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Patent code US9550781

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
b-raf


()
BDBM50165873
PNG
(CHEMBL3800014 | US9550781, 19)
Show SMILES Fc1ccc(NS(=O)(=O)CC(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C18H12F5N7O2S/c19-10-3-4-11(30-33(31,32)6-18(21,22)23)12(20)14(10)29-16-9(2-1-5-24-16)13-15-17(27-7-25-13)28-8-26-15/h1-5,7-8,30H,6H2,(H,24,29)(H,25,26,27,28)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205021
PNG
(US9550781, 18 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES Fc1ccc(NS(=O)(=O)CCC(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C19H14F5N7O2S/c20-11-3-4-12(31-34(32,33)7-5-19(22,23)24)13(21)15(11)30-17-10(2-1-6-25-17)14-16-18(28-8-26-14)29-9-27-16/h1-4,6,8-9,31H,5,7H2,(H,25,30)(H,26,27,28,29)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205010
PNG
(US9550781, 7 | n-(3-(3-(9h-purin-6-yl)pyridin-2-yl...)
Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C19H17ClFN7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205013
PNG
(US9550781, 10 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES FCCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C19H16F3N7O2S/c20-6-2-8-32(30,31)29-13-5-4-12(21)16(14(13)22)28-18-11(3-1-7-23-18)15-17-19(26-9-24-15)27-10-25-17/h1,3-5,7,9-10,29H,2,6,8H2,(H,23,28)(H,24,25,26,27)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205008
PNG
(US9550781, 5 | n-(3-(3-(9h-purin-6-yl)pyridin-2-yl...)
Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C19H18ClN7O2S/c1-2-8-30(28,29)27-12-5-6-14(20)15(9-12)26-18-13(4-3-7-21-18)16-17-19(24-10-22-16)25-11-23-17/h3-7,9-11,27H,2,8H2,1H3,(H,21,26)(H,22,23,24,25)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM197706
PNG
(US9216981, 35 | US9550781, 15)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C22H15F2N7O2S/c23-15-8-9-16(31-34(32,33)13-5-2-1-3-6-13)17(24)19(15)30-21-14(7-4-10-25-21)18-20-22(28-11-26-18)29-12-27-20/h1-12,31H,(H,25,30)(H,26,27,28,29)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205007
PNG
(US9550781, 4 | n-(3-(3-(9h-purin-6-yl)pyridin-2-yl...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C19H18FN7O2S/c1-2-8-30(28,29)27-12-5-6-14(20)15(9-12)26-18-13(4-3-7-21-18)16-17-19(24-10-22-16)25-11-23-17/h3-7,9-11,27H,2,8H2,1H3,(H,21,26)(H,22,23,24,25)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205012
PNG
(US9550781, 9 | n-(3-(3-(9h-purin-6-yl)pyridin-2-yl...)
Show SMILES FCCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C19H16ClF2N7O2S/c20-12-4-5-13(29-32(30,31)8-2-6-21)14(22)16(12)28-18-11(3-1-7-23-18)15-17-19(26-9-24-15)27-10-25-17/h1,3-5,7,9-10,29H,2,6,8H2,(H,23,28)(H,24,25,26,27)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205040
PNG
(US9550781, 27 | n-(3-(2-(9h-purin-6-yl)phenylamino...)
Show SMILES CCCS(=O)(=O)Nc1ccc(C)c(Nc2ccccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C21H22N6O2S/c1-3-10-30(28,29)27-15-9-8-14(2)18(11-15)26-17-7-5-4-6-16(17)19-20-21(24-12-22-19)25-13-23-20/h4-9,11-13,26-27H,3,10H2,1-2H3,(H,22,23,24,25)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205011
PNG
(US9550781, 8 | n-(3-(3-(9h-purin-6-yl)pyridin-2-yl...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1Cl
Show InChI InChI=1S/C19H17ClFN7O2S/c1-2-8-31(29,30)28-13-6-5-12(21)16(14(13)20)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM197689
PNG
(US9216981, 17 | US9550781, 24)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccsc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C20H13F2N7O2S2/c21-13-3-4-14(29-33(30,31)11-5-7-32-8-11)15(22)17(13)28-19-12(2-1-6-23-19)16-18-20(26-9-24-16)27-10-25-18/h1-10,29H,(H,23,28)(H,24,25,26,27)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205009
PNG
(US9550781, 6 | n-(3-(3-(9h-purin-6-yl)pyridin-2-yl...)
Show SMILES CCCS(=O)(=O)Nc1ccc(C)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C20H21N7O2S/c1-3-9-30(28,29)27-14-7-6-13(2)16(10-14)26-19-15(5-4-8-21-19)17-18-20(24-11-22-17)25-12-23-18/h4-8,10-12,27H,3,9H2,1-2H3,(H,21,26)(H,22,23,24,25)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM197677
PNG
(US9216981, 5 | US9550781, 1)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-13-6-5-12(20)16(14(13)21)27-18-11(4-3-7-22-18)15-17-19(25-9-23-15)26-10-24-17/h3-7,9-10,28H,2,8H2,1H3,(H,22,27)(H,23,24,25,26)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205024
PNG
(US9550781, 21 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES Fc1ccc(NS(=O)(=O)C2CC2c2ccccc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H19F2N7O2S/c26-17-8-9-18(34-37(35,36)19-11-16(19)14-5-2-1-3-6-14)20(27)22(17)33-24-15(7-4-10-28-24)21-23-25(31-12-29-21)32-13-30-23/h1-10,12-13,16,19,34H,11H2,(H,28,33)(H,29,30,31,32)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205014
PNG
(US9550781, 11 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES Fc1ccc(NS(=O)(=O)CCl)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C17H12ClF2N7O2S/c18-6-30(28,29)27-11-4-3-10(19)14(12(11)20)26-16-9(2-1-5-21-16)13-15-17(24-7-22-13)25-8-23-15/h1-5,7-8,27H,6H2,(H,21,26)(H,22,23,24,25)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205017
PNG
(US9550781, 14 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES Fc1ccc(cc1F)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C22H13F4N7O2S/c23-13-4-3-11(8-15(13)25)36(34,35)33-16-6-5-14(24)19(17(16)26)32-21-12(2-1-7-27-21)18-20-22(30-9-28-18)31-10-29-20/h1-10,33H,(H,27,32)(H,28,29,30,31)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205035
PNG
(US9550781, 25 | n-(3-(3-(1h-pyrazolo[3,4-d]pyrimid...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]ncc23)c1F
Show InChI InChI=1S/C19H17F2N7O2S/c1-2-8-31(29,30)28-14-6-5-13(20)17(15(14)21)26-18-11(4-3-7-22-18)16-12-9-25-27-19(12)24-10-23-16/h3-7,9-10,28H,2,8H2,1H3,(H,22,26)(H,23,24,25,27)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205023
PNG
(US9550781, 20 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES Fc1ccc(NS(=O)(=O)C=C)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C18H13F2N7O2S/c1-2-30(28,29)27-12-6-5-11(19)15(13(12)20)26-17-10(4-3-7-21-17)14-16-18(24-8-22-14)25-9-23-16/h2-9,27H,1H2,(H,21,26)(H,22,23,24,25)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205038
PNG
(US9550781, 26 | n-(3-(3-(7h-pyrrolo[2,3-d]pyrimidi...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C20H18F2N6O2S/c1-2-10-31(29,30)28-15-6-5-14(21)18(16(15)22)27-20-12(4-3-8-23-20)17-13-7-9-24-19(13)26-11-25-17/h3-9,11,28H,2,10H2,1H3,(H,23,27)(H,24,25,26)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM50165871
PNG
(CHEMBL3798635 | US9550781, 13)
Show SMILES CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C17H13F2N7O2S/c1-29(27,28)26-11-5-4-10(18)14(12(11)19)25-16-9(3-2-6-20-16)13-15-17(23-7-21-13)24-8-22-15/h2-8,26H,1H3,(H,20,25)(H,21,22,23,24)
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US Patent
n/an/a<500n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205020
PNG
(US9550781, 17 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C22H14ClF2N7O2S/c23-12-3-5-13(6-4-12)35(33,34)32-16-8-7-15(24)19(17(16)25)31-21-14(2-1-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30)
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Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205005
PNG
(US9550781, 3 | n-(2,4-difluoro-3-(3-(8-methyl-9h-p...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]c(C)nc23)c1F
Show InChI InChI=1S/C20H19F2N7O2S/c1-3-9-32(30,31)29-14-7-6-13(21)17(15(14)22)28-19-12(5-4-8-23-19)16-18-20(25-10-24-16)27-11(2)26-18/h4-8,10,29H,3,9H2,1-2H3,(H,23,28)(H,24,25,26,27)
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n/an/a<500n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM50165865
PNG
(CHEMBL3798423 | US9550781, 23)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C22H14F3N7O2S/c23-12-3-5-13(6-4-12)35(33,34)32-16-8-7-15(24)19(17(16)25)31-21-14(2-1-9-26-21)18-20-22(29-10-27-18)30-11-28-20/h1-11,32H,(H,26,31)(H,27,28,29,30)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205015
PNG
(US9550781, 12 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES CCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C18H15F2N7O2S/c1-2-30(28,29)27-12-6-5-11(19)15(13(12)20)26-17-10(4-3-7-21-17)14-16-18(24-8-22-14)25-9-23-16/h3-9,27H,2H2,1H3,(H,21,26)(H,22,23,24,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205042
PNG
(US9550781, 28 | n-(3-(2-(9h-purin-6-yl)phenylamino...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C20H18F2N6O2S/c1-2-9-31(29,30)28-15-8-7-13(21)18(16(15)22)27-14-6-4-3-5-12(14)17-19-20(25-10-23-17)26-11-24-19/h3-8,10-11,27-28H,2,9H2,1H3,(H,23,24,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
b-raf


()
BDBM205025
PNG
(US9550781, 22 | n-(3-(3-(9h-purin-6-yl)pyridin-2-y...)
Show SMILES COc1ccc(cc1)C1CC1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C26H21F2N7O3S/c1-38-15-6-4-14(5-7-15)17-11-20(17)39(36,37)35-19-9-8-18(27)23(21(19)28)34-25-16(3-2-10-29-25)22-24-26(32-12-30-22)33-13-31-24/h2-10,12-13,17,20,35H,11H2,1H3,(H,29,34)(H,30,31,32,33)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

US Patent


Assay Description
In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...


US Patent US9550781 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%