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Patent code US9539260

Compile Data Set for Download or QSAR

Found 567 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203372
PNG
(US9539260, B31)
Show SMILES Cc1cc(cnc1S(C)(=O)=O)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOC3)cc12
Show InChI InChI=1S/C24H29N3O6S/c1-16-11-18(13-25-23(16)34(2,29)30)27-8-10-32-22-4-3-19(12-21(22)27)33-20-5-7-26(14-20)24(28)17-6-9-31-15-17/h3-4,11-13,17,20H,5-10,14-15H2,1-2H3/t17?,20-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204089
PNG
(US9539260, F6)
Show SMILES Cc1cc(cnc1S(C)(=O)=O)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C24H30N4O6S/c1-16-11-18(13-26-23(16)35(2,30)31)28-7-10-33-21-14-25-22(12-20(21)28)34-19-3-6-27(15-19)24(29)17-4-8-32-9-5-17/h11-14,17,19H,3-10,15H2,1-2H3/t19-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203381
PNG
(US9539260, B38)
Show SMILES COc1cc(cnc1OC)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C25H31N3O6/c1-30-23-13-18(15-26-24(23)31-2)28-9-12-33-22-4-3-19(14-21(22)28)34-20-5-8-27(16-20)25(29)17-6-10-32-11-7-17/h3-4,13-15,17,20H,5-12,16H2,1-2H3/t20-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204008
PNG
(US9539260, D12)
Show SMILES COCC(=O)N1CC[C@@H](C1)Oc1ccc2OCCN(c3cnc(OC)c(c3)C#N)c2c1
Show InChI InChI=1S/C22H24N4O5/c1-28-14-21(27)25-6-5-18(13-25)31-17-3-4-20-19(10-17)26(7-8-30-20)16-9-15(11-23)22(29-2)24-12-16/h3-4,9-10,12,18H,5-8,13-14H2,1-2H3/t18-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204083
PNG
(US9539260, E11)
Show SMILES Cc1cc(cnc1OC(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CC3)cc12
Show InChI InChI=1S/C22H24F2N4O4/c1-13-8-15(10-26-20(13)32-22(23)24)28-6-7-30-18-11-25-19(9-17(18)28)31-16-4-5-27(12-16)21(29)14-2-3-14/h8-11,14,16,22H,2-7,12H2,1H3/t16-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203396
PNG
(US9539260, B52 | US9539260, B53)
Show SMILES Cc1cc(cnc1S(C)(=O)=O)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOC3)cc12
Show InChI InChI=1S/C24H29N3O6S/c1-16-11-18(13-25-23(16)34(2,29)30)27-8-10-32-22-4-3-19(12-21(22)27)33-20-5-7-26(14-20)24(28)17-6-9-31-15-17/h3-4,11-13,17,20H,5-10,14-15H2,1-2H3/t17?,20-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203414
PNG
(US9539260, B70)
Show SMILES CS(=O)(=O)c1ncc(cc1C(F)F)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C25H29F2N3O6S/c1-37(32,33)24-20(23(26)27)12-17(14-28-24)30-8-11-35-22-3-2-18(13-21(22)30)36-19-4-7-29(15-19)25(31)16-5-9-34-10-6-16/h2-3,12-14,16,19,23H,4-11,15H2,1H3/t19-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203425
PNG
(US9539260, B79)
Show SMILES CS(=O)(=O)c1ncc(cc1Cl)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C24H28ClN3O6S/c1-35(30,31)23-20(25)12-17(14-26-23)28-8-11-33-22-3-2-18(13-21(22)28)34-19-4-7-27(15-19)24(29)16-5-9-32-10-6-16/h2-3,12-14,16,19H,4-11,15H2,1H3/t19-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204062
PNG
(US9539260, D28 | US9539260, D29)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOC3)cc12
Show InChI InChI=1S/C24H26N4O5/c1-30-23-17(12-25)10-18(13-26-23)28-7-9-32-22-3-2-19(11-21(22)28)33-20-4-6-27(14-20)24(29)16-5-8-31-15-16/h2-3,10-11,13,16,20H,4-9,14-15H2,1H3/t16?,20-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204084
PNG
(US9539260, F1)
Show SMILES COc1ncc(cc1C)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CCS(=O)(=O)CC3)cc12
Show InChI InChI=1S/C24H30N4O6S/c1-16-11-18(13-26-23(16)32-2)28-7-8-33-21-14-25-22(12-20(21)28)34-19-3-6-27(15-19)24(29)17-4-9-35(30,31)10-5-17/h11-14,17,19H,3-10,15H2,1-2H3/t19-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204120
PNG
(US9539260, K)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)[C@@H]3CCN(C3)C(C)=O)cc12
Show InChI InChI=1S/C26H29N5O5/c1-17(32)29-7-5-18(15-29)26(33)30-8-6-22(16-30)36-21-3-4-24-23(12-21)31(9-10-35-24)20-11-19(13-27)25(34-2)28-14-20/h3-4,11-12,14,18,22H,5-10,15-16H2,1-2H3/t18-,22+/m1/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203662
PNG
(US9539260, B109)
Show SMILES COc1ncc(cc1Cl)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)CC#N)cc12
Show InChI InChI=1S/C21H21ClN4O4/c1-28-21-17(22)10-14(12-24-21)26-8-9-29-19-3-2-15(11-18(19)26)30-16-5-7-25(13-16)20(27)4-6-23/h2-3,10-12,16H,4-5,7-9,13H2,1H3/t16-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203663
PNG
(US9539260, B110)
Show SMILES COc1ncc(cc1Cl)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)CS(C)(=O)=O)cc12
Show InChI InChI=1S/C21H24ClN3O6S/c1-29-21-17(22)9-14(11-23-21)25-7-8-30-19-4-3-15(10-18(19)25)31-16-5-6-24(12-16)20(26)13-32(2,27)28/h3-4,9-11,16H,5-8,12-13H2,1-2H3/t16-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203908
PNG
(US9539260, C24 | US9539260, C25)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3COCCO3)cc12
Show InChI InChI=1S/C24H26N4O6/c1-30-23-16(12-25)10-17(13-26-23)28-6-7-32-21-3-2-18(11-20(21)28)34-19-4-5-27(14-19)24(29)22-15-31-8-9-33-22/h2-3,10-11,13,19,22H,4-9,14-15H2,1H3/t19-,22?/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204070
PNG
(US9539260, D35 | US9539260, D36)
Show SMILES COC1CCC(CC1)C(=O)N1CC[C@@H](C1)Oc1ccc2OCCN(c3cnc(OC)c(c3)C#N)c2c1
Show InChI InChI=1S/C27H32N4O5/c1-33-21-5-3-18(4-6-21)27(32)30-10-9-23(17-30)36-22-7-8-25-24(14-22)31(11-12-35-25)20-13-19(15-28)26(34-2)29-16-20/h7-8,13-14,16,18,21,23H,3-6,9-12,17H2,1-2H3/t18?,21?,23-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204087
PNG
(US9539260, F4)
Show SMILES COc1ncc(cc1C#N)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C24H27N5O5/c1-31-23-17(12-25)10-18(13-27-23)29-6-9-33-21-14-26-22(11-20(21)29)34-19-2-5-28(15-19)24(30)16-3-7-32-8-4-16/h10-11,13-14,16,19H,2-9,15H2,1H3/t19-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204092
PNG
(US9539260, F9)
Show SMILES COCC(=O)N1CC[C@@H](C1)Oc1cc2N(CCOc2cn1)c1cnc(OC)c(c1)C(F)F
Show InChI InChI=1S/C21H24F2N4O5/c1-29-12-19(28)26-4-3-14(11-26)32-18-8-16-17(10-24-18)31-6-5-27(16)13-7-15(20(22)23)21(30-2)25-9-13/h7-10,14,20H,3-6,11-12H2,1-2H3/t14-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM202490
PNG
(US9539260, A3)
Show SMILES O=C(C1CCOCC1)N1CC[C@@H](C1)Oc1ccc2OCCN(c3cncc(c3)S(=O)(=O)N3CCOCC3)c2c1
Show InChI InChI=1S/C27H34N4O7S/c32-27(20-4-10-35-11-5-20)29-6-3-23(19-29)38-22-1-2-26-25(16-22)31(9-14-37-26)21-15-24(18-28-17-21)39(33,34)30-7-12-36-13-8-30/h1-2,15-18,20,23H,3-14,19H2/t23-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203379
PNG
(US9539260, B36)
Show SMILES Cc1cc(cnc1S(C)(=O)=O)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3COCCO3)cc12
Show InChI InChI=1S/C24H29N3O7S/c1-16-11-17(13-25-23(16)35(2,29)30)27-7-8-32-21-4-3-18(12-20(21)27)34-19-5-6-26(14-19)24(28)22-15-31-9-10-33-22/h3-4,11-13,19,22H,5-10,14-15H2,1-2H3/t19-,22?/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203661
PNG
(US9539260, B108)
Show SMILES COc1ncc(cc1Cl)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)c3cnco3)cc12
Show InChI InChI=1S/C22H21ClN4O5/c1-29-21-17(23)8-14(10-25-21)27-6-7-30-19-3-2-15(9-18(19)27)32-16-4-5-26(12-16)22(28)20-11-24-13-31-20/h2-3,8-11,13,16H,4-7,12H2,1H3/t16-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204077
PNG
(US9539260, E3)
Show SMILES COc1ncc(cc1C)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C24H30N4O5/c1-16-11-18(13-26-23(16)30-2)28-7-10-32-21-14-25-22(12-20(21)28)33-19-3-6-27(15-19)24(29)17-4-8-31-9-5-17/h11-14,17,19H,3-10,15H2,1-2H3/t19-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204093
PNG
(US9539260, F10)
Show SMILES COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12
Show InChI InChI=1S/C23H24F2N6O4/c1-29-12-17(28-13-29)23(32)30-4-3-15(11-30)35-20-8-18-19(10-26-20)34-6-5-31(18)14-7-16(21(24)25)22(33-2)27-9-14/h7-10,12-13,15,21H,3-6,11H2,1-2H3/t15-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204090
PNG
(US9539260, F7)
Show SMILES COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CCS(=O)(=O)CC3)cc12
Show InChI InChI=1S/C24H28F2N4O6S/c1-34-23-18(22(25)26)10-16(12-28-23)30-6-7-35-20-13-27-21(11-19(20)30)36-17-2-5-29(14-17)24(31)15-3-8-37(32,33)9-4-15/h10-13,15,17,22H,2-9,14H2,1H3/t17-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM202513
PNG
(US9539260, A12)
Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ccc2OCCN(c3cnc(OC)c(Cl)c3)c2c1
Show InChI InChI=1S/C21H24ClN3O4/c1-3-20(26)24-7-6-16(13-24)29-15-4-5-19-18(11-15)25(8-9-28-19)14-10-17(22)21(27-2)23-12-14/h4-5,10-12,16H,3,6-9,13H2,1-2H3/t16-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204095
PNG
(US9539260, F12)
Show SMILES COc1ncc(cc1C)N1CCOc2cnc(OC3CCN(C3)C(=O)C3CCS(=O)(=O)CC3)cc12
Show InChI InChI=1S/C24H30N4O6S/c1-16-11-18(13-26-23(16)32-2)28-7-8-33-21-14-25-22(12-20(21)28)34-19-3-6-27(15-19)24(29)17-4-9-35(30,31)10-5-17/h11-14,17,19H,3-10,15H2,1-2H3
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203426
PNG
(US9539260, B80)
Show SMILES Cc1cc(cnc1S(C)(=O)=O)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CC3)cc12
Show InChI InChI=1S/C23H27N3O5S/c1-15-11-17(13-24-22(15)32(2,28)29)26-9-10-30-21-6-5-18(12-20(21)26)31-19-7-8-25(14-19)23(27)16-3-4-16/h5-6,11-13,16,19H,3-4,7-10,14H2,1-2H3/t19-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203464
PNG
(US9539260, B107)
Show SMILES COc1ncc(cc1Cl)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)CCO)cc12
Show InChI InChI=1S/C21H24ClN3O5/c1-28-21-17(22)10-14(12-23-21)25-7-9-29-19-3-2-15(11-18(19)25)30-16-4-6-24(13-16)20(27)5-8-26/h2-3,10-12,16,26H,4-9,13H2,1H3/t16-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203402
PNG
(US9539260, B58)
Show SMILES Cc1cc(cnc1Cl)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C24H28ClN3O4/c1-16-12-18(14-26-23(16)25)28-8-11-31-22-3-2-19(13-21(22)28)32-20-4-7-27(15-20)24(29)17-5-9-30-10-6-17/h2-3,12-14,17,20H,4-11,15H2,1H3/t20-/m0/s1
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NOVARTIS AG

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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203438
PNG
(US9539260, B93)
Show SMILES COc1ncc(cc1C)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCS(=O)(=O)CC3)cc12
Show InChI InChI=1S/C25H31N3O6S/c1-17-13-19(15-26-24(17)32-2)28-9-10-33-23-4-3-20(14-22(23)28)34-21-5-8-27(16-21)25(29)18-6-11-35(30,31)12-7-18/h3-4,13-15,18,21H,5-12,16H2,1-2H3/t21-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204076
PNG
(US9539260, E1)
Show SMILES COc1ncc(cc1C)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12
Show InChI InChI=1S/C23H26N6O4/c1-15-8-16(10-25-22(15)31-3)29-6-7-32-20-11-24-21(9-19(20)29)33-17-4-5-28(12-17)23(30)18-13-27(2)14-26-18/h8-11,13-14,17H,4-7,12H2,1-3H3/t17-/m0/s1
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NOVARTIS AG

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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203396
PNG
(US9539260, B52 | US9539260, B53)
Show SMILES Cc1cc(cnc1S(C)(=O)=O)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOC3)cc12
Show InChI InChI=1S/C24H29N3O6S/c1-16-11-18(13-25-23(16)34(2,29)30)27-8-10-32-22-4-3-19(12-21(22)27)33-20-5-7-26(14-20)24(28)17-6-9-31-15-17/h3-4,11-13,17,20H,5-10,14-15H2,1-2H3/t17?,20-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203371
PNG
(US9539260, B30 | US9539260, D1)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12
Show InChI InChI=1S/C24H24N6O4/c1-28-14-20(27-15-28)24(31)29-6-5-19(13-29)34-18-3-4-22-21(10-18)30(7-8-33-22)17-9-16(11-25)23(32-2)26-12-17/h3-4,9-10,12,14-15,19H,5-8,13H2,1-2H3/t19-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204009
PNG
(US9539260, D13)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCCCC3)cc12
Show InChI InChI=1S/C26H30N4O4/c1-32-25-19(15-27)13-20(16-28-25)30-11-12-33-24-8-7-21(14-23(24)30)34-22-9-10-29(17-22)26(31)18-5-3-2-4-6-18/h7-8,13-14,16,18,22H,2-6,9-12,17H2,1H3/t22-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204085
PNG
(US9539260, F2)
Show SMILES COc1ncc(cc1F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CCS(=O)(=O)CC3)cc12
Show InChI InChI=1S/C23H27FN4O6S/c1-32-22-18(24)10-16(12-26-22)28-6-7-33-20-13-25-21(11-19(20)28)34-17-2-5-27(14-17)23(29)15-3-8-35(30,31)9-4-15/h10-13,15,17H,2-9,14H2,1H3/t17-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203439
PNG
(US9539260, B94)
Show SMILES COc1ncc(cc1C)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOC3)cc12
Show InChI InChI=1S/C24H29N3O5/c1-16-11-18(13-25-23(16)29-2)27-8-10-31-22-4-3-19(12-21(22)27)32-20-5-7-26(14-20)24(28)17-6-9-30-15-17/h3-4,11-13,17,20H,5-10,14-15H2,1-2H3/t17?,20-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204117
PNG
(US9539260, I2)
Show SMILES COc1ncc(cc1C(F)F)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCS(=O)(=O)CC3)c(F)c12
Show InChI InChI=1S/C25H28F3N3O6S/c1-35-24-18(23(27)28)12-16(13-29-24)31-8-9-36-20-3-2-19(21(26)22(20)31)37-17-4-7-30(14-17)25(32)15-5-10-38(33,34)11-6-15/h2-3,12-13,15,17,23H,4-11,14H2,1H3/t17-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203413
PNG
(US9539260, B69)
Show SMILES CS(=O)(=O)c1ncc(cc1C(F)(F)F)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C25H28F3N3O6S/c1-38(33,34)23-20(25(26,27)28)12-17(14-29-23)31-8-11-36-22-3-2-18(13-21(22)31)37-19-4-7-30(15-19)24(32)16-5-9-35-10-6-16/h2-3,12-14,16,19H,4-11,15H2,1H3/t19-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203898
PNG
(US9539260, C14)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)c3cncs3)cc12
Show InChI InChI=1S/C23H21N5O4S/c1-30-22-15(10-24)8-16(11-26-22)28-6-7-31-20-3-2-17(9-19(20)28)32-18-4-5-27(13-18)23(29)21-12-25-14-33-21/h2-3,8-9,11-12,14,18H,4-7,13H2,1H3/t18-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


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Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204091
PNG
(US9539260, F8)
Show SMILES COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C24H28F2N4O5/c1-32-23-18(22(25)26)10-16(12-28-23)30-6-9-34-20-13-27-21(11-19(20)30)35-17-2-5-29(14-17)24(31)15-3-7-33-8-4-15/h10-13,15,17,22H,2-9,14H2,1H3/t17-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204112
PNG
(US9539260, H13 | US9539260, H14)
Show SMILES COc1ncc(cc1Cl)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCS(=O)(=O)C3)cc12
Show InChI InChI=1S/C23H26ClN3O6S/c1-31-22-19(24)10-16(12-25-22)27-7-8-32-21-3-2-17(11-20(21)27)33-18-4-6-26(13-18)23(28)15-5-9-34(29,30)14-15/h2-3,10-12,15,18H,4-9,13-14H2,1H3/t15?,18-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM202514
PNG
(US9539260, A13)
Show SMILES CCC(=O)N1CC[C@@H](C1)Oc1ccc2OCCN(c3cnc(OC)c(C)c3)c2c1
Show InChI InChI=1S/C22H27N3O4/c1-4-21(26)24-8-7-18(14-24)29-17-5-6-20-19(12-17)25(9-10-28-20)16-11-15(2)22(27-3)23-13-16/h5-6,11-13,18H,4,7-10,14H2,1-3H3/t18-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203359
PNG
(US9539260, B22)
Show SMILES Cc1cc(cnc1S(C)(=O)=O)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)c3ccncc3)cc12
Show InChI InChI=1S/C25H26N4O5S/c1-17-13-19(15-27-24(17)35(2,31)32)29-11-12-33-23-4-3-20(14-22(23)29)34-21-7-10-28(16-21)25(30)18-5-8-26-9-6-18/h3-6,8-9,13-15,21H,7,10-12,16H2,1-2H3/t21-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204062
PNG
(US9539260, D28 | US9539260, D29)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOC3)cc12
Show InChI InChI=1S/C24H26N4O5/c1-30-23-17(12-25)10-18(13-26-23)28-7-9-32-22-3-2-19(11-21(22)28)33-20-4-6-27(14-20)24(29)16-5-8-31-15-16/h2-3,10-11,13,16,20H,4-9,14-15H2,1H3/t16?,20-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM204106
PNG
(US9539260, H7 | US9539260, H8)
Show SMILES COc1cc(cnc1OC)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCCO3)cc12
Show InChI InChI=1S/C24H29N3O6/c1-29-22-12-16(14-25-23(22)30-2)27-9-11-32-20-6-5-17(13-19(20)27)33-18-7-8-26(15-18)24(28)21-4-3-10-31-21/h5-6,12-14,18,21H,3-4,7-11,15H2,1-2H3/t18-,21?/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203415
PNG
(US9539260, B71)
Show SMILES CS(=O)(=O)c1ncc(cc1CF)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C25H30FN3O6S/c1-36(31,32)24-18(14-26)12-19(15-27-24)29-8-11-34-23-3-2-20(13-22(23)29)35-21-4-7-28(16-21)25(30)17-5-9-33-10-6-17/h2-3,12-13,15,17,21H,4-11,14,16H2,1H3/t21-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM202488
PNG
(US9539260, A2)
Show SMILES CN(C)S(=O)(=O)c1cncc(c1)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C25H32N4O6S/c1-27(2)36(31,32)22-13-19(15-26-16-22)29-9-12-34-24-4-3-20(14-23(24)29)35-21-5-8-28(17-21)25(30)18-6-10-33-11-7-18/h3-4,13-16,18,21H,5-12,17H2,1-2H3/t21-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203880
PNG
(US9539260, B119)
Show SMILES COc1ncc(cc1C(F)F)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCS(=O)(=O)CC3)cc12
Show InChI InChI=1S/C25H29F2N3O6S/c1-34-24-20(23(26)27)12-17(14-28-24)30-8-9-35-22-3-2-18(13-21(22)30)36-19-4-7-29(15-19)25(31)16-5-10-37(32,33)11-6-16/h2-3,12-14,16,19,23H,4-11,15H2,1H3/t19-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203881
PNG
(US9539260, B120)
Show SMILES COc1ncc(cc1C(F)F)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C25H29F2N3O5/c1-32-24-20(23(26)27)12-17(14-28-24)30-8-11-34-22-3-2-18(13-21(22)30)35-19-4-7-29(15-19)25(31)16-5-9-33-10-6-16/h2-3,12-14,16,19,23H,4-11,15H2,1H3/t19-/m0/s1
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US Patent


Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM203904
PNG
(US9539260, C20)
Show SMILES COc1ncc(cc1C#N)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)c3oc(C)nc3C)cc12
Show InChI InChI=1S/C25H25N5O5/c1-15-23(34-16(2)28-15)25(31)29-7-6-20(14-29)35-19-4-5-22-21(11-19)30(8-9-33-22)18-10-17(12-26)24(32-3)27-13-18/h4-5,10-11,13,20H,6-9,14H2,1-3H3/t20-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM202487
PNG
(US9539260, A1)
Show SMILES COc1ncc(cc1C)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12
Show InChI InChI=1S/C25H31N3O5/c1-17-13-19(15-26-24(17)30-2)28-9-12-32-23-4-3-20(14-22(23)28)33-21-5-8-27(16-21)25(29)18-6-10-31-11-7-18/h3-4,13-15,18,21H,5-12,16H2,1-2H3/t21-/m0/s1
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Assay Description
Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...


Citation and Details
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%