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Patent code US9540384

Compile Data Set for Download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201605
PNG
(4-(6-chloro-2-((6-(pyrrolidin-1-yl)pyridin-2-yl)me...)
Show SMILES Clc1ccc2nc(OCc3cccc(n3)N3CCCC3)nc(N3CCOCC3)c2c1
Show InChI InChI=1S/C22H24ClN5O2/c23-16-6-7-19-18(14-16)21(28-10-12-29-13-11-28)26-22(25-19)30-15-17-4-3-5-20(24-17)27-8-1-2-9-27/h3-7,14H,1-2,8-13,15H2
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n/an/a 2.5n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201626
PNG
(4-(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)...)
Show SMILES Clc1ccc2nc(CCc3cccc(n3)N3CCCC3)nc(N3CCOCC3)c2c1
Show InChI InChI=1S/C23H26ClN5O/c24-17-6-8-20-19(16-17)23(29-12-14-30-15-13-29)27-21(26-20)9-7-18-4-3-5-22(25-18)28-10-1-2-11-28/h3-6,8,16H,1-2,7,9-15H2
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n/an/a 3.30n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202244
PNG
(5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl...)
Show SMILES Cc1cnc(C)c2nc(CCc3cccc(n3)N3CCCC3)nn12
Show InChI InChI=1S/C18H22N6/c1-13-12-19-14(2)18-21-16(22-24(13)18)9-8-15-6-5-7-17(20-15)23-10-3-4-11-23/h5-7,12H,3-4,8-11H2,1-2H3
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n/an/a 4.5n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201625
PNG
((e)-4-(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2...)
Show SMILES Clc1ccc2nc(\C=C\c3cccc(n3)N3CCCC3)nc(N3CCOCC3)c2c1
Show InChI InChI=1S/C23H24ClN5O/c24-17-6-8-20-19(16-17)23(29-12-14-30-15-13-29)27-21(26-20)9-7-18-4-3-5-22(25-18)28-10-1-2-11-28/h3-9,16H,1-2,10-15H2/b9-7+
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n/an/a 6.30n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201613
PNG
(6-chloro-n,n-dimethyl-2-((6-(pyrrolidin-1-yl)pyrid...)
Show SMILES CN(C)c1nc(OCc2cccc(n2)N2CCCC2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C20H22ClN5O/c1-25(2)19-16-12-14(21)8-9-17(16)23-20(24-19)27-13-15-6-5-7-18(22-15)26-10-3-4-11-26/h5-9,12H,3-4,10-11,13H2,1-2H3
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n/an/a 7n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202236
PNG
((e)-5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-...)
Show SMILES Cc1cnc(C)c2nc(\C=C\c3cccc(n3)N3CCCC3)nn12
Show InChI InChI=1S/C18H20N6/c1-13-12-19-14(2)18-21-16(22-24(13)18)9-8-15-6-5-7-17(20-15)23-10-3-4-11-23/h5-9,12H,3-4,10-11H2,1-2H3/b9-8+
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n/an/a 12n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202255
PNG
((e)-5,8-dim ethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin...)
Show SMILES Cc1cnc(C)c2nc(\C=C\c3cncc(n3)N3CCCC3)nn12
Show InChI InChI=1S/C17H19N7/c1-12-9-19-13(2)17-21-15(22-24(12)17)6-5-14-10-18-11-16(20-14)23-7-3-4-8-23/h5-6,9-11H,3-4,7-8H2,1-2H3/b6-5+
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n/an/a 18n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202195
PNG
((e)-6-chloro-n,n-dimethyl-2-(2-(6-(2-methylpyrroli...)
Show SMILES CC1CCCN1c1cccc(\C=C\c2nc(N(C)C)c3cc(Cl)ccc3n2)n1
Show InChI InChI=1S/C22H24ClN5/c1-15-6-5-13-28(15)21-8-4-7-17(24-21)10-12-20-25-19-11-9-16(23)14-18(19)22(26-20)27(2)3/h4,7-12,14-15H,5-6,13H2,1-3H3/b12-10+
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n/an/a 27n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201598
PNG
(2-methyl-3-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Show SMILES Cc1nc2ccccc2nc1OCc1cccc(n1)N1CCCC1
Show InChI InChI=1S/C19H20N4O/c1-14-19(22-17-9-3-2-8-16(17)20-14)24-13-15-7-6-10-18(21-15)23-11-4-5-12-23/h2-3,6-10H,4-5,11-13H2,1H3
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Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202252
PNG
((e)-5,7-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-...)
Show SMILES Cc1cc(C)n2nc(\C=C\c3cccc(n3)N3CCCC3)nc2n1
Show InChI InChI=1S/C18H20N6/c1-13-12-14(2)24-18(19-13)21-16(22-24)9-8-15-6-5-7-17(20-15)23-10-3-4-11-23/h5-9,12H,3-4,10-11H2,1-2H3/b9-8+
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n/an/a 31n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201629
PNG
(4-(2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)ethyl)qui...)
Show SMILES C(Cc1nc(N2CCOCC2)c2ccccc2n1)c1cccc(n1)N1CCCC1
Show InChI InChI=1S/C23H27N5O/c1-2-8-20-19(7-1)23(28-14-16-29-17-15-28)26-21(25-20)11-10-18-6-5-9-22(24-18)27-12-3-4-13-27/h1-2,5-9H,3-4,10-17H2
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Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201612
PNG
(4-(2-((6-(pyrrolidin-1-yl)pyridin-2-yl)methoxy)qui...)
Show SMILES C(Oc1nc(N2CCOCC2)c2ccccc2n1)c1cccc(n1)N1CCCC1
Show InChI InChI=1S/C22H25N5O2/c1-2-8-19-18(7-1)21(27-12-14-28-15-13-27)25-22(24-19)29-16-17-6-5-9-20(23-17)26-10-3-4-11-26/h1-2,5-9H,3-4,10-16H2
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Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202279
PNG
(2,3-dimethyl-5-((6-(pyrrolidin-1-yl)pyridin-2-yl)m...)
Show SMILES Cc1nn2ccc(OCc3cccc(n3)N3CCCC3)nc2c1C
Show InChI InChI=1S/C18H21N5O/c1-13-14(2)21-23-11-8-17(20-18(13)23)24-12-15-6-5-7-16(19-15)22-9-3-4-10-22/h5-8,11H,3-4,9-10,12H2,1-2H3
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n/an/a 69n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202231
PNG
(6-chloro-n,n-dimethyl-2-(2-(6-(2-methylpyrrolidin-...)
Show SMILES CC1CCCN1c1cccc(CCc2nc(N(C)C)c3cc(Cl)ccc3n2)n1
Show InChI InChI=1S/C22H26ClN5/c1-15-6-5-13-28(15)21-8-4-7-17(24-21)10-12-20-25-19-11-9-16(23)14-18(19)22(26-20)27(2)3/h4,7-9,11,14-15H,5-6,10,12-13H2,1-3H3
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n/an/a 81n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201599
PNG
(2-methyl-3-[(e)-2-(6-pyrrolidin-1-yl-pyridin-2-yl)...)
Show SMILES Cc1nc2ccccc2nc1\C=C\c1cccc(n1)N1CCCC1
Show InChI InChI=1S/C20H20N4/c1-15-17(23-19-9-3-2-8-18(19)21-15)12-11-16-7-6-10-20(22-16)24-13-4-5-14-24/h2-3,6-12H,4-5,13-14H2,1H3/b12-11+
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Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201630
PNG
(6-chloro-2-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Show SMILES Clc1ccc2nc(OCc3cccc(n3)N3CCCC3)nc(OC3CCCOC3)c2c1
Show InChI InChI=1S/C23H25ClN4O3/c24-16-8-9-20-19(13-16)22(31-18-6-4-12-29-15-18)27-23(26-20)30-14-17-5-3-7-21(25-17)28-10-1-2-11-28/h3,5,7-9,13,18H,1-2,4,6,10-12,14-15H2
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n/an/a 94n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202032
PNG
(6-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)eth...)
Show SMILES Clc1ccc2nc(CCc3cccc(n3)N3CCCC3)[nH]c(=O)c2c1
Show InChI InChI=1S/C19H19ClN4O/c20-13-6-8-16-15(12-13)19(25)23-17(22-16)9-7-14-4-3-5-18(21-14)24-10-1-2-11-24/h3-6,8,12H,1-2,7,9-11H2,(H,22,23,25)
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n/an/a 100n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202253
PNG
(5,7-dimethyl-2-[2-(6-pyrrolidin-1-yl-pyridin-2-yl)...)
Show SMILES Cc1cc(C)n2nc(CCc3cccc(n3)N3CCCC3)nc2n1
Show InChI InChI=1S/C18H22N6/c1-13-12-14(2)24-18(19-13)21-16(22-24)9-8-15-6-5-7-17(20-15)23-10-3-4-11-23/h5-7,12H,3-4,8-11H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201606
PNG
(2-(2-(1-methyl-4-phenyl-1h-imidazol-2-yl)ethyl)-6-...)
Show SMILES Cn1cc(nc1CCc1cncc(n1)N1CCCN1)-c1ccccc1
Show InChI InChI=1S/C19H22N6/c1-24-14-17(15-6-3-2-4-7-15)23-18(24)9-8-16-12-20-13-19(22-16)25-11-5-10-21-25/h2-4,6-7,12-14,21H,5,8-11H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201603
PNG
(2-methyl-3-[2-(6-pyrrolidin-1-yl-pyridin-2-yl)-eth...)
Show SMILES Cc1nc2ccccc2nc1CCc1cccc(n1)N1CCCC1
Show InChI InChI=1S/C20H22N4/c1-15-17(23-19-9-3-2-8-18(19)21-15)12-11-16-7-6-10-20(22-16)24-13-4-5-14-24/h2-3,6-10H,4-5,11-14H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202277
PNG
(5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl...)
Show SMILES Cc1cnc(C)c2nc(CCc3cncc(n3)N3CCCC3)nn12
Show InChI InChI=1S/C17H21N7/c1-12-9-19-13(2)17-21-15(22-24(12)17)6-5-14-10-18-11-16(20-14)23-7-3-4-8-23/h9-11H,3-8H2,1-2H3
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n/an/a 140n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202081
PNG
((1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin-2-y...)
Show SMILES CN(C)c1nc(CCc2cccc(n2)N2CCC(CO)C2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C22H26ClN5O/c1-27(2)22-18-12-16(23)6-8-19(18)25-20(26-22)9-7-17-4-3-5-21(24-17)28-11-10-15(13-28)14-29/h3-6,8,12,15,29H,7,9-11,13-14H2,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202243
PNG
(2,3-dimethyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)m...)
Show SMILES Cc1nc2ccc(OCc3cccc(n3)N3CCCC3)nn2c1C
Show InChI InChI=1S/C18H21N5O/c1-13-14(2)23-17(19-13)8-9-18(21-23)24-12-15-6-5-7-16(20-15)22-10-3-4-11-22/h5-9H,3-4,10-12H2,1-2H3
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n/an/a 160n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202286
PNG
(3-methyl-n-((6-(pyrrolidin-1-yl)pyridin-2-yl)methy...)
Show SMILES Cc1c(nc2ccc(NCc3cccc(n3)N3CCCC3)nn12)C(F)(F)F
Show InChI InChI=1S/C18H19F3N6/c1-12-17(18(19,20)21)24-16-8-7-14(25-27(12)16)22-11-13-5-4-6-15(23-13)26-9-2-3-10-26/h4-8H,2-3,9-11H2,1H3,(H,22,25)
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n/an/a 200n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202028
PNG
((e)-(1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin...)
Show SMILES CN(C)c1nc(\C=C\c2cccc(n2)N2CCC(CO)C2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C22H24ClN5O/c1-27(2)22-18-12-16(23)6-8-19(18)25-20(26-22)9-7-17-4-3-5-21(24-17)28-11-10-15(13-28)14-29/h3-9,12,15,29H,10-11,13-14H2,1-2H3/b9-7+
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n/an/a 220n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202232
PNG
((e)-2-((6-(2-(6-chloro-4-(dimethylamino)quinazolin...)
Show SMILES CN(C)c1nc(\C=C\c2cccc(n2)N(C)CCO)nc2ccc(Cl)cc12
Show InChI InChI=1S/C20H22ClN5O/c1-25(2)20-16-13-14(21)7-9-17(16)23-18(24-20)10-8-15-5-4-6-19(22-15)26(3)11-12-27/h4-10,13,27H,11-12H2,1-3H3/b10-8+
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n/an/a 240n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202280
PNG
(2-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Show SMILES Cc1cn2nc(OCc3cccc(n3)N3CCCC3)ccc2n1
Show InChI InChI=1S/C17H19N5O/c1-13-11-22-16(18-13)7-8-17(20-22)23-12-14-5-4-6-15(19-14)21-9-2-3-10-21/h4-8,11H,2-3,9-10,12H2,1H3
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n/an/a 260n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201624
PNG
(4-(1-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)me...)
Show SMILES Cn1ncc2c(nc(OCc3cccc(n3)N3CCCC3)nc12)N1CCOCC1
Show InChI InChI=1S/C20H25N7O2/c1-25-18-16(13-21-25)19(27-9-11-28-12-10-27)24-20(23-18)29-14-15-5-4-6-17(22-15)26-7-2-3-8-26/h4-6,13H,2-3,7-12,14H2,1H3
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n/an/a 276n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202251
PNG
(5,7-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl...)
Show SMILES Cc1cc(C)n2nc(CCc3cncc(n3)N3CCCC3)nc2n1
Show InChI InChI=1S/C17H21N7/c1-12-9-13(2)24-17(19-12)21-15(22-24)6-5-14-10-18-11-16(20-14)23-7-3-4-8-23/h9-11H,3-8H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202287
PNG
(2,3-dimethyl-5-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl...)
Show SMILES Cc1nn2ccc(CCc3cccc(n3)N3CCCC3)nc2c1C
Show InChI InChI=1S/C19H23N5/c1-14-15(2)22-24-13-10-17(21-19(14)24)9-8-16-6-5-7-18(20-16)23-11-3-4-12-23/h5-7,10,13H,3-4,8-9,11-12H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202029
PNG
(5-chloro-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)eth...)
Show SMILES Clc1cccc2nc(CCc3cccc(n3)N3CCCC3)[nH]c(=O)c12
Show InChI InChI=1S/C19H19ClN4O/c20-14-6-4-7-15-18(14)19(25)23-16(22-15)10-9-13-5-3-8-17(21-13)24-11-1-2-12-24/h3-8H,1-2,9-12H2,(H,22,23,25)
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n/an/a 400n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202030
PNG
(6-chloro-5-methoxy-2-(2-(6-(pyrrolidin-1-yl)pyridi...)
Show SMILES COc1c(Cl)ccc2nc(CCc3cccc(n3)N3CCCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H21ClN4O2/c1-27-19-14(21)8-9-15-18(19)20(26)24-16(23-15)10-7-13-5-4-6-17(22-13)25-11-2-3-12-25/h4-6,8-9H,2-3,7,10-12H2,1H3,(H,23,24,26)
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n/an/a 470n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202035
PNG
(1-(6-(2-(4-(dimethylamino)quinazolin-2-yl)ethyl)py...)
Show SMILES CN(C)c1nc(CCc2cccc(n2)N2CCC(O)C2)nc2ccccc12
Show InChI InChI=1S/C21H25N5O/c1-25(2)21-17-7-3-4-8-18(17)23-19(24-21)11-10-15-6-5-9-20(22-15)26-13-12-16(27)14-26/h3-9,16,27H,10-14H2,1-2H3
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n/an/a 480n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201551
PNG
((E)-2-[2-(4-Methyl-6-pyrrolidin-1-yl-pyrimidin-2-y...)
Show SMILES Cc1cc(nc(\C=C\c2ccc3ccccc3n2)n1)N1CCCC1
Show InChI InChI=1S/C20H20N4/c1-15-14-20(24-12-4-5-13-24)23-19(21-15)11-10-17-9-8-16-6-2-3-7-18(16)22-17/h2-3,6-11,14H,4-5,12-13H2,1H3/b11-10+
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n/an/a 530n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202278
PNG
(2-ethyl-3-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-...)
Show SMILES CCc1nc2ccc(OCc3cccc(n3)N3CCCC3)nn2c1C
Show InChI InChI=1S/C19H23N5O/c1-3-16-14(2)24-18(21-16)9-10-19(22-24)25-13-15-7-6-8-17(20-15)23-11-4-5-12-23/h6-10H,3-5,11-13H2,1-2H3
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n/an/a 540n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201597
PNG
(2,3,5-trimethyl-6-(2-(6-(pyrrolidin-1-yl)pyridin-2...)
Show SMILES Cc1nc(C)c(CCc2cccc(n2)N2CCCC2)nc1C
Show InChI InChI=1S/C18H24N4/c1-13-14(2)20-17(15(3)19-13)10-9-16-7-6-8-18(21-16)22-11-4-5-12-22/h6-8H,4-5,9-12H2,1-3H3
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n/an/a 600n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202284
PNG
(2-cyclopropyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)...)
Show SMILES C(Oc1ccc2nc(cn2n1)C1CC1)c1cccc(n1)N1CCCC1
Show InChI InChI=1S/C19H21N5O/c1-2-11-23(10-1)17-5-3-4-15(20-17)13-25-19-9-8-18-21-16(14-6-7-14)12-24(18)22-19/h3-5,8-9,12,14H,1-2,6-7,10-11,13H2
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n/an/a 600n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201593
PNG
(4-methoxy-3,5-dimethyl-2-(2-(6-(pyrrolidin-1-yl)py...)
Show SMILES COc1c(C)cnc(CCc2cccc(n2)N2CCCC2)c1C
Show InChI InChI=1S/C19H25N3O/c1-14-13-20-17(15(2)19(14)23-3)10-9-16-7-6-8-18(21-16)22-11-4-5-12-22/h6-8,13H,4-5,9-12H2,1-3H3
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n/an/a 610n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202254
PNG
(2,3-dmethyl-6-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)...)
Show SMILES Cc1nc2ccc(CCc3cccc(n3)N3CCCC3)nn2c1C
Show InChI InChI=1S/C19H23N5/c1-14-15(2)24-19(20-14)11-10-17(22-24)9-8-16-6-5-7-18(21-16)23-12-3-4-13-23/h5-7,10-11H,3-4,8-9,12-13H2,1-2H3
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n/an/a 630n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202234
PNG
((e)-6-chloro-2-(2-(6-(dimethylamino)pyridin-2-yl)v...)
Show SMILES CN(C)c1cccc(\C=C\c2nc(N(C)C)c3cc(Cl)ccc3n2)n1
Show InChI InChI=1S/C19H20ClN5/c1-24(2)18-7-5-6-14(21-18)9-11-17-22-16-10-8-13(20)12-15(16)19(23-17)25(3)4/h5-12H,1-4H3/b11-9+
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n/an/a 750n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202034
PNG
(1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin-2-yl...)
Show SMILES CN(C)c1nc(CCc2cccc(n2)N2CCC(O)C2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H24ClN5O/c1-26(2)21-17-12-14(22)6-8-18(17)24-19(25-21)9-7-15-4-3-5-20(23-15)27-11-10-16(28)13-27/h3-6,8,12,16,28H,7,9-11,13H2,1-2H3
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n/an/a 770n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201554
PNG
((e)-4-methoxy-3,5-dimethyl-2-(2-(6-(pyrrolidin-1-y...)
Show SMILES COc1c(C)cnc(\C=C\c2cccc(n2)N2CCCC2)c1C
Show InChI InChI=1S/C19H23N3O/c1-14-13-20-17(15(2)19(14)23-3)10-9-16-7-6-8-18(21-16)22-11-4-5-12-22/h6-10,13H,4-5,11-12H2,1-3H3/b10-9+
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n/an/a 790n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202217
PNG
((e)-1-(6-(2-(6-chloro-4-(dimethylamino)quinazolin-...)
Show SMILES CN(C)c1nc(\C=C\c2cccc(n2)N2CCCC2=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H20ClN5O/c1-26(2)21-16-13-14(22)8-10-17(16)24-18(25-21)11-9-15-5-3-6-19(23-15)27-12-4-7-20(27)28/h3,5-6,8-11,13H,4,7,12H2,1-2H3/b11-9+
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n/an/a 820n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202285
PNG
(3-methyl-6-((6-(pyrrolidin-1-yl)pyridin-2-yl)metho...)
Show SMILES Cc1c(nc2ccc(OCc3cccc(n3)N3CCCC3)nn12)C(N)=O
Show InChI InChI=1S/C18H20N6O2/c1-12-17(18(19)25)21-15-7-8-16(22-24(12)15)26-11-13-5-4-6-14(20-13)23-9-2-3-10-23/h4-8H,2-3,9-11H2,1H3,(H2,19,25)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201631
PNG
(4-[2-(2h-pyrazol-3-yl)-6-(6-pyrrolidin-1-yl-pyridi...)
Show SMILES C(Oc1cc(nc(n1)-c1ccn[nH]1)N1CCOCC1)c1cccc(n1)N1CCCC1
Show InChI InChI=1S/C21H25N7O2/c1-2-9-27(8-1)18-5-3-4-16(23-18)15-30-20-14-19(28-10-12-29-13-11-28)24-21(25-20)17-6-7-22-26-17/h3-7,14H,1-2,8-13,15H2,(H,22,26)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202146
PNG
((1-(6-(2-(4-(dimethylamino)quinazolin-2-yl)ethyl)p...)
Show SMILES CN(C)c1nc(CCc2cccc(n2)N2CCC(CO)C2)nc2ccccc12
Show InChI InChI=1S/C22H27N5O/c1-26(2)22-18-7-3-4-8-19(18)24-20(25-22)11-10-17-6-5-9-21(23-17)27-13-12-16(14-27)15-28/h3-9,16,28H,10-15H2,1-2H3
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n/an/a 1.63E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202027
PNG
(4-(2-(pyridin-3-yl)-6-((6-(pyrrolidin-1-yl)pyridin...)
Show SMILES C(Oc1cc(nc(n1)-c1cccnc1)N1CCOCC1)c1cccc(n1)N1CCCC1
Show InChI InChI=1S/C23H26N6O2/c1-2-10-28(9-1)20-7-3-6-19(25-20)17-31-22-15-21(29-11-13-30-14-12-29)26-23(27-22)18-5-4-8-24-16-18/h3-8,15-16H,1-2,9-14,17H2
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n/an/a 1.63E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202235
PNG
(6-chloro-2-(2-(6-(dimethylamino)pyridin-2-yl)ethyl...)
Show SMILES CN(C)c1cccc(CCc2nc(N(C)C)c3cc(Cl)ccc3n2)n1
Show InChI InChI=1S/C19H22ClN5/c1-24(2)18-7-5-6-14(21-18)9-11-17-22-16-10-8-13(20)12-15(16)19(23-17)25(3)4/h5-8,10,12H,9,11H2,1-4H3
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n/an/a 1.68E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201611
PNG
(2-methyl-3-((6-(piperidin-1-yl)pyridin-2-yl)methox...)
Show SMILES Cc1nc2ccccc2nc1OCc1cccc(n1)N1CCCCC1
Show InChI InChI=1S/C20H22N4O/c1-15-20(23-18-10-4-3-9-17(18)21-15)25-14-16-8-7-11-19(22-16)24-12-5-2-6-13-24/h3-4,7-11H,2,5-6,12-14H2,1H3
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n/an/a 1.68E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201594
PNG
(2-(2-(1-methyl-4-phenyl-1h-imidazol-2-yl)ethyl)-6-...)
Show SMILES Cn1cc(nc1CCc1cccc(n1)N1CCCC1)-c1ccccc1
Show InChI InChI=1S/C21H24N4/c1-24-16-19(17-8-3-2-4-9-17)23-20(24)13-12-18-10-7-11-21(22-18)25-14-5-6-15-25/h2-4,7-11,16H,5-6,12-15H2,1H3
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n/an/a 1.84E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201604
PNG
(2-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethyl]-6-pyrr...)
Show SMILES Cc1oc(nc1CCc1cccc(n1)N1CCCC1)-c1ccccc1
Show InChI InChI=1S/C21H23N3O/c1-16-19(23-21(25-16)17-8-3-2-4-9-17)13-12-18-10-7-11-20(22-18)24-14-5-6-15-24/h2-4,7-11H,5-6,12-15H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202233
PNG
(2-((6-(2-(6-chloro-4-(dimethylamino)quinazolin-2-y...)
Show SMILES CN(C)c1nc(CCc2cccc(n2)N(C)CCO)nc2ccc(Cl)cc12
Show InChI InChI=1S/C20H24ClN5O/c1-25(2)20-16-13-14(21)7-9-17(16)23-18(24-20)10-8-15-5-4-6-19(22-15)26(3)11-12-27/h4-7,9,13,27H,8,10-12H2,1-3H3
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n/an/a 2.16E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202033
PNG
(2-(2-(6-(2,5-dimethylpyrrolidin-1-yl)pyridin-2-yl)...)
Show SMILES CC1CCC(C)N1c1cccc(CCc2nc(N(C)C)c3ccccc3n2)n1
Show InChI InChI=1S/C23H29N5/c1-16-12-13-17(2)28(16)22-11-7-8-18(24-22)14-15-21-25-20-10-6-5-9-19(20)23(26-21)27(3)4/h5-11,16-17H,12-15H2,1-4H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202031
PNG
(7,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl...)
Show SMILES Cc1nc2nc(CCc3cccc(n3)N3CCCC3)[nH]c(=O)c2n1C
Show InChI InChI=1S/C18H22N6O/c1-12-19-17-16(23(12)2)18(25)22-14(21-17)9-8-13-6-5-7-15(20-13)24-10-3-4-11-24/h5-7H,3-4,8-11H2,1-2H3,(H,21,22,25)
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n/an/a 2.73E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201596
PNG
(4-(6-(2-(1-methyl-4-phenyl-1h-imidazol-2-yl)ethyl)...)
Show SMILES Cn1cc(nc1CCc1cccc(n1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C21H24N4O/c1-24-16-19(17-6-3-2-4-7-17)23-20(24)11-10-18-8-5-9-21(22-18)25-12-14-26-15-13-25/h2-9,16H,10-15H2,1H3
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n/an/a 3.14E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM202221
PNG
(8-methyl-2-(2-(6-(pyrrolidin-1-yl)pyridin-2-yl)eth...)
Show SMILES Cc1cccc2c1nc(CCc1cccc(n1)N1CCCC1)[nH]c2=O
Show InChI InChI=1S/C20H22N4O/c1-14-6-4-8-16-19(14)22-17(23-20(16)25)11-10-15-7-5-9-18(21-15)24-12-2-3-13-24/h4-9H,2-3,10-13H2,1H3,(H,22,23,25)
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n/an/a 3.27E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201555
PNG
(US9540384, 4 | methyl-{6-[2-(1-methyl-4-phenyl-1h-...)
Show SMILES CNc1cccc(CCc2nc(cn2C)-c2ccccc2)n1
Show InChI InChI=1S/C18H20N4/c1-19-17-10-6-9-15(20-17)11-12-18-21-16(13-22(18)2)14-7-4-3-5-8-14/h3-10,13H,11-12H2,1-2H3,(H,19,20)
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n/an/a 4.06E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM201553
PNG
((e)-4-(6-(2-(4-methoxy-3,5-dimethylpyridin-2-yl)vi...)
Show SMILES COc1c(C)cnc(\C=C\c2cccc(n2)N2CCOCC2)c1C
Show InChI InChI=1S/C19H23N3O2/c1-14-13-20-17(15(2)19(14)23-3)8-7-16-5-4-6-18(21-16)22-9-11-24-12-10-22/h4-8,13H,9-12H2,1-3H3/b8-7+
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n/an/a 8.00E+3n/an/an/an/an/an/a



Hoffmann-La Roche, Inc.

US Patent


Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...


US Patent US9540384 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%