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Patent code US9522886

Compile Data Set for Download or QSAR
Found 195 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260054
PNG
(US9522886, 1)
Show SMILES CCOC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26N2O5/c1-2-26-17(23)9-20(11-25-12-20)22-18(24)16-8-7-15(14-5-6-14)19(21-16)27-10-13-3-4-13/h7-8,13-14H,2-6,9-12H2,1H3,(H,22,24)
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n/an/an/an/a 53.7n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260072
PNG
(US9522886, 20)
Show SMILES NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O3/c21-20(22)10-26(11-20)16-8-7-15(25-19(16)29-9-12-5-6-12)18(28)24-14-4-2-1-3-13(14)17(23)27/h7-8,12-14H,1-6,9-11H2,(H2,23,27)(H,24,28)/t13-,14+/m1/s1
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n/an/an/an/a 15.8n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260077
PNG
(US9522886, 25)
Show SMILES CC(C)C[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-12(2)9-15(10-18(21)24)22-19(25)17-8-7-16(14-5-6-14)20(23-17)26-11-13-3-4-13/h7-8,12-15H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t15-/m1/s1
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n/an/an/an/a 4.30n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260078
PNG
(US9522886, 26)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O4/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)28-6-11-1-2-11)15(26)23-17(5-14(21)25)9-27-10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26)
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n/an/an/an/a 5.65n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260083
PNG
((żżż)-5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-...)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O3/c18-17(19,20)13(7-14(21)24)23-15(25)12-6-5-11(10-3-4-10)16(22-12)26-8-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,21,24)(H,23,25)
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n/an/an/an/a 8.80n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260093
PNG
(US9522886, 41)
Show SMILES CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O4/c1-25(2)16(27)7-19(11-29-12-19)24-17(28)14-5-6-15(26-9-20(21,22)10-26)18(23-14)30-8-13-3-4-13/h5-6,13H,3-4,7-12H2,1-2H3,(H,24,28)
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n/an/an/an/a 298n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260095
PNG
(US9522886, 43)
Show SMILES NC(=O)C[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H24ClN3O3/c23-16-3-1-2-15(10-16)19(11-20(24)27)25-21(28)18-9-8-17(14-6-7-14)22(26-18)29-12-13-4-5-13/h1-3,8-10,13-14,19H,4-7,11-12H2,(H2,24,27)(H,25,28)/t19-/m1/s1
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n/an/an/an/a 105n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260102
PNG
(US9522886, 50)
Show SMILES COC(=O)CC1(CNC(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H24F2N4O5/c1-30-16(28)7-19(6-15(27)23-9-19)25-17(29)13-4-5-14(26-10-20(21,22)11-26)18(24-13)31-8-12-2-3-12/h4-5,12H,2-3,6-11H2,1H3,(H,23,27)(H,25,29)
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n/an/an/an/a 423n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260103
PNG
(US9522886, 51)
Show SMILES CCOC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N3O6S/c1-2-30-16(26)7-19(11-32(28,29)12-19)24-17(27)14-5-6-15(25-9-20(21,22)10-25)18(23-14)31-8-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,24,27)
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n/an/an/an/a 57n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260121
PNG
(US9522886, 69)
Show SMILES OC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23F2N3O4/c20-19(21)10-24(11-19)14-5-4-13(22-17(14)28-9-12-2-3-12)16(27)23-18(6-1-7-18)8-15(25)26/h4-5,12H,1-3,6-11H2,(H,23,27)(H,25,26)
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n/an/an/an/a 302n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260122
PNG
(US9522886, 70)
Show SMILES NC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O3/c20-19(21)10-25(11-19)14-5-4-13(23-17(14)28-9-12-2-3-12)16(27)24-18(6-1-7-18)8-15(22)26/h4-5,12H,1-3,6-11H2,(H2,22,26)(H,24,27)
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n/an/an/an/a 0.600n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260134
PNG
(US9522886, 82)
Show SMILES NC(=O)CC1(CCOC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O4/c20-19(21)9-25(10-19)14-4-3-13(23-17(14)29-8-12-1-2-12)16(27)24-18(7-15(22)26)5-6-28-11-18/h3-4,12H,1-2,5-11H2,(H2,22,26)(H,24,27)
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n/an/an/an/a 1.5n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260138
PNG
(US9522886, 86)
Show SMILES NC(=O)CC1(CCNCC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28N4O3/c21-17(25)11-20(7-9-22-10-8-20)24-18(26)16-6-5-15(14-3-4-14)19(23-16)27-12-13-1-2-13/h5-6,13-14,22H,1-4,7-12H2,(H2,21,25)(H,24,26)
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n/an/an/an/a 240n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260144
PNG
(US9522886, 92)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1
Show InChI InChI=1S/C19H25N3O6S/c20-15(23)8-18(10-29(26,27)11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)28-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24)
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n/an/an/an/a 2.20n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260147
PNG
(US9522886, 95)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1
Show InChI InChI=1S/C19H25N3O4S/c20-15(23)8-18(10-27-11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)26-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24)
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n/an/an/an/a 1.10n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260056
PNG
(US9522886, 4)
Show SMILES CCOC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1
Show InChI InChI=1S/C24H27F2N3O4/c1-2-32-21(30)12-19(17-6-4-3-5-7-17)27-22(31)18-10-11-20(29-14-24(25,26)15-29)23(28-18)33-13-16-8-9-16/h3-7,10-11,16,19H,2,8-9,12-15H2,1H3,(H,27,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260078
PNG
(US9522886, 26)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O4/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)28-6-11-1-2-11)15(26)23-17(5-14(21)25)9-27-10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260079
PNG
(US9522886, 27 | US9522886, 28)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H25N3O3/c20-17(23)9-16(13-5-6-13)21-18(24)15-8-7-14(12-3-4-12)19(22-15)25-10-11-1-2-11/h7-8,11-13,16H,1-6,9-10H2,(H2,20,23)(H,21,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260085
PNG
(US9522886, 33)
Show SMILES CC(Oc1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)COC1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O4/c1-9(17(18,19)20)27-15-11(10-2-3-10)4-5-12(22-15)14(25)23-16(6-13(21)24)7-26-8-16/h4-5,9-10H,2-3,6-8H2,1H3,(H2,21,24)(H,23,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260092
PNG
(US9522886, 40)
Show SMILES CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O4/c1-23(2)17(24)9-20(11-26-12-20)22-18(25)16-8-7-15(14-5-6-14)19(21-16)27-10-13-3-4-13/h7-8,13-14H,3-6,9-12H2,1-2H3,(H,22,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260121
PNG
(US9522886, 69)
Show SMILES OC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23F2N3O4/c20-19(21)10-24(11-19)14-5-4-13(22-17(14)28-9-12-2-3-12)16(27)23-18(6-1-7-18)8-15(25)26/h4-5,12H,1-3,6-11H2,(H,23,27)(H,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260127
PNG
(US9522886, 75)
Show SMILES CC(C)CSc1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1
Show InChI InChI=1S/C18H25N3O4S2/c1-11(2)8-26-17-13(12-3-4-12)5-6-14(20-17)16(23)21-18(7-15(19)22)9-27(24,25)10-18/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,19,22)(H,21,23)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260057
PNG
(US9522886, 5)
Show SMILES CCOC(=O)CC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N3O4/c1-4-28-16(26)9-19(2,3)24-17(27)14-7-8-15(25-11-20(21,22)12-25)18(23-14)29-10-13-5-6-13/h7-8,13H,4-6,9-12H2,1-3H3,(H,24,27)
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n/an/an/an/a 518n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260064
PNG
(US9522886, 12 | US9522886, 15)
Show SMILES NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16+/m1/s1
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n/an/an/an/a 15.9n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260066
PNG
(US9522886, 14)
Show SMILES CC(C)[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c1-11(2)16(9-17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,3-6,9-10H2,1-2H3,(H2,20,23)(H,21,24)/t16-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260069
PNG
(US9522886, 17 | US9522886, 18)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCCCC1
Show InChI InChI=1S/C22H31N3O3/c23-20(26)12-19(16-4-2-1-3-5-16)24-21(27)18-11-10-17(15-8-9-15)22(25-18)28-13-14-6-7-14/h10-11,14-16,19H,1-9,12-13H2,(H2,23,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260082
PNG
(US9522886, 30 | US9522886, 34)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H29N3O4/c22-19(25)11-18(15-7-9-27-10-8-15)23-20(26)17-6-5-16(14-3-4-14)21(24-17)28-12-13-1-2-13/h5-6,13-15,18H,1-4,7-12H2,(H2,22,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260090
PNG
(US9522886, 38)
Show SMILES CNC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25N3O4/c1-20-16(23)8-19(10-25-11-19)22-17(24)15-7-6-14(13-4-5-13)18(21-15)26-9-12-2-3-12/h6-7,12-13H,2-5,8-11H2,1H3,(H,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260091
PNG
(US9522886, 39)
Show SMILES CNC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O4/c1-21-13(24)6-16(8-26-9-16)23-14(25)12-5-4-11(17(18,19)20)15(22-12)27-7-10-2-3-10/h4-5,10H,2-3,6-9H2,1H3,(H,21,24)(H,23,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260098
PNG
(US9522886, 46)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(OC(F)(F)F)c(OCC2CC2)n1
Show InChI InChI=1S/C16H18F3N3O5/c17-16(18,19)27-11-4-3-10(21-14(11)26-6-9-1-2-9)13(24)22-15(5-12(20)23)7-25-8-15/h3-4,9H,1-2,5-8H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260106
PNG
(US9522886, 54)
Show SMILES NC(=O)CC1(CNC(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23F2N5O4/c20-19(21)9-26(10-19)13-4-3-12(24-17(13)30-7-11-1-2-11)16(29)25-18(5-14(22)27)6-15(28)23-8-18/h3-4,11H,1-2,5-10H2,(H2,22,27)(H,23,28)(H,25,29)
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n/an/an/an/a 55n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260116
PNG
(US9522886, 64)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOC1
Show InChI InChI=1S/C20H27N3O4/c21-18(24)9-17(14-7-8-26-11-14)22-19(25)16-6-5-15(13-3-4-13)20(23-16)27-10-12-1-2-12/h5-6,12-14,17H,1-4,7-11H2,(H2,21,24)(H,22,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260135
PNG
(US9522886, 83)
Show SMILES NC(=O)CC1(CCN(C1)C(=O)OCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C27H31F2N5O5/c28-27(29)16-34(17-27)21-9-8-20(31-24(21)38-13-19-6-7-19)23(36)32-26(12-22(30)35)10-11-33(15-26)25(37)39-14-18-4-2-1-3-5-18/h1-5,8-9,19H,6-7,10-17H2,(H2,30,35)(H,32,36)
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n/an/an/an/a 1.33E+3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260136
PNG
(US9522886, 84)
Show SMILES NC(=O)CC1(CCNC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c20-19(21)10-26(11-19)14-4-3-13(24-17(14)29-8-12-1-2-12)16(28)25-18(7-15(22)27)5-6-23-9-18/h3-4,12,23H,1-2,5-11H2,(H2,22,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260142
PNG
(US9522886, 90)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1
Show InChI InChI=1S/C19H25N3O5/c20-15(23)8-18(10-26-11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)27-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260054
PNG
(US9522886, 1)
Show SMILES CCOC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26N2O5/c1-2-26-17(23)9-20(11-25-12-20)22-18(24)16-8-7-15(14-5-6-14)19(21-16)27-10-13-3-4-13/h7-8,13-14H,2-6,9-12H2,1H3,(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260058
PNG
(US9522886, 6)
Show SMILES CNC(=O)CC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c1-18(2,8-15(26)22-3)24-16(27)13-6-7-14(25-10-19(20,21)11-25)17(23-13)28-9-12-4-5-12/h6-7,12H,4-5,8-11H2,1-3H3,(H,22,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260063
PNG
(US9522886, 11)
Show SMILES CC(C)CC(CNC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(O)=O
Show InChI InChI=1S/C20H27F2N3O4/c1-12(2)7-14(19(27)28)8-23-17(26)15-5-6-16(25-10-20(21,22)11-25)18(24-15)29-9-13-3-4-13/h5-6,12-14H,3-4,7-11H2,1-2H3,(H,23,26)(H,27,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260064
PNG
(US9522886, 12 | US9522886, 15)
Show SMILES NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16+/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260065
PNG
(US9522886, 13)
Show SMILES CC(C)[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c1-11(2)16(9-17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,3-6,9-10H2,1-2H3,(H2,20,23)(H,21,24)/t16-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260076
PNG
(US9522886, 24)
Show SMILES CC(C)C[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-12(2)9-15(10-18(21)24)22-19(25)17-8-7-16(14-5-6-14)20(23-17)26-11-13-3-4-13/h7-8,12-15H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t15-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260082
PNG
(US9522886, 30 | US9522886, 34)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H29N3O4/c22-19(25)11-18(15-7-9-27-10-8-15)23-20(26)17-6-5-16(14-3-4-14)21(24-17)28-12-13-1-2-13/h5-6,13-15,18H,1-4,7-12H2,(H2,22,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260099
PNG
(US9522886, 47)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(OCC2CC2)c(Cl)n1
Show InChI InChI=1S/C15H18ClN3O4/c16-13-11(23-6-9-1-2-9)4-3-10(18-13)14(21)19-15(5-12(17)20)7-22-8-15/h3-4,9H,1-2,5-8H2,(H2,17,20)(H,19,21)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260101
PNG
(US9522886, 49)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1
Show InChI InChI=1S/C17H18F5N3O4/c18-16(19,17(20,21)22)8-29-14-10(9-1-2-9)3-4-11(24-14)13(27)25-15(5-12(23)26)6-28-7-15/h3-4,9H,1-2,5-8H2,(H2,23,26)(H,25,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260103
PNG
(US9522886, 51)
Show SMILES CCOC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N3O6S/c1-2-30-16(26)7-19(11-32(28,29)12-19)24-17(27)14-5-6-15(25-9-20(21,22)10-25)18(23-14)31-8-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,24,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260132
PNG
(US9522886, 80)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1
Show InChI InChI=1S/C19H25N3O6S/c20-16(23)8-19(10-29(25,26)11-19)22-17(24)15-6-5-14(12-3-4-12)18(21-15)28-9-13-2-1-7-27-13/h5-6,12-13H,1-4,7-11H2,(H2,20,23)(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260138
PNG
(US9522886, 86)
Show SMILES NC(=O)CC1(CCNCC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H28N4O3/c21-17(25)11-20(7-9-22-10-8-20)24-18(26)16-6-5-15(14-3-4-14)19(23-16)27-12-13-1-2-13/h5-6,13-14,22H,1-4,7-12H2,(H2,21,25)(H,24,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260058
PNG
(US9522886, 6)
Show SMILES CNC(=O)CC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c1-18(2,8-15(26)22-3)24-16(27)13-6-7-14(25-10-19(20,21)11-25)17(23-13)28-9-12-4-5-12/h6-7,12H,4-5,8-11H2,1-3H3,(H,22,26)(H,24,27)
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n/an/an/an/a 172n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260063
PNG
(US9522886, 11)
Show SMILES CC(C)CC(CNC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(O)=O
Show InChI InChI=1S/C20H27F2N3O4/c1-12(2)7-14(19(27)28)8-23-17(26)15-5-6-16(25-10-20(21,22)11-25)18(24-15)29-9-13-3-4-13/h5-6,12-14H,3-4,7-11H2,1-2H3,(H,23,26)(H,27,28)
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n/an/an/an/a 967n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260081
PNG
(US9522886, 29)
Show SMILES CC(C)(C)[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-20(2,3)16(10-17(21)24)23-18(25)15-9-8-14(13-6-7-13)19(22-15)26-11-12-4-5-12/h8-9,12-13,16H,4-7,10-11H2,1-3H3,(H2,21,24)(H,23,25)/t16-/m1/s1
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n/an/an/an/a 23.2n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260087
PNG
(US9522886, 35)
Show SMILES CC(C)(C)[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-20(2,3)16(10-17(21)24)23-18(25)15-9-8-14(13-6-7-13)19(22-15)26-11-12-4-5-12/h8-9,12-13,16H,4-7,10-11H2,1-3H3,(H2,21,24)(H,23,25)/t16-/m0/s1
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n/an/an/an/a 0.600n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260105
PNG
(US9522886, 53 | US9522886, 58 | US9522886, 59)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29)
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n/an/an/an/a 18n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260105
PNG
(US9522886, 53 | US9522886, 58 | US9522886, 59)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29)
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n/an/an/an/a 18n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260119
PNG
(US9522886, 67)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOC1
Show InChI InChI=1S/C20H26F2N4O4/c21-20(22)10-26(11-20)16-4-3-14(25-19(16)30-8-12-1-2-12)18(28)24-15(7-17(23)27)13-5-6-29-9-13/h3-4,12-13,15H,1-2,5-11H2,(H2,23,27)(H,24,28)
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n/an/an/an/a 8.30n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260129
PNG
(US9522886, 77)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N3O5S/c19-15(22)7-18(9-27(24,25)10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)26-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23)
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n/an/an/an/a 0.700n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260149
PNG
(US9522886, 97)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C16H18F3N3O3S/c17-16(18,19)10-3-4-11(21-14(10)25-6-9-1-2-9)13(24)22-15(5-12(20)23)7-26-8-15/h3-4,9H,1-2,5-8H2,(H2,20,23)(H,22,24)
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n/an/an/an/a 11.5n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260055
PNG
(US9522886, 2)
Show SMILES CC(C)CC(CC(=O)OC(C)(C)C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C24H35F2N3O4/c1-15(2)10-17(11-20(30)33-23(3,4)5)27-21(31)18-8-9-19(29-13-24(25,26)14-29)22(28-18)32-12-16-6-7-16/h8-9,15-17H,6-7,10-14H2,1-5H3,(H,27,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260057
PNG
(US9522886, 5)
Show SMILES CCOC(=O)CC(C)(C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N3O4/c1-4-28-16(26)9-19(2,3)24-17(27)14-7-8-15(25-11-20(21,22)12-25)18(23-14)29-10-13-5-6-13/h7-8,13H,4-6,9-12H2,1-3H3,(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260071
PNG
(US9522886, 19)
Show SMILES CC(C)[C@H](CC(N)=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c1-11(2)14(7-16(22)26)23-17(27)13-5-6-15(25-9-19(20,21)10-25)18(24-13)28-8-12-3-4-12/h5-6,11-12,14H,3-4,7-10H2,1-2H3,(H2,22,26)(H,23,27)/t14-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260072
PNG
(US9522886, 20)
Show SMILES NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O3/c21-20(22)10-26(11-20)16-8-7-15(25-19(16)29-9-12-5-6-12)18(28)24-14-4-2-1-3-13(14)17(23)27/h7-8,12-14H,1-6,9-11H2,(H2,23,27)(H,24,28)/t13-,14+/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260075
PNG
(US9522886, 23)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N3O4/c19-15(22)7-18(9-24-10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)25-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260088
PNG
(US9522886, 36)
Show SMILES CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)COC1
Show InChI InChI=1S/C18H25N3O5S/c1-11(2)8-27(24,25)17-13(12-3-4-12)5-6-14(20-17)16(23)21-18(7-15(19)22)9-26-10-18/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,19,22)(H,21,23)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260093
PNG
(US9522886, 41)
Show SMILES CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O4/c1-25(2)16(27)7-19(11-29-12-19)24-17(28)14-5-6-15(26-9-20(21,22)10-26)18(23-14)30-8-13-3-4-13/h5-6,13H,3-4,7-12H2,1-2H3,(H,24,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260100
PNG
(US9522886, 48)
Show SMILES CC(C)(CC(N)=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H24F2N4O3/c1-17(2,7-14(21)25)23-15(26)12-5-6-13(24-9-18(19,20)10-24)16(22-12)27-8-11-3-4-11/h5-6,11H,3-4,7-10H2,1-2H3,(H2,21,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260107
PNG
(US9522886, 55)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H19F5N4O3/c18-16(19)7-26(8-16)11-4-3-10(24-15(11)29-6-9-1-2-9)14(28)25-12(5-13(23)27)17(20,21)22/h3-4,9,12H,1-2,5-8H2,(H2,23,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260114
PNG
(US9522886, 62)
Show SMILES NC(=O)CC1(CCSCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O3S/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)29-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-30-8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260118
PNG
(US9522886, 66)
Show SMILES NC(=O)CC1(CC[NH2+]CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C23H27FN4O2/c24-17-5-1-15(2-6-17)13-20-18(16-3-4-16)7-8-19(27-20)22(30)28-23(14-21(25)29)9-11-26-12-10-23/h1-2,5-8,16,26H,3-4,9-14H2,(H2,25,29)(H,28,30)/p+1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260122
PNG
(US9522886, 70)
Show SMILES NC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O3/c20-19(21)10-25(11-19)14-5-4-13(23-17(14)28-9-12-2-3-12)16(27)24-18(6-1-7-18)8-15(22)26/h4-5,12H,1-3,6-11H2,(H2,22,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260130
PNG
(US9522886, 78)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(c(OCC2CCOCC2)n1)C(F)(F)F
Show InChI InChI=1S/C18H22F3N3O6S/c19-18(20,21)12-1-2-13(23-16(12)30-8-11-3-5-29-6-4-11)15(26)24-17(7-14(22)25)9-31(27,28)10-17/h1-2,11H,3-10H2,(H2,22,25)(H,24,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260065
PNG
(US9522886, 13)
Show SMILES CC(C)[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c1-11(2)16(9-17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,3-6,9-10H2,1-2H3,(H2,20,23)(H,21,24)/t16-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260074
PNG
(US9522886, 22)
Show SMILES CCOC(=O)CC(CC(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C22H32N2O4/c1-4-27-20(25)12-17(11-14(2)3)23-21(26)19-10-9-18(16-7-8-16)22(24-19)28-13-15-5-6-15/h9-10,14-17H,4-8,11-13H2,1-3H3,(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260082
PNG
(US9522886, 30 | US9522886, 34)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H29N3O4/c22-19(25)11-18(15-7-9-27-10-8-15)23-20(26)17-6-5-16(14-3-4-14)21(24-17)28-12-13-1-2-13/h5-6,13-15,18H,1-4,7-12H2,(H2,22,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260089
PNG
(US9522886, 37)
Show SMILES CNC(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O4/c1-22-15(26)6-18(10-28-11-18)24-16(27)13-4-5-14(25-8-19(20,21)9-25)17(23-13)29-7-12-2-3-12/h4-5,12H,2-3,6-11H2,1H3,(H,22,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260100
PNG
(US9522886, 48)
Show SMILES CC(C)(CC(N)=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H24F2N4O3/c1-17(2,7-14(21)25)23-15(26)12-5-6-13(24-9-18(19,20)10-24)16(22-12)27-8-11-3-4-11/h5-6,11H,3-4,7-10H2,1-2H3,(H2,21,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260101
PNG
(US9522886, 49)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC(F)(F)C(F)(F)F)n1
Show InChI InChI=1S/C17H18F5N3O4/c18-16(19,17(20,21)22)8-29-14-10(9-1-2-9)3-4-11(24-14)13(27)25-15(5-12(23)26)6-28-7-15/h3-4,9H,1-2,5-8H2,(H2,23,26)(H,25,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260104
PNG
(US9522886, 52)
Show SMILES COC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H27F2N3O5/c1-29-17(27)10-20(6-8-30-9-7-20)25-18(28)15-4-5-16(26-12-21(22,23)13-26)19(24-15)31-11-14-2-3-14/h4-5,14H,2-3,6-13H2,1H3,(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260108
PNG
(US9522886, 56)
Show SMILES OC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H21F2N3O6S/c19-18(20)7-23(8-18)13-4-3-12(21-16(13)29-6-11-1-2-11)15(26)22-17(5-14(24)25)9-30(27,28)10-17/h3-4,11H,1-2,5-10H2,(H,22,26)(H,24,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260130
PNG
(US9522886, 78)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(c(OCC2CCOCC2)n1)C(F)(F)F
Show InChI InChI=1S/C18H22F3N3O6S/c19-18(20,21)12-1-2-13(23-16(12)30-8-11-3-5-29-6-4-11)15(26)24-17(7-14(22)25)9-31(27,28)10-17/h1-2,11H,3-10H2,(H2,22,25)(H,24,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260139
PNG
(US9522886, 87)
Show SMILES NC(=O)CC1(CCOC1)NC(=O)c1ccc(C2CC2)c(Oc2ccc(F)cc2)n1
Show InChI InChI=1S/C21H22FN3O4/c22-14-3-5-15(6-4-14)29-20-16(13-1-2-13)7-8-17(24-20)19(27)25-21(11-18(23)26)9-10-28-12-21/h3-8,13H,1-2,9-12H2,(H2,23,26)(H,25,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260146
PNG
(US9522886, 94)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)COC1
Show InChI InChI=1S/C18H23N3O6/c19-14(22)5-17(7-25-8-17)21-15(23)13-4-3-12(18(24)9-26-10-18)16(20-13)27-6-11-1-2-11/h3-4,11,24H,1-2,5-10H2,(H2,19,22)(H,21,23)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260148
PNG
(US9522886, 96)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N3O3S/c19-15(22)7-18(9-25-10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)24-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260150
PNG
(US9522886, 98)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)COC1
Show InChI InChI=1S/C18H22FN3O4S/c19-18(7-25-8-18)12-3-4-13(21-16(12)26-6-11-1-2-11)15(24)22-17(5-14(20)23)9-27-10-17/h3-4,11H,1-2,5-10H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM210599
PNG
(US9290451, 290 | US9522886, 3)
Show SMILES CN1CC(CC1=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O3/c1-23-7-12(6-15(23)25)21-16(26)13-4-5-14(24-9-18(19,20)10-24)17(22-13)27-8-11-2-3-11/h4-5,11-12H,2-3,6-10H2,1H3,(H,21,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260059
PNG
(US9522886, 7)
Show SMILES CCCCCC(CC(=O)NC)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C22H32F2N4O3/c1-3-4-5-6-16(11-19(29)25-2)26-20(30)17-9-10-18(28-13-22(23,24)14-28)21(27-17)31-12-15-7-8-15/h9-10,15-16H,3-8,11-14H2,1-2H3,(H,25,29)(H,26,30)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260069
PNG
(US9522886, 17 | US9522886, 18)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCCCC1
Show InChI InChI=1S/C22H31N3O3/c23-20(26)12-19(16-4-2-1-3-5-16)24-21(27)18-11-10-17(15-8-9-15)22(25-18)28-13-14-6-7-14/h10-11,14-16,19H,1-9,12-13H2,(H2,23,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260079
PNG
(US9522886, 27 | US9522886, 28)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H25N3O3/c20-17(23)9-16(13-5-6-13)21-18(24)15-8-7-14(12-3-4-12)19(22-15)25-10-11-1-2-11/h7-8,11-13,16H,1-6,9-10H2,(H2,20,23)(H,21,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260087
PNG
(US9522886, 35)
Show SMILES CC(C)(C)[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-20(2,3)16(10-17(21)24)23-18(25)15-9-8-14(13-6-7-13)19(22-15)26-11-12-4-5-12/h8-9,12-13,16H,4-7,10-11H2,1-3H3,(H2,21,24)(H,23,25)/t16-/m0/s1
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n/an/an/an/a 209n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260089
PNG
(US9522886, 37)
Show SMILES CNC(=O)CC1(COC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O4/c1-22-15(26)6-18(10-28-11-18)24-16(27)13-4-5-14(25-8-19(20,21)9-25)17(23-13)29-7-12-2-3-12/h4-5,12H,2-3,6-11H2,1H3,(H,22,26)(H,24,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260094
PNG
(US9522886, 42)
Show SMILES CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C18H22F3N3O4/c1-24(2)14(25)7-17(9-27-10-17)23-15(26)13-6-5-12(18(19,20)21)16(22-13)28-8-11-3-4-11/h5-6,11H,3-4,7-10H2,1-2H3,(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260104
PNG
(US9522886, 52)
Show SMILES COC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C21H27F2N3O5/c1-29-17(27)10-20(6-8-30-9-7-20)25-18(28)15-4-5-16(26-12-21(22,23)13-26)19(24-15)31-11-14-2-3-14/h4-5,14H,2-3,6-13H2,1H3,(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260109
PNG
(US9522886, 57)
Show SMILES OC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N3O5/c21-20(22)11-25(12-20)15-4-3-14(23-18(15)30-10-13-1-2-13)17(28)24-19(9-16(26)27)5-7-29-8-6-19/h3-4,13H,1-2,5-12H2,(H,24,28)(H,26,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260117
PNG
(US9522886, 65)
Show SMILES NC(=O)CC1(CNC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23F2N5O3/c19-18(20)9-25(10-18)13-4-3-12(23-16(13)28-6-11-1-2-11)15(27)24-17(5-14(21)26)7-22-8-17/h3-4,11,22H,1-2,5-10H2,(H2,21,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260120
PNG
(US9522886, 68)
Show SMILES COC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N3O4/c1-28-16(26)9-19(7-2-8-19)24-17(27)14-5-6-15(25-11-20(21,22)12-25)18(23-14)29-10-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260123
PNG
(US9522886, 71)
Show SMILES CCOC(=O)C1(CNC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CC1
Show InChI InChI=1S/C20H25F2N3O4/c1-2-28-18(27)19(7-8-19)10-23-16(26)14-5-6-15(25-11-20(21,22)12-25)17(24-14)29-9-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260129
PNG
(US9522886, 77)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N3O5S/c19-15(22)7-18(9-27(24,25)10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)26-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260135
PNG
(US9522886, 83)
Show SMILES NC(=O)CC1(CCN(C1)C(=O)OCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C27H31F2N5O5/c28-27(29)16-34(17-27)21-9-8-20(31-24(21)38-13-19-6-7-19)23(36)32-26(12-22(30)35)10-11-33(15-26)25(37)39-14-18-4-2-1-3-5-18/h1-5,8-9,19H,6-7,10-17H2,(H2,30,35)(H,32,36)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260137
PNG
(US9522886, 85)
Show SMILES NC(=O)CC1(CCNCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N5O3/c21-20(22)11-27(12-20)15-4-3-14(25-18(15)30-10-13-1-2-13)17(29)26-19(9-16(23)28)5-7-24-8-6-19/h3-4,13,24H,1-2,5-12H2,(H2,23,28)(H,26,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260139
PNG
(US9522886, 87)
Show SMILES NC(=O)CC1(CCOC1)NC(=O)c1ccc(C2CC2)c(Oc2ccc(F)cc2)n1
Show InChI InChI=1S/C21H22FN3O4/c22-14-3-5-15(6-4-14)29-20-16(13-1-2-13)7-8-17(24-20)19(27)25-21(11-18(23)26)9-10-28-12-21/h3-8,13H,1-2,9-12H2,(H2,23,26)(H,25,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260148
PNG
(US9522886, 96)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N3O3S/c19-15(22)7-18(9-25-10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)24-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM210599
PNG
(US9290451, 290 | US9522886, 3)
Show SMILES CN1CC(CC1=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O3/c1-23-7-12(6-15(23)25)21-16(26)13-4-5-14(24-9-18(19,20)10-24)17(22-13)27-8-11-2-3-11/h4-5,11-12H,2-3,6-10H2,1H3,(H,21,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260056
PNG
(US9522886, 4)
Show SMILES CCOC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)c1ccccc1
Show InChI InChI=1S/C24H27F2N3O4/c1-2-32-21(30)12-19(17-6-4-3-5-7-17)27-22(31)18-10-11-20(29-14-24(25,26)15-29)23(28-18)33-13-16-8-9-16/h3-7,10-11,16,19H,2,8-9,12-15H2,1H3,(H,27,31)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260059
PNG
(US9522886, 7)
Show SMILES CCCCCC(CC(=O)NC)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C22H32F2N4O3/c1-3-4-5-6-16(11-19(29)25-2)26-20(30)17-9-10-18(28-13-22(23,24)14-28)21(27-17)31-12-15-7-8-15/h9-10,15-16H,3-8,11-14H2,1-2H3,(H,25,29)(H,26,30)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260060
PNG
(US9522886, 8)
Show SMILES CNC(=O)CC(CCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C25H30F2N4O3/c1-28-22(32)13-19(10-9-17-5-3-2-4-6-17)29-23(33)20-11-12-21(31-15-25(26,27)16-31)24(30-20)34-14-18-7-8-18/h2-6,11-12,18-19H,7-10,13-16H2,1H3,(H,28,32)(H,29,33)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260061
PNG
(US9522886, 10 | US9522886, 9)
Show SMILES CCCCC(CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-2-3-4-15(11-18(21)24)22-19(25)17-10-9-16(14-7-8-14)20(23-17)26-12-13-5-6-13/h9-10,13-15H,2-8,11-12H2,1H3,(H2,21,24)(H,22,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260068
PNG
(US9522886, 16)
Show SMILES NC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260073
PNG
(US9522886, 21)
Show SMILES NC(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O3/c21-20(22)10-26(11-20)16-8-7-15(25-19(16)29-9-12-5-6-12)18(28)24-14-4-2-1-3-13(14)17(23)27/h7-8,12-14H,1-6,9-11H2,(H2,23,27)(H,24,28)/t13-,14+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260076
PNG
(US9522886, 24)
Show SMILES CC(C)C[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-12(2)9-15(10-18(21)24)22-19(25)17-8-7-16(14-5-6-14)20(23-17)26-11-13-3-4-13/h7-8,12-15H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t15-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260092
PNG
(US9522886, 40)
Show SMILES CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O4/c1-23(2)17(24)9-20(11-26-12-20)22-18(25)16-8-7-15(14-5-6-14)19(21-16)27-10-13-3-4-13/h7-8,13-14H,3-6,9-12H2,1-2H3,(H,22,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260096
PNG
(US9522886, 44)
Show SMILES CC(C)S(=O)c1nc(ccc1Br)C(=O)NC1(CC(N)=O)COC1
Show InChI InChI=1S/C14H18BrN3O4S/c1-8(2)23(21)13-9(15)3-4-10(17-13)12(20)18-14(5-11(16)19)6-22-7-14/h3-4,8H,5-7H2,1-2H3,(H2,16,19)(H,18,20)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260099
PNG
(US9522886, 47)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(OCC2CC2)c(Cl)n1
Show InChI InChI=1S/C15H18ClN3O4/c16-13-11(23-6-9-1-2-9)4-3-10(18-13)14(21)19-15(5-12(17)20)7-22-8-15/h3-4,9H,1-2,5-8H2,(H2,17,20)(H,19,21)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260107
PNG
(US9522886, 55)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H19F5N4O3/c18-16(19)7-26(8-16)11-4-3-10(24-15(11)29-6-9-1-2-9)14(28)25-12(5-13(23)27)17(20,21)22/h3-4,9,12H,1-2,5-8H2,(H2,23,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260123
PNG
(US9522886, 71)
Show SMILES CCOC(=O)C1(CNC(=O)c2ccc(N3CC(F)(F)C3)c(OCC3CC3)n2)CC1
Show InChI InChI=1S/C20H25F2N3O4/c1-2-28-18(27)19(7-8-19)10-23-16(26)14-5-6-15(25-11-20(21,22)12-25)17(24-14)29-9-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260124
PNG
(US9522886, 72)
Show SMILES CC(=O)N1CCC(CC(N)=O)(CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C25H29FN4O3/c1-16(31)30-12-10-25(11-13-30,15-23(27)32)29-24(33)21-9-8-20(18-4-5-18)22(28-21)14-17-2-6-19(26)7-3-17/h2-3,6-9,18H,4-5,10-15H2,1H3,(H2,27,32)(H,29,33)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260126
PNG
(US9522886, 74)
Show SMILES NC(=O)CC1(CN(C1)C(=O)OCc1ccccc1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C29H29FN4O4/c30-22-10-6-19(7-11-22)14-25-23(21-8-9-21)12-13-24(32-25)27(36)33-29(15-26(31)35)17-34(18-29)28(37)38-16-20-4-2-1-3-5-20/h1-7,10-13,21H,8-9,14-18H2,(H2,31,35)(H,33,36)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260127
PNG
(US9522886, 75)
Show SMILES CC(C)CSc1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)CS(=O)(=O)C1
Show InChI InChI=1S/C18H25N3O4S2/c1-11(2)8-26-17-13(12-3-4-12)5-6-14(20-17)16(23)21-18(7-15(19)22)9-27(24,25)10-18/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,19,22)(H,21,23)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260132
PNG
(US9522886, 80)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(OCC2CCCO2)n1
Show InChI InChI=1S/C19H25N3O6S/c20-16(23)8-19(10-29(25,26)11-19)22-17(24)15-6-5-14(12-3-4-12)18(21-15)28-9-13-2-1-7-27-13/h5-6,12-13H,1-4,7-11H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260140
PNG
(US9522886, 88)
Show SMILES NC(=O)CC1(CCOC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25N3O4/c20-16(23)9-19(7-8-25-11-19)22-17(24)15-6-5-14(13-3-4-13)18(21-15)26-10-12-1-2-12/h5-6,12-13H,1-4,7-11H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260061
PNG
(US9522886, 10 | US9522886, 9)
Show SMILES CCCCC(CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-2-3-4-15(11-18(21)24)22-19(25)17-10-9-16(14-7-8-14)20(23-17)26-12-13-5-6-13/h9-10,13-15H,2-8,11-12H2,1H3,(H2,21,24)(H,22,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260066
PNG
(US9522886, 14)
Show SMILES CC(C)[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H27N3O3/c1-11(2)16(9-17(20)23)21-18(24)15-8-7-14(13-5-6-13)19(22-15)25-10-12-3-4-12/h7-8,11-13,16H,3-6,9-10H2,1-2H3,(H2,20,23)(H,21,24)/t16-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260064
PNG
(US9522886, 12 | US9522886, 15)
Show SMILES NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16+/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260068
PNG
(US9522886, 16)
Show SMILES NC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16-/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260073
PNG
(US9522886, 21)
Show SMILES NC(=O)[C@H]1CCCC[C@H]1NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O3/c21-20(22)10-26(11-20)16-8-7-15(25-19(16)29-9-12-5-6-12)18(28)24-14-4-2-1-3-13(14)17(23)27/h7-8,12-14H,1-6,9-11H2,(H2,23,27)(H,24,28)/t13-,14+/m0/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260097
PNG
(US9522886, 45)
Show SMILES COC(=O)CC1(CCN(CC1)C(=O)OC(C)(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C26H37N3O6/c1-25(2,3)35-24(32)29-13-11-26(12-14-29,15-21(30)33-4)28-22(31)20-10-9-19(18-7-8-18)23(27-20)34-16-17-5-6-17/h9-10,17-18H,5-8,11-16H2,1-4H3,(H,28,31)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260105
PNG
(US9522886, 53 | US9522886, 58 | US9522886, 59)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260115
PNG
(US9522886, 63)
Show SMILES NC(=O)CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O5S/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)31-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-32(29,30)8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260124
PNG
(US9522886, 72)
Show SMILES CC(=O)N1CCC(CC(N)=O)(CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C25H29FN4O3/c1-16(31)30-12-10-25(11-13-30,15-23(27)32)29-24(33)21-9-8-20(18-4-5-18)22(28-21)14-17-2-6-19(26)7-3-17/h2-3,6-9,18H,4-5,10-15H2,1H3,(H2,27,32)(H,29,33)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260147
PNG
(US9522886, 95)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1
Show InChI InChI=1S/C19H25N3O4S/c20-15(23)8-18(10-27-11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)26-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260061
PNG
(US9522886, 10 | US9522886, 9)
Show SMILES CCCCC(CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-2-3-4-15(11-18(21)24)22-19(25)17-10-9-16(14-7-8-14)20(23-17)26-12-13-5-6-13/h9-10,13-15H,2-8,11-12H2,1H3,(H2,21,24)(H,22,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260084
PNG
((+)-5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-...)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O3/c18-17(19,20)13(7-14(21)24)23-15(25)12-6-5-11(10-3-4-10)16(22-12)26-8-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,21,24)(H,23,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260085
PNG
(US9522886, 33)
Show SMILES CC(Oc1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)COC1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O4/c1-9(17(18,19)20)27-15-11(10-2-3-10)4-5-12(22-15)14(25)23-16(6-13(21)24)7-26-8-16/h4-5,9-10H,2-3,6-8H2,1H3,(H2,21,24)(H,23,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260088
PNG
(US9522886, 36)
Show SMILES CC(C)CS(=O)(=O)c1nc(ccc1C1CC1)C(=O)NC1(CC(N)=O)COC1
Show InChI InChI=1S/C18H25N3O5S/c1-11(2)8-27(24,25)17-13(12-3-4-12)5-6-14(20-17)16(23)21-18(7-15(19)22)9-26-10-18/h5-6,11-12H,3-4,7-10H2,1-2H3,(H2,19,22)(H,21,23)
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n/an/an/an/a 255n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260109
PNG
(US9522886, 57)
Show SMILES OC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N3O5/c21-20(22)11-25(12-20)15-4-3-14(23-18(15)30-10-13-1-2-13)17(28)24-19(9-16(26)27)5-7-29-8-6-19/h3-4,13H,1-2,5-12H2,(H,24,28)(H,26,27)
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n/an/an/an/a 3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260115
PNG
(US9522886, 63)
Show SMILES NC(=O)CC1(CCS(=O)(=O)CC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O5S/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)31-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-32(29,30)8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28)
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n/an/an/an/a 55.5n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260118
PNG
(US9522886, 66)
Show SMILES NC(=O)CC1(CC[NH2+]CC1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C23H27FN4O2/c24-17-5-1-15(2-6-17)13-20-18(16-3-4-16)7-8-19(27-20)22(30)28-23(14-21(25)29)9-11-26-12-10-23/h1-2,5-8,16,26H,3-4,9-14H2,(H2,25,29)(H,28,30)/p+1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260128
PNG
(US9522886, 76 | US9522886, 81)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C21H22FN3O4S/c22-15-5-1-13(2-6-15)9-18-16(14-3-4-14)7-8-17(24-18)20(27)25-21(10-19(23)26)11-30(28,29)12-21/h1-2,5-8,14H,3-4,9-12H2,(H2,23,26)(H,25,27)
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n/an/an/an/a 15n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260141
PNG
(US9522886, 89)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)CCC1
Show InChI InChI=1S/C19H24FN3O4/c20-19(6-1-7-19)13-4-5-14(22-17(13)27-9-12-2-3-12)16(25)23-18(8-15(21)24)10-26-11-18/h4-5,12H,1-3,6-11H2,(H2,21,24)(H,23,25)
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n/an/an/an/a 11.9n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260060
PNG
(US9522886, 8)
Show SMILES CNC(=O)CC(CCc1ccccc1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C25H30F2N4O3/c1-28-22(32)13-19(10-9-17-5-3-2-4-6-17)29-23(33)20-11-12-21(31-15-25(26,27)16-31)24(30-20)34-14-18-7-8-18/h2-6,11-12,18-19H,7-10,13-16H2,1H3,(H,28,32)(H,29,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260074
PNG
(US9522886, 22)
Show SMILES CCOC(=O)CC(CC(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C22H32N2O4/c1-4-27-20(25)12-17(11-14(2)3)23-21(26)19-10-9-18(16-7-8-16)22(24-19)28-13-15-5-6-15/h9-10,14-17H,4-8,11-13H2,1-3H3,(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260077
PNG
(US9522886, 25)
Show SMILES CC(C)C[C@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-12(2)9-15(10-18(21)24)22-19(25)17-8-7-16(14-5-6-14)20(23-17)26-11-13-3-4-13/h7-8,12-15H,3-6,9-11H2,1-2H3,(H2,21,24)(H,22,25)/t15-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260081
PNG
(US9522886, 29)
Show SMILES CC(C)(C)[C@@H](CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-20(2,3)16(10-17(21)24)23-18(25)15-9-8-14(13-6-7-13)19(22-15)26-11-12-4-5-12/h8-9,12-13,16H,4-7,10-11H2,1-3H3,(H2,21,24)(H,23,25)/t16-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260084
PNG
((+)-5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-...)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O3/c18-17(19,20)13(7-14(21)24)23-15(25)12-6-5-11(10-3-4-10)16(22-12)26-8-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,21,24)(H,23,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260082
PNG
(US9522886, 30 | US9522886, 34)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H29N3O4/c22-19(25)11-18(15-7-9-27-10-8-15)23-20(26)17-6-5-16(14-3-4-14)21(24-17)28-12-13-1-2-13/h5-6,13-15,18H,1-4,7-12H2,(H2,22,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260091
PNG
(US9522886, 39)
Show SMILES CNC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O4/c1-21-13(24)6-16(8-26-9-16)23-14(25)12-5-4-11(17(18,19)20)15(22-12)27-7-10-2-3-10/h4-5,10H,2-3,6-9H2,1H3,(H,21,24)(H,23,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260095
PNG
(US9522886, 43)
Show SMILES NC(=O)C[C@@H](NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H24ClN3O3/c23-16-3-1-2-15(10-16)19(11-20(24)27)25-21(28)18-9-8-17(14-6-7-14)22(26-18)29-12-13-4-5-13/h1-3,8-10,13-14,19H,4-7,11-12H2,(H2,24,27)(H,25,28)/t19-/m1/s1
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260106
PNG
(US9522886, 54)
Show SMILES NC(=O)CC1(CNC(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H23F2N5O4/c20-19(21)9-26(10-19)13-4-3-12(24-17(13)30-7-11-1-2-11)16(29)25-18(5-14(22)27)6-15(28)23-8-18/h3-4,11H,1-2,5-10H2,(H2,22,27)(H,23,28)(H,25,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260105
PNG
(US9522886, 53 | US9522886, 58 | US9522886, 59)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260112
PNG
(US9522886, 60)
Show SMILES NC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O4/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)30-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-29-8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260116
PNG
(US9522886, 64)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCOC1
Show InChI InChI=1S/C20H27N3O4/c21-18(24)9-17(14-7-8-26-11-14)22-19(25)16-6-5-15(13-3-4-13)20(23-16)27-10-12-1-2-12/h5-6,12-14,17H,1-4,7-11H2,(H2,21,24)(H,22,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260119
PNG
(US9522886, 67)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOC1
Show InChI InChI=1S/C20H26F2N4O4/c21-20(22)10-26(11-20)16-4-3-14(25-19(16)30-8-12-1-2-12)18(28)24-15(7-17(23)27)13-5-6-29-9-13/h3-4,12-13,15H,1-2,5-11H2,(H2,23,27)(H,24,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260125
PNG
(US9522886, 73)
Show SMILES CC(=O)N1CC(CC(N)=O)(C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N5O4/c1-12(28)26-8-19(9-26,6-16(23)29)25-17(30)14-4-5-15(27-10-20(21,22)11-27)18(24-14)31-7-13-2-3-13/h4-5,13H,2-3,6-11H2,1H3,(H2,23,29)(H,25,30)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260126
PNG
(US9522886, 74)
Show SMILES NC(=O)CC1(CN(C1)C(=O)OCc1ccccc1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C29H29FN4O4/c30-22-10-6-19(7-11-22)14-25-23(21-8-9-21)12-13-24(32-25)27(36)33-29(15-26(31)35)17-34(18-29)28(37)38-16-20-4-2-1-3-5-20/h1-7,10-13,21H,8-9,14-18H2,(H2,31,35)(H,33,36)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260128
PNG
(US9522886, 76 | US9522886, 81)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C21H22FN3O4S/c22-15-5-1-13(2-6-15)9-18-16(14-3-4-14)7-8-17(24-18)20(27)25-21(10-19(23)26)11-30(28,29)12-21/h1-2,5-8,14H,3-4,9-12H2,(H2,23,26)(H,25,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260149
PNG
(US9522886, 97)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C16H18F3N3O3S/c17-16(18,19)10-3-4-11(21-14(10)25-6-9-1-2-9)13(24)22-15(5-12(20)23)7-26-8-15/h3-4,9H,1-2,5-8H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260055
PNG
(US9522886, 2)
Show SMILES CC(C)CC(CC(=O)OC(C)(C)C)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C24H35F2N3O4/c1-15(2)10-17(11-20(30)33-23(3,4)5)27-21(31)18-8-9-19(29-13-24(25,26)14-29)22(28-18)32-12-16-6-7-16/h8-9,15-17H,6-7,10-14H2,1-5H3,(H,27,31)
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n/an/an/an/a 676n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260064
PNG
(US9522886, 12 | US9522886, 15)
Show SMILES NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27N3O3/c21-18(24)15-3-1-2-4-16(15)22-19(25)17-10-9-14(13-7-8-13)20(23-17)26-11-12-5-6-12/h9-10,12-13,15-16H,1-8,11H2,(H2,21,24)(H,22,25)/t15-,16+/m1/s1
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n/an/an/an/a 4.90n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260079
PNG
(US9522886, 27 | US9522886, 28)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H25N3O3/c20-17(23)9-16(13-5-6-13)21-18(24)15-8-7-14(12-3-4-12)19(22-15)25-10-11-1-2-11/h7-8,11-13,16H,1-6,9-10H2,(H2,20,23)(H,21,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260094
PNG
(US9522886, 42)
Show SMILES CN(C)C(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C18H22F3N3O4/c1-24(2)14(25)7-17(9-27-10-17)23-15(26)13-6-5-12(18(19,20)21)16(22-13)28-8-11-3-4-11/h5-6,11H,3-4,7-10H2,1-2H3,(H,23,26)
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n/an/an/an/a 967n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260097
PNG
(US9522886, 45)
Show SMILES COC(=O)CC1(CCN(CC1)C(=O)OC(C)(C)C)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C26H37N3O6/c1-25(2,3)35-24(32)29-13-11-26(12-14-29,15-21(30)33-4)28-22(31)20-10-9-19(18-7-8-18)23(27-20)34-16-17-5-6-17/h9-10,17-18H,5-8,11-16H2,1-4H3,(H,28,31)
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n/an/an/an/a 237n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260105
PNG
(US9522886, 53 | US9522886, 58 | US9522886, 59)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29)
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n/an/an/an/a 55.2n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260131
PNG
(US9522886, 79)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H15ClFN3O4S/c18-11-6-10(4-5-12(11)19)13-2-1-3-14(21-13)16(24)22-17(7-15(20)23)8-27(25,26)9-17/h1-6H,7-9H2,(H2,20,23)(H,22,24)
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n/an/an/an/a 74.7n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260137
PNG
(US9522886, 85)
Show SMILES NC(=O)CC1(CCNCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H27F2N5O3/c21-20(22)11-27(12-20)15-4-3-14(25-18(15)30-10-13-1-2-13)17(29)26-19(9-16(23)28)5-7-24-8-6-19/h3-4,13,24H,1-2,5-12H2,(H2,23,28)(H,26,29)
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n/an/an/an/a 270n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260145
PNG
(US9522886, 93)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)COC1
Show InChI InChI=1S/C18H22FN3O5/c19-18(9-26-10-18)12-3-4-13(21-16(12)27-6-11-1-2-11)15(24)22-17(5-14(20)23)7-25-8-17/h3-4,11H,1-2,5-10H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260069
PNG
(US9522886, 17 | US9522886, 18)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCCCC1
Show InChI InChI=1S/C22H31N3O3/c23-20(26)12-19(16-4-2-1-3-5-16)24-21(27)18-11-10-17(15-8-9-15)22(25-18)28-13-14-6-7-14/h10-11,14-16,19H,1-9,12-13H2,(H2,23,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260090
PNG
(US9522886, 38)
Show SMILES CNC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25N3O4/c1-20-16(23)8-19(10-25-11-19)22-17(24)15-7-6-14(13-4-5-13)18(21-15)26-9-12-2-3-12/h6-7,12-13H,2-5,8-11H2,1H3,(H,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260096
PNG
(US9522886, 44)
Show SMILES CC(C)S(=O)c1nc(ccc1Br)C(=O)NC1(CC(N)=O)COC1
Show InChI InChI=1S/C14H18BrN3O4S/c1-8(2)23(21)13-9(15)3-4-10(17-13)12(20)18-14(5-11(16)19)6-22-7-14/h3-4,8H,5-7H2,1-2H3,(H2,16,19)(H,18,20)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260102
PNG
(US9522886, 50)
Show SMILES COC(=O)CC1(CNC(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H24F2N4O5/c1-30-16(28)7-19(6-15(27)23-9-19)25-17(29)13-4-5-14(26-10-20(21,22)11-26)18(24-13)31-8-12-2-3-12/h4-5,12H,2-3,6-11H2,1H3,(H,23,27)(H,25,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260128
PNG
(US9522886, 76 | US9522886, 81)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C21H22FN3O4S/c22-15-5-1-13(2-6-15)9-18-16(14-3-4-14)7-8-17(24-18)20(27)25-21(10-19(23)26)11-30(28,29)12-21/h1-2,5-8,14H,3-4,9-12H2,(H2,23,26)(H,25,27)
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n/an/an/an/a 5.50E+3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260134
PNG
(US9522886, 82)
Show SMILES NC(=O)CC1(CCOC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H24F2N4O4/c20-19(21)9-25(10-19)14-4-3-13(23-17(14)29-8-12-1-2-12)16(27)24-18(7-15(22)26)5-6-28-11-18/h3-4,12H,1-2,5-11H2,(H2,22,26)(H,24,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260150
PNG
(US9522886, 98)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)COC1
Show InChI InChI=1S/C18H22FN3O4S/c19-18(7-25-8-18)12-3-4-13(21-16(12)26-6-11-1-2-11)15(24)22-17(5-14(20)23)9-27-10-17/h3-4,11H,1-2,5-10H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260069
PNG
(US9522886, 17 | US9522886, 18)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CCCCC1
Show InChI InChI=1S/C22H31N3O3/c23-20(26)12-19(16-4-2-1-3-5-16)24-21(27)18-11-10-17(15-8-9-15)22(25-18)28-13-14-6-7-14/h10-11,14-16,19H,1-9,12-13H2,(H2,23,26)(H,24,27)
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n/an/an/an/a 6.20n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260071
PNG
(US9522886, 19)
Show SMILES CC(C)[C@H](CC(N)=O)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H26F2N4O3/c1-11(2)14(7-16(22)26)23-17(27)13-5-6-15(25-9-19(20,21)10-25)18(24-13)28-8-12-3-4-12/h5-6,11-12,14H,3-4,7-10H2,1-2H3,(H2,22,26)(H,23,27)/t14-/m0/s1
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n/an/an/an/a 3.20n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260075
PNG
(US9522886, 23)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23N3O4/c19-15(22)7-18(9-24-10-18)21-16(23)14-6-5-13(12-3-4-12)17(20-14)25-8-11-1-2-11/h5-6,11-12H,1-4,7-10H2,(H2,19,22)(H,21,23)
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n/an/an/an/a 1.40n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260079
PNG
(US9522886, 27 | US9522886, 28)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C1CC1
Show InChI InChI=1S/C19H25N3O3/c20-17(23)9-16(13-5-6-13)21-18(24)15-8-7-14(12-3-4-12)19(22-15)25-10-11-1-2-11/h7-8,11-13,16H,1-6,9-10H2,(H2,20,23)(H,21,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260112
PNG
(US9522886, 60)
Show SMILES NC(=O)CC1(CCOCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O4/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)30-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-29-8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260113
PNG
(US9522886, 61)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O5S/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)29-6-11-1-2-11)15(26)23-17(5-14(21)25)9-30(27,28)10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260114
PNG
(US9522886, 62)
Show SMILES NC(=O)CC1(CCSCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H26F2N4O3S/c21-20(22)11-26(12-20)15-4-3-14(24-18(15)29-10-13-1-2-13)17(28)25-19(9-16(23)27)5-7-30-8-6-19/h3-4,13H,1-2,5-12H2,(H2,23,27)(H,25,28)
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n/an/an/an/a 2.5n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260117
PNG
(US9522886, 65)
Show SMILES NC(=O)CC1(CNC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H23F2N5O3/c19-18(20)9-25(10-18)13-4-3-12(23-16(13)28-6-11-1-2-11)15(27)24-17(5-14(21)26)7-22-8-17/h3-4,11,22H,1-2,5-10H2,(H2,21,26)(H,24,27)
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n/an/an/an/a 443n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260120
PNG
(US9522886, 68)
Show SMILES COC(=O)CC1(CCC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N3O4/c1-28-16(26)9-19(7-2-8-19)24-17(27)14-5-6-15(25-11-20(21,22)12-25)18(23-14)29-10-13-3-4-13/h5-6,13H,2-4,7-12H2,1H3,(H,24,27)
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n/an/an/an/a 1.10n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260125
PNG
(US9522886, 73)
Show SMILES CC(=O)N1CC(CC(N)=O)(C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H25F2N5O4/c1-12(28)26-8-19(9-26,6-16(23)29)25-17(30)14-4-5-15(27-10-20(21,22)11-27)18(24-14)31-7-13-2-3-13/h4-5,13H,2-3,6-11H2,1H3,(H2,23,29)(H,25,30)
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n/an/an/an/a 120n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (human))
BDBM260128
PNG
(US9522886, 76 | US9522886, 81)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(C2CC2)c(Cc2ccc(F)cc2)n1
Show InChI InChI=1S/C21H22FN3O4S/c22-15-5-1-13(2-6-15)9-18-16(14-3-4-14)7-8-17(24-18)20(27)25-21(10-19(23)26)11-30(28,29)12-21/h1-2,5-8,14H,3-4,9-12H2,(H2,23,26)(H,25,27)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260061
PNG
(US9522886, 10 | US9522886, 9)
Show SMILES CCCCC(CC(N)=O)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C20H29N3O3/c1-2-3-4-15(11-18(21)24)22-19(25)17-10-9-16(14-7-8-14)20(23-17)26-12-13-5-6-13/h9-10,13-15H,2-8,11-12H2,1H3,(H2,21,24)(H,22,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260083
PNG
((żżż)-5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-...)
Show SMILES NC(=O)CC(NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1)C(F)(F)F
Show InChI InChI=1S/C17H20F3N3O3/c18-17(19,20)13(7-14(21)24)23-15(25)12-6-5-11(10-3-4-10)16(22-12)26-8-9-1-2-9/h5-6,9-10,13H,1-4,7-8H2,(H2,21,24)(H,23,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260098
PNG
(US9522886, 46)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(OC(F)(F)F)c(OCC2CC2)n1
Show InChI InChI=1S/C16H18F3N3O5/c17-16(18,19)27-11-4-3-10(21-14(11)26-6-9-1-2-9)13(24)22-15(5-12(20)23)7-25-8-15/h3-4,9H,1-2,5-8H2,(H2,20,23)(H,22,24)
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n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260108
PNG
(US9522886, 56)
Show SMILES OC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H21F2N3O6S/c19-18(20)7-23(8-18)13-4-3-12(21-16(13)29-6-11-1-2-11)15(26)22-17(5-14(24)25)9-30(27,28)10-17/h3-4,11H,1-2,5-10H2,(H,22,26)(H,24,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260105
PNG
(US9522886, 53 | US9522886, 58 | US9522886, 59)
Show SMILES NC(=O)CC(NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1)C1CCOCC1
Show InChI InChI=1S/C21H28F2N4O4/c22-21(23)11-27(12-21)17-4-3-15(26-20(17)31-10-13-1-2-13)19(29)25-16(9-18(24)28)14-5-7-30-8-6-14/h3-4,13-14,16H,1-2,5-12H2,(H2,24,28)(H,25,29)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260113
PNG
(US9522886, 61)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O5S/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)29-6-11-1-2-11)15(26)23-17(5-14(21)25)9-30(27,28)10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26)
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n/an/an/an/a 7.75E+3n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260131
PNG
(US9522886, 79)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1cccc(n1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H15ClFN3O4S/c18-11-6-10(4-5-12(11)19)13-2-1-3-14(21-13)16(24)22-17(7-15(20)23)8-27(25,26)9-17/h1-6H,7-9H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260136
PNG
(US9522886, 84)
Show SMILES NC(=O)CC1(CCNC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25F2N5O3/c20-19(21)10-26(11-19)14-4-3-13(24-17(14)29-8-12-1-2-12)16(28)25-18(7-15(22)27)5-6-23-9-18/h3-4,12,23H,1-2,5-11H2,(H2,22,27)(H,25,28)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260140
PNG
(US9522886, 88)
Show SMILES NC(=O)CC1(CCOC1)NC(=O)c1ccc(C2CC2)c(OCC2CC2)n1
Show InChI InChI=1S/C19H25N3O4/c20-16(23)9-19(7-8-25-11-19)22-17(24)15-6-5-14(13-3-4-13)18(21-15)26-10-12-1-2-12/h5-6,12-13H,1-4,7-11H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260141
PNG
(US9522886, 89)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)CCC1
Show InChI InChI=1S/C19H24FN3O4/c20-19(6-1-7-19)13-4-5-14(22-17(13)27-9-12-2-3-12)16(25)23-18(8-15(21)24)10-26-11-18/h4-5,12H,1-3,6-11H2,(H2,21,24)(H,23,25)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260142
PNG
(US9522886, 90)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1
Show InChI InChI=1S/C19H25N3O5/c20-15(23)8-18(10-26-11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)27-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260143
PNG
(US9522886, 91)
Show SMILES NC(=O)CC1(CSC1)NC(=O)c1ccc(N2CC(F)(F)C2)c(OCC2CC2)n1
Show InChI InChI=1S/C18H22F2N4O3S/c19-18(20)7-24(8-18)13-4-3-12(22-16(13)27-6-11-1-2-11)15(26)23-17(5-14(21)25)9-28-10-17/h3-4,11H,1-2,5-10H2,(H2,21,25)(H,23,26)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260144
PNG
(US9522886, 92)
Show SMILES NC(=O)CC1(CS(=O)(=O)C1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)CCC1
Show InChI InChI=1S/C19H25N3O6S/c20-15(23)8-18(10-29(26,27)11-18)22-16(24)14-5-4-13(19(25)6-1-7-19)17(21-14)28-9-12-2-3-12/h4-5,12,25H,1-3,6-11H2,(H2,20,23)(H,22,24)
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HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260145
PNG
(US9522886, 93)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(F)COC1
Show InChI InChI=1S/C18H22FN3O5/c19-18(9-26-10-18)12-3-4-13(21-16(12)27-6-11-1-2-11)15(24)22-17(5-14(20)23)7-25-8-17/h3-4,11H,1-2,5-10H2,(H2,20,23)(H,22,24)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (human))
BDBM260146
PNG
(US9522886, 94)
Show SMILES NC(=O)CC1(COC1)NC(=O)c1ccc(c(OCC2CC2)n1)C1(O)COC1
Show InChI InChI=1S/C18H23N3O6/c19-14(22)5-17(7-25-8-17)21-15(23)13-4-3-12(18(24)9-26-10-18)16(20-13)27-6-11-1-2-11/h3-4,11,24H,1-2,5-10H2,(H2,19,22)(H,21,23)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
CHO cells expressing human CB1 or CB2 receptors are seeded 17-24 hours prior to the experiment 50.000 cells per well in a black 96 well plate with fl...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%