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Patent code US9580442

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291359
PNG
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291358
PNG
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291363
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Show SMILES C(N1CCOCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H26N6O3/c1-2-19(18-4-5-27-21(18)3-1)24-29-22-20-14-17(16-31-6-10-33-11-7-31)15-28-26(20)35-23(22)25(30-24)32-8-12-34-13-9-32/h1-5,14-15,27H,6-13,16H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291355
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291360
PNG
(US9580442, Example H | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291357
PNG
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291361
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291365
PNG
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291354
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291355
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291364
PNG
(US9580442, Example L | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291366
PNG
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291365
PNG
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291362
PNG
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM291356
PNG
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22)
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291354
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291356
PNG
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22)
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291360
PNG
(US9580442, Example H | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291363
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Show SMILES C(N1CCOCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H26N6O3/c1-2-19(18-4-5-27-21(18)3-1)24-29-22-20-14-17(16-31-6-10-33-11-7-31)15-28-26(20)35-23(22)25(30-24)32-8-12-34-13-9-32/h1-5,14-15,27H,6-13,16H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291357
PNG
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291359
PNG
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291357
PNG
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291365
PNG
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291356
PNG
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22)
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291356
PNG
(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C20H16N6O2/c1-2-14-15-16(28-20(14)23-5-1)19(26-8-10-27-11-9-26)25-18(24-15)13-4-7-22-17-12(13)3-6-21-17/h1-7H,8-11H2,(H,21,22)
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291358
PNG
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291364
PNG
(US9580442, Example L | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291358
PNG
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291366
PNG
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291354
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291355
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291360
PNG
(US9580442, Example H | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291365
PNG
(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Show SMILES C1CN(CCO1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C25H24N6O3/c1-2-18(17-4-5-26-20(17)3-1)23-28-21-19-14-16(30-6-10-32-11-7-30)15-27-25(19)34-22(21)24(29-23)31-8-12-33-13-9-31/h1-5,14-15,26H,6-13H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291359
PNG
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291358
PNG
((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Show SMILES CN1CCN(CC1)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C29H29N7O3/c1-34-9-11-35(12-10-34)24(37)6-5-19-17-22-25-26(39-29(22)31-18-19)28(36-13-15-38-16-14-36)33-27(32-25)21-3-2-4-23-20(21)7-8-30-23/h2-8,17-18,30H,9-16H2,1H3/b6-5+
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291362
PNG
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291355
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3oc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5O2/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291363
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Show SMILES C(N1CCOCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H26N6O3/c1-2-19(18-4-5-27-21(18)3-1)24-29-22-20-14-17(16-31-6-10-33-11-7-31)15-28-26(20)35-23(22)25(30-24)32-8-12-34-13-9-32/h1-5,14-15,27H,6-13,16H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291360
PNG
(US9580442, Example H | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES CN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C24H24N6O2/c1-29(2)14-15-12-18-20-21(32-24(18)26-13-15)23(30-8-10-31-11-9-30)28-22(27-20)17-4-3-5-19-16(17)6-7-25-19/h3-7,12-13,25H,8-11,14H2,1-2H3
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM291361
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2
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Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291361
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2
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n/an/a 508n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291366
PNG
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2
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n/an/a 597n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291364
PNG
(US9580442, Example L | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3
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n/an/a 604n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291357
PNG
(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cc(cnc3oc12)-c1cccc2[nH]ccc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C29H22N6O2/c1-3-18(19-7-9-30-23(19)5-1)17-15-22-25-26(37-29(22)32-16-17)28(35-11-13-36-14-12-35)34-27(33-25)21-4-2-6-24-20(21)8-10-31-24/h1-10,15-16,30-31H,11-14H2
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n/an/a 627n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM291362
PNG
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3
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n/an/a 680n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291354
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Show SMILES C1CN(CCO1)c1nc(nc2c3cccnc3sc12)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C21H17N5OS/c1-3-14(13-6-8-22-16(13)5-1)19-24-17-15-4-2-7-23-21(15)28-18(17)20(25-19)26-9-11-27-12-10-26/h1-8,22H,9-12H2
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n/an/a 873n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291362
PNG
(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Show SMILES CN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C27H29N7O2/c1-32-7-9-33(10-8-32)17-18-15-21-23-24(36-27(21)29-16-18)26(34-11-13-35-14-12-34)31-25(30-23)20-3-2-4-22-19(20)5-6-28-22/h2-6,15-16,28H,7-14,17H2,1H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291359
PNG
((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Show SMILES CN(C)C(=O)\C=C\c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H24N6O3/c1-31(2)21(33)7-6-16-14-19-22-23(35-26(19)28-15-16)25(32-10-12-34-13-11-32)30-24(29-22)18-4-3-5-20-17(18)8-9-27-20/h3-9,14-15,27H,10-13H2,1-2H3/b7-6+
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n/an/a 1.66E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291364
PNG
(US9580442, Example L | [2-(1H-Indol-4-yl)-4-morpho...)
Show SMILES COCCN(C)Cc1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H28N6O3/c1-31(8-11-33-2)16-17-14-20-22-23(35-26(20)28-15-17)25(32-9-12-34-13-10-32)30-24(29-22)19-4-3-5-21-18(19)6-7-27-21/h3-7,14-15,27H,8-13,16H2,1-2H3
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n/an/a 1.82E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291366
PNG
(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Show SMILES N#CCCN1CCN(Cc2cnc3oc4c(nc(nc4c3c2)-c2cccc3[nH]ccc23)N2CCOCC2)CC1
Show InChI InChI=1S/C29H30N8O2/c30-6-2-8-35-9-11-36(12-10-35)19-20-17-23-25-26(39-29(23)32-18-20)28(37-13-15-38-16-14-37)34-27(33-25)22-3-1-4-24-21(22)5-7-31-24/h1,3-5,7,17-18,31H,2,8-16,19H2
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n/an/a 2.54E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291363
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Show SMILES C(N1CCOCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C26H26N6O3/c1-2-19(18-4-5-27-21(18)3-1)24-29-22-20-14-17(16-31-6-10-33-11-7-31)15-28-26(20)35-23(22)25(30-24)32-8-12-34-13-9-32/h1-5,14-15,27H,6-13,16H2
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n/an/a 2.61E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM291361
PNG
(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1
Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2
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n/an/a 4.95E+3n/an/an/an/an/an/a



Karus Therapeutics Limited

US Patent


Assay Description
PI3K Isoform using biochemical assay.


US Patent US9580442 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%