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Patent code US9527851

Compile Data Set for Download or QSAR

Found 260 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US9527851, 125 | US9527851, 49 | US9527851, exampl...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29)/t12-,13+,14+
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n/an/a 0.200n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US9527851, 125 | US9527851, 49 | US9527851, exampl...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29)/t12-,13+,14+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260459
PNG
(US9527851, 17 | US9527851, example 17)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20)/t10-,11-,12+,13+/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US9527851, 125 | US9527851, 49 | US9527851, exampl...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29)/t12-,13+,14+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260459
PNG
(US9527851, 17 | US9527851, example 17)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20)/t10-,11-,12+,13+/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260478
PNG
(US9527851, 125 | US9527851, 49 | US9527851, exampl...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29)/t12-,13+,14+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202489
PNG
(US9527851, example 99)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Oc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H27N7O4S/c1-21(2,30)10-31-18-25-19(33-26-18)32-20(29)28-8-12-6-14(7-13(12)9-28)27(3)17-15-4-5-22-16(15)23-11-24-17/h4-5,11-14,30H,6-10H2,1-3H3,(H,22,23,24)/t12-,13+,14+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260459
PNG
(US9527851, 17 | US9527851, example 17)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20)/t10-,11-,12+,13+/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260502
PNG
(US9527851, 99)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H28N8O3S/c1-21(2,31)10-32-18-25-19(33-27-18)26-20(30)29-8-12-6-14(7-13(12)9-29)28(3)17-15-4-5-22-16(15)23-11-24-17/h4-5,11-14,31H,6-10H2,1-3H3,(H,22,23,24)(H,25,26,27,30)/t12-,13+,14?
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260459
PNG
(US9527851, 17 | US9527851, example 17)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20)/t10-,11-,12+,13+/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260479
PNG
(US9527851, 50)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N8O2S/c1-25(16-13-2-3-19-15(13)20-9-21-16)12-4-10-6-26(7-11(10)5-12)18(28)23-17-22-14(8-27)24-29-17/h2-3,9-12,27H,4-8H2,1H3,(H,19,20,21)(H,22,23,24,28)/t10-,11+,12?
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202338
PNG
((3ar,5s,6as)-n-(3-(hydroxymethyl)-1,2,4-thiadiazol...)
Show SMILES COC(=O)c1nsc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H22N8O3S/c1-26(16-13-3-4-20-14(13)21-9-22-16)12-5-10-7-27(8-11(10)6-12)19(29)24-18-23-15(25-31-18)17(28)30-2/h3-4,9-12H,5-8H2,1-2H3,(H,20,21,22)(H,23,24,25,29)/t10-,11+,12?
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US9527851, 147 | US9527851, 40 | US9527851, exampl...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19)/t9-,10+,11-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US9527851, 121 | US9527851, 48 | US9527851, exampl...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H24N8OS/c1-3-15-23-18(29-25-15)24-19(28)27-8-11-6-13(7-12(11)9-27)26(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28)/t11-,12+,13+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US9527851, 121 | US9527851, 48 | US9527851, exampl...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H24N8OS/c1-3-15-23-18(29-25-15)24-19(28)27-8-11-6-13(7-12(11)9-27)26(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28)/t11-,12+,13+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202503
PNG
(US9527851, example 121)
Show SMILES CCc1nsc(OC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H23N7O2S/c1-3-15-23-18(29-24-15)28-19(27)26-8-11-6-13(7-12(11)9-26)25(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)/t11-,12+,13+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260477
PNG
(US9527851, 121 | US9527851, 48 | US9527851, exampl...)
Show SMILES CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H24N8OS/c1-3-15-23-18(29-25-15)24-19(28)27-8-11-6-13(7-12(11)9-27)26(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28)/t11-,12+,13+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260475
PNG
(US9527851, 147 | US9527851, 40 | US9527851, exampl...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19)/t9-,10+,11-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260508
PNG
(US9527851, 114 | US9527851, example 114)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H23N7OS/c1-11-22-18(28-24-11)23-19(27)26-9-12-7-14(8-13(12)10-26)25(2)16-4-6-21-17-15(16)3-5-20-17/h3-6,12-14H,7-10H2,1-2H3,(H,20,21)(H,22,23,24,27)/t12-,13+,14+
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n/an/a 2n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260508
PNG
(US9527851, 114 | US9527851, example 114)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H23N7OS/c1-11-22-18(28-24-11)23-19(27)26-9-12-7-14(8-13(12)10-26)25(2)16-4-6-21-17-15(16)3-5-20-17/h3-6,12-14H,7-10H2,1-2H3,(H,20,21)(H,22,23,24,27)/t12-,13+,14+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260469
PNG
(US9527851, 34 | US9527851, example 34)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27)/t10-,11+,12+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260469
PNG
(US9527851, 34 | US9527851, example 34)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27)/t10-,11+,12+
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US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260518
PNG
(US9527851, 135 | US9527851, example 135)
Show SMILES CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)C1CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H21N5O/c1-21(16-11-4-5-18-15(11)19-9-20-16)6-12-13-7-22(8-14(12)13)17(23)10-2-3-10/h4-5,9-10,12-14H,2-3,6-8H2,1H3,(H,18,19,20)/t12-,13-,14+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260518
PNG
(US9527851, 135 | US9527851, example 135)
Show SMILES CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)C1CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H21N5O/c1-21(16-11-4-5-18-15(11)19-9-20-16)6-12-13-7-22(8-14(12)13)17(23)10-2-3-10/h4-5,9-10,12-14H,2-3,6-8H2,1H3,(H,18,19,20)/t12-,13-,14+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202320
PNG
(1-((4as,7ar)-6-(methyl(7h-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES CN(Cc1ccccc1)C1C[C@H]2CCN(C[C@H]2C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H32N2O2/c1-21(2,3)25-20(24)23-11-10-17-12-19(13-18(17)15-23)22(4)14-16-8-6-5-7-9-16/h5-9,17-19H,10-15H2,1-4H3/t17-,18-,19?/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260470
PNG
(US9527851, 35)
Show SMILES CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(C)=O)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O/c1-11(23)22-6-4-12-7-14(8-13(12)9-22)21(2)17-15-3-5-18-16(15)19-10-20-17/h3,5,10,12-14H,4,6-9H2,1-2H3,(H,18,19,20)/t12-,13-,14?/m0/s1
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US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260459
PNG
(US9527851, 17 | US9527851, example 17)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20)/t10-,11-,12+,13+/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260459
PNG
(US9527851, 17 | US9527851, example 17)
Show SMILES C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20)/t10-,11-,12+,13+/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260485
PNG
(US9527851, 69 | US9527851, example 69)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20)/t11-,12+,13-
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260485
PNG
(US9527851, 69 | US9527851, example 69)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20)/t11-,12+,13-
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260489
PNG
(US9527851, 74 | US9527851, example 74)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27)/t10-,11+,12-
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US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260523
PNG
(US9527851, 155 | US9527851, example 155)
Show SMILES COc1nnc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)17(27)22-16-23-24-18(28-2)29-16/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,27)/t10-,11+,12?
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US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260514
PNG
(US9527851, 128 | US9527851, example 128)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12
Show InChI InChI=1S/C16H20FN5O2/c1-21(16-14-12(17)4-18-15(14)19-8-20-16)11-2-9-5-22(13(24)7-23)6-10(9)3-11/h4,8-11,23H,2-3,5-7H2,1H3,(H,18,19,20)/t9-,10+,11?
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM260514
PNG
(US9527851, 128 | US9527851, example 128)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12
Show InChI InChI=1S/C16H20FN5O2/c1-21(16-14-12(17)4-18-15(14)19-8-20-16)11-2-9-5-22(13(24)7-23)6-10(9)3-11/h4,8-11,23H,2-3,5-7H2,1H3,(H,18,19,20)/t9-,10+,11?
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US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260489
PNG
(US9527851, 74 | US9527851, example 74)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27)/t10-,11+,12-
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US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260523
PNG
(US9527851, 155 | US9527851, example 155)
Show SMILES COc1nnc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)17(27)22-16-23-24-18(28-2)29-16/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,27)/t10-,11+,12?
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM202489
PNG
(US9527851, example 99)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Oc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H27N7O4S/c1-21(2,30)10-31-18-25-19(33-26-18)32-20(29)28-8-12-6-14(7-13(12)9-28)27(3)17-15-4-5-22-16(15)23-11-24-17/h4-5,11-14,30H,6-10H2,1-3H3,(H,22,23,24)/t12-,13+,14+
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Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260469
PNG
(US9527851, 34 | US9527851, example 34)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27)/t10-,11+,12+
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Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260475
PNG
(US9527851, 147 | US9527851, 40 | US9527851, exampl...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19)/t9-,10+,11-/m1/s1
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Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260502
PNG
(US9527851, 99)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H28N8O3S/c1-21(2,31)10-32-18-25-19(33-27-18)26-20(30)29-8-12-6-14(7-13(12)9-29)28(3)17-15-4-5-22-16(15)23-11-24-17/h4-5,11-14,31H,6-10H2,1-3H3,(H,22,23,24)(H,25,26,27,30)/t12-,13+,14?
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n/an/a 5n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260453
PNG
(US9527851, 6 | US9527851, example 112)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H21N5O2/c1-20(16-13-2-3-17-15(13)18-9-19-16)12-4-10-6-21(14(23)8-22)7-11(10)5-12/h2-3,9-12,22H,4-8H2,1H3,(H,17,18,19)/t10-,11+,12+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260469
PNG
(US9527851, 34 | US9527851, example 34)
Show SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27)/t10-,11+,12+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM202291
PNG
(2-hydroxy-1-((3ar,5s,6as)-5-(methyl(7h-pyrrolo[2,3...)
Show SMILES CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OO)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H19N5O3/c1-19(14-12-2-3-16-13(12)17-8-18-14)11-4-9-6-20(15(21)23-22)7-10(9)5-11/h2-3,8-11,22H,4-7H2,1H3,(H,16,17,18)/t9-,10+,11+
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260475
PNG
(US9527851, 147 | US9527851, 40 | US9527851, exampl...)
Show SMILES CN([C@H]1C[C@H]2CNC(=O)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19)/t9-,10+,11-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260485
PNG
(US9527851, 69 | US9527851, example 69)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20)/t11-,12+,13-
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM260485
PNG
(US9527851, 69 | US9527851, example 69)
Show SMILES CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20)/t11-,12+,13-
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260473
PNG
(US9527851, 38 | US9527851, example 38)
Show SMILES COc1nsc(NC(=O)N2CC[C@H]3CC(C[C@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H24N8O2S/c1-26(16-14-3-5-20-15(14)21-10-22-16)13-7-11-4-6-27(9-12(11)8-13)19(28)24-18-23-17(29-2)25-30-18/h3,5,10-13H,4,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28)/t11-,12-,13?/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM202338
PNG
((3ar,5s,6as)-n-(3-(hydroxymethyl)-1,2,4-thiadiazol...)
Show SMILES COC(=O)c1nsc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H22N8O3S/c1-26(16-13-3-4-20-14(13)21-9-22-16)12-5-10-7-27(8-11(10)6-12)19(29)24-18-23-15(25-31-18)17(28)30-2/h3-4,9-12H,5-8H2,1-2H3,(H,20,21,22)(H,23,24,25,29)/t10-,11+,12?
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260473
PNG
(US9527851, 38 | US9527851, example 38)
Show SMILES COc1nsc(NC(=O)N2CC[C@H]3CC(C[C@H]3C2)N(C)c2ncnc3[nH]ccc23)n1
Show InChI InChI=1S/C19H24N8O2S/c1-26(16-14-3-5-20-15(14)21-10-22-16)13-7-11-4-6-27(9-12(11)8-13)19(28)24-18-23-17(29-2)25-30-18/h3,5,10-13H,4,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28)/t11-,12-,13?/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM260479
PNG
(US9527851, 50)
Show SMILES CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H22N8O2S/c1-25(16-13-2-3-19-15(13)20-9-21-16)12-4-10-6-26(7-11(10)5-12)18(28)23-17-22-14(8-27)24-29-17/h2-3,9-12,27H,4-8H2,1H3,(H,19,20,21)(H,22,23,24,28)/t10-,11+,12?
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Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.

US Patent


Assay Description
In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...


Citation and Details
More data for this
Ligand-Target Pair
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