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Patent code US9527839

Compile Data Set for Download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260428
PNG
(US9527839, 6)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nccc(O)n1
Show InChI InChI=1S/C29H25ClN4O5/c30-22-13-24-23(32-29(33-24)39-20-11-25(36)26(14-35)38-15-20)12-21(22)18-5-1-16(2-6-18)17-3-7-19(8-4-17)28-31-10-9-27(37)34-28/h1-10,12-13,20,25-26,35-36H,11,14-15H2,(H,32,33)(H,31,34,37)/t20-,25+,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM260438
PNG
(US9527839, 29)
Show SMILES CC(C)(O)c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F
Show InChI InChI=1S/C28H28F2N2O5/c1-28(2,35)18-9-7-16(8-10-18)15-3-5-17(6-4-15)24-20(29)12-21-26(25(24)30)32-27(31-21)37-19-11-22(34)23(13-33)36-14-19/h3-10,12,19,22-23,33-35H,11,13-14H2,1-2H3,(H,31,32)/t19-,22+,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260447
PNG
(US9527839, 45)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cncn1
Show InChI InChI=1S/C27H23F2N5O4/c28-20-10-21-26(33-27(32-21)38-19-9-22(36)23(11-35)37-12-19)25(29)24(20)17-3-1-15(2-4-17)16-5-7-18(8-6-16)34-14-30-13-31-34/h1-8,10,13-14,19,22-23,35-36H,9,11-12H2,(H,32,33)/t19-,22+,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM260437
PNG
(US9527839, 26)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F
Show InChI InChI=1S/C26H24F2N2O6S/c1-37(33,34)18-8-6-15(7-9-18)14-2-4-16(5-3-14)23-19(27)11-20-25(24(23)28)30-26(29-20)36-17-10-21(32)22(12-31)35-13-17/h2-9,11,17,21-22,31-32H,10,12-13H2,1H3,(H,29,30)/t17-,21+,22-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260429
PNG
(US9527839, 7)
Show SMILES CC(CO)(CO)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@H]3CO[C@H](CO)[C@@H](O)C3)[nH]c2cc1Cl
Show InChI InChI=1S/C29H31ClN2O6/c1-29(15-34,16-35)20-8-6-18(7-9-20)17-2-4-19(5-3-17)22-11-24-25(12-23(22)30)32-28(31-24)38-21-10-26(36)27(13-33)37-14-21/h2-9,11-12,21,26-27,33-36H,10,13-16H2,1H3,(H,31,32)/t21-,26+,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260442
PNG
(US9527839, 39)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nccs1
Show InChI InChI=1S/C28H23F2N3O4S/c29-20-12-21-26(33-28(32-21)37-19-11-22(35)23(13-34)36-14-19)25(30)24(20)17-5-1-15(2-6-17)16-3-7-18(8-4-16)27-31-9-10-38-27/h1-10,12,19,22-23,34-35H,11,13-14H2,(H,32,33)/t19-,22+,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260443
PNG
(US9527839, 40)
Show SMILES Nc1nc(=N)n([nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F
Show InChI InChI=1S/C27H25F2N7O4/c28-18-10-19-24(33-27(32-19)40-17-9-20(38)21(11-37)39-12-17)23(29)22(18)15-3-1-13(2-4-15)14-5-7-16(8-6-14)36-26(31)34-25(30)35-36/h1-8,10,17,20-21,37-38H,9,11-12H2,(H,32,33)(H4,30,31,34,35)/t17-,20+,21-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260444
PNG
(US9527839, 42)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C1CCNCC1
Show InChI InChI=1S/C30H31F2N3O6S/c31-23-14-24-29(35-30(34-24)41-20-13-25(37)26(15-36)40-16-20)28(32)27(23)19-3-1-17(2-4-19)18-5-7-21(8-6-18)42(38,39)22-9-11-33-12-10-22/h1-8,14,20,22,25-26,33,36-37H,9-13,15-16H2,(H,34,35)/t20-,25+,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260445
PNG
(US9527839, 43)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CCNC1=O
Show InChI InChI=1S/C29H27F2N3O5/c30-21-12-22-27(34-29(33-22)39-19-11-23(36)24(13-35)38-14-19)26(31)25(21)18-7-3-16(4-8-18)15-1-5-17(6-2-15)20-9-10-32-28(20)37/h1-8,12,19-20,23-24,35-36H,9-11,13-14H2,(H,32,37)(H,33,34)/t19-,20?,23+,24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260451
PNG
(US9527839, 50)
Show SMILES CC(C)(O)Cc1cnn(c1)-c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F
Show InChI InChI=1S/C32H32F2N4O5/c1-32(2,41)13-18-14-35-38(15-18)22-9-7-20(8-10-22)19-3-5-21(6-4-19)28-24(33)12-25-30(29(28)34)37-31(36-25)43-23-11-26(40)27(16-39)42-17-23/h3-10,12,14-15,23,26-27,39-41H,11,13,16-17H2,1-2H3,(H,36,37)/t23-,26+,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260431
PNG
(US9527839, 16)
Show SMILES Nc1nc(=N)n([nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@H]3CO[C@H](CO)[C@@H](O)C3)[nH]c2cc1Cl
Show InChI InChI=1S/C27H26ClN7O4/c28-20-11-22-21(31-27(32-22)39-18-9-23(37)24(12-36)38-13-18)10-19(20)16-3-1-14(2-4-16)15-5-7-17(8-6-15)35-26(30)33-25(29)34-35/h1-8,10-11,18,23-24,36-37H,9,12-13H2,(H,31,32)(H4,29,30,33,34)/t18-,23+,24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260430
PNG
(US9527839, 8)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CNCCO1
Show InChI InChI=1S/C29H30ClN3O5/c30-23-13-25-24(32-29(33-25)38-21-11-26(35)28(15-34)37-16-21)12-22(23)19-5-1-17(2-6-19)18-3-7-20(8-4-18)27-14-31-9-10-36-27/h1-8,12-13,21,26-28,31,34-35H,9-11,14-16H2,(H,32,33)/t21-,26+,27?,28-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260434
PNG
(US9527839, 21)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cncn1
Show InChI InChI=1S/C27H24ClN5O4/c28-22-11-24-23(31-27(32-24)37-20-9-25(35)26(12-34)36-13-20)10-21(22)18-3-1-16(2-4-18)17-5-7-19(8-6-17)33-15-29-14-30-33/h1-8,10-11,14-15,20,25-26,34-35H,9,12-13H2,(H,31,32)/t20-,25+,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260439
PNG
(US9527839, 35)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nccc(O)n1
Show InChI InChI=1S/C29H24F2N4O5/c30-20-12-21-27(35-29(33-21)40-19-11-22(37)23(13-36)39-14-19)26(31)25(20)17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-32-10-9-24(38)34-28/h1-10,12,19,22-23,36-37H,11,13-14H2,(H,33,35)(H,32,34,38)/t19-,22+,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260446
PNG
(US9527839, 44)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(CCCC(O)=O)cc1
Show InChI InChI=1S/C29H28F2N2O6/c30-21-13-22-28(33-29(32-22)39-20-12-23(35)24(14-34)38-15-20)27(31)26(21)19-10-8-18(9-11-19)17-6-4-16(5-7-17)2-1-3-25(36)37/h4-11,13,20,23-24,34-35H,1-3,12,14-15H2,(H,32,33)(H,36,37)/t20-,23+,24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260449
PNG
(US9527839, 48)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F
Show InChI InChI=1S/C27H25F2N3O5/c1-30-26(35)17-8-4-15(5-9-17)14-2-6-16(7-3-14)23-19(28)11-20-25(24(23)29)32-27(31-20)37-18-10-21(34)22(12-33)36-13-18/h2-9,11,18,21-22,33-34H,10,12-13H2,1H3,(H,30,35)(H,31,32)/t18-,21+,22-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1


(Homo sapiens-Homo sapiens (Human))
BDBM260427
PNG
(US9527839, 2)
Show SMILES CS(=O)(=O)Cc1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@H]3CO[C@H](CO)[C@@H](O)C3)[nH]c2cc1Cl
Show InChI InChI=1S/C27H27ClN2O6S/c1-37(33,34)15-16-2-4-17(5-3-16)18-6-8-19(9-7-18)21-11-23-24(12-22(21)28)30-27(29-23)36-20-10-25(32)26(13-31)35-14-20/h2-9,11-12,20,25-26,31-32H,10,13-15H2,1H3,(H,29,30)/t20-,25+,26-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260440
PNG
(US9527839, 36)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CNCCO1
Show InChI InChI=1S/C29H29F2N3O5/c30-21-12-22-28(34-29(33-22)39-20-11-23(36)25(14-35)38-15-20)27(31)26(21)19-7-3-17(4-8-19)16-1-5-18(6-2-16)24-13-32-9-10-37-24/h1-8,12,20,23-25,32,35-36H,9-11,13-15H2,(H,33,34)/t20-,23+,24?,25-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260448
PNG
(US9527839, 47)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nnc(O)o1
Show InChI InChI=1S/C27H22F2N4O6/c28-18-10-19-24(31-26(30-19)38-17-9-20(35)21(11-34)37-12-17)23(29)22(18)15-5-1-13(2-6-15)14-3-7-16(8-4-14)25-32-33-27(36)39-25/h1-8,10,17,20-21,34-35H,9,11-12H2,(H,30,31)(H,33,36)/t17-,20+,21-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260432
PNG
(US9527839, 18)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C1CCNCC1
Show InChI InChI=1S/C30H32ClN3O6S/c31-25-15-27-26(33-30(34-27)40-21-13-28(36)29(16-35)39-17-21)14-24(25)20-3-1-18(2-4-20)19-5-7-22(8-6-19)41(37,38)23-9-11-32-12-10-23/h1-8,14-15,21,23,28-29,32,35-36H,9-13,16-17H2,(H,33,34)/t21-,28+,29-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


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Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260436
PNG
(US9527839, 24)
Show SMILES CC(C)(O)Cc1cnn(c1)-c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@H]3CO[C@H](CO)[C@@H](O)C3)[nH]c2cc1Cl
Show InChI InChI=1S/C32H33ClN4O5/c1-32(2,40)14-19-15-34-37(16-19)23-9-7-21(8-10-23)20-3-5-22(6-4-20)25-12-27-28(13-26(25)33)36-31(35-27)42-24-11-29(39)30(17-38)41-18-24/h3-10,12-13,15-16,24,29-30,38-40H,11,14,17-18H2,1-2H3,(H,35,36)/t24-,29+,30-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260435
PNG
(US9527839, 23)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C26H21ClN6O4/c27-20-11-22-21(28-26(29-22)37-18-9-23(35)24(12-34)36-13-18)10-19(20)16-5-1-14(2-6-16)15-3-7-17(8-4-15)25-30-32-33-31-25/h1-8,10-11,18,23-24,34-35H,9,12-13H2/t18-,23+,24-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260441
PNG
(US9527839, 38)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1ncco1
Show InChI InChI=1S/C28H23F2N3O5/c29-20-12-21-26(33-28(32-21)38-19-11-22(35)23(13-34)37-14-19)25(30)24(20)17-5-1-15(2-6-17)16-3-7-18(8-4-16)27-31-9-10-36-27/h1-10,12,19,22-23,34-35H,11,13-14H2,(H,32,33)/t19-,22+,23-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260450
PNG
(US9527839, 49)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C26H20F2N6O4/c27-18-10-19-24(30-26(29-19)38-17-9-20(36)21(11-35)37-12-17)23(28)22(18)15-5-1-13(2-6-15)14-3-7-16(8-4-14)25-31-33-34-32-25/h1-8,10,17,20-21,35-36H,9,11-12H2/t17-,20+,21-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
AMPK alpha2/beta1/gamma1


(Homo sapiens (Human))
BDBM260433
PNG
(US9527839, 19)
Show SMILES OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CCNC1=O
Show InChI InChI=1S/C29H28ClN3O5/c30-23-13-25-24(32-29(33-25)38-20-11-26(35)27(14-34)37-15-20)12-22(23)19-7-3-17(4-8-19)16-1-5-18(6-2-16)21-9-10-31-28(21)36/h1-8,12-13,20-21,26-27,34-35H,9-11,14-15H2,(H,31,36)(H,32,33)/t20-,21?,26+,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The in vitro AMPK activation assay is performed in a volume of 30 ul in a 384-well plate. Enzyme reactions were assembled in the microtiter plate by ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%