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Patent code US9598370

Compile Data Set for Download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 83n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 180n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 190n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
PDB
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n/an/a 240n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107717
PNG
(US8598210, Table XV, 23 | US8722895, 23: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107708
PNG
(US8598210, Table XV, 14 | US8722895, 14: {[5-(4-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301825
PNG
(US9598370, Example 00149)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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n/an/a 400n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 410n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107707
PNG
(US8598210, Table XV, 13 | US8722895, 13: {[5-(4-Is...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 440n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM301799
PNG
(US9598370, Example 00133)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 560n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 650n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107711
PNG
(US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlo...)
Show SMILES CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3/c1-17-13(21)8-19-15(22)14-12(20)6-10(7-18-14)9-3-2-4-11(16)5-9/h2-7,20H,8H2,1H3,(H,17,21)(H,19,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107711
PNG
(US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlo...)
Show SMILES CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3/c1-17-13(21)8-19-15(22)14-12(20)6-10(7-18-14)9-3-2-4-11(16)5-9/h2-7,20H,8H2,1H3,(H,17,21)(H,19,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107709
PNG
(US8598210, Table XV, 15 | US8722895, 15: {[5-(4-Is...)
Show SMILES CC(C)Oc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O5/c1-10(2)24-13-5-3-11(4-6-13)12-7-14(20)16(18-8-12)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107710
PNG
(US8598210, Table XV, 16 | US8722895, 16: {[5-(2-Me...)
Show SMILES Cc1ccc(Cl)cc1-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-8-2-3-10(16)5-11(8)9-4-12(19)14(17-6-9)15(22)18-7-13(20)21/h2-6,19H,7H2,1H3,(H,18,22)(H,20,21)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107716
PNG
(US8598210, Table XV, 22 | US8722895, 22: ({3-Hydro...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H21N3O5/c1-28-17(25)12-22-19(26)18-16(24)10-15(11-21-18)13-5-4-6-14(9-13)20(27)23-7-2-3-8-23/h4-6,9-11,24H,2-3,7-8,12H2,1H3,(H,22,26)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301820
PNG
(US9598370, Example 00144)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C16H14N6O4/c1-26-13(24)8-18-16(25)14-12(23)6-11(7-17-14)9-3-2-4-10(5-9)15-19-21-22-20-15/h2-7,23H,8H2,1H3,(H,18,25)(H,19,20,21,22)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107695
PNG
(US8598210, Table XV, 1 | US8722895, 1: {[5-(3-chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107696
PNG
(US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-2-4-11(16)5-3-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107700
PNG
(US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C16H16N2O4/c1-10-3-5-11(6-4-10)12-7-13(19)15(17-8-12)16(21)18-9-14(20)22-2/h3-8,19H,9H2,1-2H3,(H,18,21)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301819
PNG
(US9598370, Example 00143)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-3-10(5-11)7-17/h2-6,8,20H,9H2,1H3,(H,19,22)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301787
PNG
(US9598370, Example 00128)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-10(7-17)3-5-11/h2-6,8,20H,9H2,1H3,(H,19,22)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107701
PNG
(US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107719
PNG
(US8598210, Table XV, 25 | US8722895, 25: ({5-[3-(c...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C19H19N3O5/c1-27-16(24)10-21-19(26)17-15(23)8-13(9-20-17)12-3-2-4-14(7-12)22-18(25)11-5-6-11/h2-4,7-9,11,23H,5-6,10H2,1H3,(H,21,26)(H,22,25)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107715
PNG
(US8598210, Table XV, 21 | US8722895, 21: {[5-(3-Ca...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C16H15N3O5/c1-24-13(21)8-19-16(23)14-12(20)6-11(7-18-14)9-3-2-4-10(5-9)15(17)22/h2-7,20H,8H2,1H3,(H2,17,22)(H,19,23)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107699
PNG
(US8598210, Table XV, 5 | US8722895, 5: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1ccc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C16H15NO4/c1-10-2-4-11(5-3-10)12-6-7-13(14(18)8-12)16(21)17-9-15(19)20/h2-8,18H,9H2,1H3,(H,17,21)(H,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107695
PNG
(US8598210, Table XV, 1 | US8722895, 1: {[5-(3-chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 2.14E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107701
PNG
(US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 3.75E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107700
PNG
(US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C16H16N2O4/c1-10-3-5-11(6-4-10)12-7-13(19)15(17-8-12)16(21)18-9-14(20)22-2/h3-8,19H,9H2,1-2H3,(H,18,21)
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n/an/a 5.23E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301799
PNG
(US9598370, Example 00133)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 9.90E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107717
PNG
(US8598210, Table XV, 23 | US8722895, 23: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM301820
PNG
(US9598370, Example 00144)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C16H14N6O4/c1-26-13(24)8-18-16(25)14-12(23)6-11(7-17-14)9-3-2-4-10(5-9)15-19-21-22-20-15/h2-7,23H,8H2,1H3,(H,18,25)(H,19,20,21,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107707
PNG
(US8598210, Table XV, 13 | US8722895, 13: {[5-(4-Is...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/an/an/a 1.50E+4n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107715
PNG
(US8598210, Table XV, 21 | US8722895, 21: {[5-(3-Ca...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C16H15N3O5/c1-24-13(21)8-19-16(23)14-12(20)6-11(7-18-14)9-3-2-4-10(5-9)15(17)22/h2-7,20H,8H2,1H3,(H2,17,22)(H,19,23)
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n/an/an/an/a 5.01E+4n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107711
PNG
(US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlo...)
Show SMILES CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3/c1-17-13(21)8-19-15(22)14-12(20)6-10(7-18-14)9-3-2-4-11(16)5-9/h2-7,20H,8H2,1H3,(H,17,21)(H,19,22)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107710
PNG
(US8598210, Table XV, 16 | US8722895, 16: {[5-(2-Me...)
Show SMILES Cc1ccc(Cl)cc1-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-8-2-3-10(16)5-11(8)9-4-12(19)14(17-6-9)15(22)18-7-13(20)21/h2-6,19H,7H2,1H3,(H,18,22)(H,20,21)
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n/an/an/an/a 3.30E+3n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107716
PNG
(US8598210, Table XV, 22 | US8722895, 22: ({3-Hydro...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H21N3O5/c1-28-17(25)12-22-19(26)18-16(24)10-15(11-21-18)13-5-4-6-14(9-13)20(27)23-7-2-3-8-23/h4-6,9-11,24H,2-3,7-8,12H2,1H3,(H,22,26)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM301825
PNG
(US9598370, Example 00149)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107699
PNG
(US8598210, Table XV, 5 | US8722895, 5: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1ccc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C16H15NO4/c1-10-2-4-11(5-3-10)12-6-7-13(14(18)8-12)16(21)17-9-15(19)20/h2-8,18H,9H2,1H3,(H,17,21)(H,19,20)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107709
PNG
(US8598210, Table XV, 15 | US8722895, 15: {[5-(4-Is...)
Show SMILES CC(C)Oc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O5/c1-10(2)24-13-5-3-11(4-6-13)12-7-14(20)16(18-8-12)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107701
PNG
(US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/an/an/a 7.70E+3n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/an/an/a 4.21E+4n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107695
PNG
(US8598210, Table XV, 1 | US8722895, 1: {[5-(3-chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/an/an/a 9.90E+3n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/an/an/a 7.60E+3n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM301787
PNG
(US9598370, Example 00128)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-10(7-17)3-5-11/h2-6,8,20H,9H2,1H3,(H,19,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM301799
PNG
(US9598370, Example 00133)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/an/an/a 4.30E+3n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107700
PNG
(US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C16H16N2O4/c1-10-3-5-11(6-4-10)12-7-13(19)15(17-8-12)16(21)18-9-14(20)22-2/h3-8,19H,9H2,1-2H3,(H,18,21)
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n/an/an/an/a 8.20E+3n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107696
PNG
(US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-2-4-11(16)5-3-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM301819
PNG
(US9598370, Example 00143)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-3-10(5-11)7-17/h2-6,8,20H,9H2,1H3,(H,19,22)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107708
PNG
(US8598210, Table XV, 14 | US8722895, 14: {[5-(4-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%