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Patent code US9598411

Compile Data Set for Download or QSAR
Found 172 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (human))
BDBM172430
PNG
(US9090618, ZA53 | US9598411, Ref. No. ZA53)
Show SMILES O=C1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)N1
Show InChI InChI=1S/C30H42N4O/c35-30-13-12-22(31-30)17-29-32-27-10-3-4-11-28(27)34(29)26-18-23-8-5-9-24(19-26)33(23)25-15-20-6-1-2-7-21(14-20)16-25/h3-4,10-11,20-26H,1-2,5-9,12-19H2,(H,31,35)/t20-,21+,22-,23-,24+,25-,26+/m0/s1
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US Patent
0.800n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172419
PNG
(US9090618, ZA42 | US9598411, Ref. No. ZA42)
Show SMILES COc1cnc(cn1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H39N5O/c1-36-29-19-31-27(18-32-29)30-33-26-11-4-5-12-28(26)35(30)25-16-22-9-6-10-23(17-25)34(22)24-14-20-7-2-3-8-21(13-20)15-24/h4-5,11-12,18-25H,2-3,6-10,13-17H2,1H3/t20-,21+,22-,23+,24-,25+
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0.920n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172418
PNG
(US9090618, ZA41 | US9598411, Ref. No. ZA41)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1cnccn1
Show InChI InChI=1S/C29H37N5/c1-2-7-21-14-20(6-1)15-24(16-21)33-22-8-5-9-23(33)18-25(17-22)34-28-11-4-3-10-26(28)32-29(34)27-19-30-12-13-31-27/h3-4,10-13,19-25H,1-2,5-9,14-18H2/t20-,21+,22-,23+,24-,25+
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1.15n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172382
PNG
(US9090618, H27b(i) | US9598411, Ref. No. H27b(i))
Show SMILES C1CNC(C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C29H42N4/c1-2-8-21-15-20(7-1)16-24(17-21)32-22-9-5-10-23(32)19-25(18-22)33-28-13-4-3-11-26(28)31-29(33)27-12-6-14-30-27/h3-4,11,13,20-25,27,30H,1-2,5-10,12,14-19H2/t20-,21+,22-,23+,24-,25+,27?
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1.90n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172433
PNG
(US9090618, ZA56 | US9598411, Ref. No. ZA56)
Show SMILES C([C@@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m1/s1
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2.05n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172417
PNG
(US9090618, ZA40 | US9598411, Ref. No. ZA40)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1nnc[nH]1
Show InChI InChI=1S/C27H36N6/c1-2-7-19-12-18(6-1)13-22(14-19)32-20-8-5-9-21(32)16-23(15-20)33-25-11-4-3-10-24(25)30-27(33)26-28-17-29-31-26/h3-4,10-11,17-23H,1-2,5-9,12-16H2,(H,28,29,31)/t18-,19+,20-,21+,22-,23+
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2.20n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172413
PNG
(US9090618, ZA35 | US9598411, Ref. No. ZA35)
Show SMILES OCc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C25H35N3O/c29-16-25-26-23-9-1-2-10-24(23)28(25)22-14-19-7-4-8-20(15-22)27(19)21-12-17-5-3-6-18(11-17)13-21/h1-2,9-10,17-22,29H,3-8,11-16H2/t17-,18+,19-,20+,21+,22?
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2.68n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172438
PNG
(US9090618, ZA61 | US9598411, Ref. No. ZA61)
Show SMILES Cc1nnc(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)[nH]1
Show InChI InChI=1S/C29H40N6/c1-19-30-28(33-32-19)18-29-31-26-11-4-5-12-27(26)35(29)25-16-22-9-6-10-23(17-25)34(22)24-14-20-7-2-3-8-21(13-20)15-24/h4-5,11-12,20-25H,2-3,6-10,13-18H2,1H3,(H,30,32,33)/t20-,21+,22-,23+,24-,25+
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3.80n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172440
PNG
(US9090618, ZA63 | US9598411, Ref. No. ZA63)
Show SMILES COc1cnc(cn1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C29H37N5O/c1-35-28-18-30-26(17-31-28)29-32-25-10-2-3-11-27(25)34(29)24-15-21-8-5-9-22(16-24)33(21)23-13-19-6-4-7-20(12-19)14-23/h2-3,10-11,17-24H,4-9,12-16H2,1H3/t19-,20+,21-,22+,23+,24+
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4.11n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172444
PNG
(US9090618, ZA67 | US9598411, Ref. No. ZA67)
Show SMILES Cc1cc(no1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C28H36N4O/c1-18-12-26(30-33-18)28-29-25-10-2-3-11-27(25)32(28)24-16-21-8-5-9-22(17-24)31(21)23-14-19-6-4-7-20(13-19)15-23/h2-3,10-12,19-24H,4-9,13-17H2,1H3/t19-,20+,21-,22+,23+,24+
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4.20n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172437
PNG
(US9090618, ZA60 | US9598411, Ref. No. ZA60)
Show SMILES C(c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)c1cnccn1
Show InChI InChI=1S/C30H39N5/c1-2-7-22-14-21(6-1)15-26(16-22)34-24-8-5-9-25(34)19-27(18-24)35-29-11-4-3-10-28(29)33-30(35)17-23-20-31-12-13-32-23/h3-4,10-13,20-22,24-27H,1-2,5-9,14-19H2/t21-,22+,24-,25+,26-,27+
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4.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172380
PNG
(US9090618, H4d | US9598411, Ref. No. H4d)
Show SMILES OC(=O)CN1CC(C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H42N4O2/c35-29(36)19-32-17-22(18-32)30-31-27-10-3-4-11-28(27)34(30)26-15-23-8-5-9-24(16-26)33(23)25-13-20-6-1-2-7-21(12-20)14-25/h3-4,10-11,20-26H,1-2,5-9,12-19H2,(H,35,36)/t20-,21+,23-,24+,25-,26+
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4.73n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172446
PNG
(US9090618, ZA69 | US9598411, Ref. No. ZA69)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1cc[nH]n1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-14-19(6-1)15-23(16-20)32-21-8-5-9-22(32)18-24(17-21)33-27-11-4-3-10-25(27)30-28(33)26-12-13-29-31-26/h3-4,10-13,19-24H,1-2,5-9,14-18H2,(H,29,31)/t19-,20+,21-,22+,23-,24+
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4.90n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172416
PNG
(US9090618, ZA39 | US9598411, Ref. No. ZA39)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1nnn[nH]1
Show InChI InChI=1S/C26H35N7/c1-2-7-18-12-17(6-1)13-21(14-18)32-19-8-5-9-20(32)16-22(15-19)33-24-11-4-3-10-23(24)27-26(33)25-28-30-31-29-25/h3-4,10-11,17-22H,1-2,5-9,12-16H2,(H,28,29,30,31)/t17-,18+,19-,20+,21-,22+
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5.10n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172432
PNG
(US9090618, ZA55 | US9598411, Ref. No. ZA55)
Show SMILES C([C@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m0/s1
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5.40n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172445
PNG
(US9090618, ZA68 | US9598411, Ref. No. ZA68)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1c[nH]cn1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-12-19(6-1)13-23(14-20)32-21-8-5-9-22(32)16-24(15-21)33-27-11-4-3-10-25(27)31-28(33)26-17-29-18-30-26/h3-4,10-11,17-24H,1-2,5-9,12-16H2,(H,29,30)/t19-,20+,21-,22+,23-,24+
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6n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172427
PNG
(US9090618, ZA50 | US9598411, Ref. No. ZA50)
Show SMILES CS(=O)(=O)NCCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-14-16-36-15-13-26(23-36)20-33-35-31-11-4-5-12-32(31)38(33)30-21-27-9-6-10-28(22-30)37(27)29-18-24-7-2-3-8-25(17-24)19-29/h4-5,11-12,24-30,34H,2-3,6-10,13-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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6.14n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172447
PNG
(US9090618, ZA70 | US9598411, Ref. No. ZA70)
Show SMILES Cn1cc(Cl)c(n1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C29H38ClN5/c1-33-18-25(30)28(32-33)29-31-26-11-4-5-12-27(26)35(29)24-16-21-9-6-10-22(17-24)34(21)23-14-19-7-2-3-8-20(13-19)15-23/h4-5,11-12,18-24H,2-3,6-10,13-17H2,1H3/t19-,20+,21-,22+,23-,24+
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6.70n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172443
PNG
(US9090618, ZA66 | US9598411, Ref. No. ZA66)
Show SMILES C1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c(nc2ccccc12)-c1ccno1
Show InChI InChI=1S/C27H34N4O/c1-2-10-25-24(9-1)29-27(26-11-12-28-32-26)31(25)23-16-20-7-4-8-21(17-23)30(20)22-14-18-5-3-6-19(13-18)15-22/h1-2,9-12,18-23H,3-8,13-17H2/t18-,19+,20-,21+,22+,23+
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7.10n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172434
PNG
(US9090618, ZA57 | US9598411, Ref. No. ZA57)
Show SMILES Cn1ccnc1CN1CCOC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C35H50N6O/c1-38-14-13-36-35(38)23-39-15-16-42-24-31(39)22-34-37-32-11-4-5-12-33(32)41(34)30-20-27-9-6-10-28(21-30)40(27)29-18-25-7-2-3-8-26(17-25)19-29/h4-5,11-14,25-31H,2-3,6-10,15-24H2,1H3/t25-,26+,27-,28+,29-,30+,31-/m1/s1
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8.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172381
PNG
(US9090618, H6d | US9598411, Ref. No. H6d)
Show SMILES OC(=O)CCN1CC(C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)12-13-33-19-23(20-33)31-32-28-10-3-4-11-29(28)35(31)27-17-24-8-5-9-25(18-27)34(24)26-15-21-6-1-2-7-22(14-21)16-26/h3-4,10-11,21-27H,1-2,5-9,12-20H2,(H,36,37)/t21-,22+,24-,25+,26-,27+
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8.90n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172384
PNG
(US9090618, H30b(ii) | US9598411, Ref. No. H30b(ii))
Show SMILES OC(=O)CN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m1/s1
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9n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172408
PNG
(US9090618, ZA27 | US9598411, Ref. No. ZA27)
Show SMILES NC(=O)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C21H31N5O/c22-20(27)24-21-23-18-10-6-7-11-19(18)26(21)17-12-14-25(15-13-17)16-8-4-2-1-3-5-9-16/h6-7,10-11,16-17H,1-5,8-9,12-15H2,(H3,22,23,24,27)
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10n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172390
PNG
(US9090618, H56b(ii) | US9598411, Ref. No. H56b(ii))
Show SMILES OC(=O)CN1CCCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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11n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172426
PNG
(US9090618, ZA49 | US9598411, Ref. No. ZA49)
Show SMILES CS(=O)(=O)NCCN1CCC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C34H53N5O2S/c1-42(40,41)35-15-17-37-16-7-10-27(24-37)21-34-36-32-13-4-5-14-33(32)39(34)31-22-28-11-6-12-29(23-31)38(28)30-19-25-8-2-3-9-26(18-25)20-30/h4-5,13-14,25-31,35H,2-3,6-12,15-24H2,1H3/t25-,26+,27-,28-,29+,30-,31+/m0/s1
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11.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172412
PNG
(US9090618, ZA33 | US9598411, Ref. No. ZA33)
Show SMILES OC(=O)CNc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2C1CCCCCCCCC1
Show InChI InChI=1S/C27H40N4O2/c32-26(33)19-28-27-29-24-15-8-9-16-25(24)31(27)23-17-21-13-10-14-22(18-23)30(21)20-11-6-4-2-1-3-5-7-12-20/h8-9,15-16,20-23H,1-7,10-14,17-19H2,(H,28,29)(H,32,33)/t21-,22+,23?
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13n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172397
PNG
(US9090618, ZA09 | US9598411, Ref. No. ZA09)
Show SMILES OC(=O)CN1CCC(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)CC1
Show InChI InChI=1S/C33H48N4O2/c38-33(39)22-35-14-12-23(13-15-35)19-32-34-30-10-3-4-11-31(30)37(32)29-20-26-8-5-9-27(21-29)36(26)28-17-24-6-1-2-7-25(16-24)18-28/h3-4,10-11,23-29H,1-2,5-9,12-22H2,(H,38,39)/t24-,25+,26-,27+,28-,29+
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14.2n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172420
PNG
(US9090618, ZA43 | US9598411, Ref. No. ZA43)
Show SMILES CS(=O)(=O)NCCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-15-17-36-16-7-12-26(36)23-33-35-31-13-4-5-14-32(31)38(33)30-21-27-10-6-11-28(22-30)37(27)29-19-24-8-2-3-9-25(18-24)20-29/h4-5,13-14,24-30,34H,2-3,6-12,15-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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14.9n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172393
PNG
(US9090618, H62d(ii) | US9598411, Ref. No. H62d(ii))
Show SMILES NC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H47N5O/c33-31(38)21-35-14-6-9-24(20-35)32-34-29-12-3-4-13-30(29)37(32)28-18-25-10-5-11-26(19-28)36(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H2,33,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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15.7n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172429
PNG
(US9090618, ZA52 | US9598411, Ref. No. ZA52)
Show SMILES CCN(CC)C(=O)CN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C36H55N5O/c1-3-39(4-2)36(42)25-38-17-16-28(24-38)21-35-37-33-14-7-8-15-34(33)41(35)32-22-29-12-9-13-30(23-32)40(29)31-19-26-10-5-6-11-27(18-26)20-31/h7-8,14-15,26-32H,3-6,9-13,16-25H2,1-2H3/t26-,27+,28-,29-,30+,31-,32+/m0/s1
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15.8n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172390
PNG
(US9090618, H56b(ii) | US9598411, Ref. No. H56b(ii))
Show SMILES OC(=O)CN1CCCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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16.3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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17n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172407
PNG
(US9090618, ZA26 | US9598411, Ref. No. ZA26)
Show SMILES CCOC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C23H35N5O/c1-2-29-22(24)26-23-25-20-12-8-9-13-21(20)28(23)19-14-16-27(17-15-19)18-10-6-4-3-5-7-11-18/h8-9,12-13,18-19H,2-7,10-11,14-17H2,1H3,(H2,24,25,26)
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17.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172383
PNG
(US9090618, H30b(i) | US9598411, Ref. No. H30b(i))
Show SMILES OC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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18.2n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172385
PNG
(US9090618, H30d(ii) | US9598411, Ref. No. H30d(ii))
Show SMILES OC(=O)CN1CC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-13-12-23(19-33)31-32-28-10-3-4-11-29(28)35(31)27-17-24-8-5-9-25(18-27)34(24)26-15-21-6-1-2-7-22(14-21)16-26/h3-4,10-11,21-27H,1-2,5-9,12-20H2,(H,36,37)/t21-,22+,23-,24-,25+,26-,27+/m0/s1
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18.6n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172388
PNG
(US9090618, H36b(i) | US9598411, Ref. No. H36b(i))
Show SMILES NC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H45N5O/c32-30(37)20-34-14-6-13-29(34)31-33-27-11-3-4-12-28(27)36(31)26-18-23-9-5-10-24(19-26)35(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H2,32,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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19n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172435
PNG
(US9090618, ZA58 | US9598411, Ref. No. ZA58)
Show SMILES OC(=O)CCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)14-16-35-15-6-11-25(35)22-32-34-30-12-3-4-13-31(30)37(32)29-20-26-9-5-10-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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19.9n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172448
PNG
(US9090618, ZA71 | US9598411, Ref. No. ZA71)
Show SMILES O=c1cc([nH]c(=O)[nH]1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C29H37N5O2/c35-27-17-25(31-29(36)32-27)28-30-24-10-3-4-11-26(24)34(28)23-15-20-8-5-9-21(16-23)33(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,17-23H,1-2,5-9,12-16H2,(H2,31,32,35,36)/t18-,19+,20-,21+,22-,23+
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20.8n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172441
PNG
(US9090618, ZA64 | US9598411, Ref. No. ZA64)
Show SMILES C1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c(nc2ccccc12)-c1cnccn1
Show InChI InChI=1S/C28H35N5/c1-2-10-27-25(9-1)31-28(26-18-29-11-12-30-26)33(27)24-16-21-7-4-8-22(17-24)32(21)23-14-19-5-3-6-20(13-19)15-23/h1-2,9-12,18-24H,3-8,13-17H2/t19-,20+,21-,22+,23+,24+
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21.6n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172394
PNG
(US9090618, O85d | US9598411, Ref. No. O85d)
Show SMILES OC(=O)CN1\C(N([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c2ccccc12)=C1\CCCN(CC(O)=O)C1
Show InChI InChI=1S/C34H48N4O4/c39-32(40)21-35-14-6-9-25(20-35)34-36(22-33(41)42)30-12-3-4-13-31(30)38(34)29-18-26-10-5-11-27(19-29)37(26)28-16-23-7-1-2-8-24(15-23)17-28/h3-4,12-13,23-24,26-29H,1-2,5-11,14-22H2,(H,39,40)(H,41,42)/b34-25+/t23-,24+,26-,27+,28-,29+
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21.7n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172409
PNG
(US9090618, ZA28 | US9598411, Ref. No. ZA28)
Show SMILES CONC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C22H34N6O/c1-29-26-21(23)25-22-24-19-11-7-8-12-20(19)28(22)18-13-15-27(16-14-18)17-9-5-3-2-4-6-10-17/h7-8,11-12,17-18H,2-6,9-10,13-16H2,1H3,(H3,23,24,25,26)
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22.4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172398
PNG
(US9090618, ZA10 | US9598411, Ref. No. ZA10)
Show SMILES OC(=O)CCN1CCC(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)CC1
Show InChI InChI=1S/C34H50N4O2/c39-34(40)14-17-36-15-12-24(13-16-36)21-33-35-31-10-3-4-11-32(31)38(33)30-22-27-8-5-9-28(23-30)37(27)29-19-25-6-1-2-7-26(18-25)20-29/h3-4,10-11,24-30H,1-2,5-9,12-23H2,(H,39,40)/t25-,26+,27-,28+,29-,30+
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23.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172409
PNG
(US9090618, ZA28 | US9598411, Ref. No. ZA28)
Show SMILES CONC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C22H34N6O/c1-29-26-21(23)25-22-24-19-11-7-8-12-20(19)28(22)18-13-15-27(16-14-18)17-9-5-3-2-4-6-10-17/h7-8,11-12,17-18H,2-6,9-10,13-16H2,1H3,(H3,23,24,25,26)
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26.2n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM302115
PNG
(US9598411, Ref. No. ZA23)
Show SMILES CC(=O)C1CCN(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)CC1
Show InChI InChI=1S/C32H46N4O/c1-22(37)25-12-14-34(15-13-25)21-32-33-30-10-2-3-11-31(30)36(32)29-19-26-8-5-9-27(20-29)35(26)28-17-23-6-4-7-24(16-23)18-28/h2-3,10-11,23-29H,4-9,12-21H2,1H3/t23-,24+,26-,27+,28+,29+
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27.7n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172436
PNG
(US9090618, ZA59 | US9598411, Ref. No. ZA59)
Show SMILES OC(=O)CN1CCCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)22-35-15-6-5-10-25(35)21-32-34-30-13-3-4-14-31(30)37(32)29-19-26-11-7-12-27(20-29)36(26)28-17-23-8-1-2-9-24(16-23)18-28/h3-4,13-14,23-29H,1-2,5-12,15-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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29.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172429
PNG
(US9090618, ZA52 | US9598411, Ref. No. ZA52)
Show SMILES CCN(CC)C(=O)CN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C36H55N5O/c1-3-39(4-2)36(42)25-38-17-16-28(24-38)21-35-37-33-14-7-8-15-34(33)41(35)32-22-29-12-9-13-30(23-32)40(29)31-19-26-10-5-6-11-27(18-26)20-31/h7-8,14-15,26-32H,3-6,9-13,16-25H2,1-2H3/t26-,27+,28-,29-,30+,31-,32+/m0/s1
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30.4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172432
PNG
(US9090618, ZA55 | US9598411, Ref. No. ZA55)
Show SMILES C([C@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m0/s1
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31.3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172408
PNG
(US9090618, ZA27 | US9598411, Ref. No. ZA27)
Show SMILES NC(=O)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C21H31N5O/c22-20(27)24-21-23-18-10-6-7-11-19(18)26(21)17-12-14-25(15-13-17)16-8-4-2-1-3-5-9-16/h6-7,10-11,16-17H,1-5,8-9,12-15H2,(H3,22,23,24,27)
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33.7n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172425
PNG
(US9090618, ZA48 | US9598411, Ref. No. ZA48)
Show SMILES OC(=O)CCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H48N4O2/c38-33(39)13-15-35-14-12-25(22-35)19-32-34-30-10-3-4-11-31(30)37(32)29-20-26-8-5-9-27(21-29)36(26)28-17-23-6-1-2-7-24(16-23)18-28/h3-4,10-11,23-29H,1-2,5-9,12-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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36n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172408
PNG
(US9090618, ZA27 | US9598411, Ref. No. ZA27)
Show SMILES NC(=O)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C21H31N5O/c22-20(27)24-21-23-18-10-6-7-11-19(18)26(21)17-12-14-25(15-13-17)16-8-4-2-1-3-5-9-16/h6-7,10-11,16-17H,1-5,8-9,12-15H2,(H3,22,23,24,27)
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36.7n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172410
PNG
(US9090618, ZA29 | US9598411, Ref. No. ZA29)
Show SMILES COC(=O)\N=c1/n(CC(N)=O)c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C24H35N5O3/c1-32-24(31)26-23-28(17-22(25)30)20-11-7-8-12-21(20)29(23)19-13-15-27(16-14-19)18-9-5-3-2-4-6-10-18/h7-8,11-12,18-19H,2-6,9-10,13-17H2,1H3,(H2,25,30)/b26-23+
PDB

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37.1n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172377
PNG
(US9090618, E30c(ii) | US9598411, Ref. No. E30c(ii))
Show SMILES OC(=O)CN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2C1CCCCCCCCC1
Show InChI InChI=1S/C31H46N4O2/c36-30(37)22-33-19-11-18-29(33)31-32-27-16-8-9-17-28(27)35(31)26-20-24-14-10-15-25(21-26)34(24)23-12-6-4-2-1-3-5-7-13-23/h8-9,16-17,23-26,29H,1-7,10-15,18-22H2,(H,36,37)/t24-,25+,26+,29-/m1/s1
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37.9n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172442
PNG
(US9090618, ZA65 | US9598411, Ref. No. ZA65)
Show SMILES Cc1nc(C)c(s1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C29H38N4S/c1-18-28(34-19(2)30-18)29-31-26-11-3-4-12-27(26)33(29)25-16-22-9-6-10-23(17-25)32(22)24-14-20-7-5-8-21(13-20)15-24/h3-4,11-12,20-25H,5-10,13-17H2,1-2H3/t20-,21+,22-,23+,24+,25+
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40n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172394
PNG
(US9090618, O85d | US9598411, Ref. No. O85d)
Show SMILES OC(=O)CN1\C(N([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c2ccccc12)=C1\CCCN(CC(O)=O)C1
Show InChI InChI=1S/C34H48N4O4/c39-32(40)21-35-14-6-9-25(20-35)34-36(22-33(41)42)30-12-3-4-13-31(30)38(34)29-18-26-10-5-11-27(19-29)37(26)28-16-23-7-1-2-8-24(15-23)17-28/h3-4,12-13,23-24,26-29H,1-2,5-11,14-22H2,(H,39,40)(H,41,42)/b34-25+/t23-,24+,26-,27+,28-,29+
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41.3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172395
PNG
(US9090618, ZA07 | US9598411, Ref. No. ZA07)
Show SMILES OC(=O)CN1CCC(CC1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-14-12-24(13-15-34)32-33-29-10-3-4-11-30(29)36(32)28-19-25-8-5-9-26(20-28)35(25)27-17-22-6-1-2-7-23(16-22)18-27/h3-4,10-11,22-28H,1-2,5-9,12-21H2,(H,37,38)/t22-,23+,25-,26+,27-,28+
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US Patent
42.7n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172391
PNG
(US9090618, H56d(ii) | US9598411, Ref. No. H56d(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-14-6-9-24(20-34)32-33-29-12-3-4-13-30(29)36(32)28-18-25-10-5-11-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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43.4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172420
PNG
(US9090618, ZA43 | US9598411, Ref. No. ZA43)
Show SMILES CS(=O)(=O)NCCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-15-17-36-16-7-12-26(36)23-33-35-31-13-4-5-14-32(31)38(33)30-21-27-10-6-11-28(22-30)37(27)29-19-24-8-2-3-9-25(18-24)20-29/h4-5,13-14,24-30,34H,2-3,6-12,15-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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43.7n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172389
PNG
(US9090618, H56b(i) | US9598411, Ref. No. H56b(i))
Show SMILES OC(=O)CN1CCCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m0/s1
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45.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172439
PNG
(US9090618, ZA62 | US9598411, Ref. No. ZA62)
Show SMILES C(c1nnn[nH]1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C27H37N7/c1-2-7-19-12-18(6-1)13-22(14-19)33-20-8-5-9-21(33)16-23(15-20)34-25-11-4-3-10-24(25)28-27(34)17-26-29-31-32-30-26/h3-4,10-11,18-23H,1-2,5-9,12-17H2,(H,29,30,31,32)/t18-,19+,20-,21+,22-,23+
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47.2n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172428
PNG
(US9090618, ZA51 | US9598411, Ref. No. ZA51)
Show SMILES CCN(CC)C(=O)CN1CCC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C37H57N5O/c1-3-40(4-2)37(43)26-39-18-10-13-29(25-39)22-36-38-34-16-7-8-17-35(34)42(36)33-23-30-14-9-15-31(24-33)41(30)32-20-27-11-5-6-12-28(19-27)21-32/h7-8,16-17,27-33H,3-6,9-15,18-26H2,1-2H3/t27-,28+,29-,30-,31+,32-,33+/m0/s1
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47.9n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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49n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172433
PNG
(US9090618, ZA56 | US9598411, Ref. No. ZA56)
Show SMILES C([C@@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m1/s1
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50.1n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172446
PNG
(US9090618, ZA69 | US9598411, Ref. No. ZA69)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1cc[nH]n1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-14-19(6-1)15-23(16-20)32-21-8-5-9-22(32)18-24(17-21)33-27-11-4-3-10-25(27)30-28(33)26-12-13-29-31-26/h3-4,10-13,19-24H,1-2,5-9,14-18H2,(H,29,31)/t19-,20+,21-,22+,23-,24+
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51n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172390
PNG
(US9090618, H56b(ii) | US9598411, Ref. No. H56b(ii))
Show SMILES OC(=O)CN1CCCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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55n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172427
PNG
(US9090618, ZA50 | US9598411, Ref. No. ZA50)
Show SMILES CS(=O)(=O)NCCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-14-16-36-15-13-26(23-36)20-33-35-31-11-4-5-12-32(31)38(33)30-21-27-9-6-10-28(22-30)37(27)29-18-24-7-2-3-8-25(17-24)19-29/h4-5,11-12,24-30,34H,2-3,6-10,13-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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58.3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172407
PNG
(US9090618, ZA26 | US9598411, Ref. No. ZA26)
Show SMILES CCOC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C23H35N5O/c1-2-29-22(24)26-23-25-20-12-8-9-13-21(20)28(23)19-14-16-27(17-15-19)18-10-6-4-3-5-7-11-18/h8-9,12-13,18-19H,2-7,10-11,14-17H2,1H3,(H2,24,25,26)
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59n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172412
PNG
(US9090618, ZA33 | US9598411, Ref. No. ZA33)
Show SMILES OC(=O)CNc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2C1CCCCCCCCC1
Show InChI InChI=1S/C27H40N4O2/c32-26(33)19-28-27-29-24-15-8-9-16-25(24)31(27)23-17-21-13-10-14-22(18-23)30(21)20-11-6-4-2-1-3-5-7-12-20/h8-9,15-16,20-23H,1-7,10-14,17-19H2,(H,28,29)(H,32,33)/t21-,22+,23?
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59.1n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172411
PNG
(US9090618, ZA31 | US9598411, Ref. No. ZA31)
Show SMILES OC(=O)CNc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C26H36N4O2/c31-25(32)16-27-26-28-23-9-1-2-10-24(23)30(26)22-14-19-7-4-8-20(15-22)29(19)21-12-17-5-3-6-18(11-17)13-21/h1-2,9-10,17-22H,3-8,11-16H2,(H,27,28)(H,31,32)/t17-,18+,19-,20+,21+,22?
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65n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172384
PNG
(US9090618, H30b(ii) | US9598411, Ref. No. H30b(ii))
Show SMILES OC(=O)CN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m1/s1
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65.2n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172406
PNG
(US9090618, ZA25 | US9598411, Ref. No. ZA25)
Show SMILES OC(=O)CN1CCN(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)CC1
Show InChI InChI=1S/C31H45N5O2/c37-31(38)21-34-13-11-33(12-14-34)20-30-32-28-9-1-2-10-29(28)36(30)27-18-24-7-4-8-25(19-27)35(24)26-16-22-5-3-6-23(15-22)17-26/h1-2,9-10,22-27H,3-8,11-21H2,(H,37,38)/t22-,23+,24-,25+,26+,27+
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66n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172394
PNG
(US9090618, O85d | US9598411, Ref. No. O85d)
Show SMILES OC(=O)CN1\C(N([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c2ccccc12)=C1\CCCN(CC(O)=O)C1
Show InChI InChI=1S/C34H48N4O4/c39-32(40)21-35-14-6-9-25(20-35)34-36(22-33(41)42)30-12-3-4-13-31(30)38(34)29-18-26-10-5-11-27(19-29)37(26)28-16-23-7-1-2-8-24(15-23)17-28/h3-4,12-13,23-24,26-29H,1-2,5-11,14-22H2,(H,39,40)(H,41,42)/b34-25+/t23-,24+,26-,27+,28-,29+
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76n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172447
PNG
(US9090618, ZA70 | US9598411, Ref. No. ZA70)
Show SMILES Cn1cc(Cl)c(n1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C29H38ClN5/c1-33-18-25(30)28(32-33)29-31-26-11-4-5-12-27(26)35(29)24-16-21-9-6-10-22(17-24)34(21)23-14-19-7-2-3-8-20(13-19)15-23/h4-5,11-12,18-24H,2-3,6-10,13-17H2,1H3/t19-,20+,21-,22+,23-,24+
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79n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172387
PNG
(US9090618, H32d(ii) | US9598411, Ref. No. H32d(ii))
Show SMILES OC(=O)CCN1CC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)13-15-34-14-12-24(21-34)32-33-29-10-3-4-11-30(29)36(32)28-19-25-8-5-9-26(20-28)35(25)27-17-22-6-1-2-7-23(16-22)18-27/h3-4,10-11,22-28H,1-2,5-9,12-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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86n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172392
PNG
(US9090618, H58d(ii) | US9598411, Ref. No. H58d(ii))
Show SMILES OC(=O)CCN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-32(39)14-16-35-15-6-9-25(22-35)33-34-30-12-3-4-13-31(30)37(33)29-20-26-10-5-11-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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86n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172445
PNG
(US9090618, ZA68 | US9598411, Ref. No. ZA68)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1c[nH]cn1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-12-19(6-1)13-23(14-20)32-21-8-5-9-22(32)16-24(15-21)33-27-11-4-3-10-25(27)31-28(33)26-17-29-18-30-26/h3-4,10-11,17-24H,1-2,5-9,12-16H2,(H,29,30)/t19-,20+,21-,22+,23-,24+
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89.6n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172396
PNG
(US9090618, ZA08 | US9598411, Ref. No. ZA08)
Show SMILES OC(=O)CCN1CCC(CC1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-32(39)14-17-35-15-12-25(13-16-35)33-34-30-10-3-4-11-31(30)37(33)29-21-26-8-5-9-27(22-29)36(26)28-19-23-6-1-2-7-24(18-23)20-28/h3-4,10-11,23-29H,1-2,5-9,12-22H2,(H,38,39)/t23-,24+,26-,27+,28-,29+
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92n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172386
PNG
(US9090618, H32b(ii) | US9598411, Ref. No. H32b(ii))
Show SMILES OC(=O)CCN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)14-16-34-15-6-13-30(34)32-33-28-11-3-4-12-29(28)36(32)27-20-24-9-5-10-25(21-27)35(24)26-18-22-7-1-2-8-23(17-22)19-26/h3-4,11-12,22-27,30H,1-2,5-10,13-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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96.9n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM302124
PNG
(US9598411, Ref. No. ZA37)
Show SMILES OC(=O)CO\N=C\c1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C27H36N4O3/c32-27(33)17-34-28-16-26-29-24-9-1-2-10-25(24)31(26)23-14-20-7-4-8-21(15-23)30(20)22-12-18-5-3-6-19(11-18)13-22/h1-2,9-10,16,18-23H,3-8,11-15,17H2,(H,32,33)/b28-16+/t18-,19+,20-,21+,22+,23?
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102n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172383
PNG
(US9090618, H30b(i) | US9598411, Ref. No. H30b(i))
Show SMILES OC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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108n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172389
PNG
(US9090618, H56b(i) | US9598411, Ref. No. H56b(i))
Show SMILES OC(=O)CN1CCCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m0/s1
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108n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172437
PNG
(US9090618, ZA60 | US9598411, Ref. No. ZA60)
Show SMILES C(c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)c1cnccn1
Show InChI InChI=1S/C30H39N5/c1-2-7-22-14-21(6-1)15-26(16-22)34-24-8-5-9-25(34)19-27(18-24)35-29-11-4-3-10-28(29)33-30(35)17-23-20-31-12-13-32-23/h3-4,10-13,20-22,24-27H,1-2,5-9,14-19H2/t21-,22+,24-,25+,26-,27+
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115n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172424
PNG
(US9090618, ZA47 | US9598411, Ref. No. ZA47)
Show SMILES OC(=O)CCN1CCC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C34H50N4O2/c39-34(40)14-16-36-15-6-9-26(23-36)20-33-35-31-12-3-4-13-32(31)38(33)30-21-27-10-5-11-28(22-30)37(27)29-18-24-7-1-2-8-25(17-24)19-29/h3-4,12-13,24-30H,1-2,5-11,14-23H2,(H,39,40)/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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117n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172400
PNG
(US9090618, ZA12 | US9598411, Ref. No. ZA12)
Show SMILES COCCOCCOCCN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C36H56N4O3/c1-41-17-18-43-20-19-42-16-15-38-14-6-9-29(26-38)36-37-34-12-2-3-13-35(34)40(36)33-24-30-10-5-11-31(25-33)39(30)32-22-27-7-4-8-28(21-27)23-32/h2-3,12-13,27-33H,4-11,14-26H2,1H3/t27-,28+,29-,30-,31+,32+,33+/m0/s1
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117n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172422
PNG
(US9090618, ZA45 | US9598411, Ref. No. ZA45)
Show SMILES OC(=O)CN1CCC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H48N4O2/c38-33(39)22-35-14-6-9-25(21-35)18-32-34-30-12-3-4-13-31(30)37(32)29-19-26-10-5-11-27(20-29)36(26)28-16-23-7-1-2-8-24(15-23)17-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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120n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172388
PNG
(US9090618, H36b(i) | US9598411, Ref. No. H36b(i))
Show SMILES NC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H45N5O/c32-30(37)20-34-14-6-13-29(34)31-33-27-11-3-4-12-28(27)36(31)26-18-23-9-5-10-24(19-26)35(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H2,32,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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123n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172438
PNG
(US9090618, ZA61 | US9598411, Ref. No. ZA61)
Show SMILES Cc1nnc(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)[nH]1
Show InChI InChI=1S/C29H40N6/c1-19-30-28(33-32-19)18-29-31-26-11-4-5-12-27(26)35(29)25-16-22-9-6-10-23(17-25)34(22)24-14-20-7-2-3-8-21(13-20)15-24/h4-5,11-12,20-25H,2-3,6-10,13-18H2,1H3,(H,30,32,33)/t20-,21+,22-,23+,24-,25+
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130n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172383
PNG
(US9090618, H30b(i) | US9598411, Ref. No. H30b(i))
Show SMILES OC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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150n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172421
PNG
(US9090618, ZA44 | US9598411, Ref. No. ZA44)
Show SMILES CCN(CC)C(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C36H55N5O/c1-3-38(4-2)36(42)25-39-18-10-15-28(39)24-35-37-33-16-7-8-17-34(33)41(35)32-22-29-13-9-14-30(23-32)40(29)31-20-26-11-5-6-12-27(19-26)21-31/h7-8,16-17,26-32H,3-6,9-15,18-25H2,1-2H3/t26-,27+,28-,29-,30+,31-,32+/m0/s1
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167n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172436
PNG
(US9090618, ZA59 | US9598411, Ref. No. ZA59)
Show SMILES OC(=O)CN1CCCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)22-35-15-6-5-10-25(35)21-32-34-30-13-3-4-14-31(30)37(32)29-19-26-11-7-12-27(20-29)36(26)28-17-23-8-1-2-9-24(16-23)18-28/h3-4,13-14,23-29H,1-2,5-12,15-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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169n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172399
PNG
(US9090618, ZA11 | US9598411, Ref. No. ZA11)
Show SMILES COCCOCCOCCN1CCC[C@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C36H56N4O3/c1-41-17-18-43-20-19-42-16-15-38-14-6-9-29(26-38)36-37-34-12-2-3-13-35(34)40(36)33-24-30-10-5-11-31(25-33)39(30)32-22-27-7-4-8-28(21-27)23-32/h2-3,12-13,27-33H,4-11,14-26H2,1H3/t27-,28+,29-,30-,31+,32+,33+/m1/s1
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182n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172376
PNG
(US9090618, B56c(ii) | US9598411, Ref. No. B56c(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-13-5-8-23(19-33)31-32-28-11-1-2-12-29(28)35(31)27-17-24-9-4-10-25(18-27)34(24)26-15-21-6-3-7-22(14-21)16-26/h1-2,11-12,21-27H,3-10,13-20H2,(H,36,37)/t21-,22+,23-,24-,25+,26+,27+/m0/s1
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220n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172413
PNG
(US9090618, ZA35 | US9598411, Ref. No. ZA35)
Show SMILES OCc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C25H35N3O/c29-16-25-26-23-9-1-2-10-24(23)28(25)22-14-19-7-4-8-20(15-22)27(19)21-12-17-5-3-6-18(11-17)13-21/h1-2,9-10,17-22,29H,3-8,11-16H2/t17-,18+,19-,20+,21+,22?
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246n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172403
PNG
(US9090618, ZA18 | US9598411, Ref. No. ZA18)
Show SMILES OC(=O)CN1CCN(CC1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C30H43N5O2/c36-29(37)20-32-11-13-33(14-12-32)30-31-27-9-1-2-10-28(27)35(30)26-18-23-7-4-8-24(19-26)34(23)25-16-21-5-3-6-22(15-21)17-25/h1-2,9-10,21-26H,3-8,11-20H2,(H,36,37)/t21-,22+,23-,24+,25+,26+
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251n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172392
PNG
(US9090618, H58d(ii) | US9598411, Ref. No. H58d(ii))
Show SMILES OC(=O)CCN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-32(39)14-16-35-15-6-9-25(22-35)33-34-30-12-3-4-13-31(30)37(33)29-20-26-10-5-11-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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254n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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254n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172412
PNG
(US9090618, ZA33 | US9598411, Ref. No. ZA33)
Show SMILES OC(=O)CNc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2C1CCCCCCCCC1
Show InChI InChI=1S/C27H40N4O2/c32-26(33)19-28-27-29-24-15-8-9-16-25(24)31(27)23-17-21-13-10-14-22(18-23)30(21)20-11-6-4-2-1-3-5-7-12-20/h8-9,15-16,20-23H,1-7,10-14,17-19H2,(H,28,29)(H,32,33)/t21-,22+,23?
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265n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172408
PNG
(US9090618, ZA27 | US9598411, Ref. No. ZA27)
Show SMILES NC(=O)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C21H31N5O/c22-20(27)24-21-23-18-10-6-7-11-19(18)26(21)17-12-14-25(15-13-17)16-8-4-2-1-3-5-9-16/h6-7,10-11,16-17H,1-5,8-9,12-15H2,(H3,22,23,24,27)
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339n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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344n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172376
PNG
(US9090618, B56c(ii) | US9598411, Ref. No. B56c(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-13-5-8-23(19-33)31-32-28-11-1-2-12-29(28)35(31)27-17-24-9-4-10-25(18-27)34(24)26-15-21-6-3-7-22(14-21)16-26/h1-2,11-12,21-27H,3-10,13-20H2,(H,36,37)/t21-,22+,23-,24-,25+,26+,27+/m0/s1
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353n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172394
PNG
(US9090618, O85d | US9598411, Ref. No. O85d)
Show SMILES OC(=O)CN1\C(N([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c2ccccc12)=C1\CCCN(CC(O)=O)C1
Show InChI InChI=1S/C34H48N4O4/c39-32(40)21-35-14-6-9-25(20-35)34-36(22-33(41)42)30-12-3-4-13-31(30)38(34)29-18-26-10-5-11-27(19-29)37(26)28-16-23-7-1-2-8-24(15-23)17-28/h3-4,12-13,23-24,26-29H,1-2,5-11,14-22H2,(H,39,40)(H,41,42)/b34-25+/t23-,24+,26-,27+,28-,29+
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390n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172435
PNG
(US9090618, ZA58 | US9598411, Ref. No. ZA58)
Show SMILES OC(=O)CCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)14-16-35-15-6-11-25(35)22-32-34-30-12-3-4-13-31(30)37(32)29-20-26-9-5-10-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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444n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172406
PNG
(US9090618, ZA25 | US9598411, Ref. No. ZA25)
Show SMILES OC(=O)CN1CCN(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)CC1
Show InChI InChI=1S/C31H45N5O2/c37-31(38)21-34-13-11-33(12-14-34)20-30-32-28-9-1-2-10-29(28)36(30)27-18-24-7-4-8-25(19-27)35(24)26-16-22-5-3-6-23(15-22)17-26/h1-2,9-10,22-27H,3-8,11-21H2,(H,37,38)/t22-,23+,24-,25+,26+,27+
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455n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172401
PNG
(US9090618, ZA14 | US9598411, Ref. No. ZA14)
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c(nc2ccccc12)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C30H42N4O2/c1-19-12-20-14-21(13-19)16-24(15-20)33-22-6-4-7-23(33)18-25(17-22)34-27-9-3-2-8-26(27)31-30(34)32-11-5-10-28(32)29(35)36/h2-3,8-9,19-25,28H,4-7,10-18H2,1H3,(H,35,36)/t19-,20-,21+,22-,23+,24+,25+,28-/m0/s1
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505n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172407
PNG
(US9090618, ZA26 | US9598411, Ref. No. ZA26)
Show SMILES CCOC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C23H35N5O/c1-2-29-22(24)26-23-25-20-12-8-9-13-21(20)28(23)19-14-16-27(17-15-19)18-10-6-4-3-5-7-11-18/h8-9,12-13,18-19H,2-7,10-11,14-17H2,1H3,(H2,24,25,26)
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511n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172445
PNG
(US9090618, ZA68 | US9598411, Ref. No. ZA68)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1c[nH]cn1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-12-19(6-1)13-23(14-20)32-21-8-5-9-22(32)16-24(15-21)33-27-11-4-3-10-25(27)31-28(33)26-17-29-18-30-26/h3-4,10-11,17-24H,1-2,5-9,12-16H2,(H,29,30)/t19-,20+,21-,22+,23-,24+
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520n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172446
PNG
(US9090618, ZA69 | US9598411, Ref. No. ZA69)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1cc[nH]n1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-14-19(6-1)15-23(16-20)32-21-8-5-9-22(32)18-24(17-21)33-27-11-4-3-10-25(27)30-28(33)26-12-13-29-31-26/h3-4,10-13,19-24H,1-2,5-9,14-18H2,(H,29,31)/t19-,20+,21-,22+,23-,24+
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529n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172416
PNG
(US9090618, ZA39 | US9598411, Ref. No. ZA39)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1nnn[nH]1
Show InChI InChI=1S/C26H35N7/c1-2-7-18-12-17(6-1)13-21(14-18)32-19-8-5-9-20(32)16-22(15-19)33-24-11-4-3-10-23(24)27-26(33)25-28-30-31-29-25/h3-4,10-11,17-22H,1-2,5-9,12-16H2,(H,28,29,30,31)/t17-,18+,19-,20+,21-,22+
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566n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172379
PNG
(US9090618, E56c(ii) | US9598411, Ref. No. E56c(ii))
Show SMILES OC(=O)CN1CCCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2C1CCCCCCCCC1
Show InChI InChI=1S/C32H48N4O2/c37-31(38)23-34-20-11-10-19-30(34)32-33-28-17-8-9-18-29(28)36(32)27-21-25-15-12-16-26(22-27)35(25)24-13-6-4-2-1-3-5-7-14-24/h8-9,17-18,24-27,30H,1-7,10-16,19-23H2,(H,37,38)/t25-,26+,27+,30-/m1/s1
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583n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172410
PNG
(US9090618, ZA29 | US9598411, Ref. No. ZA29)
Show SMILES COC(=O)\N=c1/n(CC(N)=O)c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C24H35N5O3/c1-32-24(31)26-23-28(17-22(25)30)20-11-7-8-12-21(20)29(23)19-13-15-27(16-14-19)18-9-5-3-2-4-6-10-18/h7-8,11-12,18-19H,2-6,9-10,13-17H2,1H3,(H2,25,30)/b26-23+
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594n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172425
PNG
(US9090618, ZA48 | US9598411, Ref. No. ZA48)
Show SMILES OC(=O)CCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H48N4O2/c38-33(39)13-15-35-14-12-25(22-35)19-32-34-30-10-3-4-11-31(30)37(32)29-20-26-8-5-9-27(21-29)36(26)28-17-23-6-1-2-7-24(16-23)18-28/h3-4,10-11,23-29H,1-2,5-9,12-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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614n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172378
PNG
(US9090618, E32c(ii) | US9598411, Ref. No. E32c(ii))
Show SMILES OC(=O)CCN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2C1CCCCCCCCC1
Show InChI InChI=1S/C32H48N4O2/c37-31(38)19-21-34-20-11-18-30(34)32-33-28-16-8-9-17-29(28)36(32)27-22-25-14-10-15-26(23-27)35(25)24-12-6-4-2-1-3-5-7-13-24/h8-9,16-17,24-27,30H,1-7,10-15,18-23H2,(H,37,38)/t25-,26+,27+,30-/m1/s1
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690n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172391
PNG
(US9090618, H56d(ii) | US9598411, Ref. No. H56d(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-14-6-9-24(20-34)32-33-29-12-3-4-13-30(29)36(32)28-18-25-10-5-11-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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700n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172415
PNG
(US9090618, ZA38 | US9598411, Ref. No. ZA38)
Show SMILES Cc1noc(C)c1S(=O)(=O)N1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C34H47N5O3S/c1-22-33(23(2)42-36-22)43(40,41)37-16-8-15-32(37)34-35-30-13-5-6-14-31(30)39(34)29-20-26-11-7-12-27(21-29)38(26)28-18-24-9-3-4-10-25(17-24)19-28/h5-6,13-14,24-29,32H,3-4,7-12,15-21H2,1-2H3/t24-,25+,26-,27+,28-,29+,32-/m1/s1
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780n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172398
PNG
(US9090618, ZA10 | US9598411, Ref. No. ZA10)
Show SMILES OC(=O)CCN1CCC(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)CC1
Show InChI InChI=1S/C34H50N4O2/c39-34(40)14-17-36-15-12-24(13-16-36)21-33-35-31-10-3-4-11-32(31)38(33)30-22-27-8-5-9-28(23-30)37(27)29-19-25-6-1-2-7-26(18-25)20-29/h3-4,10-11,24-30H,1-2,5-9,12-23H2,(H,39,40)/t25-,26+,27-,28+,29-,30+
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822n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172386
PNG
(US9090618, H32b(ii) | US9598411, Ref. No. H32b(ii))
Show SMILES OC(=O)CCN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)14-16-34-15-6-13-30(34)32-33-28-11-3-4-12-29(28)36(32)27-20-24-9-5-10-25(21-27)35(24)26-18-22-7-1-2-8-23(17-22)19-26/h3-4,11-12,22-27,30H,1-2,5-10,13-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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828n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172447
PNG
(US9090618, ZA70 | US9598411, Ref. No. ZA70)
Show SMILES Cn1cc(Cl)c(n1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C29H38ClN5/c1-33-18-25(30)28(32-33)29-31-26-11-4-5-12-27(26)35(29)24-16-21-9-6-10-22(17-24)34(21)23-14-19-7-2-3-8-20(13-19)15-23/h4-5,11-12,18-24H,2-3,6-10,13-17H2,1H3/t19-,20+,21-,22+,23-,24+
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952n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172384
PNG
(US9090618, H30b(ii) | US9598411, Ref. No. H30b(ii))
Show SMILES OC(=O)CN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m1/s1
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1.11E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172412
PNG
(US9090618, ZA33 | US9598411, Ref. No. ZA33)
Show SMILES OC(=O)CNc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2C1CCCCCCCCC1
Show InChI InChI=1S/C27H40N4O2/c32-26(33)19-28-27-29-24-15-8-9-16-25(24)31(27)23-17-21-13-10-14-22(18-23)30(21)20-11-6-4-2-1-3-5-7-12-20/h8-9,15-16,20-23H,1-7,10-14,17-19H2,(H,28,29)(H,32,33)/t21-,22+,23?
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1.18E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172404
PNG
(US9090618, ZA20 | US9598411, Ref. No. ZA20)
Show SMILES OC(=O)[C@H]1CCCN1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C29H40N4O2/c34-28(35)27-12-5-13-31(27)29-30-25-10-1-2-11-26(25)33(29)24-17-21-8-4-9-22(18-24)32(21)23-15-19-6-3-7-20(14-19)16-23/h1-2,10-11,19-24,27H,3-9,12-18H2,(H,34,35)/t19-,20+,21-,22+,23+,24+,27-/m1/s1
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1.25E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM302124
PNG
(US9598411, Ref. No. ZA37)
Show SMILES OC(=O)CO\N=C\c1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C27H36N4O3/c32-27(33)17-34-28-16-26-29-24-9-1-2-10-25(24)31(26)23-14-20-7-4-8-21(15-23)30(20)22-12-18-5-3-6-19(11-18)13-22/h1-2,9-10,16,18-23H,3-8,11-15,17H2,(H,32,33)/b28-16+/t18-,19+,20-,21+,22+,23?
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1.50E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM302124
PNG
(US9598411, Ref. No. ZA37)
Show SMILES OC(=O)CO\N=C\c1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C27H36N4O3/c32-27(33)17-34-28-16-26-29-24-9-1-2-10-25(24)31(26)23-14-20-7-4-8-21(15-23)30(20)22-12-18-5-3-6-19(11-18)13-22/h1-2,9-10,16,18-23H,3-8,11-15,17H2,(H,32,33)/b28-16+/t18-,19+,20-,21+,22+,23?
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1.54E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172413
PNG
(US9090618, ZA35 | US9598411, Ref. No. ZA35)
Show SMILES OCc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C25H35N3O/c29-16-25-26-23-9-1-2-10-24(23)28(25)22-14-19-7-4-8-20(15-22)27(19)21-12-17-5-3-6-18(11-17)13-21/h1-2,9-10,17-22,29H,3-8,11-16H2/t17-,18+,19-,20+,21+,22?
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1.58E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172407
PNG
(US9090618, ZA26 | US9598411, Ref. No. ZA26)
Show SMILES CCOC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C23H35N5O/c1-2-29-22(24)26-23-25-20-12-8-9-13-21(20)28(23)19-14-16-27(17-15-19)18-10-6-4-3-5-7-11-18/h8-9,12-13,18-19H,2-7,10-11,14-17H2,1H3,(H2,24,25,26)
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1.62E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172433
PNG
(US9090618, ZA56 | US9598411, Ref. No. ZA56)
Show SMILES C([C@@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m1/s1
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1.67E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172388
PNG
(US9090618, H36b(i) | US9598411, Ref. No. H36b(i))
Show SMILES NC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H45N5O/c32-30(37)20-34-14-6-13-29(34)31-33-27-11-3-4-12-28(27)36(31)26-18-23-9-5-10-24(19-26)35(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H2,32,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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1.67E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172420
PNG
(US9090618, ZA43 | US9598411, Ref. No. ZA43)
Show SMILES CS(=O)(=O)NCCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-15-17-36-16-7-12-26(36)23-33-35-31-13-4-5-14-32(31)38(33)30-21-27-10-6-11-28(22-30)37(27)29-19-24-8-2-3-9-25(18-24)20-29/h4-5,13-14,24-30,34H,2-3,6-12,15-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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1.84E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172427
PNG
(US9090618, ZA50 | US9598411, Ref. No. ZA50)
Show SMILES CS(=O)(=O)NCCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-14-16-36-15-13-26(23-36)20-33-35-31-11-4-5-12-32(31)38(33)30-21-27-9-6-10-28(22-30)37(27)29-18-24-7-2-3-8-25(17-24)19-29/h4-5,11-12,24-30,34H,2-3,6-10,13-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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1.88E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172432
PNG
(US9090618, ZA55 | US9598411, Ref. No. ZA55)
Show SMILES C([C@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m0/s1
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1.91E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172375
PNG
(US9090618, B56c(i) | US9598411, Ref. No. B56c(i))
Show SMILES OC(=O)CN1CCC[C@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-13-5-8-23(19-33)31-32-28-11-1-2-12-29(28)35(31)27-17-24-9-4-10-25(18-27)34(24)26-15-21-6-3-7-22(14-21)16-26/h1-2,11-12,21-27H,3-10,13-20H2,(H,36,37)/t21-,22+,23-,24-,25+,26+,27+/m1/s1
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2.07E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172409
PNG
(US9090618, ZA28 | US9598411, Ref. No. ZA28)
Show SMILES CONC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C22H34N6O/c1-29-26-21(23)25-22-24-19-11-7-8-12-20(19)28(22)18-13-15-27(16-14-18)17-9-5-3-2-4-6-10-17/h7-8,11-12,17-18H,2-6,9-10,13-16H2,1H3,(H3,23,24,25,26)
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2.47E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172410
PNG
(US9090618, ZA29 | US9598411, Ref. No. ZA29)
Show SMILES COC(=O)\N=c1/n(CC(N)=O)c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C24H35N5O3/c1-32-24(31)26-23-28(17-22(25)30)20-11-7-8-12-21(20)29(23)19-13-15-27(16-14-19)18-9-5-3-2-4-6-10-18/h7-8,11-12,18-19H,2-6,9-10,13-17H2,1H3,(H2,25,30)/b26-23+
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2.77E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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2.85E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172436
PNG
(US9090618, ZA59 | US9598411, Ref. No. ZA59)
Show SMILES OC(=O)CN1CCCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)22-35-15-6-5-10-25(35)21-32-34-30-13-3-4-14-31(30)37(32)29-19-26-11-7-12-27(20-29)36(26)28-17-23-8-1-2-9-24(16-23)18-28/h3-4,13-14,23-29H,1-2,5-12,15-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172429
PNG
(US9090618, ZA52 | US9598411, Ref. No. ZA52)
Show SMILES CCN(CC)C(=O)CN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C36H55N5O/c1-3-39(4-2)36(42)25-38-17-16-28(24-38)21-35-37-33-14-7-8-15-34(33)41(35)32-22-29-12-9-13-30(23-32)40(29)31-19-26-10-5-6-11-27(18-26)20-31/h7-8,14-15,26-32H,3-6,9-13,16-25H2,1-2H3/t26-,27+,28-,29-,30+,31-,32+/m0/s1
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3.01E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM172402
PNG
(US9090618, ZA16 | US9598411, Ref. No. ZA16)
Show SMILES OC(=O)[C@@H]1CCCN1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C29H40N4O2/c34-28(35)27-12-5-13-31(27)29-30-25-10-1-2-11-26(25)33(29)24-17-21-8-4-9-22(18-24)32(21)23-15-19-6-3-7-20(14-19)16-23/h1-2,10-11,19-24,27H,3-9,12-18H2,(H,34,35)/t19-,20+,21-,22+,23+,24+,27-/m0/s1
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3.25E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172383
PNG
(US9090618, H30b(i) | US9598411, Ref. No. H30b(i))
Show SMILES OC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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3.56E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM302124
PNG
(US9598411, Ref. No. ZA37)
Show SMILES OC(=O)CO\N=C\c1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C27H36N4O3/c32-27(33)17-34-28-16-26-29-24-9-1-2-10-25(24)31(26)23-14-20-7-4-8-21(15-23)30(20)22-12-18-5-3-6-19(11-18)13-22/h1-2,9-10,16,18-23H,3-8,11-15,17H2,(H,32,33)/b28-16+/t18-,19+,20-,21+,22+,23?
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3.96E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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4.01E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172447
PNG
(US9090618, ZA70 | US9598411, Ref. No. ZA70)
Show SMILES Cn1cc(Cl)c(n1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C29H38ClN5/c1-33-18-25(30)28(32-33)29-31-26-11-4-5-12-27(26)35(29)24-16-21-9-6-10-22(17-24)34(21)23-14-19-7-2-3-8-20(13-19)15-23/h4-5,11-12,18-24H,2-3,6-10,13-17H2,1H3/t19-,20+,21-,22+,23-,24+
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4.17E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172435
PNG
(US9090618, ZA58 | US9598411, Ref. No. ZA58)
Show SMILES OC(=O)CCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)14-16-35-15-6-11-25(35)22-32-34-30-12-3-4-13-31(30)37(32)29-20-26-9-5-10-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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4.34E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172425
PNG
(US9090618, ZA48 | US9598411, Ref. No. ZA48)
Show SMILES OC(=O)CCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H48N4O2/c38-33(39)13-15-35-14-12-25(22-35)19-32-34-30-10-3-4-11-31(30)37(32)29-20-26-8-5-9-27(21-29)36(26)28-17-23-6-1-2-7-24(16-23)18-28/h3-4,10-11,23-29H,1-2,5-9,12-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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4.50E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172389
PNG
(US9090618, H56b(i) | US9598411, Ref. No. H56b(i))
Show SMILES OC(=O)CN1CCCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m0/s1
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4.64E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172384
PNG
(US9090618, H30b(ii) | US9598411, Ref. No. H30b(ii))
Show SMILES OC(=O)CN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-14-6-13-29(33)31-32-27-11-3-4-12-28(27)35(31)26-18-23-9-5-10-24(19-26)34(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H,36,37)/t21-,22+,23-,24+,25-,26+,29-/m1/s1
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5.28E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172386
PNG
(US9090618, H32b(ii) | US9598411, Ref. No. H32b(ii))
Show SMILES OC(=O)CCN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)14-16-34-15-6-13-30(34)32-33-28-11-3-4-12-29(28)36(32)27-20-24-9-5-10-25(21-27)35(24)26-18-22-7-1-2-8-23(17-22)19-26/h3-4,11-12,22-27,30H,1-2,5-10,13-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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5.54E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172409
PNG
(US9090618, ZA28 | US9598411, Ref. No. ZA28)
Show SMILES CONC(=N)\N=c1/[nH]c2ccccc2n1C1CCN(CC1)C1CCCCCCC1
Show InChI InChI=1S/C22H34N6O/c1-29-26-21(23)25-22-24-19-11-7-8-12-20(19)28(22)18-13-15-27(16-14-18)17-9-5-3-2-4-6-10-17/h7-8,11-12,17-18H,2-6,9-10,13-16H2,1H3,(H3,23,24,25,26)
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5.66E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172446
PNG
(US9090618, ZA69 | US9598411, Ref. No. ZA69)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1cc[nH]n1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-14-19(6-1)15-23(16-20)32-21-8-5-9-22(32)18-24(17-21)33-27-11-4-3-10-25(27)30-28(33)26-12-13-29-31-26/h3-4,10-13,19-24H,1-2,5-9,14-18H2,(H,29,31)/t19-,20+,21-,22+,23-,24+
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6.16E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172389
PNG
(US9090618, H56b(i) | US9598411, Ref. No. H56b(i))
Show SMILES OC(=O)CN1CCCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m0/s1
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6.79E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors kappa


(Homo sapiens (human))
BDBM172406
PNG
(US9090618, ZA25 | US9598411, Ref. No. ZA25)
Show SMILES OC(=O)CN1CCN(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)CC1
Show InChI InChI=1S/C31H45N5O2/c37-31(38)21-34-13-11-33(12-14-34)20-30-32-28-9-1-2-10-29(28)36(30)27-18-24-7-4-8-25(19-27)35(24)26-16-22-5-3-6-23(15-22)17-26/h1-2,9-10,22-27H,3-8,11-21H2,(H,37,38)/t22-,23+,24-,25+,26+,27+
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6.80E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172391
PNG
(US9090618, H56d(ii) | US9598411, Ref. No. H56d(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-14-6-9-24(20-34)32-33-29-12-3-4-13-30(29)36(32)28-18-25-10-5-11-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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7.45E+3n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172376
PNG
(US9090618, B56c(ii) | US9598411, Ref. No. B56c(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-13-5-8-23(19-33)31-32-28-11-1-2-12-29(28)35(31)27-17-24-9-4-10-25(18-27)34(24)26-15-21-6-3-7-22(14-21)16-26/h1-2,11-12,21-27H,3-10,13-20H2,(H,36,37)/t21-,22+,23-,24-,25+,26+,27+/m0/s1
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2.00E+4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172413
PNG
(US9090618, ZA35 | US9598411, Ref. No. ZA35)
Show SMILES OCc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C25H35N3O/c29-16-25-26-23-9-1-2-10-24(23)28(25)22-14-19-7-4-8-20(15-22)27(19)21-12-17-5-3-6-18(11-17)13-21/h1-2,9-10,17-22,29H,3-8,11-16H2/t17-,18+,19-,20+,21+,22?
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2.00E+4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172392
PNG
(US9090618, H58d(ii) | US9598411, Ref. No. H58d(ii))
Show SMILES OC(=O)CCN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-32(39)14-16-35-15-6-9-25(22-35)33-34-30-12-3-4-13-31(30)37(33)29-20-26-10-5-11-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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2.00E+4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172392
PNG
(US9090618, H58d(ii) | US9598411, Ref. No. H58d(ii))
Show SMILES OC(=O)CCN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-32(39)14-16-35-15-6-9-25(22-35)33-34-30-12-3-4-13-31(30)37(33)29-20-26-10-5-11-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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2.00E+4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172436
PNG
(US9090618, ZA59 | US9598411, Ref. No. ZA59)
Show SMILES OC(=O)CN1CCCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)22-35-15-6-5-10-25(35)21-32-34-30-13-3-4-14-31(30)37(32)29-19-26-11-7-12-27(20-29)36(26)28-17-23-8-1-2-9-24(16-23)18-28/h3-4,13-14,23-29H,1-2,5-12,15-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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2.00E+4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172435
PNG
(US9090618, ZA58 | US9598411, Ref. No. ZA58)
Show SMILES OC(=O)CCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H48N4O2/c38-33(39)14-16-35-15-6-11-25(35)22-32-34-30-12-3-4-13-31(30)37(32)29-20-26-9-5-10-27(21-29)36(26)28-18-23-7-1-2-8-24(17-23)19-28/h3-4,12-13,23-29H,1-2,5-11,14-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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2.00E+4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172445
PNG
(US9090618, ZA68 | US9598411, Ref. No. ZA68)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1c[nH]cn1
Show InChI InChI=1S/C28H37N5/c1-2-7-20-12-19(6-1)13-23(14-20)32-21-8-5-9-22(32)16-24(15-21)33-27-11-4-3-10-25(27)31-28(33)26-17-29-18-30-26/h3-4,10-11,17-24H,1-2,5-9,12-16H2,(H,29,30)/t19-,20+,21-,22+,23-,24+
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172398
PNG
(US9090618, ZA10 | US9598411, Ref. No. ZA10)
Show SMILES OC(=O)CCN1CCC(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)CC1
Show InChI InChI=1S/C34H50N4O2/c39-34(40)14-17-36-15-12-24(13-16-36)21-33-35-31-10-3-4-11-32(31)38(33)30-22-27-8-5-9-28(23-30)37(27)29-19-25-6-1-2-7-26(18-25)20-29/h3-4,10-11,24-30H,1-2,5-9,12-23H2,(H,39,40)/t25-,26+,27-,28+,29-,30+
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Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172433
PNG
(US9090618, ZA56 | US9598411, Ref. No. ZA56)
Show SMILES C([C@@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172376
PNG
(US9090618, B56c(ii) | US9598411, Ref. No. B56c(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1S/C31H44N4O2/c36-30(37)20-33-13-5-8-23(19-33)31-32-28-11-1-2-12-29(28)35(31)27-17-24-9-4-10-25(18-27)34(24)26-15-21-6-3-7-22(14-21)16-26/h1-2,11-12,21-27H,3-10,13-20H2,(H,36,37)/t21-,22+,23-,24-,25+,26+,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172386
PNG
(US9090618, H32b(ii) | US9598411, Ref. No. H32b(ii))
Show SMILES OC(=O)CCN1CCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)14-16-34-15-6-13-30(34)32-33-28-11-3-4-12-29(28)36(32)27-20-24-9-5-10-25(21-27)35(24)26-18-22-7-1-2-8-23(17-22)19-26/h3-4,11-12,22-27,30H,1-2,5-10,13-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172429
PNG
(US9090618, ZA52 | US9598411, Ref. No. ZA52)
Show SMILES CCN(CC)C(=O)CN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C36H55N5O/c1-3-39(4-2)36(42)25-38-17-16-28(24-38)21-35-37-33-14-7-8-15-34(33)41(35)32-22-29-12-9-13-30(23-32)40(29)31-19-26-10-5-6-11-27(18-26)20-31/h7-8,14-15,26-32H,3-6,9-13,16-25H2,1-2H3/t26-,27+,28-,29-,30+,31-,32+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172388
PNG
(US9090618, H36b(i) | US9598411, Ref. No. H36b(i))
Show SMILES NC(=O)CN1CCC[C@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C31H45N5O/c32-30(37)20-34-14-6-13-29(34)31-33-27-11-3-4-12-28(27)36(31)26-18-23-9-5-10-24(19-26)35(23)25-16-21-7-1-2-8-22(15-21)17-25/h3-4,11-12,21-26,29H,1-2,5-10,13-20H2,(H2,32,37)/t21-,22+,23-,24+,25-,26+,29-/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172391
PNG
(US9090618, H56d(ii) | US9598411, Ref. No. H56d(ii))
Show SMILES OC(=O)CN1CCC[C@@H](C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-14-6-9-24(20-34)32-33-29-12-3-4-13-30(29)36(32)28-18-25-10-5-11-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM172406
PNG
(US9090618, ZA25 | US9598411, Ref. No. ZA25)
Show SMILES OC(=O)CN1CCN(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)CC1
Show InChI InChI=1S/C31H45N5O2/c37-31(38)21-34-13-11-33(12-14-34)20-30-32-28-9-1-2-10-29(28)36(30)27-18-24-7-4-8-25(19-27)35(24)26-16-22-5-3-6-23(15-22)17-26/h1-2,9-10,22-27H,3-8,11-21H2,(H,37,38)/t22-,23+,24-,25+,26+,27+
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Purdue Pharma L.P.

US Patent


Assay Description
κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172425
PNG
(US9090618, ZA48 | US9598411, Ref. No. ZA48)
Show SMILES OC(=O)CCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H48N4O2/c38-33(39)13-15-35-14-12-25(22-35)19-32-34-30-10-3-4-11-31(30)37(32)29-20-26-8-5-9-27(21-29)36(26)28-17-23-6-1-2-7-24(16-23)18-28/h3-4,10-11,23-29H,1-2,5-9,12-22H2,(H,38,39)/t23-,24+,25-,26-,27+,28-,29+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172432
PNG
(US9090618, ZA55 | US9598411, Ref. No. ZA55)
Show SMILES C([C@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172420
PNG
(US9090618, ZA43 | US9598411, Ref. No. ZA43)
Show SMILES CS(=O)(=O)NCCN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-15-17-36-16-7-12-26(36)23-33-35-31-13-4-5-14-32(31)38(33)30-21-27-10-6-11-28(22-30)37(27)29-19-24-8-2-3-9-25(18-24)20-29/h4-5,13-14,24-30,34H,2-3,6-12,15-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172427
PNG
(US9090618, ZA50 | US9598411, Ref. No. ZA50)
Show SMILES CS(=O)(=O)NCCN1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)C1
Show InChI InChI=1S/C33H51N5O2S/c1-41(39,40)34-14-16-36-15-13-26(23-36)20-33-35-31-11-4-5-12-32(31)38(33)30-21-27-9-6-10-28(22-30)37(27)29-18-24-7-2-3-8-25(17-24)19-29/h4-5,11-12,24-30,34H,2-3,6-10,13-23H2,1H3/t24-,25+,26-,27-,28+,29-,30+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172423
PNG
(US9090618, ZA46 | US9090618, ZA54 | US9598411, Ref...)
Show SMILES OC(=O)CN1CCC[C@H]1Cc1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-32(38)21-34-14-6-11-24(34)20-31-33-29-12-3-4-13-30(29)36(31)28-18-25-9-5-10-26(19-28)35(25)27-16-22-7-1-2-8-23(15-22)17-27/h3-4,12-13,22-28H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25-,26+,27-,28+/m0/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172398
PNG
(US9090618, ZA10 | US9598411, Ref. No. ZA10)
Show SMILES OC(=O)CCN1CCC(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)CC1
Show InChI InChI=1S/C34H50N4O2/c39-34(40)14-17-36-15-12-24(13-16-36)21-33-35-31-10-3-4-11-32(31)38(33)30-22-27-8-5-9-28(23-30)37(27)29-19-25-6-1-2-7-26(18-25)20-29/h3-4,10-11,24-30H,1-2,5-9,12-23H2,(H,39,40)/t25-,26+,27-,28+,29-,30+
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
Opioid receptors delta


(Homo sapiens (human))
BDBM172390
PNG
(US9090618, H56b(ii) | US9598411, Ref. No. H56b(ii))
Show SMILES OC(=O)CN1CCCC[C@@H]1c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1S/C32H46N4O2/c37-31(38)21-34-15-6-5-14-30(34)32-33-28-12-3-4-13-29(28)36(32)27-19-24-10-7-11-25(20-27)35(24)26-17-22-8-1-2-9-23(16-22)18-26/h3-4,12-13,22-27,30H,1-2,5-11,14-21H2,(H,37,38)/t22-,23+,24-,25+,26-,27+,30-/m1/s1
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Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9598411 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%