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Patent code US9598410

Compile Data Set for Download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179693
PNG
(US9127001, 8b | US9598410, Compound 8b)
Show SMILES CC(C)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C24H22F2N4O/c1-15(2)24(31)29-9-8-22-20(14-29)23(17-5-3-4-16(10-17)12-27)28-30(22)13-18-6-7-19(25)11-21(18)26/h3-7,10-11,15H,8-9,13-14H2,1-2H3
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US Patent
n/an/a 19n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179694
PNG
(US9127001, 8c | US9598410, Compound 8c)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CC2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C24H20F2N4O/c25-19-7-6-18(21(26)11-19)13-30-22-8-9-29(24(31)16-4-5-16)14-20(22)23(28-30)17-3-1-2-15(10-17)12-27/h1-3,6-7,10-11,16H,4-5,8-9,13-14H2
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US Patent
n/an/a 47n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179702
PNG
(US9127001, 8i | US9598410, Compound 8i)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCC2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C25H22F2N4O/c26-20-8-7-19(22(27)12-20)14-31-23-9-10-30(25(32)17-4-2-5-17)15-21(23)24(29-31)18-6-1-3-16(11-18)13-28/h1,3,6-8,11-12,17H,2,4-5,9-10,14-15H2
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n/an/a 64n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179635
PNG
(US9127001, 6n | US9598410, Compound 6n)
Show SMILES CC(=O)N1C2CCC1c1c(C2)n(Cc2ccc(F)cc2F)nc1-c1cccc(c1)C#N
Show InChI InChI=1S/C24H20F2N4O/c1-14(31)30-19-7-8-21(30)23-22(11-19)29(13-17-5-6-18(25)10-20(17)26)28-24(23)16-4-2-3-15(9-16)12-27/h2-6,9-10,19,21H,7-8,11,13H2,1H3
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n/an/a 91n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179623
PNG
(US9127001, 6a | US9598410, Compound 6a)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C22H18F2N4O/c1-14(29)27-8-7-21-19(13-27)22(16-4-2-3-15(9-16)11-25)26-28(21)12-17-5-6-18(23)10-20(17)24/h2-6,9-10H,7-8,12-13H2,1H3
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n/an/a 95n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179629
PNG
(US9127001, 6g | US9598410, Compound 6g)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C21H18F4N4O/c1-13(30)28-10-9-18-16(12-28)20(17-3-2-4-19(26-17)21(23,24)25)27-29(18)11-14-5-7-15(22)8-6-14/h2-8H,9-12H2,1H3
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n/an/a 99.5n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179659
PNG
(US9127001, 6am | US9598410, Compound 6am)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(cc1)C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N4O/c1-15(31)29-10-9-21-20(14-29)22(18-3-2-4-19(11-18)23(24,25)26)28-30(21)13-17-7-5-16(12-27)6-8-17/h2-8,11H,9-10,13-14H2,1H3
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n/an/a 114n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179708
PNG
(US9127001, 8o | US9598410, Compound 8o)
Show SMILES CC(C)(C)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C25H24F2N4O/c1-25(2,3)24(32)30-10-9-22-20(15-30)23(17-6-4-5-16(11-17)13-28)29-31(22)14-18-7-8-19(26)12-21(18)27/h4-8,11-12H,9-10,14-15H2,1-3H3
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n/an/a 131n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179624
PNG
(US9127001, 6b | US9598410, Compound 6b)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(Cl)nc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N4O/c1-13(30)28-8-7-18-17(12-28)20(15-3-2-4-16(9-15)21(23,24)25)27-29(18)11-14-5-6-19(22)26-10-14/h2-6,9-10H,7-8,11-12H2,1H3
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n/an/a 172n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179660
PNG
(US9127001, 6an | US9598410, Compound 6an)
Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(C)=O)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H21FN4O/c1-15(18-6-8-20(24)9-7-18)28-22-10-11-27(16(2)29)14-21(22)23(26-28)19-5-3-4-17(12-19)13-25/h3-9,12,15H,10-11,14H2,1-2H3
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n/an/a 187n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179630
PNG
(US9127001, 6h | US9598410, Compound 6h)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C21H17F5N4O/c1-12(31)29-7-5-19-16(11-29)20(18-8-14(4-6-27-18)21(24,25)26)28-30(19)10-13-2-3-15(22)9-17(13)23/h2-4,6,8-9H,5,7,10-11H2,1H3
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n/an/a 190n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179625
PNG
(US9127001, 6c | US9598410, Compound 6c)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1cnccc1Cl)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18ClF3N4O/c1-13(30)28-8-6-19-17(12-28)20(14-3-2-4-16(9-14)21(23,24)25)27-29(19)11-15-10-26-7-5-18(15)22/h2-5,7,9-10H,6,8,11-12H2,1H3
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n/an/a 215n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179631
PNG
(US9127001, 6i | US9598410, Compound 6i)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C21H17F5N4O/c1-12(31)29-8-7-18-15(11-29)20(17-3-2-4-19(27-17)21(24,25)26)28-30(18)10-13-5-6-14(22)9-16(13)23/h2-6,9H,7-8,10-11H2,1H3
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n/an/a 216n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179713
PNG
(US9127001, 8t | US9598410, Compound 8t)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)c2ccccn2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C26H19F2N5O/c27-20-8-7-19(22(28)13-20)15-33-24-9-11-32(26(34)23-6-1-2-10-30-23)16-21(24)25(31-33)18-5-3-4-17(12-18)14-29/h1-8,10,12-13H,9,11,15-16H2
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n/an/a 246n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179683
PNG
(US9127001, 6bl | US9127001, 6bm | US9598410, Compo...)
Show SMILES CCC(c1ccc(Cl)cc1)n1nc(c2CN(CCc12)C(C)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23ClFN3O/c1-3-21(16-4-8-18(24)9-5-16)28-22-12-13-27(15(2)29)14-20(22)23(26-28)17-6-10-19(25)11-7-17/h4-11,21H,3,12-14H2,1-2H3
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n/an/a 251n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179661
PNG
(US9127001, 6ao | US9598410, Compound 6ao)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2C(C1CC1)c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H23F2N3O/c1-15(30)28-13-12-22-21(14-28)23(16-4-8-19(25)9-5-16)27-29(22)24(17-2-3-17)18-6-10-20(26)11-7-18/h4-11,17,24H,2-3,12-14H2,1H3
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n/an/a 258n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179657
PNG
(US9127001, 6ak | US9598410, Compound 6ak)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1ccc(Cl)s1
Show InChI InChI=1S/C19H16ClF2N3OS/c1-11(26)24-7-6-16-14(10-24)19(17-4-5-18(20)27-17)23-25(16)9-12-2-3-13(21)8-15(12)22/h2-5,8H,6-7,9-10H2,1H3
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n/an/a 270n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179692
PNG
(US9127001, 8a | US9598410, Compound 8a)
Show SMILES CC1(COC1)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C25H22F2N4O2/c1-25(14-33-15-25)24(32)30-8-7-22-20(13-30)23(17-4-2-3-16(9-17)11-28)29-31(22)12-18-5-6-19(26)10-21(18)27/h2-6,9-10H,7-8,12-15H2,1H3
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n/an/a 276n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179662
PNG
(US9127001, 6ap | US9598410, Compound 6ap)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C22H18F5N3O2/c1-13(31)29-8-7-20-18(12-29)21(14-3-2-4-17(9-14)32-22(25,26)27)28-30(20)11-15-5-6-16(23)10-19(15)24/h2-6,9-10H,7-8,11-12H2,1H3
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n/an/a 285n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179663
PNG
(US9127001, 6aq | US9598410, Compound 6aq)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1c(F)cccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C21H18F3N3O/c1-13(28)26-10-9-20-17(11-26)21(14-5-7-15(22)8-6-14)25-27(20)12-16-18(23)3-2-4-19(16)24/h2-8H,9-12H2,1H3
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n/an/a 359n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179725
PNG
(US9127001, 12a | US9598410, Compound 12a)
Show SMILES CNC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C22H19F2N5O/c1-26-22(30)28-8-7-20-18(13-28)21(15-4-2-3-14(9-15)11-25)27-29(20)12-16-5-6-17(23)10-19(16)24/h2-6,9-10H,7-8,12-13H2,1H3,(H,26,30)
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n/an/a 380n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179678
PNG
(US9127001, 6bg | US9598410, Compound 6bg)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(Cl)c(F)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H18ClF2N3O/c1-13(28)26-9-8-20-17(12-26)21(15-3-5-16(23)6-4-15)25-27(20)11-14-2-7-18(22)19(24)10-14/h2-7,10H,8-9,11-12H2,1H3
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n/an/a 398n/an/an/an/an/an/a



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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179714
PNG
(US9127001, 8u | US9598410, Compound 8u)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)c2ccncc2F)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C26H18F3N5O/c27-19-5-4-18(22(28)11-19)14-34-24-7-9-33(26(35)20-6-8-31-13-23(20)29)15-21(24)25(32-34)17-3-1-2-16(10-17)12-30/h1-6,8,10-11,13H,7,9,14-15H2
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n/an/a 416n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179626
PNG
(US9127001, 6d | US9598410, Compound 6d)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ncccc1C)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O/c1-14-5-4-9-26-19(14)13-29-20-8-10-28(15(2)30)12-18(20)21(27-29)16-6-3-7-17(11-16)22(23,24)25/h3-7,9,11H,8,10,12-13H2,1-2H3
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n/an/a 422n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179730
PNG
(US9127001, 13a | US9598410, Compound 13a)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cc(ccn1)C#N
Show InChI InChI=1S/C21H17F2N5O/c1-13(29)27-7-5-20-17(12-27)21(19-8-14(10-24)4-6-25-19)26-28(20)11-15-2-3-16(22)9-18(15)23/h2-4,6,8-9H,5,7,11-12H2,1H3
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n/an/a 422n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179731
PNG
(US9127001, 13b | US9598410, Compound 13b)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(n1)C#N
Show InChI InChI=1S/C21H17F2N5O/c1-13(29)27-8-7-20-17(12-27)21(19-4-2-3-16(10-24)25-19)26-28(20)11-14-5-6-15(22)9-18(14)23/h2-6,9H,7-8,11-12H2,1H3
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n/an/a 462n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179664
PNG
(US9127001, 6ar | US9127001, 6be | US9127001, 6bf |...)
Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(C)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21F2N3O/c1-14(16-3-7-18(23)8-4-16)27-21-11-12-26(15(2)28)13-20(21)22(25-27)17-5-9-19(24)10-6-17/h3-10,14H,11-13H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179664
PNG
(US9127001, 6ar | US9127001, 6be | US9127001, 6bf |...)
Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(C)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21F2N3O/c1-14(16-3-7-18(23)8-4-16)27-21-11-12-26(15(2)28)13-20(21)22(25-27)17-5-9-19(24)10-6-17/h3-10,14H,11-13H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179697
PNG
(US9127001, 8z | US9598410, Compound 8z)
Show SMILES CC1Cc2c(CN1C(C)=O)c(nn2Cc1ccc(F)cc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C22H20F3N3O/c1-13-9-21-19(12-27(13)14(2)29)22(15-3-6-17(23)7-4-15)26-28(21)11-16-5-8-18(24)10-20(16)25/h3-8,10,13H,9,11-12H2,1-2H3
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n/an/a 511n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179726
PNG
(US9127001, 12b | US9598410, Compound 12b)
Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(=O)N1CCOCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H26F2N4O2/c1-17(18-2-6-20(26)7-3-18)31-23-10-11-30(25(32)29-12-14-33-15-13-29)16-22(23)24(28-31)19-4-8-21(27)9-5-19/h2-9,17H,10-16H2,1H3
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n/an/a 511n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179709
PNG
(US9127001, 8p | US9598410, Compound 8p)
Show SMILES CCC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H20F2N4O/c1-2-22(30)28-9-8-21-19(14-28)23(16-5-3-4-15(10-16)12-26)27-29(21)13-17-6-7-18(24)11-20(17)25/h3-7,10-11H,2,8-9,13-14H2,1H3
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n/an/a 530n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM302143
PNG
(3-(4-Fluoro-phenyl)-1-[(R)-1-(4-fluoro-phenyl)-eth...)
Show SMILES C[C@H](c1ccc(F)cc1)n1nc(c2CN(CCc12)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C21H21F2N3O2S/c1-14(15-3-7-17(22)8-4-15)26-20-11-12-25(29(2,27)28)13-19(20)21(24-26)16-5-9-18(23)10-6-16/h3-10,14H,11-13H2,1-2H3/t14-/m1/s1
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n/an/a 540n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179664
PNG
(US9127001, 6ar | US9127001, 6be | US9127001, 6bf |...)
Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(C)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21F2N3O/c1-14(16-3-7-18(23)8-4-16)27-21-11-12-26(15(2)28)13-20(21)22(25-27)17-5-9-19(24)10-6-17/h3-10,14H,11-13H2,1-2H3
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n/an/a 552n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179705
PNG
(US9127001, 8l | US9598410, Compound 8l)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCOCC2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C26H24F2N4O2/c27-21-5-4-20(23(28)13-21)15-32-24-6-9-31(26(33)18-7-10-34-11-8-18)16-22(24)25(30-32)19-3-1-2-17(12-19)14-29/h1-5,12-13,18H,6-11,15-16H2
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n/an/a 585n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179628
PNG
(US9127001, 6f | US9598410, Compound 6f)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C21H18F3N3O/c1-13(28)26-9-8-20-18(12-26)21(14-2-5-16(22)6-3-14)25-27(20)11-15-4-7-17(23)10-19(15)24/h2-7,10H,8-9,11-12H2,1H3
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n/an/a 598n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM302144
PNG
(3-(4-Fluoro-phenyl)-1-[(R)-1-(4-fluoro-phenyl)-eth...)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nc(c2CN(CCc12)S(C)(=O)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C21H21F2N3O2S/c1-14(15-3-7-17(22)8-4-15)26-20-11-12-25(29(2,27)28)13-19(20)21(24-26)16-5-9-18(23)10-6-16/h3-10,14H,11-13H2,1-2H3/t14-/m0/s1
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n/an/a 611n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179665
PNG
(US9127001, 6as | US9598410, Compound 6as)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(cc1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19F4N3O/c1-14(30)28-11-10-20-19(13-28)21(16-4-8-18(23)9-5-16)27-29(20)12-15-2-6-17(7-3-15)22(24,25)26/h2-9H,10-13H2,1H3
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n/an/a 659n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179666
PNG
(US9127001, 6at | US9598410, Compound 6at)
Show SMILES COc1cccc(c1)-c1nn(Cc2ccc(F)cc2F)c2CCN(Cc12)C(C)=O
Show InChI InChI=1S/C22H21F2N3O2/c1-14(28)26-9-8-21-19(13-26)22(15-4-3-5-18(10-15)29-2)25-27(21)12-16-6-7-17(23)11-20(16)24/h3-7,10-11H,8-9,12-13H2,1-2H3
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n/an/a 720n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179703
PNG
(US9127001, 8j | US9598410, Compound 8j)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCCC2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C26H24F2N4O/c27-21-9-8-20(23(28)13-21)15-32-24-10-11-31(26(33)18-5-1-2-6-18)16-22(24)25(30-32)19-7-3-4-17(12-19)14-29/h3-4,7-9,12-13,18H,1-2,5-6,10-11,15-16H2
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n/an/a 722n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179727
PNG
(US9127001, 12c | US9598410, Compound 12c)
Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(=O)N1CC[C@H](O)C1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H26F2N4O2/c1-16(17-2-6-19(26)7-3-17)31-23-11-13-30(25(33)29-12-10-21(32)14-29)15-22(23)24(28-31)18-4-8-20(27)9-5-18/h2-9,16,21,32H,10-15H2,1H3/t16?,21-/m0/s1
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n/an/a 734n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179710
PNG
(US9127001, 8q | US9598410, Compound 8q)
Show SMILES C[C@H](O)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H20F2N4O2/c1-14(30)23(31)28-8-7-21-19(13-28)22(16-4-2-3-15(9-16)11-26)27-29(21)12-17-5-6-18(24)10-20(17)25/h2-6,9-10,14,30H,7-8,12-13H2,1H3/t14-/m0/s1
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n/an/a 756n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179715
PNG
(US9127001, 8v | US9598410, Compound 8v)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)c2ccncn2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C25H18F2N6O/c26-19-5-4-18(21(27)11-19)13-33-23-7-9-32(25(34)22-6-8-29-15-30-22)14-20(23)24(31-33)17-3-1-2-16(10-17)12-28/h1-6,8,10-11,15H,7,9,13-14H2
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n/an/a 864n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179706
PNG
(US9127001, 8m | US9598410, Compound 8m)
Show SMILES Fc1ccc(Cn2nc(c3CN(CCc23)C(=O)C2CCOC2)-c2cccc(c2)C#N)c(F)c1
Show InChI InChI=1S/C25H22F2N4O2/c26-20-5-4-18(22(27)11-20)13-31-23-6-8-30(25(32)19-7-9-33-15-19)14-21(23)24(29-31)17-3-1-2-16(10-17)12-28/h1-5,10-11,19H,6-9,13-15H2
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n/an/a 890n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179704
PNG
(US9127001, 8k | US9598410, Compound 8k)
Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H22F2N4O3S/c1-38(36,37)23-9-6-19(7-10-23)28(35)33-12-11-26-24(17-33)27(20-4-2-3-18(13-20)15-31)32-34(26)16-21-5-8-22(29)14-25(21)30/h2-10,13-14H,11-12,16-17H2,1H3
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n/an/a 906n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179667
PNG
(US9127001, 6av | US9598410, Compound 6av)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1cccc(c1)C(F)(F)F)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19F4N3O/c1-14(30)28-10-9-20-19(13-28)21(16-5-7-18(23)8-6-16)27-29(20)12-15-3-2-4-17(11-15)22(24,25)26/h2-8,11H,9-10,12-13H2,1H3
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n/an/a 911n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179668
PNG
(US9127001, 6aw | US9598410, Compound 6aw)
Show SMILES CC(c1ccc(F)cc1)n1nc(c2CN(CCc12)C(C)=O)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H21F4N3O2/c1-14(16-6-8-18(24)9-7-16)30-21-10-11-29(15(2)31)13-20(21)22(28-30)17-4-3-5-19(12-17)32-23(25,26)27/h3-9,12,14H,10-11,13H2,1-2H3
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n/an/a 947n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179683
PNG
(US9127001, 6bl | US9127001, 6bm | US9598410, Compo...)
Show SMILES CCC(c1ccc(Cl)cc1)n1nc(c2CN(CCc12)C(C)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23ClFN3O/c1-3-21(16-4-8-18(24)9-5-16)28-22-12-13-27(15(2)29)14-20(22)23(26-28)17-6-10-19(25)11-7-17/h4-11,21H,3,12-14H2,1-2H3
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n/an/a 966n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179669
PNG
(US9127001, 6ax | US9598410, Compound 6ax)
Show SMILES COc1cc(ccc1F)-c1nn(Cc2ccc(F)cc2F)c2CCN(Cc12)C(C)=O
Show InChI InChI=1S/C22H20F3N3O2/c1-13(29)27-8-7-20-17(12-27)22(14-4-6-18(24)21(9-14)30-2)26-28(20)11-15-3-5-16(23)10-19(15)25/h3-6,9-10H,7-8,11-12H2,1-2H3
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n/an/a 975n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179711
PNG
(US9127001, 8r | US9598410, Compound 8r)
Show SMILES Fc1ccc(cc1)-c1nn(Cc2ccccc2)c2CCN(Cc12)C(=O)Cc1ccccc1
Show InChI InChI=1S/C27H24FN3O/c28-23-13-11-22(12-14-23)27-24-19-30(26(32)17-20-7-3-1-4-8-20)16-15-25(24)31(29-27)18-21-9-5-2-6-10-21/h1-14H,15-19H2
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n/an/a 1.14E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179696
PNG
(US9127001, 8w | US9598410, Compound 8w)
Show SMILES Cn1cncc1C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C25H20F2N6O/c1-31-15-29-12-23(31)25(34)32-8-7-22-20(14-32)24(17-4-2-3-16(9-17)11-28)30-33(22)13-18-5-6-19(26)10-21(18)27/h2-6,9-10,12,15H,7-8,13-14H2,1H3
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n/an/a 1.15E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179682
PNG
(US9127001, 6bk | US9598410, Compound 6bk)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H18F5N3O/c1-13(31)29-9-8-20-18(12-29)21(14-2-5-16(6-3-14)22(25,26)27)28-30(20)11-15-4-7-17(23)10-19(15)24/h2-7,10H,8-9,11-12H2,1H3
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n/an/a 1.15E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179681
PNG
(US9127001, 6bj | US9598410, Compound 6bj)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(F)c1
Show InChI InChI=1S/C21H18F3N3O/c1-13(28)26-8-7-20-18(12-26)21(14-3-2-4-16(22)9-14)25-27(20)11-15-5-6-17(23)10-19(15)24/h2-6,9-10H,7-8,11-12H2,1H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179721
PNG
(US9127001, 11b | US9127001, 11c | US9598410, Compo...)
Show SMILES CCNC(=O)N1CCc2c(C1)c(nn2C(C)c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H24F2N4O/c1-3-26-23(30)28-13-12-21-20(14-28)22(17-6-10-19(25)11-7-17)27-29(21)15(2)16-4-8-18(24)9-5-16/h4-11,15H,3,12-14H2,1-2H3,(H,26,30)
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n/an/a 1.17E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179699
PNG
(US9127001, 8f | US9598410, Compound 8f)
Show SMILES Fc1ccc(cc1)C(=O)N1CCc2c(C1)c(nn2Cc1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H21F2N3O/c27-21-10-6-19(7-11-21)25-23-17-30(26(32)20-8-12-22(28)13-9-20)15-14-24(23)31(29-25)16-18-4-2-1-3-5-18/h1-13H,14-17H2
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n/an/a 1.28E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179721
PNG
(US9127001, 11b | US9127001, 11c | US9598410, Compo...)
Show SMILES CCNC(=O)N1CCc2c(C1)c(nn2C(C)c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H24F2N4O/c1-3-26-23(30)28-13-12-21-20(14-28)22(17-6-10-19(25)11-7-17)27-29(21)15(2)16-4-8-18(24)9-5-16/h4-11,15H,3,12-14H2,1-2H3,(H,26,30)
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n/an/a 1.52E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179698
PNG
(US9127001, 8e | US9598410, Compound 8e)
Show SMILES CS(=O)(=O)c1cccc(c1)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C28H22F2N4O3S/c1-38(36,37)23-7-3-6-20(13-23)28(35)33-11-10-26-24(17-33)27(19-5-2-4-18(12-19)15-31)32-34(26)16-21-8-9-22(29)14-25(21)30/h2-9,12-14H,10-11,16-17H2,1H3
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n/an/a 1.63E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179680
PNG
(US9127001, 6bi | US9598410, Compound 6bi)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1ccc(F)c(c1)C#N
Show InChI InChI=1S/C22H17F3N4O/c1-13(30)28-7-6-21-18(12-28)22(14-3-5-19(24)16(8-14)10-26)27-29(21)11-15-2-4-17(23)9-20(15)25/h2-5,8-9H,6-7,11-12H2,1H3
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n/an/a 1.65E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179716
PNG
(US9127001, 8x | US9598410, Compound 8x)
Show SMILES Cn1ccc(n1)C(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C25H20F2N6O/c1-31-9-7-22(29-31)25(34)32-10-8-23-20(15-32)24(17-4-2-3-16(11-17)13-28)30-33(23)14-18-5-6-19(26)12-21(18)27/h2-7,9,11-12H,8,10,14-15H2,1H3
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n/an/a 1.88E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179701
PNG
(US9127001, 8h | US9598410, Compound 8h)
Show SMILES Fc1ccc(cc1)-c1nn(Cc2ccccc2)c2CCN(Cc12)C(=O)c1ccccc1
Show InChI InChI=1S/C26H22FN3O/c27-22-13-11-20(12-14-22)25-23-18-29(26(31)21-9-5-2-6-10-21)16-15-24(23)30(28-25)17-19-7-3-1-4-8-19/h1-14H,15-18H2
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n/an/a 2.40E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179634
PNG
(US9127001, 6m | US9598410, Compound 6m)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cncc(Br)c1
Show InChI InChI=1S/C20H17BrF2N4O/c1-12(28)26-5-4-19-17(11-26)20(14-6-15(21)9-24-8-14)25-27(19)10-13-2-3-16(22)7-18(13)23/h2-3,6-9H,4-5,10-11H2,1H3
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n/an/a 2.44E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179700
PNG
(US9127001, 8g | US9598410, Compound 8g)
Show SMILES COc1ccc(cc1)C(=O)N1CCc2c(C1)c(nn2Cc1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C27H24FN3O2/c1-33-23-13-9-21(10-14-23)27(32)30-16-15-25-24(18-30)26(20-7-11-22(28)12-8-20)29-31(25)17-19-5-3-2-4-6-19/h2-14H,15-18H2,1H3
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n/an/a 3.26E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179632
PNG
(US9127001, 6j | US9598410, Compound 6j)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cc(Br)ccn1
Show InChI InChI=1S/C20H17BrF2N4O/c1-12(28)26-7-5-19-16(11-26)20(18-8-14(21)4-6-24-18)25-27(19)10-13-2-3-15(22)9-17(13)23/h2-4,6,8-9H,5,7,10-11H2,1H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179679
PNG
(US9127001, 6bh | US9598410, Compound 6bh)
Show SMILES COc1ccc(F)c(c1)-c1nn(Cc2ccc(F)cc2F)c2CCN(Cc12)C(C)=O
Show InChI InChI=1S/C22H20F3N3O2/c1-13(29)27-8-7-21-18(12-27)22(17-10-16(30-2)5-6-19(17)24)26-28(21)11-14-3-4-15(23)9-20(14)25/h3-6,9-10H,7-8,11-12H2,1-2H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179732
PNG
(US9127001, 14a | US9598410, Compound 14a)
Show SMILES OCC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C22H18F2N4O2/c23-17-5-4-16(19(24)9-17)11-28-20-6-7-27(21(30)13-29)12-18(20)22(26-28)15-3-1-2-14(8-15)10-25/h1-5,8-9,29H,6-7,11-13H2
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n/an/a<1.00E+4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179712
PNG
(US9127001, 8s | US9598410, Compound 8s)
Show SMILES CCCC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(c1)C#N
Show InChI InChI=1S/C24H22F2N4O/c1-2-4-23(31)29-10-9-22-20(15-29)24(17-6-3-5-16(11-17)13-27)28-30(22)14-18-7-8-19(25)12-21(18)26/h3,5-8,11-12H,2,4,9-10,14-15H2,1H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179644
PNG
(US9127001, 6w | US9598410, Compound 6w)
Show SMILES CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(F)cc1F)-c1cccc(Br)n1
Show InChI InChI=1S/C20H17BrF2N4O/c1-12(28)26-8-7-18-15(11-26)20(17-3-2-4-19(21)24-17)25-27(18)10-13-5-6-14(22)9-16(13)23/h2-6,9H,7-8,10-11H2,1H3
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PC cid
PC sid
UniChem

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US Patent
n/an/a<1.00E+4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179675
PNG
(US9127001, 6bd | US9598410, Compound 6bd)
Show SMILES COc1cccc(Cn2nc(c3CN(CCc23)C(C)=O)-c2cccc(Cl)c2)c1
Show InChI InChI=1S/C22H22ClN3O2/c1-15(27)25-10-9-21-20(14-25)22(17-6-4-7-18(23)12-17)24-26(21)13-16-5-3-8-19(11-16)28-2/h3-8,11-12H,9-10,13-14H2,1-2H3
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UniProtKB/SwissProt

DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<1.00E+4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
Potassium channel protein TASK-1


(Homo sapiens (Human))
BDBM179636
PNG
(US9127001, 6o | US9598410, Compound 6o)
Show SMILES CC(=O)N1C2CCC1c1c(C2)n(Cc2ccc(F)cc2F)nc1-c1ccc(F)cc1
Show InChI InChI=1S/C23H20F3N3O/c1-13(30)29-18-8-9-20(29)22-21(11-18)28(12-15-4-7-17(25)10-19(15)26)27-23(22)14-2-5-16(24)6-3-14/h2-7,10,18,20H,8-9,11-12H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<1.00E+4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliated. Subsequently, TA...


US Patent US9598410 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%