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Patent code US9573957

Compile Data Set for Download or QSAR
Found 151 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289984
PNG
(2-Methyl-8-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-ylox...)
Show SMILES CN1CCC2(CCN(Cc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)CC2)C1=O
Show InChI InChI=1S/C26H27N5O3/c1-30-11-7-26(25(30)32)8-12-31(13-9-26)16-19-17-33-23-14-20(3-4-21(19)23)34-24-5-2-18(15-27-24)22-6-10-28-29-22/h2-6,10,14-15,17H,7-9,11-13,16H2,1H3,(H,28,29)
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n/an/a 0.220n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289920
PNG
(Preparation of 2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-...)
Show SMILES COCC(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C27H28N6O3/c1-35-17-27(34)32-15-21-5-6-22(16-32)33(21)14-20-4-2-18-12-23(7-8-24(18)30-20)36-26-9-3-19(13-28-26)25-10-11-29-31-25/h2-4,7-13,21-22H,5-6,14-17H2,1H3,(H,29,31)
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n/an/a 0.330n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289869
PNG
(N-((R)-1-{6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]...)
Show SMILES CC(=O)N[C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C25H25N5O2/c1-17(31)28-22-9-11-30(16-22)15-18-2-3-20-13-23(6-4-19(20)12-18)32-25-7-5-21(14-26-25)24-8-10-27-29-24/h2-8,10,12-14,22H,9,11,15-16H2,1H3,(H,27,29)(H,28,31)/t22-/m1/s1
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n/an/a 0.340n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289983
PNG
((S)-3-Hydroxy-1-(1-{6-[5-(2H- pyrazol-3-yl)-pyridi...)
Show SMILES O[C@H]1CCN(C2CCN(Cc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)CC2)C1=O
Show InChI InChI=1S/C26H27N5O4/c32-23-8-12-31(26(23)33)19-6-10-30(11-7-19)15-18-16-34-24-13-20(2-3-21(18)24)35-25-4-1-17(14-27-25)22-5-9-28-29-22/h1-5,9,13-14,16,19,23,32H,6-8,10-12,15H2,(H,28,29)/t23-/m0/s1
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n/an/a 0.360n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289980
PNG
(N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-ben...)
Show SMILES CC(=O)NCC1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C25H27N5O3/c1-17(31)26-13-18-7-10-30(11-8-18)15-20-16-32-24-12-21(3-4-22(20)24)33-25-5-2-19(14-27-25)23-6-9-28-29-23/h2-6,9,12,14,16,18H,7-8,10-11,13,15H2,1H3,(H,26,31)(H,28,29)
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n/an/a 0.380n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289864
PNG
(2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-...)
Show SMILES OCC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H25N5O3/c31-17-25(32)30-11-9-29(10-12-30)16-18-1-2-20-14-22(5-3-19(20)13-18)33-24-6-4-21(15-26-24)23-7-8-27-28-23/h1-8,13-15,31H,9-12,16-17H2,(H,27,28)
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n/an/a 0.400n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289987
PNG
(2-Hydroxy-N-methyl-N-((R)-1-{6- [5-(2H-pyrazol-3-y...)
Show SMILES CN([C@@H]1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)C1)C(=O)CO
Show InChI InChI=1S/C24H25N5O4/c1-28(24(31)14-30)18-7-9-29(13-18)12-17-15-32-22-10-19(3-4-20(17)22)33-23-5-2-16(11-25-23)21-6-8-26-27-21/h2-6,8,10-11,15,18,30H,7,9,12-14H2,1H3,(H,26,27)/t18-/m1/s1
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n/an/a 0.420n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289989
PNG
(2-Hydroxy-1-(7-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-...)
Show SMILES OCC(=O)N1CCC2(CCN(Cc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)C2)C1
Show InChI InChI=1S/C26H27N5O4/c32-14-25(33)31-10-7-26(17-31)6-9-30(16-26)13-19-15-34-23-11-20(2-3-21(19)23)35-24-4-1-18(12-27-24)22-5-8-28-29-22/h1-5,8,11-12,15,32H,6-7,9-10,13-14,16-17H2,(H,28,29)
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n/an/a 0.430n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289917
PNG
(Preparation of (S)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazo...)
Show SMILES C[C@H](O)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C27H28N6O3/c1-17(34)27(35)32-15-21-5-6-22(16-32)33(21)14-20-4-2-18-12-23(7-8-24(18)30-20)36-26-9-3-19(13-28-26)25-10-11-29-31-25/h2-4,7-13,17,21-22,34H,5-6,14-16H2,1H3,(H,29,31)/t17-,21?,22?/m0/s1
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n/an/a 0.430n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289897
PNG
(1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-n...)
Show SMILES CCC(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H26N6O2/c1-2-24(32)31-11-9-30(10-12-31)17-18-3-4-20-14-22(6-5-19(20)13-18)33-25-26-15-21(16-27-25)23-7-8-28-29-23/h3-8,13-16H,2,9-12,17H2,1H3,(H,28,29)
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n/an/a 0.430n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289858
PNG
(Preparation of 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2...)
Show SMILES OC1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C22H20N4O2/c27-19-13-26(14-19)12-15-1-2-17-10-20(5-3-16(17)9-15)28-22-6-4-18(11-23-22)21-7-8-24-25-21/h1-11,19,27H,12-14H2,(H,24,25)
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n/an/a 0.430n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289918
PNG
(2-Hydroxy-2-methyl-1-(8-{6-[5-(2H- pyrazol-3-yl)-p...)
Show SMILES CC(C)(O)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C28H30N6O3/c1-28(2,36)27(35)33-16-21-6-7-22(17-33)34(21)15-20-5-3-18-13-23(8-9-24(18)31-20)37-26-10-4-19(14-29-26)25-11-12-30-32-25/h3-5,8-14,21-22,36H,6-7,15-17H2,1-2H3,(H,30,32)
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n/an/a 0.450n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289859
PNG
(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2- yloxy]-naphth...)
Show SMILES NC(=O)C1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C23H21N5O2/c24-23(29)19-13-28(14-19)12-15-1-2-17-10-20(5-3-16(17)9-15)30-22-6-4-18(11-25-22)21-7-8-26-27-21/h1-11,19H,12-14H2,(H2,24,29)(H,26,27)
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n/an/a 0.460n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290023
PNG
(2-Methyl-3-oxo-3-(4-{6-[5-(2H-pyrazol- 3-yl)-pyrid...)
Show SMILES CC(C#N)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H25N7O2/c1-18(15-27)26(34)33-12-10-32(11-13-33)17-21-4-2-19-14-22(5-6-23(19)30-21)35-25-7-3-20(16-28-25)24-8-9-29-31-24/h2-9,14,16,18H,10-13,17H2,1H3,(H,29,31)
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n/an/a 0.470n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289932
PNG
(1-[1-(2-{6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]-...)
Show SMILES O=C1CCCN1C1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C27H29N5O3/c33-27-2-1-12-32(27)21-9-14-31(15-10-21)13-8-20-18-34-25-16-22(4-5-23(20)25)35-26-6-3-19(17-28-26)24-7-11-29-30-24/h3-7,11,16-18,21H,1-2,8-10,12-15H2,(H,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289867
PNG
(Preparation of 2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2...)
Show SMILES OC1CC2(C1)CN(Cc1ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c1)C2
Show InChI InChI=1S/C25H24N4O2/c30-21-11-25(12-21)15-29(16-25)14-17-1-2-19-10-22(5-3-18(19)9-17)31-24-6-4-20(13-26-24)23-7-8-27-28-23/h1-10,13,21,30H,11-12,14-16H2,(H,27,28)
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n/an/a 0.480n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289861
PNG
((1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-napht...)
Show SMILES OCC1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C23H22N4O2/c28-15-17-13-27(14-17)12-16-1-2-19-10-21(5-3-18(19)9-16)29-23-6-4-20(11-24-23)22-7-8-25-26-22/h1-11,17,28H,12-15H2,(H,25,26)
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n/an/a 0.480n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289976
PNG
(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2- yloxy]-benzof...)
Show SMILES CNC(=O)C1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C24H25N5O3/c1-25-24(30)16-7-10-29(11-8-16)14-18-15-31-22-12-19(3-4-20(18)22)32-23-5-2-17(13-26-23)21-6-9-27-28-21/h2-6,9,12-13,15-16H,7-8,10-11,14H2,1H3,(H,25,30)(H,27,28)
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n/an/a 0.490n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289860
PNG
(N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-nap...)
Show SMILES CC(=O)NC1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C24H23N5O2/c1-16(30)27-21-14-29(15-21)13-17-2-3-19-11-22(6-4-18(19)10-17)31-24-7-5-20(12-25-24)23-8-9-26-28-23/h2-12,21H,13-15H2,1H3,(H,26,28)(H,27,30)
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n/an/a 0.5n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289866
PNG
(2-Hydroxy-N-(1-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-...)
Show SMILES OCC(=O)NC1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H27N5O3/c32-17-25(33)29-22-8-11-31(12-9-22)16-18-1-2-20-14-23(5-3-19(20)13-18)34-26-6-4-21(15-27-26)24-7-10-28-30-24/h1-7,10,13-15,22,32H,8-9,11-12,16-17H2,(H,28,30)(H,29,33)
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n/an/a 0.5n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289868
PNG
(3-Methyl-1-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-ylox...)
Show SMILES CC1(O)CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C23H22N4O2/c1-23(28)14-27(15-23)13-16-2-3-18-11-20(6-4-17(18)10-16)29-22-7-5-19(12-24-22)21-8-9-25-26-21/h2-12,28H,13-15H2,1H3,(H,25,26)
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n/an/a 0.530n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289916
PNG
((1-Hydroxy-cyclopropyl)-(8-{6-[5- (2H-pyrazol-3-yl...)
Show SMILES OC1(CC1)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C28H28N6O3/c35-27(28(36)10-11-28)33-16-21-4-5-22(17-33)34(21)15-20-3-1-18-13-23(6-7-24(18)31-20)37-26-8-2-19(14-29-26)25-9-12-30-32-25/h1-3,6-9,12-14,21-22,36H,4-5,10-11,15-17H2,(H,30,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289919
PNG
(Preparation of (R)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazo...)
Show SMILES C[C@@H](O)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C27H28N6O3/c1-17(34)27(35)32-15-21-5-6-22(16-32)33(21)14-20-4-2-18-12-23(7-8-24(18)30-20)36-26-9-3-19(13-28-26)25-10-11-29-31-25/h2-4,7-13,17,21-22,34H,5-6,14-16H2,1H3,(H,29,31)/t17-,21?,22?/m1/s1
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n/an/a 0.540n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290002
PNG
(2-Methoxy-2-methyl-1-(4-{6- [5-(2H-pyrazol-3-yl)-p...)
Show SMILES COC(C)(C)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-27(2,35-3)26(34)33-14-12-32(13-15-33)18-21-6-4-19-16-22(7-8-23(19)30-21)36-25-9-5-20(17-28-25)24-10-11-29-31-24/h4-11,16-17H,12-15,18H2,1-3H3,(H,29,31)
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n/an/a 0.560n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289977
PNG
(N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-ben...)
Show SMILES CC(=O)NC1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C24H25N5O3/c1-16(30)27-19-7-10-29(11-8-19)14-18-15-31-23-12-20(3-4-21(18)23)32-24-5-2-17(13-25-24)22-6-9-26-28-22/h2-6,9,12-13,15,19H,7-8,10-11,14H2,1H3,(H,26,28)(H,27,30)
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n/an/a 0.560n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289988
PNG
(2-Hydroxy-N-methyl-N-((S)-1-{6- [5-(2H-pyrazol-3-y...)
Show SMILES CN([C@H]1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)C1)C(=O)CO
Show InChI InChI=1S/C24H25N5O4/c1-28(24(31)14-30)18-7-9-29(13-18)12-17-15-32-22-10-19(3-4-20(17)22)33-23-5-2-16(11-25-23)21-6-8-26-27-21/h2-6,8,10-11,15,18,30H,7,9,12-14H2,1H3,(H,26,27)/t18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290014
PNG
((R)-2-Methoxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES CO[C@H](C)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-18(34-2)26(33)32-13-11-31(12-14-32)17-21-5-3-19-15-22(6-7-23(19)29-21)35-25-8-4-20(16-27-25)24-9-10-28-30-24/h3-10,15-16,18H,11-14,17H2,1-2H3,(H,28,30)/t18-/m1/s1
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n/an/a 0.570n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289863
PNG
((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-na...)
Show SMILES O[C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C23H22N4O2/c28-20-8-10-27(15-20)14-16-1-2-18-12-21(5-3-17(18)11-16)29-23-6-4-19(13-24-23)22-7-9-25-26-22/h1-7,9,11-13,20,28H,8,10,14-15H2,(H,25,26)/t20-/m1/s1
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n/an/a 0.570n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289970
PNG
(Preparation of 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridi...)
Show SMILES CC(=O)N1CCCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C24H25N5O3/c1-17(30)29-10-2-9-28(11-12-29)15-19-16-31-23-13-20(4-5-21(19)23)32-24-6-3-18(14-25-24)22-7-8-26-27-22/h3-8,13-14,16H,2,9-12,15H2,1H3,(H,26,27)
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n/an/a 0.580n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289968
PNG
(1-(4-{6-[4-(2H-Pyrazol-3-yl)- phenoxy]-imidazo[1,2...)
Show SMILES CC(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C23H24N6O2/c1-17(30)28-12-10-27(11-13-28)14-19-15-29-16-21(6-7-23(29)25-19)31-20-4-2-18(3-5-20)22-8-9-24-26-22/h2-9,15-16H,10-14H2,1H3,(H,24,26)
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n/an/a 0.590n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289862
PNG
((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-na...)
Show SMILES O[C@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C23H22N4O2/c28-20-8-10-27(15-20)14-16-1-2-18-12-21(5-3-17(18)11-16)29-23-6-4-19(13-24-23)22-7-9-25-26-22/h1-7,9,11-13,20,28H,8,10,14-15H2,(H,25,26)/t20-/m0/s1
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n/an/a 0.600n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289878
PNG
(Preparation of 2-Hydroxy-1-[(R)-3-(methyl-{6-[5-(2...)
Show SMILES OCC(=O)N1CC[C@H](C1)NCc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1
Show InChI InChI=1S/C25H25N5O3/c31-16-25(32)30-10-8-21(15-30)26-13-17-1-2-19-12-22(5-3-18(19)11-17)33-24-6-4-20(14-27-24)23-7-9-28-29-23/h1-7,9,11-12,14,21,26,31H,8,10,13,15-16H2,(H,28,29)/t21-/m1/s1
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n/an/a 0.630n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289881
PNG
(((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-n...)
Show SMILES OC[C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C24H24N4O2/c29-16-18-8-10-28(15-18)14-17-1-2-20-12-22(5-3-19(20)11-17)30-24-6-4-21(13-25-24)23-7-9-26-27-23/h1-7,9,11-13,18,29H,8,10,14-16H2,(H,26,27)/t18-/m1/s1
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n/an/a 0.640n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289923
PNG
(1-(1-{(R)-6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]...)
Show SMILES O=C1CCCN1C1CCN(C[C@H]2Cc3ccc(Oc4ccc(cn4)-c4ccn[nH]4)cc3O2)CC1
Show InChI InChI=1S/C26H29N5O3/c32-26-2-1-11-31(26)20-8-12-30(13-9-20)17-22-14-18-3-5-21(15-24(18)33-22)34-25-6-4-19(16-27-25)23-7-10-28-29-23/h3-7,10,15-16,20,22H,1-2,8-9,11-14,17H2,(H,28,29)/t22-/m1/s1
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n/an/a 0.660n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289975
PNG
(2-Hydroxy-1-(7-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-...)
Show SMILES OCC(=O)N1CCC2(CCN(Cc3ccc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc4n3)C2)C1
Show InChI InChI=1S/C27H28N6O3/c34-16-26(35)33-12-9-27(18-33)8-11-32(17-27)15-21-3-1-19-13-22(4-5-23(19)30-21)36-25-6-2-20(14-28-25)24-7-10-29-31-24/h1-7,10,13-14,34H,8-9,11-12,15-18H2,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289956
PNG
(2-Methoxy-1-(4-{6-[4-(2H-pyrazol- 3-yl)-phenoxy]-i...)
Show SMILES COCC(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C24H26N6O3/c1-32-17-24(31)29-12-10-28(11-13-29)14-19-15-30-16-21(6-7-23(30)26-19)33-20-4-2-18(3-5-20)22-8-9-25-27-22/h2-9,15-16H,10-14,17H2,1H3,(H,25,27)
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n/an/a 0.660n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289913
PNG
((S)-2-Methoxy-1-(8-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES CO[C@@H](C)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C28H30N6O3/c1-18(36-2)28(35)33-16-22-6-7-23(17-33)34(22)15-21-5-3-19-13-24(8-9-25(19)31-21)37-27-10-4-20(14-29-27)26-11-12-30-32-26/h3-5,8-14,18,22-23H,6-7,15-17H2,1-2H3,(H,30,32)/t18-,22?,23?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289880
PNG
(2-Hydroxy-N-methyl-N-((R)-1-{6-[5- (2H-pyrazol-3-y...)
Show SMILES CN([C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1)C(=O)CO
Show InChI InChI=1S/C26H27N5O3/c1-30(26(33)17-32)22-9-11-31(16-22)15-18-2-3-20-13-23(6-4-19(20)12-18)34-25-7-5-21(14-27-25)24-8-10-28-29-24/h2-8,10,12-14,22,32H,9,11,15-17H2,1H3,(H,28,29)/t22-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289992
PNG
((S)-2-Methoxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES CO[C@@H](C)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-18(34-2)26(33)32-13-11-31(12-14-32)17-21-5-3-19-15-22(6-7-23(19)29-21)35-25-8-4-20(16-27-25)24-9-10-28-30-24/h3-10,15-16,18H,11-14,17H2,1-2H3,(H,28,30)/t18-/m0/s1
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n/an/a 0.670n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289985
PNG
(2-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-ben...)
Show SMILES O=C(CN1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1)N1CCCC1
Show InChI InChI=1S/C27H30N6O3/c34-27(33-9-1-2-10-33)18-32-13-11-31(12-14-32)17-21-19-35-25-15-22(4-5-23(21)25)36-26-6-3-20(16-28-26)24-7-8-29-30-24/h3-8,15-16,19H,1-2,9-14,17-18H2,(H,29,30)
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n/an/a 0.680n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289910
PNG
(Preparation of 3-Oxo-3-(8-{6-[5-(2H-pyrazol-3-yl)-...)
Show SMILES O=C(CC#N)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C27H25N7O2/c28-11-9-27(35)33-16-21-4-5-22(17-33)34(21)15-20-3-1-18-13-23(6-7-24(18)31-20)36-26-8-2-19(14-29-26)25-10-12-30-32-25/h1-3,6-8,10,12-14,21-22H,4-5,9,15-17H2,(H,30,32)
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n/an/a 0.690n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289981
PNG
(1-{4-[({6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]-b...)
Show SMILES CC(=O)N1CCC(CNCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C25H27N5O3/c1-17(31)30-10-7-18(8-11-30)13-26-14-20-16-32-24-12-21(3-4-22(20)24)33-25-5-2-19(15-27-25)23-6-9-28-29-23/h2-6,9,12,15-16,18,26H,7-8,10-11,13-14H2,1H3,(H,28,29)
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n/an/a 0.700n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289874
PNG
(2-(Methyl-{6-[5-(2H-pyrazol-3-yl)- pyridin-2-yloxy...)
Show SMILES CN(CCO)Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1
Show InChI InChI=1S/C22H22N4O2/c1-26(10-11-27)15-16-2-3-18-13-20(6-4-17(18)12-16)28-22-7-5-19(14-23-22)21-8-9-24-25-21/h2-9,12-14,27H,10-11,15H2,1H3,(H,24,25)
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n/an/a 0.700n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289982
PNG
(1-[4-({6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-be...)
Show SMILES CC(=O)N1CCC(CC1)NCc1coc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc12
Show InChI InChI=1S/C24H25N5O3/c1-16(30)29-10-7-19(8-11-29)25-14-18-15-31-23-12-20(3-4-21(18)23)32-24-5-2-17(13-26-24)22-6-9-27-28-22/h2-6,9,12-13,15,19,25H,7-8,10-11,14H2,1H3,(H,27,28)
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n/an/a 0.710n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289971
PNG
(Preparation of 2-Hydroxy-N-methyl-N-((R)-1-{6-[5-(...)
Show SMILES CN([C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)C1)C(=O)CO
Show InChI InChI=1S/C25H26N6O3/c1-30(25(33)16-32)20-9-11-31(15-20)14-19-4-2-17-12-21(5-6-22(17)28-19)34-24-7-3-18(13-26-24)23-8-10-27-29-23/h2-8,10,12-13,20,32H,9,11,14-16H2,1H3,(H,27,29)/t20-/m1/s1
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n/an/a 0.720n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289911
PNG
(2,2-Dimethyl-3-oxo-3-(8-{6-[5-(2H- pyrazol-3-yl)-p...)
Show SMILES CC(C)(C#N)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C29H29N7O2/c1-29(2,18-30)28(37)35-16-22-6-7-23(17-35)36(22)15-21-5-3-19-13-24(8-9-25(19)33-21)38-27-10-4-20(14-31-27)26-11-12-32-34-26/h3-5,8-14,22-23H,6-7,15-17H2,1-2H3,(H,32,34)
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n/an/a 0.730n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289933
PNG
((S)-3-Hydroxy-1-[1-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES O[C@H]1CCN(C2CCN(CCc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)CC2)C1=O
Show InChI InChI=1S/C27H29N5O4/c33-24-9-14-32(27(24)34)20-7-12-31(13-8-20)11-6-19-17-35-25-15-21(2-3-22(19)25)36-26-4-1-18(16-28-26)23-5-10-29-30-23/h1-5,10,15-17,20,24,33H,6-9,11-14H2,(H,29,30)/t24-/m0/s1
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n/an/a 0.730n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289929
PNG
(3-[1-(2-{6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]-...)
Show SMILES O=C1OCCN1C1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H29N5O4/c32-26-31(13-14-33-26)20-7-11-30(12-8-20)10-6-19-17-34-24-15-21(2-3-22(19)24)35-25-4-1-18(16-27-25)23-5-9-28-29-23/h1-5,9,15-16,19-20H,6-8,10-14,17H2,(H,28,29)
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n/an/a 0.75n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289875
PNG
((1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-napht...)
Show SMILES OCC1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H26N4O2/c30-17-18-8-11-29(12-9-18)16-19-1-2-21-14-23(5-3-20(21)13-19)31-25-6-4-22(15-26-25)24-7-10-27-28-24/h1-7,10,13-15,18,30H,8-9,11-12,16-17H2,(H,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289879
PNG
(2-Hydroxy-N-methyl-N-((S)-1-{6-[5- (2H-pyrazol-3-y...)
Show SMILES CN([C@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1)C(=O)CO
Show InChI InChI=1S/C26H27N5O3/c1-30(26(33)17-32)22-9-11-31(16-22)15-18-2-3-20-13-23(6-4-19(20)12-18)34-25-7-5-21(14-27-25)24-8-10-28-29-24/h2-8,10,12-14,22,32H,9,11,15-17H2,1H3,(H,28,29)/t22-/m0/s1
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n/an/a 0.760n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289876
PNG
(((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-n...)
Show SMILES OC[C@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C24H24N4O2/c29-16-18-8-10-28(15-18)14-17-1-2-20-12-22(5-3-19(20)11-17)30-24-6-4-21(13-25-24)23-7-9-26-27-23/h1-7,9,11-13,18,29H,8,10,14-16H2,(H,26,27)/t18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289922
PNG
((S)-3-Hydroxy-1-(1-{(R)-6-[5-(2H- pyrazol-3-yl)-py...)
Show SMILES O[C@H]1CCN(C2CCN(C[C@H]3Cc4ccc(Oc5ccc(cn5)-c5ccn[nH]5)cc4O3)CC2)C1=O
Show InChI InChI=1S/C26H29N5O4/c32-23-8-12-31(26(23)33)19-6-10-30(11-7-19)16-21-13-17-1-3-20(14-24(17)34-21)35-25-4-2-18(15-27-25)22-5-9-28-29-22/h1-5,9,14-15,19,21,23,32H,6-8,10-13,16H2,(H,28,29)/t21-,23+/m1/s1
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n/an/a 0.770n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289912
PNG
((R)-2-Methoxy-1-(8-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES CO[C@H](C)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C28H30N6O3/c1-18(36-2)28(35)33-16-22-6-7-23(17-33)34(22)15-21-5-3-19-13-24(8-9-25(19)31-21)37-27-10-4-20(14-29-27)26-11-12-30-32-26/h3-5,8-14,18,22-23H,6-7,15-17H2,1-2H3,(H,30,32)/t18-,22?,23?/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289951
PNG
(2-Hydroxy-1-(4-{6-[4-(2H-pyrazol- 3-yl)-phenoxy]-i...)
Show SMILES OCC(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4cnc[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C23H24N6O3/c30-15-23(31)28-9-7-27(8-10-28)12-18-13-29-14-20(5-6-22(29)26-18)32-19-3-1-17(2-4-19)21-11-24-16-25-21/h1-6,11,13-14,16,30H,7-10,12,15H2,(H,24,25)
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n/an/a 0.790n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289870
PNG
(N-((S)-1-{6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]...)
Show SMILES CC(=O)N[C@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C25H25N5O2/c1-17(31)28-22-9-11-30(16-22)15-18-2-3-20-13-23(6-4-19(20)12-18)32-25-7-5-21(14-26-25)24-8-10-27-29-24/h2-8,10,12-14,22H,9,11,15-16H2,1H3,(H,27,29)(H,28,31)/t22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289978
PNG
(N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-ben...)
Show SMILES CS(=O)(=O)NC1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C23H25N5O4S/c1-33(29,30)27-18-7-10-28(11-8-18)14-17-15-31-22-12-19(3-4-20(17)22)32-23-5-2-16(13-24-23)21-6-9-25-26-21/h2-6,9,12-13,15,18,27H,7-8,10-11,14H2,1H3,(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289894
PNG
(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naph...)
Show SMILES CN(C)C(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H27N7O2/c1-30(2)25(33)32-11-9-31(10-12-32)17-18-3-4-20-14-22(6-5-19(20)13-18)34-24-26-15-21(16-27-24)23-7-8-28-29-23/h3-8,13-16H,9-12,17H2,1-2H3,(H,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289940
PNG
((R)-2-Methoxy-1-(4-{6-[4-(2H-pyrazol- 3-yl)-phenox...)
Show SMILES CO[C@H](C)C(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C25H28N6O3/c1-18(33-2)25(32)30-13-11-29(12-14-30)15-20-16-31-17-22(7-8-24(31)27-20)34-21-5-3-19(4-6-21)23-9-10-26-28-23/h3-10,16-18H,11-15H2,1-2H3,(H,26,28)/t18-/m1/s1
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n/an/a 0.850n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289943
PNG
((S)-2-Hydroxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES C[C@H](O)C(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C25H27N5O4/c1-17(31)25(32)30-12-10-29(11-13-30)9-7-19-16-33-23-14-20(3-4-21(19)23)34-24-5-2-18(15-26-24)22-6-8-27-28-22/h2-6,8,14-17,31H,7,9-13H2,1H3,(H,27,28)/t17-/m0/s1
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n/an/a 0.860n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289865
PNG
(Preparation of (S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazo...)
Show SMILES O[C@H]1CCN(C2CCN(Cc3ccc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc4n3)CC2)C1=O
Show InChI InChI=1S/C27H28N6O3/c34-25-10-14-33(27(25)35)21-8-12-32(13-9-21)17-20-3-1-18-15-22(4-5-23(18)30-20)36-26-6-2-19(16-28-26)24-7-11-29-31-24/h1-7,11,15-16,21,25,34H,8-10,12-14,17H2,(H,29,31)/t25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290003
PNG
((S)-2-Hydroxy-1-(4-{6-[5-(2H- pyrazol-3-yl)-pyridi...)
Show SMILES C[C@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C25H26N6O3/c1-17(32)25(33)31-12-10-30(11-13-31)16-20-4-2-18-14-21(5-6-22(18)28-20)34-24-7-3-19(15-26-24)23-8-9-27-29-23/h2-9,14-15,17,32H,10-13,16H2,1H3,(H,27,29)/t17-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289972
PNG
(2-Hydroxy-N-methyl-N-((S)-1-{6- [5-(2H-pyrazol-3-y...)
Show SMILES CN([C@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)C1)C(=O)CO
Show InChI InChI=1S/C25H26N6O3/c1-30(25(33)16-32)20-9-11-31(15-20)14-19-4-2-17-12-21(5-6-22(17)28-19)34-24-7-3-18(13-26-24)23-8-10-27-29-23/h2-8,10,12-13,20,32H,9,11,14-16H2,1H3,(H,27,29)/t20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289990
PNG
(Preparation of 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridi...)
Show SMILES O=C(N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1)C1(CC1)C#N
Show InChI InChI=1S/C27H25N7O2/c28-18-27(8-9-27)26(35)34-13-11-33(12-14-34)17-21-3-1-19-15-22(4-5-23(19)31-21)36-25-6-2-20(16-29-25)24-7-10-30-32-24/h1-7,10,15-16H,8-9,11-14,17H2,(H,30,32)
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n/an/a 0.870n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289967
PNG
((R)-2-Hydroxy-1-(4-{6-[4-(2H- pyrazol-3-yl)-phenox...)
Show SMILES C[C@@H](O)C(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C24H26N6O3/c1-17(31)24(32)29-12-10-28(11-13-29)14-19-15-30-16-21(6-7-23(30)26-19)33-20-4-2-18(3-5-20)22-8-9-25-27-22/h2-9,15-17,31H,10-14H2,1H3,(H,25,27)/t17-/m1/s1
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n/an/a 0.870n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289935
PNG
((S)-2-Methoxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES CO[C@@H](C)C(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H29N5O4/c1-18(33-2)26(32)31-13-11-30(12-14-31)10-8-20-17-34-24-15-21(4-5-22(20)24)35-25-6-3-19(16-27-25)23-7-9-28-29-23/h3-7,9,15-18H,8,10-14H2,1-2H3,(H,28,29)/t18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289997
PNG
((R)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES C[C@@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C25H26N6O3/c1-17(32)25(33)31-12-10-30(11-13-31)16-20-4-2-18-14-21(5-6-22(18)28-20)34-24-7-3-19(15-26-24)23-8-9-27-29-23/h2-9,14-15,17,32H,10-13,16H2,1H3,(H,27,29)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289937
PNG
(2-Methoxy-1-[4-(2-{6-[5-(2H-pyrazol- 3-yl)-pyridin...)
Show SMILES COCC(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C25H27N5O4/c1-32-17-25(31)30-12-10-29(11-13-30)9-7-19-16-33-23-14-20(3-4-21(19)23)34-24-5-2-18(15-26-24)22-6-8-27-28-22/h2-6,8,14-16H,7,9-13,17H2,1H3,(H,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289882
PNG
(2-Hydroxy-1-[(S)-3-(methyl-{6-[5- (2H-pyrazol-3-yl...)
Show SMILES CN(Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1)[C@H]1CCN(C1)C(=O)CO
Show InChI InChI=1S/C26H27N5O3/c1-30(22-9-11-31(16-22)26(33)17-32)15-18-2-3-20-13-23(6-4-19(20)12-18)34-25-7-5-21(14-27-25)24-8-10-28-29-24/h2-8,10,12-14,22,32H,9,11,15-17H2,1H3,(H,28,29)/t22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289966
PNG
((1-Hydroxy-cyclopropyl)-[4-(2-{6- [5-(2H-pyrazol-3...)
Show SMILES OC1(CC1)C(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H27N5O4/c32-25(26(33)7-8-26)31-13-11-30(12-14-31)10-6-19-17-34-23-15-20(2-3-21(19)23)35-24-4-1-18(16-27-24)22-5-9-28-29-22/h1-5,9,15-17,33H,6-8,10-14H2,(H,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289938
PNG
((R)-2-Methoxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES CO[C@H](C)C(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H29N5O4/c1-18(33-2)26(32)31-13-11-30(12-14-31)10-8-20-17-34-24-15-21(4-5-22(20)24)35-25-6-3-19(16-27-25)23-7-9-28-29-23/h3-7,9,15-18H,8,10-14H2,1-2H3,(H,28,29)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289893
PNG
(3-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-n...)
Show SMILES O=C1OCCN1C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H26N6O3/c33-26-32(11-12-34-26)22-6-9-31(10-7-22)17-18-1-2-20-14-23(4-3-19(20)13-18)35-25-27-15-21(16-28-25)24-5-8-29-30-24/h1-5,8,13-16,22H,6-7,9-12,17H2,(H,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289902
PNG
(Preparation of 1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2...)
Show SMILES OC1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)C1
Show InChI InChI=1S/C21H19N5O2/c27-17-12-26(13-17)11-16-3-1-14-9-18(4-5-19(14)24-16)28-21-6-2-15(10-22-21)20-7-8-23-25-20/h1-10,17,27H,11-13H2,(H,23,25)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289973
PNG
(2-Hydroxy-1-[(R)-3-(methyl-{6- [5-(2H-pyrazol-3-yl...)
Show SMILES CN(Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1)[C@@H]1CCN(C1)C(=O)CO
Show InChI InChI=1S/C25H26N6O3/c1-30(20-9-11-31(15-20)25(33)16-32)14-19-4-2-17-12-21(5-6-22(17)28-19)34-24-7-3-18(13-26-24)23-8-10-27-29-23/h2-8,10,12-13,20,32H,9,11,14-16H2,1H3,(H,27,29)/t20-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289924
PNG
(1-(1-{(S)-6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]...)
Show SMILES O=C1CCCN1C1CCN(C[C@@H]2Cc3ccc(Oc4ccc(cn4)-c4ccn[nH]4)cc3O2)CC1
Show InChI InChI=1S/C26H29N5O3/c32-26-2-1-11-31(26)20-8-12-30(13-9-20)17-22-14-18-3-5-21(15-24(18)33-22)34-25-6-4-19(16-27-25)23-7-10-28-29-23/h3-7,10,15-16,20,22H,1-2,8-9,11-14,17H2,(H,28,29)/t22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289901
PNG
(2-Methyl-1-(4-{6-[5-(2H-pyrazol-3- yl)-pyrimidin-2...)
Show SMILES CC(C)C(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H28N6O2/c1-18(2)25(33)32-11-9-31(10-12-32)17-19-3-4-21-14-23(6-5-20(21)13-19)34-26-27-15-22(16-28-26)24-7-8-29-30-24/h3-8,13-16,18H,9-12,17H2,1-2H3,(H,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290000
PNG
((1-Hydroxy-cyclopropyl)-(4-{6- [5-(2H-pyrazol-3-yl...)
Show SMILES OC1(CC1)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H26N6O3/c33-25(26(34)8-9-26)32-13-11-31(12-14-32)17-20-3-1-18-15-21(4-5-22(18)29-20)35-24-6-2-19(16-27-24)23-7-10-28-30-23/h1-7,10,15-16,34H,8-9,11-14,17H2,(H,28,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289952
PNG
((S)-2-Hydroxy-1-(4-{6-[4-(2H- pyrazol-3-yl)-phenox...)
Show SMILES C[C@H](O)C(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C24H26N6O3/c1-17(31)24(32)29-12-10-28(11-13-29)14-19-15-30-16-21(6-7-23(30)26-19)33-20-4-2-18(3-5-20)22-8-9-25-27-22/h2-9,15-17,31H,10-14H2,1H3,(H,25,27)/t17-/m0/s1
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n/an/a 1n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289939
PNG
((S)-2-Methoxy-1-(4-{6-[4-(2H-pyrazol- 3-yl)-phenox...)
Show SMILES CO[C@@H](C)C(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4cnc[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C25H28N6O3/c1-18(33-2)25(32)30-11-9-29(10-12-30)14-20-15-31-16-22(7-8-24(31)28-20)34-21-5-3-19(4-6-21)23-13-26-17-27-23/h3-8,13,15-18H,9-12,14H2,1-2H3,(H,26,27)/t18-/m0/s1
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n/an/a 1n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289873
PNG
((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-na...)
Show SMILES O[C@@H]1CCCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C24H24N4O2/c29-21-2-1-11-28(16-21)15-17-3-4-19-13-22(7-5-18(19)12-17)30-24-8-6-20(14-25-24)23-9-10-26-27-23/h3-10,12-14,21,29H,1-2,11,15-16H2,(H,26,27)/t21-/m1/s1
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n/an/a 1n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289928
PNG
(Preparation of 1-[1-(2-{6-[5-(2H-Pyrazol-3-yl)-pyr...)
Show SMILES O=C1CCCN1C1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C27H31N5O3/c33-27-2-1-12-32(27)21-9-14-31(15-10-21)13-8-20-18-34-25-16-22(4-5-23(20)25)35-26-6-3-19(17-28-26)24-7-11-29-30-24/h3-7,11,16-17,20-21H,1-2,8-10,12-15,18H2,(H,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289892
PNG
(1-{3-[(Methyl-{6-[5-(2H-pyrazol-3- yl)-pyrimidin-2...)
Show SMILES CN(CC1CN(C1)C(C)=O)Cc1ccc2cc(Oc3ncc(cn3)-c3ccn[nH]3)ccc2c1
Show InChI InChI=1S/C25H26N6O2/c1-17(32)31-15-19(16-31)14-30(2)13-18-3-4-21-10-23(6-5-20(21)9-18)33-25-26-11-22(12-27-25)24-7-8-28-29-24/h3-12,19H,13-16H2,1-2H3,(H,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289965
PNG
((R)-2-Hydroxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES C[C@@H](O)C(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C25H27N5O4/c1-17(31)25(32)30-12-10-29(11-13-30)9-7-19-16-33-23-14-20(3-4-21(19)23)34-24-5-2-18(15-26-24)22-6-8-27-28-22/h2-6,8,14-17,31H,7,9-13H2,1H3,(H,27,28)/t17-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289898
PNG
(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naph...)
Show SMILES CN(C)C(=O)C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H28N6O2/c1-31(2)25(33)19-8-11-32(12-9-19)17-18-3-4-21-14-23(6-5-20(21)13-18)34-26-27-15-22(16-28-26)24-7-10-29-30-24/h3-7,10,13-16,19H,8-9,11-12,17H2,1-2H3,(H,29,30)
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n/an/a 1.20n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289953
PNG
((S)-2-Methoxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES CO[C@@H](C)C(=O)N1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H31N5O4/c1-18(33-2)26(32)31-13-11-30(12-14-31)10-8-20-17-34-24-15-21(4-5-22(20)24)35-25-6-3-19(16-27-25)23-7-9-28-29-23/h3-7,9,15-16,18,20H,8,10-14,17H2,1-2H3,(H,28,29)/t18-,20?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289921
PNG
(Preparation of (S)-3-Hydroxy-1-(1-{(S)-6-[5-(2H-py...)
Show SMILES O[C@H]1CCN(C2CCN(C[C@@H]3Cc4ccc(Oc5ccc(cn5)-c5ccn[nH]5)cc4O3)CC2)C1=O
Show InChI InChI=1S/C26H29N5O4/c32-23-8-12-31(26(23)33)19-6-10-30(11-7-19)16-21-13-17-1-3-20(14-24(17)34-21)35-25-4-2-18(15-27-25)22-5-9-28-29-22/h1-5,9,14-15,19,21,23,32H,6-8,10-13,16H2,(H,28,29)/t21-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289871
PNG
((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-na...)
Show SMILES O[C@H]1CCCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C24H24N4O2/c29-21-2-1-11-28(16-21)15-17-3-4-19-13-22(7-5-18(19)12-17)30-24-8-6-20(14-25-24)23-9-10-26-27-23/h3-10,12-14,21,29H,1-2,11,15-16H2,(H,26,27)/t21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289999
PNG
(2-Hydroxy-2-methyl-1-(4-{6- [5-(2H-pyrazol-3-yl)-p...)
Show SMILES CC(C)(O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-26(2,34)25(33)32-13-11-31(12-14-32)17-20-5-3-18-15-21(6-7-22(18)29-20)35-24-8-4-19(16-27-24)23-9-10-28-30-23/h3-10,15-16,34H,11-14,17H2,1-2H3,(H,28,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289969
PNG
((1-Hydroxy-cyclopropyl)-(4-{6- [4-(2H-pyrazol-3-yl...)
Show SMILES OC1(CC1)C(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C25H26N6O3/c32-24(25(33)8-9-25)30-13-11-29(12-14-30)15-19-16-31-17-21(5-6-23(31)27-19)34-20-3-1-18(2-4-20)22-7-10-26-28-22/h1-7,10,16-17,33H,8-9,11-15H2,(H,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290019
PNG
(2,2-Dimethyl-3-oxo-3-(4-{6-[5-(2H- pyrazol-3-yl)-p...)
Show SMILES CC(C)(C#N)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H27N7O2/c1-27(2,18-28)26(35)34-13-11-33(12-14-34)17-21-5-3-19-15-22(6-7-23(19)31-21)36-25-8-4-20(16-29-25)24-9-10-30-32-24/h3-10,15-16H,11-14,17H2,1-2H3,(H,30,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289944
PNG
((S)-2-Hydroxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES C[C@H](O)C(=O)N1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C25H29N5O4/c1-17(31)25(32)30-12-10-29(11-13-30)9-7-19-16-33-23-14-20(3-4-21(19)23)34-24-5-2-18(15-26-24)22-6-8-27-28-22/h2-6,8,14-15,17,19,31H,7,9-13,16H2,1H3,(H,27,28)/t17-,19?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289914
PNG
((8-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2- yloxy]-quino...)
Show SMILES O=C([C@H]1CCCO1)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C29H30N6O3/c36-29(27-2-1-13-37-27)34-17-22-6-7-23(18-34)35(22)16-21-5-3-19-14-24(8-9-25(19)32-21)38-28-10-4-20(15-30-28)26-11-12-31-33-26/h3-5,8-12,14-15,22-23,27H,1-2,6-7,13,16-18H2,(H,31,33)/t22?,23?,27-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289890
PNG
((S)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyrimi...)
Show SMILES C[C@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H26N6O3/c1-17(32)24(33)31-10-8-30(9-11-31)16-18-2-3-20-13-22(5-4-19(20)12-18)34-25-26-14-21(15-27-25)23-6-7-28-29-23/h2-7,12-15,17,32H,8-11,16H2,1H3,(H,28,29)/t17-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289946
PNG
(2-Hydroxy-2-methyl-1-[4-(2-{6-[5- (2H-pyrazol-3-yl...)
Show SMILES CC(C)(O)C(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H29N5O4/c1-26(2,33)25(32)31-13-11-30(12-14-31)10-8-19-17-34-23-15-20(4-5-21(19)23)35-24-6-3-18(16-27-24)22-7-9-28-29-22/h3-7,9,15-17,33H,8,10-14H2,1-2H3,(H,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289942
PNG
(2-Hydroxy-1-[4-(2-{6-[5-(2H-pyrazol- 3-yl)-pyridin...)
Show SMILES OCC(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C24H25N5O4/c30-15-24(31)29-11-9-28(10-12-29)8-6-18-16-32-22-13-19(2-3-20(18)22)33-23-4-1-17(14-25-23)21-5-7-26-27-21/h1-5,7,13-14,16,30H,6,8-12,15H2,(H,26,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289886
PNG
(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naph...)
Show SMILES NC(=O)C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C24H24N6O2/c25-23(31)17-6-9-30(10-7-17)15-16-1-2-19-12-21(4-3-18(19)11-16)32-24-26-13-20(14-27-24)22-5-8-28-29-22/h1-5,8,11-14,17H,6-7,9-10,15H2,(H2,25,31)(H,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289934
PNG
(1-Methanesulfonyl-4-(2-{6-[5-(2H- pyrazol-3-yl)-py...)
Show SMILES CS(=O)(=O)N1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C23H25N5O4S/c1-33(29,30)28-12-10-27(11-13-28)9-7-18-16-31-22-14-19(3-4-20(18)22)32-23-5-2-17(15-24-23)21-6-8-25-26-21/h2-6,8,14-16H,7,9-13H2,1H3,(H,25,26)
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n/an/a 1.40n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289891
PNG
(2-Hydroxy-N-methyl-N-(1-{6-[5-(2H- pyrazol-3-yl)-p...)
Show SMILES CN(C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1)C(=O)CO
Show InChI InChI=1S/C26H28N6O3/c1-31(25(34)17-33)22-7-10-32(11-8-22)16-18-2-3-20-13-23(5-4-19(20)12-18)35-26-27-14-21(15-28-26)24-6-9-29-30-24/h2-6,9,12-15,22,33H,7-8,10-11,16-17H2,1H3,(H,29,30)
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n/an/a 1.5n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289963
PNG
((1-Hydroxy-cyclopropyl)-[4-(2-{6- [5-(2H-pyrazol-3...)
Show SMILES OC1(CC1)C(=O)N1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H29N5O4/c32-25(26(33)7-8-26)31-13-11-30(12-14-31)10-6-19-17-34-23-15-20(2-3-21(19)23)35-24-4-1-18(16-27-24)22-5-9-28-29-22/h1-5,9,15-16,19,33H,6-8,10-14,17H2,(H,28,29)
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n/an/a 1.5n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289930
PNG
((S)-3-Hydroxy-1-[1-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES O[C@H]1CCN(C2CCN(CCC3COc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)CC2)C1=O
Show InChI InChI=1S/C27H31N5O4/c33-24-9-14-32(27(24)34)20-7-12-31(13-8-20)11-6-19-17-35-25-15-21(2-3-22(19)25)36-26-4-1-18(16-28-26)23-5-10-29-30-23/h1-5,10,15-16,19-20,24,33H,6-9,11-14,17H2,(H,29,30)/t19?,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289936
PNG
((R)-2-Methoxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES CO[C@H](C)C(=O)N1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H31N5O4/c1-18(33-2)26(32)31-13-11-30(12-14-31)10-8-20-17-34-24-15-21(4-5-22(20)24)35-25-6-3-19(16-27-25)23-7-9-28-29-23/h3-7,9,15-16,18,20H,8,10-14,17H2,1-2H3,(H,28,29)/t18-,20?/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289884
PNG
(1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-n...)
Show SMILES CC(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C24H24N6O2/c1-17(31)30-10-8-29(9-11-30)16-18-2-3-20-13-22(5-4-19(20)12-18)32-24-25-14-21(15-26-24)23-6-7-27-28-23/h2-7,12-15H,8-11,16H2,1H3,(H,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289926
PNG
(Preparation of 2-(4-Methanesulfonyl-piperazin-1-yl...)
Show SMILES CS(=O)(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C23H24N6O3S/c1-33(30,31)29-12-10-28(11-13-29)16-19-4-2-17-14-20(5-6-21(17)26-19)32-23-7-3-18(15-24-23)22-8-9-25-27-22/h2-9,14-15H,10-13,16H2,1H3,(H,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289931
PNG
(1-Methanesulfonyl-4-(2-{6-[5-(2H- pyrazol-3-yl)-py...)
Show SMILES CS(=O)(=O)N1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C23H27N5O4S/c1-33(29,30)28-12-10-27(11-13-28)9-7-18-16-31-22-14-19(3-4-20(18)22)32-23-5-2-17(15-24-23)21-6-8-25-26-21/h2-6,8,14-15,18H,7,9-13,16H2,1H3,(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289915
PNG
((8-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-quino...)
Show SMILES O=C([C@@H]1CCCO1)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C29H30N6O3/c36-29(27-2-1-13-37-27)34-17-22-6-7-23(18-34)35(22)16-21-5-3-19-14-24(8-9-25(19)32-21)38-28-10-4-20(15-30-28)26-11-12-31-33-26/h3-5,8-12,14-15,22-23,27H,1-2,6-7,13,16-18H2,(H,31,33)/t22?,23?,27-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290012
PNG
((1-Hydroxymethyl-cyclopropyl)-(4- {6-[5-(2H-pyrazo...)
Show SMILES OCC1(CC1)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H28N6O3/c34-18-27(8-9-27)26(35)33-13-11-32(12-14-33)17-21-3-1-19-15-22(4-5-23(19)30-21)36-25-6-2-20(16-28-25)24-7-10-29-31-24/h1-7,10,15-16,34H,8-9,11-14,17-18H2,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289887
PNG
(N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-n...)
Show SMILES CC(=O)NC1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H26N6O2/c1-17(32)29-22-7-10-31(11-8-22)16-18-2-3-20-13-23(5-4-19(20)12-18)33-25-26-14-21(15-27-25)24-6-9-28-30-24/h2-6,9,12-15,22H,7-8,10-11,16H2,1H3,(H,28,30)(H,29,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289900
PNG
(Cyclopropyl-(4-{6-[5-(2H-pyrazol-3- yl)-pyrimidin-...)
Show SMILES O=C(C1CC1)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H26N6O2/c33-25(19-3-4-19)32-11-9-31(10-12-32)17-18-1-2-21-14-23(6-5-20(21)13-18)34-26-27-15-22(16-28-26)24-7-8-29-30-24/h1-2,5-8,13-16,19H,3-4,9-12,17H2,(H,29,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289888
PNG
((S)-3-Hydroxy-1-(1-{6-[5-(2H-pyrazol- 3-yl)-pyrimi...)
Show SMILES O[C@H]1CCN(C2CCN(Cc3ccc4cc(Oc5ncc(cn5)-c5ccn[nH]5)ccc4c3)CC2)C1=O
Show InChI InChI=1S/C27H28N6O3/c34-25-8-12-33(26(25)35)22-6-10-32(11-7-22)17-18-1-2-20-14-23(4-3-19(20)13-18)36-27-28-15-21(16-29-27)24-5-9-30-31-24/h1-5,9,13-16,22,25,34H,6-8,10-12,17H2,(H,30,31)/t25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290017
PNG
((1-Hydroxy-cyclobutyl)-(4-{6- [5-(2H-pyrazol-3-yl)...)
Show SMILES OC1(CCC1)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H28N6O3/c34-26(27(35)9-1-10-27)33-14-12-32(13-15-33)18-21-4-2-19-16-22(5-6-23(19)30-21)36-25-7-3-20(17-28-25)24-8-11-29-31-24/h2-8,11,16-17,35H,1,9-10,12-15,18H2,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289907
PNG
(3-Methyl-1-{6-[5-(2H-pyrazol-3-yl)- pyrimidin-2-yl...)
Show SMILES CC1(O)CN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C22H21N5O2/c1-22(28)13-27(14-22)12-15-2-3-17-9-19(5-4-16(17)8-15)29-21-23-10-18(11-24-21)20-6-7-25-26-20/h2-11,28H,12-14H2,1H3,(H,25,26)
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n/an/a 1.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289986
PNG
(Preparation of 1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridi...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1coc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc12
Show InChI InChI=1S/C23H21N5O4/c1-15(29)27-8-10-28(11-9-27)23(30)19-14-31-21-12-17(3-4-18(19)21)32-22-5-2-16(13-24-22)20-6-7-25-26-20/h2-7,12-14H,8-11H2,1H3,(H,25,26)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289896
PNG
(1-(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-n...)
Show SMILES O=C1CCCN1C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C27H28N6O2/c34-26-2-1-11-33(26)23-8-12-32(13-9-23)18-19-3-4-21-15-24(6-5-20(21)14-19)35-27-28-16-22(17-29-27)25-7-10-30-31-25/h3-7,10,14-17,23H,1-2,8-9,11-13,18H2,(H,30,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289883
PNG
(Preparation of 2-Methoxy-1-(4-{6-[5-(2H-pyrazol-3-...)
Show SMILES COCC(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C25H26N6O3/c1-33-17-24(32)31-10-8-30(9-11-31)16-18-2-3-20-13-22(5-4-19(20)12-18)34-25-26-14-21(15-27-25)23-6-7-28-29-23/h2-7,12-15H,8-11,16-17H2,1H3,(H,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289903
PNG
(Preparation of 3-({6-[5-(2H-pyrazol-3-yl)-pyridin-...)
Show SMILES N#CCCNCc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C21H18N6O/c22-9-1-10-23-14-17-4-2-15-12-18(5-6-19(15)26-17)28-21-7-3-16(13-24-21)20-8-11-25-27-20/h2-8,11-13,23H,1,10,14H2,(H,25,27)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289974
PNG
(2-Hydroxy-1-[(S)-3-(methyl-{6- [5-(2H-pyrazol-3-yl...)
Show SMILES CN(Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1)[C@H]1CCN(C1)C(=O)CO
Show InChI InChI=1S/C25H26N6O3/c1-30(20-9-11-31(15-20)25(33)16-32)14-19-4-2-17-12-21(5-6-22(17)28-19)34-24-7-3-18(13-26-24)23-8-10-27-29-23/h2-8,10,12-13,20,32H,9,11,14-16H2,1H3,(H,27,29)/t20-/m0/s1
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n/an/a 2n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289909
PNG
(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naph...)
Show SMILES OC1CN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C21H19N5O2/c27-18-12-26(13-18)11-14-1-2-16-8-19(4-3-15(16)7-14)28-21-22-9-17(10-23-21)20-5-6-24-25-20/h1-10,18,27H,11-13H2,(H,24,25)
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n/an/a 2.20n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289899
PNG
(2-Hydroxy-2-methyl-1-(4-{6-[5-(2H- pyrazol-3-yl)-p...)
Show SMILES CC(C)(O)C(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-26(2,34)24(33)32-11-9-31(10-12-32)17-18-3-4-20-14-22(6-5-19(20)13-18)35-25-27-15-21(16-28-25)23-7-8-29-30-23/h3-8,13-16,34H,9-12,17H2,1-2H3,(H,29,30)
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n/an/a 2.20n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289964
PNG
((R)-2-Hydroxy-1-[4-(2-{6-[5-(2H- pyrazol-3-yl)-pyr...)
Show SMILES C[C@@H](O)C(=O)N1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C25H29N5O4/c1-17(31)25(32)30-12-10-29(11-13-30)9-7-19-16-33-23-14-20(3-4-21(19)23)34-24-5-2-18(15-26-24)22-6-8-27-28-22/h2-6,8,14-15,17,19,31H,7,9-13,16H2,1H3,(H,27,28)/t17-,19?/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289941
PNG
(2-Hydroxy-2-methyl-1-[4-(2-{6-[5- (2H-pyrazol-3-yl...)
Show SMILES CC(C)(O)C(=O)N1CCN(CCC2COc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1
Show InChI InChI=1S/C26H31N5O4/c1-26(2,33)25(32)31-13-11-30(12-14-31)10-8-19-17-34-23-15-20(4-5-21(19)23)35-24-6-3-18(16-27-24)22-7-9-28-29-22/h3-7,9,15-16,19,33H,8,10-14,17H2,1-2H3,(H,28,29)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289885
PNG
(1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-naph...)
Show SMILES OC1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C23H23N5O2/c29-20-6-9-28(10-7-20)15-16-1-2-18-12-21(4-3-17(18)11-16)30-23-24-13-19(14-25-23)22-5-8-26-27-22/h1-5,8,11-14,20,29H,6-7,9-10,15H2,(H,26,27)
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n/an/a 2.30n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290018
PNG
(2-Propoxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-...)
Show SMILES CCCOCC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-2-15-35-19-27(34)33-13-11-32(12-14-33)18-22-5-3-20-16-23(6-7-24(20)30-22)36-26-8-4-21(17-28-26)25-9-10-29-31-25/h3-10,16-17H,2,11-15,18-19H2,1H3,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290005
PNG
((4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-quino...)
Show SMILES O=C(C1CCOCC1)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C28H30N6O3/c35-28(20-8-15-36-16-9-20)34-13-11-33(12-14-34)19-23-3-1-21-17-24(4-5-25(21)31-23)37-27-6-2-22(18-29-27)26-7-10-30-32-26/h1-7,10,17-18,20H,8-9,11-16,19H2,(H,30,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290001
PNG
((S)-2-Hydroxy-1-(4-{6-[5-(2H- pyrazol-3-yl)-pyridi...)
Show SMILES CC[C@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-2-24(33)26(34)32-13-11-31(12-14-32)17-20-5-3-18-15-21(6-7-22(18)29-20)35-25-8-4-19(16-27-25)23-9-10-28-30-23/h3-10,15-16,24,33H,2,11-14,17H2,1H3,(H,28,30)/t24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289905
PNG
(Preparation of (R)-1-{6-[5-(2H-pyrazol-3-yl)-pyrim...)
Show SMILES O[C@@H]1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C22H21N5O2/c28-19-6-8-27(14-19)13-15-1-2-17-10-20(4-3-16(17)9-15)29-22-23-11-18(12-24-22)21-5-7-25-26-21/h1-5,7,9-12,19,28H,6,8,13-14H2,(H,25,26)/t19-/m1/s1
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n/an/a 2.40n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289906
PNG
((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-...)
Show SMILES O[C@H]1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)C1
Show InChI InChI=1S/C22H21N5O2/c28-19-6-8-27(14-19)13-15-1-2-17-10-20(4-3-16(17)9-15)29-22-23-11-18(12-24-22)21-5-7-25-26-21/h1-5,7,9-12,19,28H,6,8,13-14H2,(H,25,26)/t19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290011
PNG
((S)-2-Hydroxy-3-methyl-1-(4-{6- [5-(2H-pyrazol-3-y...)
Show SMILES CC(C)[C@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-18(2)26(34)27(35)33-13-11-32(12-14-33)17-21-5-3-19-15-22(6-7-23(19)30-21)36-25-8-4-20(16-28-25)24-9-10-29-31-24/h3-10,15-16,18,26,34H,11-14,17H2,1-2H3,(H,29,31)/t26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290016
PNG
(4-Methoxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-...)
Show SMILES COCCCC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-35-16-2-3-27(34)33-14-12-32(13-15-33)19-22-6-4-20-17-23(7-8-24(20)30-22)36-26-9-5-21(18-28-26)25-10-11-29-31-25/h4-11,17-18H,2-3,12-16,19H2,1H3,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290004
PNG
(2-Isopropoxy-1-(4-{6-[5-(2H- pyrazol-3-yl)-pyridin...)
Show SMILES CC(C)OCC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-19(2)35-18-27(34)33-13-11-32(12-14-33)17-22-5-3-20-15-23(6-7-24(20)30-22)36-26-8-4-21(16-28-26)25-9-10-29-31-25/h3-10,15-16,19H,11-14,17-18H2,1-2H3,(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289998
PNG
(2-Ethoxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-y...)
Show SMILES CCOCC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-2-34-18-26(33)32-13-11-31(12-14-32)17-21-5-3-19-15-22(6-7-23(19)29-21)35-25-8-4-20(16-27-25)24-9-10-28-30-24/h3-10,15-16H,2,11-14,17-18H2,1H3,(H,28,30)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290015
PNG
((4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-quino...)
Show SMILES O=C([C@@H]1CCOC1)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H28N6O3/c34-27(21-8-14-35-18-21)33-12-10-32(11-13-33)17-22-3-1-19-15-23(4-5-24(19)30-22)36-26-6-2-20(16-28-26)25-7-9-29-31-25/h1-7,9,15-16,21H,8,10-14,17-18H2,(H,29,31)/t21-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289904
PNG
((R)-3-({6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-q...)
Show SMILES CC[C@H](CC#N)NCc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1
Show InChI InChI=1S/C23H22N6O/c1-2-18(9-11-24)25-15-19-5-3-16-13-20(6-7-21(16)28-19)30-23-8-4-17(14-26-23)22-10-12-27-29-22/h3-8,10,12-14,18,25H,2,9,15H2,1H3,(H,27,29)/t18-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289895
PNG
(2,2-Dimethyl-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyrimid...)
Show SMILES CC(C)(C)C(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C27H30N6O2/c1-27(2,3)25(34)33-12-10-32(11-13-33)18-19-4-5-21-15-23(7-6-20(21)14-19)35-26-28-16-22(17-29-26)24-8-9-30-31-24/h4-9,14-17H,10-13,18H2,1-3H3,(H,30,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289927
PNG
(2-(4-Ethanesulfonyl-piperazin-1- ylmethyl)-6-[5-(2...)
Show SMILES CCS(=O)(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C24H26N6O3S/c1-2-34(31,32)30-13-11-29(12-14-30)17-20-5-3-18-15-21(6-7-22(18)27-20)33-24-8-4-19(16-25-24)23-9-10-26-28-23/h3-10,15-16H,2,11-14,17H2,1H3,(H,26,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290007
PNG
((4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-quino...)
Show SMILES O=C([C@H]1CCCO1)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H28N6O3/c34-27(25-2-1-15-35-25)33-13-11-32(12-14-33)18-21-5-3-19-16-22(6-7-23(19)30-21)36-26-8-4-20(17-28-26)24-9-10-29-31-24/h3-10,16-17,25H,1-2,11-15,18H2,(H,29,31)/t25-/m1/s1
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n/an/a 2.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290006
PNG
((4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-quino...)
Show SMILES O=C([C@@H]1CCCO1)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H28N6O3/c34-27(25-2-1-15-35-25)33-13-11-32(12-14-33)18-21-5-3-19-16-22(6-7-23(19)30-21)36-26-8-4-20(17-28-26)24-9-10-29-31-24/h3-10,16-17,25H,1-2,11-15,18H2,(H,29,31)/t25-/m0/s1
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n/an/a 2.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289908
PNG
(2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3- yl)-pyrimidin-...)
Show SMILES OCC(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1
Show InChI InChI=1S/C24H24N6O3/c31-16-23(32)30-9-7-29(8-10-30)15-17-1-2-19-12-21(4-3-18(19)11-17)33-24-25-13-20(14-26-24)22-5-6-27-28-22/h1-6,11-14,31H,7-10,15-16H2,(H,27,28)
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n/an/a 2.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290013
PNG
((3-Hydroxy-cyclobutyl)-(4-{6- [5-(2H-pyrazol-3-yl)...)
Show SMILES OC1CC(C1)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H28N6O3/c34-22-13-20(14-22)27(35)33-11-9-32(10-12-33)17-21-3-1-18-15-23(4-5-24(18)30-21)36-26-6-2-19(16-28-26)25-7-8-29-31-25/h1-8,15-16,20,22,34H,9-14,17H2,(H,29,31)
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n/an/a 3n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290008
PNG
((R)-2-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES CC[C@@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-2-24(33)26(34)32-13-11-31(12-14-32)17-20-5-3-18-15-21(6-7-22(18)29-20)35-25-8-4-19(16-27-25)23-9-10-28-30-23/h3-10,15-16,24,33H,2,11-14,17H2,1H3,(H,28,30)/t24-/m1/s1
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n/an/a 3.10n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290024
PNG
((3-Hydroxy-3-methyl-cyclobutyl)-(4- {6-[5-(2H-pyra...)
Show SMILES CC1(O)CC(C1)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C28H30N6O3/c1-28(36)15-21(16-28)27(35)34-12-10-33(11-13-34)18-22-4-2-19-14-23(5-6-24(19)31-22)37-26-7-3-20(17-29-26)25-8-9-30-32-25/h2-9,14,17,21,36H,10-13,15-16,18H2,1H3,(H,30,32)
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n/an/a 3.40n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290020
PNG
(1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-qui...)
Show SMILES O=C(N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1)C1(CCC1)C#N
Show InChI InChI=1S/C28H27N7O2/c29-19-28(9-1-10-28)27(36)35-14-12-34(13-15-35)18-22-4-2-20-16-23(5-6-24(20)32-22)37-26-7-3-21(17-30-26)25-8-11-31-33-25/h2-8,11,16-17H,1,9-10,12-15,18H2,(H,31,33)
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n/an/a 3.40n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289991
PNG
((S)-3-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES C[C@H](O)CC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-18(33)14-26(34)32-12-10-31(11-13-32)17-21-4-2-19-15-22(5-6-23(19)29-21)35-25-7-3-20(16-27-25)24-8-9-28-30-24/h2-9,15-16,18,33H,10-14,17H2,1H3,(H,28,30)/t18-/m0/s1
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n/an/a 3.70n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289996
PNG
(3-Hydroxy-3-methyl-1-(4-{6- [5-(2H-pyrazol-3-yl)-p...)
Show SMILES CC(C)(O)CC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-27(2,35)16-26(34)33-13-11-32(12-14-33)18-21-5-3-19-15-22(6-7-23(19)30-21)36-25-8-4-20(17-28-25)24-9-10-29-31-24/h3-10,15,17,35H,11-14,16,18H2,1-2H3,(H,29,31)
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n/an/a 3.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289925
PNG
(2-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-...)
Show SMILES OCC(=O)N1CCN(CC2Cc3ccc(Oc4ccc(cn4)-c4ccn[nH]4)cc3O2)CC1
Show InChI InChI=1S/C23H25N5O4/c29-15-23(30)28-9-7-27(8-10-28)14-19-11-16-1-3-18(12-21(16)31-19)32-22-4-2-17(13-24-22)20-5-6-25-26-20/h1-6,12-13,19,29H,7-11,14-15H2,(H,25,26)
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n/an/a 4.60n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289995
PNG
((R)-3-Hydroxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridi...)
Show SMILES C[C@@H](O)CC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C26H28N6O3/c1-18(33)14-26(34)32-12-10-31(11-13-32)17-21-4-2-19-15-22(5-6-23(19)29-21)35-25-7-3-20(16-27-25)24-8-9-28-30-24/h2-9,15-16,18,33H,10-14,17H2,1H3,(H,28,30)/t18-/m1/s1
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n/an/a 4.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290009
PNG
(3-Hydroxy-2,2-dimethyl-1-(4-{6- [5-(2H-pyrazol-3-y...)
Show SMILES CC(C)(CO)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-27(2,18-34)26(35)33-13-11-32(12-14-33)17-21-5-3-19-15-22(6-7-23(19)30-21)36-25-8-4-20(16-28-25)24-9-10-29-31-24/h3-10,15-16,34H,11-14,17-18H2,1-2H3,(H,29,31)
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n/an/a 5.40n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289994
PNG
((R)-2-Hydroxy-3-methyl-1-(4-{6- [5-(2H-pyrazol-3-y...)
Show SMILES CC(C)[C@@H](O)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C27H30N6O3/c1-18(2)26(34)27(35)33-13-11-32(12-14-33)17-21-5-3-19-15-22(6-7-23(19)30-21)36-25-8-4-20(16-28-25)24-9-10-29-31-24/h3-10,15-16,18,26,34H,11-14,17H2,1-2H3,(H,29,31)/t26-/m1/s1
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n/an/a 5.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290010
PNG
((3-Oxa-bicyclo[3.1.0]hex-6-yl)-(4- {6-[5-(2H-pyraz...)
Show SMILES O=C(C1C2COCC12)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C28H28N6O3/c35-28(27-22-16-36-17-23(22)27)34-11-9-33(10-12-34)15-20-3-1-18-13-21(4-5-24(18)31-20)37-26-6-2-19(14-29-26)25-7-8-30-32-25/h1-8,13-14,22-23,27H,9-12,15-17H2,(H,30,32)
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n/an/a 6n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290025
PNG
(((1R,2S)-2-Hydroxy-cyclopentyl)-(4- {6-[5-(2H-pyra...)
Show SMILES O[C@H]1CCC[C@H]1C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C28H30N6O3/c35-26-3-1-2-23(26)28(36)34-14-12-33(13-15-34)18-21-6-4-19-16-22(7-8-24(19)31-21)37-27-9-5-20(17-29-27)25-10-11-30-32-25/h4-11,16-17,23,26,35H,1-3,12-15,18H2,(H,30,32)/t23-,26+/m1/s1
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n/an/a 6.10n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290022
PNG
(4-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-qui...)
Show SMILES O=C(N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1)C1(CCOCC1)C#N
Show InChI InChI=1S/C29H29N7O3/c30-20-29(8-15-38-16-9-29)28(37)36-13-11-35(12-14-36)19-23-3-1-21-17-24(4-5-25(21)33-23)39-27-6-2-22(18-31-27)26-7-10-32-34-26/h1-7,10,17-18H,8-9,11-16,19H2,(H,32,34)
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n/an/a 7.90n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM289993
PNG
((1-Hydroxy-cyclopentyl)-(4-{6- [5-(2H-pyrazol-3-yl...)
Show SMILES OC1(CCCC1)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1
Show InChI InChI=1S/C28H30N6O3/c35-27(28(36)10-1-2-11-28)34-15-13-33(14-16-34)19-22-5-3-20-17-23(6-7-24(20)31-22)37-26-8-4-21(18-29-26)25-9-12-30-32-25/h3-9,12,17-18,36H,1-2,10-11,13-16,19H2,(H,30,32)
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n/an/a 8.60n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (human))
BDBM290021
PNG
(1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-qui...)
Show SMILES O=C(N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1)C1(CCCC1)C#N
Show InChI InChI=1S/C29H29N7O2/c30-20-29(10-1-2-11-29)28(37)36-15-13-35(14-16-36)19-23-5-3-21-17-24(6-7-25(21)33-23)38-27-8-4-22(18-31-27)26-9-12-32-34-26/h3-9,12,17-18H,1-2,10-11,13-16,19H2,(H,32,34)
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n/an/a 12n/an/an/an/a7.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...


US Patent US9573957 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%