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Patent code US9556130

Compile Data Set for Download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 139


(Homo sapiens)
BDBM263478
PNG
((s)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(...)
Show SMILES C[C@H](NC(=O)Cn1nnc2c(C)cc(C)cc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C20H22N4O2/c1-12-5-7-16(8-6-12)15(4)21-18(25)11-24-20(26)17-10-13(2)9-14(3)19(17)22-23-24/h5-10,15H,11H2,1-4H3,(H,21,25)/t15-/m0/s1
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10n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263499
PNG
((s)?n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Show SMILES COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(cc3F)C(F)(F)F)c(=O)c12
Show InChI InChI=1S/C19H16F4N4O3/c1-10(12-7-6-11(8-13(12)20)19(21,22)23)24-16(28)9-27-18(29)17-14(25-26-27)4-3-5-15(17)30-2/h3-8,10H,9H2,1-2H3,(H,24,28)/t10-/m0/s1
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11n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263493
PNG
((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Show SMILES COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(cc3)C(F)(F)F)c(=O)c12
Show InChI InChI=1S/C19H17F3N4O3/c1-11(12-6-8-13(9-7-12)19(20,21)22)23-16(27)10-26-18(28)17-14(24-25-26)4-3-5-15(17)29-2/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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26n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263461
PNG
((s)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(...)
Show SMILES C[C@H](NC(=O)Cn1nnc2c(Cl)cc(Cl)cc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H16Cl2N4O2/c1-10-3-5-12(6-4-10)11(2)21-16(25)9-24-18(26)14-7-13(19)8-15(20)17(14)22-23-24/h3-8,11H,9H2,1-2H3,(H,21,25)/t11-/m0/s1
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26n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263504
PNG
((s)?n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Show SMILES COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3F)c(=O)c12
Show InChI InChI=1S/C19H16F4N4O4/c1-10(12-7-6-11(8-13(12)20)31-19(21,22)23)24-16(28)9-27-18(29)17-14(25-26-27)4-3-5-15(17)30-2/h3-8,10H,9H2,1-2H3,(H,24,28)/t10-/m0/s1
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33n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263490
PNG
((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c12
Show InChI InChI=1S/C19H17F3N4O4/c1-11(12-6-8-13(9-7-12)30-19(20,21)22)23-16(27)10-26-18(28)17-14(24-25-26)4-3-5-15(17)29-2/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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33n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263484
PNG
((s)?n-(1-(2,4-dimethylphenyl)ethyl)-2-(6-fluoro-4-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C)cc1C
Show InChI InChI=1S/C19H19FN4O2/c1-11-4-6-15(12(2)8-11)13(3)21-18(25)10-24-19(26)16-9-14(20)5-7-17(16)22-23-24/h4-9,13H,10H2,1-3H3,(H,21,25)/t13-/m0/s1
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39n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263487
PNG
((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H14F4N4O3/c1-10(11-2-5-13(6-3-11)29-18(20,21)22)23-16(27)9-26-17(28)14-8-12(19)4-7-15(14)24-25-26/h2-8,10H,9H2,1H3,(H,23,27)/t10-/m0/s1
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42n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263369
PNG
((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c12
Show InChI InChI=1S/C19H20N4O3/c1-12-7-9-14(10-8-12)13(2)20-17(24)11-23-19(25)18-15(21-22-23)5-4-6-16(18)26-3/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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48n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263453
PNG
((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(C)cc3)c(=O)c2c1
Show InChI InChI=1S/C19H20N4O3/c1-12-4-6-14(7-5-12)13(2)20-18(24)11-23-19(25)16-10-15(26-3)8-9-17(16)21-22-23/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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58n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263420
PNG
((s)?n-(1-(2,4-dimethylphenyl)ethyl)-2-(4-oxobenzo[...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1C
Show InChI InChI=1S/C19H20N4O2/c1-12-8-9-15(13(2)10-12)14(3)20-18(24)11-23-19(25)16-6-4-5-7-17(16)21-22-23/h4-10,14H,11H2,1-3H3,(H,20,24)/t14-/m0/s1
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63n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263459
PNG
((s)-2-(8-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2c(C)cccc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H20N4O2/c1-12-7-9-15(10-8-12)14(3)20-17(24)11-23-19(25)16-6-4-5-13(2)18(16)21-22-23/h4-10,14H,11H2,1-3H3,(H,20,24)/t14-/m0/s1
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72n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263486
PNG
((s)?n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(6-fluo...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C)cc1F
Show InChI InChI=1S/C18H16F2N4O2/c1-10-3-5-13(15(20)7-10)11(2)21-17(25)9-24-18(26)14-8-12(19)4-6-16(14)22-23-24/h3-8,11H,9H2,1-2H3,(H,21,25)/t11-/m0/s1
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77n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263482
PNG
((s)-2-(8-fluoro-6-methyl-4-oxobenzo[d][1,2,3]triaz...)
Show SMILES C[C@H](NC(=O)Cn1nnc2c(F)cc(C)cc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H19FN4O2/c1-11-4-6-14(7-5-11)13(3)21-17(25)10-24-19(26)15-8-12(2)9-16(20)18(15)22-23-24/h4-9,13H,10H2,1-3H3,(H,21,25)/t13-/m0/s1
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85n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263474
PNG
((s)-2-(5-methyl-4-oxobenzo[d][1,2,3]triazin-3 (4h)...)
Show SMILES C[C@H](NC(=O)Cn1nnc2cccc(C)c2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H20N4O2/c1-12-7-9-15(10-8-12)14(3)20-17(24)11-23-19(25)18-13(2)5-4-6-16(18)21-22-23/h4-10,14H,11H2,1-3H3,(H,20,24)/t14-/m0/s1
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92n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263503
PNG
((s)?n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)(F)F)cc1F
Show InChI InChI=1S/C18H13F5N4O3/c1-9(12-4-3-11(7-14(12)20)30-18(21,22)23)24-16(28)8-27-17(29)13-6-10(19)2-5-15(13)25-26-27/h2-7,9H,8H2,1H3,(H,24,28)/t9-/m0/s1
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93n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263496
PNG
((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H14F4N4O2/c1-10(11-2-4-12(5-3-11)18(20,21)22)23-16(27)9-26-17(28)14-8-13(19)6-7-15(14)24-25-26/h2-8,10H,9H2,1H3,(H,23,27)/t10-/m0/s1
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106n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263457
PNG
((s)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2c(Cl)cccc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H17ClN4O2/c1-11-6-8-13(9-7-11)12(2)20-16(24)10-23-18(25)14-4-3-5-15(19)17(14)21-22-23/h3-9,12H,10H2,1-2H3,(H,20,24)/t12-/m0/s1
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110n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263492
PNG
((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(cc3)C(F)(F)F)c(=O)c2c1
Show InChI InChI=1S/C19H17F3N4O3/c1-11(12-3-5-13(6-4-12)19(20,21)22)23-17(27)10-26-18(28)15-9-14(29-2)7-8-16(15)24-25-26/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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115n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263509
PNG
(US9556130, test 81 | n-(2-chloro-4-methoxyphenethy...)
Show SMILES COc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)c(Cl)c1
Show InChI InChI=1S/C18H17ClN4O3/c1-26-13-7-6-12(15(19)10-13)8-9-20-17(24)11-23-18(25)14-4-2-3-5-16(14)21-22-23/h2-7,10H,8-9,11H2,1H3,(H,20,24)
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117n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263368
PNG
((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Show SMILES O=C(NC1CCC(CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1cccs1
Show InChI InChI=1S/C24H30N4OS2/c29-24(22-6-3-17-30-22)25-19-9-7-18(8-10-19)11-12-27-13-15-28(16-14-27)23-20-4-1-2-5-21(20)31-26-23/h1-6,17-19H,7-16H2,(H,25,29)
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119n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263502
PNG
((s)?n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1F
Show InChI InChI=1S/C18H14F4N4O3/c1-10(12-7-6-11(8-14(12)19)29-18(20,21)22)23-16(27)9-26-17(28)13-4-2-3-5-15(13)24-25-26/h2-8,10H,9H2,1H3,(H,23,27)/t10-/m0/s1
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120n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263501
PNG
((s)?n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(5-me...)
Show SMILES COc1cccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)F)cc3)c(=O)c12
Show InChI InChI=1S/C19H18F2N4O4/c1-11(12-6-8-13(9-7-12)29-19(20)21)22-16(26)10-25-18(27)17-14(23-24-25)4-3-5-15(17)28-2/h3-9,11,19H,10H2,1-2H3,(H,22,26)/t11-/m0/s1
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120n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263489
PNG
((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1ccc2nnn(CC(=O)N[C@@H](C)c3ccc(OC(F)(F)F)cc3)c(=O)c2c1
Show InChI InChI=1S/C19H17F3N4O4/c1-11(12-3-5-13(6-4-12)30-19(20,21)22)23-17(27)10-26-18(28)15-9-14(29-2)7-8-16(15)24-25-26/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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128n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263440
PNG
((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H15F3N4O2/c1-11(12-6-8-13(9-7-12)18(19,20)21)22-16(26)10-25-17(27)14-4-2-3-5-15(14)23-24-25/h2-9,11H,10H2,1H3,(H,22,26)/t11-/m0/s1
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148n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263497
PNG
((s)?n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C18H14F4N4O2/c1-10(12-7-6-11(8-14(12)19)18(20,21)22)23-16(27)9-26-17(28)13-4-2-3-5-15(13)24-25-26/h2-8,10H,9H2,1H3,(H,23,27)/t10-/m0/s1
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152n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263485
PNG
((s)?n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(4-oxob...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1F
Show InChI InChI=1S/C18H17FN4O2/c1-11-7-8-13(15(19)9-11)12(2)20-17(24)10-23-18(25)14-5-3-4-6-16(14)21-22-23/h3-9,12H,10H2,1-2H3,(H,20,24)/t12-/m0/s1
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171n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263456
PNG
((s)-2-(7-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2cc(Cl)ccc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H17ClN4O2/c1-11-3-5-13(6-4-11)12(2)20-17(24)10-23-18(25)15-8-7-14(19)9-16(15)21-22-23/h3-9,12H,10H2,1-2H3,(H,20,24)/t12-/m0/s1
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173n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263463
PNG
((s)-2-(6-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(C)cc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H20N4O2/c1-12-4-7-15(8-5-12)14(3)20-18(24)11-23-19(25)16-10-13(2)6-9-17(16)21-22-23/h4-10,14H,11H2,1-3H3,(H,20,24)/t14-/m0/s1
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179n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263479
PNG
((s)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2c(C)cc(C)cc2c1=O
Show InChI InChI=1S/C20H22N4O3/c1-12-9-13(2)19-17(10-12)20(26)24(23-22-19)11-18(25)21-14(3)15-5-7-16(27-4)8-6-15/h5-10,14H,11H2,1-4H3,(H,21,25)/t14-/m0/s1
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179n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263445
PNG
((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H17FN4O2/c1-11-3-5-13(6-4-11)12(2)20-17(24)10-23-18(25)15-9-14(19)7-8-16(15)21-22-23/h3-9,12H,10H2,1-2H3,(H,20,24)/t12-/m0/s1
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182n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263511
PNG
((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Show SMILES CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C19H17F3N4O3/c1-2-15(12-7-9-13(10-8-12)29-19(20,21)22)23-17(27)11-26-18(28)14-5-3-4-6-16(14)24-25-26/h3-10,15H,2,11H2,1H3,(H,23,27)/t15-/m0/s1
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183n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263454
PNG
((s)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3 (4h)...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(Cl)cc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H17ClN4O2/c1-11-3-5-13(6-4-11)12(2)20-17(24)10-23-18(25)15-9-14(19)7-8-16(15)21-22-23/h3-9,12H,10H2,1-2H3,(H,20,24)/t12-/m0/s1
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189n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263462
PNG
((s)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2c(Cl)cc(Cl)cc2c1=O
Show InChI InChI=1S/C18H16Cl2N4O3/c1-10(11-3-5-13(27-2)6-4-11)21-16(25)9-24-18(26)14-7-12(19)8-15(20)17(14)22-23-24/h3-8,10H,9H2,1-2H3,(H,21,25)/t10-/m0/s1
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190n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263512
PNG
((s)-2-(4-oxobenzo[d][1,2,3]triazin-3 (4h)-yl)-n-(1...)
Show SMILES CC[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N4O2/c1-2-15(12-7-9-13(10-8-12)19(20,21)22)23-17(27)11-26-18(28)14-5-3-4-6-16(14)24-25-26/h3-10,15H,2,11H2,1H3,(H,23,27)/t15-/m0/s1
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214n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263488
PNG
((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1ccc2c(c1)nnn(CC(=O)N[C@@H](C)c1ccc(OC(F)(F)F)cc1)c2=O
Show InChI InChI=1S/C19H17F3N4O4/c1-11(12-3-5-13(6-4-12)30-19(20,21)22)23-17(27)10-26-18(28)15-8-7-14(29-2)9-16(15)24-25-26/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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218n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263391
PNG
((s)?n-(1-(4-chlorophenyl)ethyl)-2-(4-oxobenzo[d][1...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN4O2/c1-11(12-6-8-13(18)9-7-12)19-16(23)10-22-17(24)14-4-2-3-5-15(14)20-21-22/h2-9,11H,10H2,1H3,(H,19,23)/t11-/m0/s1
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228n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263494
PNG
((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1cccc2c1nnn(CC(=O)N[C@@H](C)c1ccc(OC(F)(F)F)cc1)c2=O
Show InChI InChI=1S/C19H17F3N4O4/c1-11(12-6-8-13(9-7-12)30-19(20,21)22)23-16(27)10-26-18(28)14-4-3-5-15(29-2)17(14)24-25-26/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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240n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263500
PNG
((s)?n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(6-fl...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(F)cc2c1=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C18H15F3N4O3/c1-10(11-2-5-13(6-3-11)28-18(20)21)22-16(26)9-25-17(27)14-8-12(19)4-7-15(14)23-24-25/h2-8,10,18H,9H2,1H3,(H,22,26)/t10-/m0/s1
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282n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263469
PNG
((s)-2-(7-methyl-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2cc(C)ccc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H20N4O2/c1-12-4-7-15(8-5-12)14(3)20-18(24)11-23-19(25)16-9-6-13(2)10-17(16)21-22-23/h4-10,14H,11H2,1-3H3,(H,20,24)/t14-/m0/s1
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347n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263495
PNG
((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Show SMILES COc1cccc2c1nnn(CC(=O)N[C@@H](C)c1ccc(cc1)C(F)(F)F)c2=O
Show InChI InChI=1S/C19H17F3N4O3/c1-11(12-6-8-13(9-7-12)19(20,21)22)23-16(27)10-26-18(28)14-4-3-5-15(29-2)17(14)24-25-26/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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352n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263491
PNG
((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1ccc2c(c1)nnn(CC(=O)N[C@@H](C)c1ccc(cc1)C(F)(F)F)c2=O
Show InChI InChI=1S/C19H17F3N4O3/c1-11(12-3-5-13(6-4-12)19(20,21)22)23-17(27)10-26-18(28)15-8-7-14(29-2)9-16(15)24-25-26/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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375n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263480
PNG
((s)-2-(4-oxo-6-(trifluoromethyl)benzo[d][1,2,3]tri...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccc(cc2c1=O)C(F)(F)F)c1ccc(C)cc1
Show InChI InChI=1S/C19H17F3N4O2/c1-11-3-5-13(6-4-11)12(2)23-17(27)10-26-18(28)15-9-14(19(20,21)22)7-8-16(15)24-25-26/h3-9,12H,10H2,1-2H3,(H,23,27)/t12-/m0/s1
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435n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263471
PNG
((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1ccc2c(c1)nnn(CC(=O)N[C@@H](C)c1ccc(C)cc1)c2=O
Show InChI InChI=1S/C19H20N4O3/c1-12-4-6-14(7-5-12)13(2)20-18(24)11-23-19(25)16-9-8-15(26-3)10-17(16)21-22-23/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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437n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263467
PNG
((s)-2-(5-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2cccc(F)c2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H17FN4O2/c1-11-6-8-13(9-7-11)12(2)20-16(24)10-23-18(25)17-14(19)4-3-5-15(17)21-22-23/h3-9,12H,10H2,1-2H3,(H,20,24)/t12-/m0/s1
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459n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263370
PNG
((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H18N4O2/c1-12-7-9-14(10-8-12)13(2)19-17(23)11-22-18(24)15-5-3-4-6-16(15)20-21-22/h3-10,13H,11H2,1-2H3,(H,19,23)/t13-/m0/s1
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467n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263460
PNG
((s)?n-(1-(4-methoxyphenyl)ethyl)-2-(8-methyl-4-oxo...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2c(C)cccc2c1=O
Show InChI InChI=1S/C19H20N4O3/c1-12-5-4-6-16-18(12)21-22-23(19(16)25)11-17(24)20-13(2)14-7-9-15(26-3)10-8-14/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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526n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263477
PNG
((s)?n-(1-(4-methoxyphenyl)ethyl)-2-(5-methyl-4-oxo...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2cccc(C)c2c1=O
Show InChI InChI=1S/C19H20N4O3/c1-12-5-4-6-16-18(12)19(25)23(22-21-16)11-17(24)20-13(2)14-7-9-15(26-3)10-8-14/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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533n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263455
PNG
((s)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C18H17ClN4O3/c1-11(12-3-6-14(26-2)7-4-12)20-17(24)10-23-18(25)15-9-13(19)5-8-16(15)21-22-23/h3-9,11H,10H2,1-2H3,(H,20,24)/t11-/m0/s1
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551n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263473
PNG
((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2cccc(OC)c2c1=O
Show InChI InChI=1S/C19H20N4O4/c1-12(13-7-9-14(26-2)10-8-13)20-17(24)11-23-19(25)18-15(21-22-23)5-4-6-16(18)27-3/h4-10,12H,11H2,1-3H3,(H,20,24)/t12-/m0/s1
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619n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263498
PNG
((s)?n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(4-ox...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C18H16F2N4O3/c1-11(12-6-8-13(9-7-12)27-18(19)20)21-16(25)10-24-17(26)14-4-2-3-5-15(14)22-23-24/h2-9,11,18H,10H2,1H3,(H,21,25)/t11-/m0/s1
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677n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263451
PNG
((s)-2-(8-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2c(F)cccc2c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C18H17FN4O2/c1-11-6-8-13(9-7-11)12(2)20-16(24)10-23-18(25)14-4-3-5-15(19)17(14)21-22-23/h3-9,12H,10H2,1-2H3,(H,20,24)/t12-/m0/s1
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708n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263465
PNG
((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1cccc2c1nnn(CC(=O)N[C@@H](C)c1ccc(C)cc1)c2=O
Show InChI InChI=1S/C19H20N4O3/c1-12-7-9-14(10-8-12)13(2)20-17(24)11-23-19(25)15-5-4-6-16(26-3)18(15)21-22-23/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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791n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263510
PNG
((s)?n-(1-(4-methoxyphenyl)propan-2-yl)-2-(4-oxoben...)
Show SMILES COc1ccc(C[C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)cc1
Show InChI InChI=1S/C19H20N4O3/c1-13(11-14-7-9-15(26-2)10-8-14)20-18(24)12-23-19(25)16-5-3-4-6-17(16)21-22-23/h3-10,13H,11-12H2,1-2H3,(H,20,24)/t13-/m0/s1
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802n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263458
PNG
((s)-2-(8-chloro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2c(Cl)cccc2c1=O
Show InChI InChI=1S/C18H17ClN4O3/c1-11(12-6-8-13(26-2)9-7-12)20-16(24)10-23-18(25)14-4-3-5-15(19)17(14)21-22-23/h3-9,11H,10H2,1-2H3,(H,20,24)/t11-/m0/s1
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842n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263450
PNG
((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2ccc(F)cc2c1=O
Show InChI InChI=1S/C18H17FN4O3/c1-11(12-3-6-14(26-2)7-4-12)20-17(24)10-23-18(25)15-9-13(19)5-8-16(15)21-22-23/h3-9,11H,10H2,1-2H3,(H,20,24)/t11-/m0/s1
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909n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263464
PNG
((s)?n-(1-(4-methoxyphenyl)ethyl)-2-(6-methyl-4-oxo...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2ccc(C)cc2c1=O
Show InChI InChI=1S/C19H20N4O3/c1-12-4-9-17-16(10-12)19(25)23(22-21-17)11-18(24)20-13(2)14-5-7-15(26-3)8-6-14/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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915n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263435
PNG
((s)?n-(1-(4-ethoxyphenyl)ethyl)-2-(4-oxobenzo[d][1...)
Show SMILES CCOc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O
Show InChI InChI=1S/C19H20N4O3/c1-3-26-15-10-8-14(9-11-15)13(2)20-18(24)12-23-19(25)16-6-4-5-7-17(16)21-22-23/h4-11,13H,3,12H2,1-2H3,(H,20,24)/t13-/m0/s1
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953n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263433
PNG
((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1C
Show InChI InChI=1S/C18H18N4O2/c1-12-7-3-4-8-14(12)13(2)19-17(23)11-22-18(24)15-9-5-6-10-16(15)20-21-22/h3-10,13H,11H2,1-2H3,(H,19,23)/t13-/m0/s1
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1.15E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263505
PNG
(US9556130, test 74 | n-(4-chlorophenethyl)-2-(4-ox...)
Show SMILES Clc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1
Show InChI InChI=1S/C17H15ClN4O2/c18-13-7-5-12(6-8-13)9-10-19-16(23)11-22-17(24)14-3-1-2-4-15(14)20-21-22/h1-8H,9-11H2,(H,19,23)
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1.24E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263385
PNG
((s)?n-(1-(4-methoxyphenyl)ethyl)-2-(4-oxobenzo[d][...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O
Show InChI InChI=1S/C18H18N4O3/c1-12(13-7-9-14(25-2)10-8-13)19-17(23)11-22-18(24)15-5-3-4-6-16(15)20-21-22/h3-10,12H,11H2,1-2H3,(H,19,23)/t12-/m0/s1
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1.36E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263472
PNG
((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2cc(OC)ccc2c1=O
Show InChI InChI=1S/C19H20N4O4/c1-12(13-4-6-14(26-2)7-5-13)20-18(24)11-23-19(25)16-9-8-15(27-3)10-17(16)21-22-23/h4-10,12H,11H2,1-3H3,(H,20,24)/t12-/m0/s1
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1.47E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263470
PNG
((s)?n-(1-(4-methoxyphenyl)ethyl)-2-(7-methyl-4-oxo...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2cc(C)ccc2c1=O
Show InChI InChI=1S/C19H20N4O3/c1-12-4-9-16-17(10-12)21-22-23(19(16)25)11-18(24)20-13(2)14-5-7-15(26-3)8-6-14/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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1.52E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263483
PNG
((s)?n-(1-(2-methoxy-4-methylphenyl)ethyl)-2-(4-oxo...)
Show SMILES COc1cc(C)ccc1[C@H](C)NC(=O)Cn1nnc2ccccc2c1=O
Show InChI InChI=1S/C19H20N4O3/c1-12-8-9-14(17(10-12)26-3)13(2)20-18(24)11-23-19(25)15-6-4-5-7-16(15)21-22-23/h4-10,13H,11H2,1-3H3,(H,20,24)/t13-/m0/s1
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1.56E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263367
PNG
((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Show SMILES C[C@H](NC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1
Show InChI InChI=1S/C17H16N4O2/c1-12(13-7-3-2-4-8-13)18-16(22)11-21-17(23)14-9-5-6-10-15(14)19-20-21/h2-10,12H,11H2,1H3,(H,18,22)/t12-/m0/s1
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1.62E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263506
PNG
(US9556130, test 75 | n-(3-chlorophenethyl)-2-(4-ox...)
Show SMILES Clc1cccc(CCNC(=O)Cn2nnc3ccccc3c2=O)c1
Show InChI InChI=1S/C17H15ClN4O2/c18-13-5-3-4-12(10-13)8-9-19-16(23)11-22-17(24)14-6-1-2-7-15(14)20-21-22/h1-7,10H,8-9,11H2,(H,19,23)
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1.69E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263481
PNG
((s)?n-(1-(4-methoxyphenyl)ethyl)-2-(4-oxo-6-(trifl...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2ccc(cc2c1=O)C(F)(F)F
Show InChI InChI=1S/C19H17F3N4O3/c1-11(12-3-6-14(29-2)7-4-12)23-17(27)10-26-18(28)15-9-13(19(20,21)22)5-8-16(15)24-25-26/h3-9,11H,10H2,1-2H3,(H,23,27)/t11-/m0/s1
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2.53E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263437
PNG
((s)?n-(1-(2,4-dimethoxyphenyl)ethyl)-2-(4-oxobenzo...)
Show SMILES COc1ccc([C@H](C)NC(=O)Cn2nnc3ccccc3c2=O)c(OC)c1
Show InChI InChI=1S/C19H20N4O4/c1-12(14-9-8-13(26-2)10-17(14)27-3)20-18(24)11-23-19(25)15-6-4-5-7-16(15)21-22-23/h4-10,12H,11H2,1-3H3,(H,20,24)/t12-/m0/s1
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2.64E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263452
PNG
((s)-2-(8-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2c(F)cccc2c1=O
Show InChI InChI=1S/C18H17FN4O3/c1-11(12-6-8-13(26-2)9-7-12)20-16(24)10-23-18(25)14-4-3-5-15(19)17(14)21-22-23/h3-9,11H,10H2,1-2H3,(H,20,24)/t11-/m0/s1
UniProtKB/SwissProt

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3.60E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263466
PNG
((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2c(OC)cccc2c1=O
Show InChI InChI=1S/C19H20N4O4/c1-12(13-7-9-14(26-2)10-8-13)20-17(24)11-23-19(25)15-5-4-6-16(27-3)18(15)21-22-23/h4-10,12H,11H2,1-3H3,(H,20,24)/t12-/m0/s1
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4.19E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263508
PNG
((r)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(2-...)
Show SMILES C[C@@H](CNC(=O)Cn1nnc2ccccc2c1=O)c1ccccc1
Show InChI InChI=1S/C18H18N4O2/c1-13(14-7-3-2-4-8-14)11-19-17(23)12-22-18(24)15-9-5-6-10-16(15)20-21-22/h2-10,13H,11-12H2,1H3,(H,19,23)/t13-/m0/s1
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4.45E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263468
PNG
((s)-2-(5-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Show SMILES COc1ccc(cc1)[C@H](C)NC(=O)Cn1nnc2cccc(F)c2c1=O
Show InChI InChI=1S/C18H17FN4O3/c1-11(12-6-8-13(26-2)9-7-12)20-16(24)10-23-18(25)17-14(19)4-3-5-15(17)21-22-23/h3-9,11H,10H2,1-2H3,(H,20,24)/t11-/m0/s1
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4.85E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 139


(Homo sapiens)
BDBM263507
PNG
(US9556130, test 76 | n-(4-methylphenethyl)-2-(4-ox...)
Show SMILES Cc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1
Show InChI InChI=1S/C18H18N4O2/c1-13-6-8-14(9-7-13)10-11-19-17(23)12-22-18(24)15-4-2-3-5-16(15)20-21-22/h2-9H,10-12H2,1H3,(H,19,23)
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5.55E+3n/an/an/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...


US Patent US9556130 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%