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Patent code US9556187

Compile Data Set for Download or QSAR

Found 1933 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198274
PNG
(US9216999, 81 | US9556187, Example 81)
Show SMILES O[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C13H15N5O/c19-9-3-1-8(2-4-9)11-12-10-5-6-14-13(10)15-7-18(12)17-16-11/h5-9,14,19H,1-4H2/t8-,9-
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UniChem
n/an/a 0.0840n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198643
PNG
(US9216999, 435b | US9556187, Example 435b)
Show SMILES N#CC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H16N6/c16-7-5-10-1-3-11(4-2-10)13-14-12-6-8-17-15(12)18-9-21(14)20-19-13/h6,8-11,17H,1-5H2/t10-,11-
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n/an/a 0.110n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198634
PNG
(US9216999, 427 | US9556187, Example 427)
Show SMILES CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H20N6O2S/c1-24(22,23)18-8-10-2-4-11(5-3-10)13-14-12-6-7-16-15(12)17-9-21(14)20-19-13/h6-7,9-11,16,18H,2-5,8H2,1H3/t10-,11-
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n/an/a 0.160n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198268
PNG
(US9216999, 75 | US9556187, Example 75)
Show SMILES ClC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16ClN5/c15-7-9-1-3-10(4-2-9)12-13-11-5-6-16-14(11)17-8-20(13)19-18-12/h5-6,8-10,16H,1-4,7H2/t9-,10-
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n/an/a 0.200n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198587
PNG
(US9216999, 382b | US9556187, Example 382b)
Show SMILES FC(F)(Br)CN[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H17BrF2N6/c16-15(17,18)7-20-10-3-1-9(2-4-10)12-13-11-5-6-19-14(11)21-8-24(13)23-22-12/h5-6,8-10,19-20H,1-4,7H2/t9-,10-
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n/an/a 0.310n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198245
PNG
(US9216999, 53 | US9556187, Example 53)
Show SMILES Fc1cc(cc(F)c1CN1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)C#N
Show InChI InChI=1S/C20H17F2N7/c21-16-7-12(9-23)8-17(22)15(16)10-28-5-2-13(3-6-28)18-19-14-1-4-24-20(14)25-11-29(19)27-26-18/h1,4,7-8,11,13,24H,2-3,5-6,10H2
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n/an/a 0.320n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM275285
PNG
(US9556187, Example 369)
Show SMILES [N-]=[N+]=NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
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n/an/a 0.330n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198269
PNG
(US9216999, 76 | US9556187, Example 76)
Show SMILES SC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H17N5S/c20-7-9-1-3-10(4-2-9)12-13-11-5-6-15-14(11)16-8-19(13)18-17-12/h5-6,8-10,15,20H,1-4,7H2/t9-,10-
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n/an/a 0.330n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198267
PNG
(US9216999, 74 | US9556187, Example 74)
Show SMILES BrC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16BrN5/c15-7-9-1-3-10(4-2-9)12-13-11-5-6-16-14(11)17-8-20(13)19-18-12/h5-6,8-10,16H,1-4,7H2/t9-,10-
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n/an/a 0.400n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198272
PNG
(US9216999, 79 | US9556187, Example 79)
Show SMILES FC(F)[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H15F2N5/c15-13(16)9-3-1-8(2-4-9)11-12-10-5-6-17-14(10)18-7-21(12)20-19-11/h5-9,13,17H,1-4H2/t8-,9-
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n/an/a 0.400n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198228
PNG
(US9216999, 36 | US9556187, Example 36)
Show SMILES Cc1noc(C)c1CN1CCC(CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C18H21N7O/c1-11-15(12(2)26-22-11)9-24-7-4-13(5-8-24)16-17-14-3-6-19-18(14)20-10-25(17)23-21-16/h3,6,10,13,19H,4-5,7-9H2,1-2H3
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n/an/a 0.580n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198241
PNG
(US9216999, 49 | US9556187, Example 49)
Show SMILES Clc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)s1
Show InChI InChI=1S/C17H17ClN6S/c18-14-2-1-12(25-14)9-23-7-4-11(5-8-23)15-16-13-3-6-19-17(13)20-10-24(16)22-21-15/h1-3,6,10-11,19H,4-5,7-9H2
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n/an/a 0.610n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198343
PNG
(US9216999, 144 | US9556187, Example 144)
Show SMILES N#Cc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)s1
Show InChI InChI=1S/C18H17N7S/c19-9-13-1-2-14(26-13)10-24-7-4-12(5-8-24)16-17-15-3-6-20-18(15)21-11-25(17)23-22-16/h1-3,6,11-12,20H,4-5,7-8,10H2
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n/an/a 0.660n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198357
PNG
(US9216999, 158 | US9556187, Example 158)
Show SMILES Fc1cc(Cl)ccc1CN1CCC(CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C19H18ClFN6/c20-14-2-1-13(16(21)9-14)10-26-7-4-12(5-8-26)17-18-15-3-6-22-19(15)23-11-27(18)25-24-17/h1-3,6,9,11-12,22H,4-5,7-8,10H2
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n/an/a 0.700n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198218
PNG
(US9216999, 26 | US9556187, Example 84)
Show SMILES O=C(OCc1ccccc1)N1CCC(CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C20H20N6O2/c27-20(28-12-14-4-2-1-3-5-14)25-10-7-15(8-11-25)17-18-16-6-9-21-19(16)22-13-26(18)24-23-17/h1-6,9,13,15,21H,7-8,10-12H2
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n/an/a 0.75n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198441
PNG
(US9216999, 238 | US9556187, Example 238)
Show SMILES Brc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)s1
Show InChI InChI=1S/C17H17BrN6S/c18-14-2-1-12(25-14)9-23-7-4-11(5-8-23)15-16-13-3-6-19-17(13)20-10-24(16)22-21-15/h1-3,6,10-11,19H,4-5,7-9H2
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n/an/a 0.790n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198264
PNG
(US9216999, 71 | US9556187, Example 71)
Show SMILES CC(=O)SC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H19N5OS/c1-10(22)23-8-11-2-4-12(5-3-11)14-15-13-6-7-17-16(13)18-9-21(15)20-19-14/h6-7,9,11-12,17H,2-5,8H2,1H3/t11-,12-
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n/an/a 0.940n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198349
PNG
(US9216999, 150 | US9556187, Example 150)
Show SMILES Clc1ncc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)s1
Show InChI InChI=1S/C16H16ClN7S/c17-16-19-7-11(25-16)8-23-5-2-10(3-6-23)13-14-12-1-4-18-15(12)20-9-24(14)22-21-13/h1,4,7,9-10,18H,2-3,5-6,8H2
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n/an/a 0.980n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198570
PNG
(US9216999, 367 | US9556187, Example 367)
Show SMILES IC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16IN5/c15-7-9-1-3-10(4-2-9)12-13-11-5-6-16-14(11)17-8-20(13)19-18-12/h5-6,8-10,16H,1-4,7H2/t9-,10-
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n/an/a 0.990n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
jak2


(Homo sapiens (Human))
BDBM198268
PNG
(US9216999, 75 | US9556187, Example 75)
Show SMILES ClC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16ClN5/c15-7-9-1-3-10(4-2-9)12-13-11-5-6-16-14(11)17-8-20(13)19-18-12/h5-6,8-10,16H,1-4,7H2/t9-,10-
PDB

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n/an/a 1n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198470
PNG
(US9216999, 267 | US9556187, Example 267)
Show SMILES O[C@@H]1CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)C1
Show InChI InChI=1S/C18H24N6O/c25-14-6-8-23(10-14)9-12-1-3-13(4-2-12)16-17-15-5-7-19-18(15)20-11-24(17)22-21-16/h5,7,11-14,19,25H,1-4,6,8-10H2/t12-,13-,14-/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198352
PNG
(US9216999, 153 | US9556187, Example 153)
Show SMILES Brc1ncc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)s1
Show InChI InChI=1S/C16H16BrN7S/c17-16-19-7-11(25-16)8-23-5-2-10(3-6-23)13-14-12-1-4-18-15(12)20-9-24(14)22-21-13/h1,4,7,9-10,18H,2-3,5-6,8H2
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198456
PNG
(US9216999, 253 | US9556187, Example 253)
Show SMILES O=C1SCCC1NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C18H22N6OS/c25-18-14(6-8-26-18)20-9-11-1-3-12(4-2-11)15-16-13-5-7-19-17(13)21-10-24(16)23-22-15/h5,7,10-12,14,19-20H,1-4,6,8-9H2/t11-,12-,14?
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198233
PNG
(US9216999, 41 | US9556187, Example 41)
Show SMILES Brc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1
Show InChI InChI=1S/C19H19BrN6/c20-15-3-1-13(2-4-15)11-25-9-6-14(7-10-25)17-18-16-5-8-21-19(16)22-12-26(18)24-23-17/h1-5,8,12,14,21H,6-7,9-11H2
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198387
PNG
(US9216999, 188 | US9556187, Example 188)
Show SMILES FC(F)(F)CNC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H19F3N6/c17-16(18,19)8-20-7-10-1-3-11(4-2-10)13-14-12-5-6-21-15(12)22-9-25(14)24-23-13/h5-6,9-11,20-21H,1-4,7-8H2/t10-,11-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198246
PNG
(US9216999, 54 | US9556187, Example 54)
Show SMILES Clc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1
Show InChI InChI=1S/C19H19ClN6/c20-15-3-1-13(2-4-15)11-25-9-6-14(7-10-25)17-18-16-5-8-21-19(16)22-12-26(18)24-23-17/h1-5,8,12,14,21H,6-7,9-11H2
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198595
PNG
(US9216999, 388b | US9556187, Example 388b)
Show SMILES COc1ccc(cc1)C(O)(CN[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O2/c1-34-17-8-4-15(5-9-17)22(33,23(24,25)26)12-28-16-6-2-14(3-7-16)19-20-18-10-11-27-21(18)29-13-32(20)31-30-19/h4-5,8-11,13-14,16,27-28,33H,2-3,6-7,12H2,1H3/t14-,16-,22?
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
jak2


(Homo sapiens (Human))
BDBM198634
PNG
(US9216999, 427 | US9556187, Example 427)
Show SMILES CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H20N6O2S/c1-24(22,23)18-8-10-2-4-11(5-3-10)13-14-12-6-7-16-15(12)17-9-21(14)20-19-13/h6-7,9-11,16,18H,2-5,8H2,1H3/t10-,11-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198309
PNG
(US9216999, 116 | US9556187, Example 116)
Show SMILES Fc1ccc(NC[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)c(c1)C#N
Show InChI InChI=1S/C21H20FN7/c22-16-5-6-18(15(9-16)10-23)25-11-13-1-3-14(4-2-13)19-20-17-7-8-24-21(17)26-12-29(20)28-27-19/h5-9,12-14,24-25H,1-4,11H2/t13-,14-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198247
PNG
(US9216999, 55 | US9556187, Example 55)
Show SMILES Fc1cccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)c1
Show InChI InChI=1S/C19H19FN6/c20-15-3-1-2-13(10-15)11-25-8-5-14(6-9-25)17-18-16-4-7-21-19(16)22-12-26(18)24-23-17/h1-4,7,10,12,14,21H,5-6,8-9,11H2
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198268
PNG
(US9216999, 75 | US9556187, Example 75)
Show SMILES ClC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16ClN5/c15-7-9-1-3-10(4-2-9)12-13-11-5-6-16-14(11)17-8-20(13)19-18-12/h5-6,8-10,16H,1-4,7H2/t9-,10-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198571
PNG
(US9216999, 368 | US9556187, Example 368)
Show SMILES FC(F)(F)S(=O)(=O)C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H16F3N5O2S/c16-15(17,18)26(24,25)7-9-1-3-10(4-2-9)12-13-11-5-6-19-14(11)20-8-23(13)22-21-12/h5-6,8-10,19H,1-4,7H2/t9-,10-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198520
PNG
(US9216999, 317 | US9556187, Example 317)
Show SMILES FC(F)(F)C(NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)C(F)(F)F
Show InChI InChI=1S/C17H18F6N6/c18-16(19,20)15(17(21,22)23)25-7-9-1-3-10(4-2-9)12-13-11-5-6-24-14(11)26-8-29(13)28-27-12/h5-6,8-10,15,24-25H,1-4,7H2/t9-,10-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198379
PNG
(US9216999, 180 | US9556187, Example 180)
Show SMILES N#CCCN(CCC#N)C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C20H24N8/c21-8-1-11-27(12-2-9-22)13-15-3-5-16(6-4-15)18-19-17-7-10-23-20(17)24-14-28(19)26-25-18/h7,10,14-16,23H,1-6,11-13H2/t15-,16-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198525
PNG
(US9216999, 322 | US9556187, Example 322)
Show SMILES Fc1ccc(cc1)C1(COC1)NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C23H25FN6O/c24-18-7-5-17(6-8-18)23(12-31-13-23)27-11-15-1-3-16(4-2-15)20-21-19-9-10-25-22(19)26-14-30(21)29-28-20/h5-10,14-16,25,27H,1-4,11-13H2/t15-,16-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198472
PNG
(US9216999, 269 | US9556187, Example 269)
Show SMILES FC(F)(Br)CNC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H19BrF2N6/c17-16(18,19)8-20-7-10-1-3-11(4-2-10)13-14-12-5-6-21-15(12)22-9-25(14)24-23-13/h5-6,9-11,20-21H,1-4,7-8H2/t10-,11-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198270
PNG
(US9216999, 77 | US9556187, Example 77)
Show SMILES CS(=O)(=O)C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H19N5O2S/c1-23(21,22)8-10-2-4-11(5-3-10)13-14-12-6-7-16-15(12)17-9-20(14)19-18-13/h6-7,9-11,16H,2-5,8H2,1H3/t10-,11-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198348
PNG
(US9216999, 149 | US9556187, Example 149)
Show SMILES Brc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)o1
Show InChI InChI=1S/C17H17BrN6O/c18-14-2-1-12(25-14)9-23-7-4-11(5-8-23)15-16-13-3-6-19-17(13)20-10-24(16)22-21-15/h1-3,6,10-11,19H,4-5,7-9H2
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198576
PNG
(US9216999, 373 | US9556187, Example 373)
Show SMILES FC(F)(F)CC(=O)NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C17H19F3N6O/c18-17(19,20)7-13(27)22-8-10-1-3-11(4-2-10)14-15-12-5-6-21-16(12)23-9-26(15)25-24-14/h5-6,9-11,21H,1-4,7-8H2,(H,22,27)/t10-,11-
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
jak2


(Homo sapiens (Human))
BDBM198245
PNG
(US9216999, 53 | US9556187, Example 53)
Show SMILES Fc1cc(cc(F)c1CN1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)C#N
Show InChI InChI=1S/C20H17F2N7/c21-16-7-12(9-23)8-17(22)15(16)10-28-5-2-13(3-6-28)18-19-14-1-4-24-20(14)25-11-29(19)27-26-18/h1,4,7-8,11,13,24H,2-3,5-6,10H2
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198440
PNG
(US9216999, 237 | US9556187, Example 237)
Show SMILES Brc1csc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)c1
Show InChI InChI=1S/C17H17BrN6S/c18-12-7-13(25-9-12)8-23-5-2-11(3-6-23)15-16-14-1-4-19-17(14)20-10-24(16)22-21-15/h1,4,7,9-11,19H,2-3,5-6,8H2
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198480
PNG
(US9216999, 277 | US9556187, Example 277)
Show SMILES O[C@H](CNC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)c1ccccc1
Show InChI InChI=1S/C22H26N6O/c29-19(16-4-2-1-3-5-16)13-23-12-15-6-8-17(9-7-15)20-21-18-10-11-24-22(18)25-14-28(21)27-26-20/h1-5,10-11,14-15,17,19,23-24,29H,6-9,12-13H2/t15-,17-,19-/m1/s1
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NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198589
PNG
(US9216999, 383b | US9556187, Example 383b)
Show SMILES FC(F)(F)C(F)(F)CN[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H17F5N6/c17-15(18,16(19,20)21)7-23-10-3-1-9(2-4-10)12-13-11-5-6-22-14(11)24-8-27(13)26-25-12/h5-6,8-10,22-23H,1-4,7H2/t9-,10-
PDB

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n/an/a 1.5n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198229
PNG
(US9216999, 37 | US9556187, Example 37)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1
Show InChI InChI=1S/C20H19F3N6O/c21-20(22,23)30-15-3-1-13(2-4-15)11-28-9-6-14(7-10-28)17-18-16-5-8-24-19(16)25-12-29(18)27-26-17/h1-5,8,12,14,24H,6-7,9-11H2
PDB

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n/an/a 1.5n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198650
PNG
(US9216999, 441 | US9556187, Example 441)
Show SMILES N#CCC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H18N6/c17-8-1-2-11-3-5-12(6-4-11)14-15-13-7-9-18-16(13)19-10-22(15)21-20-14/h7,9-12,18H,1-6H2/t11-,12-
PDB

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n/an/a 1.60n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198431
PNG
(US9216999, 228 | US9556187, Example 228)
Show SMILES Clc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)o1
Show InChI InChI=1S/C17H17ClN6O/c18-14-2-1-12(25-14)9-23-7-4-11(5-8-23)15-16-13-3-6-19-17(13)20-10-24(16)22-21-15/h1-3,6,10-11,19H,4-5,7-9H2
PDB

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n/an/a 1.60n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198358
PNG
(US9216999, 159 | US9556187, Example 159)
Show SMILES Fc1cc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)ccc1Cl
Show InChI InChI=1S/C19H18ClFN6/c20-15-2-1-12(9-16(15)21)10-26-7-4-13(5-8-26)17-18-14-3-6-22-19(14)23-11-27(18)25-24-17/h1-3,6,9,11,13,22H,4-5,7-8,10H2
PDB

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n/an/a 1.60n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM198302
PNG
(US9216999, 109 | US9556187, Example 109)
Show SMILES CC(NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H24F2N6/c1-13(16-6-7-18(23)19(24)10-16)26-11-14-2-4-15(5-3-14)20-21-17-8-9-25-22(17)27-12-30(21)29-28-20/h6-10,12-15,25-26H,2-5,11H2,1H3/t13?,14-,15-
PDB

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n/an/a 1.60n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
jak2


(Homo sapiens (Human))
BDBM198274
PNG
(US9216999, 81 | US9556187, Example 81)
Show SMILES O[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C13H15N5O/c19-9-3-1-8(2-4-9)11-12-10-5-6-14-13(10)15-7-18(12)17-16-11/h5-9,14,19H,1-4H2/t8-,9-
PDB

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n/an/a 1.60n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM275377
PNG
(1-{1-[(5-bromofuran-2-yl)methyl]piperidin- | US955...)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
PDB

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n/an/a 1.60n/an/an/an/an/an/a



NISSAN CHEMICAL INDUSTRIES, LTD.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9556187 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%