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Found 14 Enz. Inhib. hit(s) with all data for entry = 171
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200951(6-[4-(isoquinolin-1-yloxy)-2-methylphenyl]-1,5-dim...)
Affinity DataKi:  1.90nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200985(5-[4-(isoquinolin-1-yloxy)-2-methylphenyl]- 4,6-di...)
Affinity DataKi:  7.80nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200843(1,5-dimethyl-6-[2-methyl-4-(1,7-naphthyridin-8-ylo...)
Affinity DataKi:  28.5nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200931((−)-4,6-dimethyl-5-[2-methyl-4-(1,7-naphthyr...)
Affinity DataKi:  102nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200975(8-[4-(4,6-dimethylpyrimidin-5-yl)-3- methylphenoxy...)
Affinity DataKi:  105nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
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TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200895((+)-4,6-dimethyl-5-[2-methyl-4-(1,7-naphthyridin-8...)
Affinity DataKi:  115nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200976(1,5-dimethyl-6-[4-(1,7-naphthyridin-8-yloxy) pheny...)
Affinity DataKi:  119nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200983(4,6-dimethyl-5-[2-methyl-4-(1,6-naphthyridin- 5-yl...)
Affinity DataKi:  124nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200977(4,6-dimethyl-5-[2-methyl-4-(2,7-naphthyridin- 1-yl...)
Affinity DataKi:  141nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200988(5-{4-[(7-methoxyisoquinolin-1-yl)oxy]-2-methylphen...)
Affinity DataKi:  186nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200936(4,6-dimethyl-5-[4-(1,7-naphthyridin-8-yloxy)phenyl...)
Affinity DataKi:  205nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200990(1-[4-(3,5-dimethyl-6-oxo-1,6- dihydropyridazin-4-y...)
Affinity DataKi:  261nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200978(4,6-dimethyl-5-[2-methyl-4-(pyrido[3,4-b] pyrazin-...)
Affinity DataKi:  306nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200989(1-[4-(3,5-dimethyl-6-oxo-1,6- 4dihydropyridazin--y...)
Affinity DataKi:  334nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent