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Patent code US9586900

Compile Data Set for Download or QSAR
Found 121 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294200
PNG
(US9586900, Example 104)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H27NO5S/c1-19-18-22(10-13-24(19)31-16-17-33(2,29)30)27-15-14-25(26(27)28)32-23-11-8-21(9-12-23)20-6-4-3-5-7-20/h3-13,18,25H,14-17H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294163
PNG
(US9586900, Example 66)
Show SMILES COc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H27NO6S/c1-31-25-18-21(10-13-23(25)32-16-17-34(2,29)30)27-15-14-24(26(27)28)33-22-11-8-20(9-12-22)19-6-4-3-5-7-19/h3-13,18,24H,14-17H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294217
PNG
(US9586900, Example 121)
Show SMILES COc1cc(ccc1OC[C@H](O)C1CC1)N1CC=C(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C25H27NO5/c1-29-24-14-19(8-11-22(24)30-15-21(27)18-4-5-18)26-13-12-23(25(26)28)31-20-9-6-17(7-10-20)16-2-3-16/h6-12,14,16,18,21,27H,2-5,13,15H2,1H3/t21-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294201
PNG
(US9586900, Example 105)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CC[C@@H](Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H27NO5S/c1-19-18-22(10-13-24(19)31-16-17-33(2,29)30)27-15-14-25(26(27)28)32-23-11-8-21(9-12-23)20-6-4-3-5-7-20/h3-13,18,25H,14-17H2,1-2H3/t25-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294154
PNG
(US9586900, Example 57)
Show SMILES COc1cc(ccc1OCC1(O)CCS(=O)(=O)CC1)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C29H31NO7S/c1-35-27-19-23(9-12-25(27)36-20-29(32)14-17-38(33,34)18-15-29)30-16-13-26(28(30)31)37-24-10-7-22(8-11-24)21-5-3-2-4-6-21/h2-12,19,26,32H,13-18,20H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294118
PNG
(US9586900, Example 21)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC[C@@H](Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H29NO5/c1-27(2,30)18-32-23-14-11-21(17-25(23)31-3)28-16-15-24(26(28)29)33-22-12-9-20(10-13-22)19-7-5-4-6-8-19/h4-14,17,24,30H,15-16,18H2,1-3H3/t24-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294206
PNG
(US9586900, Example 110)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CC[C@@H](Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H26FNO5S/c1-18-17-22(9-12-24(18)32-15-16-34(2,30)31)28-14-13-25(26(28)29)33-23-10-5-20(6-11-23)19-3-7-21(27)8-4-19/h3-12,17,25H,13-16H2,1-2H3/t25-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294218
PNG
(US9586900, Example 122)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC=C(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H27NO5/c1-27(2,30)18-32-23-14-11-21(17-25(23)31-3)28-16-15-24(26(28)29)33-22-12-9-20(10-13-22)19-7-5-4-6-8-19/h4-15,17,30H,16,18H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294212
PNG
(US9586900, Example 116)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC=C(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H27NO5/c1-24(2,27)15-29-20-11-8-18(14-22(20)28-3)25-13-12-21(23(25)26)30-19-9-6-17(7-10-19)16-4-5-16/h6-12,14,16,27H,4-5,13,15H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294167
PNG
(US9586900, Example 71)
Show SMILES COc1cc(ccc1OCCS(C)(=O)=O)N1CC[C@@H](Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C23H27NO6S/c1-28-22-15-18(7-10-20(22)29-13-14-31(2,26)27)24-12-11-21(23(24)25)30-19-8-5-17(6-9-19)16-3-4-16/h5-10,15-16,21H,3-4,11-14H2,1-2H3/t21-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294116
PNG
(US9586900, Example 19)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H29NO5/c1-27(2,30)18-32-23-14-11-21(17-25(23)31-3)28-16-15-24(26(28)29)33-22-12-9-20(10-13-22)19-7-5-4-6-8-19/h4-14,17,24,30H,15-16,18H2,1-3H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294176
PNG
(US9586900, Example 80)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H29NO4/c1-19-17-22(11-14-24(19)31-18-27(2,3)30)28-16-15-25(26(28)29)32-23-12-9-21(10-13-23)20-7-5-4-6-8-20/h4-14,17,25,30H,15-16,18H2,1-3H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294215
PNG
(US9586900, Example 119)
Show SMILES COc1cc(ccc1OCC(C)(O)CO)N1CC=C(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H27NO6/c1-24(28,14-26)15-30-20-10-7-18(13-22(20)29-2)25-12-11-21(23(25)27)31-19-8-5-17(6-9-19)16-3-4-16/h5-11,13,16,26,28H,3-4,12,14-15H2,1-2H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294141
PNG
(US9586900, Example 44)
Show SMILES COc1cc(ccc1OC[C@H](O)C1CC1)N1CC[C@@H](Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H29NO5/c1-32-27-17-22(11-14-25(27)33-18-24(30)21-7-8-21)29-16-15-26(28(29)31)34-23-12-9-20(10-13-23)19-5-3-2-4-6-19/h2-6,9-14,17,21,24,26,30H,7-8,15-16,18H2,1H3/t24-,26+/m0/s1
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294145
PNG
(US9586900, Example 48)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H31NO7S/c1-3-37(32,33)19-23(30)18-35-25-14-11-22(17-27(25)34-2)29-16-15-26(28(29)31)36-24-12-9-21(10-13-24)20-7-5-4-6-8-20/h4-14,17,23,26,30H,3,15-16,18-19H2,1-2H3/t23-,26?/m0/s1
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294135
PNG
(US9586900, Example 38)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-n2cccc2)C1=O
Show InChI InChI=1S/C25H28N2O5/c1-25(2,29)17-31-21-11-8-19(16-23(21)30-3)27-15-12-22(24(27)28)32-20-9-6-18(7-10-20)26-13-4-5-14-26/h4-11,13-14,16,22,29H,12,15,17H2,1-3H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294180
PNG
(US9586900, Example 84)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CC[C@@H](Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO4/c1-16-14-19(8-11-21(16)28-15-24(2,3)27)25-13-12-22(23(25)26)29-20-9-6-18(7-10-20)17-4-5-17/h6-11,14,17,22,27H,4-5,12-13,15H2,1-3H3/t22-/m1/s1
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294203
PNG
((S)-3-(Biphenyl-4-yloxy)-1-(3-methyl-4-(2-(methyls...)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C26H26FNO5S/c1-18-17-20(9-12-24(18)32-15-16-34(2,30)31)28-14-13-25(26(28)29)33-21-10-7-19(8-11-21)22-5-3-4-6-23(22)27/h3-12,17,25H,13-16H2,1-2H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294204
PNG
(US9586900, Example 108)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2cccc(F)c2)C1=O
Show InChI InChI=1S/C26H26FNO5S/c1-18-16-22(8-11-24(18)32-14-15-34(2,30)31)28-13-12-25(26(28)29)33-23-9-6-19(7-10-23)20-4-3-5-21(27)17-20/h3-11,16-17,25H,12-15H2,1-2H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294165
PNG
(US9586900, Example 68)
Show SMILES COc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2cccc(F)c2)C1=O
Show InChI InChI=1S/C26H26FNO6S/c1-32-25-17-21(8-11-23(25)33-14-15-35(2,30)31)28-13-12-24(26(28)29)34-22-9-6-18(7-10-22)19-4-3-5-20(27)16-19/h3-11,16-17,24H,12-15H2,1-2H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294198
PNG
(US9586900, Example 102)
Show SMILES C[S+]([O-])CCOc1ccc(cc1C)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H27NO4S/c1-19-18-22(10-13-24(19)30-16-17-32(2)29)27-15-14-25(26(27)28)31-23-11-8-21(9-12-23)20-6-4-3-5-7-20/h3-13,18,25H,14-17H2,1-2H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294205
PNG
(US9586900, Example 109)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H26FNO5S/c1-18-17-22(9-12-24(18)32-15-16-34(2,30)31)28-14-13-25(26(28)29)33-23-10-5-20(6-11-23)19-3-7-21(27)8-4-19/h3-12,17,25H,13-16H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294164
PNG
(US9586900, Example 67)
Show SMILES COc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C26H26FNO6S/c1-32-25-17-19(9-12-23(25)33-15-16-35(2,30)31)28-14-13-24(26(28)29)34-20-10-7-18(8-11-20)21-5-3-4-6-22(21)27/h3-12,17,24H,13-16H2,1-2H3
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6n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294146
PNG
(US9586900, Example 49)
Show SMILES CCS(=O)(=O)C[C@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H31NO7S/c1-3-37(32,33)19-23(30)18-35-25-14-11-22(17-27(25)34-2)29-16-15-26(28(29)31)36-24-12-9-21(10-13-24)20-7-5-4-6-8-20/h4-14,17,23,26,30H,3,15-16,18-19H2,1-2H3/t23-,26?/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294144
PNG
(US9586900, Example 47)
Show SMILES COc1cc(ccc1OCC1(O)CC(F)(F)C1)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H27F2NO5/c1-34-25-15-21(9-12-23(25)35-18-27(33)16-28(29,30)17-27)31-14-13-24(26(31)32)36-22-10-7-20(8-11-22)19-5-3-2-4-6-19/h2-12,15,24,33H,13-14,16-18H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294210
PNG
(US9586900, Example 114)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C23H27NO5S/c1-16-15-19(7-10-21(16)28-13-14-30(2,26)27)24-12-11-22(23(24)25)29-20-8-5-18(6-9-20)17-3-4-17/h5-10,15,17,22H,3-4,11-14H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294187
PNG
(US9586900, Example 91)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1C)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H31NO6S/c1-3-36(32,33)19-24(30)18-34-26-14-11-23(17-20(26)2)29-16-15-27(28(29)31)35-25-12-9-22(10-13-25)21-7-5-4-6-8-21/h4-14,17,24,27,30H,3,15-16,18-19H2,1-2H3/t24-,27?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294168
PNG
(US9586900, Example 72)
Show SMILES CS(=O)(=O)CCOc1ccc(cc1OCCF)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H28FNO6S/c1-36(31,32)18-17-34-24-12-9-22(19-26(24)33-16-14-28)29-15-13-25(27(29)30)35-23-10-7-21(8-11-23)20-5-3-2-4-6-20/h2-12,19,25H,13-18H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294166
PNG
(US9586900, Example 70)
Show SMILES COc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C23H27NO6S/c1-28-22-15-18(7-10-20(22)29-13-14-31(2,26)27)24-12-11-21(23(24)25)30-19-8-5-17(6-9-19)16-3-4-16/h5-10,15-16,21H,3-4,11-14H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294162
PNG
(US9586900, Example 65)
Show SMILES COc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C21H22F3NO7S/c1-29-19-13-14(3-8-17(19)30-11-12-33(2,27)28)25-10-9-18(20(25)26)31-15-4-6-16(7-5-15)32-21(22,23)24/h3-8,13,18H,9-12H2,1-2H3
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8n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294121
PNG
(US9586900, Example 24)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C27H28FNO5/c1-27(2,31)17-33-23-13-10-19(16-25(23)32-3)29-15-14-24(26(29)30)34-20-11-8-18(9-12-20)21-6-4-5-7-22(21)28/h4-13,16,24,31H,14-15,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294214
PNG
(US9586900, Example 118)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CC=C(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H27NO4/c1-16-14-19(8-11-21(16)28-15-24(2,3)27)25-13-12-22(23(25)26)29-20-9-6-18(7-10-20)17-4-5-17/h6-12,14,17,27H,4-5,13,15H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294155
PNG
(US9586900, Example 58)
Show SMILES COc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H29NO7S/c1-33-26-16-21(10-13-24(26)34-17-22(29)18-36(2,31)32)28-15-14-25(27(28)30)35-23-11-8-20(9-12-23)19-6-4-3-5-7-19/h3-13,16,22,25,29H,14-15,17-18H2,1-2H3/t22-,25?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294186
PNG
(US9586900, Example 90)
Show SMILES Cc1cc(ccc1OCC1(O)CC(F)(F)C1)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H27F2NO4/c1-19-15-22(9-12-24(19)34-18-27(33)16-28(29,30)17-27)31-14-13-25(26(31)32)35-23-10-7-21(8-11-23)20-5-3-2-4-6-20/h2-12,15,25,33H,13-14,16-18H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294216
PNG
(US9586900, Example 120)
Show SMILES COc1cc(ccc1O)N1CC=C(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C20H19NO4/c1-24-19-12-15(6-9-17(19)22)21-11-10-18(20(21)23)25-16-7-4-14(5-8-16)13-2-3-13/h4-10,12-13,22H,2-3,11H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294110
PNG
(US9586900, Example 15)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC[C@@H](Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H24F3NO6/c1-21(2,28)13-30-17-9-4-14(12-19(17)29-3)26-11-10-18(20(26)27)31-15-5-7-16(8-6-15)32-22(23,24)25/h4-9,12,18,28H,10-11,13H2,1-3H3/t18-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294211
PNG
(US9586900, Example 115)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC=C(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H22F3NO6/c1-21(2,28)13-30-17-9-4-14(12-19(17)29-3)26-11-10-18(20(26)27)31-15-5-7-16(8-6-15)32-22(23,24)25/h4-10,12,28H,11,13H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294159
PNG
(US9586900, Example 62)
Show SMILES COc1cc(ccc1OC[C@@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H29NO7S/c1-33-26-16-21(10-13-24(26)34-17-22(29)18-36(2,31)32)28-15-14-25(27(28)30)35-23-11-8-20(9-12-23)19-6-4-3-5-7-19/h3-13,16,22,25,29H,14-15,17-18H2,1-2H3/t22-,25?/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294175
PNG
(US9586900, Example 79)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CC[C@@H](Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-14-12-15(4-9-18(14)29-13-21(2,3)28)26-11-10-19(20(26)27)30-16-5-7-17(8-6-16)31-22(23,24)25/h4-9,12,19,28H,10-11,13H2,1-3H3/t19-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294178
PNG
(US9586900, Example 82)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO4/c1-16-14-19(8-11-21(16)28-15-24(2,3)27)25-13-12-22(23(25)26)29-20-9-6-18(7-10-20)17-4-5-17/h6-11,14,17,22,27H,4-5,12-13,15H2,1-3H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294127
PNG
(US9586900, Example 30)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(c(F)c2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H28FNO5/c1-27(2,31)17-33-23-12-9-19(15-25(23)32-3)29-14-13-24(26(29)30)34-20-10-11-21(22(28)16-20)18-7-5-4-6-8-18/h4-12,15-16,24,31H,13-14,17H2,1-3H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294143
PNG
(US9586900, Example 46)
Show SMILES COc1cc(ccc1OC[C@H](O)C1CC1)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C25H29NO5/c1-29-24-14-19(8-11-22(24)30-15-21(27)18-4-5-18)26-13-12-23(25(26)28)31-20-9-6-17(7-10-20)16-2-3-16/h6-11,14,16,18,21,23,27H,2-5,12-13,15H2,1H3/t21-,23?/m0/s1
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294171
PNG
(US9586900, Example 75)
Show SMILES COc1cc(ccc1OCCS(=O)(=O)CC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C29H33NO7S/c1-29(2,32)20-38(33,34)18-17-36-25-14-11-23(19-27(25)35-3)30-16-15-26(28(30)31)37-24-12-9-22(10-13-24)21-7-5-4-6-8-21/h4-14,19,26,32H,15-18,20H2,1-3H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294131
PNG
(US9586900, Example 34)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cn2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H28N2O5/c1-26(2,30)17-32-21-11-10-20(15-23(21)31-3)28-14-13-22(25(28)29)33-24-12-9-19(16-27-24)18-7-5-4-6-8-18/h4-12,15-16,22,30H,13-14,17H2,1-3H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294191
PNG
(US9586900, Example 95)
Show SMILES Cc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H29NO6S/c1-19-16-22(10-13-25(19)33-17-23(29)18-35(2,31)32)28-15-14-26(27(28)30)34-24-11-8-21(9-12-24)20-6-4-3-5-7-20/h3-13,16,23,26,29H,14-15,17-18H2,1-2H3/t23-,26?/m0/s1
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294173
PNG
(US9586900, Example 77)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-14-12-15(4-9-18(14)29-13-21(2,3)28)26-11-10-19(20(26)27)30-16-5-7-17(8-6-16)31-22(23,24)25/h4-9,12,19,28H,10-11,13H2,1-3H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294149
PNG
(US9586900, Example 52)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C25H31NO7S/c1-3-34(29,30)16-20(27)15-32-22-11-8-19(14-24(22)31-2)26-13-12-23(25(26)28)33-21-9-6-18(7-10-21)17-4-5-17/h6-11,14,17,20,23,27H,3-5,12-13,15-16H2,1-2H3/t20-,23?/m0/s1
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Bristol-Myers Squibb Company

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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294157
PNG
(US9586900, Example 60)
Show SMILES COc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO7S/c1-30-23-13-18(7-10-21(23)31-14-19(26)15-33(2,28)29)25-12-11-22(24(25)27)32-20-8-5-17(6-9-20)16-3-4-16/h5-10,13,16,19,22,26H,3-4,11-12,14-15H2,1-2H3/t19-,22?/m0/s1
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294156
PNG
(US9586900, Example 59)
Show SMILES COc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H28FNO7S/c1-34-26-15-21(9-12-24(26)35-16-22(30)17-37(2,32)33)29-14-13-25(27(29)31)36-23-10-5-19(6-11-23)18-3-7-20(28)8-4-18/h3-12,15,22,25,30H,13-14,16-17H2,1-2H3/t22-,25?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294140
PNG
(US9586900, Example 43)
Show SMILES COc1ccc(cc1OC)N1CCC(Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C24H23NO4/c1-27-21-13-10-19(16-23(21)28-2)25-15-14-22(24(25)26)29-20-11-8-18(9-12-20)17-6-4-3-5-7-17/h3-13,16,22H,14-15H2,1-2H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294195
PNG
(US9586900, Example 99)
Show SMILES Cc1cc(ccc1OC[C@@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H28FNO6S/c1-18-15-22(9-12-25(18)34-16-23(30)17-36(2,32)33)29-14-13-26(27(29)31)35-24-10-5-20(6-11-24)19-3-7-21(28)8-4-19/h3-12,15,23,26,30H,13-14,16-17H2,1-2H3/t23-,26?/m1/s1
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294151
PNG
(US9586900, Example 54)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H30FNO7S/c1-3-38(33,34)18-23(31)17-36-25-13-10-22(16-27(25)35-2)30-15-14-26(28(30)32)37-24-11-6-20(7-12-24)19-4-8-21(29)9-5-19/h4-13,16,23,26,31H,3,14-15,17-18H2,1-2H3/t23-,26?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294188
PNG
(US9586900, Example 92)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1C)N1CCC(Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H30FNO6S/c1-3-37(33,34)18-24(31)17-35-26-13-10-23(16-19(26)2)30-15-14-27(28(30)32)36-25-11-6-21(7-12-25)20-4-8-22(29)9-5-20/h4-13,16,24,27,31H,3,14-15,17-18H2,1-2H3/t24-,27?/m0/s1
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Bristol-Myers Squibb Company

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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294181
PNG
(US9586900, Example 85)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(I)cc2)C1=O
Show InChI InChI=1S/C21H24INO4/c1-14-12-16(6-9-18(14)26-13-21(2,3)25)23-11-10-19(20(23)24)27-17-7-4-15(22)5-8-17/h4-9,12,19,25H,10-11,13H2,1-3H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294177
PNG
(US9586900, Example 81)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(CC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C23H26F3NO4/c1-15-12-17(6-9-19(15)30-14-22(2,3)29)27-11-10-20(21(27)28)31-18-7-4-16(5-8-18)13-23(24,25)26/h4-9,12,20,29H,10-11,13-14H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294192
PNG
(US9586900, Example 96)
Show SMILES Cc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H28FNO6S/c1-18-15-22(9-12-25(18)34-16-23(30)17-36(2,32)33)29-14-13-26(27(29)31)35-24-10-5-20(6-11-24)19-3-7-21(28)8-4-19/h3-12,15,23,26,30H,13-14,16-17H2,1-2H3/t23-,26?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294119
PNG
(US9586900, Example 22)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO5/c1-24(2,27)15-29-20-11-8-18(14-22(20)28-3)25-13-12-21(23(25)26)30-19-9-6-17(7-10-19)16-4-5-16/h6-11,14,16,21,27H,4-5,12-13,15H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294102
PNG
(US9586900, Example 9)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC[C@@H](Oc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-21(2,28)13-30-17-9-6-15(12-19(17)29-3)26-11-10-18(20(26)27)31-16-7-4-14(5-8-16)22(23,24)25/h4-9,12,18,28H,10-11,13H2,1-3H3/t18-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294213
PNG
(US9586900, Example 117)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CC=C(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H22F3NO5/c1-14-12-15(4-9-18(14)29-13-21(2,3)28)26-11-10-19(20(26)27)30-16-5-7-17(8-6-16)31-22(23,24)25/h4-10,12,28H,11,13H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294172
PNG
(US9586900, Example 76)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C22H24F3NO4/c1-14-12-16(6-9-18(14)29-13-21(2,3)28)26-11-10-19(20(26)27)30-17-7-4-15(5-8-17)22(23,24)25/h4-9,12,19,28H,10-11,13H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294106
PNG
(US9586900, Example 12)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(I)cc2)C1=O
Show InChI InChI=1S/C21H24INO5/c1-21(2,25)13-27-17-9-6-15(12-19(17)26-3)23-11-10-18(20(23)24)28-16-7-4-14(22)5-8-16/h4-9,12,18,25H,10-11,13H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294208
PNG
(US9586900, Example 112)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C21H22F3NO5S/c1-14-13-16(5-8-18(14)29-11-12-31(2,27)28)25-10-9-19(20(25)26)30-17-6-3-15(4-7-17)21(22,23)24/h3-8,13,19H,9-12H2,1-2H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294161
PNG
(US9586900, Example 64)
Show SMILES COc1cc(ccc1OC[C@@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO7S/c1-30-23-13-18(7-10-21(23)31-14-19(26)15-33(2,28)29)25-12-11-22(24(25)27)32-20-8-5-17(6-9-20)16-3-4-16/h5-10,13,16,19,22,26H,3-4,11-12,14-15H2,1-2H3/t19-,22?/m1/s1
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294101
PNG
(US9586900, Example 8)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-21(2,28)13-30-17-9-6-15(12-19(17)29-3)26-11-10-18(20(26)27)31-16-7-4-14(5-8-16)22(23,24)25/h4-9,12,18,28H,10-11,13H2,1-3H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294128
PNG
(US9586900, Example 31)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(c(F)c2)-c2ccccc2F)C1=O
Show InChI InChI=1S/C27H27F2NO5/c1-27(2,32)16-34-23-11-8-17(14-25(23)33-3)30-13-12-24(26(30)31)35-18-9-10-20(22(29)15-18)19-6-4-5-7-21(19)28/h4-11,14-15,24,32H,12-13,16H2,1-3H3
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Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294185
PNG
(US9586900, Example 89)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccncc2)C1=O
Show InChI InChI=1S/C26H28N2O4/c1-18-16-21(6-9-23(18)31-17-26(2,3)30)28-15-12-24(25(28)29)32-22-7-4-19(5-8-22)20-10-13-27-14-11-20/h4-11,13-14,16,24,30H,12,15,17H2,1-3H3
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US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294152
PNG
(US9586900, Example 55)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(cc2)-c2cccc(F)c2)C1=O
Show InChI InChI=1S/C28H30FNO7S/c1-3-38(33,34)18-23(31)17-36-25-12-9-22(16-27(25)35-2)30-14-13-26(28(30)32)37-24-10-7-19(8-11-24)20-5-4-6-21(29)15-20/h4-12,15-16,23,26,31H,3,13-14,17-18H2,1-2H3/t23-,26?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294160
PNG
(US9586900, Example 63)
Show SMILES COc1cc(ccc1OC[C@@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H28FNO7S/c1-34-26-15-21(9-12-24(26)35-16-22(30)17-37(2,32)33)29-14-13-25(27(29)31)36-23-10-5-19(6-11-23)18-3-7-20(28)8-4-18/h3-12,15,22,25,30H,13-14,16-17H2,1-2H3/t22-,25?/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294199
PNG
(US9586900, Example 103)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C21H22F3NO6S/c1-14-13-15(3-8-18(14)29-11-12-32(2,27)28)25-10-9-19(20(25)26)30-16-4-6-17(7-5-16)31-21(22,23)24/h3-8,13,19H,9-12H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294196
PNG
(US9586900, Example 100)
Show SMILES Cc1cc(ccc1OC[C@@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO6S/c1-16-13-19(7-10-22(16)30-14-20(26)15-32(2,28)29)25-12-11-23(24(25)27)31-21-8-5-18(6-9-21)17-3-4-17/h5-10,13,17,20,23,26H,3-4,11-12,14-15H2,1-2H3/t20-,23?/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294120
PNG
(US9586900, Example 23)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(OC3CC3)cc2)C1=O
Show InChI InChI=1S/C24H29NO6/c1-24(2,27)15-29-20-11-4-16(14-22(20)28-3)25-13-12-21(23(25)26)31-19-9-7-18(8-10-19)30-17-5-6-17/h4,7-11,14,17,21,27H,5-6,12-13,15H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294184
PNG
(US9586900, Example 88)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(nc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H28N2O4/c1-18-15-20(9-12-23(18)31-17-26(2,3)30)28-14-13-24(25(28)29)32-21-10-11-22(27-16-21)19-7-5-4-6-8-19/h4-12,15-16,24,30H,13-14,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294209
PNG
(US9586900, Example 113)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CCC(Oc2ccc(cc2)-c2ccncc2)C1=O
Show InChI InChI=1S/C25H26N2O5S/c1-18-17-21(5-8-23(18)31-15-16-33(2,29)30)27-14-11-24(25(27)28)32-22-6-3-19(4-7-22)20-9-12-26-13-10-20/h3-10,12-13,17,24H,11,14-16H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294189
PNG
(US9586900, Example 93)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1C)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C25H31NO6S/c1-3-33(29,30)16-21(27)15-31-23-11-8-20(14-17(23)2)26-13-12-24(25(26)28)32-22-9-6-19(7-10-22)18-4-5-18/h6-11,14,18,21,24,27H,3-5,12-13,15-16H2,1-2H3/t21-,24?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294170
PNG
(US9586900, Example 74)
Show SMILES COc1cc(ccc1OCCS(=O)(=O)CC(C)(C)O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C26H33NO7S/c1-26(2,29)17-35(30,31)15-14-33-22-11-8-20(16-24(22)32-3)27-13-12-23(25(27)28)34-21-9-6-19(7-10-21)18-4-5-18/h6-11,16,18,23,29H,4-5,12-15,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294158
PNG
(US9586900, Example 61)
Show SMILES COc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H24F3NO8S/c1-31-20-11-14(3-8-18(20)32-12-15(27)13-35(2,29)30)26-10-9-19(21(26)28)33-16-4-6-17(7-5-16)34-22(23,24)25/h3-8,11,15,19,27H,9-10,12-13H2,1-2H3/t15-,19?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294133
PNG
(US9586900, Example 36)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2cccnc2)C1=O
Show InChI InChI=1S/C26H28N2O5/c1-26(2,30)17-32-22-11-8-20(15-24(22)31-3)28-14-12-23(25(28)29)33-21-9-6-18(7-10-21)19-5-4-13-27-16-19/h4-11,13,15-16,23,30H,12,14,17H2,1-3H3
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67n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294122
PNG
(US9586900, Example 25)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2Cl)C1=O
Show InChI InChI=1S/C27H28ClNO5/c1-27(2,31)17-33-23-13-10-19(16-25(23)32-3)29-15-14-24(26(29)30)34-20-11-8-18(9-12-20)21-6-4-5-7-22(21)28/h4-13,16,24,31H,14-15,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294153
PNG
(US9586900, Example 56)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(OC3CC3)cc2)C1=O
Show InChI InChI=1S/C25H31NO8S/c1-3-35(29,30)16-18(27)15-32-22-11-4-17(14-24(22)31-2)26-13-12-23(25(26)28)34-21-9-7-20(8-10-21)33-19-5-6-19/h4,7-11,14,18-19,23,27H,3,5-6,12-13,15-16H2,1-2H3/t18-,23?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294134
PNG
(US9586900, Example 37)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccncc2)C1=O
Show InChI InChI=1S/C26H28N2O5/c1-26(2,30)17-32-22-9-6-20(16-24(22)31-3)28-15-12-23(25(28)29)33-21-7-4-18(5-8-21)19-10-13-27-14-11-19/h4-11,13-14,16,23,30H,12,15,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294197
PNG
(US9586900, Example 101)
Show SMILES C[S+]([O-])CCOc1ccc(cc1C)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C21H22F3NO5S/c1-14-13-15(3-8-18(14)28-11-12-31(2)27)25-10-9-19(20(25)26)29-16-4-6-17(7-5-16)30-21(22,23)24/h3-8,13,19H,9-12H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294148
PNG
(US9586900, Example 51)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C23H26F3NO8S/c1-3-36(30,31)14-16(28)13-33-19-9-4-15(12-21(19)32-2)27-11-10-20(22(27)29)34-17-5-7-18(8-6-17)35-23(24,25)26/h4-9,12,16,20,28H,3,10-11,13-14H2,1-2H3/t16-,20?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294193
PNG
(US9586900, Example 97)
Show SMILES Cc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO6S/c1-16-13-19(7-10-22(16)30-14-20(26)15-32(2,28)29)25-12-11-23(24(25)27)31-21-8-5-18(6-9-21)17-3-4-17/h5-10,13,17,20,23,26H,3-4,11-12,14-15H2,1-2H3/t20-,23?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294132
PNG
(US9586900, Example 35)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(nc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H28N2O5/c1-26(2,30)17-32-22-12-9-19(15-24(22)31-3)28-14-13-23(25(28)29)33-20-10-11-21(27-16-20)18-7-5-4-6-8-18/h4-12,15-16,23,30H,13-14,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294123
PNG
(US9586900, Example 26)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2C)C1=O
Show InChI InChI=1S/C28H31NO5/c1-19-7-5-6-8-23(19)20-9-12-22(13-10-20)34-25-15-16-29(27(25)30)21-11-14-24(26(17-21)32-4)33-18-28(2,3)31/h5-14,17,25,31H,15-16,18H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294137
PNG
(US9586900, Example 40)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)N2CCC2)C1=O
Show InChI InChI=1S/C24H30N2O5/c1-24(2,28)16-30-20-10-7-18(15-22(20)29-3)26-14-11-21(23(26)27)31-19-8-5-17(6-9-19)25-12-4-13-25/h5-10,15,21,28H,4,11-14,16H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294126
PNG
(US9586900, Example 29)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(c(Cl)c2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H28ClNO5/c1-27(2,31)17-33-23-12-9-19(15-25(23)32-3)29-14-13-24(26(29)30)34-20-10-11-21(22(28)16-20)18-7-5-4-6-8-18/h4-12,15-16,24,31H,13-14,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294169
PNG
(US9586900, Example 73)
Show SMILES COc1cc(ccc1OCCS(C)(=O)=O)N1CC[C@H](Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C23H27NO6S/c1-28-22-15-18(7-10-20(22)29-13-14-31(2,26)27)24-12-11-21(23(24)25)30-19-8-5-17(6-9-19)16-3-4-16/h5-10,15-16,21H,3-4,11-14H2,1-2H3/t21-/m0/s1
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87n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294150
PNG
(US9586900, Example 53)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C23H26F3NO7S/c1-3-35(30,31)14-17(28)13-33-19-9-6-16(12-21(19)32-2)27-11-10-20(22(27)29)34-18-7-4-15(5-8-18)23(24,25)26/h4-9,12,17,20,28H,3,10-11,13-14H2,1-2H3/t17-,20?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294108
PNG
(US9586900, Example 14)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H24F3NO6/c1-21(2,28)13-30-17-9-4-14(12-19(17)29-3)26-11-10-18(20(26)27)31-15-5-7-16(8-6-15)32-22(23,24)25/h4-9,12,18,28H,10-11,13H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294179
PNG
(US9586900, Example 83)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CC[C@H](Oc2ccc(cc2)C2CC2)C1=O
Show InChI InChI=1S/C24H29NO4/c1-16-14-19(8-11-21(16)28-15-24(2,3)27)25-13-12-22(23(25)26)29-20-9-6-18(7-10-20)17-4-5-17/h6-11,14,17,22,27H,4-5,12-13,15H2,1-3H3/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294147
PNG
(US9586900, Example 50)
Show SMILES CCS(=O)(=O)C[C@H](O)COc1ccc(cc1OC)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C23H26F3NO8S/c1-3-36(30,31)14-16(28)13-33-19-9-4-15(12-21(19)32-2)27-11-10-20(22(27)29)34-17-5-7-18(8-6-17)35-23(24,25)26/h4-9,12,16,20,28H,3,10-11,13-14H2,1-2H3/t16-,20?/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294097
PNG
(US9586900, Example 4)
Show SMILES COc1cccc(OC2CCN(C2=O)c2ccc(OCC(C)(C)O)c(OC)c2)c1
Show InChI InChI=1S/C22H27NO6/c1-22(2,25)14-28-18-9-8-15(12-20(18)27-4)23-11-10-19(21(23)24)29-17-7-5-6-16(13-17)26-3/h5-9,12-13,19,25H,10-11,14H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294124
PNG
(US9586900, Example 27)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2OC)C1=O
Show InChI InChI=1S/C28H31NO6/c1-28(2,31)18-34-24-14-11-20(17-26(24)33-4)29-16-15-25(27(29)30)35-21-12-9-19(10-13-21)22-7-5-6-8-23(22)32-3/h5-14,17,25,31H,15-16,18H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294114
PNG
(US9586900, Example 17)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(OC(F)(F)F)cc2Cl)C1=O
Show InChI InChI=1S/C22H23ClF3NO6/c1-21(2,29)12-31-17-6-4-13(10-19(17)30-3)27-9-8-18(20(27)28)32-16-7-5-14(11-15(16)23)33-22(24,25)26/h4-7,10-11,18,29H,8-9,12H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294107
PNG
(US9586900, Example 13)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(C)(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C23H26F3NO6/c1-21(2,29)14-31-18-10-5-15(13-19(18)30-4)27-12-11-22(3,20(27)28)32-16-6-8-17(9-7-16)33-23(24,25)26/h5-10,13,29H,11-12,14H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294136
PNG
(US9586900, Example 39)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-n2ccnc2)C1=O
Show InChI InChI=1S/C24H27N3O5/c1-24(2,29)15-31-20-9-6-18(14-22(20)30-3)27-12-10-21(23(27)28)32-19-7-4-17(5-8-19)26-13-11-25-16-26/h4-9,11,13-14,16,21,29H,10,12,15H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294117
PNG
(US9586900, Example 20)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC[C@H](Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C27H29NO5/c1-27(2,30)18-32-23-14-11-21(17-25(23)31-3)28-16-15-24(26(28)29)33-22-12-9-20(10-13-22)19-7-5-4-6-8-19/h4-14,17,24,30H,15-16,18H2,1-3H3/t24-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294138
PNG
(US9586900, Example 41)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(Br)c(Cl)c2)C1=O
Show InChI InChI=1S/C21H23BrClNO5/c1-21(2,26)12-28-17-7-4-13(10-19(17)27-3)24-9-8-18(20(24)25)29-14-5-6-15(22)16(23)11-14/h4-7,10-11,18,26H,8-9,12H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294129
PNG
(US9586900, Example 32)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccncc2Cl)C1=O
Show InChI InChI=1S/C26H27ClN2O5/c1-26(2,31)16-33-22-9-6-18(14-24(22)32-3)29-13-11-23(25(29)30)34-19-7-4-17(5-8-19)20-10-12-28-15-21(20)27/h4-10,12,14-15,23,31H,11,13,16H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294202
PNG
(US9586900, Example 106)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CC[C@H](Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C26H27NO5S/c1-19-18-22(10-13-24(19)31-16-17-33(2,29)30)27-15-14-25(26(27)28)32-23-11-8-21(9-12-23)20-6-4-3-5-7-20/h3-13,18,25H,14-17H2,1-2H3/t25-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294098
PNG
(US9586900, Example 5)
Show SMILES COc1ccc(OC2CCN(C2=O)c2ccc(OCC(C)(C)O)c(OC)c2)cc1
Show InChI InChI=1S/C22H27NO6/c1-22(2,25)14-28-18-10-5-15(13-20(18)27-4)23-12-11-19(21(23)24)29-17-8-6-16(26-3)7-9-17/h5-10,13,19,25H,11-12,14H2,1-4H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294190
PNG
(US9586900, Example 94)
Show SMILES CCS(=O)(=O)C[C@@H](O)COc1ccc(cc1C)N1CCC(Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C23H26F3NO7S/c1-3-35(30,31)14-17(28)13-32-20-9-4-16(12-15(20)2)27-11-10-21(22(27)29)33-18-5-7-19(8-6-18)34-23(24,25)26/h4-9,12,17,21,28H,3,10-11,13-14H2,1-2H3/t17-,21?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294139
PNG
(US9586900, Example 42)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(Br)c(F)c2)C1=O
Show InChI InChI=1S/C21H23BrFNO5/c1-21(2,26)12-28-17-7-4-13(10-19(17)27-3)24-9-8-18(20(24)25)29-14-5-6-15(22)16(23)11-14/h4-7,10-11,18,26H,8-9,12H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294130
PNG
(US9586900, Example 33)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)N2CCOCC2)C1=O
Show InChI InChI=1S/C25H32N2O6/c1-25(2,29)17-32-21-9-6-19(16-23(21)30-3)27-11-10-22(24(27)28)33-20-7-4-18(5-8-20)26-12-14-31-15-13-26/h4-9,16,22,29H,10-15,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294125
PNG
(US9586900, Example 28)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cc2)-c2ccccc2C(F)(F)F)C1=O
Show InChI InChI=1S/C28H28F3NO5/c1-27(2,34)17-36-23-13-10-19(16-25(23)35-3)32-15-14-24(26(32)33)37-20-11-8-18(9-12-20)21-6-4-5-7-22(21)28(29,30)31/h4-13,16,24,34H,14-15,17H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294115
PNG
(US9586900, Example 18)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(OC(F)(F)F)c(F)c2)C1=O
Show InChI InChI=1S/C22H23F4NO6/c1-21(2,29)12-31-17-6-4-13(10-19(17)30-3)27-9-8-18(20(27)28)32-14-5-7-16(15(23)11-14)33-22(24,25)26/h4-7,10-11,18,29H,8-9,12H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294142
PNG
(US9586900, Example 45)
Show SMILES COc1cc(ccc1OC[C@H](O)C1CC1)N1CC[C@H](Oc2ccc(cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H29NO5/c1-32-27-17-22(11-14-25(27)33-18-24(30)21-7-8-21)29-16-15-26(28(29)31)34-23-12-9-20(10-13-23)19-5-3-2-4-6-19/h2-6,9-14,17,21,24,26,30H,7-8,15-16,18H2,1H3/t24-,26-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294194
PNG
(US9586900, Example 98)
Show SMILES Cc1cc(ccc1OC[C@H](O)CS(C)(=O)=O)N1CCC(Oc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C22H24F3NO6S/c1-14-11-16(5-8-19(14)31-12-17(27)13-33(2,29)30)26-10-9-20(21(26)28)32-18-6-3-15(4-7-18)22(23,24)25/h3-8,11,17,20,27H,9-10,12-13H2,1-2H3/t17-,20?/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294207
PNG
(US9586900, Example 111)
Show SMILES Cc1cc(ccc1OCCS(C)(=O)=O)N1CC[C@H](Oc2ccc(cc2)-c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H26FNO5S/c1-18-17-22(9-12-24(18)32-15-16-34(2,30)31)28-14-13-25(26(28)29)33-23-10-5-20(6-11-23)19-3-7-21(27)8-4-19/h3-12,17,25H,13-16H2,1-2H3/t25-/m0/s1
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1.74E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294096
PNG
(US9586900, Example 3)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C21H24ClNO5/c1-21(2,25)13-27-17-9-6-15(12-19(17)26-3)23-11-10-18(20(23)24)28-16-7-4-14(22)5-8-16/h4-9,12,18,25H,10-11,13H2,1-3H3
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2.06E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294111
PNG
(US9586900, Example 16)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC[C@H](Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H24F3NO6/c1-21(2,28)13-30-17-9-4-14(12-19(17)29-3)26-11-10-18(20(26)27)31-15-5-7-16(8-6-15)32-22(23,24)25/h4-9,12,18,28H,10-11,13H2,1-3H3/t18-/m0/s1
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2.34E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294069
PNG
(US9586900, Example 1)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccccc2Cl)C1=O
Show InChI InChI=1S/C21H24ClNO5/c1-21(2,25)13-27-17-9-8-14(12-19(17)26-3)23-11-10-18(20(23)24)28-16-7-5-4-6-15(16)22/h4-9,12,18,25H,10-11,13H2,1-3H3
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5.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294182
PNG
(US9586900, Example 86)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(cn2)C(F)(F)F)C1=O
Show InChI InChI=1S/C21H23F3N2O4/c1-13-10-15(5-6-16(13)29-12-20(2,3)28)26-9-8-17(19(26)27)30-18-7-4-14(11-25-18)21(22,23)24/h4-7,10-11,17,28H,8-9,12H2,1-3H3
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5.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294105
PNG
(US9586900, Example 11)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2cccc(OC(F)(F)F)c2)C1=O
Show InChI InChI=1S/C22H24F3NO6/c1-21(2,28)13-30-17-8-7-14(11-19(17)29-3)26-10-9-18(20(26)27)31-15-5-4-6-16(12-15)32-22(23,24)25/h4-8,11-12,18,28H,9-10,13H2,1-3H3
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5.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294174
PNG
(US9586900, Example 78)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CC[C@H](Oc2ccc(OC(F)(F)F)cc2)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-14-12-15(4-9-18(14)29-13-21(2,3)28)26-11-10-19(20(26)27)30-16-5-7-17(8-6-16)31-22(23,24)25/h4-9,12,19,28H,10-11,13H2,1-3H3/t19-/m0/s1
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6.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294103
PNG
((S)-1-(4-(2-Hydroxy-2-methylpropoxy)-3-methoxyphen...)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CC[C@H](Oc2ccc(cc2)C(F)(F)F)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-21(2,28)13-30-17-9-6-15(12-19(17)29-3)26-11-10-18(20(26)27)31-16-7-4-14(5-8-16)22(23,24)25/h4-9,12,18,28H,10-11,13H2,1-3H3/t18-/m0/s1
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6.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294100
PNG
(US9586900, Example 7)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2cccc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-21(2,28)13-30-17-8-7-15(12-19(17)29-3)26-10-9-18(20(26)27)31-16-6-4-5-14(11-16)22(23,24)25/h4-8,11-12,18,28H,9-10,13H2,1-3H3
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6.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294183
PNG
(US9586900, Example 87)
Show SMILES Cc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccc(Br)nc2)C1=O
Show InChI InChI=1S/C20H23BrN2O4/c1-13-10-14(4-6-16(13)26-12-20(2,3)25)23-9-8-17(19(23)24)27-15-5-7-18(21)22-11-15/h4-7,10-11,17,25H,8-9,12H2,1-3H3
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7.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294099
PNG
(US9586900, Example 6)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2ccccc2C(F)(F)F)C1=O
Show InChI InChI=1S/C22H24F3NO5/c1-21(2,28)13-30-17-9-8-14(12-19(17)29-3)26-11-10-18(20(26)27)31-16-7-5-4-6-15(16)22(23,24)25/h4-9,12,18,28H,10-11,13H2,1-3H3
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7.00E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM294095
PNG
(US9586900, Example 2)
Show SMILES COc1cc(ccc1OCC(C)(C)O)N1CCC(Oc2cccc(Cl)c2)C1=O
Show InChI InChI=1S/C21H24ClNO5/c1-21(2,25)13-27-17-8-7-15(12-19(17)26-3)23-10-9-18(20(23)24)28-16-6-4-5-14(22)11-16/h4-8,11-12,18,25H,9-10,13H2,1-3H3
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1.00E+4n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...


US Patent US9586900 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%