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Patent code US9550775

Compile Data Set for Download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268528
PNG
(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Show SMILES Clc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C19H18Cl2N4O3S/c20-13-6-14(21)8-15(7-13)28-10-12-5-18-22-23-19(24-29(26,27)16-3-4-16)25(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,23,24)
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n/an/a 2n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268599
PNG
(N-(6-cyclopropyl-7-((3,5,7-trimethyladamantan-1-yl...)
Show SMILES CC12CC3(C)CC(C)(C1)CC(COc1cc4nnc(NS(C)(=O)=O)n4cc1C1CC1)(C2)C3
Show InChI InChI=1S/C24H34N4O3S/c1-21-9-22(2)11-23(3,10-21)14-24(12-21,13-22)15-31-18-7-19-25-26-20(27-32(4,29)30)28(19)8-17(18)16-5-6-16/h7-8,16H,5-6,9-15H2,1-4H3,(H,26,27)
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n/an/a 2n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268528
PNG
(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Show SMILES Clc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C19H18Cl2N4O3S/c20-13-6-14(21)8-15(7-13)28-10-12-5-18-22-23-19(24-29(26,27)16-3-4-16)25(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,23,24)
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n/an/a 2.05n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268519
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1
Show InChI InChI=1S/C18H16ClF3N4O4S/c1-31(27,28)25-17-24-23-16-4-11(15(8-26(16)17)10-2-3-10)9-29-13-5-12(19)6-14(7-13)30-18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)
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n/an/a 2.5n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268503
PNG
(N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(C)(=O)=O)n3cc1C1CC1)CC2
Show InChI InChI=1S/C20H28N4O3S/c1-20(2)14-7-6-13(16(20)8-14)11-27-17-9-18-21-22-19(23-28(3,25)26)24(18)10-15(17)12-4-5-12/h9-10,12-14,16H,4-8,11H2,1-3H3,(H,22,23)/t13-,14+,16+/m1/s1
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n/an/a 2.60n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268531
PNG
(N-(6-bromo-7-((3,4-dichlorophenoxy)methyl)-[1,2,4]...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(Cl)c3)c(Br)cn12
Show InChI InChI=1S/C14H11BrCl2N4O3S/c1-25(22,23)20-14-19-18-13-4-8(10(15)6-21(13)14)7-24-9-2-3-11(16)12(17)5-9/h2-6H,7H2,1H3,(H,19,20)
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n/an/a 2.60n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268518
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C20H18ClF3N4O4S/c21-13-6-14(8-15(7-13)32-20(22,23)24)31-10-12-5-18-25-26-19(27-33(29,30)16-3-4-16)28(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,26,27)
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n/an/a 2.81n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268418
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(H,25,26)
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n/an/a 2.92n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268518
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C20H18ClF3N4O4S/c21-13-6-14(8-15(7-13)32-20(22,23)24)31-10-12-5-18-25-26-19(27-33(29,30)16-3-4-16)28(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,26,27)
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n/an/a 3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268504
PNG
(N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)C4CC4)n3cc1C1CC1)CC2
Show InChI InChI=1S/C22H30N4O3S/c1-22(2)15-6-5-14(18(22)9-15)12-29-19-10-20-23-24-21(25-30(27,28)16-7-8-16)26(20)11-17(19)13-3-4-13/h10-11,13-16,18H,3-9,12H2,1-2H3,(H,24,25)/t14-,15+,18+/m1/s1
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n/an/a 3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268519
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1
Show InChI InChI=1S/C18H16ClF3N4O4S/c1-31(27,28)25-17-24-23-16-4-11(15(8-26(16)17)10-2-3-10)9-29-13-5-12(19)6-14(7-13)30-18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)
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n/an/a 3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268532
PNG
(N-(7-((1s,3s)-adamantan-1-ylmethoxy)-6-cyclopropyl...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(H,25,26)
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GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268503
PNG
(N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(C)(=O)=O)n3cc1C1CC1)CC2
Show InChI InChI=1S/C20H28N4O3S/c1-20(2)14-7-6-13(16(20)8-14)11-27-17-9-18-21-22-19(23-28(3,25)26)24(18)10-15(17)12-4-5-12/h9-10,12-14,16H,4-8,11H2,1-3H3,(H,22,23)/t13-,14+,16+/m1/s1
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n/an/a 3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268551
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CCC1
Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-2-1-3-19)27-23-26-25-22-9-21(20(13-28(22)23)18-4-5-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-19H,1-8,10-12,14H2,(H,26,27)
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n/an/a 3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268527
PNG
(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1
Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-4-11(15(8-23(16)17)10-2-3-10)9-26-14-6-12(18)5-13(19)7-14/h4-8,10H,2-3,9H2,1H3,(H,21,22)
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n/an/a 3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268527
PNG
(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1
Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-4-11(15(8-23(16)17)10-2-3-10)9-26-14-6-12(18)5-13(19)7-14/h4-8,10H,2-3,9H2,1H3,(H,21,22)
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n/an/a 3.15n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268504
PNG
(N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)C4CC4)n3cc1C1CC1)CC2
Show InChI InChI=1S/C22H30N4O3S/c1-22(2)15-6-5-14(18(22)9-15)12-29-19-10-20-23-24-21(25-30(27,28)16-7-8-16)26(20)11-17(19)13-3-4-13/h10-11,13-16,18H,3-9,12H2,1-2H3,(H,24,25)/t14-,15+,18+/m1/s1
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n/an/a 3.39n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268423
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-20-23-22-19-7-18(17(11-25(19)20)16-2-3-16)28-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16H,2-6,8-10,12H2,1H3,(H,23,24)
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n/an/a 3.69n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268501
PNG
(N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C23H30N4O3S/c28-31(29,17-5-6-17)26-23-25-24-22-10-21(20(11-27(22)23)14-1-2-14)30-12-13-7-18-15-3-4-16(9-15)19(18)8-13/h10-11,13-19H,1-9,12H2,(H,25,26)
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n/an/a 3.71n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268525
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1
Show InChI InChI=1S/C21H20ClF3N4O4S/c1-20(4-5-20)34(30,31)28-19-27-26-18-6-13(17(10-29(18)19)12-2-3-12)11-32-15-7-14(22)8-16(9-15)33-21(23,24)25/h6-10,12H,2-5,11H2,1H3,(H,27,28)
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n/an/a 3.94n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268534
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-20-23-22-19-7-18(17(11-25(19)20)16-2-3-16)28-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16H,2-6,8-10,12H2,1H3,(H,23,24)
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n/an/a 4n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268548
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES CCS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C22H30N4O3S/c1-2-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)
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n/an/a 4n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268525
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1
Show InChI InChI=1S/C21H20ClF3N4O4S/c1-20(4-5-20)34(30,31)28-19-27-26-18-6-13(17(10-29(18)19)12-2-3-12)11-32-15-7-14(22)8-16(9-15)33-21(23,24)25/h6-10,12H,2-5,11H2,1H3,(H,27,28)
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n/an/a 4n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268501
PNG
(N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C23H30N4O3S/c28-31(29,17-5-6-17)26-23-25-24-22-10-21(20(11-27(22)23)14-1-2-14)30-12-13-7-18-15-3-4-16(9-15)19(18)8-13/h10-11,13-19H,1-9,12H2,(H,25,26)
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n/an/a 4n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268490
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES CCS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C22H30N4O3S/c1-2-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)
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n/an/a 4.26n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268526
PNG
(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1
Show InChI InChI=1S/C20H20Cl2N4O3S/c1-20(4-5-20)30(27,28)25-19-24-23-18-6-13(17(10-26(18)19)12-2-3-12)11-29-16-8-14(21)7-15(22)9-16/h6-10,12H,2-5,11H2,1H3,(H,24,25)
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n/an/a 4.87n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268500
PNG
(N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1
Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-21-23-22-20-9-19(18(10-25(20)21)13-2-3-13)28-11-12-6-16-14-4-5-15(8-14)17(16)7-12/h9-10,12-17H,2-8,11H2,1H3,(H,23,24)
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n/an/a 5n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268526
PNG
(N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...)
Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1
Show InChI InChI=1S/C20H20Cl2N4O3S/c1-20(4-5-20)30(27,28)25-19-24-23-18-6-13(17(10-26(18)19)12-2-3-12)11-29-16-8-14(21)7-15(22)9-16/h6-10,12H,2-5,11H2,1H3,(H,24,25)
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n/an/a 5n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268500
PNG
(N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1
Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-21-23-22-20-9-19(18(10-25(20)21)13-2-3-13)28-11-12-6-16-14-4-5-15(8-14)17(16)7-12/h9-10,12-17H,2-8,11H2,1H3,(H,23,24)
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n/an/a 5.24n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268514
PNG
(US9550775, 38 second compound)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CCC1
Show InChI InChI=1S/C22H30N4O3S/c1-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-2-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)
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n/an/a 5.59n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268524
PNG
(N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...)
Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C20H21ClN4O3S/c1-12-6-15(21)9-16(7-12)28-11-14-8-19-22-23-20(24-29(26,27)17-4-5-17)25(19)10-18(14)13-2-3-13/h6-10,13,17H,2-5,11H2,1H3,(H,23,24)
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n/an/a 6n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268570
PNG
(US9550775, 93 - Second)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CCC1
Show InChI InChI=1S/C22H30N4O3S/c1-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-2-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)
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n/an/a 6n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268524
PNG
(N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...)
Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C20H21ClN4O3S/c1-12-6-15(21)9-16(7-12)28-11-14-8-19-22-23-20(24-29(26,27)17-4-5-17)25(19)10-18(14)13-2-3-13/h6-10,13,17H,2-5,11H2,1H3,(H,23,24)
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n/an/a 6.33n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268505
PNG
(N-(6-cyclopropyl-7-(01S,2S,5S)-6,6-dimethylbicyclo...)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)N4CCC4)n3cc1C1CC1)CC2
Show InChI InChI=1S/C22H31N5O3S/c1-22(2)16-7-6-15(18(22)10-16)13-30-19-11-20-23-24-21(25-31(28,29)26-8-3-9-26)27(20)12-17(19)14-4-5-14/h11-12,14-16,18H,3-10,13H2,1-2H3,(H,24,25)/t15-,16+,18+/m1/s1
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n/an/a 6.75n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268515
PNG
(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Show SMILES Clc1ccc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)cc1Cl
Show InChI InChI=1S/C19H18Cl2N4O3S/c20-16-6-3-13(8-17(16)21)28-10-12-7-18-22-23-19(24-29(26,27)14-4-5-14)25(18)9-15(12)11-1-2-11/h3,6-9,11,14H,1-2,4-5,10H2,(H,23,24)
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n/an/a 6.83n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268550
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C24H32N4O3S/c1-23(4-5-23)32(29,30)27-22-26-25-21-9-20(19(13-28(21)22)18-2-3-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-18H,2-8,10-12,14H2,1H3,(H,26,27)
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n/an/a 7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268553
PNG
(N-(7-(2-((3r,5r,7r)-adamantan-1-yl)ethoxy)-6-cyclo...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-3-4-19)27-23-26-25-22-10-21(20(14-28(22)23)18-1-2-18)31-6-5-24-11-15-7-16(12-24)9-17(8-15)13-24/h10,14-19H,1-9,11-13H2,(H,26,27)
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n/an/a 7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268523
PNG
(N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...)
Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)c1
Show InChI InChI=1S/C18H19ClN4O3S/c1-11-5-14(19)8-15(6-11)26-10-13-7-17-20-21-18(22-27(2,24)25)23(17)9-16(13)12-3-4-12/h5-9,12H,3-4,10H2,1-2H3,(H,21,22)
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n/an/a 7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268505
PNG
(N-(6-cyclopropyl-7-(01S,2S,5S)-6,6-dimethylbicyclo...)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)N4CCC4)n3cc1C1CC1)CC2
Show InChI InChI=1S/C22H31N5O3S/c1-22(2)16-7-6-15(18(22)10-16)13-30-19-11-20-23-24-21(25-31(28,29)26-8-3-9-26)27(20)12-17(19)14-4-5-14/h11-12,14-16,18H,3-10,13H2,1-2H3,(H,24,25)/t15-,16+,18+/m1/s1
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n/an/a 7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268521
PNG
(N-(7-((4-chloro-3-(trifluoromethyl)phenoxy)methyl)...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(c3)C(F)(F)F)c(cn12)C1CC1
Show InChI InChI=1S/C18H16ClF3N4O3S/c1-30(27,28)25-17-24-23-16-6-11(13(8-26(16)17)10-2-3-10)9-29-12-4-5-15(19)14(7-12)18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)
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n/an/a 7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268571
PNG
(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Show SMILES Clc1ccc(COc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)cc1Cl
Show InChI InChI=1S/C19H18Cl2N4O3S/c20-15-6-1-11(7-16(15)21)10-28-17-8-18-22-23-19(24-29(26,27)13-4-5-13)25(18)9-14(17)12-2-3-12/h1,6-9,12-13H,2-5,10H2,(H,23,24)
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n/an/a 7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268520
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)N4CCC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C20H19ClF3N5O4S/c21-14-7-15(9-16(8-14)33-20(22,23)24)32-11-13-6-18-25-26-19(27-34(30,31)28-4-1-5-28)29(18)10-17(13)12-2-3-12/h6-10,12H,1-5,11H2,(H,26,27)
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US Patent
n/an/a 7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268521
PNG
(N-(7-((4-chloro-3-(trifluoromethyl)phenoxy)methyl)...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(c3)C(F)(F)F)c(cn12)C1CC1
Show InChI InChI=1S/C18H16ClF3N4O3S/c1-30(27,28)25-17-24-23-16-6-11(13(8-26(16)17)10-2-3-10)9-29-12-4-5-15(19)14(7-12)18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)
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n/an/a 7.15n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268493
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C24H32N4O3S/c1-23(4-5-23)32(29,30)27-22-26-25-21-9-20(19(13-28(21)22)18-2-3-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-18H,2-8,10-12,14H2,1H3,(H,26,27)
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n/an/a 7.19n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268523
PNG
(N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...)
Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)c1
Show InChI InChI=1S/C18H19ClN4O3S/c1-11-5-14(19)8-15(6-11)26-10-13-7-17-20-21-18(22-27(2,24)25)23(17)9-16(13)12-3-4-12/h5-9,12H,3-4,10H2,1-2H3,(H,21,22)
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n/an/a 7.29n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268520
PNG
(N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...)
Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)N4CCC4)n3cc2C2CC2)c1
Show InChI InChI=1S/C20H19ClF3N5O4S/c21-14-7-15(9-16(8-14)33-20(22,23)24)32-11-13-6-18-25-26-19(27-34(30,31)28-4-1-5-28)29(18)10-17(13)12-2-3-12/h6-10,12H,1-5,11H2,(H,26,27)
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n/an/a 7.33n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268497
PNG
(N-(7-(2-adamantan-1-yl)ethoxy)-6-cyclopropyl-[1,2,...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-3-4-19)27-23-26-25-22-10-21(20(14-28(22)23)18-1-2-18)31-6-5-24-11-15-7-16(12-24)9-17(8-15)13-24/h10,14-19H,1-9,11-13H2,(H,26,27)
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n/an/a 7.35n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268495
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CCC1
Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-2-1-3-19)27-23-26-25-22-9-21(20(13-28(22)23)18-4-5-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-19H,1-8,10-12,14H2,(H,26,27)
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n/an/a 7.54n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268516
PNG
(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(Cl)c3)c(cn12)C1CC1
Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-6-11(13(8-23(16)17)10-2-3-10)9-26-12-4-5-14(18)15(19)7-12/h4-8,10H,2-3,9H2,1H3,(H,21,22)
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n/an/a 7.54n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268492
PNG
(N-[6-cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylme...)
Show SMILES CNS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C21H29N5O3S/c1-22-30(27,28)25-20-24-23-19-7-18(17(11-26(19)20)16-2-3-16)29-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16,22H,2-6,8-10,12H2,1H3,(H,24,25)
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n/an/a 7.78n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268516
PNG
(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(Cl)c3)c(cn12)C1CC1
Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-6-11(13(8-23(16)17)10-2-3-10)9-26-12-4-5-14(18)15(19)7-12/h4-8,10H,2-3,9H2,1H3,(H,21,22)
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n/an/a 8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268588
PNG
(N-(6-cyclopropyl-7-((1-(3,5-dichlorobenzyl)-4-meth...)
Show SMILES CC1(COc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)CCN(Cc2cc(Cl)cc(Cl)c2)CC1
Show InChI InChI=1S/C26H31Cl2N5O3S/c1-26(6-8-32(9-7-26)14-17-10-19(27)12-20(28)11-17)16-36-23-13-24-29-30-25(31-37(34,35)21-4-5-21)33(24)15-22(23)18-2-3-18/h10-13,15,18,21H,2-9,14,16H2,1H3,(H,30,31)
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n/an/a 8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268535
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)N1CCCC1
Show InChI InChI=1S/C24H33N5O3S/c30-33(31,28-5-1-2-6-28)27-23-26-25-22-10-21(20(14-29(22)23)19-3-4-19)32-15-24-11-16-7-17(12-24)9-18(8-16)13-24/h10,14,16-19H,1-9,11-13,15H2,(H,26,27)
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n/an/a 8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268549
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES CNS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C21H29N5O3S/c1-22-30(27,28)25-20-24-23-19-7-18(17(11-26(19)20)16-2-3-16)29-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16,22H,2-6,8-10,12H2,1H3,(H,24,25)
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n/an/a 8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268591
PNG
(N-(6-cyclopropyl-7-((6-methylspiro[2.5]octan-6-yl)...)
Show SMILES CC1(COc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)CCC2(CC2)CC1
Show InChI InChI=1S/C22H30N4O3S/c1-21(6-8-22(9-7-21)10-11-22)14-29-18-12-19-23-24-20(25-30(27,28)16-4-5-16)26(19)13-17(18)15-2-3-15/h12-13,15-16H,2-11,14H2,1H3,(H,24,25)
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n/an/a 8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268428
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)N1CCCC1
Show InChI InChI=1S/C24H33N5O3S/c30-33(31,28-5-1-2-6-28)27-23-26-25-22-10-21(20(14-29(22)23)19-3-4-19)32-15-24-11-16-7-17(12-24)9-18(8-16)13-24/h10,14,16-19H,1-9,11-13,15H2,(H,26,27)
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n/an/a 8.40n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268496
PNG
(N-(7-(2-(adamantan-2-yl)ethoxy)-6-cyclopropyl-[1,2...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C22H30N4O3S/c1-30(27,28)25-21-24-23-20-9-19(18(13-26(20)21)17-2-3-17)29-5-4-22-10-14-6-15(11-22)8-16(7-14)12-22/h9,13-17H,2-8,10-12H2,1H3,(H,24,25)
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n/an/a 8.51n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268552
PNG
(N-(7-(2-43r,5r,7r)-adamantan-1-yl)ethoxy)-6-cyclop...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C22H30N4O3S/c1-30(27,28)25-21-24-23-20-9-19(18(13-26(20)21)17-2-3-17)29-5-4-22-10-14-6-15(11-22)8-16(7-14)12-22/h9,13-17H,2-8,10-12H2,1H3,(H,24,25)
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n/an/a 9n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268604
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)N1CCC1
Show InChI InChI=1S/C23H31N5O3S/c29-32(30,27-4-1-5-27)26-22-25-24-21-9-20(19(13-28(21)22)18-2-3-18)31-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h9,13,15-18H,1-8,10-12,14H2,(H,25,26)
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n/an/a 9n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268522
PNG
(N-(7-((4-chloro-3-(trifluoromethyl)phenoxy)methyl)...)
Show SMILES FC(F)(F)c1cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)ccc1Cl
Show InChI InChI=1S/C20H18ClF3N4O3S/c21-17-6-3-13(8-16(17)20(22,23)24)31-10-12-7-18-25-26-19(27-32(29,30)14-4-5-14)28(18)9-15(12)11-1-2-11/h3,6-9,11,14H,1-2,4-5,10H2,(H,26,27)
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n/an/a 10.8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268522
PNG
(N-(7-((4-chloro-3-(trifluoromethyl)phenoxy)methyl)...)
Show SMILES FC(F)(F)c1cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)ccc1Cl
Show InChI InChI=1S/C20H18ClF3N4O3S/c21-17-6-3-13(8-16(17)20(22,23)24)31-10-12-7-18-25-26-19(27-32(29,30)14-4-5-14)28(18)9-15(12)11-1-2-11/h3,6-9,11,14H,1-2,4-5,10H2,(H,26,27)
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n/an/a 11n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268502
PNG
(N-(6-cyclopropyl-7-(((2s,3aR,4S,7R,7aS)-octahydro-...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1)N1CCC1
Show InChI InChI=1S/C23H31N5O3S/c29-32(30,27-6-1-7-27)26-23-25-24-22-11-21(20(12-28(22)23)15-2-3-15)31-13-14-8-18-16-4-5-17(10-16)19(18)9-14/h11-12,14-19H,1-10,13H2,(H,25,26)
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n/an/a 11n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268502
PNG
(N-(6-cyclopropyl-7-(((2s,3aR,4S,7R,7aS)-octahydro-...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1)N1CCC1
Show InChI InChI=1S/C23H31N5O3S/c29-32(30,27-6-1-7-27)26-23-25-24-22-11-21(20(12-28(22)23)15-2-3-15)31-13-14-8-18-16-4-5-17(10-16)19(18)9-14/h11-12,14-19H,1-10,13H2,(H,25,26)
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n/an/a 11.5n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268598
PNG
((S)—N-(6-cyclopropyl-7-(0-(1-(3,5-dichlorophe...)
Show SMILES C[C@H](N1CCC(COc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C26H31Cl2N5O3S/c1-16(19-10-20(27)12-21(28)11-19)32-8-6-17(7-9-32)15-36-24-13-25-29-30-26(31-37(34,35)22-4-5-22)33(25)14-23(24)18-2-3-18/h10-14,16-18,22H,2-9,15H2,1H3,(H,30,31)/t16-/m0/s1
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n/an/a 12n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268587
PNG
(N-(6-cyclopropyl-7-((1-(3,5-dichlorobenzyl)-4-meth...)
Show SMILES CC1(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CCN(Cc2cc(Cl)cc(Cl)c2)CC1
Show InChI InChI=1S/C24H29Cl2N5O3S/c1-24(5-7-30(8-6-24)13-16-9-18(25)11-19(26)10-16)15-34-21-12-22-27-28-23(29-35(2,32)33)31(22)14-20(21)17-3-4-17/h9-12,14,17H,3-8,13,15H2,1-2H3,(H,28,29)
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n/an/a 12n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268429
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-ethyl-[1...)
Show SMILES CCc1cn2c(NS(=O)(=O)C3CC3)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N4O3S/c1-2-17-12-26-20(23-24-21(26)25-30(27,28)18-3-4-18)8-19(17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-16,18H,2-7,9-11,13H2,1H3,(H,24,25)
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n/an/a 12.5n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268594
PNG
((S)—N-(6-cyclopropyl-7-((1-(1-(3,5-dichloroph...)
Show SMILES C[C@H](N1CCC(C)(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C25H31Cl2N5O3S/c1-16(18-10-19(26)12-20(27)11-18)31-8-6-25(2,7-9-31)15-35-22-13-23-28-29-24(30-36(3,33)34)32(23)14-21(22)17-4-5-17/h10-14,16-17H,4-9,15H2,1-3H3,(H,29,30)/t16-/m0/s1
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n/an/a 13n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268536
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-ethyl-[1...)
Show SMILES CCc1cn2c(NS(=O)(=O)C3CC3)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30N4O3S/c1-2-17-12-26-20(23-24-21(26)25-30(27,28)18-3-4-18)8-19(17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-16,18H,2-7,9-11,13H2,1H3,(H,24,25)
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n/an/a 13n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268473
PNG
(N-(6-cyclopropyl-7-((1-methylcyclohexyl)methoxy)-[...)
Show SMILES CC1(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CCCCC1
Show InChI InChI=1S/C18H26N4O3S/c1-18(8-4-3-5-9-18)12-25-15-10-16-19-20-17(21-26(2,23)24)22(16)11-14(15)13-6-7-13/h10-11,13H,3-9,12H2,1-2H3,(H,20,21)
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n/an/a 14n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268473
PNG
(N-(6-cyclopropyl-7-((1-methylcyclohexyl)methoxy)-[...)
Show SMILES CC1(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CCCCC1
Show InChI InChI=1S/C18H26N4O3S/c1-18(8-4-3-5-9-18)12-25-15-10-16-19-20-17(21-26(2,23)24)22(16)11-14(15)13-6-7-13/h10-11,13H,3-9,12H2,1-2H3,(H,20,21)
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n/an/a 14n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268595
PNG
((R)—N-(6-cyclopropyl-7-(0-(1-(3,5-dichlorophe...)
Show SMILES C[C@@H](N1CCC(C)(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C25H31Cl2N5O3S/c1-16(18-10-19(26)12-20(27)11-18)31-8-6-25(2,7-9-31)15-35-22-13-23-28-29-24(30-36(3,33)34)32(23)14-21(22)17-4-5-17/h10-14,16-17H,4-9,15H2,1-3H3,(H,29,30)/t16-/m1/s1
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n/an/a 14n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268593
PNG
(N-(7-((1-benzhydryl-4-methylpiperidin-4-yl)methoxy...)
Show SMILES CC1(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CCN(CC1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H35N5O3S/c1-30(15-17-34(18-16-30)28(23-9-5-3-6-10-23)24-11-7-4-8-12-24)21-38-26-19-27-31-32-29(33-39(2,36)37)35(27)20-25(26)22-13-14-22/h3-12,19-20,22,28H,13-18,21H2,1-2H3,(H,32,33)
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n/an/a 16n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268597
PNG
((S)—N-(6-cyclopropyl-7-((1-(1-(3,5-dichloroph...)
Show SMILES C[C@H](N1CCC(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C24H29Cl2N5O3S/c1-15(18-9-19(25)11-20(26)10-18)30-7-5-16(6-8-30)14-34-22-12-23-27-28-24(29-35(2,32)33)31(23)13-21(22)17-3-4-17/h9-13,15-17H,3-8,14H2,1-2H3,(H,28,29)/t15-/m0/s1
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n/an/a 17n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268600
PNG
(N-(7-(01R,3S,5S)-8-benzhydryl-8-azabicyclo[3.2.1]o...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OC[C@H]3C[C@@H]4CC[C@H](C3)N4C(c3ccccc3)c3ccccc3)c(cn12)C1CC1
Show InChI InChI=1S/C31H35N5O3S/c1-40(37,38)34-31-33-32-29-18-28(27(19-35(29)31)22-12-13-22)39-20-21-16-25-14-15-26(17-21)36(25)30(23-8-4-2-5-9-23)24-10-6-3-7-11-24/h2-11,18-19,21-22,25-26,30H,12-17,20H2,1H3,(H,33,34)/t21-,25-,26+
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n/an/a 17n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268564
PNG
(N-(6-cyclopropyl-7-(trans-4-methylcyclohexyl)metho...)
Show SMILES C[C@H]1CC[C@H](COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CC1
Show InChI InChI=1S/C18H26N4O3S/c1-12-3-5-13(6-4-12)11-25-16-9-17-19-20-18(21-26(2,23)24)22(17)10-15(16)14-7-8-14/h9-10,12-14H,3-8,11H2,1-2H3,(H,20,21)/t12-,13-
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n/an/a 18n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268508
PNG
(N-(6-cyclopropyl-7-(trans-4-methylcyclohexyl)metho...)
Show SMILES C[C@H]1CC[C@H](COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CC1
Show InChI InChI=1S/C18H26N4O3S/c1-12-3-5-13(6-4-12)11-25-16-9-17-19-20-18(21-26(2,23)24)22(17)10-15(16)14-7-8-14/h9-10,12-14H,3-8,11H2,1-2H3,(H,20,21)/t12-,13-
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n/an/a 18.4n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268511
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]...)
Show SMILES FC(F)S(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C21H26F2N4O3S/c22-19(23)31(28,29)26-20-25-24-18-6-17(16(10-27(18)20)15-1-2-15)30-11-21-7-12-3-13(8-21)5-14(4-12)9-21/h6,10,12-15,19H,1-5,7-9,11H2,(H,25,26)
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n/an/a 18.7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268517
PNG
(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Show SMILES Clc1ccc(OCc2cc3nnc(NS(=O)(=O)N4CCC4)n3cc2C2CC2)cc1Cl
Show InChI InChI=1S/C19H19Cl2N5O3S/c20-16-5-4-14(9-17(16)21)29-11-13-8-18-22-23-19(24-30(27,28)25-6-1-7-25)26(18)10-15(13)12-2-3-12/h4-5,8-10,12H,1-3,6-7,11H2,(H,23,24)
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n/an/a 18.9n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268517
PNG
(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Show SMILES Clc1ccc(OCc2cc3nnc(NS(=O)(=O)N4CCC4)n3cc2C2CC2)cc1Cl
Show InChI InChI=1S/C19H19Cl2N5O3S/c20-16-5-4-14(9-17(16)21)29-11-13-8-18-22-23-19(24-30(27,28)25-6-1-7-25)26(18)10-15(13)12-2-3-12/h4-5,8-10,12H,1-3,6-7,11H2,(H,23,24)
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n/an/a 19n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268511
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-cyclopropyl-[1,2,4]...)
Show SMILES FC(F)S(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1
Show InChI InChI=1S/C21H26F2N4O3S/c22-19(23)31(28,29)26-20-25-24-18-6-17(16(10-27(18)20)15-1-2-15)30-11-21-7-12-3-13(8-21)5-14(4-12)9-21/h6,10,12-15,19H,1-5,7-9,11H2,(H,25,26)
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n/an/a 19n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268592
PNG
(N-(6-cyclopropyl-7-((4-fluorobicyclo[2.2.2]octan-1...)
Show SMILES FC12CCC(COc3cc4nnc(NS(=O)(=O)C5CC5)n4cc3C3CC3)(CC1)CC2
Show InChI InChI=1S/C21H27FN4O3S/c22-21-8-5-20(6-9-21,7-10-21)13-29-17-11-18-23-24-19(25-30(27,28)15-3-4-15)26(18)12-16(17)14-1-2-14/h11-12,14-15H,1-10,13H2,(H,24,25)
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n/an/a 21n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268489
PNG
(N-(6-cyclopropyl-7-(spiro[2.5]octan-6-ylmethoxy)-[...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CCC4(CC4)CC3)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C21H28N4O3S/c26-29(27,16-3-4-16)24-20-23-22-19-11-18(17(12-25(19)20)15-1-2-15)28-13-14-5-7-21(8-6-14)9-10-21/h11-12,14-16H,1-10,13H2,(H,23,24)
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n/an/a 21.7n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268489
PNG
(N-(6-cyclopropyl-7-(spiro[2.5]octan-6-ylmethoxy)-[...)
Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CCC4(CC4)CC3)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C21H28N4O3S/c26-29(27,16-3-4-16)24-20-23-22-19-11-18(17(12-25(19)20)15-1-2-15)28-13-14-5-7-21(8-6-14)9-10-21/h11-12,14-16H,1-10,13H2,(H,23,24)
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n/an/a 22n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268472
PNG
(N-(6-cyclopropyl-7-(((trans)-4-(trifluoromethyl)cy...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OC[C@H]3CC[C@@H](CC3)C(F)(F)F)c(cn12)C1CC1
Show InChI InChI=1S/C18H23F3N4O3S/c1-29(26,27)24-17-23-22-16-8-15(14(9-25(16)17)12-4-5-12)28-10-11-2-6-13(7-3-11)18(19,20)21/h8-9,11-13H,2-7,10H2,1H3,(H,23,24)/t11-,13-
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n/an/a 22.6n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268596
PNG
((R)—N-(6-cyclopropyl-7-((1-(1-(3,5-dichloroph...)
Show SMILES C[C@@H](N1CCC(COc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C24H29Cl2N5O3S/c1-15(18-9-19(25)11-20(26)10-18)30-7-5-16(6-8-30)14-34-22-12-23-27-28-24(29-35(2,32)33)31(23)13-21(22)17-3-4-17/h9-13,15-17H,3-8,14H2,1-2H3,(H,28,29)/t15-/m1/s1
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n/an/a 23n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268544
PNG
(N-(6-cyclopropyl-7-(((trans)-4-(trifluoromethyl)cy...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OC[C@H]3CC[C@@H](CC3)C(F)(F)F)c(cn12)C1CC1
Show InChI InChI=1S/C18H23F3N4O3S/c1-29(26,27)24-17-23-22-16-8-15(14(9-25(16)17)12-4-5-12)28-10-11-2-6-13(7-3-11)18(19,20)21/h8-9,11-13H,2-7,10H2,1H3,(H,23,24)/t11-,13-
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n/an/a 23n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268422
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-bromo-[1...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(Br)cn12
Show InChI InChI=1S/C18H23BrN4O3S/c1-27(24,25)22-17-21-20-16-5-15(14(19)9-23(16)17)26-10-18-6-11-2-12(7-18)4-13(3-11)8-18/h5,9,11-13H,2-4,6-8,10H2,1H3,(H,21,22)
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n/an/a 27.8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268533
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-bromo-[1...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(Br)cn12
Show InChI InChI=1S/C18H23BrN4O3S/c1-27(24,25)22-17-21-20-16-5-15(14(19)9-23(16)17)26-10-18-6-11-2-12(7-18)4-13(3-11)8-18/h5,9,11-13H,2-4,6-8,10H2,1H3,(H,21,22)
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n/an/a 28n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268603
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Show SMILES CCc1cn2c(NS(=O)(=O)N3CCC3)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H31N5O3S/c1-2-18-13-27-20(23-24-21(27)25-31(28,29)26-4-3-5-26)9-19(18)30-14-22-10-15-6-16(11-22)8-17(7-15)12-22/h9,13,15-17H,2-8,10-12,14H2,1H3,(H,24,25)
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n/an/a 31n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268590
PNG
((R)—N-(7-((1-(2-chloro-4-fluorobenzyl)piperid...)
Show SMILES Fc1ccc(CN2CCC[C@H](C2)Oc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c(Cl)c1
Show InChI InChI=1S/C24H27ClFN5O3S/c25-21-10-17(26)6-5-16(21)12-30-9-1-2-18(13-30)34-22-11-23-27-28-24(29-35(32,33)19-7-8-19)31(23)14-20(22)15-3-4-15/h5-6,10-11,14-15,18-19H,1-4,7-9,12-13H2,(H,28,29)/t18-/m1/s1
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n/an/a 34n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268465
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-isopropyl-[1,2,4]-t...)
Show SMILES CC(C)c1cn2c(N)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H28N4O/c1-12(2)16-10-24-18(22-23-19(24)21)6-17(16)25-11-20-7-13-3-14(8-20)5-15(4-13)9-20/h6,10,12-15H,3-5,7-9,11H2,1-2H3,(H2,21,23)
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n/an/a 39.5n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268465
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-isopropyl-[1,2,4]-t...)
Show SMILES CC(C)c1cn2c(N)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H28N4O/c1-12(2)16-10-24-18(22-23-19(24)21)6-17(16)25-11-20-7-13-3-14(8-20)5-15(4-13)9-20/h6,10,12-15H,3-5,7-9,11H2,1-2H3,(H2,21,23)
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n/an/a 40n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268602
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Show SMILES CCc1cn2c(NS(C)(=O)=O)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H28N4O3S/c1-3-16-11-24-18(21-22-19(24)23-28(2,25)26)7-17(16)27-12-20-8-13-4-14(9-20)6-15(5-13)10-20/h7,11,13-15H,3-6,8-10,12H2,1-2H3,(H,22,23)
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n/an/a 41n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268605
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-vinyl-[1,2,4]triazo...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C=C)cn12
Show InChI InChI=1S/C20H26N4O3S/c1-3-16-11-24-18(21-22-19(24)23-28(2,25)26)7-17(16)27-12-20-8-13-4-14(9-20)6-15(5-13)10-20/h3,7,11,13-15H,1,4-6,8-10,12H2,2H3,(H,22,23)
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n/an/a 45n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268512
PNG
(N-(6-cyclopropyl-7-((1-(trifluoromethyl)cyclopenty...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3(CCCC3)C(F)(F)F)c(cn12)C1CC1
Show InChI InChI=1S/C17H21F3N4O3S/c1-28(25,26)23-15-22-21-14-8-13(12(9-24(14)15)11-4-5-11)27-10-16(17(18,19)20)6-2-3-7-16/h8-9,11H,2-7,10H2,1H3,(H,22,23)
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n/an/a 45n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268512
PNG
(N-(6-cyclopropyl-7-((1-(trifluoromethyl)cyclopenty...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3(CCCC3)C(F)(F)F)c(cn12)C1CC1
Show InChI InChI=1S/C17H21F3N4O3S/c1-28(25,26)23-15-22-21-14-8-13(12(9-24(14)15)11-4-5-11)27-10-16(17(18,19)20)6-2-3-7-16/h8-9,11H,2-7,10H2,1H3,(H,22,23)
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n/an/a 45.2n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268530
PNG
(N-(7-(cyclohexylmethoxy)-6-cyclopropyl-[1,2,4]tria...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CCCCC3)c(cn12)C1CC1
Show InChI InChI=1S/C17H24N4O3S/c1-25(22,23)20-17-19-18-16-9-15(14(10-21(16)17)13-7-8-13)24-11-12-5-3-2-4-6-12/h9-10,12-13H,2-8,11H2,1H3,(H,19,20)
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n/an/a 51n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268442
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-(prop-1-en-2-yl)-[1...)
Show SMILES CC(=C)c1cn2c(NS(C)(=O)=O)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H28N4O3S/c1-13(2)17-11-25-19(22-23-20(25)24-29(3,26)27)7-18(17)28-12-21-8-14-4-15(9-21)6-16(5-14)10-21/h7,11,14-16H,1,4-6,8-10,12H2,2-3H3,(H,23,24)
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n/an/a 51n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268510
PNG
(N-(6-cyclopropyl-7-(spiro[5.5]undecan-3-yloxy)-[1,...)
Show SMILES O=S(=O)(Nc1nnc2cc(OC3CCC4(CCCCC4)CC3)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C23H32N4O3S/c28-31(29,18-6-7-18)26-22-25-24-21-14-20(19(15-27(21)22)16-4-5-16)30-17-8-12-23(13-9-17)10-2-1-3-11-23/h14-18H,1-13H2,(H,25,26)
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n/an/a 51n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268530
PNG
(N-(7-(cyclohexylmethoxy)-6-cyclopropyl-[1,2,4]tria...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CCCCC3)c(cn12)C1CC1
Show InChI InChI=1S/C17H24N4O3S/c1-25(22,23)20-17-19-18-16-9-15(14(10-21(16)17)13-7-8-13)24-11-12-5-3-2-4-6-12/h9-10,12-13H,2-8,11H2,1H3,(H,19,20)
PDB

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n/an/a 51n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268442
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-(prop-1-en-2-yl)-[1...)
Show SMILES CC(=C)c1cn2c(NS(C)(=O)=O)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H28N4O3S/c1-13(2)17-11-25-19(22-23-20(25)24-29(3,26)27)7-18(17)28-12-21-8-14-4-15(9-21)6-16(5-14)10-21/h7,11,14-16H,1,4-6,8-10,12H2,2-3H3,(H,23,24)
PDB

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n/an/a 51.2n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268510
PNG
(N-(6-cyclopropyl-7-(spiro[5.5]undecan-3-yloxy)-[1,...)
Show SMILES O=S(=O)(Nc1nnc2cc(OC3CCC4(CCCCC4)CC3)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C23H32N4O3S/c28-31(29,18-6-7-18)26-22-25-24-21-14-20(19(15-27(21)22)16-4-5-16)30-17-8-12-23(13-9-17)10-2-1-3-11-23/h14-18H,1-13H2,(H,25,26)
PDB

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n/an/a 51.3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268431
PNG
(N-(7-((1-methylcyclohexyl)methoxy)-6-vinyl-[1,2,4]...)
Show SMILES CC1(COc2cc3nnc(NS(C)(=O)=O)n3cc2C=C)CCCCC1
Show InChI InChI=1S/C17H24N4O3S/c1-4-13-11-21-15(18-19-16(21)20-25(3,22)23)10-14(13)24-12-17(2)8-6-5-7-9-17/h4,10-11H,1,5-9,12H2,2-3H3,(H,19,20)
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n/an/a 65n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268431
PNG
(N-(7-((1-methylcyclohexyl)methoxy)-6-vinyl-[1,2,4]...)
Show SMILES CC1(COc2cc3nnc(NS(C)(=O)=O)n3cc2C=C)CCCCC1
Show InChI InChI=1S/C17H24N4O3S/c1-4-13-11-21-15(18-19-16(21)20-25(3,22)23)10-14(13)24-12-17(2)8-6-5-7-9-17/h4,10-11H,1,5-9,12H2,2-3H3,(H,19,20)
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n/an/a 65.3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268499
PNG
(N-(7-(adamantan-2-yloxy)-6-cyclopropyl-[1,2,4]tria...)
Show SMILES O=S(=O)(Nc1nnc2cc(OC3C4CC5CC(C4)CC3C5)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C22H28N4O3S/c27-30(28,17-3-4-17)25-22-24-23-20-10-19(18(11-26(20)22)14-1-2-14)29-21-15-6-12-5-13(8-15)9-16(21)7-12/h10-17,21H,1-9H2,(H,24,25)
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n/an/a 65.8n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268499
PNG
(N-(7-(adamantan-2-yloxy)-6-cyclopropyl-[1,2,4]tria...)
Show SMILES O=S(=O)(Nc1nnc2cc(OC3C4CC5CC(C4)CC3C5)c(cn12)C1CC1)C1CC1
Show InChI InChI=1S/C22H28N4O3S/c27-30(28,17-3-4-17)25-22-24-23-20-10-19(18(11-26(20)22)14-1-2-14)29-21-15-6-12-5-13(8-15)9-16(21)7-12/h10-17,21H,1-9H2,(H,24,25)
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n/an/a 66n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268529
PNG
(N-(6-cyclopropyl-7-((4,4-difluoro-1-methylcyclohex...)
Show SMILES CC1(COc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)CCC(F)(F)CC1
Show InChI InChI=1S/C20H26F2N4O3S/c1-19(6-8-20(21,22)9-7-19)12-29-16-10-17-23-24-18(25-30(27,28)14-4-5-14)26(17)11-15(16)13-2-3-13/h10-11,13-14H,2-9,12H2,1H3,(H,24,25)
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n/an/a 67n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268529
PNG
(N-(6-cyclopropyl-7-((4,4-difluoro-1-methylcyclohex...)
Show SMILES CC1(COc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)CCC(F)(F)CC1
Show InChI InChI=1S/C20H26F2N4O3S/c1-19(6-8-20(21,22)9-7-19)12-29-16-10-17-23-24-18(25-30(27,28)14-4-5-14)26(17)11-15(16)13-2-3-13/h10-11,13-14H,2-9,12H2,1H3,(H,24,25)
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n/an/a 67.4n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268507
PNG
(N-(6-bromo-7-(trans-4-methylcyclohexyl)methoxy)-[1...)
Show SMILES C[C@H]1CC[C@H](COc2cc3nnc(NS(C)(=O)=O)n3cc2Br)CC1
Show InChI InChI=1S/C15H21BrN4O3S/c1-10-3-5-11(6-4-10)9-23-13-7-14-17-18-15(19-24(2,21)22)20(14)8-12(13)16/h7-8,10-11H,3-6,9H2,1-2H3,(H,18,19)/t10-,11-
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n/an/a 86.6n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268563
PNG
(N-(6-bromo-7-(trans-4-methylcyclohexyl)methoxy)-[1...)
Show SMILES C[C@H]1CC[C@H](COc2cc3nnc(NS(C)(=O)=O)n3cc2Br)CC1
Show InChI InChI=1S/C15H21BrN4O3S/c1-10-3-5-11(6-4-10)9-23-13-7-14-17-18-15(19-24(2,21)22)20(14)8-12(13)16/h7-8,10-11H,3-6,9H2,1-2H3,(H,18,19)/t10-,11-
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n/an/a 87n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268430
PNG
(N-(6-bromo-7-(cyclohexylmethoxy)-[1,2,4]triazolo[4...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CCCCC3)c(Br)cn12
Show InChI InChI=1S/C14H19BrN4O3S/c1-23(20,21)18-14-17-16-13-7-12(11(15)8-19(13)14)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,17,18)
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n/an/a 90n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268430
PNG
(N-(6-bromo-7-(cyclohexylmethoxy)-[1,2,4]triazolo[4...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CCCCC3)c(Br)cn12
Show InChI InChI=1S/C14H19BrN4O3S/c1-23(20,21)18-14-17-16-13-7-12(11(15)8-19(13)14)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,17,18)
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n/an/a 90.3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268565
PNG
(N-(6-(2-methoxypyridin-3-yl)-7-(trans-4-methylcycl...)
Show SMILES COc1ncccc1-c1cn2c(NS(C)(=O)=O)nnc2cc1OC[C@H]1CC[C@H](C)CC1
Show InChI InChI=1S/C21H27N5O4S/c1-14-6-8-15(9-7-14)13-30-18-11-19-23-24-21(25-31(3,27)28)26(19)12-17(18)16-5-4-10-22-20(16)29-2/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,24,25)/t14-,15-
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n/an/a 130n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268589
PNG
((R)—N-(7-((1-(2-chloro-4-fluorobenzyl)piperid...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(O[C@@H]3CCCN(Cc4ccc(F)cc4Cl)C3)c(cn12)C1CC1
Show InChI InChI=1S/C22H25ClFN5O3S/c1-33(30,31)27-22-26-25-21-10-20(18(13-29(21)22)14-4-5-14)32-17-3-2-8-28(12-17)11-15-6-7-16(24)9-19(15)23/h6-7,9-10,13-14,17H,2-5,8,11-12H2,1H3,(H,26,27)/t17-/m1/s1
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n/an/a 130n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268509
PNG
(N-(6-(2-methoxypyridin-3-yl)-7-(trans-4-methylcycl...)
Show SMILES COc1ncccc1-c1cn2c(NS(C)(=O)=O)nnc2cc1OC[C@H]1CC[C@H](C)CC1
Show InChI InChI=1S/C21H27N5O4S/c1-14-6-8-15(9-7-14)13-30-18-11-19-23-24-21(25-31(3,27)28)26(19)12-17(18)16-5-4-10-22-20(16)29-2/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,24,25)/t14-,15-
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n/an/a 133n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268480
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-ethyl-[1...)
Show SMILES CCc1cn2c(NS(=O)(=O)N3CC(F)C3)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30FN5O3S/c1-2-17-10-28-20(24-25-21(28)26-32(29,30)27-11-18(23)12-27)6-19(17)31-13-22-7-14-3-15(8-22)5-16(4-14)9-22/h6,10,14-16,18H,2-5,7-9,11-13H2,1H3,(H,25,26)
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n/an/a 138n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268546
PNG
(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-ethyl-[1...)
Show SMILES CCc1cn2c(NS(=O)(=O)N3CC(F)C3)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H30FN5O3S/c1-2-17-10-28-20(24-25-21(28)26-32(29,30)27-11-18(23)12-27)6-19(17)31-13-22-7-14-3-15(8-22)5-16(4-14)9-22/h6,10,14-16,18H,2-5,7-9,11-13H2,1H3,(H,25,26)
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n/an/a 140n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268443
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-bromo-[1,2,4]triazo...)
Show SMILES Brc1cn2c(NS(=O)(=O)N3CCOCC3)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H28BrN5O4S/c22-17-12-27-19(23-24-20(27)25-32(28,29)26-1-3-30-4-2-26)8-18(17)31-13-21-9-14-5-15(10-21)7-16(6-14)11-21/h8,12,14-16H,1-7,9-11,13H2,(H,24,25)
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n/an/a 206n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268443
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-bromo-[1,2,4]triazo...)
Show SMILES Brc1cn2c(NS(=O)(=O)N3CCOCC3)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C21H28BrN5O4S/c22-17-12-27-19(23-24-20(27)25-32(28,29)26-1-3-30-4-2-26)8-18(17)31-13-21-9-14-5-15(10-21)7-16(6-14)11-21/h8,12,14-16H,1-7,9-11,13H2,(H,24,25)
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n/an/a 210n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268506
PNG
(N-(6-cyclopropyl-7-(((1S,2R,4R)-1,7,7-trimethylbic...)
Show SMILES CC1(C)[C@H]2CC[C@@]1(C)[C@@H](C2)Oc1cc2nnc(NS(C)(=O)=O)n2cc1C1CC1
Show InChI InChI=1S/C20H28N4O3S/c1-19(2)13-7-8-20(19,3)16(9-13)27-15-10-17-21-22-18(23-28(4,25)26)24(17)11-14(15)12-5-6-12/h10-13,16H,5-9H2,1-4H3,(H,22,23)/t13-,16+,20-/m0/s1
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n/an/a 260n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268506
PNG
(N-(6-cyclopropyl-7-(((1S,2R,4R)-1,7,7-trimethylbic...)
Show SMILES CC1(C)[C@H]2CC[C@@]1(C)[C@@H](C2)Oc1cc2nnc(NS(C)(=O)=O)n2cc1C1CC1
Show InChI InChI=1S/C20H28N4O3S/c1-19(2)13-7-8-20(19,3)16(9-13)27-15-10-17-21-22-18(23-28(4,25)26)24(17)11-14(15)12-5-6-12/h10-13,16H,5-9H2,1-4H3,(H,22,23)/t13-,16+,20-/m0/s1
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n/an/a 260n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268601
PNG
(N-(6-cyclopropyl-7-((4-(3,5-dichlorophenoxy)piperi...)
Show SMILES Clc1cc(Cl)cc(OC2CCN(Cc3cc4nnc(NS(=O)(=O)C5CC5)n4cc3C3CC3)CC2)c1
Show InChI InChI=1S/C24H27Cl2N5O3S/c25-17-10-18(26)12-20(11-17)34-19-5-7-30(8-6-19)13-16-9-23-27-28-24(29-35(32,33)21-3-4-21)31(23)14-22(16)15-1-2-15/h9-12,14-15,19,21H,1-8,13H2,(H,28,29)
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n/an/a 320n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268554
PNG
(N-(7-((1r,3r,5r,7r)-adamantan-2-yloxy)-6-cycloprop...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OC3C4CC5CC(C4)CC3C5)c(cn12)C1CC1
Show InChI InChI=1S/C20H26N4O3S/c1-28(25,26)23-20-22-21-18-9-17(16(10-24(18)20)13-2-3-13)27-19-14-5-11-4-12(7-14)8-15(19)6-11/h9-15,19H,2-8H2,1H3,(H,22,23)
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n/an/a 340n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268498
PNG
(N-(7-adamantan-2-yloxy)-6-cyclopropyl-[1,2,4]triaz...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OC3C4CC5CC(C4)CC3C5)c(cn12)C1CC1
Show InChI InChI=1S/C20H26N4O3S/c1-28(25,26)23-20-22-21-18-9-17(16(10-24(18)20)13-2-3-13)27-19-14-5-11-4-12(7-14)8-15(19)6-11/h9-15,19H,2-8H2,1H3,(H,22,23)
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US Patent
n/an/a 344n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268470
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-(cyclopent-1-en-1-y...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1=CCCC1
Show InChI InChI=1S/C23H30N4O3S/c1-31(28,29)26-22-25-24-21-9-20(19(13-27(21)22)18-4-2-3-5-18)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h4,9,13,15-17H,2-3,5-8,10-12,14H2,1H3,(H,25,26)
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n/an/a 540n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268470
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-(cyclopent-1-en-1-y...)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1=CCCC1
Show InChI InChI=1S/C23H30N4O3S/c1-31(28,29)26-22-25-24-21-9-20(19(13-27(21)22)18-4-2-3-5-18)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h4,9,13,15-17H,2-3,5-8,10-12,14H2,1H3,(H,25,26)
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n/an/a 544n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268464
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-(2-methoxypyridin-3...)
Show SMILES COc1ncccc1-c1cn2c(NS(C)(=O)=O)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H29N5O4S/c1-32-22-18(4-3-5-25-22)19-13-29-21(26-27-23(29)28-34(2,30)31)9-20(19)33-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h3-5,9,13,15-17H,6-8,10-12,14H2,1-2H3,(H,27,28)
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n/an/a 637n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268464
PNG
(N-(7-(adamantan-1-ylmethoxy)-6-(2-methoxypyridin-3...)
Show SMILES COc1ncccc1-c1cn2c(NS(C)(=O)=O)nnc2cc1OCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H29N5O4S/c1-32-22-18(4-3-5-25-22)19-13-29-21(26-27-23(29)28-34(2,30)31)9-20(19)33-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h3-5,9,13,15-17H,6-8,10-12,14H2,1-2H3,(H,27,28)
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n/an/a 640n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268569
PNG
(US9550775, 93 - First)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)ccn12
Show InChI InChI=1S/C18H24N4O3S/c1-26(23,24)21-17-20-19-16-7-15(2-3-22(16)17)25-11-18-8-12-4-13(9-18)6-14(5-12)10-18/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,20,21)
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n/an/a 960n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM268513
PNG
(US9550775, 38 first compound)
Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)ccn12
Show InChI InChI=1S/C18H24N4O3S/c1-26(23,24)21-17-20-19-16-7-15(2-3-22(16)17)25-11-18-8-12-4-13(9-18)6-14(5-12)10-18/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,20,21)
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n/an/a 961n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9550775 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%