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Patent code US9593110

Compile Data Set for Download or QSAR

Found 201 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM300255
PNG
(US9593110, 18-2)
Show SMILES CCCc1nc(co1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H24Cl2FN3O4/c1-2-3-22-30-21(12-34-22)23(31)29-16(11-20(28)24(32)33)8-14-5-4-13(9-18(14)26)17-10-15(25)6-7-19(17)27/h4-7,9-10,12,16,20H,2-3,8,11,28H2,1H3,(H,29,31)(H,32,33)/t16-,20-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300266
PNG
(US9593110, 2-8)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cocn1)C(O)=O
Show InChI InChI=1S/C23H22ClFN2O5/c1-31-11-16(23(29)30)9-18(27-22(28)21-12-32-13-26-21)8-14-2-4-15(5-3-14)19-10-17(24)6-7-20(19)25/h2-7,10,12-13,16,18H,8-9,11H2,1H3,(H,27,28)(H,29,30)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300271
PNG
(US9593110, 18-8)
Show SMILES COCc1cc(no1)C(=O)N[C@@H](C[C@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C23H22Cl2FN3O5/c1-33-11-16-10-21(29-34-16)22(30)28-15(9-20(27)23(31)32)6-13-3-2-12(7-18(13)25)17-8-14(24)4-5-19(17)26/h2-5,7-8,10,15,20H,6,9,11,27H2,1H3,(H,28,30)(H,31,32)/t15-,20+/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300281
PNG
(US9593110, 2-15)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O5/c1-14-12-27-23(33-14)22(29)28-19(10-17(13-32-2)24(30)31)9-15-3-5-16(6-4-15)20-11-18(25)7-8-21(20)26/h3-8,11-12,17,19H,9-10,13H2,1-2H3,(H,28,29)(H,30,31)/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300283
PNG
(US9593110, 21-1)
Show SMILES CCc1cc(on1)C(=O)N[C@@H](C[C@@H](CN)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H25ClFN3O4/c1-2-18-12-22(33-29-18)23(30)28-19(10-16(13-27)24(31)32)9-14-3-5-15(6-4-14)20-11-17(25)7-8-21(20)26/h3-8,11-12,16,19H,2,9-10,13,27H2,1H3,(H,28,30)(H,31,32)/t16-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300322
PNG
(US9593110, 30-11)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1coc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C23H21ClFN3O7/c1-34-22(32)27-18(21(30)31)10-15(26-20(29)19-11-35-23(33)28-19)8-12-2-4-13(5-3-12)16-9-14(24)6-7-17(16)25/h2-7,9,11,15,18H,8,10H2,1H3,(H,26,29)(H,27,32)(H,28,33)(H,30,31)/t15-,18-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300339
PNG
(US9593110, 41)
Show SMILES NCCC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C23H24ClFN6O4/c24-15-5-6-18(25)17(10-15)14-3-1-13(2-4-14)9-16(28-22(33)20-12-27-31-30-20)11-19(23(34)35)29-21(32)7-8-26/h1-6,10,12,16,19H,7-9,11,26H2,(H,28,33)(H,29,32)(H,34,35)(H,27,30,31)/t16-,19-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300355
PNG
(US9593110, 52-1)
Show SMILES Cc1cc(sn1)C(=O)N[C@@H](C[C@@H](CC#N)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H21ClFN3O3S/c1-14-10-22(33-29-14)23(30)28-19(12-17(8-9-27)24(31)32)11-15-2-4-16(5-3-15)20-13-18(25)6-7-21(20)26/h2-7,10,13,17,19H,8,11-12H2,1H3,(H,28,30)(H,31,32)/t17-,19-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299466
PNG
((2R,4R)-5-(5′-Chloro-2′-fluorobiphenyl...)
Show SMILES CNCCCC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C25H28ClFN6O4/c1-28-10-2-3-23(34)31-21(25(36)37)13-18(30-24(35)22-14-29-33-32-22)11-15-4-6-16(7-5-15)19-12-17(26)8-9-20(19)27/h4-9,12,14,18,21,28H,2-3,10-11,13H2,1H3,(H,30,35)(H,31,34)(H,36,37)(H,29,32,33)/t18-,21-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299493
PNG
((2S,4S)-5-Biphenyl-4-yl-2-methoxymethyl-4-[(1H-[1,...)
Show SMILES CCOC(=O)[C@H](COC)C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1c[nH]nn1
Show InChI InChI=1S/C24H28N4O4/c1-3-32-24(30)20(16-31-2)14-21(26-23(29)22-15-25-28-27-22)13-17-9-11-19(12-10-17)18-7-5-4-6-8-18/h4-12,15,20-21H,3,13-14,16H2,1-2H3,(H,26,29)(H,25,27,28)/t20-,21+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299630
PNG
((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C28H32BClFNO6S/c1-4-37-28(33)22(18-38-39(35,36)25-12-5-19(2)6-13-25)16-24(32-29(3)34)15-20-7-9-21(10-8-20)26-17-23(30)11-14-27(26)31/h5-14,17,22,24,32,34H,4,15-16,18H2,1-3H3/t22-,24+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299630
PNG
((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(C)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C28H32BClFNO6S/c1-4-37-28(33)22(18-38-39(35,36)25-12-5-19(2)6-13-25)16-24(32-29(3)34)15-20-7-9-21(10-8-20)26-17-23(30)11-14-27(26)31/h5-14,17,22,24,32,34H,4,15-16,18H2,1-3H3/t22-,24+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299666
PNG
(US9593110, Example 97a | US9593110, Example 98a)
Show SMILES CCOC(=O)[C@@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O)OS(C)(=O)=O
Show InChI InChI=1S/C21H26BClFNO6S/c1-4-30-21(26)20(31-32(3,28)29)13-17(25-22(2)27)11-14-5-7-15(8-6-14)18-12-16(23)9-10-19(18)24/h5-10,12,17,20,25,27H,4,11,13H2,1-3H3/t17-,20-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299642
PNG
(US9593110, Example 101b | US9593110, Example 101c ...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(Br)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C27H29BBrClFNO6S/c1-3-37-27(33)20(17-38-39(35,36)24-11-8-21(29)9-12-24)15-23(32-28(2)34)14-18-4-6-19(7-5-18)25-16-22(30)10-13-26(25)31/h4-13,16,20,23,32,34H,3,14-15,17H2,1-2H3/t20-,23+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300257
PNG
(US9593110, 2-5)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C23H22ClFN2O6/c1-32-12-15(23(30)31)9-17(26-22(29)20-11-21(28)27-33-20)8-13-2-4-14(5-3-13)18-10-16(24)6-7-19(18)25/h2-7,10-11,15,17H,8-9,12H2,1H3,(H,26,29)(H,27,28)(H,30,31)/t15-,17+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300258
PNG
(US9593110, 18-3)
Show SMILES Cc1cnc(o1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H20Cl2FN3O4/c1-11-10-27-21(32-11)20(29)28-15(9-19(26)22(30)31)6-13-3-2-12(7-17(13)24)16-8-14(23)4-5-18(16)25/h2-5,7-8,10,15,19H,6,9,26H2,1H3,(H,28,29)(H,30,31)/t15-,19-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300296
PNG
(US9593110, 7-4)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O6/c1-2-33-13-16(24(31)32)10-18(27-23(30)21-12-22(29)28-34-21)9-14-3-5-15(6-4-14)19-11-17(25)7-8-20(19)26/h3-8,11-12,16,18H,2,9-10,13H2,1H3,(H,27,30)(H,28,29)(H,31,32)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300298
PNG
(US9593110, 7-6)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncco1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O5/c1-2-32-14-17(24(30)31)12-19(28-22(29)23-27-9-10-33-23)11-15-3-5-16(6-4-15)20-13-18(25)7-8-21(20)26/h3-10,13,17,19H,2,11-12,14H2,1H3,(H,28,29)(H,30,31)/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300318
PNG
(US9593110, 30-7)
Show SMILES CCOc1nc(co1)C(=O)N[C@@H](C[C@@H](NC(=O)OC)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C25H25ClFN3O7/c1-3-36-25-30-21(13-37-25)22(31)28-17(12-20(23(32)33)29-24(34)35-2)10-14-4-6-15(7-5-14)18-11-16(26)8-9-19(18)27/h4-9,11,13,17,20H,3,10,12H2,1-2H3,(H,28,31)(H,29,34)(H,32,33)/t17-,20-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300349
PNG
(US9593110, 16-25)
Show SMILES N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1nc2cc(Cl)ccn2n1)C(O)=O
Show InChI InChI=1S/C24H20Cl2FN5O3/c25-15-5-6-19(27)18(10-15)14-3-1-13(2-4-14)9-17(12-20(28)24(34)35)29-23(33)22-30-21-11-16(26)7-8-32(21)31-22/h1-8,10-11,17,20H,9,12,28H2,(H,29,33)(H,34,35)/t17-,20-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299347
PNG
((2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl...)
Show SMILES CCOC(=O)[C@H](COC)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(CC)no1
Show InChI InChI=1S/C27H30ClFN2O5/c1-4-21-15-25(36-31-21)26(32)30-22(13-19(16-34-3)27(33)35-5-2)12-17-6-8-18(9-7-17)23-14-20(28)10-11-24(23)29/h6-11,14-15,19,22H,4-5,12-13,16H2,1-3H3,(H,30,32)/t19-,22+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299643
PNG
((2R,4R)-2-Amino-5-(5′-chloro-2′-fluoro...)
Show SMILES OC(=O)[C@@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)N=[N+]=[N-]
Show InChI InChI=1S/C20H17ClFN7O3/c21-13-5-6-16(22)15(8-13)12-3-1-11(2-4-12)7-14(9-17(20(31)32)26-28-23)25-19(30)18-10-24-29-27-18/h1-6,8,10,14,17H,7,9H2,(H,25,30)(H,31,32)(H,24,27,29)/t14-,17-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299642
PNG
(US9593110, Example 101b | US9593110, Example 101c ...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(Br)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C27H29BBrClFNO6S/c1-3-37-27(33)20(17-38-39(35,36)24-11-8-21(29)9-12-24)15-23(32-28(2)34)14-18-4-6-19(7-5-18)25-16-22(30)10-13-26(25)31/h4-13,16,20,23,32,34H,3,14-15,17H2,1-2H3/t20-,23+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299642
PNG
(US9593110, Example 101b | US9593110, Example 101c ...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(Br)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C27H29BBrClFNO6S/c1-3-37-27(33)20(17-38-39(35,36)24-11-8-21(29)9-12-24)15-23(32-28(2)34)14-18-4-6-19(7-5-18)25-16-22(30)10-13-26(25)31/h4-13,16,20,23,32,34H,3,14-15,17H2,1-2H3/t20-,23+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300278
PNG
(US9593110, 18-11)
Show SMILES COc1cnc(o1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H20Cl2FN3O5/c1-32-19-10-27-21(33-19)20(29)28-14(9-18(26)22(30)31)6-12-3-2-11(7-16(12)24)15-8-13(23)4-5-17(15)25/h2-5,7-8,10,14,18H,6,9,26H2,1H3,(H,28,29)(H,30,31)/t14-,18-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300297
PNG
(US9593110, 7-5)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(CC)no1)C(O)=O
Show InChI InChI=1S/C26H28ClFN2O5/c1-3-20-14-24(35-30-20)25(31)29-21(12-18(26(32)33)15-34-4-2)11-16-5-7-17(8-6-16)22-13-19(27)9-10-23(22)28/h5-10,13-14,18,21H,3-4,11-12,15H2,1-2H3,(H,29,31)(H,32,33)/t18-,21+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300308
PNG
(US9593110, 9-2)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc([nH]n1)C(C)=O)C(O)=O
Show InChI InChI=1S/C26H28ClN3O5/c1-3-35-15-20(26(33)34)13-22(28-25(32)24-14-23(16(2)31)29-30-24)11-17-7-9-18(10-8-17)19-5-4-6-21(27)12-19/h4-10,12,14,20,22H,3,11,13,15H2,1-2H3,(H,28,32)(H,29,30)(H,33,34)/t20-,22+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300310
PNG
(US9593110, 9-3)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1n[nH]c(n1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C24H24ClF3N4O4/c1-2-36-13-17(22(34)35)12-19(29-21(33)20-30-23(32-31-20)24(26,27)28)10-14-6-8-15(9-7-14)16-4-3-5-18(25)11-16/h3-9,11,17,19H,2,10,12-13H2,1H3,(H,29,33)(H,34,35)(H,30,31,32)/t17-,19+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300315
PNG
(US9593110, 30-4)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O
Show InChI InChI=1S/C24H23ClFN3O6/c1-13-12-27-22(35-13)21(30)28-17(11-20(23(31)32)29-24(33)34-2)9-14-3-5-15(6-4-14)18-10-16(25)7-8-19(18)26/h3-8,10,12,17,20H,9,11H2,1-2H3,(H,28,30)(H,29,33)(H,31,32)/t17-,20-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300338
PNG
(US9593110, 39-1)
Show SMILES CC(C)[C@H](N)C(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C25H28ClFN6O4/c1-13(2)22(28)24(35)31-20(25(36)37)11-17(30-23(34)21-12-29-33-32-21)9-14-3-5-15(6-4-14)18-10-16(26)7-8-19(18)27/h3-8,10,12-13,17,20,22H,9,11,28H2,1-2H3,(H,30,34)(H,31,35)(H,36,37)(H,29,32,33)/t17-,20-,22+/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300342
PNG
(US9593110, 16-18)
Show SMILES CN(C)C(=O)c1cc([nH]n1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H25ClFN5O4/c1-31(2)23(33)21-12-20(29-30-21)22(32)28-16(11-19(27)24(34)35)9-13-3-5-14(6-4-13)17-10-15(25)7-8-18(17)26/h3-8,10,12,16,19H,9,11,27H2,1-2H3,(H,28,32)(H,29,30)(H,34,35)/t16-,19-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300347
PNG
(US9593110, 16-23)
Show SMILES Cc1ccccc1-c1n[nH]c(C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc2ccc(cc2)-c2cc(Cl)ccc2F)c1F
Show InChI InChI=1S/C28H25ClF2N4O3/c1-15-4-2-3-5-20(15)25-24(31)26(35-34-25)27(36)33-19(14-23(32)28(37)38)12-16-6-8-17(9-7-16)21-13-18(29)10-11-22(21)30/h2-11,13,19,23H,12,14,32H2,1H3,(H,33,36)(H,34,35)(H,37,38)/t19-,23-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299348
PNG
((2S,4S)-5-Biphenyl-4-yl-2-carbamoylmethyl-4-[(3H-[...)
Show SMILES NC(=O)C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C22H23N5O4/c23-20(28)12-17(22(30)31)11-18(25-21(29)19-13-24-27-26-19)10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,13,17-18H,10-12H2,(H2,23,28)(H,25,29)(H,30,31)(H,24,26,27)/t17-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299355
PNG
(US9593110, Example 48a | US9593110, Example 48b | ...)
Show SMILES CCOC(=O)[C@H](COS(C)(=O)=O)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C22H28BClFNO6S/c1-4-31-22(27)17(14-32-33(3,29)30)12-19(26-23(2)28)11-15-5-7-16(8-6-15)20-13-18(24)9-10-21(20)25/h5-10,13,17,19,26,28H,4,11-12,14H2,1-3H3/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299495
PNG
((2R,4R)-2-(5-Amino-pentanoylamino)-5-(5′-chl...)
Show SMILES NCCCCC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C25H28ClFN6O4/c26-17-8-9-20(27)19(12-17)16-6-4-15(5-7-16)11-18(30-24(35)22-14-29-33-32-22)13-21(25(36)37)31-23(34)3-1-2-10-28/h4-9,12,14,18,21H,1-3,10-11,13,28H2,(H,30,35)(H,31,34)(H,36,37)(H,29,32,33)/t18-,21-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299498
PNG
((2R,4R)-5-(5′-Chloro-2′-fluorobiphenyl...)
Show SMILES CN(C)CCCC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C26H30ClFN6O4/c1-34(2)11-3-4-24(35)31-22(26(37)38)14-19(30-25(36)23-15-29-33-32-23)12-16-5-7-17(8-6-16)20-13-18(27)9-10-21(20)28/h5-10,13,15,19,22H,3-4,11-12,14H2,1-2H3,(H,30,36)(H,31,35)(H,37,38)(H,29,32,33)/t19-,22-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299639
PNG
((2S,4S)-5-Biphenyl-4-yl-2-ethoxymethyl-4-[(1H-[1,2...)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1c[nH]nn1)C(=O)OCC
Show InChI InChI=1S/C25H30N4O4/c1-3-32-17-21(25(31)33-4-2)15-22(27-24(30)23-16-26-29-28-23)14-18-10-12-20(13-11-18)19-8-6-5-7-9-19/h5-13,16,21-22H,3-4,14-15,17H2,1-2H3,(H,27,30)(H,26,28,29)/t21-,22+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299647
PNG
((2R,4R)-2-Amino-5-(5′-chloro-2′-fluoro...)
Show SMILES CC(C)c1coc(n1)C(=O)N[C@@H](C[C@@H](N=[N+]=[N-])C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H23ClFN5O4/c1-13(2)21-12-35-23(29-21)22(32)28-17(11-20(24(33)34)30-31-27)9-14-3-5-15(6-4-14)18-10-16(25)7-8-19(18)26/h3-8,10,12-13,17,20H,9,11H2,1-2H3,(H,28,32)(H,33,34)/t17-,20-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299642
PNG
(US9593110, Example 101b | US9593110, Example 101c ...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(Br)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C27H29BBrClFNO6S/c1-3-37-27(33)20(17-38-39(35,36)24-11-8-21(29)9-12-24)15-23(32-28(2)34)14-18-4-6-19(7-5-18)25-16-22(30)10-13-26(25)31/h4-13,16,20,23,32,34H,3,14-15,17H2,1-2H3/t20-,23+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299670
PNG
(US9593110, Example 45)
Show SMILES CB(O)NC(C)(C)C(=O)NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O
Show InChI InChI=1S/C28H33BClFN4O6/c1-16-14-32-25(41-16)24(36)34-21(12-19(26(37)38)15-33-27(39)28(2,3)35-29(4)40)11-17-5-7-18(8-6-17)22-13-20(30)9-10-23(22)31/h5-10,13-14,19,21,35,40H,11-12,15H2,1-4H3,(H,33,39)(H,34,36)(H,37,38)/t19-,21+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299642
PNG
(US9593110, Example 101b | US9593110, Example 101c ...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(Br)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C27H29BBrClFNO6S/c1-3-37-27(33)20(17-38-39(35,36)24-11-8-21(29)9-12-24)15-23(32-28(2)34)14-18-4-6-19(7-5-18)25-16-22(30)10-13-26(25)31/h4-13,16,20,23,32,34H,3,14-15,17H2,1-2H3/t20-,23+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299355
PNG
(US9593110, Example 48a | US9593110, Example 48b | ...)
Show SMILES CCOC(=O)[C@H](COS(C)(=O)=O)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C22H28BClFNO6S/c1-4-31-22(27)17(14-32-33(3,29)30)12-19(26-23(2)28)11-15-5-7-16(8-6-15)20-13-18(24)9-10-21(20)25/h5-10,13,17,19,26,28H,4,11-12,14H2,1-3H3/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299642
PNG
(US9593110, Example 101b | US9593110, Example 101c ...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(Br)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C27H29BBrClFNO6S/c1-3-37-27(33)20(17-38-39(35,36)24-11-8-21(29)9-12-24)15-23(32-28(2)34)14-18-4-6-19(7-5-18)25-16-22(30)10-13-26(25)31/h4-13,16,20,23,32,34H,3,14-15,17H2,1-2H3/t20-,23+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM299642
PNG
(US9593110, Example 101b | US9593110, Example 101c ...)
Show SMILES CCOC(=O)[C@H](COS(=O)(=O)c1ccc(Br)cc1)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NB(C)O
Show InChI InChI=1S/C27H29BBrClFNO6S/c1-3-37-27(33)20(17-38-39(35,36)24-11-8-21(29)9-12-24)15-23(32-28(2)34)14-18-4-6-19(7-5-18)25-16-22(30)10-13-26(25)31/h4-13,16,20,23,32,34H,3,14-15,17H2,1-2H3/t20-,23+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300273
PNG
(US9593110, 2-11)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1noc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C22H21ClFN3O6/c1-32-11-14(21(29)30)9-16(25-20(28)19-26-22(31)33-27-19)8-12-2-4-13(5-3-12)17-10-15(23)6-7-18(17)24/h2-7,10,14,16H,8-9,11H2,1H3,(H,25,28)(H,29,30)(H,26,27,31)/t14-,16+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300276
PNG
(US9593110, 18-10)
Show SMILES N[C@@H](C[C@@H](Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F)NC(=O)c1cc(on1)C1CC1)C(O)=O
Show InChI InChI=1S/C24H22Cl2FN3O4/c25-15-5-6-19(27)17(9-15)13-3-4-14(18(26)8-13)7-16(10-20(28)24(32)33)29-23(31)21-11-22(34-30-21)12-1-2-12/h3-6,8-9,11-12,16,20H,1-2,7,10,28H2,(H,29,31)(H,32,33)/t16-,20+/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300287
PNG
(US9593110, 21-3)
Show SMILES Cc1cnc(o1)C(=O)N[C@@H](C[C@@H](CN)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C23H23ClFN3O4/c1-13-12-27-22(32-13)21(29)28-18(9-16(11-26)23(30)31)8-14-2-4-15(5-3-14)19-10-17(24)6-7-20(19)25/h2-7,10,12,16,18H,8-9,11,26H2,1H3,(H,28,29)(H,30,31)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300292
PNG
(US9593110, 7-1)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C23H24ClFN4O4/c1-2-33-13-16(23(31)32)10-18(27-22(30)21-12-26-29-28-21)9-14-3-5-15(6-4-14)19-11-17(24)7-8-20(19)25/h3-8,11-12,16,18H,2,9-10,13H2,1H3,(H,27,30)(H,31,32)(H,26,28,29)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300312
PNG
(US9593110, 9-4)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(OC)no1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O6/c1-3-33-15-19(25(30)31)13-21(27-24(29)22-14-23(32-2)28-34-22)11-16-7-9-17(10-8-16)18-5-4-6-20(26)12-18/h4-10,12,14,19,21H,3,11,13,15H2,1-2H3,(H,27,29)(H,30,31)/t19-,21+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300343
PNG
(US9593110, 44-1)
Show SMILES NCC(=O)NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C23H24ClFN6O4/c24-16-5-6-19(25)18(9-16)14-3-1-13(2-4-14)7-17(29-22(33)20-12-28-31-30-20)8-15(23(34)35)11-27-21(32)10-26/h1-6,9,12,15,17H,7-8,10-11,26H2,(H,27,32)(H,29,33)(H,34,35)(H,28,30,31)/t15-,17+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%