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Patent code US9532990

Compile Data Set for Download or QSAR
Found 119 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260571
PNG
(US9532990, 45 | US9717745, 3)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H17F5N6O2/c1-2-17(36)34-6-5-11(9-34)35-24-18(23(30)31-10-32-24)21(33-35)13-4-3-12(7-14(13)25)37-22-19(28)15(26)8-16(27)20(22)29/h2-4,7-8,10-11H,1,5-6,9H2,(H2,30,31,32)/t11-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260587
PNG
(US9532990, 61)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)CCl
Show InChI InChI=1S/C24H18ClF5N6O2/c25-8-17(37)35-5-1-2-11(9-35)36-24-18(23(31)32-10-33-24)21(34-36)13-4-3-12(6-14(13)26)38-22-19(29)15(27)7-16(28)20(22)30/h3-4,6-7,10-11H,1-2,5,8-9H2,(H2,31,32,33)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260537
PNG
(US9532990, 11)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3c(F)c(F)cc(F)c3F)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H19F5N6O2/c1-2-18(38)36-7-3-4-13(10-36)37-26-20(25(32)33-11-34-26)23(35-37)14-6-5-12(8-15(14)27)24(39)19-21(30)16(28)9-17(29)22(19)31/h2,5-6,8-9,11,13H,1,3-4,7,10H2,(H2,32,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260642
PNG
(US9532990, 116)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)S(=O)(=O)C=C
Show InChI InChI=1S/C23H17F5N6O3S/c1-2-38(35,36)33-6-5-11(9-33)34-23-17(22(29)30-10-31-23)20(32-34)13-4-3-12(7-14(13)24)37-21-18(27)15(25)8-16(26)19(21)28/h2-4,7-8,10-11H,1,5-6,9H2,(H2,29,30,31)/t11-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260598
PNG
(US9532990, 72)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3ccccc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H20F2N6O2/c1-2-20(34)32-10-9-15(12-32)33-25-21(24(28)29-13-30-25)22(31-33)16-8-7-14(11-19(16)27)23(35)17-5-3-4-6-18(17)26/h2-8,11,13,15H,1,9-10,12H2,(H2,28,29,30)/t15-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260620
PNG
(US9532990, 94 | US9717745, 5)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H20F2N6O2/c1-2-20(33)31-9-8-15(12-31)32-24-21(23(27)28-13-29-24)22(30-32)18-7-6-17(11-19(18)26)34-16-5-3-4-14(25)10-16/h2-7,10-11,13,15H,1,8-9,12H2,(H2,27,28,29)/t15-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260539
PNG
(US9532990, 13)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)[C@@H]1CC[C@@H](CC1)NC(=O)C=C
Show InChI InChI=1S/C26H24F2N6O2/c1-2-22(35)32-16-6-8-17(9-7-16)34-26-23(25(29)30-14-31-26)24(33-34)20-11-10-19(13-21(20)28)36-18-5-3-4-15(27)12-18/h2-5,10-14,16-17H,1,6-9H2,(H,32,35)(H2,29,30,31)/t16-,17+
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260625
PNG
(US9532990, 99)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCCN(C1)C(=O)CCl
Show InChI InChI=1S/C24H18ClF5N6O2/c25-8-17(37)35-5-1-2-11(9-35)36-24-18(23(31)32-10-33-24)21(34-36)13-4-3-12(6-14(13)26)38-22-19(29)15(27)7-16(28)20(22)30/h3-4,6-7,10-11H,1-2,5,8-9H2,(H2,31,32,33)/t11-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260531
PNG
(US9532990, 5)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3cccc(F)c3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H22F2N6O2/c1-2-21(35)33-10-4-7-18(13-33)34-26-22(25(29)30-14-31-26)23(32-34)19-9-8-16(12-20(19)28)24(36)15-5-3-6-17(27)11-15/h2-3,5-6,8-9,11-12,14,18H,1,4,7,10,13H2,(H2,29,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260626
PNG
(US9532990, 100)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CCCN(C1)C(=O)CCl
Show InChI InChI=1S/C24H18ClF5N6O2/c25-8-17(37)35-5-1-2-11(9-35)36-24-18(23(31)32-10-33-24)21(34-36)13-4-3-12(6-14(13)26)38-22-19(29)15(27)7-16(28)20(22)30/h3-4,6-7,10-11H,1-2,5,8-9H2,(H2,31,32,33)/t11-/m0/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260530
PNG
(US9532990, 4)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3ccccc3F)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H22F2N6O2/c1-2-21(35)33-11-5-6-16(13-33)34-26-22(25(29)30-14-31-26)23(32-34)17-10-9-15(12-20(17)28)24(36)18-7-3-4-8-19(18)27/h2-4,7-10,12,14,16H,1,5-6,11,13H2,(H2,29,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260559
PNG
(US9532990, 33 | US9717745, 1)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)35-7-3-4-12(10-35)36-25-19(24(31)32-11-33-25)22(34-36)14-6-5-13(8-15(14)26)38-23-20(29)16(27)9-17(28)21(23)30/h2,5-6,8-9,11-12H,1,3-4,7,10H2,(H2,31,32,33)/t12-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260534
PNG
(US9532990, 8)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3cccc(F)c3)c12)C1CCCN(C1)S(=O)(=O)C=C
Show InChI InChI=1S/C25H22F2N6O3S/c1-2-37(35,36)32-10-4-7-18(13-32)33-25-21(24(28)29-14-30-25)22(31-33)19-9-8-16(12-20(19)27)23(34)15-5-3-6-17(26)11-15/h2-3,5-6,8-9,11-12,14,18H,1,4,7,10,13H2,(H2,28,29,30)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260624
PNG
(US9532990, 98)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)\C=C/C#N
Show InChI InChI=1S/C25H16F5N7O2/c26-15-8-13(39-23-20(29)16(27)9-17(28)21(23)30)3-4-14(15)22-19-24(32)33-11-34-25(19)37(35-22)12-5-7-36(10-12)18(38)2-1-6-31/h1-4,8-9,11-12H,5,7,10H2,(H2,32,33,34)/b2-1-/t12-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260538
PNG
(US9532990, 12)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4[N+]([O-])=O)cc3F)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H21F2N7O4/c1-2-20(35)32-10-4-5-14(12-32)33-25-21(24(28)29-13-30-25)22(31-33)16-9-8-15(11-18(16)27)38-19-7-3-6-17(26)23(19)34(36)37/h2-3,6-9,11,13-14H,1,4-5,10,12H2,(H2,28,29,30)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260544
PNG
(US9532990, 18)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H22F2N6O2/c1-2-21(34)32-10-4-6-16(13-32)33-25-22(24(28)29-14-30-25)23(31-33)19-9-8-18(12-20(19)27)35-17-7-3-5-15(26)11-17/h2-3,5,7-9,11-12,14,16H,1,4,6,10,13H2,(H2,28,29,30)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260617
PNG
(US9532990, 91)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C27H24F5N7O2/c1-37(2)8-3-4-20(40)38-9-7-14(12-38)39-27-21(26(33)34-13-35-27)24(36-39)16-6-5-15(10-17(16)28)41-25-22(31)18(29)11-19(30)23(25)32/h3-6,10-11,13-14H,7-9,12H2,1-2H3,(H2,33,34,35)/b4-3+/t14-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260601
PNG
(US9532990, 75)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)CCl
Show InChI InChI=1S/C23H16ClF5N6O2/c24-7-16(36)34-4-3-10(8-34)35-23-17(22(30)31-9-32-23)20(33-35)12-2-1-11(5-13(12)25)37-21-18(28)14(26)6-15(27)19(21)29/h1-2,5-6,9-10H,3-4,7-8H2,(H2,30,31,32)/t10-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260542
PNG
(US9532990, 16)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)[C@@H]1CC[C@H](C1)NC(=O)C=C
Show InChI InChI=1S/C25H22F2N6O2/c1-2-21(34)31-15-6-7-16(11-15)33-25-22(24(28)29-13-30-25)23(32-33)19-9-8-18(12-20(19)27)35-17-5-3-4-14(26)10-17/h2-5,8-10,12-13,15-16H,1,6-7,11H2,(H,31,34)(H2,28,29,30)/t15-,16-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260541
PNG
(US9532990, 15)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H20F2N6O2/c1-2-20(33)31-9-8-15(12-31)32-24-21(23(27)28-13-29-24)22(30-32)18-7-6-17(11-19(18)26)34-16-5-3-4-14(25)10-16/h2-7,10-11,13,15H,1,8-9,12H2,(H2,27,28,29)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260600
PNG
(US9532990, 74)
Show SMILES CCOC(=O)\C=C\CNC(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C29H26F5N7O4/c1-2-44-21(42)6-3-9-36-29(43)40-10-4-5-15(13-40)41-28-22(27(35)37-14-38-28)25(39-41)17-8-7-16(11-18(17)30)45-26-23(33)19(31)12-20(32)24(26)34/h3,6-8,11-12,14-15H,2,4-5,9-10,13H2,1H3,(H,36,43)(H2,35,37,38)/b6-3+
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260632
PNG
(US9532990, 106)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C(F)=C
Show InChI InChI=1S/C24H16F6N6O2/c1-10(25)24(37)35-5-4-11(8-35)36-23-17(22(31)32-9-33-23)20(34-36)13-3-2-12(6-14(13)26)38-21-18(29)15(27)7-16(28)19(21)30/h2-3,6-7,9,11H,1,4-5,8H2,(H2,31,32,33)/t11-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260549
PNG
(US9532990, 23)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H17F5N6O2/c1-2-17(36)34-6-5-11(9-34)35-24-18(23(30)31-10-32-24)21(33-35)13-4-3-12(7-14(13)25)37-22-19(28)15(26)8-16(27)20(22)29/h2-4,7-8,10-11H,1,5-6,9H2,(H2,30,31,32)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260543
PNG
(US9532990, 17)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)[C@@H]1CC[C@@H](C1)NC(=O)C=C
Show InChI InChI=1S/C25H22F2N6O2/c1-2-21(34)31-15-6-7-16(11-15)33-25-22(24(28)29-13-30-25)23(32-33)19-9-8-18(12-20(19)27)35-17-5-3-4-14(26)10-17/h2-5,8-10,12-13,15-16H,1,6-7,11H2,(H,31,34)(H2,28,29,30)/t15-,16+/m0/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260546
PNG
(US9532990, 20)
Show SMILES CS(=O)(=O)Nc1cccc(Oc2ccc(-c3nn(C4CCCN(C4)C(=O)C=C)c4ncnc(N)c34)c(F)c2)c1
Show InChI InChI=1S/C26H26FN7O4S/c1-3-22(35)33-11-5-7-17(14-33)34-26-23(25(28)29-15-30-26)24(31-34)20-10-9-19(13-21(20)27)38-18-8-4-6-16(12-18)32-39(2,36)37/h3-4,6,8-10,12-13,15,17,32H,1,5,7,11,14H2,2H3,(H2,28,29,30)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260621
PNG
(US9532990, 95)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ncccn4)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C22H19FN8O2/c1-2-17(32)30-9-6-13(11-30)31-21-18(20(24)27-12-28-21)19(29-31)15-5-4-14(10-16(15)23)33-22-25-7-3-8-26-22/h2-5,7-8,10,12-13H,1,6,9,11H2,(H2,24,27,28)/t13-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260547
PNG
(US9532990, 21)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)ccc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H20F4N6O2/c1-2-19(36)34-9-3-4-13(11-34)35-25-20(24(30)31-12-32-25)22(33-35)15-6-5-14(10-18(15)28)37-23-17(27)8-7-16(26)21(23)29/h2,5-8,10,12-13H,1,3-4,9,11H2,(H2,30,31,32)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260528
PNG
(US9532990, 2)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3ccc(F)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H22F2N6O2/c1-2-21(35)33-11-3-4-18(13-33)34-26-22(25(29)30-14-31-26)23(32-34)19-10-7-16(12-20(19)28)24(36)15-5-8-17(27)9-6-15/h2,5-10,12,14,18H,1,3-4,11,13H2,(H2,29,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260623
PNG
(US9532990, 97)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4nccc(n4)C(F)(F)F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H18F4N8O2/c1-2-17(36)34-8-6-12(10-34)35-21-18(20(28)30-11-31-21)19(33-35)14-4-3-13(9-15(14)24)37-22-29-7-5-16(32-22)23(25,26)27/h2-5,7,9,11-12H,1,6,8,10H2,(H2,28,30,31)/t12-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260573
PNG
(US9532990, 47)
Show SMILES COC(=O)NC(=O)\C=C/C(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C28H22F5N7O5/c1-44-28(43)37-19(41)6-7-20(42)39-8-2-3-13(11-39)40-27-21(26(34)35-12-36-27)24(38-40)15-5-4-14(9-16(15)29)45-25-22(32)17(30)10-18(31)23(25)33/h4-7,9-10,12-13H,2-3,8,11H2,1H3,(H2,34,35,36)(H,37,41,43)/b7-6-
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260597
PNG
(US9532990, 71)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3ccc(F)cc3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H20F2N6O2/c1-2-20(34)32-10-9-17(12-32)33-25-21(24(28)29-13-30-25)22(31-33)18-8-5-15(11-19(18)27)23(35)14-3-6-16(26)7-4-14/h2-8,11,13,17H,1,9-10,12H2,(H2,28,29,30)/t17-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260590
PNG
(US9532990, 64)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)C(=C)C(F)(F)F
Show InChI InChI=1S/C26H18F8N6O2/c1-11(26(32,33)34)25(41)39-6-2-3-12(9-39)40-24-18(23(35)36-10-37-24)21(38-40)14-5-4-13(7-15(14)27)42-22-19(30)16(28)8-17(29)20(22)31/h4-5,7-8,10,12H,1-3,6,9H2,(H2,35,36,37)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260599
PNG
(US9532990, 73)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3cccc(F)c3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H20F2N6O2/c1-2-20(34)32-9-8-17(12-32)33-25-21(24(28)29-13-30-25)22(31-33)18-7-6-15(11-19(18)27)23(35)14-4-3-5-16(26)10-14/h2-7,10-11,13,17H,1,8-9,12H2,(H2,28,29,30)/t17-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260554
PNG
(US9532990, 28)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCC(CNC(=O)C=C)C1
Show InChI InChI=1S/C26H21F5N6O2/c1-2-19(38)33-10-12-3-4-13(7-12)37-26-20(25(32)34-11-35-26)23(36-37)15-6-5-14(8-16(15)27)39-24-21(30)17(28)9-18(29)22(24)31/h2,5-6,8-9,11-13H,1,3-4,7,10H2,(H,33,38)(H2,32,34,35)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260613
PNG
(US9532990, 87)
Show SMILES CC(C)(Cn1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12)NC(=O)C=C
Show InChI InChI=1S/C24H19F5N6O2/c1-4-16(36)33-24(2,3)9-35-23-17(22(30)31-10-32-23)20(34-35)12-6-5-11(7-13(12)25)37-21-18(28)14(26)8-15(27)19(21)29/h4-8,10H,1,9H2,2-3H3,(H,33,36)(H2,30,31,32)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260612
PNG
(US9532990, 86)
Show SMILES CN(CCCn1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12)C(=O)C=C
Show InChI InChI=1S/C24H19F5N6O2/c1-3-17(36)34(2)7-4-8-35-24-18(23(30)31-11-32-24)21(33-35)13-6-5-12(9-14(13)25)37-22-19(28)15(26)10-16(27)20(22)29/h3,5-6,9-11H,1,4,7-8H2,2H3,(H2,30,31,32)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260540
PNG
(US9532990, 14)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4cccc(F)c4)cc3F)c12)[C@H]1CC[C@@H](CC1)NC(=O)C=C
Show InChI InChI=1S/C26H24F2N6O2/c1-2-22(35)32-16-6-8-17(9-7-16)34-26-23(25(29)30-14-31-26)24(33-34)20-11-10-19(13-21(20)28)36-18-5-3-4-15(27)12-18/h2-5,10-14,16-17H,1,6-9H2,(H,32,35)(H2,29,30,31)/t16-,17-
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260529
PNG
(US9532990, 3)
Show SMILES Nc1ncnc2n(nc(-c3ccc(C(=O)c4cccc(F)c4)c(F)c3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H22F2N6O2/c1-2-21(35)33-10-4-7-18(13-33)34-26-22(25(29)30-14-31-26)23(32-34)15-8-9-19(20(28)12-15)24(36)16-5-3-6-17(27)11-16/h2-3,5-6,8-9,11-12,14,18H,1,4,7,10,13H2,(H2,29,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260614
PNG
(US9532990, 88)
Show SMILES CNC(=O)c1cc(Oc2ccc(-c3nn([C@@H]4CCN(C4)C(=O)C=C)c4ncnc(N)c34)c(F)c2)ccn1
Show InChI InChI=1S/C25H23FN8O3/c1-3-20(35)33-9-7-14(12-33)34-24-21(23(27)30-13-31-24)22(32-34)17-5-4-15(10-18(17)26)37-16-6-8-29-19(11-16)25(36)28-2/h3-6,8,10-11,13-14H,1,7,9,12H2,2H3,(H,28,36)(H2,27,30,31)/t14-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260641
PNG
(US9532990, 115)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)NO
Show InChI InChI=1S/C22H16F5N7O3/c23-12-5-10(37-19-16(26)13(24)6-14(25)17(19)27)1-2-11(12)18-15-20(28)29-8-30-21(15)34(31-18)9-3-4-33(7-9)22(35)32-36/h1-2,5-6,8-9,36H,3-4,7H2,(H,32,35)(H2,28,29,30)/t9-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260622
PNG
(US9532990, 96)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4nccc(Cl)n4)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C22H18ClFN8O2/c1-2-17(33)31-8-6-12(10-31)32-21-18(20(25)27-11-28-21)19(30-32)14-4-3-13(9-15(14)24)34-22-26-7-5-16(23)29-22/h2-5,7,9,11-12H,1,6,8,10H2,(H2,25,27,28)/t12-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260557
PNG
(US9532990, 31)
Show SMILES Nc1ncnc2n(CC3CCCN(C3)C(=O)C=C)nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12
Show InChI InChI=1S/C26H21F5N6O2/c1-2-19(38)36-7-3-4-13(10-36)11-37-26-20(25(32)33-12-34-26)23(35-37)15-6-5-14(8-16(15)27)39-24-21(30)17(28)9-18(29)22(24)31/h2,5-6,8-9,12-13H,1,3-4,7,10-11H2,(H2,32,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260616
PNG
(US9532990, 90)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccnc5ccccc45)cc3F)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C27H22FN7O2/c1-2-23(36)34-12-10-16(14-34)35-27-24(26(29)31-15-32-27)25(33-35)18-8-7-17(13-20(18)28)37-22-9-11-30-21-6-4-3-5-19(21)22/h2-9,11,13,15-16H,1,10,12,14H2,(H2,29,31,32)/t16-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260610
PNG
(US9532990, 84)
Show SMILES CC(CNC(=O)C=C)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C23H17F5N6O2/c1-3-16(35)30-8-10(2)34-23-17(22(29)31-9-32-23)20(33-34)12-5-4-11(6-13(12)24)36-21-18(27)14(25)7-15(26)19(21)28/h3-7,9-10H,1,8H2,2H3,(H,30,35)(H2,29,31,32)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260611
PNG
(US9532990, 85)
Show SMILES CN(CCn1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12)C(=O)C=C
Show InChI InChI=1S/C23H17F5N6O2/c1-3-16(35)33(2)6-7-34-23-17(22(29)30-10-31-23)20(32-34)12-5-4-11(8-13(12)24)36-21-18(27)14(25)9-15(26)19(21)28/h3-5,8-10H,1,6-7H2,2H3,(H2,29,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260567
PNG
(US9532990, 41)
Show SMILES NC(=O)\C=C\C(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C26H20F5N7O3/c27-15-8-13(41-24-21(30)16(28)9-17(29)22(24)31)3-4-14(15)23-20-25(33)34-11-35-26(20)38(36-23)12-2-1-7-37(10-12)19(40)6-5-18(32)39/h3-6,8-9,11-12H,1-2,7,10H2,(H2,32,39)(H2,33,34,35)/b6-5+
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260596
PNG
(US9532990, 70)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(CC(=C)C#N)C1
Show InChI InChI=1S/C26H20F5N7O/c1-13(9-32)10-37-6-2-3-14(11-37)38-26-20(25(33)34-12-35-26)23(36-38)16-5-4-15(7-17(16)27)39-24-21(30)18(28)8-19(29)22(24)31/h4-5,7-8,12,14H,1-3,6,10-11H2,(H2,33,34,35)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260551
PNG
(US9532990, 25)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CC[C@H](C1)NC(=O)C=C
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)34-11-3-4-12(7-11)36-25-19(24(31)32-10-33-25)22(35-36)14-6-5-13(8-15(14)26)38-23-20(29)16(27)9-17(28)21(23)30/h2,5-6,8-12H,1,3-4,7H2,(H,34,37)(H2,31,32,33)/t11-,12-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260572
PNG
(US9532990, 46 | US9717745, 4)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H17F5N6O2/c1-2-17(36)34-6-5-11(9-34)35-24-18(23(30)31-10-32-24)21(33-35)13-4-3-12(7-14(13)25)37-22-19(28)15(26)8-16(27)20(22)29/h2-4,7-8,10-11H,1,5-6,9H2,(H2,30,31,32)/t11-/m0/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260565
PNG
(US9532990, 39)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCC(CC1)NC(=O)CSSCC(=O)NC1CCC(CC1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C50H40F10N12O4S2/c51-29-13-25(75-45-39(57)31(53)15-32(54)40(45)58)9-11-27(29)43-37-47(61)63-19-65-49(37)71(69-43)23-5-1-21(2-6-23)67-35(73)17-77-78-18-36(74)68-22-3-7-24(8-4-22)72-50-38(48(62)64-20-66-50)44(70-72)28-12-10-26(14-30(28)52)76-46-41(59)33(55)16-34(56)42(46)60/h9-16,19-24H,1-8,17-18H2,(H,67,73)(H,68,74)(H2,61,63,65)(H2,62,64,66)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260560
PNG
(US9532990, 34 | US9717745, 2)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)35-7-3-4-12(10-35)36-25-19(24(31)32-11-33-25)22(34-36)14-6-5-13(8-15(14)26)38-23-20(29)16(27)9-17(28)21(23)30/h2,5-6,8-9,11-12H,1,3-4,7,10H2,(H2,31,32,33)/t12-/m0/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260556
PNG
(US9532990, 30)
Show SMILES Nc1ncnc2n(CC3CCN(CC3)C(=O)C=C)nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12
Show InChI InChI=1S/C26H21F5N6O2/c1-2-19(38)36-7-5-13(6-8-36)11-37-26-20(25(32)33-12-34-26)23(35-37)15-4-3-14(9-16(15)27)39-24-21(30)17(28)10-18(29)22(24)31/h2-4,9-10,12-13H,1,5-8,11H2,(H2,32,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260608
PNG
(US9532990, 82)
Show SMILES Nc1ncnc2n(CCNC(=O)C=C)nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12
Show InChI InChI=1S/C22H15F5N6O2/c1-2-15(34)29-5-6-33-22-16(21(28)30-9-31-22)19(32-33)11-4-3-10(7-12(11)23)35-20-17(26)13(24)8-14(25)18(20)27/h2-4,7-9H,1,5-6H2,(H,29,34)(H2,28,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260615
PNG
(US9532990, 89)
Show SMILES COc1cc2nccc(Oc3ccc(-c4nn([C@@H]5CCN(C5)C(=O)C=C)c5ncnc(N)c45)c(F)c3)c2cc1OC
Show InChI InChI=1S/C29H26FN7O4/c1-4-25(38)36-10-8-16(14-36)37-29-26(28(31)33-15-34-29)27(35-37)18-6-5-17(11-20(18)30)41-22-7-9-32-21-13-24(40-3)23(39-2)12-19(21)22/h4-7,9,11-13,15-16H,1,8,10,14H2,2-3H3,(H2,31,33,34)/t16-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260555
PNG
(US9532990, 29)
Show SMILES Nc1ncnc2n(CC3CCN(C3)C(=O)C=C)nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)35-6-5-12(9-35)10-36-25-19(24(31)32-11-33-25)22(34-36)14-4-3-13(7-15(14)26)38-23-20(29)16(27)8-17(28)21(23)30/h2-4,7-8,11-12H,1,5-6,9-10H2,(H2,31,32,33)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260602
PNG
(US9532990, 76)
Show SMILES CNC(=O)\C=C\CNC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C27H23F5N8O3/c1-34-19(41)3-2-7-35-27(42)39-8-6-13(11-39)40-26-20(25(33)36-12-37-26)23(38-40)15-5-4-14(9-16(15)28)43-24-21(31)17(29)10-18(30)22(24)32/h2-5,9-10,12-13H,6-8,11H2,1H3,(H,34,41)(H,35,42)(H2,33,36,37)/b3-2+/t13-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260552
PNG
(US9532990, 26)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CC[C@@H](C1)NC(=O)C=C
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)34-11-3-4-12(7-11)36-25-19(24(31)32-10-33-25)22(35-36)14-6-5-13(8-15(14)26)38-23-20(29)16(27)9-17(28)21(23)30/h2,5-6,8-12H,1,3-4,7H2,(H,34,37)(H2,31,32,33)/t11-,12+/m0/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260568
PNG
(US9532990, 42)
Show SMILES CNC(=O)\C=C\C(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C27H22F5N7O3/c1-34-19(40)6-7-20(41)38-8-2-3-13(11-38)39-27-21(26(33)35-12-36-27)24(37-39)15-5-4-14(9-16(15)28)42-25-22(31)17(29)10-18(30)23(25)32/h4-7,9-10,12-13H,2-3,8,11H2,1H3,(H,34,40)(H2,33,35,36)/b7-6+
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260637
PNG
(US9532990, 111)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)CF
Show InChI InChI=1S/C23H16F6N6O2/c24-7-16(36)34-4-3-10(8-34)35-23-17(22(30)31-9-32-23)20(33-35)12-2-1-11(5-13(12)25)37-21-18(28)14(26)6-15(27)19(21)29/h1-2,5-6,9-10H,3-4,7-8H2,(H2,30,31,32)/t10-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260640
PNG
(US9532990, 114)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(CCC#N)C1
Show InChI InChI=1S/C24H18F5N7O/c25-15-8-13(37-22-19(28)16(26)9-17(27)20(22)29)2-3-14(15)21-18-23(31)32-11-33-24(18)36(34-21)12-4-7-35(10-12)6-1-5-30/h2-3,8-9,11-12H,1,4,6-7,10H2,(H2,31,32,33)/t12-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260548
PNG
(US9532990, 22)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CC[C@@H](CC1)NC(=O)C=C
Show InChI InChI=1S/C26H21F5N6O2/c1-2-19(38)35-12-3-5-13(6-4-12)37-26-20(25(32)33-11-34-26)23(36-37)15-8-7-14(9-16(15)27)39-24-21(30)17(28)10-18(29)22(24)31/h2,7-13H,1,3-6H2,(H,35,38)(H2,32,33,34)/t12-,13+
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260595
PNG
(US9532990, 69)
Show SMILES CNC(=O)C(=C)CN1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C27H24F5N7O2/c1-13(27(40)34-2)10-38-7-3-4-14(11-38)39-26-20(25(33)35-12-36-26)23(37-39)16-6-5-15(8-17(16)28)41-24-21(31)18(29)9-19(30)22(24)32/h5-6,8-9,12,14H,1,3-4,7,10-11H2,2H3,(H,34,40)(H2,33,35,36)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260644
PNG
(US9532990, 118)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C23H15F5N6O/c24-15-5-12(35-21-19(27)16(25)6-17(26)20(21)28)1-2-13(15)14-8-34(11-3-4-33(7-11)9-29)23-18(14)22(30)31-10-32-23/h1-2,5-6,8,10-11H,3-4,7H2,(H2,30,31,32)/t11-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260578
PNG
(US9532990, 52)
Show SMILES CNC(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C24H20F5N7O2/c1-31-24(37)35-6-2-3-11(9-35)36-23-17(22(30)32-10-33-23)20(34-36)13-5-4-12(7-14(13)25)38-21-18(28)15(26)8-16(27)19(21)29/h4-5,7-8,10-11H,2-3,6,9H2,1H3,(H,31,37)(H2,30,32,33)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260527
PNG
(US9532990, 1)
Show SMILES Nc1ncnc2n(nc(-c3ccc(C(=O)c4ccc(F)cc4)c(F)c3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H22F2N6O2/c1-2-21(35)33-11-3-4-18(13-33)34-26-22(25(29)30-14-31-26)23(32-34)16-7-10-19(20(28)12-16)24(36)15-5-8-17(27)9-6-15/h2,5-10,12,14,18H,1,3-4,11,13H2,(H2,29,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260545
PNG
(US9532990, 19)
Show SMILES CS(=O)(=O)Nc1ccccc1Oc1ccc(-c2nn(C3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(F)c1
Show InChI InChI=1S/C26H26FN7O4S/c1-3-22(35)33-12-6-7-16(14-33)34-26-23(25(28)29-15-30-26)24(31-34)18-11-10-17(13-19(18)27)38-21-9-5-4-8-20(21)32-39(2,36)37/h3-5,8-11,13,15-16,32H,1,6-7,12,14H2,2H3,(H2,28,29,30)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260609
PNG
(US9532990, 83)
Show SMILES CC(NC(=O)C=C)C(C)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C24H19F5N6O2/c1-4-17(36)33-10(2)11(3)35-24-18(23(30)31-9-32-24)21(34-35)13-6-5-12(7-14(13)25)37-22-19(28)15(26)8-16(27)20(22)29/h4-11H,1H2,2-3H3,(H,33,36)(H2,30,31,32)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260561
PNG
(US9532990, 35)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCC(CC1)N1C(=O)C=CC1=O
Show InChI InChI=1S/C27H19F5N6O3/c28-16-9-14(41-25-22(31)17(29)10-18(30)23(25)32)5-6-15(16)24-21-26(33)34-11-35-27(21)38(36-24)13-3-1-12(2-4-13)37-19(39)7-8-20(37)40/h5-13H,1-4H2,(H2,33,34,35)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260535
PNG
(US9532990, 9)
Show SMILES Nc1ncnc2n(nc(-c3ccc(cc3F)C(=O)c3cccc(F)c3)c12)C1CCCN(C1)C(=O)C1CO1
Show InChI InChI=1S/C26H22F2N6O3/c27-16-4-1-3-14(9-16)23(35)15-6-7-18(19(28)10-15)22-21-24(29)30-13-31-25(21)34(32-22)17-5-2-8-33(11-17)26(36)20-12-37-20/h1,3-4,6-7,9-10,13,17,20H,2,5,8,11-12H2,(H2,29,30,31)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260645
PNG
(US9532990, 119)
Show SMILES Nc1ncnc2n(cc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C(Cl)CO
Show InChI InChI=1S/C25H19ClF5N5O3/c26-15(9-37)25(38)35-4-3-11(7-35)36-8-14(19-23(32)33-10-34-24(19)36)13-2-1-12(5-16(13)27)39-22-20(30)17(28)6-18(29)21(22)31/h1-2,5-6,8,10-11,15,37H,3-4,7,9H2,(H2,32,33,34)/t11-,15?/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260576
PNG
(US9532990, 50)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)C(=C)CO
Show InChI InChI=1S/C26H21F5N6O3/c1-12(10-38)26(39)36-6-2-3-13(9-36)37-25-19(24(32)33-11-34-25)22(35-37)15-5-4-14(7-16(15)27)40-23-20(30)17(28)8-18(29)21(23)31/h4-5,7-8,11,13,38H,1-3,6,9-10H2,(H2,32,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260563
PNG
(US9532990, 37)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CC[C@@H](C1)N1C(=O)C=CC1=O
Show InChI InChI=1S/C26H17F5N6O3/c27-15-8-13(40-24-21(30)16(28)9-17(29)22(24)31)3-4-14(15)23-20-25(32)33-10-34-26(20)37(35-23)12-2-1-11(7-12)36-18(38)5-6-19(36)39/h3-6,8-12H,1-2,7H2,(H2,32,33,34)/t11-,12-/m0/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260633
PNG
(US9532990, 107)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCCN(C1)C(=O)CF
Show InChI InChI=1S/C24H18F6N6O2/c25-8-17(37)35-5-1-2-11(9-35)36-24-18(23(31)32-10-33-24)21(34-36)13-4-3-12(6-14(13)26)38-22-19(29)15(27)7-16(28)20(22)30/h3-4,6-7,10-11H,1-2,5,8-9H2,(H2,31,32,33)/t11-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260638
PNG
(US9532990, 112)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C#N
Show InChI InChI=1S/C23H14F5N7O2/c24-13-5-11(37-21-18(27)14(25)6-15(26)19(21)28)1-2-12(13)20-17-22(30)31-9-32-23(17)35(33-20)10-3-4-34(8-10)16(36)7-29/h1-2,5-6,9-10H,3-4,8H2,(H2,30,31,32)/t10-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260630
PNG
(US9532990, 104)
Show SMILES C\C=C\C(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C25H19F5N6O2/c1-2-3-18(37)35-7-6-12(10-35)36-25-19(24(31)32-11-33-25)22(34-36)14-5-4-13(8-15(14)26)38-23-20(29)16(27)9-17(28)21(23)30/h2-5,8-9,11-12H,6-7,10H2,1H3,(H2,31,32,33)/b3-2+/t12-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260591
PNG
(US9532990, 65)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)CC(=O)C(F)(F)F
Show InChI InChI=1S/C26H18F8N6O3/c27-14-6-12(43-23-20(30)15(28)7-16(29)21(23)31)3-4-13(14)22-19-24(35)36-10-37-25(19)40(38-22)11-2-1-5-39(9-11)18(42)8-17(41)26(32,33)34/h3-4,6-7,10-11H,1-2,5,8-9H2,(H2,35,36,37)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260569
PNG
(US9532990, 43)
Show SMILES NC(=N)NC(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C24H20F5N9O2/c25-13-6-11(40-20-17(28)14(26)7-15(27)18(20)29)3-4-12(13)19-16-21(30)33-9-34-22(16)38(36-19)10-2-1-5-37(8-10)24(39)35-23(31)32/h3-4,6-7,9-10H,1-2,5,8H2,(H2,30,33,34)(H4,31,32,35,39)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260532
PNG
(US9532990, 6)
Show SMILES Cc1oncc1C(=O)N1CCCC(C1)n1nc(-c2ccc(cc2F)C(=O)c2cccc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H23F2N7O3/c1-15-21(12-34-40-15)28(39)36-9-3-6-19(13-36)37-27-23(26(31)32-14-33-27)24(35-37)20-8-7-17(11-22(20)30)25(38)16-4-2-5-18(29)10-16/h2,4-5,7-8,10-12,14,19H,3,6,9,13H2,1H3,(H2,31,32,33)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260584
PNG
(US9532990, 58)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)CCCl
Show InChI InChI=1S/C24H18ClF5N6O2/c25-5-3-17(37)35-6-4-11(9-35)36-24-18(23(31)32-10-33-24)21(34-36)13-2-1-12(7-14(13)26)38-22-19(29)15(27)8-16(28)20(22)30/h1-2,7-8,10-11H,3-6,9H2,(H2,31,32,33)/t11-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260585
PNG
(US9532990, 59)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)c1c[nH]cn1
Show InChI InChI=1S/C26H19F5N8O2/c27-15-6-13(41-23-20(30)16(28)7-17(29)21(23)31)3-4-14(15)22-19-24(32)35-11-36-25(19)39(37-22)12-2-1-5-38(9-12)26(40)18-8-33-10-34-18/h3-4,6-8,10-12H,1-2,5,9H2,(H,33,34)(H2,32,35,36)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260603
PNG
(US9532990, 77)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H14F8N6O3/c25-12-5-10(41-19-16(28)13(26)6-14(27)17(19)29)1-2-11(12)18-15-21(33)34-8-35-22(15)38(36-18)9-3-4-37(7-9)23(40)20(39)24(30,31)32/h1-2,5-6,8-9H,3-4,7H2,(H2,33,34,35)/t9-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260588
PNG
(US9532990, 62)
Show SMILES CN(C)CC(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C26H24F5N7O2/c1-36(2)11-19(39)37-7-3-4-13(10-37)38-26-20(25(32)33-12-34-26)23(35-38)15-6-5-14(8-16(15)27)40-24-21(30)17(28)9-18(29)22(24)31/h5-6,8-9,12-13H,3-4,7,10-11H2,1-2H3,(H2,32,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260639
PNG
(US9532990, 113)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(CC#N)C1
Show InChI InChI=1S/C23H16F5N7O/c24-14-7-12(36-21-18(27)15(25)8-16(26)19(21)28)1-2-13(14)20-17-22(30)31-10-32-23(17)35(33-20)11-3-5-34(9-11)6-4-29/h1-2,7-8,10-11H,3,5-6,9H2,(H2,30,31,32)/t11-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260553
PNG
(US9532990, 27)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H19F5N6O2/c1-2-18(37)35-7-5-12(6-8-35)36-25-19(24(31)32-11-33-25)22(34-36)14-4-3-13(9-15(14)26)38-23-20(29)16(27)10-17(28)21(23)30/h2-4,9-12H,1,5-8H2,(H2,31,32,33)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260594
PNG
(US9532990, 68)
Show SMILES CCOC(=O)C(=C)CN1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C28H25F5N6O3/c1-3-41-28(40)14(2)11-38-8-4-5-15(12-38)39-27-21(26(34)35-13-36-27)24(37-39)17-7-6-16(9-18(17)29)42-25-22(32)19(30)10-20(31)23(25)33/h6-7,9-10,13,15H,2-5,8,11-12H2,1H3,(H2,34,35,36)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260582
PNG
(US9532990, 56)
Show SMILES CNC(=O)CN1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C25H22F5N7O2/c1-32-18(38)10-36-6-2-3-12(9-36)37-25-19(24(31)33-11-34-25)22(35-37)14-5-4-13(7-15(14)26)39-23-20(29)16(27)8-17(28)21(23)30/h4-5,7-8,11-12H,2-3,6,9-10H2,1H3,(H,32,38)(H2,31,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260570
PNG
(US9532990, 44)
Show SMILES CC(=O)CC(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C26H21F5N6O3/c1-12(38)7-19(39)36-6-2-3-13(10-36)37-26-20(25(32)33-11-34-26)23(35-37)15-5-4-14(8-16(15)27)40-24-21(30)17(28)9-18(29)22(24)31/h4-5,8-9,11,13H,2-3,6-7,10H2,1H3,(H2,32,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260564
PNG
(US9532990, 38)
Show SMILES Nc1ncnc2n(CCCN3C(=O)C=CC3=O)nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12
Show InChI InChI=1S/C24H15F5N6O3/c25-13-8-11(38-22-19(28)14(26)9-15(27)20(22)29)2-3-12(13)21-18-23(30)31-10-32-24(18)35(33-21)7-1-6-34-16(36)4-5-17(34)37/h2-5,8-10H,1,6-7H2,(H2,30,31,32)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260634
PNG
(US9532990, 108)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CCCN(C1)C(=O)CF
Show InChI InChI=1S/C24H18F6N6O2/c25-8-17(37)35-5-1-2-11(9-35)36-24-18(23(31)32-10-33-24)21(34-36)13-4-3-12(6-14(13)26)38-22-19(29)15(27)7-16(28)20(22)30/h3-4,6-7,10-11H,1-2,5,8-9H2,(H2,31,32,33)/t11-/m0/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260589
PNG
(US9532990, 63)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)C1CNC(=O)S1
Show InChI InChI=1S/C26H20F5N7O3S/c27-14-6-12(41-22-19(30)15(28)7-16(29)20(22)31)3-4-13(14)21-18-23(32)34-10-35-24(18)38(36-21)11-2-1-5-37(9-11)25(39)17-8-33-26(40)42-17/h3-4,6-7,10-11,17H,1-2,5,8-9H2,(H,33,40)(H2,32,34,35)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260575
PNG
(US9532990, 49)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)C(=C)C#N
Show InChI InChI=1S/C26H18F5N7O2/c1-12(9-32)26(39)37-6-2-3-13(10-37)38-25-19(24(33)34-11-35-25)22(36-38)15-5-4-14(7-16(15)27)40-23-20(30)17(28)8-18(29)21(23)31/h4-5,7-8,11,13H,1-3,6,10H2,(H2,33,34,35)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260627
PNG
(US9532990, 101)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCCN(C1)C(=O)C(Cl)Cl
Show InChI InChI=1S/C24H17Cl2F5N6O2/c25-21(26)24(38)36-5-1-2-10(8-36)37-23-16(22(32)33-9-34-23)19(35-37)12-4-3-11(6-13(12)27)39-20-17(30)14(28)7-15(29)18(20)31/h3-4,6-7,9-10,21H,1-2,5,8H2,(H2,32,33,34)/t10-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260577
PNG
(US9532990, 51)
Show SMILES Nc1ncnc2n(CCN3C(=O)C=CC3=O)nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12
Show InChI InChI=1S/C23H13F5N6O3/c24-12-7-10(37-21-18(27)13(25)8-14(26)19(21)28)1-2-11(12)20-17-22(29)30-9-31-23(17)34(32-20)6-5-33-15(35)3-4-16(33)36/h1-4,7-9H,5-6H2,(H2,29,30,31)
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n/an/a 527n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260629
PNG
(US9532990, 103)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C(Cl)Cl
Show InChI InChI=1S/C23H15Cl2F5N6O2/c24-20(25)23(37)35-4-3-9(7-35)36-22-15(21(31)32-8-33-22)18(34-36)11-2-1-10(5-12(11)26)38-19-16(29)13(27)6-14(28)17(19)30/h1-2,5-6,8-9,20H,3-4,7H2,(H2,31,32,33)/t9-/m1/s1
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n/an/a 546n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260586
PNG
(US9532990, 60)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)c1cccnc1
Show InChI InChI=1S/C28H20F5N7O2/c29-18-9-16(42-25-22(32)19(30)10-20(31)23(25)33)5-6-17(18)24-21-26(34)36-13-37-27(21)40(38-24)15-4-2-8-39(12-15)28(41)14-3-1-7-35-11-14/h1,3,5-7,9-11,13,15H,2,4,8,12H2,(H2,34,36,37)
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n/an/a 576n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260593
PNG
(US9532990, 67)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)CC(=O)C1CC1
Show InChI InChI=1S/C28H23F5N6O3/c29-17-8-15(42-26-23(32)18(30)9-19(31)24(26)33)5-6-16(17)25-22-27(34)35-12-36-28(22)39(37-25)14-2-1-7-38(11-14)21(41)10-20(40)13-3-4-13/h5-6,8-9,12-14H,1-4,7,10-11H2,(H2,34,35,36)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260631
PNG
(US9532990, 105)
Show SMILES CC(=C)C(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C25H19F5N6O2/c1-11(2)25(37)35-6-5-12(9-35)36-24-18(23(31)32-10-33-24)21(34-36)14-4-3-13(7-15(14)26)38-22-19(29)16(27)8-17(28)20(22)30/h3-4,7-8,10,12H,1,5-6,9H2,2H3,(H2,31,32,33)/t12-/m1/s1
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n/an/a 589n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260562
PNG
(US9532990, 36)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCC(C1)N1C(=O)C=CC1=O
Show InChI InChI=1S/C27H19F5N6O3/c28-16-9-14(41-25-22(31)17(29)10-18(30)23(25)32)4-5-15(16)24-21-26(33)34-11-35-27(21)38(36-24)13-3-1-2-12(8-13)37-19(39)6-7-20(37)40/h4-7,9-13H,1-3,8H2,(H2,33,34,35)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260583
PNG
(US9532990, 57)
Show SMILES CNC(=O)C(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C25H20F5N7O3/c1-32-24(38)25(39)36-6-2-3-11(9-36)37-23-17(22(31)33-10-34-23)20(35-37)13-5-4-12(7-14(13)26)40-21-18(29)15(27)8-16(28)19(21)30/h4-5,7-8,10-11H,2-3,6,9H2,1H3,(H,32,38)(H2,31,33,34)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260643
PNG
(US9532990, 117)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C(O)=O
Show InChI InChI=1S/C23H15F5N6O4/c24-12-5-10(38-19-16(27)13(25)6-14(26)17(19)28)1-2-11(12)18-15-20(29)30-8-31-21(15)34(32-18)9-3-4-33(7-9)22(35)23(36)37/h1-2,5-6,8-9H,3-4,7H2,(H,36,37)(H2,29,30,31)/t9-/m1/s1
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260592
PNG
(US9532990, 66)
Show SMILES Fc1cc(F)c(F)c(Oc2ccc(-c3nn(C4CCCNC4)c4ncnc(NC(=O)CC(=O)C(F)(F)F)c34)c(F)c2)c1F
Show InChI InChI=1S/C26H18F8N6O3/c27-14-6-12(43-23-20(30)15(28)7-16(29)21(23)31)3-4-13(14)22-19-24(38-18(42)8-17(41)26(32,33)34)36-10-37-25(19)40(39-22)11-2-1-5-35-9-11/h3-4,6-7,10-11,35H,1-2,5,8-9H2,(H,36,37,38,42)
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260533
PNG
(US9532990, 7)
Show SMILES C\C(O)=C(\C#N)C(=O)N1CCCC(C1)n1nc(-c2ccc(cc2F)C(=O)c2cccc(F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C28H23F2N7O3/c1-15(38)21(12-31)28(40)36-9-3-6-19(13-36)37-27-23(26(32)33-14-34-27)24(35-37)20-8-7-17(11-22(20)30)25(39)16-4-2-5-18(29)10-16/h2,4-5,7-8,10-11,14,19,38H,3,6,9,13H2,1H3,(H2,32,33,34)/b21-15+
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Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260574
PNG
(US9532990, 48)
Show SMILES COC(=O)C(=C/C)\C(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C28H23F5N6O4/c1-3-15(28(41)42-2)27(40)38-8-4-5-13(11-38)39-26-20(25(34)35-12-36-26)23(37-39)16-7-6-14(9-17(16)29)43-24-21(32)18(30)10-19(31)22(24)33/h3,6-7,9-10,12-13H,4-5,8,11H2,1-2H3,(H2,34,35,36)/b15-3-
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n/an/a 964n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260550
PNG
(US9532990, 24)
Show SMILES Fc1cc(F)c(F)c(Oc2ccc3c4nn(C5CCN(C5)C(=O)C=C)c5ncnc([nH]c3c2)c45)c1F
Show InChI InChI=1S/C24H16F4N6O2/c1-2-17(35)33-6-5-11(9-33)34-24-18-21(32-34)13-4-3-12(7-16(13)31-23(18)29-10-30-24)36-22-19(27)14(25)8-15(26)20(22)28/h2-4,7-8,10-11H,1,5-6,9H2,(H,29,30,31)
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n/an/a 1.02E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260606
PNG
(US9532990, 80)
Show SMILES CC(C)(CO)C(=O)C(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C27H23F5N6O4/c1-27(2,10-39)23(40)26(41)37-6-5-12(9-37)38-25-18(24(33)34-11-35-25)21(36-38)14-4-3-13(7-15(14)28)42-22-19(31)16(29)8-17(30)20(22)32/h3-4,7-8,11-12,39H,5-6,9-10H2,1-2H3,(H2,33,34,35)/t12-/m1/s1
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n/an/a 1.28E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260635
PNG
(US9532990, 109)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)c1ncco1
Show InChI InChI=1S/C25H16F5N7O3/c26-14-7-12(40-21-18(29)15(27)8-16(28)19(21)30)1-2-13(14)20-17-22(31)33-10-34-23(17)37(35-20)11-3-5-36(9-11)25(38)24-32-4-6-39-24/h1-2,4,6-8,10-11H,3,5,9H2,(H2,31,33,34)/t11-/m1/s1
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n/an/a 1.28E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260628
PNG
(US9532990, 102)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@H]1CCCN(C1)C(=O)C(Cl)Cl
Show InChI InChI=1S/C24H17Cl2F5N6O2/c25-21(26)24(38)36-5-1-2-10(8-36)37-23-16(22(32)33-9-34-23)19(35-37)12-4-3-11(6-13(12)27)39-20-17(30)14(28)7-15(29)18(20)31/h3-4,6-7,9-10,21H,1-2,5,8H2,(H2,32,33,34)/t10-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260580
PNG
(US9532990, 54)
Show SMILES CN\C(=N/C#N)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C25H20F5N9O/c1-33-25(34-10-31)38-6-2-3-12(9-38)39-24-18(23(32)35-11-36-24)21(37-39)14-5-4-13(7-15(14)26)40-22-19(29)16(27)8-17(28)20(22)30/h4-5,7-8,11-12H,2-3,6,9H2,1H3,(H,33,34)(H2,32,35,36)
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n/an/a 1.62E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260566
PNG
(US9532990, 40)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCC(CC1)N1C(=O)CSC1=O
Show InChI InChI=1S/C26H19F5N6O3S/c27-15-7-13(40-23-20(30)16(28)8-17(29)21(23)31)5-6-14(15)22-19-24(32)33-10-34-25(19)37(35-22)12-3-1-11(2-4-12)36-18(38)9-41-26(36)39/h5-8,10-12H,1-4,9H2,(H2,32,33,34)
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n/an/a 1.64E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260579
PNG
(US9532990, 53)
Show SMILES CNC(=N)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C24H21F5N8O/c1-32-24(31)36-6-2-3-11(9-36)37-23-17(22(30)33-10-34-23)20(35-37)13-5-4-12(7-14(13)25)38-21-18(28)15(26)8-16(27)19(21)29/h4-5,7-8,10-11H,2-3,6,9H2,1H3,(H2,31,32)(H2,30,33,34)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260605
PNG
(US9532990, 79)
Show SMILES CC(C)C(=O)C(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C26H21F5N6O3/c1-11(2)22(38)26(39)36-6-5-12(9-36)37-25-18(24(32)33-10-34-25)21(35-37)14-4-3-13(7-15(14)27)40-23-19(30)16(28)8-17(29)20(23)31/h3-4,7-8,10-12H,5-6,9H2,1-2H3,(H2,32,33,34)/t12-/m1/s1
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n/an/a 1.66E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260581
PNG
(US9532990, 55)
Show SMILES CN\C(=N/[N+]([O-])=O)N1CCCC(C1)n1nc(-c2ccc(Oc3c(F)c(F)cc(F)c3F)cc2F)c2c(N)ncnc12
Show InChI InChI=1S/C24H20F5N9O3/c1-31-24(35-38(39)40)36-6-2-3-11(9-36)37-23-17(22(30)32-10-33-23)20(34-37)13-5-4-12(7-14(13)25)41-21-18(28)15(26)8-16(27)19(21)29/h4-5,7-8,10-11H,2-3,6,9H2,1H3,(H,31,35)(H2,30,32,33)
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n/an/a 1.74E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260604
PNG
(US9532990, 78)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)C(=O)C1CC1
Show InChI InChI=1S/C26H19F5N6O3/c27-15-7-13(40-23-19(30)16(28)8-17(29)20(23)31)3-4-14(15)21-18-24(32)33-10-34-25(18)37(35-21)12-5-6-36(9-12)26(39)22(38)11-1-2-11/h3-4,7-8,10-12H,1-2,5-6,9H2,(H2,32,33,34)/t12-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260536
PNG
(US9532990, 10)
Show SMILES CC(C)(C)OC(=O)N1CCCC(C1)n1nc(-c2ccc(cc2F)C(=O)c2ccccc2[N+]([O-])=O)c2c(N)ncnc12
Show InChI InChI=1S/C28H28FN7O5/c1-28(2,3)41-27(38)34-12-6-7-17(14-34)35-26-22(25(30)31-15-32-26)23(33-35)18-11-10-16(13-20(18)29)24(37)19-8-4-5-9-21(19)36(39)40/h4-5,8-11,13,15,17H,6-7,12,14H2,1-3H3,(H2,30,31,32)
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n/an/a 1.97E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260607
PNG
(US9532990, 81)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)C1CCCN(C1)C(=O)C(=O)C1CC1
Show InChI InChI=1S/C27H21F5N6O3/c28-16-8-14(41-24-20(31)17(29)9-18(30)21(24)32)5-6-15(16)22-19-25(33)34-11-35-26(19)38(36-22)13-2-1-7-37(10-13)27(40)23(39)12-3-4-12/h5-6,8-9,11-13H,1-4,7,10H2,(H2,33,34,35)
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n/an/a 2.24E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260618
PNG
(US9532990, 92)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C30H21F5N6O2/c31-20-12-18(43-28-25(34)21(32)13-22(33)26(28)35)7-8-19(20)27-24-29(36)37-15-38-30(24)41(39-27)17-10-11-40(14-17)23(42)9-6-16-4-2-1-3-5-16/h1-9,12-13,15,17H,10-11,14H2,(H2,36,37,38)/b9-6+/t17-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260619
PNG
(US9532990, 93)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)\C=C\c1ccccc1F
Show InChI InChI=1S/C30H20F6N6O2/c31-19-4-2-1-3-15(19)5-8-23(43)41-10-9-16(13-41)42-30-24(29(37)38-14-39-30)27(40-42)18-7-6-17(11-20(18)32)44-28-25(35)21(33)12-22(34)26(28)36/h1-8,11-12,14,16H,9-10,13H2,(H2,37,38,39)/b8-5+/t16-/m1/s1
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n/an/a 2.65E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260636
PNG
(US9532990, 110)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12)[C@@H]1CCN(C1)C(=O)c1nc2ccccc2o1
Show InChI InChI=1S/C29H18F5N7O3/c30-16-9-14(43-25-22(33)17(31)10-18(32)23(25)34)5-6-15(16)24-21-26(35)36-12-37-27(21)41(39-24)13-7-8-40(11-13)29(42)28-38-19-3-1-2-4-20(19)44-28/h1-6,9-10,12-13H,7-8,11H2,(H2,35,36,37)/t13-/m1/s1
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n/an/a 5.27E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM260558
PNG
(US9532990, 32)
Show SMILES Nc1ncnc2n(CC3CCC(C3)NC(=O)C=C)nc(-c3ccc(Oc4c(F)c(F)cc(F)c4F)cc3F)c12
Show InChI InChI=1S/C26H21F5N6O2/c1-2-19(38)35-13-4-3-12(7-13)10-37-26-20(25(32)33-11-34-26)23(36-37)15-6-5-14(8-16(15)27)39-24-21(30)17(28)9-18(29)22(24)31/h2,5-6,8-9,11-13H,1,3-4,7,10H2,(H,35,38)(H2,32,33,34)
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n/an/a 7.22E+3n/an/an/an/an/an/a



Zhejiang DTRM Biopharma Co. Ltd.

US Patent


Assay Description
The enzyme reaction mixture of BTK wild type standard HTRF assay contained 1 nM BTK wild type, 1 μM biotin-TK1 peptide, and 30 μM ATP in a ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%