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Patent code US9567324

Compile Data Set for Download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287575
PNG
(US9567324, 15)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCN(CC1)C(N)=O
Show InChI InChI=1S/C25H24N6O5S/c1-16-7-10-36-21(16)24(33)29-20-4-2-3-17(13-20)5-6-18-14-19(15-28-22(18)26)23(32)30-37(35)11-8-31(9-12-37)25(27)34/h2-4,7,10,13-15H,8-9,11-12H2,1H3,(H2,26,28)(H2,27,34)(H,29,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287566
PNG
(US9567324, 6)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCN(CC1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C28H27N5O7S/c1-19-8-12-40-25(19)27(37)31-23-4-2-3-20(16-23)5-6-21-15-22(18-29-17-21)26(36)32-41(39)13-10-33(11-14-41)28(38)30-9-7-24(34)35/h2-4,8,12,15-18H,7,9-11,13-14H2,1H3,(H,30,38)(H,31,37)(H,34,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287565
PNG
(US9567324, 5)
Show SMILES CCOC(=O)CCCNC(=O)N1CCS(=O)(CC1)=NC(=O)c1cncc(c1)C#Cc1cccc(NC(=O)c2occc2C)c1
Show InChI InChI=1S/C31H33N5O7S/c1-3-42-27(37)8-5-12-33-31(40)36-13-16-44(41,17-14-36)35-29(38)25-18-24(20-32-21-25)10-9-23-6-4-7-26(19-23)34-30(39)28-22(2)11-15-43-28/h4,6-7,11,15,18-21H,3,5,8,12-14,16-17H2,1-2H3,(H,33,40)(H,34,39)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287567
PNG
(US9567324, 7)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCN(CC1)C(=O)NCCCC(O)=O
Show InChI InChI=1S/C29H29N5O7S/c1-20-9-13-41-26(20)28(38)32-24-5-2-4-21(17-24)7-8-22-16-23(19-30-18-22)27(37)33-42(40)14-11-34(12-15-42)29(39)31-10-3-6-25(35)36/h2,4-5,9,13,16-19H,3,6,10-12,14-15H2,1H3,(H,31,39)(H,32,38)(H,35,36)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287561
PNG
(US9567324, 1)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H30N4O6S/c1-20-10-13-38-25(20)27(35)31-24-7-5-6-21(17-24)8-9-22-16-23(19-30-18-22)26(34)32-40(37)14-11-33(12-15-40)28(36)39-29(2,3)4/h5-7,10,13,16-19H,11-12,14-15H2,1-4H3,(H,31,35)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287574
PNG
(US9567324, 14)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCNCC1
Show InChI InChI=1S/C24H23N5O4S/c1-16-7-10-33-21(16)24(31)28-20-4-2-3-17(13-20)5-6-18-14-19(15-27-22(18)25)23(30)29-34(32)11-8-26-9-12-34/h2-4,7,10,13-15,26H,8-9,11-12H2,1H3,(H2,25,27)(H,28,31)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287564
PNG
(US9567324, 4)
Show SMILES CCOC(=O)CCNC(=O)N1CCS(=O)(CC1)=NC(=O)c1cncc(c1)C#Cc1cccc(NC(=O)c2occc2C)c1
Show InChI InChI=1S/C30H31N5O7S/c1-3-41-26(36)9-11-32-30(39)35-12-15-43(40,16-13-35)34-28(37)24-17-23(19-31-20-24)8-7-22-5-4-6-25(18-22)33-29(38)27-21(2)10-14-42-27/h4-6,10,14,17-20H,3,9,11-13,15-16H2,1-2H3,(H,32,39)(H,33,38)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287573
PNG
(US9567324, 13)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H31N5O6S/c1-19-10-13-39-24(19)27(36)32-23-7-5-6-20(16-23)8-9-21-17-22(18-31-25(21)30)26(35)33-41(38)14-11-34(12-15-41)28(37)40-29(2,3)4/h5-7,10,13,16-18H,11-12,14-15H2,1-4H3,(H2,30,31)(H,32,36)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287563
PNG
(US9567324, 3)
Show SMILES CC(=O)N1CCS(=O)(CC1)=NC(=O)c1cncc(c1)C#Cc1cccc(NC(=O)c2occc2C)c1
Show InChI InChI=1S/C26H24N4O5S/c1-18-8-11-35-24(18)26(33)28-23-5-3-4-20(15-23)6-7-21-14-22(17-27-16-21)25(32)29-36(34)12-9-30(10-13-36)19(2)31/h3-5,8,11,14-17H,9-10,12-13H2,1-2H3,(H,28,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287562
PNG
(US9567324, 2)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCNCC1
Show InChI InChI=1S/C24H22N4O4S/c1-17-7-10-32-22(17)24(30)27-21-4-2-3-18(14-21)5-6-19-13-20(16-26-15-19)23(29)28-33(31)11-8-25-9-12-33/h2-4,7,10,13-16,25H,8-9,11-12H2,1H3,(H,27,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287572
PNG
(US9567324, 12)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCN(CC1)C(=O)NCC(O)=O
Show InChI InChI=1S/C27H25N5O7S/c1-18-7-10-39-24(18)26(36)30-22-4-2-3-19(14-22)5-6-20-13-21(16-28-15-20)25(35)31-40(38)11-8-32(9-12-40)27(37)29-17-23(33)34/h2-4,7,10,13-16H,8-9,11-12,17H2,1H3,(H,29,37)(H,30,36)(H,33,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287570
PNG
(US9567324, 10)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCN(CC1)C(=O)NCCCC(=O)NCC(O)CO
Show InChI InChI=1S/C32H36N6O8S/c1-22-9-13-46-29(22)31(43)36-26-5-2-4-23(17-26)7-8-24-16-25(19-33-18-24)30(42)37-47(45)14-11-38(12-15-47)32(44)34-10-3-6-28(41)35-20-27(40)21-39/h2,4-5,9,13,16-19,27,39-40H,3,6,10-12,14-15,20-21H2,1H3,(H,34,44)(H,35,41)(H,36,43)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287568
PNG
(US9567324, 8)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCN(CC1)C(=O)NCCC(=O)N1CCC(O)C1
Show InChI InChI=1S/C32H34N6O7S/c1-22-9-14-45-29(22)31(42)35-26-4-2-3-23(18-26)5-6-24-17-25(20-33-19-24)30(41)36-46(44)15-12-37(13-16-46)32(43)34-10-7-28(40)38-11-8-27(39)21-38/h2-4,9,14,17-20,27,39H,7-8,10-13,15-16,21H2,1H3,(H,34,43)(H,35,42)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287569
PNG
(US9567324, 9)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCN(CC1)C(=O)NCCCC(=O)N1CCC(O)C1
Show InChI InChI=1S/C33H36N6O7S/c1-23-10-15-46-30(23)32(43)36-27-5-2-4-24(19-27)7-8-25-18-26(21-34-20-25)31(42)37-47(45)16-13-38(14-17-47)33(44)35-11-3-6-29(41)39-12-9-28(40)22-39/h2,4-5,10,15,18-21,28,40H,3,6,9,11-14,16-17,22H2,1H3,(H,35,44)(H,36,43)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287571
PNG
(US9567324, 11)
Show SMILES CCOC(=O)CNC(=O)N1CCS(=O)(CC1)=NC(=O)c1cncc(c1)C#Cc1cccc(NC(=O)c2occc2C)c1
Show InChI InChI=1S/C29H29N5O7S/c1-3-40-25(35)19-31-29(38)34-10-13-42(39,14-11-34)33-27(36)23-15-22(17-30-18-23)8-7-21-5-4-6-24(16-21)32-28(37)26-20(2)9-12-41-26/h4-6,9,12,15-18H,3,10-11,13-14,19H2,1-2H3,(H,31,38)(H,32,37)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287578
PNG
(US9567324, 18)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCN(CC1)C(N)=O
Show InChI InChI=1S/C27H25FN6O4S/c1-17-5-8-23(28)22(13-17)26(36)32-21-4-2-3-18(14-21)6-7-19-15-20(16-31-24(19)29)25(35)33-39(38)11-9-34(10-12-39)27(30)37/h2-5,8,13-16H,9-12H2,1H3,(H2,29,31)(H2,30,37)(H,32,36)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287580
PNG
(US9567324, 20)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C24H22N4O5S/c1-16-7-8-33-21(16)24(30)27-20-4-2-3-17(13-20)5-6-18-14-19(15-26-22(18)25)23(29)28-34(31)11-9-32-10-12-34/h2-4,7-8,13-15H,9-12H2,1H3,(H2,25,26)(H,27,30)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287577
PNG
(US9567324, 17)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCNCC1
Show InChI InChI=1S/C26H24FN5O3S/c1-17-5-8-23(27)22(13-17)26(34)31-21-4-2-3-18(14-21)6-7-19-15-20(16-30-24(19)28)25(33)32-36(35)11-9-29-10-12-36/h2-5,8,13-16,29H,9-12H2,1H3,(H2,28,30)(H,31,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287584
PNG
(US9567324, 24)
Show SMILES CC(C)(C)c1cc(NC(=O)c2cccc(c2)C#Cc2cc(cnc2N)C(=O)N=S2(=O)CCOCC2)no1
Show InChI InChI=1S/C26H27N5O5S/c1-26(2,3)21-15-22(30-36-21)29-24(32)19-6-4-5-17(13-19)7-8-18-14-20(16-28-23(18)27)25(33)31-37(34)11-9-35-10-12-37/h4-6,13-16H,9-12H2,1-3H3,(H2,27,28)(H,29,30,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287582
PNG
(US9567324, 22)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(c2)C#Cc2cc(cnc2N)C(=O)N=S2(=O)CCOCC2)c1
Show InChI InChI=1S/C26H23FN4O4S/c1-17-5-8-22(27)23(13-17)30-25(32)20-4-2-3-18(14-20)6-7-19-15-21(16-29-24(19)28)26(33)31-36(34)11-9-35-10-12-36/h2-5,8,13-16H,9-12H2,1H3,(H2,28,29)(H,30,32)
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n/an/a 11n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287579
PNG
(US9567324, 19)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C24H21N3O5S/c1-17-7-8-32-22(17)24(29)26-21-4-2-3-18(14-21)5-6-19-13-20(16-25-15-19)23(28)27-33(30)11-9-31-10-12-33/h2-4,7-8,13-16H,9-12H2,1H3,(H,26,29)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287583
PNG
(US9567324, 23)
Show SMILES Nc1ncc(cc1C#Cc1cccc(c1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C26H20ClF3N4O4S/c27-22-7-6-20(14-21(22)26(28,29)30)33-24(35)18-3-1-2-16(12-18)4-5-17-13-19(15-32-23(17)31)25(36)34-39(37)10-8-38-9-11-39/h1-3,6-7,12-15H,8-11H2,(H2,31,32)(H,33,35)
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n/an/a 13n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287582
PNG
(US9567324, 22)
Show SMILES Cc1ccc(F)c(NC(=O)c2cccc(c2)C#Cc2cc(cnc2N)C(=O)N=S2(=O)CCOCC2)c1
Show InChI InChI=1S/C26H23FN4O4S/c1-17-5-8-22(27)23(13-17)30-25(32)20-4-2-3-18(14-20)6-7-19-15-21(16-29-24(19)28)26(33)31-36(34)11-9-35-10-12-36/h2-5,8,13-16H,9-12H2,1H3,(H2,28,29)(H,30,32)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287578
PNG
(US9567324, 18)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCN(CC1)C(N)=O
Show InChI InChI=1S/C27H25FN6O4S/c1-17-5-8-23(28)22(13-17)26(36)32-21-4-2-3-18(14-21)6-7-19-15-20(16-31-24(19)29)25(35)33-39(38)11-9-34(10-12-39)27(30)37/h2-5,8,13-16H,9-12H2,1H3,(H2,29,31)(H2,30,37)(H,32,36)
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n/an/a 15n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287576
PNG
(US9567324, 16)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H32FN5O5S/c1-20-8-11-26(32)25(16-20)29(39)35-24-7-5-6-21(17-24)9-10-22-18-23(19-34-27(22)33)28(38)36-43(41)14-12-37(13-15-43)30(40)42-31(2,3)4/h5-8,11,16-19H,12-15H2,1-4H3,(H2,33,34)(H,35,39)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287581
PNG
(US9567324, 21)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C26H23FN4O4S/c1-17-5-8-23(27)22(13-17)26(33)30-21-4-2-3-18(14-21)6-7-19-15-20(16-29-24(19)28)25(32)31-36(34)11-9-35-10-12-36/h2-5,8,13-16H,9-12H2,1H3,(H2,28,29)(H,30,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287577
PNG
(US9567324, 17)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCNCC1
Show InChI InChI=1S/C26H24FN5O3S/c1-17-5-8-23(27)22(13-17)26(34)31-21-4-2-3-18(14-21)6-7-19-15-20(16-30-24(19)28)25(33)32-36(35)11-9-29-10-12-36/h2-5,8,13-16,29H,9-12H2,1H3,(H2,28,30)(H,31,34)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287585
PNG
(US9567324, 25)
Show SMILES COc1cccc(NC(=O)c2cccc(c2)C#Cc2cc(cnc2N)C(=O)N=S2(=O)CCOCC2)c1
Show InChI InChI=1S/C26H24N4O5S/c1-34-23-7-3-6-22(16-23)29-25(31)20-5-2-4-18(14-20)8-9-19-15-21(17-28-24(19)27)26(32)30-36(33)12-10-35-11-13-36/h2-7,14-17H,10-13H2,1H3,(H2,27,28)(H,29,31)
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n/an/a 19n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287584
PNG
(US9567324, 24)
Show SMILES CC(C)(C)c1cc(NC(=O)c2cccc(c2)C#Cc2cc(cnc2N)C(=O)N=S2(=O)CCOCC2)no1
Show InChI InChI=1S/C26H27N5O5S/c1-26(2,3)21-15-22(30-36-21)29-24(32)19-6-4-5-17(13-19)7-8-18-14-20(16-28-23(18)27)25(33)31-37(34)11-9-35-10-12-37/h4-6,13-16H,9-12H2,1-3H3,(H2,27,28)(H,29,30,32)
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n/an/a 20n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287579
PNG
(US9567324, 19)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C24H21N3O5S/c1-17-7-8-32-22(17)24(29)26-21-4-2-3-18(14-21)5-6-19-13-20(16-25-15-19)23(28)27-33(30)11-9-31-10-12-33/h2-4,7-8,13-16H,9-12H2,1H3,(H,26,29)
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n/an/a 23n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287581
PNG
(US9567324, 21)
Show SMILES Cc1ccc(F)c(c1)C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C26H23FN4O4S/c1-17-5-8-23(27)22(13-17)26(33)30-21-4-2-3-18(14-21)6-7-19-15-20(16-29-24(19)28)25(32)31-36(34)11-9-35-10-12-36/h2-5,8,13-16H,9-12H2,1H3,(H2,28,29)(H,30,33)
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ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287585
PNG
(US9567324, 25)
Show SMILES COc1cccc(NC(=O)c2cccc(c2)C#Cc2cc(cnc2N)C(=O)N=S2(=O)CCOCC2)c1
Show InChI InChI=1S/C26H24N4O5S/c1-34-23-7-3-6-22(16-23)29-25(31)20-5-2-4-18(14-20)8-9-19-15-21(17-28-24(19)27)26(32)30-36(33)12-10-35-11-13-36/h2-7,14-17H,10-13H2,1H3,(H2,27,28)(H,29,31)
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n/an/a 33n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM287583
PNG
(US9567324, 23)
Show SMILES Nc1ncc(cc1C#Cc1cccc(c1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C26H20ClF3N4O4S/c27-22-7-6-20(14-21(22)26(28,29)30)33-24(35)18-3-1-2-16(12-18)4-5-17-13-19(15-32-23(17)31)25(36)34-39(37)10-8-38-9-11-39/h1-3,6-7,12-15H,8-11H2,(H2,31,32)(H,33,35)
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n/an/a 39n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM287580
PNG
(US9567324, 20)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cc(cnc1N)C(=O)N=S1(=O)CCOCC1
Show InChI InChI=1S/C24H22N4O5S/c1-16-7-8-33-21(16)24(30)27-20-4-2-3-17(13-20)5-6-18-14-19(15-26-22(18)25)23(29)28-34(31)11-9-32-10-12-34/h2-4,7-8,13-15H,9-12H2,1H3,(H2,25,26)(H,27,30)
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n/an/a 51n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9567324 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%