BindingDB logo
myBDB logout

Patent code US9593121

Compile Data Set for Download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299243
PNG
(US9593121, I-06 | {(1S,2S,4R)-2-hydroxy-4-[4-(6-me...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccc(C)cc2[nH]1
Show InChI InChI=1S/C21H21N4O/c1-12-3-4-14-9-18(24-17(14)7-12)20-16-5-6-25(21(16)23-11-22-20)15-8-13(2)19(26)10-15/h3-7,9,11,13,15,19,24,26H,2,8,10H2,1H3/t13-,15+,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299257
PNG
(US9593121, I-07 | {(1S,2S,4R)-2-hydroxy-4-[4-(6-me...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccc(OC)cc2[nH]1
Show InChI InChI=1S/C21H21N4O2/c1-12-7-14(9-19(12)26)25-6-5-16-20(22-11-23-21(16)25)18-8-13-3-4-15(27-2)10-17(13)24-18/h3-6,8,10-12,14,19,24,26H,1,7,9H2,2H3/t12-,14+,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299241
PNG
(US9593121, I-04 | {(1S,2S,4R)-4-[4-(6-chloro-1H-in...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C20H18ClN4O/c1-11-6-14(9-18(11)26)25-5-4-15-19(22-10-23-20(15)25)17-7-12-2-3-13(21)8-16(12)24-17/h2-5,7-8,10-11,14,18,24,26H,1,6,9H2/t11-,14+,18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299240
PNG
(US9593121, I-03 | {(1S,2S,4R)-2-hydroxy-4-[4-(5-me...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C21H21N4O2/c1-12-7-14(10-19(12)26)25-6-5-16-20(22-11-23-21(16)25)18-9-13-8-15(27-2)3-4-17(13)24-18/h3-6,8-9,11-12,14,19,24,26H,1,7,10H2,2H3/t12-,14+,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299236
PNG
(((1S,2S,4R)-4-(4-(1H-indol-2-yl)-7H-pyrrolo[2,3- d...)
Show SMILES NS(=O)(=O)OC[C@@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C20H21N5O4S/c21-30(27,28)29-10-13-7-14(9-18(13)26)25-6-5-15-19(22-11-23-20(15)25)17-8-12-3-1-2-4-16(12)24-17/h1-6,8,11,13-14,18,24,26H,7,9-10H2,(H2,21,27,28)/t13-,14+,18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299242
PNG
(US9593121, I-05 | {(1S,2S,4R)-4-[4-(6-cyano-1H-ind...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C21H18N5O/c1-12-6-15(9-19(12)27)26-5-4-16-20(23-11-24-21(16)26)18-8-14-3-2-13(10-22)7-17(14)25-18/h2-5,7-8,11-12,15,19,25,27H,1,6,9H2/t12-,15+,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299259
PNG
(US9593121, I-08 | {(1S,2S,4R)-2-hydroxy-4-[4-(1H-i...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(nc(C)nc12)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H21N4O/c1-12-9-15(11-19(12)26)25-8-7-16-20(22-13(2)23-21(16)25)18-10-14-5-3-4-6-17(14)24-18/h3-8,10,12,15,19,24,26H,1,9,11H2,2H3/t12-,15+,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299276
PNG
(US9593121, I-11 | {(1S,2S,4R)-4-[4-(5-fluoro-1H-in...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C20H18FN4O/c1-11-6-14(9-18(11)26)25-5-4-15-19(22-10-23-20(15)25)17-8-12-7-13(21)2-3-16(12)24-17/h2-5,7-8,10-11,14,18,24,26H,1,6,9H2/t11-,14+,18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299322
PNG
(US9593121, I-14 | [(1S,2S,4R)-2-hydroxy-4-{4-[6-(t...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N4O/c1-11-6-14(9-18(11)29)28-5-4-15-19(25-10-26-20(15)28)17-7-12-2-3-13(21(22,23)24)8-16(12)27-17/h2-5,7-8,10-11,14,18,27,29H,1,6,9H2/t11-,14+,18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299282
PNG
(US9593121, I-12 | {(1S,2S,4R)-2-hydroxy-4-[4-(7-me...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2cccc(OC)c2[nH]1
Show InChI InChI=1S/C21H21N4O2/c1-12-8-14(10-17(12)26)25-7-6-15-20(22-11-23-21(15)25)16-9-13-4-3-5-18(27-2)19(13)24-16/h3-7,9,11-12,14,17,24,26H,1,8,10H2,2H3/t12-,14+,17-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299265
PNG
(US9593121, I-10 | tert-butyl 2-(7-{(1R,3S,4S)-3-hy...)
Show SMILES COc1ccc2cc(-c3ncnc4n(ccc34)[C@H]3C[C@H](O)[C@H](COS(N)(=O)=O)C3)n(C(=O)OC(C)(C)C)c2c1
Show InChI InChI=1S/C26H31N5O7S/c1-26(2,3)38-25(33)31-20-12-18(36-4)6-5-15(20)10-21(31)23-19-7-8-30(24(19)29-14-28-23)17-9-16(22(32)11-17)13-37-39(27,34)35/h5-8,10,12,14,16-17,22,32H,9,11,13H2,1-4H3,(H2,27,34,35)/t16-,17+,22-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299237
PNG
(US9593121, I-02 | {(1S,2S,4R)-2-hydroxy-4-[4-(1-me...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2ccccc2n1C
Show InChI InChI=1S/C21H21N4O/c1-13-9-15(11-19(13)26)25-8-7-16-20(22-12-23-21(16)25)18-10-14-5-3-4-6-17(14)24(18)2/h3-8,10,12-13,15,19,26H,1,9,11H2,2H3/t13-,15+,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299263
PNG
(US9593121, I-09 | {(1S,2S,4R)-4-[4-(6-chloro-5-flu...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1cc2cc(F)c(Cl)cc2[nH]1
Show InChI InChI=1S/C20H17ClFN4O/c1-10-4-12(7-18(10)27)26-3-2-13-19(23-9-24-20(13)26)17-6-11-5-15(22)14(21)8-16(11)25-17/h2-3,5-6,8-10,12,18,25,27H,1,4,7H2/t10-,12+,18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6


(Homo sapiens)
BDBM299284
PNG
(US9593121, I-13 | {(1S,2S,4R)-2-hydroxy-4-[4-(3-me...)
Show SMILES [CH2][C@H]1C[C@H](C[C@@H]1O)n1ccc2c(ncnc12)-c1[nH]c2ccccc2c1C
Show InChI InChI=1S/C21H21N4O/c1-12-9-14(10-18(12)26)25-8-7-16-20(22-11-23-21(16)25)19-13(2)15-5-3-4-6-17(15)24-19/h3-8,11-12,14,18,24,26H,1,9-10H2,2H3/t12-,14+,18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...


US Patent US9593121 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%