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Patent code US9580418

Compile Data Set for Download or QSAR
Found 156 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291182
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES COc1cc(F)c(c(F)c1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H26F2N6O2/c1-15-7-17(30)14-35(13-15)25-5-6-31-12-24(25)34-27(36)22-4-3-21-23(33-22)8-16(11-32-21)26-19(28)9-18(37-2)10-20(26)29/h3-6,8-12,15,17H,7,13-14,30H2,1-2H3,(H,34,36)/t15-,17+/m1/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291184
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C23H28N6O2/c1-13(2)15-8-19-17(26-9-15)4-5-18(27-19)23(31)28-20-10-25-7-6-21(20)29-11-14(3)22(30)16(24)12-29/h4-10,13-14,16,22,30H,11-12,24H2,1-3H3,(H,28,31)/t14-,16+,22+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291186
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C24H29N7O3/c1-15-13-31(14-17(25)23(15)32)22-4-5-26-12-21(22)29-24(33)19-3-2-18-20(28-19)10-16(11-27-18)30-6-8-34-9-7-30/h2-5,10-12,15,17,23,32H,6-9,13-14,25H2,1H3,(H,29,33)/t15-,17+,23+/m0/s1
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291187
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCc1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C23H27N5O2/c1-3-15-4-5-16-6-7-18(26-19(16)10-15)23(30)27-20-11-25-9-8-21(20)28-12-14(2)22(29)17(24)13-28/h4-11,14,17,22,29H,3,12-13,24H2,1-2H3,(H,27,30)/t14-,17+,22+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291187
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCc1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C23H27N5O2/c1-3-15-4-5-16-6-7-18(26-19(16)10-15)23(30)27-20-11-25-9-8-21(20)28-12-14(2)22(29)17(24)13-28/h4-11,14,17,22,29H,3,12-13,24H2,1-2H3,(H,27,30)/t14-,17+,22+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291191
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H30N6O3/c1-16-14-31(15-19(26)24(16)32)23-6-7-27-13-22(23)29-25(33)20-5-3-17-2-4-18(12-21(17)28-20)30-8-10-34-11-9-30/h2-7,12-13,16,19,24,32H,8-11,14-15,26H2,1H3,(H,29,33)/t16-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291196
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C27H31N7O2/c1-17-15-34(16-21(29)26(17)35)25-6-9-30-14-24(25)32-27(36)22-5-3-19-2-4-20(12-23(19)31-22)33-10-7-18(13-28)8-11-33/h2-6,9,12,14,17-18,21,26,35H,7-8,10-11,15-16,29H2,1H3,(H,32,36)/t17-,21+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291199
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1
Show InChI InChI=1S/C26H33N7O/c1-18-13-20(27)17-33(16-18)25-7-8-28-15-24(25)30-26(34)22-6-4-19-3-5-21(14-23(19)29-22)32-11-9-31(2)10-12-32/h3-8,14-15,18,20H,9-13,16-17,27H2,1-2H3,(H,30,34)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291201
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)c1ccncc1
Show InChI InChI=1S/C31H35N7O/c1-21-16-25(32)20-38(19-21)30-8-13-34-18-29(30)36-31(39)27-5-3-24-2-4-26(17-28(24)35-27)37-14-9-23(10-15-37)22-6-11-33-12-7-22/h2-8,11-13,17-18,21,23,25H,9-10,14-16,19-20,32H2,1H3,(H,36,39)/t21-,25+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291210
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCCC1
Show InChI InChI=1S/C25H30N6O2/c1-16-14-31(15-19(26)24(16)32)23-8-9-27-13-22(23)29-25(33)20-7-5-17-4-6-18(12-21(17)28-20)30-10-2-3-11-30/h4-9,12-13,16,19,24,32H,2-3,10-11,14-15,26H2,1H3,(H,29,33)/t16-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291216
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C28H29N7O3/c1-38-26-7-4-17(11-32-26)18-10-23-21(31-12-18)5-6-22(33-23)28(37)34-24-13-30-9-8-25(24)35-14-19(16-2-3-16)27(36)20(29)15-35/h4-13,16,19-20,27,36H,2-3,14-15,29H2,1H3,(H,34,37)/t19-,20-,27-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291219
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C26H28N8O2/c1-33-12-17(10-30-33)16-8-22-20(29-9-16)4-5-21(31-22)26(36)32-23-11-28-7-6-24(23)34-13-18(15-2-3-15)25(35)19(27)14-34/h4-12,15,18-19,25,35H,2-3,13-14,27H2,1H3,(H,32,36)/t18-,19-,25-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291224
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCn1cc(cn1)-c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C26H29N7O2/c1-3-33-14-19(11-29-33)18-5-4-17-6-7-21(30-22(17)10-18)26(35)31-23-12-28-9-8-24(23)32-13-16(2)25(34)20(27)15-32/h4-12,14,16,20,25,34H,3,13,15,27H2,1-2H3,(H,31,35)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291190
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)C1CCOCC1
Show InChI InChI=1S/C26H31N5O3/c1-16-14-31(15-20(27)25(16)32)24-6-9-28-13-23(24)30-26(33)21-5-4-18-2-3-19(12-22(18)29-21)17-7-10-34-11-8-17/h2-6,9,12-13,16-17,20,25,32H,7-8,10-11,14-15,27H2,1H3,(H,30,33)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291199
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1
Show InChI InChI=1S/C26H33N7O/c1-18-13-20(27)17-33(16-18)25-7-8-28-15-24(25)30-26(34)22-6-4-19-3-5-21(14-23(19)29-22)32-11-9-31(2)10-12-32/h3-8,14-15,18,20H,9-13,16-17,27H2,1-2H3,(H,30,34)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291200
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)c1ccncc1
Show InChI InChI=1S/C31H35N7O2/c1-20-18-38(19-25(32)30(20)39)29-8-13-34-17-28(29)36-31(40)26-5-3-23-2-4-24(16-27(23)35-26)37-14-9-22(10-15-37)21-6-11-33-12-7-21/h2-8,11-13,16-17,20,22,25,30,39H,9-10,14-15,18-19,32H2,1H3,(H,36,40)/t20-,25+,30+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291204
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COC1CCN(CC1)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H34N6O3/c1-17-15-33(16-21(28)26(17)34)25-7-10-29-14-24(25)31-27(35)22-6-4-18-3-5-19(13-23(18)30-22)32-11-8-20(36-2)9-12-32/h3-7,10,13-14,17,20-21,26,34H,8-9,11-12,15-16,28H2,1-2H3,(H,31,35)/t17-,21+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291211
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCCC1
Show InChI InChI=1S/C25H30N6O/c1-17-12-19(26)16-31(15-17)24-8-9-27-14-23(24)29-25(32)21-7-5-18-4-6-20(13-22(18)28-21)30-10-2-3-11-30/h4-9,13-14,17,19H,2-3,10-12,15-16,26H2,1H3,(H,29,32)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291218
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C27H30N8O2/c1-2-35-13-18(11-31-35)17-9-23-21(30-10-17)5-6-22(32-23)27(37)33-24-12-29-8-7-25(24)34-14-19(16-3-4-16)26(36)20(28)15-34/h5-13,16,19-20,26,36H,2-4,14-15,28H2,1H3,(H,33,37)/t19-,20-,26-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291220
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C31H39N7O3/c32-23-19-38(18-22(29(23)39)20-1-2-20)28-5-10-33-17-27(28)36-30(40)25-4-3-24-26(35-25)15-21(16-34-24)37-11-6-31(7-12-37)8-13-41-14-9-31/h3-5,10,15-17,20,22-23,29,39H,1-2,6-9,11-14,18-19,32H2,(H,36,40)/t22-,23-,29-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291231
PNG
(N-{4-[(3S,5R)-3-Amino-5-(trifluoromethyl)piperidin...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1ccccc1C#N)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)18-10-19(32)15-37(14-18)25-7-8-33-13-24(25)36-26(38)22-6-5-21-23(35-22)9-17(12-34-21)20-4-2-1-3-16(20)11-31/h1-9,12-13,18-19H,10,14-15,32H2,(H,36,38)/t18-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291185
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291193
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H30N6O2/c1-17-12-19(26)16-31(15-17)24-6-7-27-14-23(24)29-25(32)21-5-3-18-2-4-20(13-22(18)28-21)30-8-10-33-11-9-30/h2-7,13-14,17,19H,8-12,15-16,26H2,1H3,(H,29,32)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291194
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C30H38N6O3/c1-20-18-36(19-23(31)28(20)37)27-6-11-32-17-26(27)34-29(38)24-5-3-21-2-4-22(16-25(21)33-24)35-12-7-30(8-13-35)9-14-39-15-10-30/h2-6,11,16-17,20,23,28,37H,7-10,12-15,18-19,31H2,1H3,(H,34,38)/t20-,23+,28+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291195
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C30H38N6O2/c1-21-16-23(31)20-36(19-21)28-6-11-32-18-27(28)34-29(37)25-5-3-22-2-4-24(17-26(22)33-25)35-12-7-30(8-13-35)9-14-38-15-10-30/h2-6,11,17-18,21,23H,7-10,12-16,19-20,31H2,1H3,(H,34,37)/t21-,23+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291205
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES COC1CCN(CC1)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H34N6O2/c1-18-13-20(28)17-33(16-18)26-7-10-29-15-25(26)31-27(34)23-6-4-19-3-5-21(14-24(19)30-23)32-11-8-22(35-2)9-12-32/h3-7,10,14-15,18,20,22H,8-9,11-13,16-17,28H2,1-2H3,(H,31,34)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291223
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H27N7O2/c1-15-12-32(14-19(26)24(15)33)23-7-8-27-11-22(23)30-25(34)20-6-5-16-3-4-17(9-21(16)29-20)18-10-28-31(2)13-18/h3-11,13,15,19,24,33H,12,14,26H2,1-2H3,(H,30,34)/t15-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291223
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H27N7O2/c1-15-12-32(14-19(26)24(15)33)23-7-8-27-11-22(23)30-25(34)20-6-5-16-3-4-17(9-21(16)29-20)18-10-28-31(2)13-18/h3-11,13,15,19,24,33H,12,14,26H2,1-2H3,(H,30,34)/t15-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291225
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H28N6O3/c1-16-14-33(15-20(28)26(16)34)24-9-10-29-13-23(24)32-27(35)21-7-5-17-3-4-18(11-22(17)31-21)19-6-8-25(36-2)30-12-19/h3-13,16,20,26,34H,14-15,28H2,1-2H3,(H,32,35)/t16-,20+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291175
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CC(C)c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C23H28N6O/c1-14(2)16-9-20-18(26-10-16)4-5-19(27-20)23(30)28-21-11-25-7-6-22(21)29-12-15(3)8-17(24)13-29/h4-7,9-11,14-15,17H,8,12-13,24H2,1-3H3,(H,28,30)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291198
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1
Show InChI InChI=1S/C26H33N7O2/c1-17-15-33(16-20(27)25(17)34)24-7-8-28-14-23(24)30-26(35)21-6-4-18-3-5-19(13-22(18)29-21)32-11-9-31(2)10-12-32/h3-8,13-14,17,20,25,34H,9-12,15-16,27H2,1-2H3,(H,30,35)/t17-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291201
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)c1ccncc1
Show InChI InChI=1S/C31H35N7O/c1-21-16-25(32)20-38(19-21)30-8-13-34-18-29(30)36-31(39)27-5-3-24-2-4-26(17-28(24)35-27)37-14-9-23(10-15-37)22-6-11-33-12-7-22/h2-8,11-13,17-18,21,23,25H,9-10,14-16,19-20,32H2,1H3,(H,36,39)/t21-,25+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291202
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCN1CCN(CC1=O)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H33N7O3/c1-3-32-10-11-33(16-25(32)35)19-6-4-18-5-7-21(30-22(18)12-19)27(37)31-23-13-29-9-8-24(23)34-14-17(2)26(36)20(28)15-34/h4-9,12-13,17,20,26,36H,3,10-11,14-16,28H2,1-2H3,(H,31,37)/t17-,20+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291206
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H39N7O3/c1-20-18-37(19-24(31)29(20)38)28-6-9-32-17-27(28)34-30(39)25-5-3-21-2-4-23(16-26(21)33-25)35-10-7-22(8-11-35)36-12-14-40-15-13-36/h2-6,9,16-17,20,22,24,29,38H,7-8,10-15,18-19,31H2,1H3,(H,34,39)/t20-,24+,29+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291206
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H39N7O3/c1-20-18-37(19-24(31)29(20)38)28-6-9-32-17-27(28)34-30(39)25-5-3-21-2-4-23(16-26(21)33-25)35-10-7-22(8-11-35)36-12-14-40-15-13-36/h2-6,9,16-17,20,22,24,29,38H,7-8,10-15,18-19,31H2,1H3,(H,34,39)/t20-,24+,29+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291207
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H39N7O2/c1-21-16-23(31)20-37(19-21)29-6-9-32-18-28(29)34-30(38)26-5-3-22-2-4-25(17-27(22)33-26)35-10-7-24(8-11-35)36-12-14-39-15-13-36/h2-6,9,17-18,21,23-24H,7-8,10-16,19-20,31H2,1H3,(H,34,38)/t21-,23+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291208
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(C1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O2/c1-15-12-35(14-19(30)24(15)36)23-6-8-31-11-22(23)33-25(37)20-5-3-16-2-4-18(10-21(16)32-20)34-9-7-17(13-34)26(27,28)29/h2-6,8,10-11,15,17,19,24,36H,7,9,12-14,30H2,1H3,(H,33,37)/t15-,17?,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291209
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(C1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O/c1-16-10-19(30)15-35(13-16)24-6-8-31-12-23(24)33-25(36)21-5-3-17-2-4-20(11-22(17)32-21)34-9-7-18(14-34)26(27,28)29/h2-6,8,11-12,16,18-19H,7,9-10,13-15,30H2,1H3,(H,33,36)/t16-,18?,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291210
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCCC1
Show InChI InChI=1S/C25H30N6O2/c1-16-14-31(15-19(26)24(16)32)23-8-9-27-13-22(23)29-25(33)20-7-5-17-4-6-18(12-21(17)28-20)30-10-2-3-11-30/h4-9,12-13,16,19,24,32H,2-3,10-11,14-15,26H2,1H3,(H,29,33)/t16-,19+,24+/m0/s1
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Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291211
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCCC1
Show InChI InChI=1S/C25H30N6O/c1-17-12-19(26)16-31(15-17)24-8-9-27-14-23(24)29-25(32)21-7-5-18-4-6-20(13-22(18)28-21)30-10-2-3-11-30/h4-9,13-14,17,19H,2-3,10-12,15-16,26H2,1H3,(H,29,32)/t17-,19+/m1/s1
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Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1S/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291219
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C26H28N8O2/c1-33-12-17(10-30-33)16-8-22-20(29-9-16)4-5-21(31-22)26(36)32-23-11-28-7-6-24(23)34-13-18(15-2-3-15)25(35)19(27)14-34/h4-12,15,18-19,25,35H,2-3,13-14,27H2,1H3,(H,32,36)/t18-,19-,25-/m1/s1
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Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291222
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC2(CCCO2)CC1
Show InChI InChI=1S/C30H37N7O3/c31-22-18-37(17-21(28(22)38)19-2-3-19)27-6-10-32-16-26(27)35-29(39)24-5-4-23-25(34-24)14-20(15-33-23)36-11-8-30(9-12-36)7-1-13-40-30/h4-6,10,14-16,19,21-22,28,38H,1-3,7-9,11-13,17-18,31H2,(H,35,39)/t21-,22-,28-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291227
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cccnc1
Show InChI InChI=1S/C26H26N6O2/c1-16-14-32(15-20(27)25(16)33)24-8-10-29-13-23(24)31-26(34)21-7-6-17-4-5-18(11-22(17)30-21)19-3-2-9-28-12-19/h2-13,16,20,25,33H,14-15,27H2,1H3,(H,31,34)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291173
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H24F2N6O/c1-15-9-17(29)14-34(13-15)24-7-8-30-12-23(24)33-26(35)21-6-5-20-22(32-21)10-16(11-31-20)25-18(27)3-2-4-19(25)28/h2-8,10-12,15,17H,9,13-14,29H2,1H3,(H,33,35)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291175
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CC(C)c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C23H28N6O/c1-14(2)16-9-20-18(26-10-16)4-5-19(27-20)23(30)28-21-11-25-7-6-22(21)29-12-15(3)8-17(24)13-29/h4-7,9-11,14-15,17H,8,12-13,24H2,1-3H3,(H,28,30)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291176
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)C1CCOCC1
Show InChI InChI=1S/C25H30N6O2/c1-16-10-19(26)15-31(14-16)24-4-7-27-13-23(24)30-25(32)21-3-2-20-22(29-21)11-18(12-28-20)17-5-8-33-9-6-17/h2-4,7,11-13,16-17,19H,5-6,8-10,14-15,26H2,1H3,(H,30,32)/t16-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291182
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES COc1cc(F)c(c(F)c1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H26F2N6O2/c1-15-7-17(30)14-35(13-15)25-5-6-31-12-24(25)34-27(36)22-4-3-21-23(33-22)8-16(11-32-21)26-19(28)9-18(37-2)10-20(26)29/h3-6,8-12,15,17H,7,13-14,30H2,1-2H3,(H,34,36)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291193
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H30N6O2/c1-17-12-19(26)16-31(15-17)24-6-7-27-14-23(24)29-25(32)21-5-3-18-2-4-20(13-22(18)28-21)30-8-10-33-11-9-30/h2-7,13-14,17,19H,8-12,15-16,26H2,1H3,(H,29,32)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291195
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C30H38N6O2/c1-21-16-23(31)20-36(19-21)28-6-11-32-18-27(28)34-29(37)25-5-3-22-2-4-24(17-26(22)33-25)35-12-7-30(8-13-35)9-14-38-15-10-30/h2-6,11,17-18,21,23H,7-10,12-16,19-20,31H2,1H3,(H,34,37)/t21-,23+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291196
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C27H31N7O2/c1-17-15-34(16-21(29)26(17)35)25-6-9-30-14-24(25)32-27(36)22-5-3-19-2-4-20(12-23(19)31-22)33-10-7-18(13-28)8-11-33/h2-6,9,12,14,17-18,21,26,35H,7-8,10-11,15-16,29H2,1H3,(H,32,36)/t17-,21+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291202
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCN1CCN(CC1=O)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H33N7O3/c1-3-32-10-11-33(16-25(32)35)19-6-4-18-5-7-21(30-22(18)12-19)27(37)31-23-13-29-9-8-24(23)34-14-17(2)26(36)20(28)15-34/h4-9,12-13,17,20,26,36H,3,10-11,14-16,28H2,1-2H3,(H,31,37)/t17-,20+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291207
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H39N7O2/c1-21-16-23(31)20-37(19-21)29-6-9-32-18-28(29)34-30(38)26-5-3-22-2-4-25(17-27(22)33-26)35-10-7-24(8-11-35)36-12-14-39-15-13-36/h2-6,9,17-18,21,23-24H,7-8,10-16,19-20,31H2,1H3,(H,34,38)/t21-,23+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291209
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(C1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O/c1-16-10-19(30)15-35(13-16)24-6-8-31-12-23(24)33-25(36)21-5-3-17-2-4-20(11-22(17)32-21)34-9-7-18(14-34)26(27,28)29/h2-6,8,11-12,16,18-19H,7,9-10,13-15,30H2,1H3,(H,33,36)/t16-,18?,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291216
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C28H29N7O3/c1-38-26-7-4-17(11-32-26)18-10-23-21(31-12-18)5-6-22(33-23)28(37)34-24-13-30-9-8-25(24)35-14-19(16-2-3-16)27(36)20(29)15-35/h4-13,16,19-20,27,36H,2-3,14-15,29H2,1H3,(H,34,37)/t19-,20-,27-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291229
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccccc1C#N
Show InChI InChI=1S/C28H26N6O/c1-18-12-22(30)17-34(16-18)27-10-11-31-15-26(27)33-28(35)24-9-8-19-6-7-20(13-25(19)32-24)23-5-3-2-4-21(23)14-29/h2-11,13,15,18,22H,12,16-17,30H2,1H3,(H,33,35)/t18-,22+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291230
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(O)CC1
Show InChI InChI=1S/C26H32N6O2/c1-17-12-19(27)16-32(15-17)25-6-9-28-14-24(25)30-26(34)22-5-3-18-2-4-20(13-23(18)29-22)31-10-7-21(33)8-11-31/h2-6,9,13-14,17,19,21,33H,7-8,10-12,15-16,27H2,1H3,(H,30,34)/t17-,19+/m1/s1
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Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291173
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H24F2N6O/c1-15-9-17(29)14-34(13-15)24-7-8-30-12-23(24)33-26(35)21-6-5-20-22(32-21)10-16(11-31-20)25-18(27)3-2-4-19(25)28/h2-8,10-12,15,17H,9,13-14,29H2,1H3,(H,33,35)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291183
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C25H28N8O/c1-3-33-14-18(11-29-33)17-9-22-20(28-10-17)4-5-21(30-22)25(34)31-23-12-27-7-6-24(23)32-13-16(2)8-19(26)15-32/h4-7,9-12,14,16,19H,3,8,13,15,26H2,1-2H3,(H,31,34)/t16-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291184
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C23H28N6O2/c1-13(2)15-8-19-17(26-9-15)4-5-18(27-19)23(31)28-20-10-25-7-6-21(20)29-11-14(3)22(30)16(24)12-29/h4-10,13-14,16,22,30H,11-12,24H2,1-3H3,(H,28,31)/t14-,16+,22+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291186
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C24H29N7O3/c1-15-13-31(14-17(25)23(15)32)22-4-5-26-12-21(22)29-24(33)19-3-2-18-20(28-19)10-16(11-27-18)30-6-8-34-9-7-30/h2-5,10-12,15,17,23,32H,6-9,13-14,25H2,1H3,(H,29,33)/t15-,17+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291189
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C24H29N5O2/c1-14(2)17-5-4-16-6-7-19(27-20(16)10-17)24(31)28-21-11-26-9-8-22(21)29-12-15(3)23(30)18(25)13-29/h4-11,14-15,18,23,30H,12-13,25H2,1-3H3,(H,28,31)/t15-,18+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291194
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C30H38N6O3/c1-20-18-36(19-23(31)28(20)37)27-6-11-32-17-26(27)34-29(38)24-5-3-21-2-4-22(16-25(21)33-24)35-12-7-30(8-13-35)9-14-39-15-10-30/h2-6,11,16-17,20,23,28,37H,7-10,12-15,18-19,31H2,1H3,(H,34,38)/t20-,23+,28+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291198
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1
Show InChI InChI=1S/C26H33N7O2/c1-17-15-33(16-20(27)25(17)34)24-7-8-28-14-23(24)30-26(35)21-6-4-18-3-5-19(13-22(18)29-21)32-11-9-31(2)10-12-32/h3-8,13-14,17,20,25,34H,9-12,15-16,27H2,1-2H3,(H,30,35)/t17-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291200
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)c1ccncc1
Show InChI InChI=1S/C31H35N7O2/c1-20-18-38(19-25(32)30(20)39)29-8-13-34-17-28(29)36-31(40)26-5-3-23-2-4-24(16-27(23)35-26)37-14-9-22(10-15-37)21-6-11-33-12-7-21/h2-8,11-13,16-17,20,22,25,30,39H,9-10,14-15,18-19,32H2,1H3,(H,36,40)/t20-,25+,30+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291208
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(C1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O2/c1-15-12-35(14-19(30)24(15)36)23-6-8-31-11-22(23)33-25(37)20-5-3-16-2-4-18(10-21(16)32-20)34-9-7-17(13-34)26(27,28)29/h2-6,8,10-11,15,17,19,24,36H,7,9,12-14,30H2,1H3,(H,33,37)/t15-,17?,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291212
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1S/C26H32N6O2/c1-16-12-31(13-19(27)24(16)33)23-8-9-28-11-22(23)30-25(34)20-7-5-17-4-6-18(10-21(17)29-20)32-14-26(2,3)15-32/h4-11,16,19,24,33H,12-15,27H2,1-3H3,(H,30,34)/t16-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1S/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291215
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES COc1cc(F)c(c(F)c1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C29H28F2N6O3/c1-40-17-9-19(30)27(20(31)10-17)16-8-24-22(34-11-16)4-5-23(35-24)29(39)36-25-12-33-7-6-26(25)37-13-18(15-2-3-15)28(38)21(32)14-37/h4-12,15,18,21,28,38H,2-3,13-14,32H2,1H3,(H,36,39)/t18-,21-,28-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291217
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C31H34N8O3/c32-23-18-39(17-22(30(23)40)19-1-2-19)28-7-8-33-16-27(28)37-31(41)25-5-4-24-26(36-25)13-21(15-34-24)20-3-6-29(35-14-20)38-9-11-42-12-10-38/h3-8,13-16,19,22-23,30,40H,1-2,9-12,17-18,32H2,(H,37,41)/t22-,23-,30-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291217
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C31H34N8O3/c32-23-18-39(17-22(30(23)40)19-1-2-19)28-7-8-33-16-27(28)37-31(41)25-5-4-24-26(36-25)13-21(15-34-24)20-3-6-29(35-14-20)38-9-11-42-12-10-38/h3-8,13-16,19,22-23,30,40H,1-2,9-12,17-18,32H2,(H,37,41)/t22-,23-,30-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291225
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H28N6O3/c1-16-14-33(15-20(28)26(16)34)24-9-10-29-13-23(24)32-27(35)21-7-5-17-3-4-18(11-22(17)31-21)19-6-8-25(36-2)30-12-19/h3-13,16,20,26,34H,14-15,28H2,1-2H3,(H,32,35)/t16-,20+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291227
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cccnc1
Show InChI InChI=1S/C26H26N6O2/c1-16-14-32(15-20(27)25(16)33)24-8-10-29-13-23(24)31-26(34)21-7-6-17-4-5-18(11-22(17)30-21)19-3-2-9-28-12-19/h2-13,16,20,25,33H,14-15,27H2,1H3,(H,31,34)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291230
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(O)CC1
Show InChI InChI=1S/C26H32N6O2/c1-17-12-19(27)16-32(15-17)25-6-9-28-14-24(25)30-26(34)22-5-3-18-2-4-20(13-23(18)29-22)31-10-7-21(33)8-11-31/h2-6,9,13-14,17,19,21,33H,7-8,10-12,15-16,27H2,1H3,(H,30,34)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291232
PNG
(US9580418, Example 52)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccc(OC2CCOCC2)nc1
Show InChI InChI=1S/C31H34N6O4/c1-19-17-37(18-24(32)30(19)38)28-8-11-33-16-27(28)36-31(39)25-6-4-20-2-3-21(14-26(20)35-25)22-5-7-29(34-15-22)41-23-9-12-40-13-10-23/h2-8,11,14-16,19,23-24,30,38H,9-10,12-13,17-18,32H2,1H3,(H,36,39)/t19-,24+,30+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291183
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C25H28N8O/c1-3-33-14-18(11-29-33)17-9-22-20(28-10-17)4-5-21(30-22)25(34)31-23-12-27-7-6-24(23)32-13-16(2)8-19(26)15-32/h4-7,9-12,14,16,19H,3,8,13,15,26H2,1-2H3,(H,31,34)/t16-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291189
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C24H29N5O2/c1-14(2)17-5-4-16-6-7-19(27-20(16)10-17)24(31)28-21-11-26-9-8-22(21)29-12-15(3)23(30)18(25)13-29/h4-11,14-15,18,23,30H,12-13,25H2,1-3H3,(H,28,31)/t15-,18+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291197
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C27H31N7O/c1-18-12-21(29)17-34(16-18)26-6-9-30-15-25(26)32-27(35)23-5-3-20-2-4-22(13-24(20)31-23)33-10-7-19(14-28)8-11-33/h2-6,9,13,15,18-19,21H,7-8,10-12,16-17,29H2,1H3,(H,32,35)/t18-,21+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291203
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CCN1CCN(CC1=O)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N7O2/c1-3-32-10-11-33(17-26(32)35)21-6-4-19-5-7-22(30-23(19)13-21)27(36)31-24-14-29-9-8-25(24)34-15-18(2)12-20(28)16-34/h4-9,13-14,18,20H,3,10-12,15-17,28H2,1-2H3,(H,31,36)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291203
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CCN1CCN(CC1=O)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N7O2/c1-3-32-10-11-33(17-26(32)35)21-6-4-19-5-7-22(30-23(19)13-21)27(36)31-24-14-29-9-8-25(24)34-15-18(2)12-20(28)16-34/h4-9,13-14,18,20H,3,10-12,15-17,28H2,1-2H3,(H,31,36)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291205
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES COC1CCN(CC1)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H34N6O2/c1-18-13-20(28)17-33(16-18)26-7-10-29-15-25(26)31-27(34)23-6-4-19-3-5-21(14-24(19)30-23)32-11-8-22(35-2)9-12-32/h3-7,10,14-15,18,20,22H,8-9,11-13,16-17,28H2,1-2H3,(H,31,34)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291212
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1S/C26H32N6O2/c1-16-12-31(13-19(27)24(16)33)23-8-9-28-11-22(23)30-25(34)20-7-5-17-4-6-18(10-21(17)29-20)32-14-26(2,3)15-32/h4-11,16,19,24,33H,12-15,27H2,1-3H3,(H,30,34)/t16-,19+,24+/m0/s1
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Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291220
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C31H39N7O3/c32-23-19-38(18-22(29(23)39)20-1-2-20)28-5-10-33-17-27(28)36-30(40)25-4-3-24-26(35-25)15-21(16-34-24)37-11-6-31(7-12-37)8-13-41-14-9-31/h3-5,10,15-17,20,22-23,29,39H,1-2,6-9,11-14,18-19,32H2,(H,36,40)/t22-,23-,29-/m1/s1
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Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291222
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC2(CCCO2)CC1
Show InChI InChI=1S/C30H37N7O3/c31-22-18-37(17-21(28(22)38)19-2-3-19)27-6-10-32-16-26(27)35-29(39)24-5-4-23-25(34-24)14-20(15-33-23)36-11-8-30(9-12-36)7-1-13-40-30/h4-6,10,14-16,19,21-22,28,38H,1-3,7-9,11-13,17-18,31H2,(H,35,39)/t21-,22-,28-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291226
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C30H33N7O3/c1-19-17-37(18-23(31)29(19)38)27-8-9-32-16-26(27)35-30(39)24-6-4-20-2-3-21(14-25(20)34-24)22-5-7-28(33-15-22)36-10-12-40-13-11-36/h2-9,14-16,19,23,29,38H,10-13,17-18,31H2,1H3,(H,35,39)/t19-,23+,29+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291226
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C30H33N7O3/c1-19-17-37(18-23(31)29(19)38)27-8-9-32-16-26(27)35-30(39)24-6-4-20-2-3-21(14-25(20)34-24)22-5-7-28(33-15-22)36-10-12-40-13-11-36/h2-9,14-16,19,23,29,38H,10-13,17-18,31H2,1H3,(H,35,39)/t19-,23+,29+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291228
PNG
(N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H27N7O/c1-16-9-20(26)15-32(13-16)24-7-8-27-12-23(24)30-25(33)21-6-5-17-3-4-18(10-22(17)29-21)19-11-28-31(2)14-19/h3-8,10-12,14,16,20H,9,13,15,26H2,1-2H3,(H,30,33)/t16-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291229
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccccc1C#N
Show InChI InChI=1S/C28H26N6O/c1-18-12-22(30)17-34(16-18)27-10-11-31-15-26(27)33-28(35)24-9-8-19-6-7-20(13-25(19)32-24)23-5-3-2-4-21(23)14-29/h2-11,13,15,18,22H,12,16-17,30H2,1H3,(H,33,35)/t18-,22+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291231
PNG
(N-{4-[(3S,5R)-3-Amino-5-(trifluoromethyl)piperidin...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1ccccc1C#N)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)18-10-19(32)15-37(14-18)25-7-8-33-13-24(25)36-26(38)22-6-5-21-23(35-22)9-17(12-34-21)20-4-2-1-3-16(20)11-31/h1-9,12-13,18-19H,10,14-15,32H2,(H,36,38)/t18-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291232
PNG
(US9580418, Example 52)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccc(OC2CCOCC2)nc1
Show InChI InChI=1S/C31H34N6O4/c1-19-17-37(18-24(32)30(19)38)28-8-11-33-16-27(28)36-31(39)25-6-4-20-2-3-21(14-26(20)35-25)22-5-7-29(34-15-22)41-23-9-12-40-13-10-23/h2-8,11,14-16,19,23-24,30,38H,9-10,12-13,17-18,32H2,1H3,(H,36,39)/t19-,24+,30+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291176
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)C1CCOCC1
Show InChI InChI=1S/C25H30N6O2/c1-16-10-19(26)15-31(14-16)24-4-7-27-13-23(24)30-25(32)21-3-2-20-22(29-21)11-18(12-28-20)17-5-8-33-9-6-17/h2-4,7,11-13,16-17,19H,5-6,8-10,14-15,26H2,1H3,(H,30,32)/t16-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291185
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291190
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)C1CCOCC1
Show InChI InChI=1S/C26H31N5O3/c1-16-14-31(15-20(27)25(16)32)24-6-9-28-13-23(24)30-26(33)21-5-4-18-2-3-19(12-22(18)29-21)17-7-10-34-11-8-17/h2-6,9,12-13,16-17,20,25,32H,7-8,10-11,14-15,27H2,1H3,(H,30,33)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291191
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H30N6O3/c1-16-14-31(15-19(26)24(16)32)23-6-7-27-13-22(23)29-25(33)20-5-3-17-2-4-18(12-21(17)28-20)30-8-10-34-11-9-30/h2-7,12-13,16,19,24,32H,8-11,14-15,26H2,1H3,(H,29,33)/t16-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291197
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C27H31N7O/c1-18-12-21(29)17-34(16-18)26-6-9-30-15-25(26)32-27(35)23-5-3-20-2-4-22(13-24(20)31-23)33-10-7-19(14-28)8-11-33/h2-6,9,13,15,18-19,21H,7-8,10-12,16-17,29H2,1H3,(H,32,35)/t18-,21+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291204
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COC1CCN(CC1)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H34N6O3/c1-17-15-33(16-21(28)26(17)34)25-7-10-29-14-24(25)31-27(35)22-6-4-18-3-5-19(13-23(18)30-22)32-11-8-20(36-2)9-12-32/h3-7,10,13-14,17,20-21,26,34H,8-9,11-12,15-16,28H2,1-2H3,(H,31,35)/t17-,21+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291214
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC1
Show InChI InChI=1S/C24H28N6O/c1-16-11-18(25)15-30(14-16)23-7-8-26-13-22(23)28-24(31)20-6-4-17-3-5-19(12-21(17)27-20)29-9-2-10-29/h3-8,12-13,16,18H,2,9-11,14-15,25H2,1H3,(H,28,31)/t16-,18+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291214
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC1
Show InChI InChI=1S/C24H28N6O/c1-16-11-18(25)15-30(14-16)23-7-8-26-13-22(23)28-24(31)20-6-4-17-3-5-19(12-21(17)27-20)29-9-2-10-29/h3-8,12-13,16,18H,2,9-11,14-15,25H2,1H3,(H,28,31)/t16-,18+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291215
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES COc1cc(F)c(c(F)c1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C29H28F2N6O3/c1-40-17-9-19(30)27(20(31)10-17)16-8-24-22(34-11-16)4-5-23(35-24)29(39)36-25-12-33-7-6-26(25)37-13-18(15-2-3-15)28(38)21(32)14-37/h4-12,15,18,21,28,38H,2-3,13-14,32H2,1H3,(H,36,39)/t18-,21-,28-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291218
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C27H30N8O2/c1-2-35-13-18(11-31-35)17-9-23-21(30-10-17)5-6-22(32-23)27(37)33-24-12-29-8-7-25(24)34-14-19(16-3-4-16)26(36)20(28)15-34/h5-13,16,19-20,26,36H,2-4,14-15,28H2,1H3,(H,33,37)/t19-,20-,26-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291224
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCn1cc(cn1)-c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C26H29N7O2/c1-3-33-14-19(11-29-33)18-5-4-17-6-7-21(30-22(17)10-18)26(35)31-23-12-28-9-8-24(23)32-13-16(2)25(34)20(27)15-32/h4-12,14,16,20,25,34H,3,13,15,27H2,1-2H3,(H,31,35)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291228
PNG
(N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H27N7O/c1-16-9-20(26)15-32(13-16)24-7-8-27-12-23(24)30-25(33)21-6-5-17-3-4-18(10-22(17)29-21)19-11-28-31(2)14-19/h3-8,10-12,14,16,20H,9,13,15,26H2,1-2H3,(H,30,33)/t16-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM291221
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C28H32N8O2/c29-12-17-6-9-35(10-7-17)19-11-24-22(32-13-19)3-4-23(33-24)28(38)34-25-14-31-8-5-26(25)36-15-20(18-1-2-18)27(37)21(30)16-36/h3-5,8,11,13-14,17-18,20-21,27,37H,1-2,6-7,9-10,15-16,30H2,(H,34,38)/t20-,21-,27-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM291221
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C28H32N8O2/c29-12-17-6-9-35(10-7-17)19-11-24-22(32-13-19)3-4-23(33-24)28(38)34-25-14-31-8-5-26(25)36-15-20(18-1-2-18)27(37)21(30)16-36/h3-5,8,11,13-14,17-18,20-21,27,37H,1-2,6-7,9-10,15-16,30H2,(H,34,38)/t20-,21-,27-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291225
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H28N6O3/c1-16-14-33(15-20(28)26(16)34)24-9-10-29-13-23(24)32-27(35)21-7-5-17-3-4-18(11-22(17)31-21)19-6-8-25(36-2)30-12-19/h3-13,16,20,26,34H,14-15,28H2,1-2H3,(H,32,35)/t16-,20+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291227
PNG
(N-(4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cccnc1
Show InChI InChI=1S/C26H26N6O2/c1-16-14-32(15-20(27)25(16)33)24-8-10-29-13-23(24)31-26(34)21-7-6-17-4-5-18(11-22(17)30-21)19-3-2-9-28-12-19/h2-13,16,20,25,33H,14-15,27H2,1H3,(H,31,34)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291202
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCN1CCN(CC1=O)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H33N7O3/c1-3-32-10-11-33(16-25(32)35)19-6-4-18-5-7-21(30-22(18)12-19)27(37)31-23-13-29-9-8-24(23)34-14-17(2)26(36)20(28)15-34/h4-9,12-13,17,20,26,36H,3,10-11,14-16,28H2,1-2H3,(H,31,37)/t17-,20+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291203
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CCN1CCN(CC1=O)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N7O2/c1-3-32-10-11-33(17-26(32)35)21-6-4-19-5-7-22(30-23(19)13-21)27(36)31-24-14-29-9-8-25(24)34-15-18(2)12-20(28)16-34/h4-9,13-14,18,20H,3,10-12,15-17,28H2,1-2H3,(H,31,36)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291228
PNG
(N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H27N7O/c1-16-9-20(26)15-32(13-16)24-7-8-27-12-23(24)30-25(33)21-6-5-17-3-4-18(10-22(17)29-21)19-11-28-31(2)14-19/h3-8,10-12,14,16,20H,9,13,15,26H2,1-2H3,(H,30,33)/t16-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291194
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C30H38N6O3/c1-20-18-36(19-23(31)28(20)37)27-6-11-32-17-26(27)34-29(38)24-5-3-21-2-4-22(16-25(21)33-24)35-12-7-30(8-13-35)9-14-39-15-10-30/h2-6,11,16-17,20,23,28,37H,7-10,12-15,18-19,31H2,1H3,(H,34,38)/t20-,23+,28+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291200
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)c1ccncc1
Show InChI InChI=1S/C31H35N7O2/c1-20-18-38(19-25(32)30(20)39)29-8-13-34-17-28(29)36-31(40)26-5-3-23-2-4-24(16-27(23)35-26)37-14-9-22(10-15-37)21-6-11-33-12-7-21/h2-8,11-13,16-17,20,22,25,30,39H,9-10,14-15,18-19,32H2,1H3,(H,36,40)/t20-,25+,30+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291226
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C30H33N7O3/c1-19-17-37(18-23(31)29(19)38)27-8-9-32-16-26(27)35-30(39)24-6-4-20-2-3-21(14-25(20)34-24)22-5-7-28(33-15-22)36-10-12-40-13-11-36/h2-9,14-16,19,23,29,38H,10-13,17-18,31H2,1H3,(H,35,39)/t19-,23+,29+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291223
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H27N7O2/c1-15-12-32(14-19(26)24(15)33)23-7-8-27-11-22(23)30-25(34)20-6-5-16-3-4-17(9-21(16)29-20)18-10-28-31(2)13-18/h3-11,13,15,19,24,33H,12,14,26H2,1-2H3,(H,30,34)/t15-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291193
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H30N6O2/c1-17-12-19(26)16-31(15-17)24-6-7-27-14-23(24)29-25(32)21-5-3-18-2-4-20(13-22(18)28-21)30-8-10-33-11-9-30/h2-7,13-14,17,19H,8-12,15-16,26H2,1H3,(H,29,32)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291185
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C26H27N7O3/c1-15-13-33(14-18(27)25(15)34)23-7-8-28-12-22(23)32-26(35)20-5-4-19-21(31-20)9-17(11-29-19)16-3-6-24(36-2)30-10-16/h3-12,15,18,25,34H,13-14,27H2,1-2H3,(H,32,35)/t15-,18+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291182
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES COc1cc(F)c(c(F)c1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H26F2N6O2/c1-15-7-17(30)14-35(13-15)25-5-6-31-12-24(25)34-27(36)22-4-3-21-23(33-22)8-16(11-32-21)26-19(28)9-18(37-2)10-20(26)29/h3-6,8-12,15,17H,7,13-14,30H2,1-2H3,(H,34,36)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291232
PNG
(US9580418, Example 52)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccc(OC2CCOCC2)nc1
Show InChI InChI=1S/C31H34N6O4/c1-19-17-37(18-24(32)30(19)38)28-8-11-33-16-27(28)36-31(39)25-6-4-20-2-3-21(14-26(20)35-25)22-5-7-29(34-15-22)41-23-9-12-40-13-10-23/h2-8,11,14-16,19,23-24,30,38H,9-10,12-13,17-18,32H2,1H3,(H,36,39)/t19-,24+,30+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291173
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H24F2N6O/c1-15-9-17(29)14-34(13-15)24-7-8-30-12-23(24)33-26(35)21-6-5-20-22(32-21)10-16(11-31-20)25-18(27)3-2-4-19(25)28/h2-8,10-12,15,17H,9,13-14,29H2,1H3,(H,33,35)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291229
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)-c1ccccc1C#N
Show InChI InChI=1S/C28H26N6O/c1-18-12-22(30)17-34(16-18)27-10-11-31-15-26(27)33-28(35)24-9-8-19-6-7-20(13-25(19)32-24)23-5-3-2-4-21(23)14-29/h2-11,13,15,18,22H,12,16-17,30H2,1H3,(H,33,35)/t18-,22+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291205
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES COC1CCN(CC1)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H34N6O2/c1-18-13-20(28)17-33(16-18)26-7-10-29-15-25(26)31-27(34)23-6-4-19-3-5-21(14-24(19)30-23)32-11-8-22(35-2)9-12-32/h3-7,10,14-15,18,20,22H,8-9,11-13,16-17,28H2,1-2H3,(H,31,34)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291204
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES COC1CCN(CC1)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C27H34N6O3/c1-17-15-33(16-21(28)26(17)34)25-7-10-29-14-24(25)31-27(35)22-6-4-18-3-5-19(13-23(18)30-22)32-11-8-20(36-2)9-12-32/h3-7,10,13-14,17,20-21,26,34H,8-9,11-12,15-16,28H2,1-2H3,(H,31,35)/t17-,21+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291196
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C27H31N7O2/c1-17-15-34(16-21(29)26(17)35)25-6-9-30-14-24(25)32-27(36)22-5-3-19-2-4-20(12-23(19)31-22)33-10-7-18(13-28)8-11-33/h2-6,9,12,14,17-18,21,26,35H,7-8,10-11,15-16,29H2,1H3,(H,32,36)/t17-,21+,26+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291189
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C24H29N5O2/c1-14(2)17-5-4-16-6-7-19(27-20(16)10-17)24(31)28-21-11-26-9-8-22(21)29-12-15(3)23(30)18(25)13-29/h4-11,14-15,18,23,30H,12-13,25H2,1-3H3,(H,28,31)/t15-,18+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291216
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES COc1ccc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C28H29N7O3/c1-38-26-7-4-17(11-32-26)18-10-23-21(31-12-18)5-6-22(33-23)28(37)34-24-13-30-9-8-25(24)35-14-19(16-2-3-16)27(36)20(29)15-35/h4-13,16,19-20,27,36H,2-3,14-15,29H2,1H3,(H,34,37)/t19-,20-,27-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291214
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC1
Show InChI InChI=1S/C24H28N6O/c1-16-11-18(25)15-30(14-16)23-7-8-26-13-22(23)28-24(31)20-6-4-17-3-5-19(12-21(17)27-20)29-9-2-10-29/h3-8,12-13,16,18H,2,9-11,14-15,25H2,1H3,(H,28,31)/t16-,18+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291206
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H39N7O3/c1-20-18-37(19-24(31)29(20)38)28-6-9-32-17-27(28)34-30(39)25-5-3-21-2-4-23(16-26(21)33-25)35-10-7-22(8-11-35)36-12-14-40-15-13-36/h2-6,9,16-17,20,22,24,29,38H,7-8,10-15,18-19,31H2,1H3,(H,34,39)/t20-,24+,29+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291191
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C25H30N6O3/c1-16-14-31(15-19(26)24(16)32)23-6-7-27-13-22(23)29-25(33)20-5-3-17-2-4-18(12-21(17)28-20)30-8-10-34-11-9-30/h2-7,12-13,16,19,24,32H,8-11,14-15,26H2,1H3,(H,29,33)/t16-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291184
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CC(C)c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C23H28N6O2/c1-13(2)15-8-19-17(26-9-15)4-5-18(27-19)23(31)28-20-10-25-7-6-21(20)29-11-14(3)22(30)16(24)12-29/h4-10,13-14,16,22,30H,11-12,24H2,1-3H3,(H,28,31)/t14-,16+,22+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291175
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CC(C)c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C23H28N6O/c1-14(2)16-9-20-18(26-10-16)4-5-19(27-20)23(30)28-21-11-25-7-6-22(21)29-12-15(3)8-17(24)13-29/h4-7,9-11,14-15,17H,8,12-13,24H2,1-3H3,(H,28,30)/t15-,17+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291215
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES COc1cc(F)c(c(F)c1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C29H28F2N6O3/c1-40-17-9-19(30)27(20(31)10-17)16-8-24-22(34-11-16)4-5-23(35-24)29(39)36-25-12-33-7-6-26(25)37-13-18(15-2-3-15)28(38)21(32)14-37/h4-12,15,18,21,28,38H,2-3,13-14,32H2,1H3,(H,36,39)/t18-,21-,28-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291219
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C26H28N8O2/c1-33-12-17(10-30-33)16-8-22-20(29-9-16)4-5-21(31-22)26(36)32-23-11-28-7-6-24(23)34-13-18(15-2-3-15)25(35)19(27)14-34/h4-12,15,18-19,25,35H,2-3,13-14,27H2,1H3,(H,32,36)/t18-,19-,25-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291224
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCn1cc(cn1)-c1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C26H29N7O2/c1-3-33-14-19(11-29-33)18-5-4-17-6-7-21(30-22(17)10-18)26(35)31-23-12-28-9-8-24(23)32-13-16(2)25(34)20(27)15-32/h4-12,14,16,20,25,34H,3,13,15,27H2,1-2H3,(H,31,35)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291210
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCCC1
Show InChI InChI=1S/C25H30N6O2/c1-16-14-31(15-19(26)24(16)32)23-8-9-27-13-22(23)29-25(33)20-7-5-17-4-6-18(12-21(17)28-20)30-10-2-3-11-30/h4-9,12-13,16,19,24,32H,2-3,10-11,14-15,26H2,1H3,(H,29,33)/t16-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291231
PNG
(N-{4-[(3S,5R)-3-Amino-5-(trifluoromethyl)piperidin...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1ccccc1C#N)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)18-10-19(32)15-37(14-18)25-7-8-33-13-24(25)36-26(38)22-6-5-21-23(35-22)9-17(12-34-21)20-4-2-1-3-16(20)11-31/h1-9,12-13,18-19H,10,14-15,32H2,(H,36,38)/t18-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291217
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C31H34N8O3/c32-23-18-39(17-22(30(23)40)19-1-2-19)28-7-8-33-16-27(28)37-31(41)25-5-4-24-26(36-25)13-21(15-34-24)20-3-6-29(35-14-20)38-9-11-42-12-10-38/h3-8,13-16,19,22-23,30,40H,1-2,9-12,17-18,32H2,(H,37,41)/t22-,23-,30-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291218
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@@H](N)[C@H](O)[C@H](C1)C1CC1
Show InChI InChI=1S/C27H30N8O2/c1-2-35-13-18(11-31-35)17-9-23-21(30-10-17)5-6-22(32-23)27(37)33-24-12-29-8-7-25(24)34-14-19(16-3-4-16)26(36)20(28)15-34/h5-13,16,19-20,26,36H,2-4,14-15,28H2,1H3,(H,33,37)/t19-,20-,26-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291230
PNG
(N-(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(O)CC1
Show InChI InChI=1S/C26H32N6O2/c1-17-12-19(27)16-32(15-17)25-6-9-28-14-24(25)30-26(34)22-5-3-18-2-4-20(13-23(18)29-22)31-10-7-21(33)8-11-31/h2-6,9,13-14,17,19,21,33H,7-8,10-12,15-16,27H2,1H3,(H,30,34)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291190
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)C1CCOCC1
Show InChI InChI=1S/C26H31N5O3/c1-16-14-31(15-20(27)25(16)32)24-6-9-28-13-23(24)30-26(33)21-5-4-18-2-3-19(12-22(18)29-21)17-7-10-34-11-8-17/h2-6,9,12-13,16-17,20,25,32H,7-8,10-11,14-15,27H2,1H3,(H,30,33)/t16-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291212
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1S/C26H32N6O2/c1-16-12-31(13-19(27)24(16)33)23-8-9-28-11-22(23)30-25(34)20-7-5-17-4-6-18(10-21(17)29-20)32-14-26(2,3)15-32/h4-11,16,19,24,33H,12-15,27H2,1-3H3,(H,30,34)/t16-,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291208
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(C1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O2/c1-15-12-35(14-19(30)24(15)36)23-6-8-31-11-22(23)33-25(37)20-5-3-16-2-4-18(10-21(16)32-20)34-9-7-17(13-34)26(27,28)29/h2-6,8,10-11,15,17,19,24,36H,7,9,12-14,30H2,1H3,(H,33,37)/t15-,17?,19+,24+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291201
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)c1ccncc1
Show InChI InChI=1S/C31H35N7O/c1-21-16-25(32)20-38(19-21)30-8-13-34-18-29(30)36-31(39)27-5-3-24-2-4-26(17-28(24)35-27)37-14-9-23(10-15-37)22-6-11-33-12-7-22/h2-8,11-13,17-18,21,23,25H,9-10,14-16,19-20,32H2,1H3,(H,36,39)/t21-,25+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291183
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C25H28N8O/c1-3-33-14-18(11-29-33)17-9-22-20(28-10-17)4-5-21(30-22)25(34)31-23-12-27-7-6-24(23)32-13-16(2)8-19(26)15-32/h4-7,9-12,14,16,19H,3,8,13,15,26H2,1-2H3,(H,31,34)/t16-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291176
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)C1CCOCC1
Show InChI InChI=1S/C25H30N6O2/c1-16-10-19(26)15-31(14-16)24-4-7-27-13-23(24)30-25(32)21-3-2-20-22(29-21)11-18(12-28-20)17-5-8-33-9-6-17/h2-4,7,11-13,16-17,19H,5-6,8-10,14-15,26H2,1H3,(H,30,32)/t16-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291199
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1
Show InChI InChI=1S/C26H33N7O/c1-18-13-20(27)17-33(16-18)25-7-8-28-15-24(25)30-26(34)22-6-4-19-3-5-21(14-23(19)29-22)32-11-9-31(2)10-12-32/h3-8,14-15,18,20H,9-13,16-17,27H2,1-2H3,(H,30,34)/t18-,20+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291209
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(C1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O/c1-16-10-19(30)15-35(13-16)24-6-8-31-12-23(24)33-25(36)21-5-3-17-2-4-20(11-22(17)32-21)34-9-7-18(14-34)26(27,28)29/h2-6,8,11-12,16,18-19H,7,9-10,13-15,30H2,1H3,(H,33,36)/t16-,18?,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291186
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C24H29N7O3/c1-15-13-31(14-17(25)23(15)32)22-4-5-26-12-21(22)29-24(33)19-3-2-18-20(28-19)10-16(11-27-18)30-6-8-34-9-7-30/h2-5,10-12,15,17,23,32H,6-9,13-14,25H2,1H3,(H,29,33)/t15-,17+,23+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291198
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCN(C)CC1
Show InChI InChI=1S/C26H33N7O2/c1-17-15-33(16-20(27)25(17)34)24-7-8-28-14-23(24)30-26(35)21-6-4-18-3-5-19(13-22(18)29-21)32-11-9-31(2)10-12-32/h3-8,13-14,17,20,25,34H,9-12,15-16,27H2,1-2H3,(H,30,35)/t17-,20+,25+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291197
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C27H31N7O/c1-18-12-21(29)17-34(16-18)26-6-9-30-15-25(26)32-27(35)23-5-3-20-2-4-22(13-24(20)31-23)33-10-7-19(14-28)8-11-33/h2-6,9,13,15,18-19,21H,7-8,10-12,16-17,29H2,1H3,(H,32,35)/t18-,21+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291211
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCCC1
Show InChI InChI=1S/C25H30N6O/c1-17-12-19(26)16-31(15-17)24-8-9-27-14-23(24)29-25(32)21-7-5-18-4-6-20(13-22(18)28-21)30-10-2-3-11-30/h4-9,13-14,17,19H,2-3,10-12,15-16,26H2,1H3,(H,29,32)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291195
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C30H38N6O2/c1-21-16-23(31)20-36(19-21)28-6-11-32-18-27(28)34-29(37)25-5-3-22-2-4-24(17-26(22)33-25)35-12-7-30(8-13-35)9-14-38-15-10-30/h2-6,11,17-18,21,23H,7-10,12-16,19-20,31H2,1H3,(H,34,37)/t21-,23+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291187
PNG
(N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperid...)
Show SMILES CCc1ccc2ccc(nc2c1)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H](O)[C@H](N)C1
Show InChI InChI=1S/C23H27N5O2/c1-3-15-4-5-16-6-7-18(26-19(16)10-15)23(30)27-20-11-25-9-8-21(20)28-12-14(2)22(29)17(24)13-28/h4-11,14,17,22,29H,3,12-13,24H2,1-2H3,(H,27,30)/t14-,17+,22+/m0/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291207
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H39N7O2/c1-21-16-23(31)20-37(19-21)29-6-9-32-18-28(29)34-30(38)26-5-3-22-2-4-25(17-27(22)33-26)35-10-7-24(8-11-35)36-12-14-39-15-13-36/h2-6,9,17-18,21,23-24H,7-8,10-16,19-20,31H2,1H3,(H,34,38)/t21-,23+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291220
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C31H39N7O3/c32-23-19-38(18-22(29(23)39)20-1-2-20)28-5-10-33-17-27(28)36-30(40)25-4-3-24-26(35-25)15-21(16-34-24)37-11-6-31(7-12-37)8-13-41-14-9-31/h3-5,10,15-17,20,22-23,29,39H,1-2,6-9,11-14,18-19,32H2,(H,36,40)/t22-,23-,29-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291222
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC2(CCCO2)CC1
Show InChI InChI=1S/C30H37N7O3/c31-22-18-37(17-21(28(22)38)19-2-3-19)27-6-10-32-16-26(27)35-29(39)24-5-4-23-25(34-24)14-20(15-33-23)36-11-8-30(9-12-36)7-1-13-40-30/h4-6,10,14-16,19,21-22,28,38H,1-3,7-9,11-13,17-18,31H2,(H,35,39)/t21-,22-,28-/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291221
PNG
(N-{4-[(3R,4R,5S)-3-Amino-5-cyclopropyl-4-hydroxypi...)
Show SMILES N[C@@H]1CN(C[C@H](C2CC2)[C@H]1O)c1ccncc1NC(=O)c1ccc2ncc(cc2n1)N1CCC(CC1)C#N
Show InChI InChI=1S/C28H32N8O2/c29-12-17-6-9-35(10-7-17)19-11-24-22(32-13-19)3-4-23(33-24)28(38)34-25-14-31-8-5-26(25)36-15-20(18-1-2-18)27(37)21(30)16-36/h3-5,8,11,13-14,17-18,20-21,27,37H,1-2,6-7,9-10,15-16,30H2,(H,34,38)/t20-,21-,27-/m1/s1
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM291213
PNG
(N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyrid...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CC(C)(C)C1
Show InChI InChI=1S/C26H32N6O/c1-17-10-19(27)14-31(13-17)24-8-9-28-12-23(24)30-25(33)21-7-5-18-4-6-20(11-22(18)29-21)32-15-26(2,3)16-32/h4-9,11-12,17,19H,10,13-16,27H2,1-3H3,(H,30,33)/t17-,19+/m1/s1
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Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9580418 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%