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Patent code US9566277

Compile Data Set for Download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM209856
PNG
(US9273052, 15 | US9566277, 15)
Show SMILES FC(F)(F)c1nnc2CN(CCn12)C(=O)c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1
Show InChI InChI=1S/C22H17F3N6O2/c23-22(24,25)21-29-27-18-12-30(8-9-31(18)21)20(33)14-5-3-4-13(10-14)11-17-15-6-1-2-7-16(15)19(32)28-26-17/h1-7,10H,8-9,11-12H2,(H,28,32)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30n/an/an/an/an/a25



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
he assay described below is to determine the activity of the compounds of the present invention for inhibiting the enzyme activity of PARP by using t...


US Patent US9566277 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM209854
PNG
(US9273052, 2 | US9566277, 2)
Show SMILES Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCn2cccc2C1
Show InChI InChI=1S/C23H19FN4O2/c24-20-8-7-15(13-21-17-5-1-2-6-18(17)22(29)26-25-21)12-19(20)23(30)28-11-10-27-9-3-4-16(27)14-28/h1-9,12H,10-11,13-14H2,(H,26,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/a25



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
he assay described below is to determine the activity of the compounds of the present invention for inhibiting the enzyme activity of PARP by using t...


US Patent US9566277 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM209857
PNG
(US9273052, 19 | US9566277, 19)
Show SMILES Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCn2nc(nc2C1)C(F)(F)F
Show InChI InChI=1S/C22H16F4N6O2/c23-16-6-5-12(10-17-13-3-1-2-4-14(13)19(33)29-28-17)9-15(16)20(34)31-7-8-32-18(11-31)27-21(30-32)22(24,25)26/h1-6,9H,7-8,10-11H2,(H,29,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10.2n/an/an/an/an/a25



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
he assay described below is to determine the activity of the compounds of the present invention for inhibiting the enzyme activity of PARP by using t...


US Patent US9566277 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM209853
PNG
(US9273052, 1 | US9566277, 1)
Show SMILES Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCn2c(C1)nnc2C(F)(F)F
Show InChI InChI=1S/C22H16F4N6O2/c23-16-6-5-12(10-17-13-3-1-2-4-14(13)19(33)29-27-17)9-15(16)20(34)31-7-8-32-18(11-31)28-30-21(32)22(24,25)26/h1-6,9H,7-8,10-11H2,(H,29,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/a25



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
he assay described below is to determine the activity of the compounds of the present invention for inhibiting the enzyme activity of PARP by using t...


US Patent US9566277 (2017)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (human))
BDBM209855
PNG
(US9273052, 3 | US9566277, 3)
Show SMILES COC(=O)c1nc(n2CCN(Cc12)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)C(F)(F)F
Show InChI InChI=1S/C25H19F4N5O4/c1-38-23(37)20-19-12-33(8-9-34(19)24(30-20)25(27,28)29)22(36)16-10-13(6-7-17(16)26)11-18-14-4-2-3-5-15(14)21(35)32-31-18/h2-7,10H,8-9,11-12H2,1H3,(H,32,35)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/a25



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
he assay described below is to determine the activity of the compounds of the present invention for inhibiting the enzyme activity of PARP by using t...


US Patent US9566277 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%