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Patent code US9533999

Compile Data Set for Download or QSAR
Found 64 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200905
PNG
(US9533999, i-39)
Show SMILES Fc1ccc(CN2c3sccc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-10(9)23-14(16,17)18)6-19-12(20)7-25(21,22)11-3-4-24-13(11)19/h1-5H,6-7H2
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n/an/a 39n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019905
PNG
(CHEMBL3287210 | US9533999, ii-4)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
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n/an/a 41n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200937
PNG
(US9533999, ii-5)
Show SMILES FC(F)(F)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2OS/c16-11-4-3-9(6-10(11)15(17,18)19)7-21-13(22)8-23-12-2-1-5-20-14(12)21/h1-6H,7-8H2
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n/an/a 46n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200946
PNG
(US9533999, ii-8)
Show SMILES FC(F)(F)S(=O)(=O)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2O3S2/c16-10-4-3-9(6-12(10)26(23,24)15(17,18)19)7-21-13(22)8-25-11-2-1-5-20-14(11)21/h1-6H,7-8H2
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n/an/a 47n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019903
PNG
(CHEMBL3287208 | US9533999, i-40)
Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2
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n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019900
PNG
(CHEMBL3287205 | US9533999, i-5)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
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n/an/a 49n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200942
PNG
(US9533999, ii-7)
Show SMILES FC(F)(F)Sc1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2OS2/c16-10-4-3-9(6-12(10)24-15(17,18)19)7-21-13(22)8-23-11-2-1-5-20-14(11)21/h1-6H,7-8H2
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n/an/a 52n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019904
PNG
(CHEMBL3287209 | US9533999, ii-1)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2
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n/an/a 52n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200966
PNG
(US9533999, ii-17)
Show SMILES Fc1ccc(CN2c3scnc3SCC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C13H8F4N2O2S2/c14-8-2-1-7(3-9(8)21-13(15,16)17)4-19-10(20)5-22-11-12(19)23-6-18-11/h1-3,6H,4-5H2
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n/an/a 60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019906
PNG
(CHEMBL3287211 | US9533999, ii-11)
Show SMILES OCc1ccc2SCC(=O)N(Cc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C16H12ClF3N2O2S/c17-12-3-1-9(5-11(12)16(18,19)20)6-22-14(24)8-25-13-4-2-10(7-23)21-15(13)22/h1-5,23H,6-8H2
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n/an/a 66n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200973
PNG
(US9533999, ii-23)
Show SMILES CC(N1c2nc(C)sc2SCC1=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2OS2/c1-8(10-4-3-5-11(6-10)15(16,17)18)20-12(21)7-22-14-13(20)19-9(2)23-14/h3-6,8H,7H2,1-2H3
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n/an/a 67n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200904
PNG
(US9533999, i-38)
Show SMILES CC(N1c2sccc2S(=O)(=O)CC1=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H12F3NO3S2/c1-9(10-3-2-4-11(7-10)15(16,17)18)19-13(20)8-24(21,22)12-5-6-23-14(12)19/h2-7,9H,8H2,1H3
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n/an/a 71n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200971
PNG
(US9533999, ii-22)
Show SMILES Cc1nc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CSc2s1
Show InChI InChI=1S/C14H11F3N2OS2/c1-8-18-12-13(22-8)21-7-11(20)19(12)6-9-3-2-4-10(5-9)14(15,16)17/h2-5H,6-7H2,1H3
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n/an/a 73n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200855
PNG
(US9533999, i-12)
Show SMILES FC(F)(F)Oc1cc(CN2C(=O)CS(=O)(=O)c3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
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n/an/a 77n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200862
PNG
(US9533999, i-18)
Show SMILES COC(=O)c1ccc2c(n1)N(Cc1ccc(F)c(OC(F)(F)F)c1)C(=O)CS2(=O)=O
Show InChI InChI=1S/C17H12F4N2O6S/c1-28-16(25)11-4-5-13-15(22-11)23(14(24)8-30(13,26)27)7-9-2-3-10(18)12(6-9)29-17(19,20)21/h2-6H,7-8H2,1H3
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n/an/a 88n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200858
PNG
(US9533999, i-15)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cc(Cl)cnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H9ClF4N2O4S/c16-9-4-12-14(21-5-9)22(13(23)7-27(12,24)25)6-8-1-2-10(17)11(3-8)26-15(18,19)20/h1-5H,6-7H2
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n/an/a 92n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019901
PNG
(CHEMBL3287206 | US9533999, i-34)
Show SMILES CC(C)c1nc2N(Cc3ccc(F)c(OC(F)(F)F)c3)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C16H14F4N2O4S2/c1-8(2)14-21-13-15(27-14)28(24,25)7-12(23)22(13)6-9-3-4-10(17)11(5-9)26-16(18,19)20/h3-5,8H,6-7H2,1-2H3
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n/an/a 96n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200852
PNG
(US9533999, i-9)
Show SMILES CC(N1C(=O)CS(=O)(=O)c2cc(Cl)cnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12ClF3N2O3S/c1-9(10-3-2-4-11(5-10)16(18,19)20)22-14(23)8-26(24,25)13-6-12(17)7-21-15(13)22/h2-7,9H,8H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200894
PNG
(US9533999, i-33)
Show SMILES Fc1ccc(CN2c3ncsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C13H8F4N2O4S2/c14-8-2-1-7(3-9(8)23-13(15,16)17)4-19-10(20)5-25(21,22)12-11(19)18-6-24-12/h1-3,6H,4-5H2
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n/an/a 110n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200840
PNG
(US9533999, i-2)
Show SMILES CC(N1C(=O)CS(=O)(=O)c2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2O3S/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-25(23,24)13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200930
PNG
(US9533999, i-43)
Show SMILES COC(=O)c1cc2N(C(C)c3cccc(c3)C(F)(F)F)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C17H14F3NO5S2/c1-9(10-4-3-5-11(6-10)17(18,19)20)21-12-7-13(15(23)26-2)27-16(12)28(24,25)8-14(21)22/h3-7,9H,8H2,1-2H3
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n/an/a 120n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200947
PNG
(US9533999, ii-9)
Show SMILES Fc1ccc(CN2C(=O)CSc3cc(Cl)cnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H9ClF4N2O2S/c16-9-4-12-14(21-5-9)22(13(23)7-25-12)6-8-1-2-10(17)11(3-8)24-15(18,19)20/h1-5H,6-7H2
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n/an/a 130n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200842
PNG
(US9533999, i-4)
Show SMILES CC(N1C(=O)CS(=O)(=O)c2cccnc12)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C16H12ClF3N2O3S/c1-9(10-4-5-12(17)11(7-10)16(18,19)20)22-14(23)8-26(24,25)13-3-2-6-21-15(13)22/h2-7,9H,8H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200929
PNG
(US9533999, i-42)
Show SMILES COC(=O)c1cc2N(Cc3cccc(OC(F)(F)F)c3)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C16H12F3NO6S2/c1-25-14(22)12-6-11-15(27-12)28(23,24)8-13(21)20(11)7-9-3-2-4-10(5-9)26-16(17,18)19/h2-6H,7-8H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200955
PNG
(US9533999, ii-13)
Show SMILES FC(F)(F)Oc1cccc(CN2c3scnc3SCC2=O)c1
Show InChI InChI=1S/C13H9F3N2O2S2/c14-13(15,16)20-9-3-1-2-8(4-9)5-18-10(19)6-21-11-12(18)22-7-17-11/h1-4,7H,5-6H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200870
PNG
(US9533999, i-23)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3nccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4N3O4S/c15-9-2-1-8(5-10(9)25-14(16,17)18)6-21-11(22)7-26(23,24)13-12(21)19-3-4-20-13/h1-5H,6-7H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200965
PNG
(US9533999, ii-16)
Show SMILES CC(N1c2scnc2SCC1=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2OS2/c1-8(9-3-2-4-10(5-9)14(15,16)17)19-11(20)6-21-12-13(19)22-7-18-12/h2-5,7-8H,6H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200935
PNG
(US9533999, ii-3)
Show SMILES NC(=O)c1ccc2SCC(=O)N(Cc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C16H11ClF3N3O2S/c17-10-2-1-8(5-9(10)16(18,19)20)6-23-13(24)7-26-12-4-3-11(14(21)25)22-15(12)23/h1-5H,6-7H2,(H2,21,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200841
PNG
(US9533999, i-3)
Show SMILES FC(F)(F)c1cc(CN2C(=O)CS(=O)(=O)c3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2O3S/c16-11-4-3-9(6-10(11)15(17,18)19)7-21-13(22)8-25(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200853
PNG
(US9533999, i-10)
Show SMILES FC(F)(F)c1cc(CN2C(=O)CS(=O)(=O)c3cc(Cl)cnc23)ccc1Cl
Show InChI InChI=1S/C15H9Cl2F3N2O3S/c16-9-4-12-14(21-5-9)22(13(23)7-26(12,24)25)6-8-1-2-11(17)10(3-8)15(18,19)20/h1-5H,6-7H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200923
PNG
(US9533999, i-41)
Show SMILES COC(=O)c1cc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C16H12F3NO5S2/c1-25-14(22)12-6-11-15(26-12)27(23,24)8-13(21)20(11)7-9-3-2-4-10(5-9)16(17,18)19/h2-6H,7-8H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200900
PNG
(US9533999, i-37)
Show SMILES Cc1nc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C14H11F3N2O3S2/c1-8-18-12-13(23-8)24(21,22)7-11(20)19(12)6-9-3-2-4-10(5-9)14(15,16)17/h2-5H,6-7H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200865
PNG
(US9533999, i-21)
Show SMILES CC(N1C(=O)CS(=O)(=O)c2ncc(Br)cc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12BrF3N2O3S/c1-9(10-3-2-4-11(5-10)16(18,19)20)22-13-6-12(17)7-21-15(13)26(24,25)8-14(22)23/h2-7,9H,8H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200896
PNG
(US9533999, i-35)
Show SMILES CC(C)c1nc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C16H15F3N2O3S2/c1-9(2)14-20-13-15(25-14)26(23,24)8-12(22)21(13)7-10-4-3-5-11(6-10)16(17,18)19/h3-6,9H,7-8H2,1-2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200967
PNG
(US9533999, ii-18)
Show SMILES CC(C)c1nc2N(Cc3ccc(F)c(OC(F)(F)F)c3)C(=O)CSc2s1
Show InChI InChI=1S/C16H14F4N2O2S2/c1-8(2)14-21-13-15(26-14)25-7-12(23)22(13)6-9-3-4-10(17)11(5-9)24-16(18,19)20/h3-5,8H,6-7H2,1-2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200952
PNG
(US9533999, ii-12)
Show SMILES Cc1nc2SCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c2s1
Show InChI InChI=1S/C14H11F3N2O2S2/c1-8-18-12-13(23-8)19(11(20)7-22-12)6-9-3-2-4-10(5-9)21-14(15,16)17/h2-5H,6-7H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200839
PNG
(US9533999, i-1)
Show SMILES FC(F)(F)c1cccc(CN2C(=O)CS(=O)(=O)c3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O3S/c16-15(17,18)11-4-1-3-10(7-11)8-20-13(21)9-24(22,23)12-5-2-6-19-14(12)20/h1-7H,8-9H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200948
PNG
(US9533999, ii-10)
Show SMILES Brc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C14H11BrN2OS/c15-11-4-1-3-10(7-11)8-17-13(18)9-19-12-5-2-6-16-14(12)17/h1-7H,8-9H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200879
PNG
(US9533999, i-27)
Show SMILES Cc1nc2c(s1)N(Cc1ccc(F)c(OC(F)(F)F)c1)C(=O)CS2(=O)=O
Show InChI InChI=1S/C14H10F4N2O4S2/c1-7-19-12-13(25-7)20(11(21)6-26(12,22)23)5-8-2-3-9(15)10(4-8)24-14(16,17)18/h2-4H,5-6H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200933
PNG
(US9533999, ii-2)
Show SMILES FC(F)(F)c1cccc(CN2c3scnc3SCC2=O)c1
Show InChI InChI=1S/C13H9F3N2OS2/c14-13(15,16)9-3-1-2-8(4-9)5-18-10(19)6-20-11-12(18)21-7-17-11/h1-4,7H,5-6H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200968
PNG
(US9533999, ii-19)
Show SMILES CC(C)c1nc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CSc2s1
Show InChI InChI=1S/C16H15F3N2OS2/c1-9(2)14-20-13-15(24-14)23-8-12(22)21(13)7-10-4-3-5-11(6-10)16(17,18)19/h3-6,9H,7-8H2,1-2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200846
PNG
(US9533999, i-7)
Show SMILES FC(F)(F)c1cccc(CCN2C(=O)CS(=O)(=O)c3cccnc23)c1
Show InChI InChI=1S/C16H13F3N2O3S/c17-16(18,19)12-4-1-3-11(9-12)6-8-21-14(22)10-25(23,24)13-5-2-7-20-15(13)21/h1-5,7,9H,6,8,10H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200861
PNG
(US9533999, i-17)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CS(=O)(=O)c3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O4S/c16-15(17,18)24-11-4-1-3-10(7-11)8-20-13(21)9-25(22,23)12-5-2-6-19-14(12)20/h1-7H,8-9H2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200899
PNG
(US9533999, i-36)
Show SMILES CC(C)c1nc2N(Cc3cccc(OC(F)(F)F)c3)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C16H15F3N2O4S2/c1-9(2)14-20-13-15(26-14)27(23,24)8-12(22)21(13)7-10-4-3-5-11(6-10)25-16(17,18)19/h3-6,9H,7-8H2,1-2H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200970
PNG
(US9533999, ii-21)
Show SMILES CC(C)c1nc2N(C(C)c3cccc(c3)C(F)(F)F)C(=O)CSc2s1
Show InChI InChI=1S/C17H17F3N2OS2/c1-9(2)15-21-14-16(25-15)24-8-13(23)22(14)10(3)11-5-4-6-12(7-11)17(18,19)20/h4-7,9-10H,8H2,1-3H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200964
PNG
(US9533999, ii-15)
Show SMILES Cc1nc2SCC(=O)N(Cc3cccc(c3)C(F)(F)F)c2s1
Show InChI InChI=1S/C14H11F3N2OS2/c1-8-18-12-13(22-8)19(11(20)7-21-12)6-9-3-2-4-10(5-9)14(15,16)17/h2-5H,6-7H2,1H3
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200864
PNG
(US9533999, i-20)
Show SMILES NC(=O)c1ccc2c(n1)N(Cc1ccc(Cl)c(c1)C(F)(F)F)C(=O)CS2(=O)=O
Show InChI InChI=1S/C16H11ClF3N3O4S/c17-10-2-1-8(5-9(10)16(18,19)20)6-23-13(24)7-28(26,27)12-4-3-11(14(21)25)22-15(12)23/h1-5H,6-7H2,(H2,21,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200874
PNG
(US9533999, i-26)
Show SMILES Fc1ccc(CN2c3scnc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C13H8F4N2O4S2/c14-8-2-1-7(3-9(8)23-13(15,16)17)4-19-10(20)5-25(21,22)11-12(19)24-6-18-11/h1-3,6H,4-5H2
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n/an/a 510n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200969
PNG
(US9533999, ii-20)
Show SMILES CC(C)c1nc2N(Cc3cccc(OC(F)(F)F)c3)C(=O)CSc2s1
Show InChI InChI=1S/C16H15F3N2O2S2/c1-9(2)14-20-13-15(25-14)24-8-12(22)21(13)7-10-4-3-5-11(6-10)23-16(17,18)19/h3-6,9H,7-8H2,1-2H3
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n/an/a 510n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200856
PNG
(US9533999, i-13)
Show SMILES FC(F)(F)S(=O)(=O)c1cc(CN2C(=O)CS(=O)(=O)c3cccnc23)ccc1Cl
Show InChI InChI=1S/C15H10ClF3N2O5S2/c16-10-4-3-9(6-12(10)28(25,26)15(17,18)19)7-21-13(22)8-27(23,24)11-2-1-5-20-14(11)21/h1-6H,7-8H2
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n/an/a 830n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200893
PNG
(US9533999, i-32)
Show SMILES CC(N1c2scnc2S(=O)(=O)CC1=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O3S2/c1-8(9-3-2-4-10(5-9)14(15,16)17)19-11(20)6-24(21,22)12-13(19)23-7-18-12/h2-5,7-8H,6H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200869
PNG
(US9533999, i-22)
Show SMILES C[C@H](N1C(=O)CS(=O)(=O)c2nccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H12F3N3O3S/c1-9(10-3-2-4-11(7-10)15(16,17)18)21-12(22)8-25(23,24)14-13(21)19-5-6-20-14/h2-7,9H,8H2,1H3/t9-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200963
PNG
(US9533999, ii-14)
Show SMILES FC(F)(F)c1cccc(CN2c3sc(nc3SCC2=O)C2CC2)c1
Show InChI InChI=1S/C16H13F3N2OS2/c17-16(18,19)11-3-1-2-9(6-11)7-21-12(22)8-23-14-15(21)24-13(20-14)10-4-5-10/h1-3,6,10H,4-5,7-8H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200847
PNG
(US9533999, i-8)
Show SMILES CC(N1C(=O)CS(=O)(=O)c2cccnc12)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C15H12F3N3O3S/c1-9(11-7-10(4-6-19-11)15(16,17)18)21-13(22)8-25(23,24)12-3-2-5-20-14(12)21/h2-7,9H,8H2,1H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200859
PNG
(US9533999, i-16)
Show SMILES Clc1cccc(CCN2C(=O)CS(=O)(=O)c3cccnc23)c1
Show InChI InChI=1S/C15H13ClN2O3S/c16-12-4-1-3-11(9-12)6-8-18-14(19)10-22(20,21)13-5-2-7-17-15(13)18/h1-5,7,9H,6,8,10H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200892
PNG
(US9533999, i-31)
Show SMILES FC(F)(F)Oc1cccc(CN2c3scnc3S(=O)(=O)CC2=O)c1
Show InChI InChI=1S/C13H9F3N2O4S2/c14-13(15,16)22-9-3-1-2-8(4-9)5-18-10(19)6-24(20,21)11-12(18)23-7-17-11/h1-4,7H,5-6H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200863
PNG
(US9533999, i-19)
Show SMILES CC(N1C(=O)CS(=O)(=O)c2ccc(nc12)C(=O)N(C)C)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O4S/c1-11(12-5-4-6-13(9-12)19(20,21)22)25-16(26)10-30(28,29)15-8-7-14(23-17(15)25)18(27)24(2)3/h4-9,11H,10H2,1-3H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200889
PNG
(US9533999, i-29)
Show SMILES Cc1nc2c(s1)N(Cc1cccc(OC(F)(F)F)c1)C(=O)CS2(=O)=O
Show InChI InChI=1S/C14H11F3N2O4S2/c1-8-18-12-13(24-8)19(11(20)7-25(12,21)22)6-9-3-2-4-10(5-9)23-14(15,16)17/h2-5H,6-7H2,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200871
PNG
(US9533999, i-24)
Show SMILES FC(F)(F)c1cccc(CN2C(=O)CS(=O)(=O)c3nccnc23)c1
Show InChI InChI=1S/C14H10F3N3O3S/c15-14(16,17)10-3-1-2-9(6-10)7-20-11(21)8-24(22,23)13-12(20)18-4-5-19-13/h1-6H,7-8H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200938
PNG
(US9533999, ii-6)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cc(nn1C)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4OS/c1-8(9-6-11(14(15,16)17)19-20(9)2)21-12(22)7-23-10-4-3-5-18-13(10)21/h3-6,8H,7H2,1-2H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200873
PNG
(US9533999, i-25)
Show SMILES FC(F)(F)c1cccc(CN2c3scnc3S(=O)(=O)CC2=O)c1
Show InChI InChI=1S/C13H9F3N2O3S2/c14-13(15,16)9-3-1-2-8(4-9)5-18-10(19)6-23(20,21)11-12(18)22-7-17-11/h1-4,7H,5-6H2
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n/an/a 3.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200880
PNG
(US9533999, i-28)
Show SMILES Cc1nc2c(s1)N(Cc1cccc(c1)C(F)(F)F)C(=O)CS2(=O)=O
Show InChI InChI=1S/C14H11F3N2O3S2/c1-8-18-12-13(23-8)19(11(20)7-24(12,21)22)6-9-3-2-4-10(5-9)14(15,16)17/h2-5H,6-7H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200890
PNG
(US9533999, i-30)
Show SMILES FC(F)(F)c1cccc(CN2c3sc(nc3S(=O)(=O)CC2=O)C2CC2)c1
Show InChI InChI=1S/C16H13F3N2O3S2/c17-16(18,19)11-3-1-2-9(6-11)7-21-12(22)8-26(23,24)14-15(21)25-13(20-14)10-4-5-10/h1-3,6,10H,4-5,7-8H2
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n/an/a 4.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM200845
PNG
(US9533999, i-6)
Show SMILES FC(F)(F)c1ccccc1CCN1C(=O)CS(=O)(=O)c2cccnc12
Show InChI InChI=1S/C16H13F3N2O3S/c17-16(18,19)12-5-2-1-4-11(12)7-9-21-14(22)10-25(23,24)13-6-3-8-20-15(13)21/h1-6,8H,7,9-10H2
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n/an/a 5.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%