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Patent code US9597326

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301784
PNG
(US9597326, Compound 3)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCP(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C23H24N3O4P/c1-14-3-8-19-20-11-16(12-25-22(20)23(24)26-21(19)9-14)4-5-17-6-7-18(10-15(17)2)30-13-31(27,28)29/h3,6-12H,4-5,13H2,1-2H3,(H2,24,26)(H2,27,28,29)
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n/an/an/an/a 3.17E+3n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189281
PNG
(CHEMBL3827669 | US9597326, Compound 16)
Show SMILES Cc1cc(OCCCC(F)(F)P(O)(O)=O)ccc1CCc1cnc2c(N)nc3cc(CCC(O)=O)ccc3c2c1
Show InChI InChI=1S/C28H30F2N3O6P/c1-17-13-21(39-12-2-11-28(29,30)40(36,37)38)8-7-20(17)6-3-19-14-23-22-9-4-18(5-10-25(34)35)15-24(22)33-27(31)26(23)32-16-19/h4,7-9,13-16H,2-3,5-6,10-12H2,1H3,(H2,31,33)(H,34,35)(H2,36,37,38)
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n/an/an/an/a 137n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301789
PNG
(US9597326, Compound 8)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCc4ccc(CC(F)(F)P(O)(O)=O)cc4)cc3C)cc21
Show InChI InChI=1S/C31H30F2N3O4P/c1-19-3-12-26-27-15-23(17-35-29(27)30(34)36-28(26)13-19)8-9-24-10-11-25(14-20(24)2)40-18-22-6-4-21(5-7-22)16-31(32,33)41(37,38)39/h3-7,10-15,17H,8-9,16,18H2,1-2H3,(H2,34,36)(H2,37,38,39)
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n/an/an/an/a 375n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189290
PNG
(CHEMBL3828149 | US9597326, Compound 9)
Show SMILES COc1ccc(CCc2cnc3c(N)nc4cc(ccc4c3c2)C(=O)C(F)(F)P(O)(O)=O)c(C)c1
Show InChI InChI=1S/C24H22F2N3O5P/c1-13-9-17(34-2)7-5-15(13)4-3-14-10-19-18-8-6-16(22(30)24(25,26)35(31,32)33)11-20(18)29-23(27)21(19)28-12-14/h5-12H,3-4H2,1-2H3,(H2,27,29)(H2,31,32,33)
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n/an/an/an/a 390n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189291
PNG
(CHEMBL3827959 | US9597326, Compound 14)
Show SMILES COc1ccc(CCc2cnc3c(N)nc4cc(ccc4c3c2)C(=O)P(O)(O)=O)c(C)c1
Show InChI InChI=1S/C23H22N3O5P/c1-13-9-17(31-2)7-5-15(13)4-3-14-10-19-18-8-6-16(23(27)32(28,29)30)11-20(18)26-22(24)21(19)25-12-14/h5-12H,3-4H2,1-2H3,(H2,24,26)(H2,28,29,30)
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n/an/an/an/a 885n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189180
PNG
(CHEMBL3827257 | US9597326, Compound 18)
Show SMILES Cc1cc(OCCOCCOCCC(F)(F)P(O)(O)=O)ccc1CCc1cnc2c(N)nc3cc(CCC(O)=O)ccc3c2c1
Show InChI InChI=1S/C31H36F2N3O8P/c1-20-16-24(44-15-14-43-13-12-42-11-10-31(32,33)45(39,40)41)7-6-23(20)5-2-22-17-26-25-8-3-21(4-9-28(37)38)18-27(25)36-30(34)29(26)35-19-22/h3,6-8,16-19H,2,4-5,9-15H2,1H3,(H2,34,36)(H,37,38)(H2,39,40,41)
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n/an/an/an/a 5n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301810
PNG
(US9597326, Compound 26)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCc4ccc(CP(O)(O)=O)cc4)cc3C)cc21
Show InChI InChI=1S/C30H30N3O4P/c1-19-3-12-26-27-15-23(16-32-29(27)30(31)33-28(26)13-19)8-9-24-10-11-25(14-20(24)2)37-17-21-4-6-22(7-5-21)18-38(34,35)36/h3-7,10-16H,8-9,17-18H2,1-2H3,(H2,31,33)(H2,34,35,36)
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n/an/an/an/a 975n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301798
PNG
(US9597326, Compound 13)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCc4cccc(c4)P(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C29H28N3O4P/c1-18-6-11-25-26-15-20(16-31-28(26)29(30)32-27(25)12-18)7-8-22-9-10-23(13-19(22)2)36-17-21-4-3-5-24(14-21)37(33,34)35/h3-6,9-16H,7-8,17H2,1-2H3,(H2,30,32)(H2,33,34,35)
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n/an/an/an/a 1.05E+3n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189282
PNG
(CHEMBL3828331 | US9597326, Compound 15)
Show SMILES Cc1cc(OCCCP(O)(O)=O)ccc1CCc1cnc2c(N)nc3cc(CCC(O)=O)ccc3c2c1
Show InChI InChI=1S/C27H30N3O6P/c1-17-13-21(36-11-2-12-37(33,34)35)8-7-20(17)6-3-19-14-23-22-9-4-18(5-10-25(31)32)15-24(22)30-27(28)26(23)29-16-19/h4,7-9,13-16H,2-3,5-6,10-12H2,1H3,(H2,28,30)(H,31,32)(H2,33,34,35)
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n/an/an/an/a 65n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301783
PNG
(US9597326, Compound 2)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OP(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C22H22N3O4P/c1-13-3-8-18-19-11-15(12-24-21(19)22(23)25-20(18)9-13)4-5-16-6-7-17(10-14(16)2)29-30(26,27)28/h3,6-12H,4-5H2,1-2H3,(H2,23,25)(H2,26,27,28)
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n/an/an/an/a 315n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189287
PNG
(CHEMBL3827413 | US9597326, Compound 11)
Show SMILES COc1ccc(CCc2cnc3c(N)nc4cc(CCP(O)(O)=O)ccc4c3c2)c(C)c1
Show InChI InChI=1S/C24H26N3O4P/c1-15-11-19(31-2)7-6-18(15)5-3-17-12-21-20-8-4-16(9-10-32(28,29)30)13-22(20)27-24(25)23(21)26-14-17/h4,6-8,11-14H,3,5,9-10H2,1-2H3,(H2,25,27)(H2,28,29,30)
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n/an/an/an/a 90n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301803
PNG
(US9597326, Compound 19)
Show SMILES COc1ccc(CCc2cnc3c(N)nc4cc(ccc4c3c2)C(C)(P(O)(O)=O)P(O)(O)=O)c(C)c1
Show InChI InChI=1S/C24H27N3O7P2/c1-14-10-18(34-3)8-6-16(14)5-4-15-11-20-19-9-7-17(24(2,35(28,29)30)36(31,32)33)12-21(19)27-23(25)22(20)26-13-15/h6-13H,4-5H2,1-3H3,(H2,25,27)(H2,28,29,30)(H2,31,32,33)
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n/an/an/an/a 2.38E+4n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189283
PNG
(CHEMBL3828542 | US9597326, Compound 6)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCOCCOCCC(F)(F)P(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C29H34F2N3O6P/c1-19-3-8-24-25-17-21(18-33-27(25)28(32)34-26(24)15-19)4-5-22-6-7-23(16-20(22)2)40-14-13-39-12-11-38-10-9-29(30,31)41(35,36)37/h3,6-8,15-18H,4-5,9-14H2,1-2H3,(H2,32,34)(H2,35,36,37)
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n/an/an/an/a 1.64E+3n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189181
PNG
(CHEMBL3828229 | US9597326, Compound 21)
Show SMILES Cc1cc(OCCOCCOCCP(O)(O)=O)ccc1CCc1cnc2c(N)nc3cc(CCC(O)=O)ccc3c2c1
Show InChI InChI=1S/C30H36N3O8P/c1-20-16-24(41-13-12-39-10-11-40-14-15-42(36,37)38)7-6-23(20)5-2-22-17-26-25-8-3-21(4-9-28(34)35)18-27(25)33-30(31)29(26)32-19-22/h3,6-8,16-19H,2,4-5,9-15H2,1H3,(H2,31,33)(H,34,35)(H2,36,37,38)
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n/an/an/an/a 384n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189285
PNG
(CHEMBL3828296 | US9597326, Compound 5)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCCC(F)(F)P(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C26H28F2N3O4P/c1-16-4-9-21-22-14-18(15-30-24(22)25(29)31-23(21)12-16)5-6-19-7-8-20(13-17(19)2)35-11-3-10-26(27,28)36(32,33)34/h4,7-9,12-15H,3,5-6,10-11H2,1-2H3,(H2,29,31)(H2,32,33,34)
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n/an/an/an/a 308n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189289
PNG
(CHEMBL3828519 | US9597326, Compound 10)
Show SMILES COc1ccc(CCc2cnc3c(N)nc4cc(\C=C\P(O)(O)=O)ccc4c3c2)c(C)c1
Show InChI InChI=1S/C24H24N3O4P/c1-15-11-19(31-2)7-6-18(15)5-3-17-12-21-20-8-4-16(9-10-32(28,29)30)13-22(20)27-24(25)23(21)26-14-17/h4,6-14H,3,5H2,1-2H3,(H2,25,27)(H2,28,29,30)/b10-9+
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n/an/an/an/a 153n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301807
PNG
(US9597326, Compound 23)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCP(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C24H26N3O4P/c1-15-3-8-20-21-13-17(14-26-23(21)24(25)27-22(20)11-15)4-5-18-6-7-19(12-16(18)2)31-9-10-32(28,29)30/h3,6-8,11-14H,4-5,9-10H2,1-2H3,(H2,25,27)(H2,28,29,30)
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n/an/an/an/a 1.16E+3n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189284
PNG
(CHEMBL3828386 | US9597326, Compound 27)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCOCCOCCP(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C28H34N3O6P/c1-19-3-8-24-25-17-21(18-30-27(25)28(29)31-26(24)15-19)4-5-22-6-7-23(16-20(22)2)37-12-11-35-9-10-36-13-14-38(32,33)34/h3,6-8,15-18H,4-5,9-14H2,1-2H3,(H2,29,31)(H2,32,33,34)
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n/an/an/an/a 2.59E+3n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301785
PNG
(US9597326, Compound 4)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCCCC(F)(F)P(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C27H30F2N3O4P/c1-17-5-10-22-23-15-19(16-31-25(23)26(30)32-24(22)13-17)6-7-20-8-9-21(14-18(20)2)36-12-4-3-11-27(28,29)37(33,34)35/h5,8-10,13-16H,3-4,6-7,11-12H2,1-2H3,(H2,30,32)(H2,33,34,35)
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n/an/an/an/a 559n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301806
PNG
(US9597326, Compound 22)
Show SMILES Cc1cc(OCCOCCP(O)(O)=O)ccc1CCc1cnc2c(N)nc3cc(CCC(O)=O)ccc3c2c1
Show InChI InChI=1S/C28H32N3O7P/c1-18-14-22(38-11-10-37-12-13-39(34,35)36)7-6-21(18)5-2-20-15-24-23-8-3-19(4-9-26(32)33)16-25(23)31-28(29)27(24)30-17-20/h3,6-8,14-17H,2,4-5,9-13H2,1H3,(H2,29,31)(H,32,33)(H2,34,35,36)
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n/an/an/an/a 204n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189288
PNG
(CHEMBL3828701 | US9597326, Compound 12)
Show SMILES COc1ccc(CCc2cnc3c(N)nc4cc(\C=C(/F)P(O)(O)=O)ccc4c3c2)c(C)c1
Show InChI InChI=1S/C24H23FN3O4P/c1-14-9-18(32-2)7-6-17(14)5-3-16-10-20-19-8-4-15(12-22(25)33(29,30)31)11-21(19)28-24(26)23(20)27-13-16/h4,6-13H,3,5H2,1-2H3,(H2,26,28)(H2,29,30,31)/b22-12+
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n/an/an/an/a 201n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301804
PNG
(US9597326, Compound 20)
Show SMILES Cc1cc(OCCOCCC(F)(F)P(O)(O)=O)ccc1CCc1cnc2c(N)nc3cc(CCC(O)=O)ccc3c2c1
Show InChI InChI=1S/C29H32F2N3O7P/c1-18-14-22(41-13-12-40-11-10-29(30,31)42(37,38)39)7-6-21(18)5-2-20-15-24-23-8-3-19(4-9-26(35)36)16-25(23)34-28(32)27(24)33-17-20/h3,6-8,14-17H,2,4-5,9-13H2,1H3,(H2,32,34)(H,35,36)(H2,37,38,39)
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n/an/an/an/a 360n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301808
PNG
(US9597326, Compound 24)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCCCCCP(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C28H34N3O4P/c1-19-7-12-24-25-17-21(18-30-27(25)28(29)31-26(24)15-19)8-9-22-10-11-23(16-20(22)2)35-13-5-3-4-6-14-36(32,33)34/h7,10-12,15-18H,3-6,8-9,13-14H2,1-2H3,(H2,29,31)(H2,32,33,34)
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n/an/an/an/a 791n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301809
PNG
(US9597326, Compound 25)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCCCCC(F)(F)P(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C28H32F2N3O4P/c1-18-6-11-23-24-16-20(17-32-26(24)27(31)33-25(23)14-18)7-8-21-9-10-22(15-19(21)2)37-13-5-3-4-12-28(29,30)38(34,35)36/h6,9-11,14-17H,3-5,7-8,12-13H2,1-2H3,(H2,31,33)(H2,34,35,36)
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n/an/an/an/a 4.26E+3n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50189286
PNG
(CHEMBL3827244 | US9597326, Compound 1)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCCP(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C25H28N3O4P/c1-16-4-9-21-22-14-18(15-27-24(22)25(26)28-23(21)12-16)5-6-19-7-8-20(13-17(19)2)32-10-3-11-33(29,30)31/h4,7-9,12-15H,3,5-6,10-11H2,1-2H3,(H2,26,28)(H2,29,30,31)
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n/an/an/an/a 226n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM301788
PNG
(US9597326, Compound 7)
Show SMILES Cc1ccc2c(c1)nc(N)c1ncc(CCc3ccc(OCCOCCC(F)(F)P(O)(O)=O)cc3C)cc21
Show InChI InChI=1S/C27H30F2N3O5P/c1-17-3-8-22-23-15-19(16-31-25(23)26(30)32-24(22)13-17)4-5-20-6-7-21(14-18(20)2)37-12-11-36-10-9-27(28,29)38(33,34)35/h3,6-8,13-16H,4-5,9-12H2,1-2H3,(H2,30,32)(H2,33,34,35)
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n/an/an/an/a 1.01E+3n/an/an/an/a



GlaxoSmithKline Biologicals SA; U.S. Army Medical Research and Materiel Command

US Patent


Assay Description
Human embryonic kidney 293 (HEK 293) cells were stably transfected with human TLR7 and an NF-kB-driven luciferase reporter vector (pNifty-Luciferase)...


US Patent US9597326 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%