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Patent code US9567339

Compile Data Set for Download or QSAR

Found 358 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287156
PNG
(US9567339, Example A.1.7)
Show SMILES CC(C)Cn1cc(cn1)-c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)C=C)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287162
PNG
(US9567339, Example A.1.13)
Show SMILES COc1cc(ccn1)-c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)C=C)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287164
PNG
(US9567339, Example A.1.15)
Show SMILES CC(=O)Nc1cccc(c1)-c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)C=C)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287168
PNG
(US9567339, Example A.1.19)
Show SMILES COC(=O)c1cccc(c1)-c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)C=C)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287173
PNG
(US9567339, Example A.1.24)
Show SMILES Cc1ccc(cn1)-c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)C=C)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287182
PNG
(US9567339, Example A.1.33)
Show SMILES Cc1c(NC(=O)C=C)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)-c1ccccc1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287190
PNG
(US9567339, Example A.1.41)
Show SMILES COc1ccc(cn1)-c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)C=C)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287215
PNG
(US9567339, Example A.4.11)
Show SMILES Cc1c(NC2COC2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287236
PNG
(US9567339, Example A.7.5)
Show SMILES Cc1ccc2CN(C(=O)c2c1)c1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(cc12)-c1cccnc1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287302
PNG
(US9567339, Example D.7.7)
Show SMILES Cc1c(NC(=O)C(F)(F)Cl)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287306
PNG
(US9567339, Example D.7.11)
Show SMILES Cc1c(NC(=O)COc2ccc(F)cc2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287314
PNG
(US9567339, Example D.7.19)
Show SMILES Cc1c(NC(=O)C2=CCCCC2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287364
PNG
(US9567339, Example E.1.10)
Show SMILES NC(=O)c1cnc(-c2cccc(NC(=O)C=C)c2)c2cc[nH]c12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287404
PNG
(US9567339, Example E.9.2)
Show SMILES CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(cc12)C1CC1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287436
PNG
(US9567339, Example E.9.35)
Show SMILES CN(c1ccc(C(N)=O)c2[nH]ccc12)C1(C)CN(C1)C(=O)C=C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287439
PNG
(US9567339, Example E.9.38)
Show SMILES NC(=O)c1ccc([C@@H]2COCCN(C2)C(=O)C=C)c2cc[nH]c12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287319
PNG
(US9567339, Example D.7.24)
Show SMILES Cc1c(NC(=O)COc2ccccn2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287324
PNG
(US9567339, Example D.7.29)
Show SMILES Cc1c(NC(=O)C2CCCCC2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287330
PNG
(US9567339, Example D.7.35)
Show SMILES CC(C)CC(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287355
PNG
(US9567339, Example E.1.1 | US9567339, Example E.9....)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccc(C(N)=O)c2[nH]1)-c1ccccc1CNC(=O)C=C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287357
PNG
(US9567339, Example E.1.3)
Show SMILES NC(=O)c1ccc(-c2ccnc(NC(=O)C=C)c2)c2cc[nH]c12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287376
PNG
(US9567339, Example E.1.22)
Show SMILES NC(=O)c1ccc(-c2cc(NC(=O)C=C)c(F)cc2F)c2cc[nH]c12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287378
PNG
(US9567339, Example E.1.24)
Show SMILES NC(=O)c1ccc(-c2cc(NC(=O)C=C)ccc2Cl)c2cc[nH]c12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287379
PNG
(US9567339, Example E.1.25)
Show SMILES Cc1ccc(cc1NC(=O)C=C)-c1ccc(C(N)=O)c2[nH]ccc12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287397
PNG
(US9567339, Example E.6.1)
Show SMILES CCOC(=O)N1CC=C(C1)c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(c1C)-n1cnc2ccccc2c1=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287401
PNG
(US9567339, Example E.8.1)
Show SMILES CC(=O)N1CC=C(C1)c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(c1C)-n1cnc2ccccc2c1=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287197
PNG
(US9567339, Example A.3.1 | US9567339, Example E.8....)
Show SMILES CC(=O)N1CCC(=CC1)c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(c1C)-n1cnc2ccccc2c1=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287413
PNG
(US9567339, Example E.9.12)
Show SMILES CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(cc12)-c1ccc2CCCOc2c1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287415
PNG
(US9567339, Example E.9.14)
Show SMILES CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287417
PNG
(US9567339, Example E.9.16)
Show SMILES CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(cc12)-c1ccnn1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287420
PNG
(US9567339, Example E.9.19)
Show SMILES CN(C1CN(C1)C(=O)C=C)c1ccc(C(N)=O)c2[nH]c(cc12)C1CCS(=O)(=O)CC1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287438
PNG
(US9567339, Example E.9.37)
Show SMILES Cn1cc(cn1)-c1nc2c(cnc(C(N)=O)c2s1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C19H20N6O2S/c1-3-14(26)25-6-4-5-11(10-25)13-8-21-16(18(20)27)17-15(13)23-19(28-17)12-7-22-24(2)9-12/h3,7-9,11H,1,4-6,10H2,2H3,(H2,20,27)/t11-/m1/s1
GoogleScholar
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UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287457
PNG
(US9567339, Example G.1.1)
Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCNCC1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287459
PNG
(US9567339, Example G.1.3)
Show SMILES CNCC(=C)C(=O)Nc1cccc(c1)-c1ccc(C(N)=O)c2[nH]ccc12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287477
PNG
(US9567339, Example O.1.5*)
Show SMILES Cc1nc(co1)C(=O)NC1CCCN(C1)c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287495
PNG
(US9567339, Example O.1.25*)
Show SMILES Cn1cc(cn1)-c1cc2c(ccc(C(N)=O)c2[nH]1)N1CCC[C@H](C1)NC(=O)c1ccc(cc1)C1CC1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287184
PNG
(US9567339, Example A.1.35)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)C=C)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287200
PNG
(US9567339, Example A.3.4)
Show SMILES CC(=O)N1CCC(=CC1)c1cc2c(ccc(C(N)=O)c2[nH]1)-c1cccc(NC(=O)c2nccs2)c1C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287207
PNG
(US9567339, Example A.4.3)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1cc2c(ccc(C(N)=O)c2[nH]1)-c1ccccc1NC(=O)C=C
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287251
PNG
(US9567339, Example A.9.2)
Show SMILES NC(=O)c1ccc(-c2cccnc2)c2cc([nH]c12)-c1ccc(F)cc1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287261
PNG
(US9567339, Example A.10.5)
Show SMILES Cc1c(NC(=O)c2cc3CCCCc3s2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)-c1cnn(C)c1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287262
PNG
(US9567339, Example A.11.1)
Show SMILES Cc1c(cccc1-n1cnc2ccccc2c1=O)-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCOCC1
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287300
PNG
(US9567339, Example D.7.5)
Show SMILES CC(=C)C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287309
PNG
(US9567339, Example D.7.14)
Show SMILES Cc1c(NC(=O)COc2cccnc2)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287312
PNG
(US9567339, Example D.7.17)
Show SMILES Cc1c(NC(=O)\C=C/Cl)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287313
PNG
(US9567339, Example D.7.18)
Show SMILES COC(=O)\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287315
PNG
(US9567339, Example D.7.20)
Show SMILES CCOC(=O)\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287318
PNG
(US9567339, Example D.7.23)
Show SMILES CN(C)CCC(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287320
PNG
(US9567339, Example D.7.25)
Show SMILES Cc1c(NC(=O)\C=C\C(N)=O)cccc1-c1ccc(C(N)=O)c2[nH]c(cc12)C1=CCN(CC1)S(C)(=O)=O
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM287337
PNG
(US9567339, Example D.8.1)
Show SMILES CCOC(=O)\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]ccc12
GoogleScholar
AffyNet 
UniChem
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc.

US Patent


Assay Description
The in-house BTK corresponds to recombinant human catalytic domain (aa 393-659), which was expressed in SF9 cells with an N-terminal his tag and puri...


US Patent US9567339 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%