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Patent code US9556168

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235032
PNG
(US9556168, 10B)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2c(Cl)cccc2C(F)(F)F)c2cc(cc(F)c12)C(=O)N1CCC1
Show InChI InChI=1S/C26H17ClF5N3O4/c27-17-4-1-3-16(26(30,31)32)15(17)11-35-20-8-12(24(37)34-5-2-6-34)7-19(29)22(20)23(33-35)13-10-21(36)14(25(38)39)9-18(13)28/h1,3-4,7-10,36H,2,5-6,11H2,(H,38,39)
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n/an/a 1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235033
PNG
(US9556168, 10C)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C(F)(F)F)c3cc(cc(F)c23)C(=O)N2CCC2)c(F)c1
Show InChI InChI=1S/C26H17ClF5N3O3/c27-18-4-1-3-17(26(30,31)32)16(18)12-35-21-11-14(24(36)34-7-2-8-34)10-20(29)22(21)23(33-35)15-6-5-13(25(37)38)9-19(15)28/h1,3-6,9-11H,2,7-8,12H2,(H,37,38)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235011
PNG
(Preparation of 4-(1-(2-bromo-6-(trifluoromethyl)be...)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2c(Br)cccc2C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C22H12BrF5N2O3/c23-14-4-1-3-13(22(26,27)28)12(14)9-30-17-6-2-5-15(24)19(17)20(29-30)10-8-18(31)11(21(32)33)7-16(10)25/h1-8,31H,9H2,(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235000
PNG
(US9556168, 1AA)
Show SMILES OC(=O)c1ccc(cc1O)-c1nn(Cc2c(Cl)cccc2C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C22H14ClF3N2O3/c23-17-6-3-5-16(22(24,25)26)15(17)11-28-18-7-2-1-4-13(18)20(27-28)12-8-9-14(21(30)31)19(29)10-12/h1-10,29H,11H2,(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235031
PNG
(Preparation of sodium 4-(1-(2-chloro-6-(trifluorom...)
Show SMILES COC1CN(C1)C(=O)c1cc(F)c2c(nn(Cc3c(Cl)cccc3C(F)(F)F)c2c1)-c1cc(O)c(cc1F)C([O-])=O
Show InChI InChI=1S/C27H19ClF5N3O5/c1-41-13-9-35(10-13)25(38)12-5-20(30)23-21(6-12)36(11-16-17(27(31,32)33)3-2-4-18(16)28)34-24(23)14-8-22(37)15(26(39)40)7-19(14)29/h2-8,13,37H,9-11H2,1H3,(H,39,40)/p-1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235021
PNG
(US9556168, 4M)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C22H12ClF5N2O3/c23-14-4-1-3-13(22(26,27)28)12(14)9-30-17-6-2-5-15(24)19(17)20(29-30)10-8-18(31)11(21(32)33)7-16(10)25/h1-8,31H,9H2,(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235023
PNG
(US9556168, 4L)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2c(F)cccc2C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C22H12F6N2O3/c23-14-4-1-3-13(22(26,27)28)12(14)9-30-17-6-2-5-15(24)19(17)20(29-30)10-8-18(31)11(21(32)33)7-16(10)25/h1-8,31H,9H2,(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235027
PNG
(Preparation of 5-fluoro-4-(4-fluoro-1-(2-methyl-6-...)
Show SMILES COC(=O)c1cc(F)c(cc1O)-c1nn(Cc2c(C)cccc2C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C24H17F5N2O3/c1-12-5-3-6-16(24(27,28)29)15(12)11-31-19-8-4-7-17(25)21(19)22(30-31)13-10-20(32)14(9-18(13)26)23(33)34-2/h3-10,32H,11H2,1-2H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235030
PNG
(US9556168, 9B)
Show SMILES CC(C)c1cccc(c1Cn1nc(-c2cc(O)c(cc2F)C(O)=O)c2c(F)cccc12)C(F)(F)F
Show InChI InChI=1S/C25H19F5N2O3/c1-12(2)13-5-3-6-17(25(28,29)30)16(13)11-32-20-8-4-7-18(26)22(20)23(31-32)14-10-21(33)15(24(34)35)9-19(14)27/h3-10,12,33H,11H2,1-2H3,(H,34,35)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235025
PNG
(Preparation of 4-(1-(2-chloro-6-methylbenzyl)-4-fl...)
Show SMILES Cc1cccc(Cl)c1Cn1nc(-c2cc(O)c(cc2F)C(O)=O)c2c(F)cccc12
Show InChI InChI=1S/C22H15ClF2N2O3/c1-11-4-2-5-15(23)14(11)10-27-18-7-3-6-16(24)20(18)21(26-27)12-9-19(28)13(22(29)30)8-17(12)25/h2-9,28H,10H2,1H3,(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235024
PNG
(Preparation of 4-(1-(2-chloro-6-cyclopropylbenzyl)...)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2c(Cl)cccc2C2CC2)c2cccc(F)c12
Show InChI InChI=1S/C24H17ClF2N2O3/c25-17-4-1-3-13(12-7-8-12)16(17)11-29-20-6-2-5-18(26)22(20)23(28-29)14-10-21(30)15(24(31)32)9-19(14)27/h1-6,9-10,12,30H,7-8,11H2,(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235002
PNG
(US9556168, 2B)
Show SMILES OC(=O)c1ccc(-c2cn(Cc3c(Cl)cccc3C(F)(F)F)c3cnccc23)c(F)c1
Show InChI InChI=1S/C22H13ClF4N2O2/c23-18-3-1-2-17(22(25,26)27)16(18)11-29-10-15(14-6-7-28-9-20(14)29)13-5-4-12(21(30)31)8-19(13)24/h1-10H,11H2,(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234976
PNG
(US9556168, 1C)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)c(F)c1
Show InChI InChI=1S/C22H12ClF5N2O2/c23-15-4-1-3-14(22(26,27)28)13(15)10-30-18-6-2-5-16(24)19(18)20(29-30)12-8-7-11(21(31)32)9-17(12)25/h1-9H,10H2,(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234977
PNG
(US9556168, 1D)
Show SMILES OC(=O)c1ccc(cc1)-c1nn(Cc2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C22H13ClF4N2O2/c23-16-4-1-3-15(22(25,26)27)14(16)11-29-18-6-2-5-17(24)19(18)20(28-29)12-7-9-13(10-8-12)21(30)31/h1-10H,11H2,(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235012
PNG
(US9556168, 4B)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2c(F)cccc2Cl)c2cccc(F)c12
Show InChI InChI=1S/C21H12ClF3N2O3/c22-13-3-1-4-14(23)12(13)9-27-17-6-2-5-15(24)19(17)20(26-27)10-8-18(28)11(21(29)30)7-16(10)25/h1-8,28H,9H2,(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235009
PNG
(US9556168, 3G)
Show SMILES OC(=O)c1ccc(cc1)-c1nn(Cc2c(Cl)cccc2Cl)c2cccc(F)c12
Show InChI InChI=1S/C21H13Cl2FN2O2/c22-15-3-1-4-16(23)14(15)11-26-18-6-2-5-17(24)19(18)20(25-26)12-7-9-13(10-8-12)21(27)28/h1-10H,11H2,(H,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235028
PNG
(US9556168, 8B)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2ccccc2C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C22H13F5N2O3/c23-15-6-3-7-17-19(15)20(12-9-18(30)13(21(31)32)8-16(12)24)28-29(17)10-11-4-1-2-5-14(11)22(25,26)27/h1-9,30H,10H2,(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234974
PNG
(4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-1H-pyraz...)
Show SMILES COC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C(F)(F)F)c3cnccc23)c(F)c1
Show InChI InChI=1S/C22H14ClF4N3O2/c1-32-21(31)12-5-6-13(18(24)9-12)20-14-7-8-28-10-19(14)30(29-20)11-15-16(22(25,26)27)3-2-4-17(15)23/h2-10H,11H2,1H3
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235029
PNG
(Preparation of 4-(1-(2-ethyl-6-(trifluoromethyl)be...)
Show SMILES CCc1cccc(c1Cn1nc(-c2cc(O)c(cc2F)C(O)=O)c2c(F)cccc12)C(F)(F)F
Show InChI InChI=1S/C24H17F5N2O3/c1-2-12-5-3-6-16(24(27,28)29)15(12)11-31-19-8-4-7-17(25)21(19)22(30-31)13-10-20(32)14(23(33)34)9-18(13)26/h3-10,32H,2,11H2,1H3,(H,33,34)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235016
PNG
(US9556168, 4F)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2cc(F)ccc2Br)c2cccc(F)c12
Show InChI InChI=1S/C21H12BrF3N2O3/c22-14-5-4-11(23)6-10(14)9-27-17-3-1-2-15(24)19(17)20(26-27)12-8-18(28)13(21(29)30)7-16(12)25/h1-8,28H,9H2,(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234978
PNG
(US9556168, 1E)
Show SMILES OC(=O)c1c(F)cc(cc1F)-c1nn(Cc2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C22H11ClF6N2O2/c23-13-4-1-3-12(22(27,28)29)11(13)9-31-17-6-2-5-14(24)19(17)20(30-31)10-7-15(25)18(21(32)33)16(26)8-10/h1-8H,9H2,(H,32,33)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235001
PNG
(Preparation of 4-(1-(2-chloro-6-(trifluoromethyl)b...)
Show SMILES OC(=O)c1ccc(-c2cn(Cc3c(Cl)cccc3C(F)(F)F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C22H13ClF4N2O2/c23-17-4-1-3-16(22(25,26)27)15(17)11-29-10-14(20-19(29)5-2-8-28-20)13-7-6-12(21(30)31)9-18(13)24/h1-10H,11H2,(H,30,31)
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n/an/a 283n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235018
PNG
(US9556168, 4H)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2cc(Cl)cc(Cl)c2)c2cccc(F)c12
Show InChI InChI=1S/C21H12Cl2F2N2O3/c22-11-4-10(5-12(23)6-11)9-27-17-3-1-2-15(24)19(17)20(26-27)13-8-18(28)14(21(29)30)7-16(13)25/h1-8,28H,9H2,(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235017
PNG
(US9556168, 4G)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2cc(F)cc(Cl)c2)c2cccc(F)c12
Show InChI InChI=1S/C21H12ClF3N2O3/c22-11-4-10(5-12(23)6-11)9-27-17-3-1-2-15(24)19(17)20(26-27)13-8-18(28)14(21(29)30)7-16(13)25/h1-8,28H,9H2,(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234981
PNG
(US9556168, 1H)
Show SMILES C[C@@H](c1c(Cl)cccc1C(F)(F)F)n1nc(-c2ccc(cc2F)C(O)=O)c2c(F)cccc12
Show InChI InChI=1S/C23H14ClF5N2O2/c1-11(19-14(23(27,28)29)4-2-5-15(19)24)31-18-7-3-6-16(25)20(18)21(30-31)13-9-8-12(22(32)33)10-17(13)26/h2-11H,1H3,(H,32,33)/t11-/m0/s1
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235026
PNG
(Preparation of 4-(1-(2-chloro-6-(1-hydroxycyclobut...)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C3(O)CCC3)c3cccc(F)c23)c(F)c1
Show InChI InChI=1S/C25H19ClF2N2O3/c26-18-5-1-4-17(25(33)10-3-11-25)16(18)13-30-21-7-2-6-19(27)22(21)23(29-30)15-9-8-14(24(31)32)12-20(15)28/h1-2,4-9,12,33H,3,10-11,13H2,(H,31,32)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234999
PNG
(US9556168, 1Z)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3C(F)(F)F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C21H12ClF4N3O2/c22-15-4-1-3-14(21(24,25)26)13(15)10-29-17-5-2-8-27-19(17)18(28-29)12-7-6-11(20(30)31)9-16(12)23/h1-9H,10H2,(H,30,31)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235014
PNG
(US9556168, 4D)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2cc(F)ccc2Cl)c2cccc(F)c12
Show InChI InChI=1S/C21H12ClF3N2O3/c22-14-5-4-11(23)6-10(14)9-27-17-3-1-2-15(24)19(17)20(26-27)12-8-18(28)13(21(29)30)7-16(12)25/h1-8,28H,9H2,(H,29,30)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235020
PNG
(US9556168, 4J)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2cc(Cl)ccc2Cl)c2cccc(F)c12
Show InChI InChI=1S/C21H12Cl2F2N2O3/c22-11-4-5-14(23)10(6-11)9-27-17-3-1-2-15(24)19(17)20(26-27)12-8-18(28)13(21(29)30)7-16(12)25/h1-8,28H,9H2,(H,29,30)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234998
PNG
(US9556168, 1Y)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3Br)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H12BrClFN3O2/c21-14-3-1-4-15(22)13(14)10-26-17-5-2-8-24-19(17)18(25-26)12-7-6-11(20(27)28)9-16(12)23/h1-9H,10H2,(H,27,28)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235015
PNG
(US9556168, 4E)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2ccc(F)cc2Cl)c2cccc(F)c12
Show InChI InChI=1S/C21H12ClF3N2O3/c22-14-6-11(23)5-4-10(14)9-27-17-3-1-2-15(24)19(17)20(26-27)12-8-18(28)13(21(29)30)7-16(12)25/h1-8,28H,9H2,(H,29,30)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234980
PNG
(US9556168, 1G)
Show SMILES C[C@H](c1c(Cl)cccc1C(F)(F)F)n1nc(-c2ccc(cc2F)C(O)=O)c2c(F)cccc12
Show InChI InChI=1S/C23H14ClF5N2O2/c1-11(19-14(23(27,28)29)4-2-5-15(19)24)31-18-7-3-6-16(25)20(18)21(30-31)13-9-8-12(22(32)33)10-17(13)26/h2-11H,1H3,(H,32,33)/t11-/m1/s1
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235010
PNG
(US9556168, 3H)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)cccc3Cl)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H12Cl2FN3O2/c21-14-3-1-4-15(22)13(14)10-26-17-5-2-8-24-19(17)18(25-26)12-7-6-11(20(27)28)9-16(12)23/h1-9H,10H2,(H,27,28)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235007
PNG
(US9556168, 3E)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3ccccc3C#N)c3cccc(F)c23)c(F)c1
Show InChI InChI=1S/C22H13F2N3O2/c23-17-6-3-7-19-20(17)21(16-9-8-13(22(28)29)10-18(16)24)26-27(19)12-15-5-2-1-4-14(15)11-25/h1-10H,12H2,(H,28,29)
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Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234988
PNG
(US9556168, 1O)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(F)cccc3C(F)(F)F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C21H12F5N3O2/c22-15-4-1-3-14(21(24,25)26)13(15)10-29-17-5-2-8-27-19(17)18(28-29)12-7-6-11(20(30)31)9-16(12)23/h1-9H,10H2,(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235019
PNG
(US9556168, 4I)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2ccc(Br)cc2F)c2cccc(F)c12
Show InChI InChI=1S/C21H12BrF3N2O3/c22-11-5-4-10(15(24)6-11)9-27-17-3-1-2-14(23)19(17)20(26-27)12-8-18(28)13(21(29)30)7-16(12)25/h1-8,28H,9H2,(H,29,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235005
PNG
(US9556168, 3C)
Show SMILES COc1ccccc1Cn1nc(-c2ccc(cc2F)C(O)=O)c2c(F)cccc12
Show InChI InChI=1S/C22H16F2N2O3/c1-29-19-8-3-2-5-14(19)12-26-18-7-4-6-16(23)20(18)21(25-26)15-10-9-13(22(27)28)11-17(15)24/h2-11H,12H2,1H3,(H,27,28)
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US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234979
PNG
(US9556168, 1F)
Show SMILES CC(c1c(Cl)cccc1C(F)(F)F)n1nc(-c2ccc(cc2F)C(O)=O)c2c(F)cccc12
Show InChI InChI=1S/C23H14ClF5N2O2/c1-11(19-14(23(27,28)29)4-2-5-15(19)24)31-18-7-3-6-16(25)20(18)21(30-31)13-9-8-12(22(32)33)10-17(13)26/h2-11H,1H3,(H,32,33)
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US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234993
PNG
(US9556168, 1T)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(F)ccc(Cl)c3Cl)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H11Cl2F2N3O2/c21-13-5-6-14(23)12(17(13)22)9-27-16-2-1-7-25-19(16)18(26-27)11-4-3-10(20(28)29)8-15(11)24/h1-8H,9H2,(H,28,29)
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US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234985
PNG
(US9556168, 1L)
Show SMILES Cc1ccc(Cl)c(Cn2nc(-c3ccc(cc3F)C(O)=O)c3ncccc23)c1F
Show InChI InChI=1S/C21H14ClF2N3O2/c1-11-4-7-15(22)14(18(11)24)10-27-17-3-2-8-25-20(17)19(26-27)13-6-5-12(21(28)29)9-16(13)23/h2-9H,10H2,1H3,(H,28,29)
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US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234995
PNG
(US9556168, 1V)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)ccc(c3Cl)C(F)(F)F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C21H11Cl2F4N3O2/c22-14-6-5-13(21(25,26)27)17(23)12(14)9-30-16-2-1-7-28-19(16)18(29-30)11-4-3-10(20(31)32)8-15(11)24/h1-8H,9H2,(H,31,32)
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US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234975
PNG
(Preparation of 4-(1-(2-bromo-6-fluorobenzyl)-1H-py...)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(F)cccc3Br)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H12BrF2N3O2/c21-14-3-1-4-15(22)13(14)10-26-17-5-2-8-24-19(17)18(25-26)12-7-6-11(20(27)28)9-16(12)23/h1-9H,10H2,(H,27,28)
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US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235006
PNG
(US9556168, 3D)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3ccccc3-n3cccn3)c3cccc(F)c23)c(F)c1
Show InChI InChI=1S/C24H16F2N4O2/c25-18-6-3-8-21-22(18)23(17-10-9-15(24(31)32)13-19(17)26)28-30(21)14-16-5-1-2-7-20(16)29-12-4-11-27-29/h1-13H,14H2,(H,31,32)
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US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234986
PNG
(US9556168, 1M)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)ccc(F)c3F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H11ClF3N3O2/c21-13-5-6-14(22)17(24)12(13)9-27-16-2-1-7-25-19(16)18(26-27)11-4-3-10(20(28)29)8-15(11)23/h1-8H,9H2,(H,28,29)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


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More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234997
PNG
(US9556168, 1X)
Show SMILES COC(=O)c1cccc(Cl)c1Cn1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12
Show InChI InChI=1S/C22H15ClFN3O4/c1-31-22(30)13-4-2-5-16(23)15(13)11-27-18-6-3-9-25-20(18)19(26-27)14-8-7-12(21(28)29)10-17(14)24/h2-10H,11H2,1H3,(H,28,29)
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n/an/a 3.26E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235022
PNG
(US9556168, 4K)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2cc(F)cc(c2)C(F)(F)F)c2cccc(F)c12
Show InChI InChI=1S/C22H12F6N2O3/c23-12-5-10(4-11(6-12)22(26,27)28)9-30-17-3-1-2-15(24)19(17)20(29-30)13-8-18(31)14(21(32)33)7-16(13)25/h1-8,31H,9H2,(H,32,33)
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n/an/a 3.35E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234992
PNG
(US9556168, 1S)
Show SMILES COc1ccc(F)c(Cn2nc(-c3ccc(cc3F)C(O)=O)c3ncccc23)c1Cl
Show InChI InChI=1S/C21H14ClF2N3O3/c1-30-17-7-6-14(23)13(18(17)22)10-27-16-3-2-8-25-20(16)19(26-27)12-5-4-11(21(28)29)9-15(12)24/h2-9H,10H2,1H3,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234990
PNG
(US9556168, 1Q)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(F)cccc3Cl)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H12ClF2N3O2/c21-14-3-1-4-15(22)13(14)10-26-17-5-2-8-24-19(17)18(25-26)12-7-6-11(20(27)28)9-16(12)23/h1-9H,10H2,(H,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235008
PNG
(US9556168, 3F)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3cc(OC(F)(F)F)ccc3F)c3cccc(F)c23)c(F)c1
Show InChI InChI=1S/C22H12F6N2O3/c23-15-7-5-13(33-22(26,27)28)8-12(15)10-30-18-3-1-2-16(24)19(18)20(29-30)14-6-4-11(21(31)32)9-17(14)25/h1-9H,10H2,(H,31,32)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234996
PNG
(US9556168, 1W)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(Cl)ccc(Cl)c3F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H11Cl2F2N3O2/c21-13-5-6-14(22)17(24)12(13)9-27-16-2-1-7-25-19(16)18(26-27)11-4-3-10(20(28)29)8-15(11)23/h1-8H,9H2,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234991
PNG
(US9556168, 1R)
Show SMILES COc1ccc(Cl)c(Cn2nc(-c3ccc(cc3F)C(O)=O)c3ncccc23)c1F
Show InChI InChI=1S/C21H14ClF2N3O3/c1-30-17-7-6-14(22)13(18(17)24)10-27-16-3-2-8-25-20(16)19(26-27)12-5-4-11(21(28)29)9-15(12)23/h2-9H,10H2,1H3,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235013
PNG
(US9556168, 4C)
Show SMILES OC(=O)c1cc(F)c(cc1O)-c1nn(Cc2ccccc2)c2cccc(F)c12
Show InChI InChI=1S/C21H14F2N2O3/c22-15-7-4-8-17-19(15)20(24-25(17)11-12-5-2-1-3-6-12)13-10-18(26)14(21(27)28)9-16(13)23/h1-10,26H,11H2,(H,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235003
PNG
(Preparation of 3-Fluoro-4-[4-fluoro-1-(2,5-difluor...)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3cc(F)ccc3F)c3cccc(F)c23)c(F)c1
Show InChI InChI=1S/C21H12F4N2O2/c22-13-5-7-15(23)12(8-13)10-27-18-3-1-2-16(24)19(18)20(26-27)14-6-4-11(21(28)29)9-17(14)25/h1-9H,10H2,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM235004
PNG
(US9556168, 3B)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3cccc(OC(F)(F)F)c3)c3cccc(F)c23)c(F)c1
Show InChI InChI=1S/C22H13F5N2O3/c23-16-5-2-6-18-19(16)20(15-8-7-13(21(30)31)10-17(15)24)28-29(18)11-12-3-1-4-14(9-12)32-22(25,26)27/h1-10H,11H2,(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234982
PNG
(US9556168, 1I)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3cccc(F)c3Br)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H12BrF2N3O2/c21-17-12(3-1-4-14(17)22)10-26-16-5-2-8-24-19(16)18(25-26)13-7-6-11(20(27)28)9-15(13)23/h1-9H,10H2,(H,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234994
PNG
(US9556168, 1U)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3cccc4ccsc34)c3cccnc23)c(F)c1
Show InChI InChI=1S/C22H14FN3O2S/c23-17-11-14(22(27)28)6-7-16(17)19-20-18(5-2-9-24-20)26(25-19)12-15-4-1-3-13-8-10-29-21(13)15/h1-11H,12H2,(H,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234987
PNG
(US9556168, 1N)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(F)ccc(F)c3F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H11F4N3O2/c21-13-5-6-14(22)17(24)12(13)9-27-16-2-1-7-25-19(16)18(26-27)11-4-3-10(20(28)29)8-15(11)23/h1-8H,9H2,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234989
PNG
(US9556168, 1P)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3c(F)cccc3F)c3cccnc23)c(F)c1
Show InChI InChI=1S/C20H12F3N3O2/c21-14-3-1-4-15(22)13(14)10-26-17-5-2-8-24-19(17)18(25-26)12-7-6-11(20(27)28)9-16(12)23/h1-9H,10H2,(H,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234983
PNG
(US9556168, 1J)
Show SMILES OC(=O)c1ccc(-c2nn(Cc3cc(Cl)ccc3C#N)c3cccnc23)c(F)c1
Show InChI InChI=1S/C21H12ClFN4O2/c22-15-5-3-13(10-24)14(8-15)11-27-18-2-1-7-25-20(18)19(26-27)16-6-4-12(21(28)29)9-17(16)23/h1-9H,11H2,(H,28,29)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))
BDBM234984
PNG
(US9556168, 1K)
Show SMILES CC(c1ccccc1C(F)(F)F)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12
Show InChI InChI=1S/C22H15F4N3O2/c1-12(14-5-2-3-6-16(14)22(24,25)26)29-18-7-4-10-27-20(18)19(28-29)15-9-8-13(21(30)31)11-17(15)23/h2-12H,1H3,(H,30,31)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%