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Patent code US9573943

Compile Data Set for Download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119398
PNG
(US8669361, 140 | US9573943, Example 140)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)/t11-/m1/s1
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US Patent
0.0100 -62.8n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119386
PNG
(US8669361, 113 | US9573943, Example 113)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCCC(N)CC1
Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)
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US Patent
0.0220 -60.8n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119398
PNG
(US8669361, 140 | US9573943, Example 140)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)/t11-/m1/s1
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US Patent
0.0240 -60.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119386
PNG
(US8669361, 113 | US9573943, Example 113)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCCC(N)CC1
Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)
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US Patent
0.0270 -60.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119405
PNG
(US8669361, 328 | US9573943, Example 328)
Show SMILES CN[C@H]1CCCN(CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C21H25F2N7OS/c1-25-12-5-4-9-30(10-8-12)21-15(11-26-29(21)2)27-19(31)17-18(24)32-20(28-17)16-13(22)6-3-7-14(16)23/h3,6-7,11-12,25H,4-5,8-10,24H2,1-2H3,(H,27,31)/t12-/m0/s1
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US Patent
0.0960 -57.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119387
PNG
(US8669361, 114 | US9573943, Example 114)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCCC(N)CC1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-11-4-5-14(24)10-12-30)19(13-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,13-14H,4-5,10-12,24-25H2,1H3,(H,28,31)
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0.115 -56.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119387
PNG
(US8669361, 114 | US9573943, Example 114)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCCC(N)CC1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-11-4-5-14(24)10-12-30)19(13-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,13-14H,4-5,10-12,24-25H2,1H3,(H,28,31)
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0.159 -55.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119398
PNG
(US8669361, 140 | US9573943, Example 140)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)/t11-/m1/s1
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0.167 -55.8n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119405
PNG
(US8669361, 328 | US9573943, Example 328)
Show SMILES CN[C@H]1CCCN(CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C21H25F2N7OS/c1-25-12-5-4-9-30(10-8-12)21-15(11-26-29(21)2)27-19(31)17-18(24)32-20(28-17)16-13(22)6-3-7-14(16)23/h3,6-7,11-12,25H,4-5,8-10,24H2,1-2H3,(H,27,31)/t12-/m0/s1
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0.176 -55.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119400
PNG
(US8669361, 142 | US9573943, Example 142)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@H](N)CC1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-11-4-5-14(24)10-12-30)19(13-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,13-14H,4-5,10-12,24-25H2,1H3,(H,28,31)/t14-/m0/s1
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0.245 -54.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119385
PNG
(US8669361, 112 | US9573943, Example 112)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@@H](N)C1
Show InChI InChI=1S/C21H24FN7O/c1-28-21(29-10-4-5-13(23)12-29)18(11-25-28)27-20(30)19-16(24)8-9-17(26-19)14-6-2-3-7-15(14)22/h2-3,6-9,11,13H,4-5,10,12,23-24H2,1H3,(H,27,30)/t13-/m1/s1
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US Patent
0.246 -54.8n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119390
PNG
(US8669361, 119 | US9573943, Example 119)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C20H23FN8O/c1-28-20(29-8-4-5-12(22)11-29)16(10-25-28)27-19(30)17-18(23)24-9-15(26-17)13-6-2-3-7-14(13)21/h2-3,6-7,9-10,12H,4-5,8,11,22H2,1H3,(H2,23,24)(H,27,30)/t12-/m0/s1
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0.274 -54.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119393
PNG
(US8669361, 122 | US9573943, Example 122)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC(N)CC1
Show InChI InChI=1S/C20H23FN8O/c1-28-20(29-8-6-12(22)7-9-29)16(11-25-28)27-19(30)17-18(23)24-10-15(26-17)13-4-2-3-5-14(13)21/h2-5,10-12H,6-9,22H2,1H3,(H2,23,24)(H,27,30)
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0.281 -54.5n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119399
PNG
(US8669361, 141 | US9573943, Example 141)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C21H25FN8O/c1-29-21(30-9-4-5-13(23)8-10-30)17(12-26-29)28-20(31)18-19(24)25-11-16(27-18)14-6-2-3-7-15(14)22/h2-3,6-7,11-13H,4-5,8-10,23H2,1H3,(H2,24,25)(H,28,31)/t13-/m1/s1
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0.295 -54.4n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119390
PNG
(US8669361, 119 | US9573943, Example 119)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C20H23FN8O/c1-28-20(29-8-4-5-12(22)11-29)16(10-25-28)27-19(30)17-18(23)24-9-15(26-17)13-6-2-3-7-14(13)21/h2-3,6-7,9-10,12H,4-5,8,11,22H2,1H3,(H2,23,24)(H,27,30)/t12-/m0/s1
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0.305 -54.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119386
PNG
(US8669361, 113 | US9573943, Example 113)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CCCC(N)CC1
Show InChI InChI=1S/C20H23F2N7OS/c1-28-20(29-8-3-4-11(23)7-9-29)14(10-25-28)26-18(30)16-17(24)31-19(27-16)15-12(21)5-2-6-13(15)22/h2,5-6,10-11H,3-4,7-9,23-24H2,1H3,(H,26,30)
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0.316 -54.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119385
PNG
(US8669361, 112 | US9573943, Example 112)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@@H](N)C1
Show InChI InChI=1S/C21H24FN7O/c1-28-21(29-10-4-5-13(23)12-29)18(11-25-28)27-20(30)19-16(24)8-9-17(26-19)14-6-2-3-7-15(14)22/h2-3,6-9,11,13H,4-5,10,12,23-24H2,1H3,(H,27,30)/t13-/m1/s1
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0.340 -54.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119396
PNG
(US8669361, 129 | US9573943, Example 129)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@H](CN)C1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-10-4-5-14(11-24)13-30)19(12-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,12,14H,4-5,10-11,13,24-25H2,1H3,(H,28,31)/t14-/m1/s1
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US Patent
0.343 -54.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119397
PNG
(US8669361, 135 | US9573943, Example 135)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@H](CN)C1
Show InChI InChI=1S/C19H21F2N7OS/c1-27-19(28-6-5-10(7-22)9-28)13(8-24-27)25-17(29)15-16(23)30-18(26-15)14-11(20)3-2-4-12(14)21/h2-4,8,10H,5-7,9,22-23H2,1H3,(H,25,29)/t10-/m1/s1
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US Patent
0.344 -54.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119400
PNG
(US8669361, 142 | US9573943, Example 142)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@H](N)CC1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-11-4-5-14(24)10-12-30)19(13-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,13-14H,4-5,10-12,24-25H2,1H3,(H,28,31)/t14-/m0/s1
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US Patent
0.368 -53.8n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119408
PNG
(US8669361, 369 | US9573943, Example 369)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CCC(N)CC1
Show InChI InChI=1S/C20H22F2N6OS/c1-28-17(10-5-7-11(23)8-6-10)14(9-25-28)26-19(29)16-18(24)30-20(27-16)15-12(21)3-2-4-13(15)22/h2-4,9-11H,5-8,23-24H2,1H3,(H,26,29)
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0.462 -53.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119397
PNG
(US8669361, 135 | US9573943, Example 135)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@H](CN)C1
Show InChI InChI=1S/C19H21F2N7OS/c1-27-19(28-6-5-10(7-22)9-28)13(8-24-27)25-17(29)15-16(23)30-18(26-15)14-11(20)3-2-4-12(14)21/h2-4,8,10H,5-7,9,22-23H2,1H3,(H,25,29)/t10-/m1/s1
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0.506 -53.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119383
PNG
(US8669361, 107 | US9573943, Example 107)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2ccccc2F)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C19H22FN7OS/c1-26-19(27-8-4-5-11(21)10-27)14(9-23-26)24-17(28)15-16(22)29-18(25-15)12-6-2-3-7-13(12)20/h2-3,6-7,9,11H,4-5,8,10,21-22H2,1H3,(H,24,28)/t11-/m0/s1
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0.575 -52.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119408
PNG
(US8669361, 369 | US9573943, Example 369)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CCC(N)CC1
Show InChI InChI=1S/C20H22F2N6OS/c1-28-17(10-5-7-11(23)8-6-10)14(9-25-28)26-19(29)16-18(24)30-20(27-16)15-12(21)3-2-4-13(15)22/h2-4,9-11H,5-8,23-24H2,1H3,(H,26,29)
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0.735 -52.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119384
PNG
(US8669361, 109 | US9573943, Example 109)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2)c1N1CCC(N)CC1
Show InChI InChI=1S/C21H25N7O/c1-27-21(28-11-9-15(22)10-12-28)18(13-24-27)26-20(29)19-16(23)7-8-17(25-19)14-5-3-2-4-6-14/h2-8,13,15H,9-12,22-23H2,1H3,(H,26,29)
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0.762 -52.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119403
PNG
(US8669361, 238 | US9573943, Example 238)
Show SMILES Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C22H23F3N6O/c1-30-22(31-10-3-4-13(26)9-11-31)18(12-27-30)29-21(32)17-8-7-16(25)20(28-17)19-14(23)5-2-6-15(19)24/h2,5-8,12-13H,3-4,9-11,26H2,1H3,(H,29,32)/t13-/m1/s1
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0.897 -51.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119393
PNG
(US8669361, 122 | US9573943, Example 122)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC(N)CC1
Show InChI InChI=1S/C20H23FN8O/c1-28-20(29-8-6-12(22)7-9-29)16(11-25-28)27-19(30)17-18(23)24-10-15(26-17)13-4-2-3-5-14(13)21/h2-5,10-12H,6-9,22H2,1H3,(H2,23,24)(H,27,30)
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0.962 -51.5n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119388
PNG
(US8669361, 115 | US9573943, Example 115)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1OCC1CCNCC1
Show InChI InChI=1S/C20H22F2N6O2S/c1-28-20(30-10-11-5-7-24-8-6-11)14(9-25-28)26-18(29)16-17(23)31-19(27-16)15-12(21)3-2-4-13(15)22/h2-4,9,11,24H,5-8,10,23H2,1H3,(H,26,29)
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1.08 -51.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119391
PNG
(US8669361, 120 | US9573943, Example 120)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1OC1CCNCC1
Show InChI InChI=1S/C19H20F2N6O2S/c1-27-19(29-10-5-7-23-8-6-10)13(9-24-27)25-17(28)15-16(22)30-18(26-15)14-11(20)3-2-4-12(14)21/h2-4,9-10,23H,5-8,22H2,1H3,(H,25,28)
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1.10 -51.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119388
PNG
(US8669361, 115 | US9573943, Example 115)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1OCC1CCNCC1
Show InChI InChI=1S/C20H22F2N6O2S/c1-28-20(30-10-11-5-7-24-8-6-11)14(9-25-28)26-18(29)16-17(23)31-19(27-16)15-12(21)3-2-4-13(15)22/h2-4,9,11,24H,5-8,10,23H2,1H3,(H,26,29)
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1.14 -51.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119383
PNG
(US8669361, 107 | US9573943, Example 107)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2ccccc2F)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C19H22FN7OS/c1-26-19(27-8-4-5-11(21)10-27)14(9-23-26)24-17(28)15-16(22)29-18(25-15)12-6-2-3-7-13(12)20/h2-3,6-7,9,11H,4-5,8,10,21-22H2,1H3,(H,24,28)/t11-/m0/s1
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1.22 -50.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119396
PNG
(US8669361, 129 | US9573943, Example 129)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@H](CN)C1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-10-4-5-14(11-24)13-30)19(12-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,12,14H,4-5,10-11,13,24-25H2,1H3,(H,28,31)/t14-/m1/s1
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1.33 -50.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119387
PNG
(US8669361, 114 | US9573943, Example 114)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCCC(N)CC1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-11-4-5-14(24)10-12-30)19(13-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,13-14H,4-5,10-12,24-25H2,1H3,(H,28,31)
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1.65 -50.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119395
PNG
(US8669361, 124 | US9573943, Example 124)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CC[C@@H](N)C1
Show InChI InChI=1S/C20H22FN7O/c1-27-20(28-9-8-12(22)11-28)17(10-24-27)26-19(29)18-15(23)6-7-16(25-18)13-4-2-3-5-14(13)21/h2-7,10,12H,8-9,11,22-23H2,1H3,(H,26,29)/t12-/m1/s1
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1.92 -49.8n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119391
PNG
(US8669361, 120 | US9573943, Example 120)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1OC1CCNCC1
Show InChI InChI=1S/C19H20F2N6O2S/c1-27-19(29-10-5-7-23-8-6-10)13(9-24-27)25-17(28)15-16(22)30-18(26-15)14-11(20)3-2-4-12(14)21/h2-4,9-10,23H,5-8,22H2,1H3,(H,25,28)
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1.97 -49.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119390
PNG
(US8669361, 119 | US9573943, Example 119)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C20H23FN8O/c1-28-20(29-8-4-5-12(22)11-29)16(10-25-28)27-19(30)17-18(23)24-9-15(26-17)13-6-2-3-7-14(13)21/h2-3,6-7,9-10,12H,4-5,8,11,22H2,1H3,(H2,23,24)(H,27,30)/t12-/m0/s1
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2.13 -49.5n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119403
PNG
(US8669361, 238 | US9573943, Example 238)
Show SMILES Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C22H23F3N6O/c1-30-22(31-10-3-4-13(26)9-11-31)18(12-27-30)29-21(32)17-8-7-16(25)20(28-17)19-14(23)5-2-6-15(19)24/h2,5-8,12-13H,3-4,9-11,26H2,1H3,(H,29,32)/t13-/m1/s1
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2.48 -49.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119385
PNG
(US8669361, 112 | US9573943, Example 112)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@@H](N)C1
Show InChI InChI=1S/C21H24FN7O/c1-28-21(29-10-4-5-13(23)12-29)18(11-25-28)27-20(30)19-16(24)8-9-17(26-19)14-6-2-3-7-15(14)22/h2-3,6-9,11,13H,4-5,10,12,23-24H2,1H3,(H,27,30)/t13-/m1/s1
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2.49 -49.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119384
PNG
(US8669361, 109 | US9573943, Example 109)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2)c1N1CCC(N)CC1
Show InChI InChI=1S/C21H25N7O/c1-27-21(28-11-9-15(22)10-12-28)18(13-24-27)26-20(29)19-16(23)7-8-17(25-19)14-5-3-2-4-6-14/h2-8,13,15H,9-12,22-23H2,1H3,(H,26,29)
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2.63 -49.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119400
PNG
(US8669361, 142 | US9573943, Example 142)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@H](N)CC1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-11-4-5-14(24)10-12-30)19(13-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,13-14H,4-5,10-12,24-25H2,1H3,(H,28,31)/t14-/m0/s1
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3.13 -48.5n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119399
PNG
(US8669361, 141 | US9573943, Example 141)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C21H25FN8O/c1-29-21(30-9-4-5-13(23)8-10-30)17(12-26-29)28-20(31)18-19(24)25-11-16(27-18)14-6-2-3-7-15(14)22/h2-3,6-7,11-13H,4-5,8-10,23H2,1H3,(H2,24,25)(H,28,31)/t13-/m1/s1
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3.52 -48.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119395
PNG
(US8669361, 124 | US9573943, Example 124)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CC[C@@H](N)C1
Show InChI InChI=1S/C20H22FN7O/c1-27-20(28-9-8-12(22)11-28)17(10-24-27)26-19(29)18-15(23)6-7-16(25-18)13-4-2-3-5-14(13)21/h2-7,10,12H,8-9,11,22-23H2,1H3,(H,26,29)/t12-/m1/s1
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3.79 -48.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119389
PNG
(US8669361, 116 | US9573943, Example 116)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1OC1CCNCC1
Show InChI InChI=1S/C21H23FN6O2/c1-28-21(30-13-8-10-24-11-9-13)18(12-25-28)27-20(29)19-16(23)6-7-17(26-19)14-4-2-3-5-15(14)22/h2-7,12-13,24H,8-11,23H2,1H3,(H,27,29)
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4.36 -47.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119405
PNG
(US8669361, 328 | US9573943, Example 328)
Show SMILES CN[C@H]1CCCN(CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C21H25F2N7OS/c1-25-12-5-4-9-30(10-8-12)21-15(11-26-29(21)2)27-19(31)17-18(24)32-20(28-17)16-13(22)6-3-7-14(16)23/h3,6-7,11-12,25H,4-5,8-10,24H2,1-2H3,(H,27,31)/t12-/m0/s1
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4.37 -47.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119382
PNG
(US8669361, 105 | US9573943, Example 105)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1NCC1CCNCC1
Show InChI InChI=1S/C20H23F2N7OS/c1-29-18(25-9-11-5-7-24-8-6-11)14(10-26-29)27-19(30)16-17(23)31-20(28-16)15-12(21)3-2-4-13(15)22/h2-4,10-11,24-25H,5-9,23H2,1H3,(H,27,30)
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4.54 -47.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119381
PNG
(US8669361, 103 | US9573943, Example 103)
Show SMILES N[C@H]1CCCN(C1)c1[nH]ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C18H19F2N7OS/c19-10-4-1-5-11(20)13(10)18-25-14(15(22)29-18)17(28)24-12-7-23-26-16(12)27-6-2-3-9(21)8-27/h1,4-5,7,9H,2-3,6,8,21-22H2,(H,23,26)(H,24,28)/t9-/m0/s1
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4.89 -47.4n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119389
PNG
(US8669361, 116 | US9573943, Example 116)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1OC1CCNCC1
Show InChI InChI=1S/C21H23FN6O2/c1-28-21(30-13-8-10-24-11-9-13)18(12-25-28)27-20(29)19-16(23)6-7-17(26-19)14-4-2-3-5-15(14)22/h2-7,12-13,24H,8-11,23H2,1H3,(H,27,29)
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4.97 -47.4n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119402
PNG
(US8669361, 231 | US9573943, Example 231)
Show SMILES CN1CCC(CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C20H22F2N6OS/c1-27-8-6-11(7-9-27)17-14(10-24-28(17)2)25-19(29)16-18(23)30-20(26-16)15-12(21)4-3-5-13(15)22/h3-5,10-11H,6-9,23H2,1-2H3,(H,25,29)
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5.26 -47.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119382
PNG
(US8669361, 105 | US9573943, Example 105)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1NCC1CCNCC1
Show InChI InChI=1S/C20H23F2N7OS/c1-29-18(25-9-11-5-7-24-8-6-11)14(10-26-29)27-19(30)16-17(23)31-20(28-16)15-12(21)3-2-4-13(15)22/h2-4,10-11,24-25H,5-9,23H2,1H3,(H,27,30)
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5.77 -47.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119404
PNG
(US8669361, 263 | US9573943, Example 263)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CCNCC1
Show InChI InChI=1S/C19H20F2N6OS/c1-27-16(10-5-7-23-8-6-10)13(9-24-27)25-18(28)15-17(22)29-19(26-15)14-11(20)3-2-4-12(14)21/h2-4,9-10,23H,5-8,22H2,1H3,(H,25,28)
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6.12 -46.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119381
PNG
(US8669361, 103 | US9573943, Example 103)
Show SMILES N[C@H]1CCCN(C1)c1[nH]ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C18H19F2N7OS/c19-10-4-1-5-11(20)13(10)18-25-14(15(22)29-18)17(28)24-12-7-23-26-16(12)27-6-2-3-9(21)8-27/h1,4-5,7,9H,2-3,6,8,21-22H2,(H,23,26)(H,24,28)/t9-/m0/s1
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6.5 -46.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119402
PNG
(US8669361, 231 | US9573943, Example 231)
Show SMILES CN1CCC(CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C20H22F2N6OS/c1-27-8-6-11(7-9-27)17-14(10-24-28(17)2)25-19(29)16-18(23)30-20(26-16)15-12(21)4-3-5-13(15)22/h3-5,10-11H,6-9,23H2,1-2H3,(H,25,29)
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7.65 -46.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119380
PNG
(US8669361, 102 | US9573943, Example 102)
Show SMILES Cn1cc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cn1
Show InChI InChI=1S/C14H11F2N5OS/c1-21-6-7(5-18-21)19-13(22)11-12(17)23-14(20-11)10-8(15)3-2-4-9(10)16/h2-6H,17H2,1H3,(H,19,22)
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8.80 -46.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119396
PNG
(US8669361, 129 | US9573943, Example 129)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CCC[C@H](CN)C1
Show InChI InChI=1S/C22H26FN7O/c1-29-22(30-10-4-5-14(11-24)13-30)19(12-26-29)28-21(31)20-17(25)8-9-18(27-20)15-6-2-3-7-16(15)23/h2-3,6-9,12,14H,4-5,10-11,13,24-25H2,1H3,(H,28,31)/t14-/m1/s1
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10.2 -45.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119404
PNG
(US8669361, 263 | US9573943, Example 263)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CCNCC1
Show InChI InChI=1S/C19H20F2N6OS/c1-27-16(10-5-7-23-8-6-10)13(9-24-27)25-18(28)15-17(22)29-19(26-15)14-11(20)3-2-4-12(14)21/h2-4,9-10,23H,5-8,22H2,1H3,(H,25,28)
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10.4 -45.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119397
PNG
(US8669361, 135 | US9573943, Example 135)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@H](CN)C1
Show InChI InChI=1S/C19H21F2N7OS/c1-27-19(28-6-5-10(7-22)9-28)13(8-24-27)25-17(29)15-16(23)30-18(26-15)14-11(20)3-2-4-12(14)21/h2-4,8,10H,5-7,9,22-23H2,1H3,(H,25,29)/t10-/m1/s1
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10.6 -45.5n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119406
PNG
(US8669361, 353 | US9573943, Example 353)
Show SMILES Nc1sc(nc1C(=O)Nc1cnn(CCF)c1)-c1c(F)cccc1F
Show InChI InChI=1S/C15H12F3N5OS/c16-4-5-23-7-8(6-20-23)21-14(24)12-13(19)25-15(22-12)11-9(17)2-1-3-10(11)18/h1-3,6-7H,4-5,19H2,(H,21,24)
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11.9 -45.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119408
PNG
(US8669361, 369 | US9573943, Example 369)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CCC(N)CC1
Show InChI InChI=1S/C20H22F2N6OS/c1-28-17(10-5-7-11(23)8-6-10)14(9-25-28)26-19(29)16-18(24)30-20(27-16)15-12(21)3-2-4-13(15)22/h2-4,9-11H,5-8,23-24H2,1H3,(H,26,29)
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12.5 -45.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119393
PNG
(US8669361, 122 | US9573943, Example 122)
Show SMILES Cn1ncc(NC(=O)c2nc(cnc2N)-c2ccccc2F)c1N1CCC(N)CC1
Show InChI InChI=1S/C20H23FN8O/c1-28-20(29-8-6-12(22)7-9-29)16(11-25-28)27-19(30)17-18(23)24-10-15(26-17)13-4-2-3-5-14(13)21/h2-5,10-12H,6-9,22H2,1H3,(H2,23,24)(H,27,30)
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14.7 -44.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119380
PNG
(US8669361, 102 | US9573943, Example 102)
Show SMILES Cn1cc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cn1
Show InChI InChI=1S/C14H11F2N5OS/c1-21-6-7(5-18-21)19-13(22)11-12(17)23-14(20-11)10-8(15)3-2-4-9(10)16/h2-6H,17H2,1H3,(H,19,22)
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16 -44.5n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119403
PNG
(US8669361, 238 | US9573943, Example 238)
Show SMILES Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C22H23F3N6O/c1-30-22(31-10-3-4-13(26)9-11-31)18(12-27-30)29-21(32)17-8-7-16(25)20(28-17)19-14(23)5-2-6-15(19)24/h2,5-8,12-13H,3-4,9-11,26H2,1H3,(H,29,32)/t13-/m1/s1
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17.3 -44.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119406
PNG
(US8669361, 353 | US9573943, Example 353)
Show SMILES Nc1sc(nc1C(=O)Nc1cnn(CCF)c1)-c1c(F)cccc1F
Show InChI InChI=1S/C15H12F3N5OS/c16-4-5-23-7-8(6-20-23)21-14(24)12-13(19)25-15(22-12)11-9(17)2-1-3-10(11)18/h1-3,6-7H,4-5,19H2,(H,21,24)
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19 -44.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119407
PNG
(US8669361, 364 | US9573943, Example 364)
Show SMILES CCn1ncc(NC(=O)c2nc(sc2N)-c2ccccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C21H26FN7OS/c1-2-29-21(28-10-5-6-13(23)9-11-28)16(12-25-29)26-19(30)17-18(24)31-20(27-17)14-7-3-4-8-15(14)22/h3-4,7-8,12-13H,2,5-6,9-11,23-24H2,1H3,(H,26,30)/t13-/m1/s1
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20 -43.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119383
PNG
(US8669361, 107 | US9573943, Example 107)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2ccccc2F)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C19H22FN7OS/c1-26-19(27-8-4-5-11(21)10-27)14(9-23-26)24-17(28)15-16(22)29-18(25-15)12-6-2-3-7-13(12)20/h2-3,6-7,9,11H,4-5,8,10,21-22H2,1H3,(H,24,28)/t11-/m0/s1
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20.1 -43.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119401
PNG
(US8669361, 220 | US9573943, Example 220)
Show SMILES Cn1ncc(NC(=O)c2cncc(n2)-c2ccccc2F)c1N1CCC[C@H](N)CC1
Show InChI InChI=1S/C21H24FN7O/c1-28-21(29-9-4-5-14(23)8-10-29)19(13-25-28)27-20(30)18-12-24-11-17(26-18)15-6-2-3-7-16(15)22/h2-3,6-7,11-14H,4-5,8-10,23H2,1H3,(H,27,30)/t14-/m0/s1
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22 -43.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119407
PNG
(US8669361, 364 | US9573943, Example 364)
Show SMILES CCn1ncc(NC(=O)c2nc(sc2N)-c2ccccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C21H26FN7OS/c1-2-29-21(28-10-5-6-13(23)9-11-28)16(12-25-29)26-19(30)17-18(24)31-20(27-17)14-7-3-4-8-15(14)22/h3-4,7-8,12-13H,2,5-6,9-11,23-24H2,1H3,(H,26,30)/t13-/m1/s1
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24 -43.5n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119389
PNG
(US8669361, 116 | US9573943, Example 116)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1OC1CCNCC1
Show InChI InChI=1S/C21H23FN6O2/c1-28-21(30-13-8-10-24-11-9-13)18(12-25-28)27-20(29)19-16(23)6-7-17(26-19)14-4-2-3-5-15(14)22/h2-7,12-13,24H,8-11,23H2,1H3,(H,27,29)
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26.2 -43.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119391
PNG
(US8669361, 120 | US9573943, Example 120)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1OC1CCNCC1
Show InChI InChI=1S/C19H20F2N6O2S/c1-27-19(29-10-5-7-23-8-6-10)13(9-24-27)25-17(28)15-16(22)30-18(26-15)14-11(20)3-2-4-12(14)21/h2-4,9-10,23H,5-8,22H2,1H3,(H,25,28)
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28.3 -43.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119395
PNG
(US8669361, 124 | US9573943, Example 124)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2F)c1N1CC[C@@H](N)C1
Show InChI InChI=1S/C20H22FN7O/c1-27-20(28-9-8-12(22)11-28)17(10-24-27)26-19(29)18-15(23)6-7-16(25-18)13-4-2-3-5-14(13)21/h2-7,10,12H,8-9,11,22-23H2,1H3,(H,26,29)/t12-/m1/s1
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28.5 -43.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119401
PNG
(US8669361, 220 | US9573943, Example 220)
Show SMILES Cn1ncc(NC(=O)c2cncc(n2)-c2ccccc2F)c1N1CCC[C@H](N)CC1
Show InChI InChI=1S/C21H24FN7O/c1-28-21(29-9-4-5-14(23)8-10-29)19(13-25-28)27-20(30)18-12-24-11-17(26-18)15-6-2-3-7-16(15)22/h2-3,6-7,11-14H,4-5,8-10,23H2,1H3,(H,27,30)/t14-/m0/s1
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34.2 -42.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119406
PNG
(US8669361, 353 | US9573943, Example 353)
Show SMILES Nc1sc(nc1C(=O)Nc1cnn(CCF)c1)-c1c(F)cccc1F
Show InChI InChI=1S/C15H12F3N5OS/c16-4-5-23-7-8(6-20-23)21-14(24)12-13(19)25-15(22-12)11-9(17)2-1-3-10(11)18/h1-3,6-7H,4-5,19H2,(H,21,24)
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38 -42.4n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119392
PNG
(US8669361, 121 | US9573943, Example 121)
Show SMILES Cn1ncc(NC(=O)c2nc(Br)cnc2N)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C14H19BrN8O/c1-22-14(23-4-2-3-8(16)7-23)9(5-19-22)20-13(24)11-12(17)18-6-10(15)21-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,18)(H,20,24)/t8-/m0/s1
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38.8 -42.3n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119384
PNG
(US8669361, 109 | US9573943, Example 109)
Show SMILES Cn1ncc(NC(=O)c2nc(ccc2N)-c2ccccc2)c1N1CCC(N)CC1
Show InChI InChI=1S/C21H25N7O/c1-27-21(28-11-9-15(22)10-12-28)18(13-24-27)26-20(29)19-16(23)7-8-17(25-19)14-5-3-2-4-6-14/h2-8,13,15H,9-12,22-23H2,1H3,(H,26,29)
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41.1 -42.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119388
PNG
(US8669361, 115 | US9573943, Example 115)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1OCC1CCNCC1
Show InChI InChI=1S/C20H22F2N6O2S/c1-28-20(30-10-11-5-7-24-8-6-11)14(9-25-28)26-18(29)16-17(23)31-19(27-16)15-12(21)3-2-4-13(15)22/h2-4,9,11,24H,5-8,10,23H2,1H3,(H,26,29)
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46.1 -41.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119381
PNG
(US8669361, 103 | US9573943, Example 103)
Show SMILES N[C@H]1CCCN(C1)c1[nH]ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C18H19F2N7OS/c19-10-4-1-5-11(20)13(10)18-25-14(15(22)29-18)17(28)24-12-7-23-26-16(12)27-6-2-3-9(21)8-27/h1,4-5,7,9H,2-3,6,8,21-22H2,(H,23,26)(H,24,28)/t9-/m0/s1
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55.1 -41.4n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119392
PNG
(US8669361, 121 | US9573943, Example 121)
Show SMILES Cn1ncc(NC(=O)c2nc(Br)cnc2N)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C14H19BrN8O/c1-22-14(23-4-2-3-8(16)7-23)9(5-19-22)20-13(24)11-12(17)18-6-10(15)21-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,18)(H,20,24)/t8-/m0/s1
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68.1 -40.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119380
PNG
(US8669361, 102 | US9573943, Example 102)
Show SMILES Cn1cc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cn1
Show InChI InChI=1S/C14H11F2N5OS/c1-21-6-7(5-18-21)19-13(22)11-12(17)23-14(20-11)10-8(15)3-2-4-9(10)16/h2-6H,17H2,1H3,(H,19,22)
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110 -39.7n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119407
PNG
(US8669361, 364 | US9573943, Example 364)
Show SMILES CCn1ncc(NC(=O)c2nc(sc2N)-c2ccccc2F)c1N1CCC[C@@H](N)CC1
Show InChI InChI=1S/C21H26FN7OS/c1-2-29-21(28-10-5-6-13(23)9-11-28)16(12-25-29)26-19(30)17-18(24)31-20(27-17)14-7-3-4-8-15(14)22/h3-4,7-8,12-13H,2,5-6,9-11,23-24H2,1H3,(H,26,30)/t13-/m1/s1
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124 -39.4n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM119394
PNG
(US8669361, 123 | US9573943, Example 123)
Show SMILES Cn1ncc(NC(=O)c2nc(Cl)cnc2N)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C14H19ClN8O/c1-22-14(23-4-2-3-8(16)7-23)9(5-19-22)20-13(24)11-12(17)18-6-10(15)21-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,18)(H,20,24)/t8-/m0/s1
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137 -39.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119382
PNG
(US8669361, 105 | US9573943, Example 105)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1NCC1CCNCC1
Show InChI InChI=1S/C20H23F2N7OS/c1-29-18(25-9-11-5-7-24-8-6-11)14(10-26-29)27-19(30)16-17(23)31-20(28-16)15-12(21)3-2-4-13(15)22/h2-4,10-11,24-25H,5-9,23H2,1H3,(H,27,30)
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148 -39.0n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119392
PNG
(US8669361, 121 | US9573943, Example 121)
Show SMILES Cn1ncc(NC(=O)c2nc(Br)cnc2N)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C14H19BrN8O/c1-22-14(23-4-2-3-8(16)7-23)9(5-19-22)20-13(24)11-12(17)18-6-10(15)21-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,18)(H,20,24)/t8-/m0/s1
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154 -38.9n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119404
PNG
(US8669361, 263 | US9573943, Example 263)
Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CCNCC1
Show InChI InChI=1S/C19H20F2N6OS/c1-27-16(10-5-7-23-8-6-10)13(9-24-27)25-18(28)15-17(22)29-19(26-15)14-11(20)3-2-4-12(14)21/h2-4,9-10,23H,5-8,22H2,1H3,(H,25,28)
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185 -38.4n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119402
PNG
(US8669361, 231 | US9573943, Example 231)
Show SMILES CN1CCC(CC1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C20H22F2N6OS/c1-27-8-6-11(7-9-27)17-14(10-24-28(17)2)25-19(29)16-18(23)30-20(26-16)15-12(21)4-3-5-13(15)22/h3-5,10-11H,6-9,23H2,1-2H3,(H,25,29)
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201 -38.2n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM119394
PNG
(US8669361, 123 | US9573943, Example 123)
Show SMILES Cn1ncc(NC(=O)c2nc(Cl)cnc2N)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C14H19ClN8O/c1-22-14(23-4-2-3-8(16)7-23)9(5-19-22)20-13(24)11-12(17)18-6-10(15)21-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,18)(H,20,24)/t8-/m0/s1
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215 -38.1n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119401
PNG
(US8669361, 220 | US9573943, Example 220)
Show SMILES Cn1ncc(NC(=O)c2cncc(n2)-c2ccccc2F)c1N1CCC[C@H](N)CC1
Show InChI InChI=1S/C21H24FN7O/c1-28-21(29-9-4-5-14(23)8-10-29)19(13-25-28)27-20(30)18-12-24-11-17(26-18)15-6-2-3-7-16(15)22/h2-3,6-7,11-14H,4-5,8-10,23H2,1H3,(H,27,30)/t14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

US Patent
581 -35.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM119394
PNG
(US8669361, 123 | US9573943, Example 123)
Show SMILES Cn1ncc(NC(=O)c2nc(Cl)cnc2N)c1N1CCC[C@H](N)C1
Show InChI InChI=1S/C14H19ClN8O/c1-22-14(23-4-2-3-8(16)7-23)9(5-19-22)20-13(24)11-12(17)18-6-10(15)21-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,18)(H,20,24)/t8-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
587 -35.6n/an/an/an/an/a7.225



Genentech, Inc.

US Patent


Assay Description
PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...


US Patent US9573943 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%