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Patent code US9533985

Compile Data Set for Download or QSAR
Found 193 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260669
PNG
(US9533985, 57)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-14-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)10-24(30(45)46)38-28(43)27-22(32)11-18(12-23(27)33)39-50(48,49)26-7-6-20(13-36-26)41-16-35-15-37-41/h2-9,11-16,24,39H,10H2,1H3,(H,38,43)(H,45,46)/t24-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0600n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260666
PNG
(US9533985, 54)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H24F2N8O7S/c1-42-27-16-36-9-8-23(27)31(45)43(33(42)48)22-5-2-18(3-6-22)10-26(32(46)47)40-30(44)29-24(34)11-21(12-25(29)35)41-51(49,50)28-7-4-19(15-39-28)20-13-37-17-38-14-20/h2-9,11-17,26,41H,10H2,1H3,(H,40,44)(H,46,47)/t26-/m0/s1
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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0770n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260683
PNG
(US9533985, 71)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-16-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)12-24(30(45)46)37-28(43)27-22(32)13-18(14-23(27)33)38-50(48,49)26-7-6-20(15-35-26)41-11-10-36-39-41/h2-11,13-16,24,38H,12H2,1H3,(H,37,43)(H,45,46)/t24-/m0/s1
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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0980n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260680
PNG
(US9533985, 68)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccnc(F)c4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H25F3N6O7S/c1-43-29-18-39-12-11-25(29)33(46)44(35(43)49)23-6-2-19(3-7-23)14-28(34(47)48)41-32(45)31-26(36)16-22(17-27(31)37)42-52(50,51)24-8-4-20(5-9-24)21-10-13-40-30(38)15-21/h2-13,15-18,28,42H,14H2,1H3,(H,41,45)(H,47,48)/t28-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.130n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260671
PNG
(US9533985, 59)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4nccs4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H23F2N7O7S2/c1-40-25-16-35-9-8-21(25)30(43)41(32(40)46)20-5-2-17(3-6-20)12-24(31(44)45)38-28(42)27-22(33)13-19(14-23(27)34)39-50(47,48)26-7-4-18(15-37-26)29-36-10-11-49-29/h2-11,13-16,24,39H,12H2,1H3,(H,38,42)(H,44,45)/t24-/m0/s1
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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.170n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260681
PNG
(US9533985, 69)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C4=CCNCC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H30F2N6O7S/c1-42-30-19-39-15-12-26(30)33(45)43(35(42)48)24-6-2-20(3-7-24)16-29(34(46)47)40-32(44)31-27(36)17-23(18-28(31)37)41-51(49,50)25-8-4-21(5-9-25)22-10-13-38-14-11-22/h2-10,12,15,17-19,29,38,41H,11,13-14,16H2,1H3,(H,40,44)(H,46,47)/t29-/m0/s1
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UniProtKB/TrEMBL

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.210n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260660
PNG
(US9533985, 48)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncc[nH]4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25F2N7O7S/c1-41-27-17-36-11-10-23(27)31(44)42(33(41)47)21-6-2-18(3-7-21)14-26(32(45)46)39-30(43)28-24(34)15-20(16-25(28)35)40-50(48,49)22-8-4-19(5-9-22)29-37-12-13-38-29/h2-13,15-17,26,40H,14H2,1H3,(H,37,38)(H,39,43)(H,45,46)/t26-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260653
PNG
(US9533985, 41)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N7O7S/c1-42-28-18-37-14-11-24(28)32(45)43(34(42)48)22-7-3-19(4-8-22)15-27(33(46)47)40-31(44)29-25(35)16-21(17-26(29)36)41-51(49,50)23-9-5-20(6-10-23)30-38-12-2-13-39-30/h2-14,16-18,27,41H,15H2,1H3,(H,40,44)(H,46,47)/t27-/m0/s1
PDB
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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.260n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260689
PNG
(US9533985, 77)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-c5ncccn5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C33H26F2N8O7S/c1-41-17-38-29-27(41)31(45)43(33(48)42(29)2)21-8-4-18(5-9-21)14-25(32(46)47)39-30(44)26-23(34)15-20(16-24(26)35)40-51(49,50)22-10-6-19(7-11-22)28-36-12-3-13-37-28/h3-13,15-17,25,40H,14H2,1-2H3,(H,39,44)(H,46,47)/t25-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
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B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.270n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260667
PNG
(US9533985, 55)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-14-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)10-24(30(45)46)38-28(43)27-22(32)11-18(12-23(27)33)39-50(48,49)20-6-7-26(36-13-20)41-16-35-15-37-41/h2-9,11-16,24,39H,10H2,1H3,(H,38,43)(H,45,46)/t24-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.270n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260654
PNG
(US9533985, 42)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)-c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N7O7S/c1-42-29-18-38-13-10-24(29)32(45)43(34(42)48)22-4-2-19(3-5-22)14-28(33(46)47)40-31(44)30-25(35)15-21(16-26(30)36)41-51(49,50)23-6-7-27(39-17-23)20-8-11-37-12-9-20/h2-13,15-18,28,41H,14H2,1H3,(H,40,44)(H,46,47)/t28-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.270n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260662
PNG
(US9533985, 50)
Show SMILES Cc1ccc(cn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-3-6-23(18-40-20)22-7-11-26(12-8-22)52(50,51)42-24-16-28(37)32(29(38)17-24)33(45)41-30(35(47)48)15-21-4-9-25(10-5-21)44-34(46)27-13-14-39-19-31(27)43(2)36(44)49/h3-14,16-19,30,42H,15H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260659
PNG
(US9533985, 47)
Show SMILES CN(C)c1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5cncn5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C35H30F2N8O7S/c1-42(2)24-10-13-30-26(17-24)33(47)45(35(50)43(30)3)23-6-4-20(5-7-23)14-29(34(48)49)40-32(46)31-27(36)15-21(16-28(31)37)41-53(51,52)25-11-8-22(9-12-25)44-19-38-18-39-44/h4-13,15-19,29,41H,14H2,1-3H3,(H,40,46)(H,48,49)/t29-/m0/s1
PDB
MMDB

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UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260687
PNG
(US9533985, 75)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-c5ccncc5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C34H27F2N7O7S/c1-41-18-38-30-29(41)32(45)43(34(48)42(30)2)23-7-3-19(4-8-23)15-27(33(46)47)39-31(44)28-25(35)16-22(17-26(28)36)40-51(49,50)24-9-5-20(6-10-24)21-11-13-37-14-12-21/h3-14,16-18,27,40H,15H2,1-2H3,(H,39,44)(H,46,47)/t27-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.380n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260686
PNG
(US9533985, 74)
Show SMILES Cc1cc(ccn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3ncn(C)c3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C35H29F2N7O7S/c1-19-14-22(12-13-38-19)21-6-10-25(11-7-21)52(50,51)41-23-16-26(36)29(27(37)17-23)32(45)40-28(34(47)48)15-20-4-8-24(9-5-20)44-33(46)30-31(39-18-42(30)2)43(3)35(44)49/h4-14,16-18,28,41H,15H2,1-3H3,(H,40,45)(H,47,48)/t28-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.390n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260682
PNG
(US9533985, 70)
Show SMILES Cc1cc(cc(C)n1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C37H30F2N6O7S/c1-20-14-24(15-21(2)41-20)23-6-10-27(11-7-23)53(51,52)43-25-17-29(38)33(30(39)18-25)34(46)42-31(36(48)49)16-22-4-8-26(9-5-22)45-35(47)28-12-13-40-19-32(28)44(3)37(45)50/h4-15,17-19,31,43H,16H2,1-3H3,(H,42,46)(H,48,49)/t31-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.410n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260661
PNG
(US9533985, 49)
Show SMILES Cc1cc(ccn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-15-23(11-14-40-20)22-5-9-26(10-6-22)52(50,51)42-24-17-28(37)32(29(38)18-24)33(45)41-30(35(47)48)16-21-3-7-25(8-4-21)44-34(46)27-12-13-39-19-31(27)43(2)36(44)49/h3-15,17-19,30,42H,16H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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n/an/a 0.430n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260673
PNG
(US9533985, 61)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4nccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H24F2N8O7S/c1-40-27-17-35-11-10-23(27)30(44)41(32(40)47)20-4-2-18(3-5-20)14-26(31(45)46)38-29(43)28-24(33)15-19(16-25(28)34)39-50(48,49)22-8-6-21(7-9-22)42-36-12-13-37-42/h2-13,15-17,26,39H,14H2,1H3,(H,38,43)(H,45,46)/t26-/m0/s1
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n/an/a 0.460n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260679
PNG
(US9533985, 67)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H26F2N6O7S/c1-42-30-19-39-15-12-26(30)33(45)43(35(42)48)24-6-2-20(3-7-24)16-29(34(46)47)40-32(44)31-27(36)17-23(18-28(31)37)41-51(49,50)25-8-4-21(5-9-25)22-10-13-38-14-11-22/h2-15,17-19,29,41H,16H2,1H3,(H,40,44)(H,46,47)/t29-/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260677
PNG
(US9533985, 65)
Show SMILES Cc1cnccc1-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-18-39-13-11-26(20)22-5-9-25(10-6-22)52(50,51)42-23-16-28(37)32(29(38)17-23)33(45)41-30(35(47)48)15-21-3-7-24(8-4-21)44-34(46)27-12-14-40-19-31(27)43(2)36(44)49/h3-14,16-19,30,42H,15H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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US Patent
n/an/a 0.560n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260656
PNG
(US9533985, 44)
Show SMILES CCNC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)ccn(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C30H27F2N5O8S/c1-3-33-27(39)18-6-10-21(11-7-18)46(44,45)35-19-15-22(31)26(23(32)16-19)28(40)34-24(29(41)42)14-17-4-8-20(9-5-17)37-25(38)12-13-36(2)30(37)43/h4-13,15-16,24,35H,3,14H2,1-2H3,(H,33,39)(H,34,40)(H,41,42)/t24-/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260674
PNG
(US9533985, 62)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25F2N7O7S/c1-40-28-18-36-13-11-24(28)31(44)42(33(40)47)22-5-3-19(4-6-22)15-27(32(45)46)38-30(43)29-25(34)16-20(17-26(29)35)39-50(48,49)23-9-7-21(8-10-23)41-14-2-12-37-41/h2-14,16-18,27,39H,15H2,1H3,(H,38,43)(H,45,46)/t27-/m0/s1
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n/an/a 0.640n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260683
PNG
(US9533985, 71)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-16-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)12-24(30(45)46)37-28(43)27-22(32)13-18(14-23(27)33)38-50(48,49)26-7-6-20(15-35-26)41-11-10-36-39-41/h2-11,13-16,24,38H,12H2,1H3,(H,37,43)(H,45,46)/t24-/m0/s1
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n/an/a 0.720n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65394
PNG
(US9533985, 159 | US9533985, 40)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-12-9-25(40)39(30(38)44)20-6-3-17(4-7-20)13-23(29(42)43)36-28(41)26-21(31)14-19(15-22(26)32)37-47(45,46)24-8-5-18(16-35-24)27-33-10-2-11-34-27/h2-12,14-16,23,37H,13H2,1H3,(H,36,41)(H,42,43)/t23-/m0/s1
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n/an/a 0.730n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260690
PNG
(US9533985, 78)
Show SMILES COc1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)C(=O)NC5CC5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C36H31F2N5O9S/c1-42-30-14-11-24(52-2)18-26(30)34(46)43(36(42)49)23-9-3-19(4-10-23)15-29(35(47)48)40-33(45)31-27(37)16-22(17-28(31)38)41-53(50,51)25-12-5-20(6-13-25)32(44)39-21-7-8-21/h3-6,9-14,16-18,21,29,41H,7-8,15H2,1-2H3,(H,39,44)(H,40,45)(H,47,48)/t29-/m0/s1
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n/an/a 0.790n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260675
PNG
(US9533985, 63)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-9-8-26(40)39(30(38)44)21-5-2-17(3-6-21)10-24(29(42)43)36-28(41)27-22(31)11-20(12-23(27)32)37-47(45,46)25-7-4-18(15-35-25)19-13-33-16-34-14-19/h2-9,11-16,24,37H,10H2,1H3,(H,36,41)(H,42,43)/t24-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260651
PNG
(US9533985, 39)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23FN6O7S/c1-35-25-16-32-13-10-22(25)27(38)36(29(35)41)19-5-2-17(3-6-19)14-24(28(39)40)33-26(37)21-7-4-18(15-23(21)30)34-44(42,43)20-8-11-31-12-9-20/h2-13,15-16,24,34H,14H2,1H3,(H,33,37)(H,39,40)/t24-/m0/s1
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n/an/a 0.830n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260655
PNG
(US9533985, 43)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H26F2N6O7S/c1-40-29-19-37-13-12-25(29)32(44)42(34(40)47)23-6-4-20(5-7-23)16-28(33(45)46)38-31(43)30-26(35)17-21(18-27(30)36)39-50(48,49)24-10-8-22(9-11-24)41-14-2-3-15-41/h2-15,17-19,28,39H,16H2,1H3,(H,38,43)(H,45,46)/t28-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260685
PNG
(US9533985, 73)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-10-8-24(39)38(28(36)43)18-4-2-16(3-5-18)12-22(27(41)42)33-26(40)25-20(29)13-17(14-21(25)30)34-46(44,45)23-7-6-19(15-31-23)37-11-9-32-35-37/h2-11,13-15,22,34H,12H2,1H3,(H,33,40)(H,41,42)/t22-/m0/s1
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n/an/a 0.950n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65383
PNG
(BDBM260657 | US9533985, 157)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC4CC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H27F2N5O8S/c1-37-13-12-26(39)38(31(37)44)21-8-2-17(3-9-21)14-25(30(42)43)35-29(41)27-23(32)15-20(16-24(27)33)36-47(45,46)22-10-4-18(5-11-22)28(40)34-19-6-7-19/h2-5,8-13,15-16,19,25,36H,6-7,14H2,1H3,(H,34,40)(H,35,41)(H,42,43)/t25-/m0/s1
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n/an/a 0.970n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260670
PNG
(US9533985, 58)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23F2N7O7S/c1-36-12-10-25(39)38(29(36)43)20-4-2-17(3-5-20)14-24(28(41)42)33-27(40)26-22(30)15-18(16-23(26)31)34-46(44,45)21-8-6-19(7-9-21)37-13-11-32-35-37/h2-13,15-16,24,34H,14H2,1H3,(H,33,40)(H,41,42)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260672
PNG
(US9533985, 60)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H24F2N6O7S/c1-38-11-10-27(40)39(31(38)44)22-6-2-18(3-7-22)12-26(30(42)43)36-29(41)28-24(32)13-21(14-25(28)33)37-47(45,46)23-8-4-19(5-9-23)20-15-34-17-35-16-20/h2-11,13-17,26,37H,12H2,1H3,(H,36,41)(H,42,43)/t26-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260658
PNG
(US9533985, 46)
Show SMILES COc1cc2c(cn1)n(C)c(=O)n(-c1ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncccn4)cc3F)C(O)=O)cc1)c2=O
Show InChI InChI=1S/C35H27F2N7O8S/c1-43-28-18-40-29(52-2)17-24(28)33(46)44(35(43)49)22-8-4-19(5-9-22)14-27(34(47)48)41-32(45)30-25(36)15-21(16-26(30)37)42-53(50,51)23-10-6-20(7-11-23)31-38-12-3-13-39-31/h3-13,15-18,27,42H,14H2,1-2H3,(H,41,45)(H,47,48)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260681
PNG
(US9533985, 69)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C4=CCNCC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H30F2N6O7S/c1-42-30-19-39-15-12-26(30)33(45)43(35(42)48)24-6-2-20(3-7-24)16-29(34(46)47)40-32(44)31-27(36)17-23(18-28(31)37)41-51(49,50)25-8-4-21(5-9-25)22-10-13-38-14-11-22/h2-10,12,15,17-19,29,38,41H,11,13-14,16H2,1H3,(H,40,44)(H,46,47)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260669
PNG
(US9533985, 57)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-14-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)10-24(30(45)46)38-28(43)27-22(32)11-18(12-23(27)33)39-50(48,49)26-7-6-20(13-36-26)41-16-35-15-37-41/h2-9,11-16,24,39H,10H2,1H3,(H,38,43)(H,45,46)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260678
PNG
(US9533985, 66)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccoc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O8S/c1-40-29-17-37-12-10-25(29)32(43)41(34(40)46)23-6-2-19(3-7-23)14-28(33(44)45)38-31(42)30-26(35)15-22(16-27(30)36)39-50(47,48)24-8-4-20(5-9-24)21-11-13-49-18-21/h2-13,15-18,28,39H,14H2,1H3,(H,38,42)(H,44,45)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260684
PNG
(US9533985, 72)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4nccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-11-8-24(39)37(28(36)43)18-4-2-16(3-5-18)12-22(27(41)42)34-26(40)25-20(29)13-17(14-21(25)30)35-46(44,45)23-7-6-19(15-31-23)38-32-9-10-33-38/h2-11,13-15,22,35H,12H2,1H3,(H,34,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260666
PNG
(US9533985, 54)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H24F2N8O7S/c1-42-27-16-36-9-8-23(27)31(45)43(33(42)48)22-5-2-18(3-6-22)10-26(32(46)47)40-30(44)29-24(34)11-21(12-25(29)35)41-51(49,50)28-7-4-19(15-39-28)20-13-37-17-38-14-20/h2-9,11-17,26,41H,10H2,1H3,(H,40,44)(H,46,47)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260668
PNG
(US9533985, 56)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-9-8-24(39)38(28(36)43)18-4-2-16(3-5-18)10-22(27(41)42)34-26(40)25-20(29)11-17(12-21(25)30)35-46(44,45)23-7-6-19(13-32-23)37-15-31-14-33-37/h2-9,11-15,22,35H,10H2,1H3,(H,34,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260676
PNG
(US9533985, 64)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H25F2N5O7S/c1-36-15-12-27(39)38(31(36)43)22-6-4-19(5-7-22)16-26(30(41)42)34-29(40)28-24(32)17-20(18-25(28)33)35-46(44,45)23-10-8-21(9-11-23)37-13-2-3-14-37/h2-15,17-18,26,35H,16H2,1H3,(H,34,40)(H,41,42)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260688
PNG
(US9533985, 76)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5cccc5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C33H27F2N7O7S/c1-39-18-36-29-28(39)31(44)42(33(47)40(29)2)22-7-5-19(6-8-22)15-26(32(45)46)37-30(43)27-24(34)16-20(17-25(27)35)38-50(48,49)23-11-9-21(10-12-23)41-13-3-4-14-41/h3-14,16-18,26,38H,15H2,1-2H3,(H,37,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65398
PNG
(BDBM260664 | US9533985, 177)
Show SMILES CNCc1ccc(cc1)S(=O)(=O)Nc1ccc(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C32H29FN6O7S/c1-34-17-20-5-10-23(11-6-20)47(45,46)37-21-7-12-24(26(33)16-21)29(40)36-27(31(42)43)15-19-3-8-22(9-4-19)39-30(41)25-13-14-35-18-28(25)38(2)32(39)44/h3-14,16,18,27,34,37H,15,17H2,1-2H3,(H,36,40)(H,42,43)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65399
PNG
(US9533985, 178 | US9533985, 53)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccsc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O7S2/c1-40-29-17-37-12-10-25(29)32(43)41(34(40)46)23-6-2-19(3-7-23)14-28(33(44)45)38-31(42)30-26(35)15-22(16-27(30)36)39-50(47,48)24-8-4-20(5-9-24)21-11-13-49-18-21/h2-13,15-18,28,39H,14H2,1H3,(H,38,42)(H,44,45)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260671
PNG
(US9533985, 59)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4nccs4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H23F2N7O7S2/c1-40-25-16-35-9-8-21(25)30(43)41(32(40)46)20-5-2-17(3-6-20)12-24(31(44)45)38-28(42)27-22(33)13-19(14-23(27)34)39-50(47,48)26-7-4-18(15-37-26)29-36-10-11-49-29/h2-11,13-16,24,39H,12H2,1H3,(H,38,42)(H,44,45)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260687
PNG
(US9533985, 75)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-c5ccncc5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C34H27F2N7O7S/c1-41-18-38-30-29(41)32(45)43(34(48)42(30)2)23-7-3-19(4-8-23)15-27(33(46)47)39-31(44)28-25(35)16-22(17-26(28)36)40-51(49,50)24-9-5-20(6-10-24)21-11-13-37-14-12-21/h3-14,16-18,27,40H,15H2,1-2H3,(H,39,44)(H,46,47)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260667
PNG
(US9533985, 55)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-14-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)10-24(30(45)46)38-28(43)27-22(32)11-18(12-23(27)33)39-50(48,49)20-6-7-26(36-13-20)41-16-35-15-37-41/h2-9,11-16,24,39H,10H2,1H3,(H,38,43)(H,45,46)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260670
PNG
(US9533985, 58)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23F2N7O7S/c1-36-12-10-25(39)38(29(36)43)20-4-2-17(3-5-20)14-24(28(41)42)33-27(40)26-22(30)15-18(16-23(26)31)34-46(44,45)21-8-6-19(7-9-21)37-13-11-32-35-37/h2-13,15-16,24,34H,14H2,1H3,(H,33,40)(H,41,42)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260668
PNG
(US9533985, 56)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-9-8-24(39)38(28(36)43)18-4-2-16(3-5-18)10-22(27(41)42)34-26(40)25-20(29)11-17(12-21(25)30)35-46(44,45)23-7-6-19(13-32-23)37-15-31-14-33-37/h2-9,11-15,22,35H,10H2,1H3,(H,34,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260672
PNG
(US9533985, 60)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H24F2N6O7S/c1-38-11-10-27(40)39(31(38)44)22-6-2-18(3-7-22)12-26(30(42)43)36-29(41)28-24(32)13-21(14-25(28)33)37-47(45,46)23-8-4-19(5-9-23)20-15-34-17-35-16-20/h2-11,13-17,26,37H,12H2,1H3,(H,36,41)(H,42,43)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260653
PNG
(US9533985, 41)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N7O7S/c1-42-28-18-37-14-11-24(28)32(45)43(34(42)48)22-7-3-19(4-8-22)15-27(33(46)47)40-31(44)29-25(35)16-21(17-26(29)36)41-51(49,50)23-9-5-20(6-10-23)30-38-12-2-13-39-30/h2-14,16-18,27,41H,15H2,1H3,(H,40,44)(H,46,47)/t27-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260685
PNG
(US9533985, 73)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-10-8-24(39)38(28(36)43)18-4-2-16(3-5-18)12-22(27(41)42)33-26(40)25-20(29)13-17(14-21(25)30)34-46(44,45)23-7-6-19(15-31-23)37-11-9-32-35-37/h2-11,13-15,22,34H,12H2,1H3,(H,33,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260663
PNG
(US9533985, 51)
Show SMILES COc1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5ccnn5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C34H27F2N7O8S/c1-41-29-12-9-23(51-2)18-25(29)32(45)43(34(41)48)22-5-3-19(4-6-22)15-28(33(46)47)38-31(44)30-26(35)16-20(17-27(30)36)39-52(49,50)24-10-7-21(8-11-24)42-14-13-37-40-42/h3-14,16-18,28,39H,15H2,1-2H3,(H,38,44)(H,46,47)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260673
PNG
(US9533985, 61)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4nccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H24F2N8O7S/c1-40-27-17-35-11-10-23(27)30(44)41(32(40)47)20-4-2-18(3-5-20)14-26(31(45)46)38-29(43)28-24(33)15-19(16-25(28)34)39-50(48,49)22-8-6-21(7-9-22)42-36-12-13-37-42/h2-13,15-17,26,39H,14H2,1H3,(H,38,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65394
PNG
(US9533985, 159 | US9533985, 40)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-12-9-25(40)39(30(38)44)20-6-3-17(4-7-20)13-23(29(42)43)36-28(41)26-21(31)14-19(15-22(26)32)37-47(45,46)24-8-5-18(16-35-24)27-33-10-2-11-34-27/h2-12,14-16,23,37H,13H2,1H3,(H,36,41)(H,42,43)/t23-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260654
PNG
(US9533985, 42)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)-c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N7O7S/c1-42-29-18-38-13-10-24(29)32(45)43(34(42)48)22-4-2-19(3-5-22)14-28(33(46)47)40-31(44)30-25(35)15-21(16-26(30)36)41-51(49,50)23-6-7-27(39-17-23)20-8-11-37-12-9-20/h2-13,15-18,28,41H,14H2,1H3,(H,40,44)(H,46,47)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260689
PNG
(US9533985, 77)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-c5ncccn5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C33H26F2N8O7S/c1-41-17-38-29-27(41)31(45)43(33(48)42(29)2)21-8-4-18(5-9-21)14-25(32(46)47)39-30(44)26-23(34)15-20(16-24(26)35)40-51(49,50)22-10-6-19(7-11-22)28-36-12-3-13-37-28/h3-13,15-17,25,40H,14H2,1-2H3,(H,39,44)(H,46,47)/t25-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260677
PNG
(US9533985, 65)
Show SMILES Cc1cnccc1-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-18-39-13-11-26(20)22-5-9-25(10-6-22)52(50,51)42-23-16-28(37)32(29(38)17-23)33(45)41-30(35(47)48)15-21-3-7-24(8-4-21)44-34(46)27-12-14-40-19-31(27)43(2)36(44)49/h3-14,16-19,30,42H,15H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260680
PNG
(US9533985, 68)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccnc(F)c4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H25F3N6O7S/c1-43-29-18-39-12-11-25(29)33(46)44(35(43)49)23-6-2-19(3-7-23)14-28(34(47)48)41-32(45)31-26(36)16-22(17-27(31)37)42-52(50,51)24-8-4-20(5-9-24)21-10-13-40-30(38)15-21/h2-13,15-18,28,42H,14H2,1H3,(H,41,45)(H,47,48)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65401
PNG
(US9533985, 180)
Show SMILES Cc1cc(CNC(C)(C)C)ccc1S(=O)(=O)Nc1ccc(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H37FN6O7S/c1-21-16-23(19-39-36(2,3)4)8-13-31(21)51(49,50)41-24-9-12-26(28(37)18-24)32(44)40-29(34(46)47)17-22-6-10-25(11-7-22)43-33(45)27-14-15-38-20-30(27)42(5)35(43)48/h6-16,18,20,29,39,41H,17,19H2,1-5H3,(H,40,44)(H,46,47)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65374
PNG
(US9533985, 168)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC(C)(C)C)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H32F2N6O8S/c1-35(2,3)40-30(44)20-7-11-23(12-8-20)52(50,51)41-21-16-25(36)29(26(37)17-21)31(45)39-27(33(47)48)15-19-5-9-22(10-6-19)43-32(46)24-13-14-38-18-28(24)42(4)34(43)49/h5-14,16-18,27,41H,15H2,1-4H3,(H,39,45)(H,40,44)(H,47,48)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65395
PNG
(US9533985, 176)
Show SMILES CNCc1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)ccn(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C29H27F2N5O7S/c1-32-16-18-5-9-21(10-6-18)44(42,43)34-19-14-22(30)26(23(31)15-19)27(38)33-24(28(39)40)13-17-3-7-20(8-4-17)36-25(37)11-12-35(2)29(36)41/h3-12,14-15,24,32,34H,13,16H2,1-2H3,(H,33,38)(H,39,40)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65403
PNG
(US9533985, 143 | US9533985, 145)
Show SMILES COc1ccccc1S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C31H25F2N5O8S/c1-37-24-16-34-12-11-20(24)29(40)38(31(37)43)19-9-7-17(8-10-19)13-23(30(41)42)35-28(39)27-21(32)14-18(15-22(27)33)36-47(44,45)26-6-4-3-5-25(26)46-2/h3-12,14-16,23,36H,13H2,1-2H3,(H,35,39)(H,41,42)/t23-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65380
PNG
(US9533985, 170)
Show SMILES CCC(CC)NC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)ccn(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C33H33F2N5O8S/c1-4-21(5-2)36-30(42)20-8-12-24(13-9-20)49(47,48)38-22-17-25(34)29(26(35)18-22)31(43)37-27(32(44)45)16-19-6-10-23(11-7-19)40-28(41)14-15-39(3)33(40)46/h6-15,17-18,21,27,38H,4-5,16H2,1-3H3,(H,36,42)(H,37,43)(H,44,45)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65368
PNG
(US9533985, 153)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cn5)-c5ncccn5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C32H25F2N9O7S/c1-41-16-38-28-26(41)30(45)43(32(48)42(28)2)20-7-4-17(5-8-20)12-23(31(46)47)39-29(44)25-21(33)13-19(14-22(25)34)40-51(49,50)24-9-6-18(15-37-24)27-35-10-3-11-36-27/h3-11,13-16,23,40H,12H2,1-2H3,(H,39,44)(H,46,47)/t23-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65403
PNG
(US9533985, 143 | US9533985, 145)
Show SMILES COc1ccccc1S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C31H25F2N5O8S/c1-37-24-16-34-12-11-20(24)29(40)38(31(37)43)19-9-7-17(8-10-19)13-23(30(41)42)35-28(39)27-21(32)14-18(15-22(27)33)36-47(44,45)26-6-4-3-5-25(26)46-2/h3-12,14-16,23,36H,13H2,1-2H3,(H,35,39)(H,41,42)/t23-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


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More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65386
PNG
(US9533985, 172)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NCC4CCOCC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H33F2N5O9S/c1-40-13-10-29(42)41(34(40)47)24-6-2-20(3-7-24)16-28(33(45)46)38-32(44)30-26(35)17-23(18-27(30)36)39-51(48,49)25-8-4-22(5-9-25)31(43)37-19-21-11-14-50-15-12-21/h2-10,13,17-18,21,28,39H,11-12,14-16,19H2,1H3,(H,37,43)(H,38,44)(H,45,46)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65370
PNG
(US9533985, 165)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC4CCCC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H31F2N5O8S/c1-39-15-14-28(41)40(33(39)46)23-10-6-19(7-11-23)16-27(32(44)45)37-31(43)29-25(34)17-22(18-26(29)35)38-49(47,48)24-12-8-20(9-13-24)30(42)36-21-4-2-3-5-21/h6-15,17-18,21,27,38H,2-5,16H2,1H3,(H,36,42)(H,37,43)(H,44,45)/t27-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65367
PNG
(US9533985, 152)
Show SMILES CCNC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3ncn(C)c3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C32H29F2N7O8S/c1-4-35-28(42)18-7-11-21(12-8-18)50(48,49)38-19-14-22(33)25(23(34)15-19)29(43)37-24(31(45)46)13-17-5-9-20(10-6-17)41-30(44)26-27(36-16-39(26)2)40(3)32(41)47/h5-12,14-16,24,38H,4,13H2,1-3H3,(H,35,42)(H,37,43)(H,45,46)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65388
PNG
(US9533985, 173 | US9533985, 174)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)C(=O)NC(C)(C)C)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H30F2N6O8S/c1-31(2,3)36-27(41)23-10-9-20(16-34-23)48(46,47)37-18-14-21(32)26(22(33)15-18)28(42)35-24(29(43)44)13-17-5-7-19(8-6-17)39-25(40)11-12-38(4)30(39)45/h5-12,14-16,24,37H,13H2,1-4H3,(H,35,42)(H,36,41)(H,43,44)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65452
PNG
(US9533985, 238)
Show SMILES CCc1ncc(cn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(nc1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C35H28F2N8O7S/c1-3-30-39-16-21(17-40-30)20-5-7-22(8-6-20)53(51,52)43-27-14-25(36)24(13-26(27)37)32(46)42-28(34(48)49)12-19-4-9-31(41-15-19)45-33(47)23-10-11-38-18-29(23)44(2)35(45)50/h4-11,13-18,28,43H,3,12H2,1-2H3,(H,42,46)(H,48,49)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65441
PNG
(US9533985, 231)
Show SMILES CCOc1cc(ccc1S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cn2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1)-c1ncccn1
Show InChI InChI=1S/C35H28F2N8O8S/c1-3-53-28-13-19(31-39-10-4-11-40-31)5-8-29(28)54(51,52)43-21-14-24(36)30(25(37)15-21)32(46)42-26(34(48)49)16-20-6-7-22(17-41-20)45-33(47)23-9-12-38-18-27(23)44(2)35(45)50/h4-15,17-18,26,43H,3,16H2,1-2H3,(H,42,46)(H,48,49)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65400
PNG
(US9533985, 179)
Show SMILES Cn1c2c[n+]([O-])ccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4cc[n+]([O-])cc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23FN6O9S/c1-33-25-16-35(43)13-10-22(25)27(38)36(29(33)41)19-5-2-17(3-6-19)14-24(28(39)40)31-26(37)21-7-4-18(15-23(21)30)32-46(44,45)20-8-11-34(42)12-9-20/h2-13,15-16,24,32H,14H2,1H3,(H,31,37)(H,39,40)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65389
PNG
(US9533985, 158)
Show SMILES Cc1cc(ccc1S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)ccn(C)c2=O)C(O)=O)c(F)c1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C33H33F2N5O8S/c1-18-14-20(29(42)37-33(2,3)4)8-11-26(18)49(47,48)38-21-16-23(34)28(24(35)17-21)30(43)36-25(31(44)45)15-19-6-9-22(10-7-19)40-27(41)12-13-39(5)32(40)46/h6-14,16-17,25,38H,15H2,1-5H3,(H,36,43)(H,37,42)(H,44,45)/t25-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65373
PNG
(US9533985, 167)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC(C)(C)C)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H31F2N5O8S/c1-32(2,3)36-28(41)19-7-11-22(12-8-19)48(46,47)37-20-16-23(33)27(24(34)17-20)29(42)35-25(30(43)44)15-18-5-9-21(10-6-18)39-26(40)13-14-38(4)31(39)45/h5-14,16-17,25,37H,15H2,1-4H3,(H,35,42)(H,36,41)(H,43,44)/t25-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260675
PNG
(US9533985, 63)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-9-8-26(40)39(30(38)44)21-5-2-17(3-6-21)10-24(29(42)43)36-28(41)27-22(31)11-20(12-23(27)32)37-47(45,46)25-7-4-18(15-35-25)19-13-33-16-34-14-19/h2-9,11-16,24,37H,10H2,1H3,(H,36,41)(H,42,43)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260679
PNG
(US9533985, 67)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H26F2N6O7S/c1-42-30-19-39-15-12-26(30)33(45)43(35(42)48)24-6-2-20(3-7-24)16-29(34(46)47)40-32(44)31-27(36)17-23(18-28(31)37)41-51(49,50)25-8-4-21(5-9-25)22-10-13-38-14-11-22/h2-15,17-19,29,41H,16H2,1H3,(H,40,44)(H,46,47)/t29-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260686
PNG
(US9533985, 74)
Show SMILES Cc1cc(ccn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3ncn(C)c3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C35H29F2N7O7S/c1-19-14-22(12-13-38-19)21-6-10-25(11-7-21)52(50,51)41-23-16-26(36)29(27(37)17-23)32(45)40-28(34(47)48)15-20-4-8-24(9-5-20)44-33(46)30-31(39-18-42(30)2)43(3)35(44)49/h4-14,16-18,28,41H,15H2,1-3H3,(H,40,45)(H,47,48)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260655
PNG
(US9533985, 43)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H26F2N6O7S/c1-40-29-19-37-13-12-25(29)32(44)42(34(40)47)23-6-4-20(5-7-23)16-28(33(45)46)38-31(43)30-26(35)17-21(18-27(30)36)39-50(48,49)24-10-8-22(9-11-24)41-14-2-3-15-41/h2-15,17-19,28,39H,16H2,1H3,(H,38,43)(H,45,46)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260669
PNG
(US9533985, 57)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-14-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)10-24(30(45)46)38-28(43)27-22(32)11-18(12-23(27)33)39-50(48,49)26-7-6-20(13-36-26)41-16-35-15-37-41/h2-9,11-16,24,39H,10H2,1H3,(H,38,43)(H,45,46)/t24-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


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More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65398
PNG
(BDBM260664 | US9533985, 177)
Show SMILES CNCc1ccc(cc1)S(=O)(=O)Nc1ccc(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C32H29FN6O7S/c1-34-17-20-5-10-23(11-6-20)47(45,46)37-21-7-12-24(26(33)16-21)29(40)36-27(31(42)43)15-19-3-8-22(9-4-19)39-30(41)25-13-14-35-18-28(25)38(2)32(39)44/h3-14,16,18,27,34,37H,15,17H2,1-2H3,(H,36,40)(H,42,43)/t27-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260674
PNG
(US9533985, 62)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25F2N7O7S/c1-40-28-18-36-13-11-24(28)31(44)42(33(40)47)22-5-3-19(4-6-22)15-27(32(45)46)38-30(43)29-25(34)16-20(17-26(29)35)39-50(48,49)23-9-7-21(8-10-23)41-14-2-12-37-41/h2-14,16-18,27,39H,15H2,1H3,(H,38,43)(H,45,46)/t27-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260660
PNG
(US9533985, 48)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncc[nH]4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25F2N7O7S/c1-41-27-17-36-11-10-23(27)31(44)42(33(41)47)21-6-2-18(3-7-21)14-26(32(45)46)39-30(43)28-24(34)15-20(16-25(28)35)40-50(48,49)22-8-4-19(5-9-22)29-37-12-13-38-29/h2-13,15-17,26,40H,14H2,1H3,(H,37,38)(H,39,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260658
PNG
(US9533985, 46)
Show SMILES COc1cc2c(cn1)n(C)c(=O)n(-c1ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncccn4)cc3F)C(O)=O)cc1)c2=O
Show InChI InChI=1S/C35H27F2N7O8S/c1-43-28-18-40-29(52-2)17-24(28)33(46)44(35(43)49)22-8-4-19(5-9-22)14-27(34(47)48)41-32(45)30-25(36)15-21(16-26(30)37)42-53(50,51)23-10-6-20(7-11-23)31-38-12-3-13-39-31/h3-13,15-18,27,42H,14H2,1-2H3,(H,41,45)(H,47,48)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260656
PNG
(US9533985, 44)
Show SMILES CCNC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)ccn(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C30H27F2N5O8S/c1-3-33-27(39)18-6-10-21(11-7-18)46(44,45)35-19-15-22(31)26(23(32)16-19)28(40)34-24(29(41)42)14-17-4-8-20(9-5-17)37-25(38)12-13-36(2)30(37)43/h4-13,15-16,24,35H,3,14H2,1-2H3,(H,33,39)(H,34,40)(H,41,42)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260666
PNG
(US9533985, 54)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H24F2N8O7S/c1-42-27-16-36-9-8-23(27)31(45)43(33(42)48)22-5-2-18(3-6-22)10-26(32(46)47)40-30(44)29-24(34)11-21(12-25(29)35)41-51(49,50)28-7-4-19(15-39-28)20-13-37-17-38-14-20/h2-9,11-17,26,41H,10H2,1H3,(H,40,44)(H,46,47)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260662
PNG
(US9533985, 50)
Show SMILES Cc1ccc(cn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-3-6-23(18-40-20)22-7-11-26(12-8-22)52(50,51)42-24-16-28(37)32(29(38)17-24)33(45)41-30(35(47)48)15-21-4-9-25(10-5-21)44-34(46)27-13-14-39-19-31(27)43(2)36(44)49/h3-14,16-19,30,42H,15H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260690
PNG
(US9533985, 78)
Show SMILES COc1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)C(=O)NC5CC5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C36H31F2N5O9S/c1-42-30-14-11-24(52-2)18-26(30)34(46)43(36(42)49)23-9-3-19(4-10-23)15-29(35(47)48)40-33(45)31-27(37)16-22(17-28(31)38)41-53(50,51)25-12-5-20(6-13-25)32(44)39-21-7-8-21/h3-6,9-14,16-18,21,29,41H,7-8,15H2,1-2H3,(H,39,44)(H,40,45)(H,47,48)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260659
PNG
(US9533985, 47)
Show SMILES CN(C)c1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5cncn5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C35H30F2N8O7S/c1-42(2)24-10-13-30-26(17-24)33(47)45(35(50)43(30)3)23-6-4-20(5-7-23)14-29(34(48)49)40-32(46)31-27(36)15-21(16-28(31)37)41-53(51,52)25-11-8-22(9-12-25)44-19-38-18-39-44/h4-13,15-19,29,41H,14H2,1-3H3,(H,40,46)(H,48,49)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65383
PNG
(BDBM260657 | US9533985, 157)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC4CC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H27F2N5O8S/c1-37-13-12-26(39)38(31(37)44)21-8-2-17(3-9-21)14-25(30(42)43)35-29(41)27-23(32)15-20(16-24(27)33)36-47(45,46)22-10-4-18(5-11-22)28(40)34-19-6-7-19/h2-5,8-13,15-16,19,25,36H,6-7,14H2,1H3,(H,34,40)(H,35,41)(H,42,43)/t25-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260682
PNG
(US9533985, 70)
Show SMILES Cc1cc(cc(C)n1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C37H30F2N6O7S/c1-20-14-24(15-21(2)41-20)23-6-10-27(11-7-23)53(51,52)43-25-17-29(38)33(30(39)18-25)34(46)42-31(36(48)49)16-22-4-8-26(9-5-22)45-35(47)28-12-13-40-19-32(28)44(3)37(45)50/h4-15,17-19,31,43H,16H2,1-3H3,(H,42,46)(H,48,49)/t31-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260663
PNG
(US9533985, 51)
Show SMILES COc1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5ccnn5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C34H27F2N7O8S/c1-41-29-12-9-23(51-2)18-25(29)32(45)43(34(41)48)22-5-3-19(4-6-22)15-28(33(46)47)38-31(44)30-26(35)16-20(17-27(30)36)39-52(49,50)24-10-7-21(8-11-24)42-14-13-37-40-42/h3-14,16-18,28,39H,15H2,1-2H3,(H,38,44)(H,46,47)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260688
PNG
(US9533985, 76)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5cccc5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C33H27F2N7O7S/c1-39-18-36-29-28(39)31(44)42(33(47)40(29)2)22-7-5-19(6-8-22)15-26(32(45)46)37-30(43)27-24(34)16-20(17-25(27)35)38-50(48,49)23-11-9-21(10-12-23)41-13-3-4-14-41/h3-14,16-18,26,38H,15H2,1-2H3,(H,37,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260671
PNG
(US9533985, 59)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4nccs4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H23F2N7O7S2/c1-40-25-16-35-9-8-21(25)30(43)41(32(40)46)20-5-2-17(3-6-20)12-24(31(44)45)38-28(42)27-22(33)13-19(14-23(27)34)39-50(47,48)26-7-4-18(15-37-26)29-36-10-11-49-29/h2-11,13-16,24,39H,12H2,1H3,(H,38,42)(H,44,45)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260683
PNG
(US9533985, 71)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-16-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)12-24(30(45)46)37-28(43)27-22(32)13-18(14-23(27)33)38-50(48,49)26-7-6-20(15-35-26)41-11-10-36-39-41/h2-11,13-16,24,38H,12H2,1H3,(H,37,43)(H,45,46)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260676
PNG
(US9533985, 64)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H25F2N5O7S/c1-36-15-12-27(39)38(31(36)43)22-6-4-19(5-7-22)16-26(30(41)42)34-29(40)28-24(32)17-20(18-25(28)33)35-46(44,45)23-10-8-21(9-11-23)37-13-2-3-14-37/h2-15,17-18,26,35H,16H2,1H3,(H,34,40)(H,41,42)/t26-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260684
PNG
(US9533985, 72)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4nccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-11-8-24(39)37(28(36)43)18-4-2-16(3-5-18)12-22(27(41)42)34-26(40)25-20(29)13-17(14-21(25)30)35-46(44,45)23-7-6-19(15-31-23)38-32-9-10-33-38/h2-11,13-15,22,35H,12H2,1H3,(H,34,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260678
PNG
(US9533985, 66)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccoc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O8S/c1-40-29-17-37-12-10-25(29)32(43)41(34(40)46)23-6-2-19(3-7-23)14-28(33(44)45)38-31(42)30-26(35)15-22(16-27(30)36)39-50(47,48)24-8-4-20(5-9-24)21-11-13-49-18-21/h2-13,15-18,28,39H,14H2,1H3,(H,38,42)(H,44,45)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65399
PNG
(US9533985, 178 | US9533985, 53)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccsc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O7S2/c1-40-29-17-37-12-10-25(29)32(43)41(34(40)46)23-6-2-19(3-7-23)14-28(33(44)45)38-31(42)30-26(35)15-22(16-27(30)36)39-50(47,48)24-8-4-20(5-9-24)21-11-13-49-18-21/h2-13,15-18,28,39H,14H2,1H3,(H,38,42)(H,44,45)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260661
PNG
(US9533985, 49)
Show SMILES Cc1cc(ccn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-15-23(11-14-40-20)22-5-9-26(10-6-22)52(50,51)42-24-17-28(37)32(29(38)18-24)33(45)41-30(35(47)48)16-21-3-7-25(8-4-21)44-34(46)27-12-13-39-19-31(27)43(2)36(44)49/h3-15,17-19,30,42H,16H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM260651
PNG
(US9533985, 39)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23FN6O7S/c1-35-25-16-32-13-10-22(25)27(38)36(29(35)41)19-5-2-17(3-6-19)14-24(28(39)40)33-26(37)21-7-4-18(15-23(21)30)34-44(42,43)20-8-11-31-12-9-20/h2-13,15-16,24,34H,14H2,1H3,(H,33,37)(H,39,40)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260681
PNG
(US9533985, 69)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C4=CCNCC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H30F2N6O7S/c1-42-30-19-39-15-12-26(30)33(45)43(35(42)48)24-6-2-20(3-7-24)16-29(34(46)47)40-32(44)31-27(36)17-23(18-28(31)37)41-51(49,50)25-8-4-21(5-9-25)22-10-13-38-14-11-22/h2-10,12,15,17-19,29,38,41H,11,13-14,16H2,1H3,(H,40,44)(H,46,47)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260667
PNG
(US9533985, 55)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-25-14-34-9-8-21(25)29(44)42(31(40)47)19-4-2-17(3-5-19)10-24(30(45)46)38-28(43)27-22(32)11-18(12-23(27)33)39-50(48,49)20-6-7-26(36-13-20)41-16-35-15-37-41/h2-9,11-16,24,39H,10H2,1H3,(H,38,43)(H,45,46)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65382
PNG
(US9533985, 156)
Show SMILES CCNC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)cc(C(C)C)n(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C33H33F2N5O8S/c1-5-36-30(42)20-8-12-23(13-9-20)49(47,48)38-21-15-24(34)29(25(35)16-21)31(43)37-26(32(44)45)14-19-6-10-22(11-7-19)40-28(41)17-27(18(2)3)39(4)33(40)46/h6-13,15-18,26,38H,5,14H2,1-4H3,(H,36,42)(H,37,43)(H,44,45)/t26-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65432
PNG
(US9533985, 219)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-n4cnnc4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-27-14-34-9-8-21(27)29(44)42(31(40)47)19-3-2-17(35-13-19)10-26(30(45)46)38-28(43)22-11-24(33)25(12-23(22)32)39-50(48,49)20-6-4-18(5-7-20)41-15-36-37-16-41/h2-9,11-16,26,39H,10H2,1H3,(H,38,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65434
PNG
(US9533985, 221)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-n4cncn4)cc3F)C(O)=O)cn2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-26-14-34-9-8-20(26)29(44)42(31(40)47)27-7-2-17(13-36-27)10-25(30(45)46)38-28(43)21-11-23(33)24(12-22(21)32)39-50(48,49)19-5-3-18(4-6-19)41-16-35-15-37-41/h2-9,11-16,25,39H,10H2,1H3,(H,38,43)(H,45,46)/t25-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65399
PNG
(US9533985, 178 | US9533985, 53)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccsc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O7S2/c1-40-29-17-37-12-10-25(29)32(43)41(34(40)46)23-6-2-19(3-7-23)14-28(33(44)45)38-31(42)30-26(35)15-22(16-27(30)36)39-50(47,48)24-8-4-20(5-9-24)21-11-13-49-18-21/h2-13,15-18,28,39H,14H2,1H3,(H,38,42)(H,44,45)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65417
PNG
(US9533985, 150)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccco4)cc3F)C(O)=O)cn2)c1=O
Show InChI InChI=1S/C27H20F2N6O8S/c1-34-21-13-30-7-6-15(21)25(37)35(27(34)40)22-5-4-14(12-31-22)9-20(26(38)39)32-24(36)16-10-18(29)19(11-17(16)28)33-44(41,42)23-3-2-8-43-23/h2-8,10-13,20,33H,9H2,1H3,(H,32,36)(H,38,39)/t20-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65429
PNG
(US9533985, 215 | US9533985, 220)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C32H23F2N9O7S/c1-42-27-15-35-7-6-21(27)30(45)43(32(42)48)20-4-3-19(38-14-20)8-26(31(46)47)40-29(44)22-9-24(34)25(10-23(22)33)41-51(49,50)28-5-2-17(13-39-28)18-11-36-16-37-12-18/h2-7,9-16,26,41H,8H2,1H3,(H,40,44)(H,46,47)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65430
PNG
(US9533985, 216)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-9-8-27(40)39(30(38)44)20-5-2-17(3-6-20)10-25(29(42)43)36-28(41)21-11-23(32)24(12-22(21)31)37-47(45,46)26-7-4-18(15-35-26)19-13-33-16-34-14-19/h2-9,11-16,25,37H,10H2,1H3,(H,36,41)(H,42,43)/t25-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65429
PNG
(US9533985, 215 | US9533985, 220)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C32H23F2N9O7S/c1-42-27-15-35-7-6-21(27)30(45)43(32(42)48)20-4-3-19(38-14-20)8-26(31(46)47)40-29(44)22-9-24(34)25(10-23(22)33)41-51(49,50)28-5-2-17(13-39-28)18-11-36-16-37-12-18/h2-7,9-16,26,41H,8H2,1H3,(H,40,44)(H,46,47)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65450
PNG
(US9533985, 236)
Show SMILES CCc1ncc(cn1)-c1ccc(nc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(cn1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C34H27F2N9O7S/c1-3-29-39-14-19(15-40-29)18-4-7-30(41-13-18)53(51,52)43-26-12-24(35)23(11-25(26)36)31(46)42-27(33(48)49)10-20-5-6-21(16-38-20)45-32(47)22-8-9-37-17-28(22)44(2)34(45)50/h4-9,11-17,27,43H,3,10H2,1-2H3,(H,42,46)(H,48,49)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65366
PNG
(US9533985, 163)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25FN8O7S/c1-41-28-17-35-11-10-25(28)31(44)42(33(41)47)23-6-2-19(3-7-23)12-27(32(45)46)39-30(43)24-8-5-22(13-26(24)34)40-50(48,49)29-9-4-20(16-38-29)21-14-36-18-37-15-21/h2-11,13-18,27,40H,12H2,1H3,(H,39,43)(H,45,46)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65415
PNG
(US9533985, 141)
Show SMILES CC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(cc1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C32H25F2N5O8S/c1-17(40)19-5-9-21(10-6-19)48(46,47)37-26-15-24(33)23(14-25(26)34)29(41)36-27(31(43)44)13-18-3-7-20(8-4-18)39-30(42)22-11-12-35-16-28(22)38(2)32(39)45/h3-12,14-16,27,37H,13H2,1-2H3,(H,36,41)(H,43,44)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65428
PNG
(US9533985, 217)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cn4)-n4cncn4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C30H22F2N10O7S/c1-40-25-13-33-7-6-19(25)28(44)42(30(40)47)18-3-2-16(35-12-18)8-24(29(45)46)38-27(43)20-9-22(32)23(10-21(20)31)39-50(48,49)26-5-4-17(11-36-26)41-15-34-14-37-41/h2-7,9-15,24,39H,8H2,1H3,(H,38,43)(H,45,46)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65381
PNG
(US9533985, 155)
Show SMILES CCNC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)cc(C)n(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C31H29F2N5O8S/c1-4-34-28(40)19-7-11-22(12-8-19)47(45,46)36-20-15-23(32)27(24(33)16-20)29(41)35-25(30(42)43)14-18-5-9-21(10-6-18)38-26(39)13-17(2)37(3)31(38)44/h5-13,15-16,25,36H,4,14H2,1-3H3,(H,34,40)(H,35,41)(H,42,43)/t25-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65384
PNG
(US9533985, 142)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23FN6O7S/c1-35-24-16-31-13-11-21(24)27(38)36(29(35)41)19-8-5-17(6-9-19)14-23(28(39)40)33-26(37)20-10-7-18(15-22(20)30)34-44(42,43)25-4-2-3-12-32-25/h2-13,15-16,23,34H,14H2,1H3,(H,33,37)(H,39,40)/t23-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65369
PNG
(US9533985, 164)
Show SMILES CCNC(=O)c1ccc(cn1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)ccn(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C29H26F2N6O8S/c1-3-32-26(39)22-9-8-19(15-33-22)46(44,45)35-17-13-20(30)25(21(31)14-17)27(40)34-23(28(41)42)12-16-4-6-18(7-5-16)37-24(38)10-11-36(2)29(37)43/h4-11,13-15,23,35H,3,12H2,1-2H3,(H,32,39)(H,34,40)(H,41,42)/t23-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65371
PNG
(US9533985, 166)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC4CCCC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C36H32F2N6O8S/c1-43-30-19-39-15-14-26(30)34(47)44(36(43)50)24-10-6-20(7-11-24)16-29(35(48)49)41-33(46)31-27(37)17-23(18-28(31)38)42-53(51,52)25-12-8-21(9-13-25)32(45)40-22-4-2-3-5-22/h6-15,17-19,22,29,42H,2-5,16H2,1H3,(H,40,45)(H,41,46)(H,48,49)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65379
PNG
(US9533985, 169)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC4CCCCC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H33F2N5O8S/c1-40-16-15-29(42)41(34(40)47)24-11-7-20(8-12-24)17-28(33(45)46)38-32(44)30-26(35)18-23(19-27(30)36)39-50(48,49)25-13-9-21(10-14-25)31(43)37-22-5-3-2-4-6-22/h7-16,18-19,22,28,39H,2-6,17H2,1H3,(H,37,43)(H,38,44)(H,45,46)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65412
PNG
(US9533985, 185)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccccc4O)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N5O8S/c1-36-23-15-33-11-10-19(23)28(40)37(30(36)43)18-8-6-16(7-9-18)12-22(29(41)42)34-27(39)26-20(31)13-17(14-21(26)32)35-46(44,45)25-5-3-2-4-24(25)38/h2-11,13-15,22,35,38H,12H2,1H3,(H,34,39)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65414
PNG
(US9533985, 140 | US9533985, 149)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccco4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H21F2N5O8S/c1-34-23-14-31-9-8-17(23)26(37)35(28(34)40)16-6-4-15(5-7-16)11-22(27(38)39)32-25(36)18-12-20(30)21(13-19(18)29)33-44(41,42)24-3-2-10-43-24/h2-10,12-14,22,33H,11H2,1H3,(H,32,36)(H,38,39)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65414
PNG
(US9533985, 140 | US9533985, 149)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccco4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H21F2N5O8S/c1-34-23-14-31-9-8-17(23)26(37)35(28(34)40)16-6-4-15(5-7-16)11-22(27(38)39)32-25(36)18-12-20(30)21(13-19(18)29)33-44(41,42)24-3-2-10-43-24/h2-10,12-14,22,33H,11H2,1H3,(H,32,36)(H,38,39)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65419
PNG
(US9533985, 213)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4cccs4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H21F2N5O7S2/c1-34-23-14-31-9-8-17(23)26(37)35(28(34)40)16-6-4-15(5-7-16)11-22(27(38)39)32-25(36)18-12-20(30)21(13-19(18)29)33-44(41,42)24-3-2-10-43-24/h2-10,12-14,22,33H,11H2,1H3,(H,32,36)(H,38,39)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65413
PNG
(US9533985, 146 | US9533985, 214)
Show SMILES CCOc1ccccc1S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C32H27F2N5O8S/c1-3-47-26-6-4-5-7-27(26)48(45,46)37-19-15-22(33)28(23(34)16-19)29(40)36-24(31(42)43)14-18-8-10-20(11-9-18)39-30(41)21-12-13-35-17-25(21)38(2)32(39)44/h4-13,15-17,24,37H,3,14H2,1-2H3,(H,36,40)(H,42,43)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65426
PNG
(US9533985, 225)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H24F2N8O7S/c1-40-28-15-35-11-10-22(28)30(44)42(32(40)47)20-4-2-18(3-5-20)12-27(31(45)46)38-29(43)23-13-25(34)26(14-24(23)33)39-50(48,49)21-8-6-19(7-9-21)41-17-36-16-37-41/h2-11,13-17,27,39H,12H2,1H3,(H,38,43)(H,45,46)/t27-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65448
PNG
(US9533985, 234)
Show SMILES Cc1cn(nn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(cn1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C32H25F2N9O7S/c1-17-16-42(40-38-17)19-5-7-21(8-6-19)51(49,50)39-26-13-24(33)23(12-25(26)34)29(44)37-27(31(46)47)11-18-3-4-20(14-36-18)43-30(45)22-9-10-35-15-28(22)41(2)32(43)48/h3-10,12-16,27,39H,11H2,1-2H3,(H,37,44)(H,46,47)/t27-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65385
PNG
(US9533985, 171)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C26H21F2N5O7S/c1-32-11-8-22(34)33(26(32)38)17-4-2-15(3-5-17)12-21(25(36)37)30-24(35)23-19(27)13-16(14-20(23)28)31-41(39,40)18-6-9-29-10-7-18/h2-11,13-14,21,31H,12H2,1H3,(H,30,35)(H,36,37)/t21-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65391
PNG
(US9533985, 175)
Show SMILES Cc1cn(C)c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)C(=O)NC(C)(C)C)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H32F2N6O8S/c1-17-16-39(5)31(46)40(29(17)43)20-8-6-18(7-9-20)12-25(30(44)45)36-28(42)26-22(33)13-19(14-23(26)34)38-49(47,48)21-10-11-24(35-15-21)27(41)37-32(2,3)4/h6-11,13-16,25,38H,12H2,1-5H3,(H,36,42)(H,37,41)(H,44,45)/t25-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65392
PNG
(US9533985, 139)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccco4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22FN5O8S/c1-33-23-15-30-11-10-20(23)26(36)34(28(33)39)18-7-4-16(5-8-18)13-22(27(37)38)31-25(35)19-9-6-17(14-21(19)29)32-43(40,41)24-3-2-12-42-24/h2-12,14-15,22,32H,13H2,1H3,(H,31,35)(H,37,38)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65398
PNG
(BDBM260664 | US9533985, 177)
Show SMILES CNCc1ccc(cc1)S(=O)(=O)Nc1ccc(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C32H29FN6O7S/c1-34-17-20-5-10-23(11-6-20)47(45,46)37-21-7-12-24(26(33)16-21)29(40)36-27(31(42)43)15-19-3-8-22(9-4-19)39-30(41)25-13-14-35-18-28(25)38(2)32(39)44/h3-14,16,18,27,34,37H,15,17H2,1-2H3,(H,36,40)(H,42,43)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65376
PNG
(US9533985, 151)
Show SMILES Cc1ccc(cn1)-c1ccc(nc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C35H27F2N7O7S/c1-19-3-6-21(16-39-19)22-7-10-30(40-17-22)52(50,51)42-23-14-26(36)31(27(37)15-23)32(45)41-28(34(47)48)13-20-4-8-24(9-5-20)44-33(46)25-11-12-38-18-29(25)43(2)35(44)49/h3-12,14-18,28,42H,13H2,1-2H3,(H,41,45)(H,47,48)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65409
PNG
(US9533985, 183)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ncc(NS(=O)(=O)c4ccco4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C27H21FN6O8S/c1-33-21-14-29-9-8-18(21)25(36)34(27(33)39)17-6-4-15(5-7-17)11-20(26(37)38)31-24(35)23-19(28)12-16(13-30-23)32-43(40,41)22-3-2-10-42-22/h2-10,12-14,20,32H,11H2,1H3,(H,31,35)(H,37,38)/t20-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65410
PNG
(US9533985, 184)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ncc(NS(=O)(=O)c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22FN7O7S/c1-35-23-15-31-11-8-20(23)26(38)36(28(35)41)18-4-2-16(3-5-18)12-22(27(39)40)33-25(37)24-21(29)13-17(14-32-24)34-44(42,43)19-6-9-30-10-7-19/h2-11,13-15,22,34H,12H2,1H3,(H,33,37)(H,39,40)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65431
PNG
(US9533985, 218)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-n4cnnn4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C30H22F2N10O7S/c1-40-26-14-33-9-8-20(26)28(44)42(30(40)47)18-3-2-16(34-13-18)10-25(29(45)46)36-27(43)21-11-23(32)24(12-22(21)31)37-50(48,49)19-6-4-17(5-7-19)41-15-35-38-39-41/h2-9,11-15,25,37H,10H2,1H3,(H,36,43)(H,45,46)/t25-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65451
PNG
(US9533985, 237)
Show SMILES CCc1ncc(cn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(cc1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C36H29F2N7O7S/c1-3-32-40-17-22(18-41-32)21-6-10-24(11-7-21)53(51,52)43-29-16-27(37)26(15-28(29)38)33(46)42-30(35(48)49)14-20-4-8-23(9-5-20)45-34(47)25-12-13-39-19-31(25)44(2)36(45)50/h4-13,15-19,30,43H,3,14H2,1-2H3,(H,42,46)(H,48,49)/t30-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65383
PNG
(BDBM260657 | US9533985, 157)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC4CC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H27F2N5O8S/c1-37-13-12-26(39)38(31(37)44)21-8-2-17(3-9-21)14-25(30(42)43)35-29(41)27-23(32)15-20(16-24(27)33)36-47(45,46)22-10-4-18(5-11-22)28(40)34-19-6-7-19/h2-5,8-13,15-16,19,25,36H,6-7,14H2,1H3,(H,34,40)(H,35,41)(H,42,43)/t25-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65394
PNG
(US9533985, 159 | US9533985, 40)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-12-9-25(40)39(30(38)44)20-6-3-17(4-7-20)13-23(29(42)43)36-28(41)26-21(31)14-19(15-22(26)32)37-47(45,46)24-8-5-18(16-35-24)27-33-10-2-11-34-27/h2-12,14-16,23,37H,13H2,1H3,(H,36,41)(H,42,43)/t23-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65364
PNG
(US9533985, 162)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4cccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H24F2N6O7S/c1-36-13-10-26(39)38(30(36)43)20-6-4-18(5-7-20)14-24(29(41)42)34-28(40)27-22(31)15-19(16-23(27)32)35-46(44,45)25-9-8-21(17-33-25)37-11-2-3-12-37/h2-13,15-17,24,35H,14H2,1H3,(H,34,40)(H,41,42)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65377
PNG
(US9533985, 154)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccc(cn4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25FN8O7S/c1-41-27-18-35-14-11-24(27)31(44)42(33(41)47)22-7-3-19(4-8-22)15-26(32(45)46)39-30(43)23-9-6-21(16-25(23)34)40-50(48,49)28-10-5-20(17-38-28)29-36-12-2-13-37-29/h2-14,16-18,26,40H,15H2,1H3,(H,39,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65406
PNG
(US9533985, 148)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccco4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O8S/c1-40-28-18-37-13-12-24(28)32(43)41(34(40)46)22-8-4-19(5-9-22)15-27(33(44)45)38-31(42)30-25(35)16-21(17-26(30)36)39-50(47,48)23-10-6-20(7-11-23)29-3-2-14-49-29/h2-14,16-18,27,39H,15H2,1H3,(H,38,42)(H,44,45)/t27-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65407
PNG
(US9533985, 182)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccc[nH]4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H23FN6O7S/c1-34-23-15-30-12-10-20(23)26(37)35(28(34)40)18-7-4-16(5-8-18)13-22(27(38)39)32-25(36)19-9-6-17(14-21(19)29)33-43(41,42)24-3-2-11-31-24/h2-12,14-15,22,31,33H,13H2,1H3,(H,32,36)(H,38,39)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65425
PNG
(US9533985, 224)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-n4cncn4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-27-14-34-9-8-21(27)29(44)42(31(40)47)19-3-2-17(36-13-19)10-26(30(45)46)38-28(43)22-11-24(33)25(12-23(22)32)39-50(48,49)20-6-4-18(5-7-20)41-16-35-15-37-41/h2-9,11-16,26,39H,10H2,1H3,(H,38,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65388
PNG
(US9533985, 173 | US9533985, 174)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)C(=O)NC(C)(C)C)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H30F2N6O8S/c1-31(2,3)36-27(41)23-10-9-20(16-34-23)48(46,47)37-18-14-21(32)26(22(33)15-18)28(42)35-24(29(43)44)13-17-5-7-19(8-6-17)39-25(40)11-12-38(4)30(39)45/h5-12,14-16,24,37H,13H2,1-4H3,(H,35,42)(H,36,41)(H,43,44)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65404
PNG
(US9533985, 147)
Show SMILES COc1cc2c(cn1)n(C)c(=O)n(-c1ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccco4)cc3F)C(O)=O)cc1)c2=O
Show InChI InChI=1S/C29H24FN5O9S/c1-34-23-15-31-24(43-2)14-20(23)27(37)35(29(34)40)18-8-5-16(6-9-18)12-22(28(38)39)32-26(36)19-10-7-17(13-21(19)30)33-45(41,42)25-4-3-11-44-25/h3-11,13-15,22,33H,12H2,1-2H3,(H,32,36)(H,38,39)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65413
PNG
(US9533985, 146 | US9533985, 214)
Show SMILES CCOc1ccccc1S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C32H27F2N5O8S/c1-3-47-26-6-4-5-7-27(26)48(45,46)37-19-15-22(33)28(23(34)16-19)29(40)36-24(31(42)43)14-18-8-10-20(11-9-18)39-30(41)21-12-13-35-17-25(21)38(2)32(39)44/h4-13,15-17,24,37H,3,14H2,1-2H3,(H,36,40)(H,42,43)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65427
PNG
(US9533985, 226)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-n4ccnn4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C31H23F2N9O7S/c1-40-27-16-34-9-8-21(27)29(44)42(31(40)47)19-3-2-17(35-15-19)12-26(30(45)46)37-28(43)22-13-24(33)25(14-23(22)32)38-50(48,49)20-6-4-18(5-7-20)41-11-10-36-39-41/h2-11,13-16,26,38H,12H2,1H3,(H,37,43)(H,45,46)/t26-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65402
PNG
(US9533985, 181)
Show SMILES Cc1cc(CNC2CCCC2)ccc1S(=O)(=O)Nc1ccc(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C37H37FN6O7S/c1-22-17-24(20-40-25-5-3-4-6-25)9-14-33(22)52(50,51)42-26-10-13-28(30(38)19-26)34(45)41-31(36(47)48)18-23-7-11-27(12-8-23)44-35(46)29-15-16-39-21-32(29)43(2)37(44)49/h7-17,19,21,25,31,40,42H,3-6,18,20H2,1-2H3,(H,41,45)(H,47,48)/t31-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260654
PNG
(US9533985, 42)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(nc4)-c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N7O7S/c1-42-29-18-38-13-10-24(29)32(45)43(34(42)48)22-4-2-19(3-5-22)14-28(33(46)47)40-31(44)30-25(35)15-21(16-26(30)36)41-51(49,50)23-6-7-27(39-17-23)20-8-11-37-12-9-20/h2-13,15-18,28,41H,14H2,1H3,(H,40,44)(H,46,47)/t28-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260660
PNG
(US9533985, 48)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncc[nH]4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25F2N7O7S/c1-41-27-17-36-11-10-23(27)31(44)42(33(41)47)21-6-2-18(3-7-21)14-26(32(45)46)39-30(43)28-24(34)15-20(16-25(28)35)40-50(48,49)22-8-4-19(5-9-22)29-37-12-13-38-29/h2-13,15-17,26,40H,14H2,1H3,(H,37,38)(H,39,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260674
PNG
(US9533985, 62)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H25F2N7O7S/c1-40-28-18-36-13-11-24(28)31(44)42(33(40)47)22-5-3-19(4-6-22)15-27(32(45)46)38-30(43)29-25(34)16-20(17-26(29)35)39-50(48,49)23-9-7-21(8-10-23)41-14-2-12-37-41/h2-14,16-18,27,39H,15H2,1H3,(H,38,43)(H,45,46)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260680
PNG
(US9533985, 68)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccnc(F)c4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H25F3N6O7S/c1-43-29-18-39-12-11-25(29)33(46)44(35(43)49)23-6-2-19(3-7-23)14-28(34(47)48)41-32(45)31-26(36)16-22(17-27(31)37)42-52(50,51)24-8-4-20(5-9-24)21-10-13-40-30(38)15-21/h2-13,15-18,28,42H,14H2,1H3,(H,41,45)(H,47,48)/t28-/m0/s1
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The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260653
PNG
(US9533985, 41)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N7O7S/c1-42-28-18-37-14-11-24(28)32(45)43(34(42)48)22-7-3-19(4-8-22)15-27(33(46)47)40-31(44)29-25(35)16-21(17-26(29)36)41-51(49,50)23-9-5-20(6-10-23)30-38-12-2-13-39-30/h2-14,16-18,27,41H,15H2,1H3,(H,40,44)(H,46,47)/t27-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260651
PNG
(US9533985, 39)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23FN6O7S/c1-35-25-16-32-13-10-22(25)27(38)36(29(35)41)19-5-2-17(3-6-19)14-24(28(39)40)33-26(37)21-7-4-18(15-23(21)30)34-44(42,43)20-8-11-31-12-9-20/h2-13,15-16,24,34H,14H2,1H3,(H,33,37)(H,39,40)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260673
PNG
(US9533985, 61)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4nccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C32H24F2N8O7S/c1-40-27-17-35-11-10-23(27)30(44)41(32(40)47)20-4-2-18(3-5-20)14-26(31(45)46)38-29(43)28-24(33)15-19(16-25(28)34)39-50(48,49)22-8-6-21(7-9-22)42-36-12-13-37-42/h2-13,15-17,26,39H,14H2,1H3,(H,38,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260689
PNG
(US9533985, 77)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-c5ncccn5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C33H26F2N8O7S/c1-41-17-38-29-27(41)31(45)43(33(48)42(29)2)21-8-4-18(5-9-21)14-25(32(46)47)39-30(44)26-23(34)15-20(16-24(26)35)40-51(49,50)22-10-6-19(7-11-22)28-36-12-3-13-37-28/h3-13,15-17,25,40H,14H2,1-2H3,(H,39,44)(H,46,47)/t25-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260656
PNG
(US9533985, 44)
Show SMILES CCNC(=O)c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)ccn(C)c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C30H27F2N5O8S/c1-3-33-27(39)18-6-10-21(11-7-18)46(44,45)35-19-15-22(31)26(23(32)16-19)28(40)34-24(29(41)42)14-17-4-8-20(9-5-17)37-25(38)12-13-36(2)30(37)43/h4-13,15-16,24,35H,3,14H2,1-2H3,(H,33,39)(H,34,40)(H,41,42)/t24-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260668
PNG
(US9533985, 56)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4cncn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-9-8-24(39)38(28(36)43)18-4-2-16(3-5-18)10-22(27(41)42)34-26(40)25-20(29)11-17(12-21(25)30)35-46(44,45)23-7-6-19(13-32-23)37-15-31-14-33-37/h2-9,11-15,22,35H,10H2,1H3,(H,34,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260662
PNG
(US9533985, 50)
Show SMILES Cc1ccc(cn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-3-6-23(18-40-20)22-7-11-26(12-8-22)52(50,51)42-24-16-28(37)32(29(38)17-24)33(45)41-30(35(47)48)15-21-4-9-25(10-5-21)44-34(46)27-13-14-39-19-31(27)43(2)36(44)49/h3-14,16-19,30,42H,15H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260658
PNG
(US9533985, 46)
Show SMILES COc1cc2c(cn1)n(C)c(=O)n(-c1ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ncccn4)cc3F)C(O)=O)cc1)c2=O
Show InChI InChI=1S/C35H27F2N7O8S/c1-43-28-18-40-29(52-2)17-24(28)33(46)44(35(43)49)22-8-4-19(5-9-22)14-27(34(47)48)41-32(45)30-25(36)15-21(16-26(30)37)42-53(50,51)23-10-6-20(7-11-23)31-38-12-3-13-39-31/h3-13,15-18,27,42H,14H2,1-2H3,(H,41,45)(H,47,48)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65449
PNG
(US9533985, 235)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-c4cc(F)cc(F)c4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C35H24F4N6O7S/c1-44-31-17-40-9-8-25(31)33(47)45(35(44)50)23-5-4-22(41-16-23)13-30(34(48)49)42-32(46)26-14-28(39)29(15-27(26)38)43-53(51,52)24-6-2-18(3-7-24)19-10-20(36)12-21(37)11-19/h2-12,14-17,30,43H,13H2,1H3,(H,42,46)(H,48,49)/t30-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65440
PNG
(US9533985, 230)
Show SMILES Cn1c2cccnc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cn4)-c4ncccn4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C32H23F2N9O7S/c1-42-25-4-2-9-35-27(25)30(45)43(32(42)48)19-7-6-18(38-16-19)12-24(31(46)47)40-29(44)20-13-22(34)23(14-21(20)33)41-51(49,50)26-8-5-17(15-39-26)28-36-10-3-11-37-28/h2-11,13-16,24,41H,12H2,1H3,(H,40,44)(H,46,47)/t24-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65436
PNG
(US9533985, 228)
Show SMILES COc1ncc(cn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(cn1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C34H26F2N8O8S/c1-43-29-17-37-10-9-23(29)31(46)44(34(43)49)21-6-5-20(38-16-21)11-28(32(47)48)41-30(45)24-12-26(36)27(13-25(24)35)42-53(50,51)22-7-3-18(4-8-22)19-14-39-33(52-2)40-15-19/h3-10,12-17,28,42H,11H2,1-2H3,(H,41,45)(H,47,48)/t28-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65424
PNG
(US9533985, 223)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)C(=O)C4CC4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C33H26F2N6O8S/c1-40-28-16-36-11-10-22(28)31(44)41(33(40)47)20-7-6-19(37-15-20)12-27(32(45)46)38-30(43)23-13-25(35)26(14-24(23)34)39-50(48,49)21-8-4-18(5-9-21)29(42)17-2-3-17/h4-11,13-17,27,39H,2-3,12H2,1H3,(H,38,43)(H,45,46)/t27-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65405
PNG
(US9533985, 144)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3ccc(NS(=O)(=O)c4ccc5CCC(=O)c5c4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C33H26FN5O8S/c1-38-28-17-35-13-12-24(28)31(42)39(33(38)45)21-7-2-18(3-8-21)14-27(32(43)44)36-30(41)23-10-6-20(15-26(23)34)37-48(46,47)22-9-4-19-5-11-29(40)25(19)16-22/h2-4,6-10,12-13,15-17,27,37H,5,11,14H2,1H3,(H,36,41)(H,43,44)/t27-/m0/s1
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Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65423
PNG
(US9533985, 222)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-c4ncccn4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C33H24F2N8O7S/c1-42-28-17-36-12-9-22(28)31(45)43(33(42)48)20-6-5-19(39-16-20)13-27(32(46)47)40-30(44)23-14-25(35)26(15-24(23)34)41-51(49,50)21-7-3-18(4-8-21)29-37-10-2-11-38-29/h2-12,14-17,27,41H,13H2,1H3,(H,40,44)(H,46,47)/t27-/m0/s1
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Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65444
PNG
(US9533985, 233)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc5COC(=O)c5c4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C31H22F2N6O9S/c1-38-26-13-34-7-6-19(26)28(41)39(31(38)45)17-4-3-16(35-12-17)8-25(29(42)43)36-27(40)21-10-23(33)24(11-22(21)32)37-49(46,47)18-5-2-15-14-48-30(44)20(15)9-18/h2-7,9-13,25,37H,8,14H2,1H3,(H,36,40)(H,42,43)/t25-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65443
PNG
(US9533985, 232)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccc(cc4)-c4cnc(nc4)N4CCC4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C36H29F2N9O7S/c1-45-31-19-39-10-9-25(31)33(49)47(36(45)52)23-6-5-22(40-18-23)13-30(34(50)51)43-32(48)26-14-28(38)29(15-27(26)37)44-55(53,54)24-7-3-20(4-8-24)21-16-41-35(42-17-21)46-11-2-12-46/h3-10,14-19,30,44H,2,11-13H2,1H3,(H,43,48)(H,50,51)/t30-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65439
PNG
(US9533985, 229)
Show SMILES CCc1ncc(cn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(cn1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C35H28F2N8O7S/c1-3-31-40-15-20(16-41-31)19-4-8-23(9-5-19)53(51,52)43-28-14-26(36)25(13-27(28)37)32(46)42-29(34(48)49)12-21-6-7-22(17-39-21)45-33(47)24-10-11-38-18-30(24)44(2)35(45)50/h4-11,13-18,29,43H,3,12H2,1-2H3,(H,42,46)(H,48,49)/t29-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65435
PNG
(US9533985, 227)
Show SMILES Cc1cc(cc(C)n1)-c1ccc(nc1)S(=O)(=O)Nc1cc(F)c(cc1F)C(=O)N[C@@H](Cc1ccc(cn1)-n1c(=O)n(C)c2cnccc2c1=O)C(O)=O
Show InChI InChI=1S/C35H28F2N8O7S/c1-18-10-21(11-19(2)41-18)20-4-7-31(40-15-20)53(51,52)43-28-14-26(36)25(13-27(28)37)32(46)42-29(34(48)49)12-22-5-6-23(16-39-22)45-33(47)24-8-9-38-17-30(24)44(3)35(45)50/h4-11,13-17,29,43H,12H2,1-3H3,(H,42,46)(H,48,49)/t29-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65418
PNG
(US9533985, 138)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccccn4)cc3F)C(O)=O)nc2)c1=O
Show InChI InChI=1S/C28H21F2N7O7S/c1-36-23-14-31-9-7-17(23)26(39)37(28(36)42)16-6-5-15(33-13-16)10-22(27(40)41)34-25(38)18-11-20(30)21(12-19(18)29)35-45(43,44)24-4-2-3-8-32-24/h2-9,11-14,22,35H,10H2,1H3,(H,34,38)(H,40,41)/t22-/m0/s1
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Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin


(Mus musculus (Mouse)-Homo sapiens (Human)-Homo sap...)
BDBM65411
PNG
(US9533985, 137)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3cc(F)c(NS(=O)(=O)c4ccccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N5O7S/c1-36-26-16-33-12-11-20(26)28(39)37(30(36)42)18-9-7-17(8-10-18)13-25(29(40)41)34-27(38)21-14-23(32)24(15-22(21)31)35-45(43,44)19-5-3-2-4-6-19/h2-12,14-16,25,35H,13H2,1H3,(H,34,38)(H,40,41)/t25-/m0/s1
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Assay Description
The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260679
PNG
(US9533985, 67)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccncc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C35H26F2N6O7S/c1-42-30-19-39-15-12-26(30)33(45)43(35(42)48)24-6-2-20(3-7-24)16-29(34(46)47)40-32(44)31-27(36)17-23(18-28(31)37)41-51(49,50)25-8-4-21(5-9-25)22-10-13-38-14-11-22/h2-15,17-19,29,41H,16H2,1H3,(H,40,44)(H,46,47)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM65394
PNG
(US9533985, 159 | US9533985, 40)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4ncccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-12-9-25(40)39(30(38)44)20-6-3-17(4-7-20)13-23(29(42)43)36-28(41)26-21(31)14-19(15-22(26)32)37-47(45,46)24-8-5-18(16-35-24)27-33-10-2-11-34-27/h2-12,14-16,23,37H,13H2,1H3,(H,36,41)(H,42,43)/t23-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260655
PNG
(US9533985, 43)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H26F2N6O7S/c1-40-29-19-37-13-12-25(29)32(44)42(34(40)47)23-6-4-20(5-7-23)16-28(33(45)46)38-31(43)30-26(35)17-21(18-27(30)36)39-50(48,49)24-10-8-22(9-11-24)41-14-2-3-15-41/h2-15,17-19,28,39H,16H2,1H3,(H,38,43)(H,45,46)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260682
PNG
(US9533985, 70)
Show SMILES Cc1cc(cc(C)n1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C37H30F2N6O7S/c1-20-14-24(15-21(2)41-20)23-6-10-27(11-7-23)53(51,52)43-25-17-29(38)33(30(39)18-25)34(46)42-31(36(48)49)16-22-4-8-26(9-5-22)45-35(47)28-12-13-40-19-32(28)44(3)37(45)50/h4-15,17-19,31,43H,16H2,1-3H3,(H,42,46)(H,48,49)/t31-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260678
PNG
(US9533985, 66)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccoc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O8S/c1-40-29-17-37-12-10-25(29)32(43)41(34(40)46)23-6-2-19(3-7-23)14-28(33(44)45)38-31(42)30-26(35)15-22(16-27(30)36)39-50(47,48)24-8-4-20(5-9-24)21-11-13-49-18-21/h2-13,15-18,28,39H,14H2,1H3,(H,38,42)(H,44,45)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260687
PNG
(US9533985, 75)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-c5ccncc5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C34H27F2N7O7S/c1-41-18-38-30-29(41)32(45)43(34(48)42(30)2)23-7-3-19(4-8-23)15-27(33(46)47)39-31(44)28-25(35)16-22(17-26(28)36)40-51(49,50)24-9-5-20(6-10-24)21-11-13-37-14-12-21/h3-14,16-18,27,40H,15H2,1-2H3,(H,39,44)(H,46,47)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260661
PNG
(US9533985, 49)
Show SMILES Cc1cc(ccn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-15-23(11-14-40-20)22-5-9-26(10-6-22)52(50,51)42-24-17-28(37)32(29(38)18-24)33(45)41-30(35(47)48)16-21-3-7-25(8-4-21)44-34(46)27-12-13-39-19-31(27)43(2)36(44)49/h3-15,17-19,30,42H,16H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260659
PNG
(US9533985, 47)
Show SMILES CN(C)c1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5cncn5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C35H30F2N8O7S/c1-42(2)24-10-13-30-26(17-24)33(47)45(35(50)43(30)3)23-6-4-20(5-7-23)14-29(34(48)49)40-32(46)31-27(36)15-21(16-28(31)37)41-53(51,52)25-11-8-22(9-12-25)44-19-38-18-39-44/h4-13,15-19,29,41H,14H2,1-3H3,(H,40,46)(H,48,49)/t29-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


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More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260690
PNG
(US9533985, 78)
Show SMILES COc1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)C(=O)NC5CC5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C36H31F2N5O9S/c1-42-30-14-11-24(52-2)18-26(30)34(46)43(36(42)49)23-9-3-19(4-10-23)15-29(35(47)48)40-33(45)31-27(37)16-22(17-28(31)38)41-53(50,51)25-12-5-20(6-13-25)32(44)39-21-7-8-21/h3-6,9-14,16-18,21,29,41H,7-8,15H2,1-2H3,(H,39,44)(H,40,45)(H,47,48)/t29-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260684
PNG
(US9533985, 72)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4nccn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-11-8-24(39)37(28(36)43)18-4-2-16(3-5-18)12-22(27(41)42)34-26(40)25-20(29)13-17(14-21(25)30)35-46(44,45)23-7-6-19(15-31-23)38-32-9-10-33-38/h2-11,13-15,22,35H,12H2,1H3,(H,34,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260685
PNG
(US9533985, 73)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C28H22F2N8O7S/c1-36-10-8-24(39)38(28(36)43)18-4-2-16(3-5-18)12-22(27(41)42)33-26(40)25-20(29)13-17(14-21(25)30)34-46(44,45)23-7-6-19(15-31-23)37-11-9-32-35-37/h2-11,13-15,22,34H,12H2,1H3,(H,33,40)(H,41,42)/t22-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260670
PNG
(US9533985, 58)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4ccnn4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C29H23F2N7O7S/c1-36-12-10-25(39)38(29(36)43)20-4-2-17(3-5-20)14-24(28(41)42)33-27(40)26-22(30)15-18(16-23(26)31)34-46(44,45)21-8-6-19(7-9-21)37-13-11-32-35-37/h2-13,15-16,24,34H,14H2,1H3,(H,33,40)(H,41,42)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260677
PNG
(US9533985, 65)
Show SMILES Cc1cnccc1-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C36H28F2N6O7S/c1-20-18-39-13-11-26(20)22-5-9-25(10-6-22)52(50,51)42-23-16-28(37)32(29(38)17-23)33(45)41-30(35(47)48)15-21-3-7-24(8-4-21)44-34(46)27-12-14-40-19-31(27)43(2)36(44)49/h3-14,16-19,30,42H,15H2,1-2H3,(H,41,45)(H,47,48)/t30-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260675
PNG
(US9533985, 63)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cn4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C30H23F2N7O7S/c1-38-9-8-26(40)39(30(38)44)21-5-2-17(3-6-21)10-24(29(42)43)36-28(41)27-22(31)11-20(12-23(27)32)37-47(45,46)25-7-4-18(15-35-25)19-13-33-16-34-14-19/h2-9,11-16,24,37H,10H2,1H3,(H,36,41)(H,42,43)/t24-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM65383
PNG
(BDBM260657 | US9533985, 157)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)C(=O)NC4CC4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H27F2N5O8S/c1-37-13-12-26(39)38(31(37)44)21-8-2-17(3-9-21)14-25(30(42)43)35-29(41)27-23(32)15-20(16-24(27)33)36-47(45,46)22-10-4-18(5-11-22)28(40)34-19-6-7-19/h2-5,8-13,15-16,19,25,36H,6-7,14H2,1H3,(H,34,40)(H,35,41)(H,42,43)/t25-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260686
PNG
(US9533985, 74)
Show SMILES Cc1cc(ccn1)-c1ccc(cc1)S(=O)(=O)Nc1cc(F)c(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3ncn(C)c3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C35H29F2N7O7S/c1-19-14-22(12-13-38-19)21-6-10-25(11-7-21)52(50,51)41-23-16-26(36)29(27(37)17-23)32(45)40-28(34(47)48)15-20-4-8-24(9-5-20)44-33(46)30-31(39-18-42(30)2)43(3)35(44)49/h4-14,16-18,28,41H,15H2,1-3H3,(H,40,45)(H,47,48)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM65398
PNG
(BDBM260664 | US9533985, 177)
Show SMILES CNCc1ccc(cc1)S(=O)(=O)Nc1ccc(C(=O)N[C@@H](Cc2ccc(cc2)-n2c(=O)n(C)c3cnccc3c2=O)C(O)=O)c(F)c1
Show InChI InChI=1S/C32H29FN6O7S/c1-34-17-20-5-10-23(11-6-20)47(45,46)37-21-7-12-24(26(33)16-21)29(40)36-27(31(42)43)15-19-3-8-22(9-4-19)39-30(41)25-13-14-35-18-28(25)38(2)32(39)44/h3-14,16,18,27,34,37H,15,17H2,1-2H3,(H,36,40)(H,42,43)/t27-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM65399
PNG
(US9533985, 178 | US9533985, 53)
Show SMILES Cn1c2cnccc2c(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4ccsc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C34H25F2N5O7S2/c1-40-29-17-37-12-10-25(29)32(43)41(34(40)46)23-6-2-19(3-7-23)14-28(33(44)45)38-31(42)30-26(35)15-22(16-27(30)36)39-50(47,48)24-8-4-20(5-9-24)21-11-13-49-18-21/h2-13,15-18,28,39H,14H2,1H3,(H,38,42)(H,44,45)/t28-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260688
PNG
(US9533985, 76)
Show SMILES Cn1cnc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5cccc5)cc4F)C(O)=O)cc3)c(=O)c12
Show InChI InChI=1S/C33H27F2N7O7S/c1-39-18-36-29-28(39)31(44)42(33(47)40(29)2)22-7-5-19(6-8-22)15-26(32(45)46)37-30(43)27-24(34)16-20(17-25(27)35)38-50(48,49)23-11-9-21(10-12-23)41-13-3-4-14-41/h3-14,16-18,26,38H,15H2,1-2H3,(H,37,43)(H,45,46)/t26-/m0/s1
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EA Pharma Co., Ltd.

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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260672
PNG
(US9533985, 60)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-c4cncnc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H24F2N6O7S/c1-38-11-10-27(40)39(31(38)44)22-6-2-18(3-7-22)12-26(30(42)43)36-29(41)28-24(32)13-21(14-25(28)33)37-47(45,46)23-8-4-19(5-9-23)20-15-34-17-35-16-20/h2-11,13-17,26,37H,12H2,1H3,(H,36,41)(H,42,43)/t26-/m0/s1
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Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260676
PNG
(US9533985, 64)
Show SMILES Cn1ccc(=O)n(-c2ccc(C[C@H](NC(=O)c3c(F)cc(NS(=O)(=O)c4ccc(cc4)-n4cccc4)cc3F)C(O)=O)cc2)c1=O
Show InChI InChI=1S/C31H25F2N5O7S/c1-36-15-12-27(39)38(31(36)43)22-6-4-19(5-7-22)16-26(30(41)42)34-29(40)28-24(32)17-20(18-25(28)33)35-46(44,45)23-10-8-21(9-11-23)37-13-2-3-14-37/h2-15,17-18,26,35H,16H2,1H3,(H,34,40)(H,41,42)/t26-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin


(Homo sapiens (human)-Homo sapiens (Human))
BDBM260663
PNG
(US9533985, 51)
Show SMILES COc1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5ccnn5)cc4F)C(O)=O)cc3)c(=O)c2c1
Show InChI InChI=1S/C34H27F2N7O8S/c1-41-29-12-9-23(51-2)18-25(29)32(45)43(34(41)48)22-5-3-19(4-6-22)15-28(33(46)47)38-31(44)30-26(35)16-20(17-27(30)36)39-52(49,50)24-10-7-21(8-11-24)42-14-13-37-40-42/h3-14,16-18,28,39H,15H2,1-2H3,(H,38,44)(H,46,47)/t28-/m0/s1
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EA Pharma Co., Ltd.

US Patent


Assay Description
The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%