BindingDB logo
myBDB logout

Patent code US9592230

Compile Data Set for Download or QSAR
Found 125 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398017
PNG
(CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C20H21N5/c1-14-9-10-15(2)25-20(14)22-18(23-25)11-12-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-10,13H,11-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.320n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47287
PNG
(US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1-propyl-1H...)
Show SMILES CCCn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H24N6/c1-4-12-26-14-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(2)13-16(3)27(21)25-19/h5-9,13-14H,4,10-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.690n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156359
PNG
(US9018217, 8-Ethyl-5-methyl-2-[2-(1-methyl-4-pheny...)
Show SMILES CCc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C21H23N5/c1-4-16-11-10-15(2)26-21(16)23-19(24-26)12-13-20-22-18(14-25(20)3)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.930n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47296
PNG
(US9018217, 8-Ethyl-5-methyl-2-(2-(1-methyl-4-pheny...)
Show SMILES CCc1cnc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C20H22N6/c1-4-15-12-21-14(2)26-20(15)23-18(24-26)10-11-19-22-17(13-25(19)3)16-8-6-5-7-9-16/h5-9,12-13H,4,10-11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156347
PNG
(US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...)
Show SMILES CC(C)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C22H26N6/c1-15(2)13-27-14-19(18-8-6-5-7-9-18)24-21(27)11-10-20-25-22-23-16(3)12-17(4)28(22)26-20/h5-9,12,14-15H,10-11,13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.30n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM299447
PNG
(US9592230, 5-Methyl-2-{2-[4-phenyl-1-(2-piperidin-...)
Show SMILES Cc1cccc2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nn12
Show InChI InChI=1S/C25H30N6/c1-20-9-8-12-25-27-23(28-31(20)25)13-14-24-26-22(21-10-4-2-5-11-21)19-30(24)18-17-29-15-6-3-7-16-29/h2,4-5,8-12,19H,3,6-7,13-18H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156350
PNG
(US9018217, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C24H29N7O/c1-18-16-19(2)31-24(25-18)27-22(28-31)8-9-23-26-21(20-6-4-3-5-7-20)17-30(23)11-10-29-12-14-32-15-13-29/h3-7,16-17H,8-15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.40n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156337
PNG
(US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...)
Show SMILES CC(C)Cn1cc(nc1CCc1nc2cccc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-16(2)14-26-15-19(18-9-5-4-6-10-18)23-21(26)13-12-20-24-22-11-7-8-17(3)27(22)25-20/h4-11,15-16H,12-14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.60n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398014
PNG
(CHEMBL2180414 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3ccccc3)nn12
Show InChI InChI=1S/C19H20N6/c1-13-11-20-14(2)19-22-17(23-25(13)19)9-10-18-21-16(12-24(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.80n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156352
PNG
(US9018217, 8-methoxy-5-methyl-2-(2-(1-methyl-4-phe...)
Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C20H21N5O/c1-14-9-10-17(26-3)20-22-18(23-25(14)20)11-12-19-21-16(13-24(19)2)15-7-5-4-6-8-15/h4-10,13H,11-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.5n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156346
PNG
(US9018217, 5,7-Dimethyl-2-{2-[4-phenyl-1-(2-piperi...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C25H31N7/c1-19-17-20(2)32-25(26-19)28-23(29-32)11-12-24-27-22(21-9-5-3-6-10-21)18-31(24)16-15-30-13-7-4-8-14-30/h3,5-6,9-10,17-18H,4,7-8,11-16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.70n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47278
PNG
(US9018217, 1-Methyl-3-(2-[2-[2-(5-methyl-[1,2,4]tr...)
Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3cccc(C)n3n2)-c2ccccc2)C1=O
Show InChI InChI=1S/C24H27N7O/c1-18-7-6-10-23-26-21(27-31(18)23)11-12-22-25-20(19-8-4-3-5-9-19)17-30(22)16-15-29-14-13-28(2)24(29)32/h3-10,17H,11-16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.80n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156342
PNG
(US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...)
Show SMILES Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C24H22N6/c1-17-15-21(19-11-7-4-8-12-19)30-24(25-17)27-22(28-30)13-14-23-26-20(16-29(23)2)18-9-5-3-6-10-18/h3-12,15-16H,13-14H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.80n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156333
PNG
(US9018217, 5-Methyl-2-[2-(4-phenyl-1H-imidazol-2-y...)
Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3ccccc3)nn12
Show InChI InChI=1S/C18H17N5/c1-13-6-5-9-18-21-17(22-23(13)18)11-10-16-19-12-15(20-16)14-7-3-2-4-8-14/h2-9,12H,10-11H2,1H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.80n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156348
PNG
(US9018217, 2-[2-(1-Isopropyl-4-phenyl-1H-imidazol-...)
Show SMILES CC(C)n1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H24N6/c1-14(2)26-13-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(3)12-16(4)27(21)25-19/h5-9,12-14H,10-11H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.40n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156354
PNG
(US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...)
Show SMILES CCCc1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12
Show InChI InChI=1S/C21H24N6/c1-4-8-17-13-15(2)22-21-24-19(25-27(17)21)11-12-20-23-18(14-26(20)3)16-9-6-5-7-10-16/h5-7,9-10,13-14H,4,8,11-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.60n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156334
PNG
(US9018217, 2-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl...)
Show SMILES CC(C)Cn1cc(nc1SCc1nc2nc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H24N6S/c1-14(2)11-26-12-18(17-8-6-5-7-9-17)23-21(26)28-13-19-24-20-22-15(3)10-16(4)27(20)25-19/h5-10,12,14H,11,13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.20n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47285
PNG
(US9018217, 1-(2-[2-[2-(5,7-Dimethyl-[1,2,4]triazol...)
Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3nc(C)cc(C)n3n2)-c2ccccc2)C1=O
Show InChI InChI=1S/C24H28N8O/c1-17-15-18(2)32-23(25-17)27-21(28-32)9-10-22-26-20(19-7-5-4-6-8-19)16-31(22)14-13-30-12-11-29(3)24(30)33/h4-8,15-16H,9-14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156356
PNG
(US9018217, 7-Isopropyl-5-methyl-2-[2-(1-methyl-4-p...)
Show SMILES CC(C)c1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12
Show InChI InChI=1S/C21H24N6/c1-14(2)18-12-15(3)22-21-24-19(25-27(18)21)10-11-20-23-17(13-26(20)4)16-8-6-5-7-9-16/h5-9,12-14H,10-11H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.80n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156335
PNG
(US9018217, 5,7-Dimethyl-2-[1-(2-morpholin-4-yl-eth...)
Show SMILES Cc1cc(C)n2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C23H27N7OS/c1-17-14-18(2)30-22(24-17)26-21(27-30)16-32-23-25-20(19-6-4-3-5-7-19)15-29(23)9-8-28-10-12-31-13-11-28/h3-7,14-15H,8-13,16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156330
PNG
(US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1H-imidazol...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(c[nH]3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C18H18N6/c1-12-10-13(2)24-18(20-12)22-17(23-24)9-8-16-19-11-15(21-16)14-6-4-3-5-7-14/h3-7,10-11H,8-9H2,1-2H3,(H,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.30n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156255
PNG
(US9018217, 5,7-Dimethyl-2-[1-(3-methyl-butyl)-4-ph...)
Show SMILES CC(C)CCn1cc(nc1SCc1cn2c(C)cc(C)nc2n1)-c1ccccc1
Show InChI InChI=1S/C23H27N5S/c1-16(2)10-11-27-14-21(19-8-6-5-7-9-19)26-23(27)29-15-20-13-28-18(4)12-17(3)24-22(28)25-20/h5-9,12-14,16H,10-11,15H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.40n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156351
PNG
(US9018217, (S)-1-{2-[2-(5,7-Dimethyl-[1,2,4]triazo...)
Show SMILES C[C@H](O)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H24N6O/c1-14-11-15(2)27-21(22-14)24-19(25-27)9-10-20-23-18(13-26(20)12-16(3)28)17-7-5-4-6-8-17/h4-8,11,13,16,28H,9-10,12H2,1-3H3/t16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.5n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156324
PNG
(US9018217, 4-(2-(2-(2-(5,7-dimethyl-[1,2,4]triazol...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2c1
Show InChI InChI=1S/C25H30N6O/c1-19-16-20(2)31-25(17-19)27-23(28-31)8-9-24-26-22(21-6-4-3-5-7-21)18-30(24)11-10-29-12-14-32-15-13-29/h3-7,16-18H,8-15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156336
PNG
(US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...)
Show SMILES Cc1cc(N2CCOCC2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C22H25N7O/c1-16-14-21(28-10-12-30-13-11-28)29-22(23-16)25-19(26-29)8-9-20-24-18(15-27(20)2)17-6-4-3-5-7-17/h3-7,14-15H,8-13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.90n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398016
PNG
(CHEMBL2180412 | US9018217, 5,8-Dimethyl-2-[2-(1-me...)
Show SMILES Cc1cnc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C19H20N6/c1-13-11-20-14(2)25-19(13)22-17(23-25)9-10-18-21-16(12-24(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.20n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47282
PNG
(US9018217, Diisopropyl-(2-[2-[2-(5-methyl-[1,2,4]t...)
Show SMILES CC(C)N(CCn1cc(nc1CCc1nc2cccc(C)n2n1)-c1ccccc1)C(C)C
Show InChI InChI=1S/C26H34N6/c1-19(2)31(20(3)4)17-16-30-18-23(22-11-7-6-8-12-22)27-25(30)15-14-24-28-26-13-9-10-21(5)32(26)29-24/h6-13,18-20H,14-17H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.30n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156344
PNG
(US9018217, 5-Ethyl-2-(1-methyl-4-phenyl-1H-imidazo...)
Show SMILES CCc1cccc2nc(CSc3nc(cn3C)-c3ccccc3)nn12
Show InChI InChI=1S/C19H19N5S/c1-3-15-10-7-11-18-21-17(22-24(15)18)13-25-19-20-16(12-23(19)2)14-8-5-4-6-9-14/h4-12H,3,13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.5n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156322
PNG
(US9018217, 5-Methyl-2-{2-[1-(2-morpholin-4-yl-ethy...)
Show SMILES Cc1cccc2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nn12
Show InChI InChI=1S/C24H28N6O/c1-19-6-5-9-24-26-22(27-30(19)24)10-11-23-25-21(20-7-3-2-4-8-20)18-29(23)13-12-28-14-16-31-17-15-28/h2-9,18H,10-17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.10n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47276
PNG
(US9018217, 1-Methyl-3-(2-[2-[2-(5-methyl-[1,2,4]tr...)
Show SMILES Cc1cccn2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc12
Show InChI InChI=1S/C24H28N6O/c1-19-6-5-11-30-24(19)26-22(27-30)9-10-23-25-21(20-7-3-2-4-8-20)18-29(23)13-12-28-14-16-31-17-15-28/h2-8,11,18H,9-10,12-17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.10n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156349
PNG
(US9018217, (2-{2-[2-(5,7-Dimethyl-[1,2,4]triazolo[...)
Show SMILES CC(C)N(CCn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1)C(C)C
Show InChI InChI=1S/C26H35N7/c1-18(2)32(19(3)4)15-14-31-17-23(22-10-8-7-9-11-22)28-25(31)13-12-24-29-26-27-20(5)16-21(6)33(26)30-24/h7-11,16-19H,12-15H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.70n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156256
PNG
(US9018217, 5,7-Dimethyl-2-(4-phenyl-1-propyl-1H-im...)
Show SMILES CCCn1cc(nc1SCc1cn2c(C)cc(C)nc2n1)-c1ccccc1
Show InChI InChI=1S/C21H23N5S/c1-4-10-25-13-19(17-8-6-5-7-9-17)24-21(25)27-14-18-12-26-16(3)11-15(2)22-20(26)23-18/h5-9,11-13H,4,10,14H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.10n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47289
PNG
(US9018217, (R)-1-[2-[2-(5,7-Dimethyl-[1,2,4]triazo...)
Show SMILES C[C@@H](O)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H24N6O/c1-14-11-15(2)27-21(22-14)24-19(25-27)9-10-20-23-18(13-26(20)12-16(3)28)17-7-5-4-6-8-17/h4-8,11,13,16,28H,9-10,12H2,1-3H3/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156327
PNG
(US9018217, 5,7-Dimethyl-2-[2-(1-methyl-4-phenyl-1H...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C19H20N6/c1-13-11-14(2)25-19(20-13)22-17(23-25)9-10-18-21-16(12-24(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156320
PNG
(US9018217, 8-Methyl-2-[2-(1-methyl-4-phenyl-1H-Imi...)
Show SMILES Cc1cccn2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C19H19N5/c1-14-7-6-12-24-19(14)21-17(22-24)10-11-18-20-16(13-23(18)2)15-8-4-3-5-9-15/h3-9,12-13H,10-11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156257
PNG
(US9018217, 2-(1-Cyclopropylmethyl-4-phenyl-1H-imid...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3CC3CC3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C22H23N5S/c1-15-10-16(2)27-12-19(24-21(27)23-15)14-28-22-25-20(18-6-4-3-5-7-18)13-26(22)11-17-8-9-17/h3-7,10,12-13,17H,8-9,11,14H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47288
PNG
(US9018217, 1-[2-[2-(5,7-Dimethyl-[1,2,4]triazolo[1...)
Show SMILES CC(O)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H24N6O/c1-14-11-15(2)27-21(22-14)24-19(25-27)9-10-20-23-18(13-26(20)12-16(3)28)17-7-5-4-6-8-17/h4-8,11,13,16,28H,9-10,12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 13n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156321
PNG
(US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...)
Show SMILES Cc1cccc2nc(CCc3nc(cn3C)-c3ccccc3)nn12
Show InChI InChI=1S/C19H19N5/c1-14-7-6-10-19-21-17(22-24(14)19)11-12-18-20-16(13-23(18)2)15-8-4-3-5-9-15/h3-10,13H,11-12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156358
PNG
(US9018217, {5-Methyl-2-[2-(1-methyl-4-phenyl-1H-im...)
Show SMILES Cc1cc(CO)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C19H20N6O/c1-13-10-15(12-26)25-19(20-13)22-17(23-25)8-9-18-21-16(11-24(18)2)14-6-4-3-5-7-14/h3-7,10-11,26H,8-9,12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156341
PNG
(US9018217, 5,6,7-Trimethyl-2-[2-(1-methyl-4-phenyl...)
Show SMILES Cc1nc2nc(CCc3nc(cn3C)-c3ccccc3)nn2c(C)c1C
Show InChI InChI=1S/C20H22N6/c1-13-14(2)21-20-23-18(24-26(20)15(13)3)10-11-19-22-17(12-25(19)4)16-8-6-5-7-9-16/h5-9,12H,10-11H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156326
PNG
(US9018217, 5,7-dimethyl-2-(2-(4-phenyl-1H-imidazol...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(c[nH]3)-c3ccccc3)nc2c1
Show InChI InChI=1S/C19H19N5/c1-13-10-14(2)24-19(11-13)22-18(23-24)9-8-17-20-12-16(21-17)15-6-4-3-5-7-15/h3-7,10-12H,8-9H2,1-2H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM50398015
PNG
(CHEMBL2180413 | US9018217, 5,7-dimethyl-2-(2-(1-me...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2c1
Show InChI InChI=1S/C20H21N5/c1-14-11-15(2)25-20(12-14)22-18(23-25)9-10-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-8,11-13H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47274
PNG
(US9018217, 4-(2-(2-((8-chloro-[1,2,4]triazolo[1,5-...)
Show SMILES Clc1cccn2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc12
Show InChI InChI=1S/C22H23ClN6OS/c23-18-7-4-8-29-21(18)25-20(26-29)16-31-22-24-19(17-5-2-1-3-6-17)15-28(22)10-9-27-11-13-30-14-12-27/h1-8,15H,9-14,16H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156325
PNG
(US9018217, 6,8-dimethyl-2-(2-(1-methyl-4-phenyl-1H...)
Show SMILES Cc1cc(C)c2nc(CCc3nc(cn3C)-c3ccccc3)nn2c1
Show InChI InChI=1S/C20H21N5/c1-14-11-15(2)20-22-18(23-25(20)12-14)9-10-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-8,11-13H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 19n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156258
PNG
(US9018217, 5,7-dimethyl-2((1-methyl-4-phenyl-1H-im...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C19H19N5S/c1-13-9-14(2)24-10-16(21-18(24)20-13)12-25-19-22-17(11-23(19)3)15-7-5-4-6-8-15/h4-11H,12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 20n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156259
PNG
(US9018217, 5,7-Dimethyl-2-[1-(2-morpholin-4-yl-eth...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C24H28N6OS/c1-18-14-19(2)30-15-21(26-23(30)25-18)17-32-24-27-22(20-6-4-3-5-7-20)16-29(24)9-8-28-10-12-31-13-11-28/h3-7,14-16H,8-13,17H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 22n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156338
PNG
(US9018217, 2-[2-(1-Isopropyl-4-phenyl-1H-imidazol-...)
Show SMILES CC(C)n1cc(nc1CCc1nc2cccc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H23N5/c1-15(2)25-14-18(17-9-5-4-6-10-17)22-20(25)13-12-19-23-21-11-7-8-16(3)26(21)24-19/h4-11,14-15H,12-13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 23n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156331
PNG
(US9018217, 5,7-Dimethyl-2-(4-phenyl-1H-imidazol-2-...)
Show SMILES Cc1cc(C)n2nc(CSc3nc(c[nH]3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C17H16N6S/c1-11-8-12(2)23-16(19-11)21-15(22-23)10-24-17-18-9-14(20-17)13-6-4-3-5-7-13/h3-9H,10H2,1-2H3,(H,18,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM299441
PNG
(US9592230, 5-Methyl-2-{2-[4-phenyl-1-(3-piperidin-...)
Show SMILES Cc1cccc2nc(CCc3nc(cn3CCCN3CCCCC3)-c3ccccc3)nn12
Show InChI InChI=1S/C26H32N6/c1-21-10-8-13-26-28-24(29-32(21)26)14-15-25-27-23(22-11-4-2-5-12-22)20-31(25)19-9-18-30-16-6-3-7-17-30/h2,4-5,8,10-13,20H,3,6-7,9,14-19H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 25n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156340
PNG
(US9018217, 1-{2-[2-(5,7-Dimethyl-[1,2,4]triazolo[1...)
Show SMILES CN1CCN(CCn2cc(nc2SCc2nc3nc(C)cc(C)n3n2)-c2ccccc2)C1=O
Show InChI InChI=1S/C23H26N8OS/c1-16-13-17(2)31-21(24-16)26-20(27-31)15-33-22-25-19(18-7-5-4-6-8-18)14-30(22)12-11-29-10-9-28(3)23(29)32/h4-8,13-14H,9-12,15H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156332
PNG
(US9018217, 5,7-Dimethyl-2-(1-methyl-4-phenyl-1H-im...)
Show SMILES Cc1cc(C)n2nc(CSc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C18H18N6S/c1-12-9-13(2)24-17(19-12)21-16(22-24)11-25-18-20-15(10-23(18)3)14-7-5-4-6-8-14/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156329
PNG
(US9018217, 5,7-dimethyl-2-(2-(4-phenyl-1-propyl-1H...)
Show SMILES CCCn1cc(nc1CCc1nc2cc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C22H25N5/c1-4-12-26-15-19(18-8-6-5-7-9-18)23-21(26)11-10-20-24-22-14-16(2)13-17(3)27(22)25-20/h5-9,13-15H,4,10-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 26n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156260
PNG
(US9018217, 5,7-Dimethyl-2-(1-methyl-4-phenyl-1H-im...)
Show SMILES Cc1cc(C)n2nc(CSc3nc(cn3C)-c3ccccc3)nc2c1
Show InChI InChI=1S/C19H19N5S/c1-13-9-14(2)24-18(10-13)21-17(22-24)12-25-19-20-16(11-23(19)3)15-7-5-4-6-8-15/h4-11H,12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 26n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156357
PNG
(US9018217, 7-Methoxy-5,8-dimethyl-2-[2-(1-methyl-4...)
Show SMILES COc1nc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2c1C
Show InChI InChI=1S/C20H22N6O/c1-13-19-23-17(24-26(19)14(2)21-20(13)27-4)10-11-18-22-16(12-25(18)3)15-8-6-5-7-9-15/h5-9,12H,10-11H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 29n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47290
PNG
(US9018217, 1-{2-[2-(5,7-Dimethyl]-[1,2,4]triazolo[...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CC(C)(C)O)-c3ccccc3)nc2n1
Show InChI InChI=1S/C22H26N6O/c1-15-12-16(2)28-21(23-15)25-19(26-28)10-11-20-24-18(17-8-6-5-7-9-17)13-27(20)14-22(3,4)29/h5-9,12-13,29H,10-11,14H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 29n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47294
PNG
(US9018217, 2-{2-[4-(2-Methoxy-phenyl)-1-methyl-1H,...)
Show SMILES COc1ccccc1-c1cn(C)c(CCc2nc3nc(C)cc(C)n3n2)n1
Show InChI InChI=1S/C20H22N6O/c1-13-11-14(2)26-20(21-13)23-18(24-26)9-10-19-22-16(12-25(19)3)15-7-5-6-8-17(15)27-4/h5-8,11-12H,9-10H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 32n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156323
PNG
(US9018217, 4-(2-(2-((5-chloro-[1,2,4]triazolo[1,5-...)
Show SMILES Clc1cccc2nc(CSc3nc(cn3CCN3CCOCC3)-c3ccccc3)nn12
Show InChI InChI=1S/C22H23ClN6OS/c23-19-7-4-8-21-25-20(26-29(19)21)16-31-22-24-18(17-5-2-1-3-6-17)15-28(22)10-9-27-11-13-30-14-12-27/h1-8,15H,9-14,16H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 33n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156360
PNG
(US9018217, 5,8-Dimethoxy-2-[2-(1-methyl-4-phenyl-1...)
Show SMILES COc1ccc(OC)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C20H21N5O2/c1-24-13-15(14-7-5-4-6-8-14)21-18(24)11-10-17-22-20-16(26-2)9-12-19(27-3)25(20)23-17/h4-9,12-13H,10-11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156261
PNG
(US9018217, 2-(1-Cyclopropylmethyl-4-phenyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3CC3CC3)-c3ccccc3)nc2c1
Show InChI InChI=1S/C22H23N5S/c1-15-10-16(2)27-20(11-15)24-22(25-27)28-14-21-23-19(18-6-4-3-5-7-18)13-26(21)12-17-8-9-17/h3-7,10-11,13,17H,8-9,12,14H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 34n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156328
PNG
(US9018217, 2-(2-(1-ethyl-4-phenyl-1H-imidazol-2-yl...)
Show SMILES CCn1cc(nc1CCc1nc2cc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H23N5/c1-4-25-14-18(17-8-6-5-7-9-17)22-20(25)11-10-19-23-21-13-15(2)12-16(3)26(21)24-19/h5-9,12-14H,4,10-11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 36n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156339
PNG
(US9018217, 8-Methoxy-2-(1-methyl-4-phenyl-1H-imida...)
Show SMILES COc1cccn2nc(CSc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C18H17N5OS/c1-22-11-14(13-7-4-3-5-8-13)19-18(22)25-12-16-20-17-15(24-2)9-6-10-23(17)21-16/h3-11H,12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156262
PNG
(US9018217, 2-(1-Benzyl-4-phenyl-1H-imidazol-2-ylme...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3Cc3ccccc3)-c3ccccc3)nc2c1
Show InChI InChI=1S/C25H23N5S/c1-18-13-19(2)30-23(14-18)27-25(28-30)31-17-24-26-22(21-11-7-4-8-12-21)16-29(24)15-20-9-5-3-6-10-20/h3-14,16H,15,17H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 48n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156263
PNG
(US9018217, [2-(5,7-Dimethyl-imidazo[1,2-a]pyrimidi...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3CC#N)-c3ccccc3)nc2n1
Show InChI InChI=1S/C20H18N6S/c1-14-10-15(2)26-11-17(23-19(26)22-14)13-27-20-24-18(12-25(20)9-8-21)16-6-4-3-5-7-16/h3-7,10-12H,9,13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 52n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156264
PNG
(US9018217, 5,7-Dimethyl-2-[4-phenyl-1-(tetrahydro-...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3CC3CCOCC3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C24H27N5OS/c1-17-12-18(2)29-14-21(26-23(29)25-17)16-31-24-27-22(20-6-4-3-5-7-20)15-28(24)13-19-8-10-30-11-9-19/h3-7,12,14-15,19H,8-11,13,16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 59n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156265
PNG
(US9018217, 5,7-Dimethyl-2-(1-methyl-4-phenyl-1H-im...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3ccccc3)nc2c1
Show InChI InChI=1S/C19H19N5S/c1-13-9-14(2)24-17(10-13)21-19(22-24)25-12-18-20-16(11-23(18)3)15-7-5-4-6-8-15/h4-11H,12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 61n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156266
PNG
(US9018217, 5,7-Dimethyl-2-(4-phenyl-1H-imidazol-2-...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(c[nH]3)-c3ccccc3)nc2c1
Show InChI InChI=1S/C18H17N5S/c1-12-8-13(2)23-17(9-12)21-18(22-23)24-11-16-19-10-15(20-16)14-6-4-3-5-7-14/h3-10H,11H2,1-2H3,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 64n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156267
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cn1cc(nc1SCc1cn2c(cccc2n1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C19H15F3N4S/c1-25-11-15(13-6-3-2-4-7-13)24-18(25)27-12-14-10-26-16(19(20,21)22)8-5-9-17(26)23-14/h2-11H,12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 66n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156269
PNG
(US9018217, 5,7-Dimethyl-2-[2-(1-methyl-4-phenyl-1H...)
Show SMILES Cc1cc(C)n2cc(CCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C20H21N5/c1-14-11-15(2)25-12-17(22-20(25)21-14)9-10-19-23-18(13-24(19)3)16-7-5-4-6-8-16/h4-8,11-13H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 68n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156268
PNG
(US9018217, 2-(1-Ethyl-4-phenyl-1H-imidazol-2-ylmet...)
Show SMILES CCn1cc(nc1CSc1nc2cc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C20H21N5S/c1-4-24-12-17(16-8-6-5-7-9-16)21-19(24)13-26-20-22-18-11-14(2)10-15(3)25(18)23-20/h5-12H,4,13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 68n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156270
PNG
(US9018217, [2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3CC#N)-c3ccccc3)nc2c1
Show InChI InChI=1S/C20H18N6S/c1-14-10-15(2)26-18(11-14)23-20(24-26)27-13-19-22-17(12-25(19)9-8-21)16-6-4-3-5-7-16/h3-7,10-12H,9,13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 69n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156271
PNG
(US9018217, 2-(1-Isopropyl-4-phenyl-1H-imidazol-2-y...)
Show SMILES CC(C)n1cc(nc1CSc1nc2cc(C)cc(C)n2n1)-c1ccccc1
Show InChI InChI=1S/C21H23N5S/c1-14(2)25-12-18(17-8-6-5-7-9-17)22-20(25)13-27-21-23-19-11-15(3)10-16(4)26(19)24-21/h5-12,14H,13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 70n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156272
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylme...)
Show SMILES Cn1cc(nc1CSc1nc2ccccn2n1)-c1ccccc1
Show InChI InChI=1S/C17H15N5S/c1-21-11-14(13-7-3-2-4-8-13)18-16(21)12-23-17-19-15-9-5-6-10-22(15)20-17/h2-11H,12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 75n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM47292
PNG
(US9018217, 2-{2-[4-(2,4-Difluoro-phenyl)-1-methyl-...)
Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3C)-c3ccc(F)cc3F)nc2n1
Show InChI InChI=1S/C19H18F2N6/c1-11-8-12(2)27-19(22-11)24-17(25-27)6-7-18-23-16(10-26(18)3)14-5-4-13(20)9-15(14)21/h4-5,8-10H,6-7H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 79n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156343
PNG
(US9018217, 2-[4-(3-Methoxy-phenyl)-1-methyl-1H-imi...)
Show SMILES COc1cccc(c1)-c1cn(C)c(CSc2nc3nc(C)cc(C)n3n2)n1
Show InChI InChI=1S/C19H20N6OS/c1-12-8-13(2)25-18(20-12)22-19(23-25)27-11-17-21-16(10-24(17)3)14-6-5-7-15(9-14)26-4/h5-10H,11H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 80n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156273
PNG
(US9018217, 2-(1-Benzyl-4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3Cc3ccccc3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C25H23N5S/c1-18-13-19(2)30-15-22(27-24(30)26-18)17-31-25-28-23(21-11-7-4-8-12-21)16-29(25)14-20-9-5-3-6-10-20/h3-13,15-16H,14,17H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 84n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156274
PNG
(US9018217, 2-(4-Phenyl-1H-imidazol-2-ylmethylsulfa...)
Show SMILES C(Sc1nc2ccccn2n1)c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C16H13N5S/c1-2-6-12(7-3-1)13-10-17-14(18-13)11-22-16-19-15-8-4-5-9-21(15)20-16/h1-10H,11H2,(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 87n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156275
PNG
(US9018217, 6-Chloro-8-methyl-2-(1-methyl-4-phenyl-...)
Show SMILES Cc1cc(Cl)cn2nc(SCc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C18H16ClN5S/c1-12-8-14(19)9-24-17(12)21-18(22-24)25-11-16-20-15(10-23(16)2)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 91n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156277
PNG
(US9018217, 2-(1-Isopropyl-4-phenyl-1H-imidazol-2-y...)
Show SMILES CC(C)n1cc(nc1SCc1cn2c(C)cc(C)nc2n1)-c1ccccc1
Show InChI InChI=1S/C21H23N5S/c1-14(2)25-12-19(17-8-6-5-7-9-17)24-21(25)27-13-18-11-26-16(4)10-15(3)22-20(26)23-18/h5-12,14H,13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 92n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM299354
PNG
(US9592230, trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4...)
Show SMILES Cc1cc(C)n2cc(C=Cc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C20H19N5/c1-14-11-15(2)25-12-17(22-20(25)21-14)9-10-19-23-18(13-24(19)3)16-7-5-4-6-8-16/h4-13H,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 92n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156278
PNG
(US9018217, 2-[4-(3-Fluoro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3cccc(F)c3)nc2c1
Show InChI InChI=1S/C19H18FN5S/c1-12-7-13(2)25-17(8-12)22-19(23-25)26-11-18-21-16(10-24(18)3)14-5-4-6-15(20)9-14/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 100n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156279
PNG
(US9018217, 2-(1-Ethyl-4-phenyl-1H-imidazol-2-ylsul...)
Show SMILES CCn1cc(nc1SCc1cn2c(C)cc(C)nc2n1)-c1ccccc1
Show InChI InChI=1S/C20H21N5S/c1-4-24-12-18(16-8-6-5-7-9-16)23-20(24)26-13-17-11-25-15(3)10-14(2)21-19(25)22-17/h5-12H,4,13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 100n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156280
PNG
(US9018217, 2-(5,7-Dimethyl-imidazol[1,2-a]pyrimidi...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3N)-c3ccccc3)nc2n1
Show InChI InChI=1S/C18H18N6S/c1-12-8-13(2)23-9-15(21-17(23)20-12)11-25-18-22-16(10-24(18)19)14-6-4-3-5-7-14/h3-10H,11,19H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156353
PNG
(US9018217, 8-fluoro-2-(2-(1-methyl-4-phenyl-1H-imi...)
Show SMILES Cn1cc(nc1CCc1nc2c(F)cccn2n1)-c1ccccc1
Show InChI InChI=1S/C18H16FN5/c1-23-12-15(13-6-3-2-4-7-13)20-17(23)10-9-16-21-18-14(19)8-5-11-24(18)22-16/h2-8,11-12H,9-10H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 120n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156345
PNG
(US9018217, 5,7-Dimethyl-2-(1-methyl-4-phenyl-1H-im...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3ccccc3)nc2n1
Show InChI InChI=1S/C18H18N6S/c1-12-9-13(2)24-17(19-12)21-18(22-24)25-11-16-20-15(10-23(16)3)14-7-5-4-6-8-14/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 120n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156281
PNG
(US9018217, 5,7-Dimethyl-2-(1-methyl-4-phenyl-1H-im...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3C)-c3ccccc3)nc2c1
Show InChI InChI=1S/C20H20N4S/c1-14-9-15(2)24-11-17(21-19(24)10-14)13-25-20-22-18(12-23(20)3)16-7-5-4-6-8-16/h4-12H,13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 140n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156355
PNG
(US9018217, 7-Methoxy-5-methyl-2-[2-(1-methyl-4-phe...)
Show SMILES COc1cc2nc(CCc3nc(cn3C)-c3ccccc3)nn2c(C)n1
Show InChI InChI=1S/C19H20N6O/c1-13-20-19(26-3)11-18-22-16(23-25(13)18)9-10-17-21-15(12-24(17)2)14-7-5-4-6-8-14/h4-8,11-12H,9-10H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 160n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156283
PNG
(US9018217, 7-Methyl-2-(1-methyl-4-phenyl-1H-imidaz...)
Show SMILES Cc1ccn2nc(SCc3nc(cn3C)-c3ccccc3)nc2c1
Show InChI InChI=1S/C18H17N5S/c1-13-8-9-23-16(10-13)20-18(21-23)24-12-17-19-15(11-22(17)2)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 170n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156282
PNG
(US9018217, 2-[4-(3-Methoxy-phenyl)-1-methyl-1H-imi...)
Show SMILES COc1cccc(c1)-c1cn(C)c(CSc2nc3cc(C)cc(C)n3n2)n1
Show InChI InChI=1S/C20H21N5OS/c1-13-8-14(2)25-18(9-13)22-20(23-25)27-12-19-21-17(11-24(19)3)15-6-5-7-16(10-15)26-4/h5-11H,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 170n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156285
PNG
(US9018217, 2-[4-(4-Fluoro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3ccc(F)cc3)nc2c1
Show InChI InChI=1S/C19H18FN5S/c1-12-8-13(2)25-17(9-12)22-19(23-25)26-11-18-21-16(10-24(18)3)14-4-6-15(20)7-5-14/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 180n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156284
PNG
(US9018217, 2-[4-(3-Chloro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3cccc(Cl)c3)nc2c1
Show InChI InChI=1S/C19H18ClN5S/c1-12-7-13(2)25-17(8-12)22-19(23-25)26-11-18-21-16(10-24(18)3)14-5-4-6-15(20)9-14/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 180n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156287
PNG
(US9018217, 2-[4-(3-Methoxy-phenyl)-1-methyl-1H-imi...)
Show SMILES COc1cccc(c1)-c1cn(C)c(SCc2cn3c(C)cc(C)nc3n2)n1
Show InChI InChI=1S/C20H21N5OS/c1-13-8-14(2)25-10-16(22-19(25)21-13)12-27-20-23-18(11-24(20)3)15-6-5-7-17(9-15)26-4/h5-11H,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 210n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156286
PNG
(US9018217, 2-[2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3CC(N)=O)-c3ccccc3)nc2c1
Show InChI InChI=1S/C20H20N6OS/c1-13-8-14(2)26-18(9-13)23-20(24-26)28-12-19-22-16(10-25(19)11-17(21)27)15-6-4-3-5-7-15/h3-10H,11-12H2,1-2H3,(H2,21,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 210n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156288
PNG
(US9018217, 5-Chloro-2-(1-methyl-4-phenyl-1H-imidaz...)
Show SMILES Cn1cc(nc1SCc1cn2c(Cl)cccc2n1)-c1ccccc1
Show InChI InChI=1S/C18H15ClN4S/c1-22-11-15(13-6-3-2-4-7-13)21-18(22)24-12-14-10-23-16(19)8-5-9-17(23)20-14/h2-11H,12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 220n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156289
PNG
(US9018217, 8-Methyl-2-(1-methyl-4-phenyl-1H-imidaz...)
Show SMILES Cc1cccn2cc(CSc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C19H18N4S/c1-14-7-6-10-23-11-16(20-18(14)23)13-24-19-21-17(12-22(19)2)15-8-4-3-5-9-15/h3-12H,13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 230n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156290
PNG
(US9018217, 2-[4-(2-Fluoro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3ccccc3F)nc2c1
Show InChI InChI=1S/C19H18FN5S/c1-12-8-13(2)25-17(9-12)22-19(23-25)26-11-18-21-16(10-24(18)3)14-6-4-5-7-15(14)20/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 240n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156292
PNG
(US9018217, 2-[2-(5,7-Dimethyl-imidazol[1,2-a]pyrim...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3CC(N)=O)-c3ccccc3)nc2n1
Show InChI InChI=1S/C20H20N6OS/c1-13-8-14(2)26-9-16(23-19(26)22-13)12-28-20-24-17(10-25(20)11-18(21)27)15-6-4-3-5-7-15/h3-10H,11-12H2,1-2H3,(H2,21,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 250n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156291
PNG
(US9018217, 2-[4-(2-Chloro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3ccccc3Cl)nc2c1
Show InChI InChI=1S/C19H18ClN5S/c1-12-8-13(2)25-17(9-12)22-19(23-25)26-11-18-21-16(10-24(18)3)14-6-4-5-7-15(14)20/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 250n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156293
PNG
(US9018217, 2-(1-Ethyl-4-phenyl-1H-imidazol-2-ylmet...)
Show SMILES CCn1cc(nc1CSc1nc2ccccn2n1)-c1ccccc1
Show InChI InChI=1S/C18H17N5S/c1-2-22-12-15(14-8-4-3-5-9-14)19-17(22)13-24-18-20-16-10-6-7-11-23(16)21-18/h3-12H,2,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 260n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156294
PNG
(US9018217, 2-[4-(2-Methoxy-phenyl)-1-methyl-1H-imi...)
Show SMILES COc1ccccc1-c1cn(C)c(CSc2nc3cc(C)cc(C)n3n2)n1
Show InChI InChI=1S/C20H21N5OS/c1-13-9-14(2)25-18(10-13)22-20(23-25)27-12-19-21-16(11-24(19)3)15-7-5-6-8-17(15)26-4/h5-11H,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 330n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM299379
PNG
(US9592230, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylme...)
Show SMILES Cn1cc(nc1CSc1nc2ccccc2n1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H20N4S/c1-27-16-21(18-10-4-2-5-11-18)25-23(27)17-29-24-26-20-14-8-9-15-22(20)28(24)19-12-6-3-7-13-19/h2-16H,17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156295
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cn1cc(nc1SCc1cn2ccc(cc2n1)C#N)-c1ccccc1
Show InChI InChI=1S/C19H15N5S/c1-23-12-17(15-5-3-2-4-6-15)22-19(23)25-13-16-11-24-8-7-14(10-20)9-18(24)21-16/h2-9,11-12H,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 360n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156318
PNG
(US9018217, 8-Methyl-2-(4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cc1cccn2cc(CSc3nc(c[nH]3)-c3ccccc3)nc12
Show InChI InChI=1S/C18H16N4S/c1-13-6-5-9-22-11-15(20-17(13)22)12-23-18-19-10-16(21-18)14-7-3-2-4-8-14/h2-11H,12H2,1H3,(H,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 370n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156296
PNG
(US9018217, 2-(1-Isopropyl-4-phenyl-1H-imidazol-2-y...)
Show SMILES CC(C)n1cc(nc1CSc1nc2ccccn2n1)-c1ccccc1
Show InChI InChI=1S/C19H19N5S/c1-14(2)23-12-16(15-8-4-3-5-9-15)20-18(23)13-25-19-21-17-10-6-7-11-24(17)22-19/h3-12,14H,13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 380n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156297
PNG
(US9018217, 2-[1-(4-Chloro-benzyl)-4-phenyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3Cc3ccc(Cl)cc3)-c3ccccc3)nc2c1
Show InChI InChI=1S/C25H22ClN5S/c1-17-12-18(2)31-23(13-17)28-25(29-31)32-16-24-27-22(20-6-4-3-5-7-20)15-30(24)14-19-8-10-21(26)11-9-19/h3-13,15H,14,16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 410n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156298
PNG
(US9018217, 6-Bromo-5,7-dimethyl-2-(1-methyl-4-phen...)
Show SMILES Cc1cc2nc(SCc3nc(cn3C)-c3ccccc3)nn2c(C)c1Br
Show InChI InChI=1S/C19H18BrN5S/c1-12-9-16-22-19(23-25(16)13(2)18(12)20)26-11-17-21-15(10-24(17)3)14-7-5-4-6-8-14/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 420n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156300
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cn1cc(nc1SCc1cc2ccccn2n1)-c1ccccc1
Show InChI InChI=1S/C18H16N4S/c1-21-12-17(14-7-3-2-4-8-14)19-18(21)23-13-15-11-16-9-5-6-10-22(16)20-15/h2-12H,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 430n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156299
PNG
(US9018217, 2-[4-(3-Fluoro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cn1cc(nc1CSc1nc2ccccn2n1)-c1cccc(F)c1
Show InChI InChI=1S/C17H14FN5S/c1-22-10-14(12-5-4-6-13(18)9-12)19-16(22)11-24-17-20-15-7-2-3-8-23(15)21-17/h2-10H,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 430n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156319
PNG
(US9018217, 2-[1-(4-Chloro-benzyl)-4-phenyl-1H-imid...)
Show SMILES Cc1cc(C)n2cc(CSc3nc(cn3Cc3ccc(Cl)cc3)-c3ccccc3)nc2n1
Show InChI InChI=1S/C25H22ClN5S/c1-17-12-18(2)31-14-22(28-24(31)27-17)16-32-25-29-23(20-6-4-3-5-7-20)15-30(25)13-19-8-10-21(26)11-9-19/h3-12,14-15H,13,16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 470n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156301
PNG
(US9018217, 5-Methyl-2-(1-methyl-4-phenyl-1H-imidaz...)
Show SMILES Cc1cccc2nc(CSc3nc(cn3C)-c3ccccc3)cn12
Show InChI InChI=1S/C19H18N4S/c1-14-7-6-10-18-20-16(11-23(14)18)13-24-19-21-17(12-22(19)2)15-8-4-3-5-9-15/h3-12H,13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 480n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156302
PNG
(US9018217, 2-[4-(4-Fluoro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cn1cc(nc1CSc1nc2ccccn2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H14FN5S/c1-22-10-14(12-5-7-13(18)8-6-12)19-16(22)11-24-17-20-15-4-2-3-9-23(15)21-17/h2-10H,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 570n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156303
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cn1cc(nc1SCc1nc2ccccc2n1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H20N4S/c1-27-16-21(18-10-4-2-5-11-18)26-24(27)29-17-23-25-20-14-8-9-15-22(20)28(23)19-12-6-3-7-13-19/h2-16H,17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 580n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156304
PNG
(US9018217, 2-[4-(3-Chloro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cn1cc(nc1CSc1nc2ccccn2n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H14ClN5S/c1-22-10-14(12-5-4-6-13(18)9-12)19-16(22)11-24-17-20-15-7-2-3-8-23(15)21-17/h2-10H,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 810n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156305
PNG
(US9018217, 2-(6-Chloro-imidazo[1,2-a]pyridin-2-ylm...)
Show SMILES Nn1cc(nc1SCc1cn2cc(Cl)ccc2n1)-c1ccccc1
Show InChI InChI=1S/C17H14ClN5S/c18-13-6-7-16-20-14(9-22(16)8-13)11-24-17-21-15(10-23(17)19)12-4-2-1-3-5-12/h1-10H,11,19H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 830n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156306
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylme...)
Show SMILES Cn1cc(nc1CSc1nc2ncccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H15N5S/c1-22-10-14(12-6-3-2-4-7-12)19-15(22)11-23-17-20-13-8-5-9-18-16(13)21-17/h2-10H,11H2,1H3,(H,18,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 840n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156307
PNG
(US9018217, 6-Chloro-8-methyl-2-(1-methyl-4-phenyl-...)
Show SMILES Cc1cc(Cl)cn2cc(CSc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C19H17ClN4S/c1-13-8-15(20)9-24-10-16(21-18(13)24)12-25-19-22-17(11-23(19)2)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 890n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156308
PNG
(US9018217, 2-[4-(4-Chloro-phenyl)-1-methyl-1H-imid...)
Show SMILES Cc1cc(C)n2nc(SCc3nc(cn3C)-c3ccc(Cl)cc3)nc2c1
Show InChI InChI=1S/C19H18ClN5S/c1-12-8-13(2)25-17(9-12)22-19(23-25)26-11-18-21-16(10-24(18)3)14-4-6-15(20)7-5-14/h4-10H,11H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156309
PNG
(US9018217, 6-Bromo-7-methyl-2-(1-methyl-4-phenyl-1...)
Show SMILES Cc1cc2nc(SCc3nc(cn3C)-c3ccccc3)nn2cc1Br
Show InChI InChI=1S/C18H16BrN5S/c1-12-8-16-21-18(22-24(16)9-14(12)19)25-11-17-20-15(10-23(17)2)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156311
PNG
(US9018217, 2-[2-(1-Amino-4-phenyl-1H-imidazol-2-yl...)
Show SMILES Nn1cc(nc1SCc1nc2ccc(Cl)cc2n1CCO)-c1ccccc1
Show InChI InChI=1S/C19H18ClN5OS/c20-14-6-7-15-17(10-14)24(8-9-26)18(22-15)12-27-19-23-16(11-25(19)21)13-4-2-1-3-5-13/h1-7,10-11,26H,8-9,12,21H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156312
PNG
(US9018217, 2-(Imidazo[1,2-a]pyridin-2-ylmethylsulf...)
Show SMILES Nn1cc(nc1SCc1cn2ccccc2n1)-c1ccccc1
Show InChI InChI=1S/C17H15N5S/c18-22-11-15(13-6-2-1-3-7-13)20-17(22)23-12-14-10-21-9-5-4-8-16(21)19-14/h1-11H,12,18H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156313
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cn1cc(nc1SCc1cn2ccccc2n1)-c1ccccc1
Show InChI InChI=1S/C18H16N4S/c1-21-12-16(14-7-3-2-4-8-14)20-18(21)23-13-15-11-22-10-6-5-9-17(22)19-15/h2-12H,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156310
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylme...)
Show SMILES Cn1cc(nc1CSc1nc2ncccn2n1)-c1ccccc1
Show InChI InChI=1S/C16H14N6S/c1-21-10-13(12-6-3-2-4-7-12)18-14(21)11-23-16-19-15-17-8-5-9-22(15)20-16/h2-10H,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156315
PNG
(US9018217, 2-[4-(4-Methoxy-phenyl)-1-methyl-1H-imi...)
Show SMILES COc1ccc(cc1)-c1cn(C)c(CSc2nc3cc(C)cc(C)n3n2)n1
Show InChI InChI=1S/C20H21N5OS/c1-13-9-14(2)25-18(10-13)22-20(23-25)27-12-19-21-17(11-24(19)3)15-5-7-16(26-4)8-6-15/h5-11H,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156314
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylme...)
Show SMILES Cn1cc(nc1CSc1nc2ccc(cn2n1)C#N)-c1ccccc1
Show InChI InChI=1S/C18H14N6S/c1-23-11-15(14-5-3-2-4-6-14)20-17(23)12-25-18-21-16-8-7-13(9-19)10-24(16)22-18/h2-8,10-11H,12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156316
PNG
(US9018217, 1-Methyl-2-(1-methyl-4-phenyl-1H-imidaz...)
Show SMILES Cn1cc(nc1CSc1nc2ccccc2n1C)-c1ccccc1
Show InChI InChI=1S/C19H18N4S/c1-22-12-16(14-8-4-3-5-9-14)20-18(22)13-24-19-21-15-10-6-7-11-17(15)23(19)2/h3-12H,13H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.80E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156317
PNG
(US9018217, 2-(1-Methyl-4-phenyl-1H-imidazol-2-ylsu...)
Show SMILES Cn1cc(nc1SCc1cn2cccnc2n1)-c1ccccc1
Show InChI InChI=1S/C17H15N5S/c1-21-11-15(13-6-3-2-4-7-13)20-17(21)23-12-14-10-22-9-5-8-18-16(22)19-14/h2-11H,12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.90E+3n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%