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Patent code US9579320

Compile Data Set for Download or QSAR

Found 492 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290819
PNG
((S)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(1-...)
Show SMILES COC[C@H](CN)Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Show InChI InChI=1S/C17H21N9O2/c1-28-10-12(8-18)24-17-20-9-14(15(19)27)16(25-17)23-11-3-2-4-13(7-11)26-21-5-6-22-26/h2-7,9,12H,8,10,18H2,1H3,(H2,19,27)(H2,20,23,24,25)/t12-/m0/s1
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n/an/a<1n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290851
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(benzo[d][...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc3OCOc3c2)n1
Show InChI InChI=1S/C24H26N6O3/c25-18-6-1-2-7-19(18)29-24-27-12-17(22(26)31)23(30-24)28-16-5-3-4-14(10-16)15-8-9-20-21(11-15)33-13-32-20/h3-5,8-12,18-19H,1-2,6-7,13,25H2,(H2,26,31)(H2,27,28,29,30)/t18-,19+/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM291026
PNG
((S)-2-(2-amino-2-cyclopropylethylamino)-4-(1-methy...)
Show SMILES Cn1ccc2c(Nc3nc(NC[C@@H](N)C4CC4)ncc3C(N)=O)cccc12
Show InChI InChI=1S/C19H23N7O/c1-26-8-7-12-15(3-2-4-16(12)26)24-18-13(17(21)27)9-22-19(25-18)23-10-14(20)11-5-6-11/h2-4,7-9,11,14H,5-6,10,20H2,1H3,(H2,21,27)(H2,22,23,24,25)/t14-/m1/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM291028
PNG
((R)-2-(2-amino-3-ethoxypropylamino)-4-(1-ethyl-1H-...)
Show SMILES CCOC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3n(CC)ccc23)n1
Show InChI InChI=1S/C20H27N7O2/c1-3-27-9-8-14-16(6-5-7-17(14)27)25-19-15(18(22)28)11-24-20(26-19)23-10-13(21)12-29-4-2/h5-9,11,13H,3-4,10,12,21H2,1-2H3,(H2,22,28)(H2,23,24,25,26)/t13-/m1/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290647
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(thiazol-4...)
Show SMILES CCOC(=O)c1cnc(SC)nc1Nc1cccc(I)c1
Show InChI InChI=1S/C14H14IN3O2S/c1-3-20-13(19)11-8-16-14(21-2)18-12(11)17-10-6-4-5-9(15)7-10/h4-8H,3H2,1-2H3,(H,16,17,18)
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290670
PNG
(4-(3-(1H-pyrazol-5-yl)phenylamino)-2-((1R,2S)-2-am...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccn[nH]2)n1
Show InChI InChI=1S/C20H24N8O/c21-15-6-1-2-7-17(15)26-20-23-11-14(18(22)29)19(27-20)25-13-5-3-4-12(10-13)16-8-9-24-28-16/h3-5,8-11,15,17H,1-2,6-7,21H2,(H2,22,29)(H,24,28)(H2,23,25,26,27)/t15-,17+/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290737
PNG
(4-(1H-indol-6-ylamino)-2-((1R,2S)-2-aminocyclohexy...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3cc[nH]c3c2)n1
Show InChI InChI=1S/C19H23N7O/c20-14-3-1-2-4-15(14)25-19-23-10-13(17(21)27)18(26-19)24-12-6-5-11-7-8-22-16(11)9-12/h5-10,14-15,22H,1-4,20H2,(H2,21,27)(H2,23,24,25,26)/t14-,15+/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290763
PNG
(2-((1R,2S)-2- aminocyclohexylamino)- 4-(1-methyl-1...)
Show SMILES Cn1ncc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)ccc12
Show InChI InChI=1S/C19H24N8O/c1-27-16-7-6-12(8-11(16)9-23-27)24-18-13(17(21)28)10-22-19(26-18)25-15-5-3-2-4-14(15)20/h6-10,14-15H,2-5,20H2,1H3,(H2,21,28)(H2,22,24,25,26)/t14-,15+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290809
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(6-methoxynap...)
Show SMILES COc1ccc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)ccc2c1
Show InChI InChI=1S/C22H26N6O2/c1-30-16-9-7-13-10-15(8-6-14(13)11-16)26-21-17(20(24)29)12-25-22(28-21)27-19-5-3-2-4-18(19)23/h6-12,18-19H,2-5,23H2,1H3,(H2,24,29)(H2,25,26,27,28)/t18-,19+/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290819
PNG
((S)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(1-...)
Show SMILES COC[C@H](CN)Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Show InChI InChI=1S/C17H21N9O2/c1-28-10-12(8-18)24-17-20-9-14(15(19)27)16(25-17)23-11-3-2-4-13(7-11)26-21-5-6-22-26/h2-7,9,12H,8,10,18H2,1H3,(H2,19,27)(H2,20,23,24,25)/t12-/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290996
PNG
((R)-2-(2-amino-3-methylbutylamino)-4-(1-methyl-1H-...)
Show SMILES CC(C)[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3n(C)ccc23)n1
Show InChI InChI=1S/C19H25N7O/c1-11(2)14(20)10-23-19-22-9-13(17(21)27)18(25-19)24-15-5-4-6-16-12(15)7-8-26(16)3/h4-9,11,14H,10,20H2,1-3H3,(H2,21,27)(H2,22,23,24,25)/t14-/m1/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM291000
PNG
((R)-2-(2-amino-3-methoxypropylamino)-4-(2-methyl-2...)
Show SMILES COC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3nn(C)cc23)n1
Show InChI InChI=1S/C17H22N8O2/c1-25-8-12-13(4-3-5-14(12)24-25)22-16-11(15(19)26)7-21-17(23-16)20-6-10(18)9-27-2/h3-5,7-8,10H,6,9,18H2,1-2H3,(H2,19,26)(H2,20,21,22,23)/t10-/m1/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM291001
PNG
((R)-2-(2-amino-3-methoxypropylamino)-4-(2,3-dihydr...)
Show SMILES COC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3n4CCCc4cc23)n1
Show InChI InChI=1S/C20H25N7O2/c1-29-11-12(21)9-23-20-24-10-15(18(22)28)19(26-20)25-16-5-2-6-17-14(16)8-13-4-3-7-27(13)17/h2,5-6,8,10,12H,3-4,7,9,11,21H2,1H3,(H2,22,28)(H2,23,24,25,26)/t12-/m1/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290677
PNG
(4-(3-(1H-tetrazol-1-yl)phenylamino)-2-((1R,2S)-2-a...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2cnnn2)n1
Show InChI InChI=1S/C18H22N10O/c19-14-6-1-2-7-15(14)24-18-21-9-13(16(20)29)17(25-18)23-11-4-3-5-12(8-11)28-10-22-26-27-28/h3-5,8-10,14-15H,1-2,6-7,19H2,(H2,20,29)(H2,21,23,24,25)/t14-,15+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290727
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-methyl-5-(...)
Show SMILES Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)cc(c1)-n1nccn1
Show InChI InChI=1S/C20H25N9O/c1-12-8-13(10-14(9-12)29-24-6-7-25-29)26-19-15(18(22)30)11-23-20(28-19)27-17-5-3-2-4-16(17)21/h6-11,16-17H,2-5,21H2,1H3,(H2,22,30)(H2,23,26,27,28)/t16-,17+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290730
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(1-methyl-...)
Show SMILES Cn1ccc(n1)-c1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C21H26N8O/c1-29-10-9-17(28-29)13-5-4-6-14(11-13)25-20-15(19(23)30)12-24-21(27-20)26-18-8-3-2-7-16(18)22/h4-6,9-12,16,18H,2-3,7-8,22H2,1H3,(H2,23,30)(H2,24,25,26,27)/t16-,18+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290761
PNG
(2-((1R,2S)-2- aminocyclohexylamino)- 4-(quinolin-6...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3ncccc3c2)n1
Show InChI InChI=1S/C20H23N7O/c21-15-5-1-2-6-17(15)26-20-24-11-14(18(22)28)19(27-20)25-13-7-8-16-12(10-13)4-3-9-23-16/h3-4,7-11,15,17H,1-2,5-6,21H2,(H2,22,28)(H2,24,25,26,27)/t15-,17+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290813
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(6-(dimethylc...)
Show SMILES CN(C)C(=O)c1ccc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)ccc2c1
Show InChI InChI=1S/C24H29N7O2/c1-31(2)23(33)16-8-7-15-12-17(10-9-14(15)11-16)28-22-18(21(26)32)13-27-24(30-22)29-20-6-4-3-5-19(20)25/h7-13,19-20H,3-6,25H2,1-2H3,(H2,26,32)(H2,27,28,29,30)/t19-,20+/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290820
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(2-methyl-2H-...)
Show SMILES COC[C@H](CN)Nc1ncc(C(N)=O)c(Nc2cccc(C)c2)n1
Show InChI InChI=1S/C16H22N6O2/c1-10-4-3-5-11(6-10)20-15-13(14(18)23)8-19-16(22-15)21-12(7-17)9-24-2/h3-6,8,12H,7,9,17H2,1-2H3,(H2,18,23)(H2,19,20,21,22)/t12-/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290831
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(1-ethyl-1H-i...)
Show SMILES CCn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cccc12
Show InChI InChI=1S/C21H27N7O/c1-2-28-11-10-13-16(8-5-9-18(13)28)25-20-14(19(23)29)12-24-21(27-20)26-17-7-4-3-6-15(17)22/h5,8-12,15,17H,2-4,6-7,22H2,1H3,(H2,23,29)(H2,24,25,26,27)/t15-,17+/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290843
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(2,3-dihyd...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc3OCCOc3c2)n1
Show InChI InChI=1S/C25H28N6O3/c26-19-6-1-2-7-20(19)30-25-28-14-18(23(27)32)24(31-25)29-17-5-3-4-15(12-17)16-8-9-21-22(13-16)34-11-10-33-21/h3-5,8-9,12-14,19-20H,1-2,6-7,10-11,26H2,(H2,27,32)(H2,28,29,30,31)/t19-,20+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290995
PNG
((R)-2-(2-amino-3-methoxypropylamino)-4-(1-methyl-1...)
Show SMILES COC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3n(C)ccc23)n1
Show InChI InChI=1S/C18H23N7O2/c1-25-7-6-12-14(4-3-5-15(12)25)23-17-13(16(20)26)9-22-18(24-17)21-8-11(19)10-27-2/h3-7,9,11H,8,10,19H2,1-2H3,(H2,20,26)(H2,21,22,23,24)/t11-/m1/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290641
PNG
(4-(3-(1H-pyrazol-1-yl)phenylamino)-2-((1R,2S)-2-am...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2cccn2)n1
Show InChI InChI=1S/C20H24N8O/c21-16-7-1-2-8-17(16)26-20-23-12-15(18(22)29)19(27-20)25-13-5-3-6-14(11-13)28-10-4-9-24-28/h3-6,9-12,16-17H,1-2,7-8,21H2,(H2,22,29)(H2,23,25,26,27)/t16-,17+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290681
PNG
(4-(3-(1H-pyrrol-1-yl)phenylamino)-2-((1R,2S)-2-ami...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2cccc2)n1
Show InChI InChI=1S/C21H25N7O/c22-17-8-1-2-9-18(17)26-21-24-13-16(19(23)29)20(27-21)25-14-6-5-7-15(12-14)28-10-3-4-11-28/h3-7,10-13,17-18H,1-2,8-9,22H2,(H2,23,29)(H2,24,25,26,27)/t17-,18+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50400047
PNG
(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290725
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-methoxy-5-...)
Show SMILES COc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)cc(c1)-n1nccn1
Show InChI InChI=1S/C20H25N9O2/c1-31-14-9-12(8-13(10-14)29-24-6-7-25-29)26-19-15(18(22)30)11-23-20(28-19)27-17-5-3-2-4-16(17)21/h6-11,16-17H,2-5,21H2,1H3,(H2,22,30)(H2,23,26,27,28)/t16-,17+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290829
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(2,3-dihydro-...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc3n4CCCc4cc23)n1
Show InChI InChI=1S/C22H27N7O/c23-16-6-1-2-7-18(16)27-22-25-12-15(20(24)30)21(28-22)26-17-8-3-9-19-14(17)11-13-5-4-10-29(13)19/h3,8-9,11-12,16,18H,1-2,4-7,10,23H2,(H2,24,30)(H2,25,26,27,28)/t16-,18+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290762
PNG
(2-((1R,2S)-2- aminocyclohexylamino)- 4-(1-methyl-1...)
Show SMILES Cn1ncc2ccc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cc12
Show InChI InChI=1S/C19H24N8O/c1-27-16-8-12(7-6-11(16)9-23-27)24-18-13(17(21)28)10-22-19(26-18)25-15-5-3-2-4-14(15)20/h6-10,14-15H,2-5,20H2,1H3,(H2,21,28)(H2,22,24,25,26)/t14-,15+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290810
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(6-fluoronaph...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3cc(F)ccc3c2)n1
Show InChI InChI=1S/C21H23FN6O/c22-14-7-5-13-10-15(8-6-12(13)9-14)26-20-16(19(24)29)11-25-21(28-20)27-18-4-2-1-3-17(18)23/h5-11,17-18H,1-4,23H2,(H2,24,29)(H2,25,26,27,28)/t17-,18+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290811
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(6-carbamoyln...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3cc(ccc3c2)C(N)=O)n1
Show InChI InChI=1S/C22H25N7O2/c23-17-3-1-2-4-18(17)28-22-26-11-16(20(25)31)21(29-22)27-15-8-7-12-9-14(19(24)30)6-5-13(12)10-15/h5-11,17-18H,1-4,23H2,(H2,24,30)(H2,25,31)(H2,26,27,28,29)/t17-,18+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290818
PNG
((S)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(1-...)
Show SMILES Cn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cccc12
Show InChI InChI=1S/C20H25N7O/c1-27-10-9-12-15(7-4-8-17(12)27)24-19-13(18(22)28)11-23-20(26-19)25-16-6-3-2-5-14(16)21/h4,7-11,14,16H,2-3,5-6,21H2,1H3,(H2,22,28)(H2,23,24,25,26)/t14-,16+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290826
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(2-methyl-1H-...)
Show SMILES Cc1cc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)ncc3C(N)=O)cccc2[nH]1
Show InChI InChI=1S/C20H25N7O/c1-11-9-12-15(24-11)7-4-8-16(12)25-19-13(18(22)28)10-23-20(27-19)26-17-6-3-2-5-14(17)21/h4,7-10,14,17,24H,2-3,5-6,21H2,1H3,(H2,22,28)(H2,23,25,26,27)/t14-,17+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM291027
PNG
((S)-2-(2-aminobutylamino)-4-(1-methyl-1H-indol-4-y...)
Show SMILES CC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3n(C)ccc23)n1
Show InChI InChI=1S/C18H23N7O/c1-3-11(19)9-21-18-22-10-13(16(20)26)17(24-18)23-14-5-4-6-15-12(14)7-8-25(15)2/h4-8,10-11H,3,9,19H2,1-2H3,(H2,20,26)(H2,21,22,23,24)/t11-/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290627
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(pyridin-3...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2cccnc2)n1
Show InChI InChI=1S/C22H25N7O/c23-18-8-1-2-9-19(18)28-22-26-13-17(20(24)30)21(29-22)27-16-7-3-5-14(11-16)15-6-4-10-25-12-15/h3-7,10-13,18-19H,1-2,8-9,23H2,(H2,24,30)(H2,26,27,28,29)/t18-,19+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290649
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(thiazol-2...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2nccs2)n1
Show InChI InChI=1S/C20H23N7OS/c21-15-6-1-2-7-16(15)26-20-24-11-14(17(22)28)18(27-20)25-13-5-3-4-12(10-13)19-23-8-9-29-19/h3-5,8-11,15-16H,1-2,6-7,21H2,(H2,22,28)(H2,24,25,26,27)/t15-,16+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290692
PNG
(4-(3-(1H-imidazol-1-yl)phenylamino)-2-((1R,2S)-2-a...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2ccnc2)n1
Show InChI InChI=1S/C20H24N8O/c21-16-6-1-2-7-17(16)26-20-24-11-15(18(22)29)19(27-20)25-13-4-3-5-14(10-13)28-9-8-23-12-28/h3-5,8-12,16-17H,1-2,6-7,21H2,(H2,22,29)(H2,24,25,26,27)/t16-,17+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290696
PNG
(4-(3-(1H-1,2,3-triazol-1-yl)phenylamino)-2-((1R,2S...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2ccnn2)n1
Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)25-19-22-11-14(17(21)29)18(26-19)24-12-4-3-5-13(10-12)28-9-8-23-27-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,24,25,26)/t15-,16+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290721
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(4-(1-methyl-...)
Show SMILES Cn1cc(cn1)-c1ccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)cc1
Show InChI InChI=1S/C21H26N8O/c1-29-12-14(10-25-29)13-6-8-15(9-7-13)26-20-16(19(23)30)11-24-21(28-20)27-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H2,23,30)(H2,24,26,27,28)/t17-,18+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290738
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(quinolin-6-y...)
Show SMILES NC(=O)c1cnc(On2nnc3ccccc23)nc1Nc1ccc2ncccc2c1
Show InChI InChI=1S/C20H14N8O2/c21-18(29)14-11-23-20(30-28-17-6-2-1-5-16(17)26-27-28)25-19(14)24-13-7-8-15-12(10-13)4-3-9-22-15/h1-11H,(H2,21,29)(H,23,24,25)
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290768
PNG
(2-((1R,2S)-2- aminocyclohexylamino)- 4-(2-(cyclopr...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3nc(NC4CC4)ccc3c2)n1
Show InChI InChI=1S/C23H28N8O/c24-17-3-1-2-4-19(17)30-23-26-12-16(21(25)32)22(31-23)28-15-8-9-18-13(11-15)5-10-20(29-18)27-14-6-7-14/h5,8-12,14,17,19H,1-4,6-7,24H2,(H2,25,32)(H,27,29)(H2,26,28,30,31)/t17-,19+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290836
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(2,3-dihyd...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc3OCCc3c2)n1
Show InChI InChI=1S/C25H28N6O2/c26-20-6-1-2-7-21(20)30-25-28-14-19(23(27)32)24(31-25)29-18-5-3-4-15(13-18)16-8-9-22-17(12-16)10-11-33-22/h3-5,8-9,12-14,20-21H,1-2,6-7,10-11,26H2,(H2,27,32)(H2,28,29,30,31)/t20-,21+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290997
PNG
(2-((2R,3R)-2-amino-3-methoxylbutylamino)-4-(1-ethy...)
Show SMILES CCn1ccc2c(Nc3nc(NC[C@@H](N)[C@@H](C)OC)ncc3C(N)=O)cccc12
Show InChI InChI=1S/C20H27N7O2/c1-4-27-9-8-13-16(6-5-7-17(13)27)25-19-14(18(22)28)10-23-20(26-19)24-11-15(21)12(2)29-3/h5-10,12,15H,4,11,21H2,1-3H3,(H2,22,28)(H2,23,24,25,26)/t12-,15-/m1/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290999
PNG
((R)-2-(2-amino-3-ethoxypropylamino)-4-(1H-indol-4-...)
Show SMILES CCOC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3[nH]ccc23)n1
Show InChI InChI=1S/C18H23N7O2/c1-2-27-10-11(19)8-22-18-23-9-13(16(20)26)17(25-18)24-15-5-3-4-14-12(15)6-7-21-14/h3-7,9,11,21H,2,8,10,19H2,1H3,(H2,20,26)(H2,22,23,24,25)/t11-/m1/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM291019
PNG
((R)-2-(1-aminobutan-2-ylamino)-4-(3-(2H-1,2,3-tria...)
Show SMILES CC[C@H](CN)Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Show InChI InChI=1S/C17H21N9O/c1-2-11(9-18)24-17-20-10-14(15(19)27)16(25-17)23-12-4-3-5-13(8-12)26-21-6-7-22-26/h3-8,10-11H,2,9,18H2,1H3,(H2,19,27)(H2,20,23,24,25)/t11-/m1/s1
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n/an/a 5.5n/an/an/an/a7.525



Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM291029
PNG
((R)-2-(2-amino-3-methoxypropylamino)-4-(1H-indol-4...)
Show SMILES COC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3[nH]ccc23)n1
Show InChI InChI=1S/C17H21N7O2/c1-26-9-10(18)7-21-17-22-8-12(15(19)25)16(24-17)23-14-4-2-3-13-11(14)5-6-20-13/h2-6,8,10,20H,7,9,18H2,1H3,(H2,19,25)(H2,21,22,23,24)/t10-/m1/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290650
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(thiazol-5...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2cncs2)n1
Show InChI InChI=1S/C20H24N7OS/c21-15-6-1-2-7-16(15)26-20-24-9-14(18(22)28)19(27-20)25-13-5-3-4-12(8-13)17-10-23-11-29-17/h3-5,8-9,11,15-16H,1-2,6-7,10,21H2,(H2,22,28)(H2,24,25,26,27)/t15-,16+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290752
PNG
(2-((1R,2S)-2- aminocyclohexylamino)- 4-(3-oxo-3,4-...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3NC(=O)COc3c2)n1
Show InChI InChI=1S/C19H23N7O3/c20-12-3-1-2-4-13(12)25-19-22-8-11(17(21)28)18(26-19)23-10-5-6-14-15(7-10)29-9-16(27)24-14/h5-8,12-13H,1-4,9,20H2,(H2,21,28)(H,24,27)(H2,22,23,25,26)/t12-,13+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290838
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(4-fluorop...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-c2ccc(F)cc2)n1
Show InChI InChI=1S/C23H25FN6O/c24-16-10-8-14(9-11-16)15-4-3-5-17(12-15)28-22-18(21(26)31)13-27-23(30-22)29-20-7-2-1-6-19(20)25/h3-5,8-13,19-20H,1-2,6-7,25H2,(H2,26,31)(H2,27,28,29,30)/t19-,20+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290874
PNG
(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-vinylpheny...)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(C=C)c2)n1
Show InChI InChI=1S/C19H24N6O/c1-2-12-6-5-7-13(10-12)23-18-14(17(21)26)11-22-19(25-18)24-16-9-4-3-8-15(16)20/h2,5-7,10-11,15-16H,1,3-4,8-9,20H2,(H2,21,26)(H2,22,23,24,25)/t15-,16+/m0/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM290998
PNG
((R)-2-(2-amino-3-ethoxypropylamino)-4-(1-methyl-1H...)
Show SMILES CCOC[C@H](N)CNc1ncc(C(N)=O)c(Nc2cccc3n(C)ccc23)n1
Show InChI InChI=1S/C19H25N7O2/c1-3-28-11-12(20)9-22-19-23-10-14(17(21)27)18(25-19)24-15-5-4-6-16-13(15)7-8-26(16)2/h4-8,10,12H,3,9,11,20H2,1-2H3,(H2,21,27)(H2,22,23,24,25)/t12-/m1/s1
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Portola Pharmaceuticals, Inc.

US Patent


Assay Description
Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...


US Patent US9579320 (2017)

More data for this
Ligand-Target Pair
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