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Patent code US9598416

Compile Data Set for Download or QSAR
Found 159 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302404
PNG
(US9598416, Example 50)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(C)CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-14-8-15-10-18(30-21(15)17(9-14)29-3)19-16(11-27-6-4-26(2)5-7-27)12-28-20(19)22(23)24-13-25-28/h8-10,12-13H,4-7,11H2,1-3H3,(H2,23,24,25)
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n/an/a 0.100n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302363
PNG
(N-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC(C)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O2S/c1-10-4-12-6-15(27-18(12)14(5-10)26-3)16-13(7-21-11(2)25)8-24-17(16)19(20)22-9-23-24/h4-6,8-9H,7H2,1-3H3,(H,21,25)(H2,20,22,23)
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n/an/a 0.200n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302362
PNG
(6-[(2-Aminoethoxy)methyl]-5-(7-methoxy-5-methyl-1-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN)cn2ncnc(N)c12
Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,3-4,9,20H2,1-2H3,(H2,21,22,23)
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n/an/a 0.200n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302362
PNG
(6-[(2-Aminoethoxy)methyl]-5-(7-methoxy-5-methyl-1-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN)cn2ncnc(N)c12
Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,3-4,9,20H2,1-2H3,(H2,21,22,23)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302404
PNG
(US9598416, Example 50)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(C)CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H26N6OS/c1-14-8-15-10-18(30-21(15)17(9-14)29-3)19-16(11-27-6-4-26(2)5-7-27)12-28-20(19)22(23)24-13-25-28/h8-10,12-13H,4-7,11H2,1-3H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302385
PNG
(4-{[4-Amino-5-(5-chloro-7-methoxy-1-benzothiophen-...)
Show SMILES COc1cc(Cl)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H19ClN6O2S/c1-29-14-6-13(21)4-11-5-15(30-19(11)14)17-12(7-26-3-2-23-16(28)9-26)8-27-18(17)20(22)24-10-25-27/h4-6,8,10H,2-3,7,9H2,1H3,(H,23,28)(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302379
PNG
(5-(7-Methoxy-5-methyl-1-benzothiophen-2-yl)-6-(pip...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H24N6OS/c1-13-7-14-9-17(29-20(14)16(8-13)28-2)18-15(10-26-5-3-23-4-6-26)11-27-19(18)21(22)24-12-25-27/h7-9,11-12,23H,3-6,10H2,1-2H3,(H2,22,24,25)
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n/an/a 0.400n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302365
PNG
(4-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O2S/c1-12-5-13-7-16(30-20(13)15(6-12)29-2)18-14(8-26-4-3-23-17(28)10-26)9-27-19(18)21(22)24-11-25-27/h5-7,9,11H,3-4,8,10H2,1-2H3,(H,23,28)(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302381
PNG
((3S)-3-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothi...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN[C@H]2CCNC2=O)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O2S/c1-11-5-12-7-16(30-19(12)15(6-11)29-2)17-13(8-24-14-3-4-23-21(14)28)9-27-18(17)20(22)25-10-26-27/h5-7,9-10,14,24H,3-4,8H2,1-2H3,(H,23,28)(H2,22,25,26)/t14-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302420
PNG
(US9598416, Example 66)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CC[C@@H](C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-19(31-22(15)18(8-14)30-4)20-16(10-28-6-5-17(12-28)27(2)3)11-29-21(20)23(24)25-13-26-29/h7-9,11,13,17H,5-6,10,12H2,1-4H3,(H2,24,25,26)/t17-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302385
PNG
(4-{[4-Amino-5-(5-chloro-7-methoxy-1-benzothiophen-...)
Show SMILES COc1cc(Cl)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H19ClN6O2S/c1-29-14-6-13(21)4-11-5-15(30-19(11)14)17-12(7-26-3-2-23-16(28)9-26)8-27-18(17)20(22)24-10-25-27/h4-6,8,10H,2-3,7,9H2,1H3,(H,23,28)(H2,22,24,25)
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n/an/a 0.600n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302421
PNG
(US9598416, Example 67)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC(C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C24H30N6OS/c1-15-8-16-10-20(32-23(16)19(9-15)31-4)21-17(12-30-22(21)24(25)26-14-27-30)11-29-7-5-6-18(13-29)28(2)3/h8-10,12,14,18H,5-7,11,13H2,1-4H3,(H2,25,26,27)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302419
PNG
(US9598416, Example 65)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CC[C@H](C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-19(31-22(15)18(8-14)30-4)20-16(10-28-6-5-17(12-28)27(2)3)11-29-21(20)23(24)25-13-26-29/h7-9,11,13,17H,5-6,10,12H2,1-4H3,(H2,24,25,26)/t17-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302379
PNG
(5-(7-Methoxy-5-methyl-1-benzothiophen-2-yl)-6-(pip...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H24N6OS/c1-13-7-14-9-17(29-20(14)16(8-13)28-2)18-15(10-26-5-3-23-4-6-26)11-27-19(18)21(22)24-12-25-27/h7-9,11-12,23H,3-6,10H2,1-2H3,(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302419
PNG
(US9598416, Example 65)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CC[C@H](C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-19(31-22(15)18(8-14)30-4)20-16(10-28-6-5-17(12-28)27(2)3)11-29-21(20)23(24)25-13-26-29/h7-9,11,13,17H,5-6,10,12H2,1-4H3,(H2,24,25,26)/t17-/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302405
PNG
(US9598416, Example 51)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5OS/c1-14-8-15-10-18(29-21(15)17(9-14)28-2)19-16(11-26-6-4-3-5-7-26)12-27-20(19)22(23)24-13-25-27/h8-10,12-13H,3-7,11H2,1-2H3,(H2,23,24,25)
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n/an/a 0.700n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302363
PNG
(N-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC(C)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O2S/c1-10-4-12-6-15(27-18(12)14(5-10)26-3)16-13(7-21-11(2)25)8-24-17(16)19(20)22-9-23-24/h4-6,8-9H,7H2,1-3H3,(H,21,25)(H2,20,22,23)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302368
PNG
(N2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)CC(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N6O2S/c1-11-4-12-6-15(29-19(12)14(5-11)28-3)17-13(7-25(2)9-16(21)27)8-26-18(17)20(22)23-10-24-26/h4-6,8,10H,7,9H2,1-3H3,(H2,21,27)(H2,22,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302422
PNG
(US9598416, Example 68)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCN(C)CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-15-9-16-11-19(31-22(16)18(10-15)30-3)20-17(12-28-6-4-5-27(2)7-8-28)13-29-21(20)23(24)25-14-26-29/h9-11,13-14H,4-8,12H2,1-3H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302381
PNG
((3S)-3-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothi...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN[C@H]2CCNC2=O)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O2S/c1-11-5-12-7-16(30-19(12)15(6-11)29-2)17-13(8-24-14-3-4-23-21(14)28)9-27-18(17)20(22)25-10-26-27/h5-7,9-10,14,24H,3-4,8H2,1-2H3,(H,23,28)(H2,22,25,26)/t14-/m0/s1
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n/an/a 0.900n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302421
PNG
(US9598416, Example 67)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC(C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C24H30N6OS/c1-15-8-16-10-20(32-23(16)19(9-15)31-4)21-17(12-30-22(21)24(25)26-14-27-30)11-29-7-5-6-18(13-29)28(2)3/h8-10,12,14,18H,5-7,11,13H2,1-4H3,(H2,25,26,27)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302420
PNG
(US9598416, Example 66)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CC[C@@H](C2)N(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-14-7-15-9-19(31-22(15)18(8-14)30-4)20-16(10-28-6-5-17(12-28)27(2)3)11-29-21(20)23(24)25-13-26-29/h7-9,11,13,17H,5-6,10,12H2,1-4H3,(H2,24,25,26)/t17-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302401
PNG
(US9598416, Example 47)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5OS/c1-13-7-14-9-17(28-20(14)16(8-13)27-2)18-15(10-25-5-3-4-6-25)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302364
PNG
(2-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)26-2)16-13(8-21-3-4-25)9-24-17(16)19(20)22-10-23-24/h5-7,9-10,21,25H,3-4,8H2,1-2H3,(H2,20,22,23)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302418
PNG
(US9598416, Example 64)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCC(CC2)C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-13-7-15-9-18(32-21(15)17(8-13)31-2)19-16(11-29-20(19)22(24)26-12-27-29)10-28-5-3-14(4-6-28)23(25)30/h7-9,11-12,14H,3-6,10H2,1-2H3,(H2,25,30)(H2,24,26,27)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302365
PNG
(4-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O2S/c1-12-5-13-7-16(30-20(13)15(6-12)29-2)18-14(8-26-4-3-23-17(28)10-26)9-27-19(18)21(22)24-11-25-27/h5-7,9,11H,3-4,8,10H2,1-2H3,(H,23,28)(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302400
PNG
(US9598416, Example 46)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)CCC#N)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6OS/c1-13-7-14-9-17(29-20(14)16(8-13)28-3)18-15(10-26(2)6-4-5-22)11-27-19(18)21(23)24-12-25-27/h7-9,11-12H,4,6,10H2,1-3H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302356
PNG
((2S)-1-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothio...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COC[C@H](C)O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N4O3S/c1-11-4-13-6-16(28-19(13)15(5-11)26-3)17-14(9-27-8-12(2)25)7-24-18(17)20(21)22-10-23-24/h4-7,10,12,25H,8-9H2,1-3H3,(H2,21,22,23)/t12-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302372
PNG
(US9598416, Example 18 | rac-1-{[4-Amino-5-(7-metho...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCC(O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O2S/c1-12-5-13-7-17(29-20(13)16(6-12)28-2)18-14(8-25-4-3-15(27)10-25)9-26-19(18)21(22)23-11-24-26/h5-7,9,11,15,27H,3-4,8,10H2,1-2H3,(H2,22,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302364
PNG
(2-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C19H21N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)26-2)16-13(8-21-3-4-25)9-24-17(16)19(20)22-10-23-24/h5-7,9-10,21,25H,3-4,8H2,1-2H3,(H2,20,22,23)
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n/an/a 1.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302409
PNG
(US9598416, Example 55)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2C)cn2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-12-6-14-8-17(31-20(14)16(7-12)30-3)18-15(9-27-5-4-24-22(29)13(27)2)10-28-19(18)21(23)25-11-26-28/h6-8,10-11,13H,4-5,9H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a 1.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302405
PNG
(US9598416, Example 51)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5OS/c1-14-8-15-10-18(29-21(15)17(9-14)28-2)19-16(11-26-6-4-3-5-7-26)12-27-20(19)22(23)24-13-25-27/h8-10,12-13H,3-7,11H2,1-2H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302422
PNG
(US9598416, Example 68)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCN(C)CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H28N6OS/c1-15-9-16-11-19(31-22(16)18(10-15)30-3)20-17(12-28-6-4-5-27(2)7-8-28)13-29-21(20)23(24)25-14-26-29/h9-11,13-14H,4-8,12H2,1-3H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302372
PNG
(US9598416, Example 18 | rac-1-{[4-Amino-5-(7-metho...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCC(O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O2S/c1-12-5-13-7-17(29-20(13)16(6-12)28-2)18-14(8-25-4-3-15(27)10-25)9-26-19(18)21(22)23-11-24-26/h5-7,9,11,15,27H,3-4,8,10H2,1-2H3,(H2,22,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302418
PNG
(US9598416, Example 64)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCC(CC2)C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-13-7-15-9-18(32-21(15)17(8-13)31-2)19-16(11-29-20(19)22(24)26-12-27-29)10-28-5-3-14(4-6-28)23(25)30/h7-9,11-12,14H,3-6,10H2,1-2H3,(H2,25,30)(H2,24,26,27)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302401
PNG
(US9598416, Example 47)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5OS/c1-13-7-14-9-17(28-20(14)16(8-13)27-2)18-15(10-25-5-3-4-6-25)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302357
PNG
((2S)-2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothio...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CO[C@@H](C)CO)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N4O3S/c1-11-4-13-6-16(28-19(13)15(5-11)26-3)17-14(9-27-12(2)8-25)7-24-18(17)20(21)22-10-23-24/h4-7,10,12,25H,8-9H2,1-3H3,(H2,21,22,23)/t12-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302387
PNG
(4-{[4-Amino-5-(5,7-dimethoxy-1-benzothiophen-2-yl)...)
Show SMILES COc1cc(OC)c2sc(cc2c1)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O3S/c1-29-14-5-12-6-16(31-20(12)15(7-14)30-2)18-13(8-26-4-3-23-17(28)10-26)9-27-19(18)21(22)24-11-25-27/h5-7,9,11H,3-4,8,10H2,1-2H3,(H,23,28)(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302371
PNG
(1-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(C)(C)O)cn2ncnc(N)c12
Show InChI InChI=1S/C21H25N5O2S/c1-12-5-13-7-16(29-19(13)15(6-12)28-4)17-14(8-23-10-21(2,3)27)9-26-18(17)20(22)24-11-25-26/h5-7,9,11,23,27H,8,10H2,1-4H3,(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302371
PNG
(1-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(C)(C)O)cn2ncnc(N)c12
Show InChI InChI=1S/C21H25N5O2S/c1-12-5-13-7-16(29-19(13)15(6-12)28-4)17-14(8-23-10-21(2,3)27)9-26-18(17)20(22)24-11-25-26/h5-7,9,11,23,27H,8,10H2,1-4H3,(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302380
PNG
(US9598416, Example 26 | rac-1-({[4-Amino-5-(7-meth...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(C)O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H23N5O2S/c1-11-4-13-6-16(28-19(13)15(5-11)27-3)17-14(8-22-7-12(2)26)9-25-18(17)20(21)23-10-24-25/h4-6,9-10,12,22,26H,7-8H2,1-3H3,(H2,21,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302380
PNG
(US9598416, Example 26 | rac-1-({[4-Amino-5-(7-meth...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(C)O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H23N5O2S/c1-11-4-13-6-16(28-19(13)15(5-11)27-3)17-14(8-22-7-12(2)26)9-25-18(17)20(21)23-10-24-25/h4-6,9-10,12,22,26H,7-8H2,1-3H3,(H2,21,23,24)
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n/an/a 2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302368
PNG
(N2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)CC(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N6O2S/c1-11-4-12-6-15(29-19(12)14(5-11)28-3)17-13(7-25(2)9-16(21)27)8-26-18(17)20(22)23-10-24-26/h4-6,8,10H,7,9H2,1-3H3,(H2,21,27)(H2,22,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302356
PNG
((2S)-1-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothio...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COC[C@H](C)O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N4O3S/c1-11-4-13-6-16(28-19(13)15(5-11)26-3)17-14(9-27-8-12(2)25)7-24-18(17)20(21)22-10-23-24/h4-7,10,12,25H,8-9H2,1-3H3,(H2,21,22,23)/t12-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302427
PNG
(US9598416, Example 73)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC2CCOC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O2S/c1-12-5-13-7-17(29-20(13)16(6-12)27-2)18-14(8-23-15-3-4-28-10-15)9-26-19(18)21(22)24-11-25-26/h5-7,9,11,15,23H,3-4,8,10H2,1-2H3,(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302408
PNG
(US9598416, Example 54)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCOCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O2S/c1-14-8-15-10-18(30-21(15)17(9-14)28-2)19-16(11-26-4-3-6-29-7-5-26)12-27-20(19)22(23)24-13-25-27/h8-10,12-13H,3-7,11H2,1-2H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302370
PNG
(N2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O2S/c1-10-3-11-5-14(28-18(11)13(4-10)27-2)16-12(6-22-7-15(20)26)8-25-17(16)19(21)23-9-24-25/h3-5,8-9,22H,6-7H2,1-2H3,(H2,20,26)(H2,21,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302400
PNG
(US9598416, Example 46)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)CCC#N)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6OS/c1-13-7-14-9-17(29-20(14)16(8-13)28-3)18-15(10-26(2)6-4-5-22)11-27-19(18)21(23)24-12-25-27/h7-9,11-12H,4,6,10H2,1-3H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302425
PNG
(US9598416, Example 71)
Show SMILES COC(C)CCN(C)Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C23H29N5O2S/c1-14-8-16-10-19(31-22(16)18(9-14)30-5)20-17(11-27(3)7-6-15(2)29-4)12-28-21(20)23(24)25-13-26-28/h8-10,12-13,15H,6-7,11H2,1-5H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302416
PNG
(US9598416, Example 62)
Show SMILES COC1CCCN(Cc2cn3ncnc(N)c3c2-c2cc3cc(C)cc(OC)c3s2)C1
Show InChI InChI=1S/C23H27N5O2S/c1-14-7-15-9-19(31-22(15)18(8-14)30-3)20-16(10-27-6-4-5-17(12-27)29-2)11-28-21(20)23(24)25-13-26-28/h7-9,11,13,17H,4-6,10,12H2,1-3H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302387
PNG
(4-{[4-Amino-5-(5,7-dimethoxy-1-benzothiophen-2-yl)...)
Show SMILES COc1cc(OC)c2sc(cc2c1)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H22N6O3S/c1-29-14-5-12-6-16(31-20(12)15(7-14)30-2)18-13(8-26-4-3-23-17(28)10-26)9-27-19(18)21(22)24-11-25-27/h5-7,9,11H,3-4,8,10H2,1-2H3,(H,23,28)(H2,22,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302409
PNG
(US9598416, Example 55)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2C)cn2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-12-6-14-8-17(31-20(14)16(7-12)30-3)18-15(9-27-5-4-24-22(29)13(27)2)10-28-19(18)21(23)25-11-26-28/h6-8,10-11,13H,4-5,9H2,1-3H3,(H,24,29)(H2,23,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302411
PNG
(US9598416, Example 57)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)C2CCS(=O)(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O3S2/c1-13-6-14-8-18(31-21(14)17(7-13)30-3)19-15(10-27-20(19)22(23)24-12-25-27)9-26(2)16-4-5-32(28,29)11-16/h6-8,10,12,16H,4-5,9,11H2,1-3H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302417
PNG
(US9598416, Example 63)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCC(F)(F)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H21F2N5OS/c1-12-5-13-7-16(30-19(13)15(6-12)29-2)17-14(8-27-4-3-21(22,23)10-27)9-28-18(17)20(24)25-11-26-28/h5-7,9,11H,3-4,8,10H2,1-2H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302410
PNG
(US9598416, Example 56)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20N6O2S/c1-11-3-12-5-15(29-19(12)14(4-11)28-2)17-13(6-25-8-16(27)23-10-25)7-26-18(17)20(21)22-9-24-26/h3-5,7,9H,6,8,10H2,1-2H3,(H,23,27)(H2,21,22,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302384
PNG
(4-{[4-Amino-5-(7-methoxy-1-benzothiophen-2-yl)pyrr...)
Show SMILES COc1cccc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20N6O2S/c1-28-14-4-2-3-12-7-15(29-19(12)14)17-13(8-25-6-5-22-16(27)10-25)9-26-18(17)20(21)23-11-24-26/h2-4,7,9,11H,5-6,8,10H2,1H3,(H,22,27)(H2,21,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302402
PNG
(US9598416, Example 48)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC2CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H21N5OS/c1-11-5-12-7-16(27-19(12)15(6-11)26-2)17-13(8-22-14-3-4-14)9-25-18(17)20(21)23-10-24-25/h5-7,9-10,14,22H,3-4,8H2,1-2H3,(H2,21,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302406
PNG
(US9598416, Example 52)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCOC(C)(C)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H27N5O2S/c1-14-7-15-9-18(31-21(15)17(8-14)29-4)19-16(10-27-5-6-30-23(2,3)12-27)11-28-20(19)22(24)25-13-26-28/h7-9,11,13H,5-6,10,12H2,1-4H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302416
PNG
(US9598416, Example 62)
Show SMILES COC1CCCN(Cc2cn3ncnc(N)c3c2-c2cc3cc(C)cc(OC)c3s2)C1
Show InChI InChI=1S/C23H27N5O2S/c1-14-7-15-9-19(31-22(15)18(8-14)30-3)20-16(10-27-6-4-5-17(12-27)29-2)11-28-21(20)23(24)25-13-26-28/h7-9,11,13,17H,4-6,10,12H2,1-3H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302413
PNG
(US9598416, Example 59)
Show SMILES COC(C)CN(C)Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C22H27N5O2S/c1-13-6-15-8-18(30-21(15)17(7-13)29-5)19-16(10-26(3)9-14(2)28-4)11-27-20(19)22(23)24-12-25-27/h6-8,11-12,14H,9-10H2,1-5H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302360
PNG
(2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O3S/c1-10-3-11-5-14(28-18(11)13(4-10)26-2)16-12(7-27-8-15(20)25)6-24-17(16)19(21)22-9-23-24/h3-6,9H,7-8H2,1-2H3,(H2,20,25)(H2,21,22,23)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302370
PNG
(N2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H20N6O2S/c1-10-3-11-5-14(28-18(11)13(4-10)27-2)16-12(6-22-7-15(20)26)8-25-17(16)19(21)23-9-24-25/h3-5,8-9,22H,6-7H2,1-2H3,(H2,20,26)(H2,21,23,24)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302357
PNG
((2S)-2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothio...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CO[C@@H](C)CO)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N4O3S/c1-11-4-13-6-16(28-19(13)15(5-11)26-3)17-14(9-27-12(2)8-25)7-24-18(17)20(21)22-10-23-24/h4-7,10,12,25H,8-9H2,1-3H3,(H2,21,22,23)/t12-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302411
PNG
(US9598416, Example 57)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)C2CCS(=O)(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O3S2/c1-13-6-14-8-18(31-21(14)17(7-13)30-3)19-15(10-27-20(19)22(23)24-12-25-27)9-26(2)16-4-5-32(28,29)11-16/h6-8,10,12,16H,4-5,9,11H2,1-3H3,(H2,23,24,25)
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n/an/a 4.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302360
PNG
(2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O3S/c1-10-3-11-5-14(28-18(11)13(4-10)26-2)16-12(7-27-8-15(20)25)6-24-17(16)19(21)22-9-23-24/h3-6,9H,7-8H2,1-2H3,(H2,20,25)(H2,21,22,23)
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n/an/a 4.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302423
PNG
(US9598416, Example 69)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC(C2)C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-13-6-15-8-18(32-21(15)17(7-13)31-2)19-16(11-29-20(19)22(24)26-12-27-29)10-28-5-3-4-14(9-28)23(25)30/h6-8,11-12,14H,3-5,9-10H2,1-2H3,(H2,25,30)(H2,24,26,27)
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n/an/a 4.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302392
PNG
(US9598416, Example 38 | [4-Amino-5-(7-methoxy-5-me...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(cn2ncnc(N)c12)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H24N6O2S/c1-13-8-14-10-17(31-20(14)16(9-13)30-3)18-15(11-28-19(18)21(23)24-12-25-28)22(29)27-6-4-26(2)5-7-27/h8-12H,4-7H2,1-3H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302408
PNG
(US9598416, Example 54)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCOCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O2S/c1-14-8-15-10-18(30-21(15)17(9-14)28-2)19-16(11-26-4-3-6-29-7-5-26)12-27-20(19)22(23)24-13-25-27/h8-10,12-13H,3-7,11H2,1-2H3,(H2,23,24,25)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302389
PNG
(4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(cn2ncnc(N)c12)C(N)=O
Show InChI InChI=1S/C17H15N5O2S/c1-8-3-9-5-12(25-15(9)11(4-8)24-2)13-10(17(19)23)6-22-14(13)16(18)20-7-21-22/h3-7H,1-2H3,(H2,19,23)(H2,18,20,21)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302430
PNG
(US9598416, Example 76)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCOC(C)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O2S/c1-13-6-15-8-18(30-21(15)17(7-13)28-3)19-16(10-26-4-5-29-14(2)9-26)11-27-20(19)22(23)24-12-25-27/h6-8,11-12,14H,4-5,9-10H2,1-3H3,(H2,23,24,25)
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n/an/a 4.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302429
PNG
(US9598416, Example 75)
Show SMILES CCN1CCCC1NCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C23H28N6OS/c1-4-28-7-5-6-19(28)25-11-16-12-29-21(23(24)26-13-27-29)20(16)18-10-15-8-14(2)9-17(30-3)22(15)31-18/h8-10,12-13,19,25H,4-7,11H2,1-3H3,(H2,24,26,27)
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n/an/a 5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302428
PNG
(US9598416, Example 74)
Show SMILES CCC(C)NCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H25N5OS/c1-5-13(3)23-9-15-10-26-19(21(22)24-11-25-26)18(15)17-8-14-6-12(2)7-16(27-4)20(14)28-17/h6-8,10-11,13,23H,5,9H2,1-4H3,(H2,22,24,25)
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n/an/a 5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302384
PNG
(4-{[4-Amino-5-(7-methoxy-1-benzothiophen-2-yl)pyrr...)
Show SMILES COc1cccc2cc(sc12)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20N6O2S/c1-28-14-4-2-3-12-7-15(29-19(12)14)17-13(8-25-6-5-22-16(27)10-25)9-26-18(17)20(21)23-11-24-26/h2-4,7,9,11H,5-6,8,10H2,1H3,(H,22,27)(H2,21,23,24)
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n/an/a 5.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302426
PNG
(US9598416, Example 72)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC2CCS(=O)(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O3S2/c1-12-5-13-7-17(30-20(13)16(6-12)29-2)18-14(8-23-15-3-4-31(27,28)10-15)9-26-19(18)21(22)24-11-25-26/h5-7,9,11,15,23H,3-4,8,10H2,1-2H3,(H2,22,24,25)
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n/an/a 5.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302377
PNG
(5-(7-Methoxy-5-methyl-1-benzothiophen-2-yl)-6-(mor...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCOCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O2S/c1-13-7-14-9-17(29-20(14)16(8-13)27-2)18-15(10-25-3-5-28-6-4-25)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,24)
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n/an/a 5.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302382
PNG
(6-(Ethoxymethyl)-5-(7-methoxy-5-methyl-1-benzothio...)
Show SMILES CCOCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C19H20N4O2S/c1-4-25-9-13-8-23-17(19(20)21-10-22-23)16(13)15-7-12-5-11(2)6-14(24-3)18(12)26-15/h5-8,10H,4,9H2,1-3H3,(H2,20,21,22)
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n/an/a 5.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302423
PNG
(US9598416, Example 69)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC(C2)C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-13-6-15-8-18(32-21(15)17(7-13)31-2)19-16(11-29-20(19)22(24)26-12-27-29)10-28-5-3-4-14(9-28)23(25)30/h6-8,11-12,14H,3-5,9-10H2,1-2H3,(H2,25,30)(H2,24,26,27)
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n/an/a 5.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302361
PNG
(2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C19H20N4O3S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-24)8-23-17(16)19(20)21-10-22-23/h5-8,10,24H,3-4,9H2,1-2H3,(H2,20,21,22)
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n/an/a 5.80n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302412
PNG
(US9598416, Example 58)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(CC2)C2CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C24H28N6OS/c1-15-9-16-11-20(32-23(16)19(10-15)31-2)21-17(13-30-22(21)24(25)26-14-27-30)12-28-5-7-29(8-6-28)18-3-4-18/h9-11,13-14,18H,3-8,12H2,1-2H3,(H2,25,26,27)
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n/an/a 6.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302402
PNG
(US9598416, Example 48)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC2CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H21N5OS/c1-11-5-12-7-16(27-19(12)15(6-11)26-2)17-13(8-22-14-3-4-14)9-25-18(17)20(21)23-10-24-25/h5-7,9-10,14,22H,3-4,8H2,1-2H3,(H2,21,23,24)
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n/an/a 6.30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302417
PNG
(US9598416, Example 63)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCC(F)(F)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H21F2N5OS/c1-12-5-13-7-16(30-19(13)15(6-12)29-2)17-14(8-27-4-3-21(22,23)10-27)9-28-18(17)20(24)25-11-26-28/h5-7,9,11H,3-4,8,10H2,1-2H3,(H2,24,25,26)
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n/an/a 6.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302430
PNG
(US9598416, Example 76)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCOC(C)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O2S/c1-13-6-15-8-18(30-21(15)17(7-13)28-3)19-16(10-26-4-5-29-14(2)9-26)11-27-20(19)22(23)24-12-25-27/h6-8,11-12,14H,4-5,9-10H2,1-3H3,(H2,23,24,25)
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n/an/a 7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302375
PNG
(1-(4-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothioph...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(CC2)C(C)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-14-8-16-10-19(32-22(16)18(9-14)31-3)20-17(12-29-21(20)23(24)25-13-26-29)11-27-4-6-28(7-5-27)15(2)30/h8-10,12-13H,4-7,11H2,1-3H3,(H2,24,25,26)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302412
PNG
(US9598416, Example 58)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(CC2)C2CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C24H28N6OS/c1-15-9-16-11-20(32-23(16)19(10-15)31-2)21-17(13-30-22(21)24(25)26-14-27-30)12-28-5-7-29(8-6-28)18-3-4-18/h9-11,13-14,18H,3-8,12H2,1-2H3,(H2,25,26,27)
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302424
PNG
(US9598416, Example 70)
Show SMILES COCCN(C)Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H25N5O2S/c1-13-7-14-9-17(29-20(14)16(8-13)28-4)18-15(10-25(2)5-6-27-3)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,5-6,10H2,1-4H3,(H2,22,23,24)
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n/an/a 7.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302391
PNG
(4-Amino-N-ethyl-5-(7-methoxy-5-methyl-1-benzothiop...)
Show SMILES CCNC(=O)c1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C19H19N5O2S/c1-4-21-19(25)12-8-24-16(18(20)22-9-23-24)15(12)14-7-11-5-10(2)6-13(26-3)17(11)27-14/h5-9H,4H2,1-3H3,(H,21,25)(H2,20,22,23)
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n/an/a 7.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302410
PNG
(US9598416, Example 56)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20N6O2S/c1-11-3-12-5-15(29-19(12)14(4-11)28-2)17-13(6-25-8-16(27)23-10-25)7-26-18(17)20(21)22-9-24-26/h3-5,7,9H,6,8,10H2,1-2H3,(H,23,27)(H2,21,22,24)
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n/an/a 7.80n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302406
PNG
(US9598416, Example 52)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCOC(C)(C)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H27N5O2S/c1-14-7-15-9-18(31-21(15)17(8-14)29-4)19-16(10-27-5-6-30-23(2,3)12-27)11-28-20(19)22(24)25-13-26-28/h7-9,11,13H,5-6,10,12H2,1-4H3,(H2,24,25,26)
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n/an/a 7.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302378
PNG
(N-[2-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiop...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCCNC(C)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C21H24N6O2S/c1-12-6-14-8-17(30-20(14)16(7-12)29-3)18-15(9-23-4-5-24-13(2)28)10-27-19(18)21(22)25-11-26-27/h6-8,10-11,23H,4-5,9H2,1-3H3,(H,24,28)(H2,22,25,26)
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n/an/a 8.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302394
PNG
(US9598416, Example 40)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC#N)cn2ncnc(N)c12
Show InChI InChI=1S/C19H17N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,4,9H2,1-2H3,(H2,21,22,23)
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n/an/a 9.10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302398
PNG
(US9598416, Example 44)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN2CCCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C24H29N5O2S/c1-16-10-17-12-20(32-23(17)19(11-16)30-2)21-18(13-29-22(21)24(25)26-15-27-29)14-31-9-8-28-6-4-3-5-7-28/h10-13,15H,3-9,14H2,1-2H3,(H2,25,26,27)
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n/an/a 9.30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302361
PNG
(2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C19H20N4O3S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-24)8-23-17(16)19(20)21-10-22-23/h5-8,10,24H,3-4,9H2,1-2H3,(H2,20,21,22)
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n/an/a 9.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302355
PNG
(3-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N4O3S/c1-12-6-13-8-16(28-19(13)15(7-12)26-2)17-14(10-27-5-3-4-25)9-24-18(17)20(21)22-11-23-24/h6-9,11,25H,3-5,10H2,1-2H3,(H2,21,22,23)
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n/an/a 10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302376
PNG
(US9598416, Example 22 | tert-Butyl 4-{[4-amino-5-(...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(CC2)C(=O)OC(C)(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C26H32N6O3S/c1-16-10-17-12-20(36-23(17)19(11-16)34-5)21-18(14-32-22(21)24(27)28-15-29-32)13-30-6-8-31(9-7-30)25(33)35-26(2,3)4/h10-12,14-15H,6-9,13H2,1-5H3,(H2,27,28,29)
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n/an/a 10.6n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302397
PNG
(US9598416, Example 43)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN2CCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H27N5O2S/c1-15-9-16-11-19(31-22(16)18(10-15)29-2)20-17(12-28-21(20)23(24)25-14-26-28)13-30-8-7-27-5-3-4-6-27/h9-12,14H,3-8,13H2,1-2H3,(H2,24,25,26)
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n/an/a 10.7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302376
PNG
(US9598416, Example 22 | tert-Butyl 4-{[4-amino-5-(...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(CC2)C(=O)OC(C)(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C26H32N6O3S/c1-16-10-17-12-20(36-23(17)19(11-16)34-5)21-18(14-32-22(21)24(27)28-15-29-32)13-30-6-8-31(9-7-30)25(33)35-26(2,3)4/h10-12,14-15H,6-9,13H2,1-5H3,(H2,27,28,29)
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n/an/a 10.8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302373
PNG
(US9598416, Example 19 | rac-1-{[4-Amino-5-(7-metho...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC2C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-12-6-13-8-17(31-20(13)16(7-12)30-2)18-14(9-27-5-3-4-15(27)22(24)29)10-28-19(18)21(23)25-11-26-28/h6-8,10-11,15H,3-5,9H2,1-2H3,(H2,24,29)(H2,23,25,26)
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n/an/a 11.2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302378
PNG
(N-[2-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiop...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCCNC(C)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C21H24N6O2S/c1-12-6-14-8-17(30-20(14)16(7-12)29-3)18-15(9-23-4-5-24-13(2)28)10-27-19(18)21(22)25-11-26-27/h6-8,10-11,23H,4-5,9H2,1-3H3,(H,24,28)(H2,22,25,26)
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n/an/a 11.6n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302366
PNG
(US9598416, Example 12 | rac-N2-{[4-Amino-5-(7-meth...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC(C)C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N6O2S/c1-10-4-12-6-15(29-18(12)14(5-10)28-3)16-13(7-23-11(2)20(22)27)8-26-17(16)19(21)24-9-25-26/h4-6,8-9,11,23H,7H2,1-3H3,(H2,22,27)(H2,21,24,25)
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n/an/a 11.6n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302414
PNG
(US9598416, Example 60)
Show SMILES COC1CCN(Cc2cn3ncnc(N)c3c2-c2cc3cc(C)cc(OC)c3s2)CC1
Show InChI InChI=1S/C23H27N5O2S/c1-14-8-15-10-19(31-22(15)18(9-14)30-3)20-16(11-27-6-4-17(29-2)5-7-27)12-28-21(20)23(24)25-13-26-28/h8-10,12-13,17H,4-7,11H2,1-3H3,(H2,24,25,26)
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n/an/a 12.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302395
PNG
(US9598416, Example 41)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCCC#N)cn2ncnc(N)c12
Show InChI InChI=1S/C21H21N5O2S/c1-13-7-14-9-17(29-20(14)16(8-13)27-2)18-15(11-28-6-4-3-5-22)10-26-19(18)21(23)24-12-25-26/h7-10,12H,3-4,6,11H2,1-2H3,(H2,23,24,25)
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n/an/a 12.7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302373
PNG
(US9598416, Example 19 | rac-1-{[4-Amino-5-(7-metho...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCCC2C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O2S/c1-12-6-13-8-17(31-20(13)16(7-12)30-2)18-14(9-27-5-3-4-15(27)22(24)29)10-28-19(18)21(23)25-11-26-28/h6-8,10-11,15H,3-5,9H2,1-2H3,(H2,24,29)(H2,23,25,26)
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n/an/a 13.8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302426
PNG
(US9598416, Example 72)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC2CCS(=O)(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O3S2/c1-12-5-13-7-17(30-20(13)16(6-12)29-2)18-14(8-23-15-3-4-31(27,28)10-15)9-26-19(18)21(22)24-11-25-26/h5-7,9,11,15,23H,3-4,8,10H2,1-2H3,(H2,22,24,25)
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n/an/a 14n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302397
PNG
(US9598416, Example 43)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN2CCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H27N5O2S/c1-15-9-16-11-19(31-22(16)18(10-15)29-2)20-17(12-28-21(20)23(24)25-14-26-28)13-30-8-7-27-5-3-4-6-27/h9-12,14H,3-8,13H2,1-2H3,(H2,24,25,26)
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n/an/a 14.2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302382
PNG
(6-(Ethoxymethyl)-5-(7-methoxy-5-methyl-1-benzothio...)
Show SMILES CCOCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C19H20N4O2S/c1-4-25-9-13-8-23-17(19(20)21-10-22-23)16(13)15-7-12-5-11(2)6-14(24-3)18(12)26-15/h5-8,10H,4,9H2,1-3H3,(H2,20,21,22)
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n/an/a 14.2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302403
PNG
(US9598416, Example 49)
Show SMILES COCCN(Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1)C(C)C
Show InChI InChI=1S/C23H29N5O2S/c1-14(2)27(6-7-29-4)11-17-12-28-21(23(24)25-13-26-28)20(17)19-10-16-8-15(3)9-18(30-5)22(16)31-19/h8-10,12-14H,6-7,11H2,1-5H3,(H2,24,25,26)
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n/an/a 14.2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302427
PNG
(US9598416, Example 73)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC2CCOC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O2S/c1-12-5-13-7-17(29-20(13)16(6-12)27-2)18-14(8-23-15-3-4-28-10-15)9-26-19(18)21(22)24-11-25-26/h5-7,9,11,15,23H,3-4,8,10H2,1-2H3,(H2,22,24,25)
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n/an/a 14.3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302415
PNG
(US9598416, Example 61)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)CC(F)(F)F)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20F3N5OS/c1-11-4-12-6-15(30-18(12)14(5-11)29-3)16-13(7-27(2)9-20(21,22)23)8-28-17(16)19(24)25-10-26-28/h4-6,8,10H,7,9H2,1-3H3,(H2,24,25,26)
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n/an/a 14.6n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302394
PNG
(US9598416, Example 40)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC#N)cn2ncnc(N)c12
Show InChI InChI=1S/C19H17N5O2S/c1-11-5-12-7-15(27-18(12)14(6-11)25-2)16-13(9-26-4-3-20)8-24-17(16)19(21)22-10-23-24/h5-8,10H,4,9H2,1-2H3,(H2,21,22,23)
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n/an/a 14.7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302429
PNG
(US9598416, Example 75)
Show SMILES CCN1CCCC1NCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C23H28N6OS/c1-4-28-7-5-6-19(28)25-11-16-12-29-21(23(24)26-13-27-29)20(16)18-10-15-8-14(2)9-17(30-3)22(15)31-18/h8-10,12-13,19,25H,4-7,11H2,1-3H3,(H2,24,26,27)
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n/an/a 14.7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302398
PNG
(US9598416, Example 44)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN2CCCCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C24H29N5O2S/c1-16-10-17-12-20(32-23(17)19(11-16)30-2)21-18(13-29-22(21)24(25)26-15-27-29)14-31-9-8-28-6-4-3-5-7-28/h10-13,15H,3-9,14H2,1-2H3,(H2,25,26,27)
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n/an/a 15.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302407
PNG
(US9598416, Example 53)
Show SMILES COC1CN(Cc2cn3ncnc(N)c3c2-c2cc3cc(C)cc(OC)c3s2)C1
Show InChI InChI=1S/C21H23N5O2S/c1-12-4-13-6-17(29-20(13)16(5-12)28-3)18-14(7-25-9-15(10-25)27-2)8-26-19(18)21(22)23-11-24-26/h4-6,8,11,15H,7,9-10H2,1-3H3,(H2,22,23,24)
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n/an/a 15.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302367
PNG
(N2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES CNC(=O)CNCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C20H22N6O2S/c1-11-4-12-6-15(29-19(12)14(5-11)28-3)17-13(7-23-8-16(27)22-2)9-26-18(17)20(21)24-10-25-26/h4-6,9-10,23H,7-8H2,1-3H3,(H,22,27)(H2,21,24,25)
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n/an/a 15.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302374
PNG
(3-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C20H23N5O2S/c1-12-6-13-8-16(28-19(13)15(7-12)27-2)17-14(9-22-4-3-5-26)10-25-18(17)20(21)23-11-24-25/h6-8,10-11,22,26H,3-5,9H2,1-2H3,(H2,21,23,24)
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n/an/a 15.2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302431
PNG
(US9598416, Example 77)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCS(=O)(=O)CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O3S2/c1-13-7-14-9-17(30-20(14)16(8-13)29-2)18-15(10-25-3-5-31(27,28)6-4-25)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,24)
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n/an/a 15.3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302424
PNG
(US9598416, Example 70)
Show SMILES COCCN(C)Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H25N5O2S/c1-13-7-14-9-17(29-20(14)16(8-13)28-4)18-15(10-25(2)5-6-27-3)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,5-6,10H2,1-4H3,(H2,22,23,24)
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n/an/a 16.4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302403
PNG
(US9598416, Example 49)
Show SMILES COCCN(Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1)C(C)C
Show InChI InChI=1S/C23H29N5O2S/c1-14(2)27(6-7-29-4)11-17-12-28-21(23(24)25-13-26-28)20(17)19-10-16-8-15(3)9-18(30-5)22(16)31-19/h8-10,12-14H,6-7,11H2,1-5H3,(H2,24,25,26)
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n/an/a 17.3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302377
PNG
(5-(7-Methoxy-5-methyl-1-benzothiophen-2-yl)-6-(mor...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCOCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O2S/c1-13-7-14-9-17(29-20(14)16(8-13)27-2)18-15(10-25-3-5-28-6-4-25)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,24)
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n/an/a 17.4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302413
PNG
(US9598416, Example 59)
Show SMILES COC(C)CN(C)Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C22H27N5O2S/c1-13-6-15-8-18(30-21(15)17(7-13)29-5)19-16(10-26(3)9-14(2)28-4)11-27-20(19)22(23)24-12-25-27/h6-8,11-12,14H,9-10H2,1-5H3,(H2,23,24,25)
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n/an/a 17.9n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302355
PNG
(3-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N4O3S/c1-12-6-13-8-16(28-19(13)15(7-12)26-2)17-14(10-27-5-3-4-25)9-24-18(17)20(21)22-11-23-24/h6-9,11,25H,3-5,10H2,1-2H3,(H2,21,22,23)
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n/an/a 18.2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302383
PNG
(4-{[4-Amino-5-(5-methyl-1-benzothiophen-2-yl)pyrro...)
Show SMILES Cc1ccc2sc(cc2c1)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20N6OS/c1-12-2-3-15-13(6-12)7-16(28-15)18-14(8-25-5-4-22-17(27)10-25)9-26-19(18)20(21)23-11-24-26/h2-3,6-7,9,11H,4-5,8,10H2,1H3,(H,22,27)(H2,21,23,24)
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n/an/a 18.7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302374
PNG
(3-({[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCCCO)cn2ncnc(N)c12
Show InChI InChI=1S/C20H23N5O2S/c1-12-6-13-8-16(28-19(13)15(7-12)27-2)17-14(9-22-4-3-5-26)10-25-18(17)20(21)23-11-24-25/h6-8,10-11,22,26H,3-5,9H2,1-2H3,(H2,21,23,24)
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n/an/a 19.9n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302388
PNG
(4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(cn2ncnc(N)c12)C(O)=O
Show InChI InChI=1S/C17H14N4O3S/c1-8-3-9-5-12(25-15(9)11(4-8)24-2)13-10(17(22)23)6-21-14(13)16(18)19-7-20-21/h3-7H,1-2H3,(H,22,23)(H2,18,19,20)
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n/an/a 20.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302395
PNG
(US9598416, Example 41)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCCC#N)cn2ncnc(N)c12
Show InChI InChI=1S/C21H21N5O2S/c1-13-7-14-9-17(29-20(14)16(8-13)27-2)18-15(11-28-6-4-3-5-22)10-26-19(18)21(23)24-12-25-26/h7-10,12H,3-4,6,11H2,1-2H3,(H2,23,24,25)
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n/an/a 22.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302386
PNG
(US9598416, Example 32 | [4-Amino-5-(7-methoxy-5-me...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CO)cn2ncnc(N)c12
Show InChI InChI=1S/C17H16N4O2S/c1-9-3-10-5-13(24-16(10)12(4-9)23-2)14-11(7-22)6-21-15(14)17(18)19-8-20-21/h3-6,8,22H,7H2,1-2H3,(H2,18,19,20)
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n/an/a 22.2n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302383
PNG
(4-{[4-Amino-5-(5-methyl-1-benzothiophen-2-yl)pyrro...)
Show SMILES Cc1ccc2sc(cc2c1)-c1c(CN2CCNC(=O)C2)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20N6OS/c1-12-2-3-15-13(6-12)7-16(28-15)18-14(8-25-5-4-22-17(27)10-25)9-26-19(18)20(21)23-11-24-26/h2-3,6-7,9,11H,4-5,8,10H2,1H3,(H,22,27)(H2,21,23,24)
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n/an/a 24.3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302399
PNG
(US9598416, Example 45)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCCN(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C22H27N5O2S/c1-14-8-15-10-18(30-21(15)17(9-14)28-4)19-16(12-29-7-5-6-26(2)3)11-27-20(19)22(23)24-13-25-27/h8-11,13H,5-7,12H2,1-4H3,(H2,23,24,25)
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n/an/a 24.8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302425
PNG
(US9598416, Example 71)
Show SMILES COC(C)CCN(C)Cc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C23H29N5O2S/c1-14-8-16-10-19(31-22(16)18(9-14)30-5)20-17(11-27(3)7-6-15(2)29-4)12-28-21(20)23(24)25-13-26-28/h8-10,12-13,15H,6-7,11H2,1-5H3,(H2,24,25,26)
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n/an/a 25n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302375
PNG
(1-(4-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothioph...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCN(CC2)C(C)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O2S/c1-14-8-16-10-19(32-22(16)18(9-14)31-3)20-17(12-29-21(20)23(24)25-13-26-29)11-27-4-6-28(7-5-27)15(2)30/h8-10,12-13H,4-7,11H2,1-3H3,(H2,24,25,26)
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n/an/a 27.9n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302407
PNG
(US9598416, Example 53)
Show SMILES COC1CN(Cc2cn3ncnc(N)c3c2-c2cc3cc(C)cc(OC)c3s2)C1
Show InChI InChI=1S/C21H23N5O2S/c1-12-4-13-6-17(29-20(13)16(5-12)28-3)18-14(7-25-9-15(10-25)27-2)8-26-19(18)21(22)23-11-24-26/h4-6,8,11,15H,7,9-10H2,1-3H3,(H2,22,23,24)
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n/an/a 29n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302399
PNG
(US9598416, Example 45)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCCN(C)C)cn2ncnc(N)c12
Show InChI InChI=1S/C22H27N5O2S/c1-14-8-15-10-18(30-21(15)17(9-14)28-4)19-16(12-29-7-5-6-26(2)3)11-27-20(19)22(23)24-13-25-27/h8-11,13H,5-7,12H2,1-4H3,(H2,23,24,25)
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n/an/a 29.4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302396
PNG
(US9598416, Example 42)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN2CCOCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H27N5O3S/c1-15-9-16-11-19(32-22(16)18(10-15)29-2)20-17(12-28-21(20)23(24)25-14-26-28)13-31-8-5-27-3-6-30-7-4-27/h9-12,14H,3-8,13H2,1-2H3,(H2,24,25,26)
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n/an/a 30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302414
PNG
(US9598416, Example 60)
Show SMILES COC1CCN(Cc2cn3ncnc(N)c3c2-c2cc3cc(C)cc(OC)c3s2)CC1
Show InChI InChI=1S/C23H27N5O2S/c1-14-8-15-10-19(31-22(15)18(9-14)30-3)20-16(11-27-6-4-17(29-2)5-7-27)12-28-21(20)23(24)25-13-26-28/h8-10,12-13,17H,4-7,11H2,1-3H3,(H2,24,25,26)
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n/an/a 32.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302415
PNG
(US9598416, Example 61)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN(C)CC(F)(F)F)cn2ncnc(N)c12
Show InChI InChI=1S/C20H20F3N5OS/c1-11-4-12-6-15(30-18(12)14(5-11)29-3)16-13(7-27(2)9-20(21,22)23)8-28-17(16)19(24)25-10-26-28/h4-6,8,10H,7,9H2,1-3H3,(H2,24,25,26)
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n/an/a 32.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302428
PNG
(US9598416, Example 74)
Show SMILES CCC(C)NCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H25N5OS/c1-5-13(3)23-9-15-10-26-19(21(22)24-11-25-26)18(15)17-8-14-6-12(2)7-16(27-4)20(14)28-17/h6-8,10-11,13,23H,5,9H2,1-4H3,(H2,22,24,25)
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n/an/a 33.8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302431
PNG
(US9598416, Example 77)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCS(=O)(=O)CC2)cn2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O3S2/c1-13-7-14-9-17(30-20(14)16(8-13)29-2)18-15(10-25-3-5-31(27,28)6-4-25)11-26-19(18)21(22)23-12-24-26/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,24)
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n/an/a 35.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302390
PNG
(4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(cn2ncnc(N)c12)C(=O)N(C)C
Show InChI InChI=1S/C19H19N5O2S/c1-10-5-11-7-14(27-17(11)13(6-10)26-4)15-12(19(25)23(2)3)8-24-16(15)18(20)21-9-22-24/h5-9H,1-4H3,(H2,20,21,22)
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n/an/a 37.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302358
PNG
(Ethyl {[4-amino-5-(7-methoxy-5-methyl-1-benzothiop...)
Show SMILES CCOC(=O)COCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H22N4O4S/c1-4-29-17(26)10-28-9-14-8-25-19(21(22)23-11-24-25)18(14)16-7-13-5-12(2)6-15(27-3)20(13)30-16/h5-8,11H,4,9-10H2,1-3H3,(H2,22,23,24)
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n/an/a 38.4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302366
PNG
(US9598416, Example 12 | rac-N2-{[4-Amino-5-(7-meth...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNC(C)C(N)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C20H22N6O2S/c1-10-4-12-6-15(29-18(12)14(5-10)28-3)16-13(7-23-11(2)20(22)27)8-26-17(16)19(21)24-9-25-26/h4-6,8-9,11,23H,7H2,1-3H3,(H2,22,27)(H2,21,24,25)
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n/an/a 40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302396
PNG
(US9598416, Example 42)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCN2CCOCC2)cn2ncnc(N)c12
Show InChI InChI=1S/C23H27N5O3S/c1-15-9-16-11-19(32-22(16)18(10-15)29-2)20-17(12-28-21(20)23(24)25-14-26-28)13-31-8-5-27-3-6-30-7-4-27/h9-12,14H,3-8,13H2,1-2H3,(H2,24,25,26)
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n/an/a 40.8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302367
PNG
(N2-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen...)
Show SMILES CNC(=O)CNCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C20H22N6O2S/c1-11-4-12-6-15(29-19(12)14(5-11)28-3)17-13(7-23-8-16(27)22-2)9-26-18(17)20(21)24-10-25-26/h4-6,9-10,23H,7-8H2,1-3H3,(H,22,27)(H2,21,24,25)
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n/an/a 47.6n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302358
PNG
(Ethyl {[4-amino-5-(7-methoxy-5-methyl-1-benzothiop...)
Show SMILES CCOC(=O)COCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H22N4O4S/c1-4-29-17(26)10-28-9-14-8-25-19(21(22)23-11-24-25)18(14)16-7-13-5-12(2)6-15(27-3)20(13)30-16/h5-8,11H,4,9-10H2,1-3H3,(H2,22,23,24)
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n/an/a 49.9n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302369
PNG
(Ethyl N-{[4-amino-5-(7-methoxy-5-methyl-1-benzothi...)
Show SMILES CCOC(=O)CNCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H23N5O3S/c1-4-29-17(27)9-23-8-14-10-26-19(21(22)24-11-25-26)18(14)16-7-13-5-12(2)6-15(28-3)20(13)30-16/h5-7,10-11,23H,4,8-9H2,1-3H3,(H2,22,24,25)
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n/an/a 50.3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302393
PNG
(4-{[4-Amino-5-(7-methoxy-5-methyl-1-benzothiophen-...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(cn2ncnc(N)c12)C(=O)N1CCNC(=O)C1
Show InChI InChI=1S/C21H20N6O3S/c1-11-5-12-7-15(31-19(12)14(6-11)30-2)17-13(8-27-18(17)20(22)24-10-25-27)21(29)26-4-3-23-16(28)9-26/h5-8,10H,3-4,9H2,1-2H3,(H,23,28)(H2,22,24,25)
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n/an/a 51.7n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302359
PNG
(US9598416, Example 5 | {[4-Amino-5-(7-methoxy-5-me...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC(O)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H18N4O4S/c1-10-3-11-5-14(28-18(11)13(4-10)26-2)16-12(7-27-8-15(24)25)6-23-17(16)19(20)21-9-22-23/h3-6,9H,7-8H2,1-2H3,(H,24,25)(H2,20,21,22)
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n/an/a 72.4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM302359
PNG
(US9598416, Example 5 | {[4-Amino-5-(7-methoxy-5-me...)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC(O)=O)cn2ncnc(N)c12
Show InChI InChI=1S/C19H18N4O4S/c1-10-3-11-5-14(28-18(11)13(4-10)26-2)16-12(7-27-8-15(24)25)6-23-17(16)19(20)21-9-22-23/h3-6,9H,7-8H2,1-2H3,(H,24,25)(H2,20,21,22)
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n/an/a 75.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM302369
PNG
(Ethyl N-{[4-amino-5-(7-methoxy-5-methyl-1-benzothi...)
Show SMILES CCOC(=O)CNCc1cn2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C21H23N5O3S/c1-4-29-17(27)9-23-8-14-10-26-19(21(22)24-11-25-26)18(14)16-7-13-5-12(2)6-15(28-3)20(13)30-16/h5-7,10-11,23H,4,8-9H2,1-3H3,(H2,22,24,25)
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n/an/a 87.1n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM255740
PNG
(US9475815, WO 2007/61737: 5 | US9598416, Example 5...)
Show SMILES Cc1ccc2[nH]c(cc2c1)-c1nc(C2CCC2)n2ccnc(N)c12
Show InChI InChI=1S/C19H19N5/c1-11-5-6-14-13(9-11)10-15(22-14)16-17-18(20)21-7-8-24(17)19(23-16)12-3-2-4-12/h5-10,12,22H,2-4H2,1H3,(H2,20,21)
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n/an/a 250n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM255746
PNG
(US9475815, WO 2007/61737: 210 | US9598416, Example...)
Show SMILES Cc1c(sc2ccccc12)-c1nc(C2CCC2)n2ccnc(N)c12
Show InChI InChI=1S/C19H18N4S/c1-11-13-7-2-3-8-14(13)24-17(11)15-16-18(20)21-9-10-23(16)19(22-15)12-5-4-6-12/h2-3,7-10,12H,4-6H2,1H3,(H2,20,21)
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n/an/a 456n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM255740
PNG
(US9475815, WO 2007/61737: 5 | US9598416, Example 5...)
Show SMILES Cc1ccc2[nH]c(cc2c1)-c1nc(C2CCC2)n2ccnc(N)c12
Show InChI InChI=1S/C19H19N5/c1-11-5-6-14-13(9-11)10-15(22-14)16-17-18(20)21-7-8-24(17)19(23-16)12-3-2-4-12/h5-10,12,22H,2-4H2,1H3,(H2,20,21)
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n/an/a 500n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM255742
PNG
(US9475815, WO 2007/61737: 120 | US9598416, Example...)
Show SMILES Nc1nccn2c(nc(-c3cc4ccccc4s3)c12)C1CCC1
Show InChI InChI=1S/C18H16N4S/c19-17-16-15(14-10-12-4-1-2-7-13(12)23-14)21-18(11-5-3-6-11)22(16)9-8-20-17/h1-2,4,7-11H,3,5-6H2,(H2,19,20)
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n/an/a 506n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM255746
PNG
(US9475815, WO 2007/61737: 210 | US9598416, Example...)
Show SMILES Cc1c(sc2ccccc12)-c1nc(C2CCC2)n2ccnc(N)c12
Show InChI InChI=1S/C19H18N4S/c1-11-13-7-2-3-8-14(13)24-17(11)15-16-18(20)21-9-10-23(16)19(22-15)12-5-4-6-12/h2-3,7-10,12H,4-6H2,1H3,(H2,20,21)
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n/an/a 554n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM255742
PNG
(US9475815, WO 2007/61737: 120 | US9598416, Example...)
Show SMILES Nc1nccn2c(nc(-c3cc4ccccc4s3)c12)C1CCC1
Show InChI InChI=1S/C18H16N4S/c19-17-16-15(14-10-12-4-1-2-7-13(12)23-14)21-18(11-5-3-6-11)22(16)9-8-20-17/h1-2,4,7-11H,3,5-6H2,(H2,19,20)
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n/an/a 985n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM255739
PNG
(US9475815, WO 2007/61737: 4 | US9598416, Example 4...)
Show SMILES Nc1nccn2c(nc(-c3ccc4sccc4c3)c12)C1CCC1
Show InChI InChI=1S/C18H16N4S/c19-17-16-15(13-4-5-14-12(10-13)6-9-23-14)21-18(11-2-1-3-11)22(16)8-7-20-17/h4-11H,1-3H2,(H2,19,20)
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n/an/a 2.40E+3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM255747
PNG
(US9475815, WO 2007/61737: 233 | US9598416, Example...)
Show SMILES Nc1nccn2c(nc(-c3cc4cccc(Cl)c4s3)c12)C1CCC1
Show InChI InChI=1S/C18H15ClN4S/c19-12-6-2-5-11-9-13(24-16(11)12)14-15-17(20)21-7-8-23(15)18(22-14)10-3-1-4-10/h2,5-10H,1,3-4H2,(H2,20,21)
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n/an/a 4.60E+3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM255747
PNG
(US9475815, WO 2007/61737: 233 | US9598416, Example...)
Show SMILES Nc1nccn2c(nc(-c3cc4cccc(Cl)c4s3)c12)C1CCC1
Show InChI InChI=1S/C18H15ClN4S/c19-12-6-2-5-11-9-13(24-16(11)12)14-15-17(20)21-7-8-23(15)18(22-14)10-3-1-4-10/h2,5-10H,1,3-4H2,(H2,20,21)
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n/an/a 1.00E+4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM255739
PNG
(US9475815, WO 2007/61737: 4 | US9598416, Example 4...)
Show SMILES Nc1nccn2c(nc(-c3ccc4sccc4c3)c12)C1CCC1
Show InChI InChI=1S/C18H16N4S/c19-17-16-15(13-4-5-14-12(10-13)6-9-23-14)21-18(11-2-1-3-11)22(16)8-7-20-17/h4-11H,1-3H2,(H2,19,20)
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n/an/a 1.20E+4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM255744
PNG
(US9475815, WO 2007/61737: 205 | US9598416, Example...)
Show SMILES COc1cccc2cc(oc12)-c1nc(C2CCC2)n2ccnc(N)c12
Show InChI InChI=1S/C19H18N4O2/c1-24-13-7-3-6-12-10-14(25-17(12)13)15-16-18(20)21-8-9-23(16)19(22-15)11-4-2-5-11/h3,6-11H,2,4-5H2,1H3,(H2,20,21)
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n/an/a 2.00E+4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
Usually, test compounds were tested on the same microtiter plate at 11 different concentrations in the range of 20 μM to 0.1 nM (e.g. 20 μM...


US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM255744
PNG
(US9475815, WO 2007/61737: 205 | US9598416, Example...)
Show SMILES COc1cccc2cc(oc12)-c1nc(C2CCC2)n2ccnc(N)c12
Show InChI InChI=1S/C19H18N4O2/c1-24-13-7-3-6-12-10-14(25-17(12)13)15-16-18(20)21-8-9-23(16)19(22-15)11-4-2-5-11/h3,6-11H,2,4-5H2,1H3,(H2,20,21)
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n/an/a 2.00E+4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH

US Patent




US Patent US9598416 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%