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Found 6 Enz. Inhib. hit(s) with all data for entry = 197
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM227712(US9556157, 3 | n-((5-amino-2,6-dimethyl-4-oxo-1,4-...)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM227711(US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...)
Affinity DataIC50:  32nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM227712(US9556157, 3 | n-((5-amino-2,6-dimethyl-4-oxo-1,4-...)
Affinity DataIC50:  32nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM227711(US9556157, 2 | n-((2,6-dimethyl-4-oxo-1,4-dihydrop...)
Affinity DataIC50:  100nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM227713(2-bromo-n-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-...)
Affinity DataIC50:  160nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM227710( N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)me...)
Affinity DataIC50:  316nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent