28-24(18)27)19-12-23(35-22(19)11-17)20-13-31-25(29-20)36-26(30-31)33-2/h3-13H,14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286426
PNG
(US9518064, Example 42)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(cn3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H18N6O4S/c1-33-18-7-22(35-14-15-4-3-5-16(6-15)20-12-28-17(10-27)11-29-20)19-9-24(36-23(19)8-18)21-13-32-25(30-21)37-26(31-32)34-2/h3-9,11-13H,14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286486
PNG
(US9518064, Example 105)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)C3(CC3)c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C28H23N5O4S/c1-34-19-12-22(20-14-24(37-23(20)13-19)21-15-33-26(31-21)38-27(32-33)35-2)36-16-18-8-11-29-25(30-18)28(9-10-28)17-6-4-3-5-7-17/h3-8,11-15H,9-10,16H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286387
PNG
(2-Methoxy-6-(6-methoxy-4-((3-(pyrimidin-5-yl)benzy...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cncnc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O4S/c1-31-18-7-21(33-13-15-4-3-5-16(6-15)17-10-26-14-27-11-17)19-9-23(34-22(19)8-18)20-12-30-24(28-20)35-25(29-30)32-2/h3-12,14H,13H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286448
PNG
(6-(4-((5-(Furan-3-yl)pyridin-3-yl)methoxy)-6-metho...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cncc(c3)-c3ccoc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O5S/c1-29-17-6-20(32-12-14-5-16(10-25-9-14)15-3-4-31-13-15)18-8-22(33-21(18)7-17)19-11-28-23(26-19)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
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n/an/a 1.08n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286488
PNG
(6-(6-Chloro-4-((3-(2-methoxypyrimidin-5-yl)benzyl)...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(OC)nc3)cc(Cl)cc2o1
Show InChI InChI=1S/C25H18ClN5O4S/c1-32-23-27-10-16(11-28-23)15-5-3-4-14(6-15)13-34-20-7-17(26)8-21-18(20)9-22(35-21)19-12-31-24(29-19)36-25(30-31)33-2/h3-12H,13H2,1-2H3
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n/an/a 1.09n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286469
PNG
(US9518064, Example 88)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(OC4CCCCO4)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C32H29N3O6S/c1-36-24-15-27(25-17-29(41-28(25)16-24)26-18-35-31(33-26)42-32(34-35)37-2)39-19-20-6-5-7-22(14-20)21-9-11-23(12-10-21)40-30-8-3-4-13-38-30/h5-7,9-12,14-18,30H,3-4,8,13,19H2,1-2H3
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286468
PNG
(1-(6-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cn3)C(C)O)cc(OC)cc2o1
Show InChI InChI=1S/C28H24N4O5S/c1-16(33)19-7-8-22(29-13-19)18-6-4-5-17(9-18)15-36-24-10-20(34-2)11-25-21(24)12-26(37-25)23-14-32-27(30-23)38-28(31-32)35-3/h4-14,16,33H,15H2,1-3H3
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n/an/a 1.11n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286435
PNG
(US9518064, Example 51)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(OC)cc3C)cc(OC)cc2o1
Show InChI InChI=1S/C28H24N4O5S/c1-16-8-26(34-3)29-13-21(16)18-7-5-6-17(9-18)15-36-23-10-19(33-2)11-24-20(23)12-25(37-24)22-14-32-27(30-22)38-28(31-32)35-4/h5-14H,15H2,1-4H3
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n/an/a 1.19n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286428
PNG
(US9518064, Example 44)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ncccc3F)cc(OC)cc2o1
Show InChI InChI=1S/C26H19FN4O4S/c1-32-17-10-21(34-14-15-5-3-6-16(9-15)24-19(27)7-4-8-28-24)18-12-23(35-22(18)11-17)20-13-31-25(29-20)36-26(30-31)33-2/h3-13H,14H2,1-2H3
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n/an/a 1.21n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286442
PNG
(US9518064, Example 58)
Show SMILES COCOc1cnc(cn1)-c1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C27H23N5O6S/c1-33-15-37-25-12-28-20(11-29-25)17-6-4-5-16(7-17)14-36-22-8-18(34-2)9-23-19(22)10-24(38-23)21-13-32-26(30-21)39-27(31-32)35-3/h4-13H,14-15H2,1-3H3
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n/an/a 1.22n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286397
PNG
(US9518064, Example 9)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccsc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N3O4S2/c1-29-18-9-21(31-13-15-4-3-5-16(8-15)17-6-7-33-14-17)19-11-23(32-22(19)10-18)20-12-28-24(26-20)34-25(27-28)30-2/h3-12,14H,13H2,1-2H3
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n/an/a 1.26n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286395
PNG
(US9518064, Example 7)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(F)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H19FN4O4S/c1-32-18-9-21(34-14-15-4-3-5-16(8-15)17-6-7-24(27)28-12-17)19-11-23(35-22(19)10-18)20-13-31-25(29-20)36-26(30-31)33-2/h3-13H,14H2,1-2H3
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n/an/a 1.29n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286463
PNG
(2-(6-Methoxy-4-((3-(2-methoxypyrimidin-5-yl)benzyl...)
Show SMILES COc1cc(OCc2cccc(c2)-c2cnc(OC)nc2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Show InChI InChI=1S/C28H23N5O4/c1-17-7-8-27-31-23(15-33(27)32-17)26-12-22-24(10-21(34-2)11-25(22)37-26)36-16-18-5-4-6-19(9-18)20-13-29-28(35-3)30-14-20/h4-15H,16H2,1-3H3
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n/an/a 1.32n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286484
PNG
(US9518064, Example 103)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)C3CC3)cc(OC)cc2o1
Show InChI InChI=1S/C22H19N5O4S/c1-28-14-7-17(30-11-13-5-6-23-20(24-13)12-3-4-12)15-9-19(31-18(15)8-14)16-10-27-21(25-16)32-22(26-27)29-2/h5-10,12H,3-4,11H2,1-2H3
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n/an/a 1.39n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286489
PNG
(6-(6-Chloro-4-((3-(5-methoxypyrazin-2-yl)benzyl)ox...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(OC)cn3)cc(Cl)cc2o1
Show InChI InChI=1S/C25H18ClN5O4S/c1-32-23-11-27-18(10-28-23)15-5-3-4-14(6-15)13-34-20-7-16(26)8-21-17(20)9-22(35-21)19-12-31-24(29-19)36-25(30-31)33-2/h3-12H,13H2,1-2H3
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n/an/a 1.43n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286438
PNG
(US9518064, Example 54)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ncc(Cl)cc3Cl)cc(OC)cc2o1
Show InChI InChI=1S/C26H18Cl2N4O4S/c1-33-17-8-21(35-13-14-4-3-5-15(6-14)24-19(28)7-16(27)11-29-24)18-10-23(36-22(18)9-17)20-12-32-25(30-20)37-26(31-32)34-2/h3-12H,13H2,1-2H3
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n/an/a 1.47n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286437
PNG
(US9518064, Example 53)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C26H21N5O5S/c1-32-17-8-21(35-14-15-5-4-6-16(7-15)19-11-28-24(33-2)12-27-19)18-10-23(36-22(18)9-17)20-13-31-25(29-20)37-26(30-31)34-3/h4-13H,14H2,1-3H3
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n/an/a 1.48n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286452
PNG
(US9518064, Example 70)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(F)cc(c3)-c3ncc(F)cc3F)cc(OC)cc2o1
Show InChI InChI=1S/C26H17F3N4O4S/c1-34-17-7-21(36-12-13-3-14(5-15(27)4-13)24-19(29)6-16(28)10-30-24)18-9-23(37-22(18)8-17)20-11-33-25(31-20)38-26(32-33)35-2/h3-11H,12H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286466
PNG
(5-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COCCN(C)C(=O)c1ccc(cn1)-c1cccc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)c1
Show InChI InChI=1S/C31H29N5O6S/c1-35(10-11-38-2)29(37)24-9-8-21(16-32-24)20-7-5-6-19(12-20)18-41-26-13-22(39-3)14-27-23(26)15-28(42-27)25-17-36-30(33-25)43-31(34-36)40-4/h5-9,12-17H,10-11,18H2,1-4H3
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n/an/a 1.49n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286404
PNG
(US9518064, Example 14)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(F)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C26H19FN4O4S/c1-32-18-9-22(34-14-15-4-3-5-16(8-15)20-7-6-17(27)12-28-20)19-11-24(35-23(19)10-18)21-13-31-25(29-21)36-26(30-31)33-2/h3-13H,14H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286456
PNG
(US9518064, Example 74)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cncc(c3)-c3ccc(Cl)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H18ClN5O4S/c1-32-17-6-20(34-13-14-5-16(10-27-9-14)15-3-4-23(26)28-11-15)18-8-22(35-21(18)7-17)19-12-31-24(29-19)36-25(30-31)33-2/h3-12H,13H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286487
PNG
((2-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3nc(CO)c(C)s3)cc(OC)cc2o1
Show InChI InChI=1S/C26H22N4O5S2/c1-14-20(12-31)27-24(36-14)16-6-4-5-15(7-16)13-34-21-8-17(32-2)9-22-18(21)10-23(35-22)19-11-30-25(28-19)37-26(29-30)33-3/h4-11,31H,12-13H2,1-3H3
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n/an/a 1.59n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286430
PNG
(US9518064, Example 46)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ncccc3C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H19N5O4S/c1-33-19-10-22(35-15-16-5-3-6-17(9-16)25-18(13-28)7-4-8-29-25)20-12-24(36-23(20)11-19)21-14-32-26(30-21)37-27(31-32)34-2/h3-12,14H,15H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286441
PNG
(US9518064, Example 57)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)C(=O)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C31H27N5O6S/c1-38-22-13-26(23-15-28(42-27(23)14-22)25-17-36-30(33-25)43-31(34-36)39-2)41-18-19-4-3-5-20(12-19)21-6-7-24(32-16-21)29(37)35-8-10-40-11-9-35/h3-7,12-17H,8-11,18H2,1-2H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286479
PNG
(US9518064, Example 98)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccc(cc3)C(=O)N(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C28H24N6O5S/c1-33(2)26(35)17-7-5-16(6-8-17)25-29-10-9-18(30-25)15-38-22-11-19(36-3)12-23-20(22)13-24(39-23)21-14-34-27(31-21)40-28(32-34)37-4/h5-14H,15H2,1-4H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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n/an/a 1.67n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286396
PNG
(US9518064, Example 8)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(OC)cc3C)cc(OC)cc2o1
Show InChI InChI=1S/C29H25N3O5S/c1-17-10-20(33-2)8-9-22(17)19-7-5-6-18(11-19)16-36-25-12-21(34-3)13-26-23(25)14-27(37-26)24-15-32-28(30-24)38-29(31-32)35-4/h5-15H,16H2,1-4H3
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n/an/a 1.69n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286403
PNG
(US9518064, Example 13)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H19N5O4S/c1-33-20-9-23(35-15-16-4-3-5-17(8-16)18-6-7-19(12-28)29-13-18)21-11-25(36-24(21)10-20)22-14-32-26(30-22)37-27(31-32)34-2/h3-11,13-14H,15H2,1-2H3
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n/an/a 1.74n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286481
PNG
(US9518064, Example 100)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H21N5O5S/c1-32-17-6-4-15(5-7-17)24-27-9-8-16(28-24)14-35-21-10-18(33-2)11-22-19(21)12-23(36-22)20-13-31-25(29-20)37-26(30-31)34-3/h4-13H,14H2,1-3H3
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n/an/a 1.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286394
PNG
(US9518064, Example 6)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccoc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N3O5S/c1-29-18-9-21(32-13-15-4-3-5-16(8-15)17-6-7-31-14-17)19-11-23(33-22(19)10-18)20-12-28-24(26-20)34-25(27-28)30-2/h3-12,14H,13H2,1-2H3
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n/an/a 1.86n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286434
PNG
(US9518064, Example 50)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ncc(Cl)cc3F)cc(OC)cc2o1
Show InChI InChI=1S/C26H18ClFN4O4S/c1-33-17-8-21(35-13-14-4-3-5-15(6-14)24-19(28)7-16(27)11-29-24)18-10-23(36-22(18)9-17)20-12-32-25(30-20)37-26(31-32)34-2/h3-12H,13H2,1-2H3
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n/an/a 1.88n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286433
PNG
(US9518064, Example 49)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)N(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C28H25N5O4S/c1-32(2)26-9-8-19(14-29-26)18-7-5-6-17(10-18)16-36-23-11-20(34-3)12-24-21(23)13-25(37-24)22-15-33-27(30-22)38-28(31-33)35-4/h5-15H,16H2,1-4H3
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n/an/a 2.02n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286414
PNG
(US9518064, Example 25)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(C)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O4S/c1-16-7-8-21(28-13-16)18-6-4-5-17(9-18)15-34-23-10-19(32-2)11-24-20(23)12-25(35-24)22-14-31-26(29-22)36-27(30-31)33-3/h4-14H,15H2,1-3H3
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n/an/a 2.04n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286457
PNG
(US9518064, Example 75)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cncc(c3)-c3cnc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N6O5S/c1-32-17-5-20(35-13-14-4-15(9-26-8-14)16-10-27-23(33-2)28-11-16)18-7-22(36-21(18)6-17)19-12-31-24(29-19)37-25(30-31)34-3/h4-12H,13H2,1-3H3
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n/an/a 2.14n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286459
PNG
(US9518064, Example 77)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)-c3cnc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N6O5S/c1-32-16-7-20(35-13-15-5-4-6-18(28-15)14-10-26-23(33-2)27-11-14)17-9-22(36-21(17)8-16)19-12-31-24(29-19)37-25(30-31)34-3/h4-12H,13H2,1-3H3
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n/an/a 2.18n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286455
PNG
(US9518064, Example 73)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cncc(c3)-c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S/c1-32-19-6-4-17(5-7-19)18-8-16(12-28-13-18)15-35-23-9-20(33-2)10-24-21(23)11-25(36-24)22-14-31-26(29-22)37-27(30-31)34-3/h4-14H,15H2,1-3H3
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n/an/a 2.18n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286475
PNG
(US9518064, Example 94)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C3=CCCCC3)cc(OC)cc2o1
Show InChI InChI=1S/C27H25N3O4S/c1-31-20-12-23(33-16-17-7-6-10-19(11-17)18-8-4-3-5-9-18)21-14-25(34-24(21)13-20)22-15-30-26(28-22)35-27(29-30)32-2/h6-8,10-15H,3-5,9,16H2,1-2H3
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n/an/a 2.21n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286393
PNG
(US9518064, Example 5)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3c(C)noc3C)cc(OC)cc2o1
Show InChI InChI=1S/C26H22N4O5S/c1-14-24(15(2)35-29-14)17-7-5-6-16(8-17)13-33-21-9-18(31-3)10-22-19(21)11-23(34-22)20-12-30-25(27-20)36-26(28-30)32-4/h5-12H,13H2,1-4H3
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n/an/a 2.36n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286409
PNG
(US9518064, Example 19)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(OC)nc3OC)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O6S/c1-33-17-9-21(18-11-23(38-22(18)10-17)20-13-32-26(29-20)39-27(31-32)36-4)37-14-15-6-5-7-16(8-15)19-12-28-25(35-3)30-24(19)34-2/h5-13H,14H2,1-4H3
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n/an/a 2.42n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286424
PNG
(US9518064, Example 40)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S/c1-32-18-7-8-21(28-13-18)17-6-4-5-16(9-17)15-35-23-10-19(33-2)11-24-20(23)12-25(36-24)22-14-31-26(29-22)37-27(30-31)34-3/h4-14H,15H2,1-3H3
PDB

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n/an/a 2.86n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286478
PNG
(6-(4-((2-(2-fluoropyridin-4-yl)pyrimidin-4-yl)meth...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3ccnc(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C24H17FN6O4S/c1-32-15-8-18(34-12-14-4-6-27-22(28-14)13-3-5-26-21(25)7-13)16-10-20(35-19(16)9-15)17-11-31-23(29-17)36-24(30-31)33-2/h3-11H,12H2,1-2H3
PDB

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n/an/a 2.97n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286390
PNG
(2-Methoxy-6-(6-methoxy-4-((3-(pyrimidin-2-yl)benzy...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ncccn3)cc(OC)cc2o1
Show InChI InChI=1S/C25H19N5O4S/c1-31-17-10-20(33-14-15-5-3-6-16(9-15)23-26-7-4-8-27-23)18-12-22(34-21(18)11-17)19-13-30-24(28-19)35-25(29-30)32-2/h3-13H,14H2,1-2H3
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n/an/a 3.08n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286451
PNG
(US9518064, Example 68)
Show SMILES COc1cc(OCc2cccc(c2)-c2ccc(F)nc2)c2cc(oc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C27H19F3N4O3S/c1-27(29,30)25-33-34-13-20(32-26(34)38-25)23-11-19-21(9-18(35-2)10-22(19)37-23)36-14-15-4-3-5-16(8-15)17-6-7-24(28)31-12-17/h3-13H,14H2,1-2H3
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n/an/a 3.37n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286408
PNG
(US9518064, Example 18)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21N3O6S/c1-32-19-10-23(20-12-25(37-24(20)11-19)21-13-31-27(29-21)38-28(30-31)33-2)34-14-16-4-3-5-17(8-16)18-6-7-22-26(9-18)36-15-35-22/h3-13H,14-15H2,1-2H3
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n/an/a 3.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286398
PNG
(US9518064, Example 10)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnn(C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C25H21N5O4S/c1-29-12-17(11-26-29)16-6-4-5-15(7-16)14-33-21-8-18(31-2)9-22-19(21)10-23(34-22)20-13-30-24(27-20)35-25(28-30)32-3/h4-13H,14H2,1-3H3
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n/an/a 3.55n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286453
PNG
(US9518064, Example 71)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cc(OC)cc(c3)-c3cnc(OC)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H23N5O6S/c1-33-18-6-15(5-16(7-18)17-11-28-25(35-3)29-12-17)14-37-22-8-19(34-2)9-23-20(22)10-24(38-23)21-13-32-26(30-21)39-27(31-32)36-4/h5-13H,14H2,1-4H3
PDB

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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286437
PNG
(US9518064, Example 53)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc(OC)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C26H21N5O5S/c1-32-17-8-21(35-14-15-5-4-6-16(7-15)19-11-28-24(33-2)12-27-19)18-10-23(36-22(18)9-17)20-13-31-25(29-20)37-26(30-31)34-3/h4-13H,14H2,1-3H3
PDB

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n/an/a 3.63n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286401
PNG
(US9518064, Example 11)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3csc(C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N4O4S2/c1-14-26-20(13-34-14)16-6-4-5-15(7-16)12-32-21-8-17(30-2)9-22-18(21)10-23(33-22)19-11-29-24(27-19)35-25(28-29)31-3/h4-11,13H,12H2,1-3H3
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n/an/a 3.66n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286402
PNG
(US9518064, Example 12)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3csc4ccccc34)cc(OC)cc2o1
Show InChI InChI=1S/C29H21N3O4S2/c1-33-19-11-24(21-13-26(36-25(21)12-19)23-14-32-28(30-23)38-29(31-32)34-2)35-15-17-6-5-7-18(10-17)22-16-37-27-9-4-3-8-20(22)27/h3-14,16H,15H2,1-2H3
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n/an/a 3.76n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286407
PNG
(US9518064, Example 17)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(F)cc3F)cc(OC)cc2o1
Show InChI InChI=1S/C27H19F2N3O4S/c1-33-18-10-23(35-14-15-4-3-5-16(8-15)19-7-6-17(28)9-21(19)29)20-12-25(36-24(20)11-18)22-13-32-26(30-22)37-27(31-32)34-2/h3-13H,14H2,1-2H3
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n/an/a 3.78n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286447
PNG
(2-(1,1-Difluoroethyl)-6-(6-methoxy-4-((3-(pyrimidi...)
Show SMILES COc1cc(OCc2cccc(c2)-c2cncnc2)c2cc(oc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C26H19F2N5O3S/c1-26(27,28)24-32-33-12-20(31-25(33)37-24)23-9-19-21(7-18(34-2)8-22(19)36-23)35-13-15-4-3-5-16(6-15)17-10-29-14-30-11-17/h3-12,14H,13H2,1-2H3
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n/an/a 4.04n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286444
PNG
(US9518064, Example 60)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)C(=O)OC(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C31H28N4O6S/c1-31(2,3)41-28(36)23-10-9-20(15-32-23)19-8-6-7-18(11-19)17-39-25-12-21(37-4)13-26-22(25)14-27(40-26)24-16-35-29(33-24)42-30(34-35)38-5/h6-16H,17H2,1-5H3
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n/an/a 4.18n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286415
PNG
(US9518064, Example 27)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccnc(C)c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O4S/c1-16-9-19(7-8-28-16)18-6-4-5-17(10-18)15-34-23-11-20(32-2)12-24-21(23)13-25(35-24)22-14-31-26(29-22)36-27(30-31)33-3/h4-14H,15H2,1-3H3
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n/an/a 4.29n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286389
PNG
(2-Methoxy-6-(6-methoxy-4-((3′-(trifluorometh...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N3O4S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-34-26(32-22)39-27(33-34)36-2)37-15-16-5-3-6-17(9-16)18-7-4-8-19(10-18)28(29,30)31/h3-14H,15H2,1-2H3
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n/an/a 4.35n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286450
PNG
(US9518064, Example 67)
Show SMILES COc1cc(OCc2cccc(c2)-c2ccc(F)cn2)c2cc(oc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C27H19F3N4O3S/c1-27(29,30)25-33-34-13-21(32-26(34)38-25)24-11-19-22(9-18(35-2)10-23(19)37-24)36-14-15-4-3-5-16(8-15)20-7-6-17(28)12-31-20/h3-13H,14H2,1-2H3
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n/an/a 4.54n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286443
PNG
(US9518064, Example 59)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N5O5S/c1-36-22-13-25(23-15-27(40-26(23)14-22)24-17-35-29(32-24)41-30(33-35)37-2)39-18-19-4-3-5-20(12-19)21-6-7-28(31-16-21)34-8-10-38-11-9-34/h3-7,12-17H,8-11,18H2,1-2H3
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n/an/a 4.81n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286471
PNG
(US9518064, Example 90)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(O)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21N3O5S/c1-32-20-11-23(34-15-16-4-3-5-18(10-16)17-6-8-19(31)9-7-17)21-13-25(35-24(21)12-20)22-14-30-26(28-22)36-27(29-30)33-2/h3-14,31H,15H2,1-2H3
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n/an/a 4.91n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286403
PNG
(US9518064, Example 13)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H19N5O4S/c1-33-20-9-23(35-15-16-4-3-5-17(8-16)18-6-7-19(12-28)29-13-18)21-11-25(36-24(21)10-20)22-14-32-26(30-22)37-27(31-32)34-2/h3-11,13-14H,15H2,1-2H3
PDB

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n/an/a 4.91n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286413
PNG
(US9518064, Example 24)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccc(OC)n3)cc(OC)cc2o1
Show InChI InChI=1S/C27H22N4O5S/c1-32-18-11-22(35-15-16-6-4-7-17(10-16)20-8-5-9-25(28-20)33-2)19-13-24(36-23(19)12-18)21-14-31-26(29-21)37-27(30-31)34-3/h4-14H,15H2,1-3H3
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n/an/a 6.31n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286405
PNG
(US9518064, Example 15)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccnc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N4O4S/c1-31-19-10-22(33-15-16-5-3-6-17(9-16)18-7-4-8-27-13-18)20-12-24(34-23(20)11-19)21-14-30-25(28-21)35-26(29-30)32-2/h3-14H,15H2,1-2H3
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n/an/a 6.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286458
PNG
(US9518064, Example 76)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(n3)-c3ccc(Cl)nc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H18ClN5O4S/c1-32-16-8-20(34-13-15-4-3-5-18(28-15)14-6-7-23(26)27-11-14)17-10-22(35-21(17)9-16)19-12-31-24(29-19)36-25(30-31)33-2/h3-12H,13H2,1-2H3
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n/an/a 6.66n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286454
PNG
(US9518064, Example 72)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cncc(c3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N4O4S/c1-31-19-9-22(33-15-16-8-18(13-27-12-16)17-6-4-3-5-7-17)20-11-24(34-23(20)10-19)21-14-30-25(28-21)35-26(29-30)32-2/h3-14H,15H2,1-2H3
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n/an/a 7.19n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286411
PNG
(US9518064, Example 21)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnc4ccccn34)cc(OC)cc2o1
Show InChI InChI=1S/C28H21N5O4S/c1-34-19-11-23(20-13-25(37-24(20)12-19)21-15-33-27(30-21)38-28(31-33)35-2)36-16-17-6-5-7-18(10-17)22-14-29-26-8-3-4-9-32(22)26/h3-15H,16H2,1-2H3
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n/an/a 7.34n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286410
PNG
(US9518064, Example 20)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc4nsnc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H19N5O4S2/c1-33-18-10-23(19-12-25(36-24(19)11-18)22-13-32-26(28-22)37-27(29-32)34-2)35-14-15-4-3-5-16(8-15)17-6-7-20-21(9-17)31-38-30-20/h3-13H,14H2,1-2H3
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n/an/a 8.54n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286425
PNG
(US9518064, Example 41)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3coc(c3)C(N)=O)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N4O6S/c1-32-17-8-20(34-12-14-4-3-5-15(6-14)16-7-23(24(27)31)35-13-16)18-10-22(36-21(18)9-17)19-11-30-25(28-19)37-26(29-30)33-2/h3-11,13H,12H2,1-2H3,(H2,27,31)
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286472
PNG
(US9518064, Example 91)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(O)cn3)cc(OC)cc2o1
Show InChI InChI=1S/C26H20N4O5S/c1-32-18-9-22(34-14-15-4-3-5-16(8-15)20-7-6-17(31)12-27-20)19-11-24(35-23(19)10-18)21-13-30-25(28-21)36-26(29-30)33-2/h3-13,31H,14H2,1-2H3
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n/an/a 9.05n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286392
PNG
(US9518064, Example 4)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cc4ccccc4s3)cc(OC)cc2o1
Show InChI InChI=1S/C29H21N3O4S2/c1-33-20-12-23(21-14-25(36-24(21)13-20)22-15-32-28(30-22)38-29(31-32)34-2)35-16-17-6-5-8-18(10-17)27-11-19-7-3-4-9-26(19)37-27/h3-15H,16H2,1-2H3
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n/an/a 9.35n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286503
PNG
(US9518064, Example 69)
Show SMILES COc1cc(OCc2cccc(c2)-c2ccc(F)cn2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1S/C27H20F2N4O3S/c1-15(28)26-32-33-13-22(31-27(33)37-26)25-11-20-23(9-19(34-2)10-24(20)36-25)35-14-16-4-3-5-17(8-16)21-7-6-18(29)12-30-21/h3-13,15H,14H2,1-2H3/t15-/m0/s1
PDB

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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286462
PNG
(4-((3-(Furan-3-yl)benzyl)oxy)-2-(2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1nc2c(OCc3cccc(c3)-c3ccoc3)cccc2o1
Show InChI InChI=1S/C23H16N4O4S/c1-28-23-26-27-11-17(24-22(27)32-23)21-25-20-18(6-3-7-19(20)31-21)30-12-14-4-2-5-15(10-14)16-8-9-29-13-16/h2-11,13H,12H2,1H3
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Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286412
PNG
(US9518064, Example 22)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc4nncn4c3)cc(OC)cc2o1
Show InChI InChI=1S/C27H20N6O4S/c1-34-19-9-22(20-11-24(37-23(20)10-19)21-13-33-26(29-21)38-27(31-33)35-2)36-14-16-4-3-5-17(8-16)18-6-7-25-30-28-15-32(25)12-18/h3-13,15H,14H2,1-2H3
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n/an/a 23.6n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286498
PNG
(US9518064, Example 28)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)[N+]([O-])=O)cc(OC)cc2o1
Show InChI InChI=1S/C26H19N5O6S/c1-34-18-9-21(36-14-15-4-3-5-16(8-15)17-6-7-24(27-12-17)31(32)33)19-11-23(37-22(19)10-18)20-13-30-25(28-20)38-26(29-30)35-2/h3-13H,14H2,1-2H3
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n/an/a 24.6n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286480
PNG
(US9518064, Example 99)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3ccnc(n3)-c3cccc(c3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C26H18N6O4S/c1-33-18-9-21(35-14-17-6-7-28-24(29-17)16-5-3-4-15(8-16)12-27)19-11-23(36-22(19)10-18)20-13-32-25(30-20)37-26(31-32)34-2/h3-11,13H,14H2,1-2H3
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n/an/a 48.7n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286501
PNG
(US9518064, Example 31)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc4OCCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C29H23N3O6S/c1-33-20-12-24(21-14-26(38-25(21)13-20)22-15-32-28(30-22)39-29(31-32)34-2)37-16-17-4-3-5-18(10-17)19-6-7-23-27(11-19)36-9-8-35-23/h3-7,10-15H,8-9,16H2,1-2H3
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n/an/a 49.9n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286465
PNG
(5-(3-(((6-Methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)C(O)=O)cc(OC)cc2o1
Show InChI InChI=1S/C27H20N4O6S/c1-34-18-9-22(36-14-15-4-3-5-16(8-15)17-6-7-20(25(32)33)28-12-17)19-11-24(37-23(19)10-18)21-13-31-26(29-21)38-27(30-31)35-2/h3-13H,14H2,1-2H3,(H,32,33)
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n/an/a 65n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286432
PNG
(US9518064, Example 48)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cnsc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O4S2/c1-29-17-7-20(31-12-14-4-3-5-15(6-14)16-10-25-33-13-16)18-9-22(32-21(18)8-17)19-11-28-23(26-19)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
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n/an/a 65.9n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286406
PNG
(US9518064, Example 16)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cc3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N3O4S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-34-26(32-22)39-27(33-34)36-2)37-15-16-4-3-5-18(10-16)17-6-8-19(9-7-17)28(29,30)31/h3-14H,15H2,1-2H3
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n/an/a 67n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286408
PNG
(US9518064, Example 18)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc4OCOc4c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21N3O6S/c1-32-19-10-23(20-12-25(37-24(20)11-19)21-13-31-27(29-21)38-28(30-31)33-2)34-14-16-4-3-5-17(8-16)18-6-7-22-26(9-18)36-15-35-22/h3-13H,14-15H2,1-2H3
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n/an/a 68.2n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286444
PNG
(US9518064, Example 60)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)C(=O)OC(C)(C)C)cc(OC)cc2o1
Show InChI InChI=1S/C31H28N4O6S/c1-31(2,3)41-28(36)23-10-9-20(15-32-23)19-8-6-7-18(11-19)17-39-25-12-21(37-4)13-26-22(25)14-27(40-26)24-16-35-29(33-24)42-30(34-35)38-5/h6-16H,17H2,1-5H3
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n/an/a 81.3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286491
PNG
((S)-4-(6-(((2-(2-(1-Fluoroethyl)imidazo[2,1-b][1,3...)
Show SMILES COc1cc(OCc2cccc(n2)C2(O)CCOCC2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1S/C26H25FN4O5S/c1-15(27)24-30-31-13-19(29-25(31)37-24)22-12-18-20(10-17(33-2)11-21(18)36-22)35-14-16-4-3-5-23(28-16)26(32)6-8-34-9-7-26/h3-5,10-13,15,32H,6-9,14H2,1-2H3/t15-/m0/s1
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n/an/a 87.6n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286499
PNG
(US9518064, Example 29)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(cc3)C#N)cc(OC)cc2o1
Show InChI InChI=1S/C28H20N4O4S/c1-33-21-11-24(35-16-18-4-3-5-20(10-18)19-8-6-17(14-29)7-9-19)22-13-26(36-25(22)12-21)23-15-32-27(30-23)37-28(31-32)34-2/h3-13,15H,16H2,1-2H3
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n/an/a 93.4n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286474
PNG
(US9518064, Example 93)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)C3=CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C26H23N3O5S/c1-30-19-11-22(33-15-16-4-3-5-18(10-16)17-6-8-32-9-7-17)20-13-24(34-23(20)12-19)21-14-29-25(27-21)35-26(28-29)31-2/h3-6,10-14H,7-9,15H2,1-2H3
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n/an/a 105n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286500
PNG
(US9518064, Example 30)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(C#N)c(F)c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H19FN4O4S/c1-34-20-10-24(36-15-16-4-3-5-17(8-16)18-6-7-19(13-30)22(29)9-18)21-12-26(37-25(21)11-20)23-14-33-27(31-23)38-28(32-33)35-2/h3-12,14H,15H2,1-2H3
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n/an/a 125n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286502
PNG
((S)-2-(1-Fluoroethyl)-6-(6-methoxy-4-((3-(pyrimidi...)
Show SMILES COc1cc(OCc2cccc(c2)-c2cncnc2)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F
Show InChI InChI=1S/C26H20FN5O3S/c1-15(27)25-31-32-12-21(30-26(32)36-25)24-9-20-22(7-19(33-2)8-23(20)35-24)34-13-16-4-3-5-17(6-16)18-10-28-14-29-11-18/h3-12,14-15H,13H2,1-2H3/t15-/m0/s1
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n/an/a 490n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286496
PNG
(US9518064, Example 23)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc4nccn4c3)cc(OC)cc2o1
Show InChI InChI=1S/C28H21N5O4S/c1-34-20-11-23(21-13-25(37-24(21)12-20)22-15-33-27(30-22)38-28(31-33)35-2)36-16-17-4-3-5-18(10-17)19-6-7-26-29-8-9-32(26)14-19/h3-15H,16H2,1-2H3
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n/an/a 629n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286497
PNG
(US9518064, Example 26)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccnc3C#N)cc(OC)cc2o1
Show InChI InChI=1S/C27H19N5O4S/c1-33-18-10-23(35-15-16-5-3-6-17(9-16)19-7-4-8-29-21(19)13-28)20-12-25(36-24(20)11-18)22-14-32-26(30-22)37-27(31-32)34-2/h3-12,14H,15H2,1-2H3
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n/an/a 970n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286451
PNG
(US9518064, Example 68)
Show SMILES COc1cc(OCc2cccc(c2)-c2ccc(F)nc2)c2cc(oc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C27H19F3N4O3S/c1-27(29,30)25-33-34-13-20(32-26(34)38-25)23-11-19-21(9-18(35-2)10-22(19)37-23)36-14-15-4-3-5-16(8-15)17-6-7-24(28)31-12-17/h3-13H,14H2,1-2H3
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n/an/a 2.23E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286447
PNG
(2-(1,1-Difluoroethyl)-6-(6-methoxy-4-((3-(pyrimidi...)
Show SMILES COc1cc(OCc2cccc(c2)-c2cncnc2)c2cc(oc2c1)-c1cn2nc(sc2n1)C(C)(F)F
Show InChI InChI=1S/C26H19F2N5O3S/c1-26(27,28)24-32-33-12-20(31-25(33)37-24)23-9-19-21(7-18(34-2)8-22(19)36-23)35-13-15-4-3-5-16(6-15)17-10-29-14-30-11-17/h3-12,14H,13H2,1-2H3
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n/an/a 2.43E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286443
PNG
(US9518064, Example 59)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(nc3)N3CCOCC3)cc(OC)cc2o1
Show InChI InChI=1S/C30H27N5O5S/c1-36-22-13-25(23-15-27(40-26(23)14-22)24-17-35-29(32-24)41-30(33-35)37-2)39-18-19-4-3-5-20(12-19)21-6-7-28(31-16-21)34-8-10-38-11-9-34/h3-7,12-17H,8-11,18H2,1-2H3
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n/an/a 2.67E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286416
PNG
(US9518064, Example 32)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(F)c(C)n3)cc(OC)cc2o1
Show InChI InChI=1S/C27H21FN4O4S/c1-15-20(28)7-8-21(29-15)17-6-4-5-16(9-17)14-35-23-10-18(33-2)11-24-19(23)12-25(36-24)22-13-32-26(30-22)37-27(31-32)34-3/h4-13H,14H2,1-3H3
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n/an/a 2.77E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
par4 flipr assay


(Homo sapiens (Human))
BDBM286461
PNG
(US9518064, Example 80)
Show SMILES CSc1nn2cc(nc2s1)-c1nc2c(OCc3ccccc3-c3ccccc3)cccc2o1
Show InChI InChI=1S/C25H18N4O2S2/c1-32-25-28-29-14-19(26-24(29)33-25)23-27-22-20(12-7-13-21(22)31-23)30-15-17-10-5-6-11-18(17)16-8-3-2-4-9-16/h2-14H,15H2,1H3
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n/an/a 3.13E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286389
PNG
(2-Methoxy-6-(6-methoxy-4-((3′-(trifluorometh...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3cccc(c3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C28H20F3N3O4S/c1-35-20-11-23(21-13-25(38-24(21)12-20)22-14-34-26(32-22)39-27(33-34)36-2)37-15-16-5-3-6-17(9-16)18-7-4-8-19(10-18)28(29,30)31/h3-14H,15H2,1-2H3
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n/an/a 4.46E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
prp assay (gamma thrombin


(Homo sapiens (Human))
BDBM286462
PNG
(4-((3-(Furan-3-yl)benzyl)oxy)-2-(2-methoxyimidazo[...)
Show SMILES COc1nn2cc(nc2s1)-c1nc2c(OCc3cccc(c3)-c3ccoc3)cccc2o1
Show InChI InChI=1S/C23H16N4O4S/c1-28-23-26-27-11-17(24-22(27)32-23)21-25-20-18(6-3-7-19(20)31-21)30-12-14-4-2-5-15(10-14)16-8-9-29-13-16/h2-11,13H,12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company; Universite De Montreal

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9518064 (2016)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%