BindingDB logo
myBDB logout

Patent code US9550755

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
human factor d


(Homo sapiens (Human))
BDBM204930
PNG
(1-{2-oxo-2-[(1R,3S,5R)-3-{[1-(trifluoromethyl)-1H-...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2ccn(n2)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C20H18F3N7O3/c21-20(22,23)29-6-5-15(26-29)25-19(33)14-8-10-7-13(10)30(14)16(31)9-28-12-4-2-1-3-11(12)17(27-28)18(24)32/h1-6,10,13-14H,7-9H2,(H2,24,32)(H,25,26,33)/t10-,13-,14+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
human factor d


(Homo sapiens (Human))
BDBM204926
PNG
(1-{2-oxo-2-[(1R,3S,5R)-3-{[1-(2,2,2-trifluoroethyl...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2ccn(CC(F)(F)F)n2)c2ccccc12
Show InChI InChI=1S/C21H20F3N7O3/c22-21(23,24)10-29-6-5-16(27-29)26-20(34)15-8-11-7-14(11)31(15)17(32)9-30-13-4-2-1-3-12(13)18(28-30)19(25)33/h1-6,11,14-15H,7-10H2,(H2,25,33)(H,26,27,34)/t11-,14-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 64n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
human factor d


(Homo sapiens (Human))
BDBM204928
PNG
((1r,3s,5r)-2-(2-(3-acetyl- 1h-pyrazolo[3,4-c]pyrid...)
Show SMILES CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2ccn(CC(F)(F)F)n2)c2cnccc12
Show InChI InChI=1S/C21H20F3N7O3/c1-11(32)19-13-2-4-25-8-16(13)30(28-19)9-18(33)31-14-6-12(14)7-15(31)20(34)26-17-3-5-29(27-17)10-21(22,23)24/h2-5,8,12,14-15H,6-7,9-10H2,1H3,(H,26,27,34)/t12-,14-,15+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 83n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
human factor d


(Homo sapiens (Human))
BDBM204927
PNG
(1-(2-oxo-2-((1r,3s,5r)-3-((1- (2,2,2-trifluoroethy...)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2ccn(CC(F)(F)F)n2)c2cnccc12
Show InChI InChI=1S/C20H19F3N8O3/c21-20(22,23)9-29-4-2-15(27-29)26-19(34)13-6-10-5-12(10)31(13)16(32)8-30-14-7-25-3-1-11(14)17(28-30)18(24)33/h1-4,7,10,12-13H,5-6,8-9H2,(H2,24,33)(H,26,27,34)/t10-,12-,13+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 98n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
Factor D


(Homo sapiens (Human))
BDBM204929
PNG
(1-(2-((1R,3S,5R)-3-(1- isopropyl-1H-pyrazol-3- ylc...)
Show SMILES CC(C)n1ccc(NC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(N)=O)c3ccccc23)n1
Show InChI InChI=1S/C22H25N7O3/c1-12(2)27-8-7-18(25-27)24-22(32)17-10-13-9-16(13)29(17)19(30)11-28-15-6-4-3-5-14(15)20(26-28)21(23)31/h3-8,12-13,16-17H,9-11H2,1-2H3,(H2,23,31)(H,24,25,32)/t13-,16-,17+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%