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Patent code US9598440

Compile Data Set for Download or QSAR
Found 159 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302970
PNG
(US9598440, 111)
Show SMILES Cc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)cc(C)n1
Show InChI InChI=1S/C28H32N6O3/c1-15-11-18(12-16(2)30-15)31-27-29-14-19(22-10-9-17-7-5-6-8-21(17)32-22)26(34-27)33-23-13-20(28(3,4)37)24(35)25(23)36/h5-12,14,20,23-25,35-37H,13H2,1-4H3,(H2,29,30,31,33,34)/p+1/t20-,23+,24+,25-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302992
PNG
(US9598440, 133)
Show SMILES Cc1csc(n1)-c1cnc(Nc2cc(C)nc(C)c2)nc1N[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)C(C)(C)O
Show InChI InChI=1S/C23H30N6O3S/c1-11-6-14(7-12(2)25-11)27-22-24-9-15(21-26-13(3)10-33-21)20(29-22)28-17-8-16(23(4,5)32)18(30)19(17)31/h6-7,9-10,16-19,30-32H,8H2,1-5H3,(H2,24,25,27,28,29)/t16-,17+,18+,19-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302972
PNG
(US9598440, 113)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)cc(C)n1
Show InChI InChI=1S/C26H30N6O3S/c1-13-9-15(10-14(2)28-13)29-25-27-12-16(24-31-18-7-5-6-8-20(18)36-24)23(32-25)30-19-11-17(26(3,4)35)21(33)22(19)34/h5-10,12,17,19,21-22,33-35H,11H2,1-4H3,(H2,27,28,29,30,32)/p+1/t17-,19+,21+,22-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302983
PNG
(US9598440, 124)
Show SMILES Cc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)ccn1
Show InChI InChI=1S/C27H30N6O3/c1-15-12-17(10-11-28-15)30-26-29-14-18(21-9-8-16-6-4-5-7-20(16)31-21)25(33-26)32-22-13-19(27(2,3)36)23(34)24(22)35/h4-12,14,19,22-24,34-36H,13H2,1-3H3,(H2,28,29,30,32,33)/p+1/t19-,22+,23+,24-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068540
PNG
(CHEMBL3403457 | US9598440, 68)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccncc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C23H25N7O3S/c1-11-5-14(6-12(2)26-11)27-23-25-8-15(22-29-16-3-4-24-9-18(16)34-22)21(30-23)28-17-7-13(10-31)19(32)20(17)33/h3-6,8-9,13,17,19-20,31-33H,7,10H2,1-2H3,(H2,25,26,27,28,30)/t13-,17-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302996
PNG
(US9598440, 137)
Show SMILES Cc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)cc(C)n1
Show InChI InChI=1S/C25H29N7O3S/c1-12-7-14(8-13(2)28-12)29-24-27-10-15(23-31-18-11-26-6-5-19(18)36-23)22(32-24)30-17-9-16(25(3,4)35)20(33)21(17)34/h5-8,10-11,16-17,20-21,33-35H,9H2,1-4H3,(H2,27,28,29,30,32)/p+1/t16-,17+,20+,21-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068538
PNG
(CHEMBL3403455 | US9598440, 9)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C24H26N6O3S/c1-12-7-15(8-13(2)26-12)27-24-25-10-16(23-29-17-5-3-4-6-19(17)34-23)22(30-24)28-18-9-14(11-31)20(32)21(18)33/h3-8,10,14,18,20-21,31-33H,9,11H2,1-2H3,(H2,25,26,27,28,30)/t14-,18-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302929
PNG
(US9598440, 67)
Show SMILES Cc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C23H25N7O3S/c1-11-5-14(6-12(2)26-11)27-23-25-8-15(22-29-17-9-24-4-3-18(17)34-22)21(30-23)28-16-7-13(10-31)19(32)20(16)33/h3-6,8-9,13,16,19-20,31-33H,7,10H2,1-2H3,(H2,25,26,27,28,30)/t13-,16-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302997
PNG
(US9598440, 138)
Show SMILES Cc1cc(Nc2ncc(-c3nc4c(C)nccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)cc(C)n1
Show InChI InChI=1S/C26H31N7O3S/c1-12-8-15(9-13(2)29-12)30-25-28-11-16(24-32-20-14(3)27-7-6-19(20)37-24)23(33-25)31-18-10-17(26(4,5)36)21(34)22(18)35/h6-9,11,17-18,21-22,34-36H,10H2,1-5H3,(H2,28,29,30,31,33)/p+1/t17-,18+,21+,22-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302995
PNG
(US9598440, 136)
Show SMILES COc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)ccn1
Show InChI InChI=1S/C24H27N7O4S/c1-24(2,34)14-9-15(20(33)19(14)32)29-21-13(22-30-16-11-25-6-5-17(16)36-22)10-27-23(31-21)28-12-4-7-26-18(8-12)35-3/h4-8,10-11,14-15,19-20,32-34H,9H2,1-3H3,(H2,26,27,28,29,31)/p+1/t14-,15+,19+,20-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302994
PNG
(US9598440, 135)
Show SMILES COc1cc(Nc2ncc(-c3nc(C)cs3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)n2)ccn1
Show InChI InChI=1S/C22H28N6O4S/c1-11-10-33-20(25-11)13-9-24-21(26-12-5-6-23-16(7-12)32-4)28-19(13)27-15-8-14(22(2,3)31)17(29)18(15)30/h5-7,9-10,14-15,17-18,29-31H,8H2,1-4H3,(H2,23,24,26,27,28)/t14-,15+,17+,18-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302921
PNG
(US9598440, 59)
Show SMILES Cc1cc(Nc2ncc(-c3ccc4ccccc4n3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)cc(C)n1
Show InChI InChI=1S/C26H28N6O3/c1-14-9-18(10-15(2)28-14)29-26-27-12-19(21-8-7-16-5-3-4-6-20(16)30-21)25(32-26)31-22-11-17(13-33)23(34)24(22)35/h3-10,12,17,22-24,33-35H,11,13H2,1-2H3,(H2,27,28,29,31,32)/p+1/t17-,22-,23-,24+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068461
PNG
(CHEMBL3403439 | US9598440, 83)
Show SMILES Nc1ncc(-c2nc3cccnc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C16H18N6O3S/c17-16-19-5-8(14-21-9-2-1-3-18-15(9)26-14)13(22-16)20-10-4-7(6-23)11(24)12(10)25/h1-3,5,7,10-12,23-25H,4,6H2,(H3,17,19,20,22)/t7-,10-,11-,12+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068537
PNG
(CHEMBL3403454 | US9598440, 31)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
Show InChI InChI=1S/C23H24N6O3S/c1-12-8-14(6-7-24-12)26-23-25-10-15(22-28-16-4-2-3-5-18(16)33-22)21(29-23)27-17-9-13(11-30)19(31)20(17)32/h2-8,10,13,17,19-20,30-32H,9,11H2,1H3,(H2,24,25,26,27,29)/t13-,17-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302988
PNG
(US9598440, 129)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2nc(Nc3cccc(c3)C(N)=O)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C26H28N6O4S/c1-26(2,36)16-11-18(21(34)20(16)33)30-23-15(24-31-17-8-3-4-9-19(17)37-24)12-28-25(32-23)29-14-7-5-6-13(10-14)22(27)35/h3-10,12,16,18,20-21,33-34,36H,11H2,1-2H3,(H2,27,35)(H2,28,29,30,32)/t16-,18+,20+,21-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302937
PNG
(US9598440, 75)
Show SMILES COc1cc(Nc2ncc(-c3nc4ccncc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)ccn1
Show InChI InChI=1S/C22H23N7O4S/c1-33-17-7-12(2-5-24-17)26-22-25-8-13(21-28-14-3-4-23-9-16(14)34-21)20(29-22)27-15-6-11(10-30)18(31)19(15)32/h2-5,7-9,11,15,18-19,30-32H,6,10H2,1H3,(H2,24,25,26,27,29)/p+1/t11-,15-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303007
PNG
(US9598440, 148)
Show SMILES CO[C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)OC)Nc1nc(Nc2cc(C)nc(C)c2)ncc1-c1nc2ccccc2s1
Show InChI InChI=1S/C26H28N6O4S/c1-13-9-15(10-14(2)28-13)29-26-27-12-17(24-31-18-7-5-6-8-20(18)37-24)23(32-26)30-19-11-16(25(34)36-4)21(33)22(19)35-3/h5-10,12,16,19,21-22,33H,11H2,1-4H3,(H2,27,28,29,30,32)/t16-,19+,21+,22-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303008
PNG
(US9598440, 149)
Show SMILES CO[C@H]1[C@@H](C[C@@H]([C@H]1O)C(C)(C)O)Nc1nc(Nc2cc(C)nc(C)c2)ncc1-c1nc2ccccc2s1
Show InChI InChI=1S/C27H32N6O3S/c1-14-10-16(11-15(2)29-14)30-26-28-13-17(25-32-19-8-6-7-9-21(19)37-25)24(33-26)31-20-12-18(27(3,4)35)22(34)23(20)36-5/h6-11,13,18,20,22-23,34-35H,12H2,1-5H3,(H2,28,29,30,31,33)/t18-,20+,22+,23-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302907
PNG
(US9598440, 45)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
Show InChI InChI=1S/C28H33N7O3S/c1-34-9-11-35(12-10-34)19-6-4-5-18(14-19)30-28-29-15-20(27-32-21-7-2-3-8-23(21)39-27)26(33-28)31-22-13-17(16-36)24(37)25(22)38/h2-8,14-15,17,22,24-25,36-38H,9-13,16H2,1H3,(H2,29,30,31,33)/t17-,22-,24-,25+/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302906
PNG
(US9598440, 44)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1
Show InChI InChI=1S/C28H33N7O3S/c1-34-10-12-35(13-11-34)19-8-6-18(7-9-19)30-28-29-15-20(27-32-21-4-2-3-5-23(21)39-27)26(33-28)31-22-14-17(16-36)24(37)25(22)38/h2-9,15,17,22,24-25,36-38H,10-14,16H2,1H3,(H2,29,30,31,33)/t17-,22-,24-,25+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303022
PNG
(US9598440, 164)
Show SMILES Cc1cc(Nc2cc(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)c(cn2)-c2ccc3ccccc3n2)cc(C)n1
Show InChI InChI=1S/C29H33N5O3/c1-16-11-19(12-17(2)31-16)32-26-14-24(34-25-13-21(29(3,4)37)27(35)28(25)36)20(15-30-26)23-10-9-18-7-5-6-8-22(18)33-23/h5-12,14-15,21,25,27-28,35-37H,13H2,1-4H3,(H2,30,31,32,34)/t21-,25+,27+,28-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50108087
PNG
(CHEMBL3601071 | US9598440, 69)
Show SMILES Cc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
Show InChI InChI=1S/C22H23N7O3S/c1-11-6-13(2-5-24-11)26-22-25-8-14(21-28-16-9-23-4-3-17(16)33-21)20(29-22)27-15-7-12(10-30)18(31)19(15)32/h2-6,8-9,12,15,18-19,30-32H,7,10H2,1H3,(H2,24,25,26,27,29)/t12-,15-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303003
PNG
(US9598440, 144)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CF)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C24H25FN6O2S/c1-12-7-15(8-13(2)27-12)28-24-26-11-16(23-30-17-5-3-4-6-19(17)34-23)22(31-24)29-18-9-14(10-25)20(32)21(18)33/h3-8,11,14,18,20-21,32-33H,9-10H2,1-2H3,(H2,26,27,28,29,31)/t14-,18-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302973
PNG
(US9598440, 114)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2[nH+]c(Nc3ccnc(c3)C#N)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25N7O3S/c1-25(2,35)16-10-18(21(34)20(16)33)30-22-15(23-31-17-5-3-4-6-19(17)36-23)12-28-24(32-22)29-13-7-8-27-14(9-13)11-26/h3-9,12,16,18,20-21,33-35H,10H2,1-2H3,(H2,27,28,29,30,32)/p+1/t16-,18+,20+,21-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302932
PNG
(US9598440, 70)
Show SMILES Cc1cc([NH2+]c2ncc(-c3nc(cs3)-c3ccccc3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C26H28N6O3S/c1-14-8-18(9-15(2)28-14)29-26-27-11-19(25-31-21(13-36-25)16-6-4-3-5-7-16)24(32-26)30-20-10-17(12-33)22(34)23(20)35/h3-9,11,13,17,20,22-23,33-35H,10,12H2,1-2H3,(H2,27,28,29,30,32)/p+1/t17-,20-,22-,23+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302971
PNG
(US9598440, 112)
Show SMILES COc1cc(Nc2ncc(c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)-c2ccc3ccccc3n2)ccn1
Show InChI InChI=1S/C27H30N6O4/c1-27(2,36)18-13-21(24(35)23(18)34)32-25-17(20-9-8-15-6-4-5-7-19(15)31-20)14-29-26(33-25)30-16-10-11-28-22(12-16)37-3/h4-12,14,18,21,23-24,34-36H,13H2,1-3H3,(H2,28,29,30,32,33)/p+1/t18-,21+,23+,24-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50108086
PNG
(CHEMBL3601072 | US9598440, 66)
Show SMILES CN(C)c1ccc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1
Show InChI InChI=1S/C24H27N7O3S/c1-31(2)15-5-3-14(4-6-15)27-24-26-10-16(23-29-18-11-25-8-7-19(18)35-23)22(30-24)28-17-9-13(12-32)20(33)21(17)34/h3-8,10-11,13,17,20-21,32-34H,9,12H2,1-2H3,(H2,26,27,28,30)/t13-,17-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302869
PNG
(US9598440, 7)
Show SMILES COc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
Show InChI InChI=1S/C23H24N6O4S/c1-33-18-9-13(6-7-24-18)26-23-25-10-14(22-28-15-4-2-3-5-17(15)34-22)21(29-23)27-16-8-12(11-30)19(31)20(16)32/h2-7,9-10,12,16,19-20,30-32H,8,11H2,1H3,(H2,24,25,26,27,29)/t12-,16-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068539
PNG
(CHEMBL3403456 | US9598440, 26)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3cncnc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C21H21N7O3S/c29-9-11-5-15(18(31)17(11)30)26-19-13(20-27-14-3-1-2-4-16(14)32-20)8-24-21(28-19)25-12-6-22-10-23-7-12/h1-4,6-8,10-11,15,17-18,29-31H,5,9H2,(H2,24,25,26,28)/t11-,15-,17-,18+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302890
PNG
(US9598440, 27)
Show SMILES NC(=O)c1cccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
Show InChI InChI=1S/C24H24N6O4S/c25-21(34)12-4-3-5-14(8-12)27-24-26-10-15(23-29-16-6-1-2-7-18(16)35-23)22(30-24)28-17-9-13(11-31)19(32)20(17)33/h1-8,10,13,17,19-20,31-33H,9,11H2,(H2,25,34)(H2,26,27,28,30)/t13-,17-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302877
PNG
(US9598440, 14)
Show SMILES NC(=O)Cc1cccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
Show InChI InChI=1S/C25H26N6O4S/c26-20(33)9-13-4-3-5-15(8-13)28-25-27-11-16(24-30-17-6-1-2-7-19(17)36-24)23(31-25)29-18-10-14(12-32)21(34)22(18)35/h1-8,11,14,18,21-22,32,34-35H,9-10,12H2,(H2,26,33)(H2,27,28,29,31)/t14-,18-,21-,22+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302864
PNG
(US9598440, 2)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccc(O)cc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H23N5O4S/c29-11-12-9-17(20(32)19(12)31)26-21-15(22-27-16-3-1-2-4-18(16)33-22)10-24-23(28-21)25-13-5-7-14(30)8-6-13/h1-8,10,12,17,19-20,29-32H,9,11H2,(H2,24,25,26,28)/t12-,17-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303017
PNG
(US9598440, 159)
Show SMILES Cc1cc(Nc2cc(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)c(cn2)-c2nc3ccccc3s2)cc(C)n1
Show InChI InChI=1S/C27H31N5O3S/c1-14-9-16(10-15(2)29-14)30-23-12-20(31-21-11-18(27(3,4)35)24(33)25(21)34)17(13-28-23)26-32-19-7-5-6-8-22(19)36-26/h5-10,12-13,18,21,24-25,33-35H,11H2,1-4H3,(H2,28,29,30,31)/t18-,21+,24+,25-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302936
PNG
(US9598440, 74)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(Nc3cncnc3)ncc2-c2nc3ccncc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C20H20N8O3S/c29-8-10-3-14(17(31)16(10)30)26-18-12(19-27-13-1-2-21-7-15(13)32-19)6-24-20(28-18)25-11-4-22-9-23-5-11/h1-2,4-7,9-10,14,16-17,29-31H,3,8H2,(H2,24,25,26,28)/p+1/t10-,14-,16-,17+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302912
PNG
(US9598440, 50)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccc4[nH]ncc4c3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C24H23N7O3S/c32-11-13-8-18(21(34)20(13)33)28-22-15(23-29-17-3-1-2-4-19(17)35-23)10-25-24(30-22)27-14-5-6-16-12(7-14)9-26-31-16/h1-7,9-10,13,18,20-21,32-34H,8,11H2,(H,26,31)(H2,25,27,28,30)/t13-,18-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302933
PNG
(US9598440, 71)
Show SMILES COc1cc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)ccn1
Show InChI InChI=1S/C22H23N7O4S/c1-33-17-7-12(2-5-24-17)26-22-25-8-13(21-28-15-9-23-4-3-16(15)34-21)20(29-22)27-14-6-11(10-30)18(31)19(14)32/h2-5,7-9,11,14,18-19,30-32H,6,10H2,1H3,(H2,24,25,26,27,29)/p+1/t11-,14-,18-,19+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068534
PNG
(CHEMBL3403451 | US9598440, 18)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCCCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H29N5O3S/c29-12-13-10-17(20(31)19(13)30)26-21-15(22-27-16-8-4-5-9-18(16)32-22)11-24-23(28-21)25-14-6-2-1-3-7-14/h4-5,8-9,11,13-14,17,19-20,29-31H,1-3,6-7,10,12H2,(H2,24,25,26,28)/t13-,17-,19-,20+/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50108016
PNG
(CHEMBL3601083 | US9598440, 41)
Show SMILES Cc1cc(Nc2ncc(-c3cscn3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C20H24N6O3S/c1-10-3-13(4-11(2)23-10)24-20-21-6-14(16-8-30-9-22-16)19(26-20)25-15-5-12(7-27)17(28)18(15)29/h3-4,6,8-9,12,15,17-18,27-29H,5,7H2,1-2H3,(H2,21,23,24,25,26)/t12-,15-,17-,18+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302920
PNG
(US9598440, 58)
Show SMILES COc1cc(Nc2ncc(c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)-c2ccc3ccccc3n2)ccn1
Show InChI InChI=1S/C25H26N6O4/c1-35-21-11-16(8-9-26-21)28-25-27-12-17(19-7-6-14-4-2-3-5-18(14)29-19)24(31-25)30-20-10-15(13-32)22(33)23(20)34/h2-9,11-12,15,20,22-23,32-34H,10,13H2,1H3,(H2,26,27,28,30,31)/p+1/t15-,20-,22-,23+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302968
PNG
(US9598440, 107)
Show SMILES Cc1cc(Nc2nc(C)c(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)cc(C)n1
Show InChI InChI=1S/C27H32N6O3S/c1-13-10-16(11-14(2)28-13)30-26-29-15(3)21(25-32-18-8-6-7-9-20(18)37-25)24(33-26)31-19-12-17(27(4,5)36)22(34)23(19)35/h6-11,17,19,22-23,34-36H,12H2,1-5H3,(H2,28,29,30,31,33)/p+1/t17-,19+,22+,23-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302941
PNG
(US9598440, 79)
Show SMILES Cc1cc(Nc2ncc(-c3nc(cs3)-c3ccccc3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)ccn1
Show InChI InChI=1S/C25H26N6O3S/c1-14-9-17(7-8-26-14)28-25-27-11-18(24-30-20(13-35-24)15-5-3-2-4-6-15)23(31-25)29-19-10-16(12-32)21(33)22(19)34/h2-9,11,13,16,19,21-22,32-34H,10,12H2,1H3,(H2,26,27,28,29,31)/p+1/t16-,19-,21-,22+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302939
PNG
(US9598440, 77)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccncc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)ccn1
Show InChI InChI=1S/C22H23N7O3S/c1-11-6-13(2-5-24-11)26-22-25-8-14(21-28-15-3-4-23-9-17(15)33-21)20(29-22)27-16-7-12(10-30)18(31)19(16)32/h2-6,8-9,12,16,18-19,30-32H,7,10H2,1H3,(H2,24,25,26,27,29)/p+1/t12-,16-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302905
PNG
(US9598440, 43)
Show SMILES COc1ccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cn1
Show InChI InChI=1S/C23H24N6O4S/c1-33-18-7-6-13(9-24-18)26-23-25-10-14(22-28-15-4-2-3-5-17(15)34-22)21(29-23)27-16-8-12(11-30)19(31)20(16)32/h2-7,9-10,12,16,19-20,30-32H,8,11H2,1H3,(H2,25,26,27,29)/t12-,16-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302901
PNG
(US9598440, 39)
Show SMILES CN(C)c1cccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
Show InChI InChI=1S/C25H28N6O3S/c1-31(2)16-7-5-6-15(11-16)27-25-26-12-17(24-29-18-8-3-4-9-20(18)35-24)23(30-25)28-19-10-14(13-32)21(33)22(19)34/h3-9,11-12,14,19,21-22,32-34H,10,13H2,1-2H3,(H2,26,27,28,30)/t14-,19-,21-,22+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302999
PNG
(US9598440, 140)
Show SMILES CO[C@H]1[C@@H](C[C@H](CO)[C@H]1O)Nc1nc(Nc2cc(C)nc(C)c2)ncc1-c1nc2ccccc2s1
Show InChI InChI=1S/C25H28N6O3S/c1-13-8-16(9-14(2)27-13)28-25-26-11-17(24-30-18-6-4-5-7-20(18)35-24)23(31-25)29-19-10-15(12-32)21(33)22(19)34-3/h4-9,11,15,19,21-22,32-33H,10,12H2,1-3H3,(H2,26,27,28,29,31)/t15-,19-,21-,22+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302985
PNG
(US9598440, 126)
Show SMILES COc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)ccn1
Show InChI InChI=1S/C25H28N6O4S/c1-25(2,34)15-11-17(21(33)20(15)32)29-22-14(23-30-16-6-4-5-7-18(16)36-23)12-27-24(31-22)28-13-8-9-26-19(10-13)35-3/h4-10,12,15,17,20-21,32-34H,11H2,1-3H3,(H2,26,27,28,29,31)/p+1/t15-,17+,20+,21-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302899
PNG
(US9598440, 37)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3cccnc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H22N6O3S/c29-11-12-8-16(19(31)18(12)30)26-20-14(21-27-15-5-1-2-6-17(15)32-21)10-24-22(28-20)25-13-4-3-7-23-9-13/h1-7,9-10,12,16,18-19,29-31H,8,11H2,(H2,24,25,26,28)/t12-,16-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302897
PNG
(US9598440, 35)
Show SMILES Cc1cc(C)cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
Show InChI InChI=1S/C25H27N5O3S/c1-13-7-14(2)9-16(8-13)27-25-26-11-17(24-29-18-5-3-4-6-20(18)34-24)23(30-25)28-19-10-15(12-31)21(32)22(19)33/h3-9,11,15,19,21-22,31-33H,10,12H2,1-2H3,(H2,26,27,28,30)/t15-,19-,21-,22+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302979
PNG
(US9598440, 120)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2[nH+]c(Nc3ccnc(c3)C(F)(F)F)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25F3N6O3S/c1-24(2,37)14-10-16(20(36)19(14)35)32-21-13(22-33-15-5-3-4-6-17(15)38-22)11-30-23(34-21)31-12-7-8-29-18(9-12)25(26,27)28/h3-9,11,14,16,19-20,35-37H,10H2,1-2H3,(H2,29,30,31,32,34)/p+1/t14-,16+,19+,20-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302891
PNG
(US9598440, 29)
Show SMILES NC(=O)Cc1ccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1
Show InChI InChI=1S/C25H26N6O4S/c26-20(33)9-13-5-7-15(8-6-13)28-25-27-11-16(24-30-17-3-1-2-4-19(17)36-24)23(31-25)29-18-10-14(12-32)21(34)22(18)35/h1-8,11,14,18,21-22,32,34-35H,9-10,12H2,(H2,26,33)(H2,27,28,29,31)/t14-,18-,21-,22+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302865
PNG
(US9598440, 3)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3cccc(O)c3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H23N5O4S/c29-11-12-8-17(20(32)19(12)31)26-21-15(22-27-16-6-1-2-7-18(16)33-22)10-24-23(28-21)25-13-4-3-5-14(30)9-13/h1-7,9-10,12,17,19-20,29-32H,8,11H2,(H2,24,25,26,28)/t12-,17-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302935
PNG
(US9598440, 73)
Show SMILES CN(C)c1cccc(Nc2ncc(-c3nc4cnccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)c1
Show InChI InChI=1S/C24H27N7O3S/c1-31(2)15-5-3-4-14(9-15)27-24-26-10-16(23-29-18-11-25-7-6-19(18)35-23)22(30-24)28-17-8-13(12-32)20(33)21(17)34/h3-7,9-11,13,17,20-21,32-34H,8,12H2,1-2H3,(H2,26,27,28,30)/p+1/t13-,17-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302896
PNG
(US9598440, 34)
Show SMILES CN(C)c1ccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1
Show InChI InChI=1S/C25H28N6O3S/c1-31(2)16-9-7-15(8-10-16)27-25-26-12-17(24-29-18-5-3-4-6-20(18)35-24)23(30-25)28-19-11-14(13-32)21(33)22(19)34/h3-10,12,14,19,21-22,32-34H,11,13H2,1-2H3,(H2,26,27,28,30)/t14-,19-,21-,22+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302917
PNG
(US9598440, 55)
Show SMILES OC[C@H]1CC(Nc2nc([NH2+]c3cccnc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H22N6O3S/c29-11-12-8-16(19(31)18(12)30)26-20-14(21-27-15-5-1-2-6-17(15)32-21)10-24-22(28-20)25-13-4-3-7-23-9-13/h1-7,9-10,12,16,18-19,29-31H,8,11H2,(H2,24,25,26,28)/p+1/t12-,16?,18-,19+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302934
PNG
(US9598440, 72)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(Nc3cncnc3)ncc2-c2nc3cnccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C20H20N8O3S/c29-8-10-3-13(17(31)16(10)30)26-18-12(19-27-14-7-21-2-1-15(14)32-19)6-24-20(28-18)25-11-4-22-9-23-5-11/h1-2,4-7,9-10,13,16-17,29-31H,3,8H2,(H2,24,25,26,28)/p+1/t10-,13-,16-,17+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302940
PNG
(US9598440, 78)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(Nc3cccnc3)ncc2-c2nc3ccncc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C21H21N7O3S/c29-10-11-6-15(18(31)17(11)30)26-19-13(20-27-14-3-5-23-9-16(14)32-20)8-24-21(28-19)25-12-2-1-4-22-7-12/h1-5,7-9,11,15,17-18,29-31H,6,10H2,(H2,24,25,26,28)/p+1/t11-,15-,17-,18+/m1/s1
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n/an/a 13n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50107852
PNG
(CHEMBL3601196 | US9598440, 154)
Show SMILES Cc1cc(Nc2cc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(cn2)-c2nc3ccccc3s2)cc(C)n1
Show InChI InChI=1S/C25H27N5O3S/c1-13-7-16(8-14(2)27-13)28-22-10-19(29-20-9-15(12-31)23(32)24(20)33)17(11-26-22)25-30-18-5-3-4-6-21(18)34-25/h3-8,10-11,15,20,23-24,31-33H,9,12H2,1-2H3,(H2,26,27,28,29)/t15-,20-,23-,24+/m1/s1
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n/an/a 13n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302873
PNG
(US9598440, 10)
Show SMILES COc1ccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc1
Show InChI InChI=1S/C24H25N5O4S/c1-33-15-8-6-14(7-9-15)26-24-25-11-16(23-28-17-4-2-3-5-19(17)34-23)22(29-24)27-18-10-13(12-30)20(31)21(18)32/h2-9,11,13,18,20-21,30-32H,10,12H2,1H3,(H2,25,26,27,29)/t13-,18-,20-,21+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302978
PNG
(US9598440, 119)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2[nH+]c(Nc3ccccc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C25H27N5O3S/c1-25(2,33)16-12-18(21(32)20(16)31)28-22-15(23-29-17-10-6-7-11-19(17)34-23)13-26-24(30-22)27-14-8-4-3-5-9-14/h3-11,13,16,18,20-21,31-33H,12H2,1-2H3,(H2,26,27,28,30)/p+1/t16-,18+,20+,21-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068462
PNG
(CHEMBL3403440 | US9598440, 21)
Show SMILES Nc1ncc(-c2nc3ccncc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C16H18N6O3S/c17-16-19-4-8(15-21-9-1-2-18-5-11(9)26-15)14(22-16)20-10-3-7(6-23)12(24)13(10)25/h1-2,4-5,7,10,12-13,23-25H,3,6H2,(H3,17,19,20,22)/t7-,10-,12-,13+/m1/s1
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n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302986
PNG
(US9598440, 127)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)n2)ccn1
Show InChI InChI=1S/C25H28N6O3S/c1-13-10-14(8-9-26-13)28-24-27-12-15(23-30-17-6-4-5-7-19(17)35-23)22(31-24)29-18-11-16(25(2,3)34)20(32)21(18)33/h4-10,12,16,18,20-21,32-34H,11H2,1-3H3,(H2,26,27,28,29,31)/t16-,18+,20+,21-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302977
PNG
(US9598440, 118)
Show SMILES Cc1cccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)c1
Show InChI InChI=1S/C26H29N5O3S/c1-14-7-6-8-15(11-14)28-25-27-13-16(24-30-18-9-4-5-10-20(18)35-24)23(31-25)29-19-12-17(26(2,3)34)21(32)22(19)33/h4-11,13,17,19,21-22,32-34H,12H2,1-3H3,(H2,27,28,29,31)/p+1/t17-,19+,21+,22-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302952
PNG
(US9598440, 90)
Show SMILES Cc1nc(NC2CC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C21H25N5O3S/c1-10-16(20-25-13-4-2-3-5-15(13)30-20)19(26-21(22-10)23-12-6-7-12)24-14-8-11(9-27)17(28)18(14)29/h2-5,11-12,14,17-18,27-29H,6-9H2,1H3,(H2,22,23,24,26)/t11-,14-,17-,18+/m1/s1
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n/an/a 17.5n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302975
PNG
(US9598440, 116)
Show SMILES CC(C)Oc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)ccn1
Show InChI InChI=1S/C27H32N6O4S/c1-14(2)37-21-11-15(9-10-28-21)30-26-29-13-16(25-32-18-7-5-6-8-20(18)38-25)24(33-26)31-19-12-17(27(3,4)36)22(34)23(19)35/h5-11,13-14,17,19,22-23,34-36H,12H2,1-4H3,(H2,28,29,30,31,33)/p+1/t17-,19+,22+,23-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303021
PNG
(US9598440, 163)
Show SMILES COc1cc(Nc2cc(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)c(cn2)-c2ccc3ccccc3n2)ccn1
Show InChI InChI=1S/C28H31N5O4/c1-28(2,36)19-13-23(27(35)26(19)34)33-22-14-24(31-17-10-11-29-25(12-17)37-3)30-15-18(22)21-9-8-16-6-4-5-7-20(16)32-21/h4-12,14-15,19,23,26-27,34-36H,13H2,1-3H3,(H2,29,30,31,33)/t19-,23+,26+,27-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302976
PNG
(US9598440, 117)
Show SMILES COc1cccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)c1
Show InChI InChI=1S/C26H29N5O4S/c1-26(2,34)17-12-19(22(33)21(17)32)29-23-16(24-30-18-9-4-5-10-20(18)36-24)13-27-25(31-23)28-14-7-6-8-15(11-14)35-3/h4-11,13,17,19,21-22,32-34H,12H2,1-3H3,(H2,27,28,29,31)/p+1/t17-,19+,21+,22-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068536
PNG
(CHEMBL3403453 | US9598440, 1)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccccc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H23N5O3S/c29-12-13-10-17(20(31)19(13)30)26-21-15(22-27-16-8-4-5-9-18(16)32-22)11-24-23(28-21)25-14-6-2-1-3-7-14/h1-9,11,13,17,19-20,29-31H,10,12H2,(H2,24,25,26,28)/t13-,17-,19-,20+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302886
PNG
(US9598440, 23)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccc4[nH]ccc4c3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C25H24N6O3S/c32-12-14-10-19(22(34)21(14)33)29-23-16(24-30-18-3-1-2-4-20(18)35-24)11-27-25(31-23)28-15-5-6-17-13(9-15)7-8-26-17/h1-9,11,14,19,21-22,26,32-34H,10,12H2,(H2,27,28,29,31)/t14-,19-,21-,22+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302887
PNG
(US9598440, 24)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccc4cc[nH]c4c3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C25H24N6O3S/c32-12-14-9-19(22(34)21(14)33)29-23-16(24-30-17-3-1-2-4-20(17)35-24)11-27-25(31-23)28-15-6-5-13-7-8-26-18(13)10-15/h1-8,10-11,14,19,21-22,26,32-34H,9,12H2,(H2,27,28,29,31)/t14-,19-,21-,22+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302989
PNG
(US9598440, 130)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2nc(N)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C19H23N5O3S/c1-19(2,27)10-7-12(15(26)14(10)25)22-16-9(8-21-18(20)24-16)17-23-11-5-3-4-6-13(11)28-17/h3-6,8,10,12,14-15,25-27H,7H2,1-2H3,(H3,20,21,22,24)/t10-,12+,14+,15-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068463
PNG
(CHEMBL3403441 | US9598440, 20)
Show SMILES Nc1ncc(-c2nc3cnccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C16H18N6O3S/c17-16-19-4-8(15-21-10-5-18-2-1-11(10)26-15)14(22-16)20-9-3-7(6-23)12(24)13(9)25/h1-2,4-5,7,9,12-13,23-25H,3,6H2,(H3,17,19,20,22)/t7-,9-,12-,13+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302923
PNG
(US9598440, 61)
Show SMILES CC(C)Oc1cc(Nc2ncc(c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)-c2ccc3ccccc3n2)ccn1
Show InChI InChI=1S/C27H30N6O4/c1-15(2)37-23-12-18(9-10-28-23)30-27-29-13-19(21-8-7-16-5-3-4-6-20(16)31-21)26(33-27)32-22-11-17(14-34)24(35)25(22)36/h3-10,12-13,15,17,22,24-25,34-36H,11,14H2,1-2H3,(H2,28,29,30,32,33)/p+1/t17-,22-,24-,25+/m1/s1
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n/an/a 27n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302998
PNG
(US9598440, 139)
Show SMILES CO[C@H]1[C@@H](C[C@H](CO)[C@H]1O)Nc1nc(Nc2ccnc(OC)c2)ncc1-c1nc2ccccc2s1
Show InChI InChI=1S/C24H26N6O4S/c1-33-19-10-14(7-8-25-19)27-24-26-11-15(23-29-16-5-3-4-6-18(16)35-23)22(30-24)28-17-9-13(12-31)20(32)21(17)34-2/h3-8,10-11,13,17,20-21,31-32H,9,12H2,1-2H3,(H2,25,26,27,28,30)/t13-,17-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303000
PNG
(US9598440, 141)
Show SMILES CO[C@H]1[C@@H](C[C@H](CO)[C@H]1O)Nc1nc(Nc2ccnc(OC)c2)ncc1-c1ccc2ccccc2n1
Show InChI InChI=1S/C26H28N6O4/c1-35-22-12-17(9-10-27-22)29-26-28-13-18(20-8-7-15-5-3-4-6-19(15)30-20)25(32-26)31-21-11-16(14-33)23(34)24(21)36-2/h3-10,12-13,16,21,23-24,33-34H,11,14H2,1-2H3,(H2,27,28,29,31,32)/t16-,21-,23-,24+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302888
PNG
(US9598440, 25)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccncn3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C21H21N7O3S/c29-9-11-7-14(18(31)17(11)30)25-19-12(20-26-13-3-1-2-4-15(13)32-20)8-23-21(28-19)27-16-5-6-22-10-24-16/h1-6,8,10-11,14,17-18,29-31H,7,9H2,(H2,22,23,24,25,27,28)/t11-,14-,17-,18+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302957
PNG
(US9598440, 96)
Show SMILES Cc1csc(n1)-c1c(C)nc(N)nc1N[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H21N5O3S/c1-6-5-24-14(17-6)10-7(2)18-15(16)20-13(10)19-9-3-8(4-21)11(22)12(9)23/h5,8-9,11-12,21-23H,3-4H2,1-2H3,(H3,16,18,19,20)/t8-,9-,11-,12+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302974
PNG
(US9598440, 115)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2[nH+]c(Nc3cccc(c3)C#N)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C26H26N6O3S/c1-26(2,35)17-11-19(22(34)21(17)33)30-23-16(24-31-18-8-3-4-9-20(18)36-24)13-28-25(32-23)29-15-7-5-6-14(10-15)12-27/h3-10,13,17,19,21-22,33-35H,11H2,1-2H3,(H2,28,29,30,32)/p+1/t17-,19+,21+,22-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303020
PNG
(US9598440, 162)
Show SMILES Cc1csc(n1)-c1cnc(Nc2cc(C)nc(C)c2)cc1N[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)C(C)(C)O
Show InChI InChI=1S/C24H31N5O3S/c1-12-6-15(7-13(2)26-12)28-20-9-18(16(10-25-20)23-27-14(3)11-33-23)29-19-8-17(24(4,5)32)21(30)22(19)31/h6-7,9-11,17,19,21-22,30-32H,8H2,1-5H3,(H2,25,26,28,29)/t17-,19+,21+,22-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068535
PNG
(CHEMBL3403452 | US9598440, 17)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCOCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H27N5O4S/c28-11-12-9-16(19(30)18(12)29)25-20-14(21-26-15-3-1-2-4-17(15)32-21)10-23-22(27-20)24-13-5-7-31-8-6-13/h1-4,10,12-13,16,18-19,28-30H,5-9,11H2,(H2,23,24,25,27)/t12-,16-,18-,19+/m1/s1
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US Patent
n/an/a 41n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302925
PNG
(US9598440, 63)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(Nc3ccnc(OC4CC4)c3)ncc2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C27H28N6O4/c34-14-16-11-22(25(36)24(16)35)32-26-19(21-8-5-15-3-1-2-4-20(15)31-21)13-29-27(33-26)30-17-9-10-28-23(12-17)37-18-6-7-18/h1-5,8-10,12-13,16,18,22,24-25,34-36H,6-7,11,14H2,(H2,28,29,30,32,33)/p+1/t16-,22-,24-,25+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302892
PNG
(US9598440, 30)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccncc3F)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H21FN6O3S/c23-13-9-24-6-5-14(13)28-22-25-8-12(21-27-15-3-1-2-4-17(15)33-21)20(29-22)26-16-7-11(10-30)18(31)19(16)32/h1-6,8-9,11,16,18-19,30-32H,7,10H2,(H2,24,25,26,28,29)/t11-,16-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302951
PNG
(US9598440, 89)
Show SMILES CN1CCN(CCCNc2nc(C)c(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)CC1
Show InChI InChI=1S/C26H37N7O3S/c1-16-21(25-30-18-6-3-4-7-20(18)37-25)24(29-19-14-17(15-34)22(35)23(19)36)31-26(28-16)27-8-5-9-33-12-10-32(2)11-13-33/h3-4,6-7,17,19,22-23,34-36H,5,8-15H2,1-2H3,(H2,27,28,29,31)/t17-,19-,22-,23+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302987
PNG
(US9598440, 128)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2nc(NC3CCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H29N5O3S/c1-23(2,31)14-10-16(19(30)18(14)29)26-20-13(11-24-22(28-20)25-12-6-5-7-12)21-27-15-8-3-4-9-17(15)32-21/h3-4,8-9,11-12,14,16,18-19,29-31H,5-7,10H2,1-2H3,(H2,24,25,26,28)/t14-,16+,18+,19-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302991
PNG
(US9598440, 132)
Show SMILES Cc1csc(n1)-c1cnc(N)nc1N[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)C(C)(C)O
Show InChI InChI=1S/C16H23N5O3S/c1-7-6-25-14(19-7)8-5-18-15(17)21-13(8)20-10-4-9(16(2,3)24)11(22)12(10)23/h5-6,9-12,22-24H,4H2,1-3H3,(H3,17,18,20,21)/t9-,10+,11+,12-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302954
PNG
(US9598440, 93)
Show SMILES Cc1nc(NCC2CCNCC2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C24H32N6O3S/c1-13-19(23-29-16-4-2-3-5-18(16)34-23)22(28-17-10-15(12-31)20(32)21(17)33)30-24(27-13)26-11-14-6-8-25-9-7-14/h2-5,14-15,17,20-21,25,31-33H,6-12H2,1H3,(H2,26,27,28,30)/t15-,17-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302984
PNG
(US9598440, 125)
Show SMILES COc1ccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)c(OC)c1
Show InChI InChI=1S/C27H31N5O5S/c1-27(2,35)16-12-19(23(34)22(16)33)29-24-15(25-30-18-7-5-6-8-21(18)38-25)13-28-26(32-24)31-17-10-9-14(36-3)11-20(17)37-4/h5-11,13,16,19,22-23,33-35H,12H2,1-4H3,(H2,28,29,31,32)/p+1/t16-,19+,22+,23-/m0/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302876
PNG
(US9598440, 13)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3cccc(F)c3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H22FN5O3S/c24-13-4-3-5-14(9-13)26-23-25-10-15(22-28-16-6-1-2-7-18(16)33-22)21(29-23)27-17-8-12(11-30)19(31)20(17)32/h1-7,9-10,12,17,19-20,30-32H,8,11H2,(H2,25,26,27,29)/t12-,17-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50108015
PNG
(CHEMBL3601084 | US9598440, 40)
Show SMILES Cc1cc(Nc2ncc(-c3cncs3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C20H24N6O3S/c1-10-3-13(4-11(2)23-10)24-20-22-6-14(16-7-21-9-30-16)19(26-20)25-15-5-12(8-27)17(28)18(15)29/h3-4,6-7,9,12,15,17-18,27-29H,5,8H2,1-2H3,(H2,22,23,24,25,26)/t12-,15-,17-,18+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303001
PNG
(US9598440, 142)
Show SMILES CO[C@H]1[C@@H](C[C@H](CO)[C@H]1O)Nc1nc(N)ncc1-c1nc2ccccc2s1
Show InChI InChI=1S/C18H21N5O3S/c1-26-15-12(6-9(8-24)14(15)25)21-16-10(7-20-18(19)23-16)17-22-11-4-2-3-5-13(11)27-17/h2-5,7,9,12,14-15,24-25H,6,8H2,1H3,(H3,19,20,21,23)/t9-,12-,14-,15+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303014
PNG
(US9598440, 156)
Show SMILES CO[C@H]1[C@@H](C[C@H](CO)[C@H]1O)Nc1cc(Nc2cc(C)nc(C)c2)ncc1-c1nc2ccccc2s1
Show InChI InChI=1S/C26H29N5O3S/c1-14-8-17(9-15(2)28-14)29-23-11-20(30-21-10-16(13-32)24(33)25(21)34-3)18(12-27-23)26-31-19-6-4-5-7-22(19)35-26/h4-9,11-12,16,21,24-25,32-33H,10,13H2,1-3H3,(H2,27,28,29,30)/t16-,21-,24-,25+/m1/s1
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n/an/a 83n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302961
PNG
(BDBM302966 | US9598440, 100)
Show SMILES COc1cc(Nc2nc(C)c(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
Show InChI InChI=1S/C24H26N6O4S/c1-12-19(23-29-15-5-3-4-6-17(15)35-23)22(28-16-9-13(11-31)20(32)21(16)33)30-24(26-12)27-14-7-8-25-18(10-14)34-2/h3-8,10,13,16,20-21,31-33H,9,11H2,1-2H3,(H2,25,26,27,28,30)/t13-,16-,20-,21+/m1/s1
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n/an/a 93n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302943
PNG
(US9598440, 81)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(Nc3cncnc3)ncc2-c2nc(cs2)-c2ccccc2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H23N7O3S/c31-10-14-6-17(20(33)19(14)32)28-21-16(9-26-23(30-21)27-15-7-24-12-25-8-15)22-29-18(11-34-22)13-4-2-1-3-5-13/h1-5,7-9,11-12,14,17,19-20,31-33H,6,10H2,(H2,26,27,28,30)/p+1/t14-,17-,19-,20+/m1/s1
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n/an/a 94n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303002
PNG
(US9598440, 143)
Show SMILES COC[C@H]1C[C@@H](Nc2nc(Nc3ccnc(OC)c3)ncc2-c2nc3ccccc3s2)[C@H](OC)[C@@H]1O
Show InChI InChI=1S/C25H28N6O4S/c1-33-13-14-10-18(22(35-3)21(14)32)29-23-16(24-30-17-6-4-5-7-19(17)36-24)12-27-25(31-23)28-15-8-9-26-20(11-15)34-2/h4-9,11-12,14,18,21-22,32H,10,13H2,1-3H3,(H2,26,27,28,29,31)/t14-,18-,21-,22+/m1/s1
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n/an/a 95n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302942
PNG
(US9598440, 80)
Show SMILES COc1cc(Nc2ncc(-c3nc(cs3)-c3ccccc3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)ccn1
Show InChI InChI=1S/C25H26N6O4S/c1-35-20-10-16(7-8-26-20)28-25-27-11-17(24-30-19(13-36-24)14-5-3-2-4-6-14)23(31-25)29-18-9-15(12-32)21(33)22(18)34/h2-8,10-11,13,15,18,21-22,32-34H,9,12H2,1H3,(H2,26,27,28,29,31)/p+1/t15-,18-,21-,22+/m1/s1
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n/an/a 98n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068465
PNG
(CHEMBL3403443 | US9598440, 19)
Show SMILES Nc1ncc(c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1)-c1ccc2ccccc2n1
Show InChI InChI=1S/C19H21N5O3/c20-19-21-8-12(14-6-5-10-3-1-2-4-13(10)22-14)18(24-19)23-15-7-11(9-25)16(26)17(15)27/h1-6,8,11,15-17,25-27H,7,9H2,(H3,20,21,23,24)/t11-,15-,16-,17+/m1/s1
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n/an/a 104n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50107862
PNG
(CHEMBL3601193 | US9598440, 152)
Show SMILES Nc1cc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c(cn1)-c1nc2ccccc2s1
Show InChI InChI=1S/C18H20N4O3S/c19-15-6-12(21-13-5-9(8-23)16(24)17(13)25)10(7-20-15)18-22-11-3-1-2-4-14(11)26-18/h1-4,6-7,9,13,16-17,23-25H,5,8H2,(H3,19,20,21)/t9-,13-,16-,17+/m1/s1
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n/an/a 113n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302885
PNG
(US9598440, 22)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccccc3O)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H23N5O4S/c29-11-12-9-16(20(32)19(12)31)25-21-13(22-26-15-6-2-4-8-18(15)33-22)10-24-23(28-21)27-14-5-1-3-7-17(14)30/h1-8,10,12,16,19-20,29-32H,9,11H2,(H2,24,25,27,28)/t12-,16-,19-,20+/m1/s1
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n/an/a 118n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302949
PNG
(US9598440, 87)
Show SMILES Cc1cc(Nc2nc(C)c(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)cc(C)n1
Show InChI InChI=1S/C25H28N6O3S/c1-12-8-16(9-13(2)26-12)28-25-27-14(3)20(24-30-17-6-4-5-7-19(17)35-24)23(31-25)29-18-10-15(11-32)21(33)22(18)34/h4-9,15,18,21-22,32-34H,10-11H2,1-3H3,(H2,26,27,28,29,31)/t15-,18-,21-,22+/m1/s1
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n/an/a 119n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303018
PNG
(US9598440, 160)
Show SMILES COc1cc(Nc2cc(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)c(cn2)-c2nc3ccccc3s2)ccn1
Show InChI InChI=1S/C26H29N5O4S/c1-26(2,34)16-11-19(24(33)23(16)32)30-18-12-21(29-14-8-9-27-22(10-14)35-3)28-13-15(18)25-31-17-6-4-5-7-20(17)36-25/h4-10,12-13,16,19,23-24,32-34H,11H2,1-3H3,(H2,27,28,29,30)/t16-,19+,23+,24-/m0/s1
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n/an/a 126n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303006
PNG
(US9598440, 147)
Show SMILES COc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](C)[C@@H](O)[C@H]3O)n2)ccn1
Show InChI InChI=1S/C23H24N6O3S/c1-12-9-16(20(31)19(12)30)27-21-14(22-28-15-5-3-4-6-17(15)33-22)11-25-23(29-21)26-13-7-8-24-18(10-13)32-2/h3-8,10-12,16,19-20,30-31H,9H2,1-2H3,(H2,24,25,26,27,29)/t12-,16+,19+,20-/m0/s1
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n/an/a 132n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302909
PNG
(US9598440, 47)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCCNC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H28N6O3S/c29-11-12-8-16(19(31)18(12)30)26-20-14(21-27-15-5-1-2-6-17(15)32-21)10-24-22(28-20)25-13-4-3-7-23-9-13/h1-2,5-6,10,12-13,16,18-19,23,29-31H,3-4,7-9,11H2,(H2,24,25,26,28)/t12-,13?,16-,18-,19+/m1/s1
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n/an/a 136n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302866
PNG
(US9598440, 4)
Show SMILES COc1cccc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
Show InChI InChI=1S/C24H25N5O4S/c1-33-15-6-4-5-14(10-15)26-24-25-11-16(23-28-17-7-2-3-8-19(17)34-23)22(29-24)27-18-9-13(12-30)20(31)21(18)32/h2-8,10-11,13,18,20-21,30-32H,9,12H2,1H3,(H2,25,26,27,29)/t13-,18-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302961
PNG
(BDBM302966 | US9598440, 100)
Show SMILES COc1cc(Nc2nc(C)c(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)ccn1
Show InChI InChI=1S/C24H26N6O4S/c1-12-19(23-29-15-5-3-4-6-17(15)35-23)22(28-16-9-13(11-31)20(32)21(16)33)30-24(26-12)27-14-7-8-25-18(10-14)34-2/h3-8,10,13,16,20-21,31-33H,9,11H2,1-2H3,(H2,25,26,27,28,30)/t13-,16-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302963
PNG
(US9598440, 102)
Show SMILES Cc1nc(Nc2cccc(c2)C(N)=O)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C25H26N6O4S/c1-12-19(24-30-16-7-2-3-8-18(16)36-24)23(29-17-10-14(11-32)20(33)21(17)34)31-25(27-12)28-15-6-4-5-13(9-15)22(26)35/h2-9,14,17,20-21,32-34H,10-11H2,1H3,(H2,26,35)(H2,27,28,29,31)/t14-,17-,20-,21+/m1/s1
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n/an/a 142n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302924
PNG
(US9598440, 62)
Show SMILES CC(C)n1ccc(Nc2ncc(c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)-c2ccc3ccccc3n2)cc1=O
Show InChI InChI=1S/C27H30N6O4/c1-15(2)33-10-9-18(12-23(33)35)29-27-28-13-19(21-8-7-16-5-3-4-6-20(16)30-21)26(32-27)31-22-11-17(14-34)24(36)25(22)37/h3-10,12-13,15,17,22,24-25,34,36-37H,11,14H2,1-2H3,(H2,28,29,31,32)/p+1/t17-,22-,24-,25+/m1/s1
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n/an/a 154n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302981
PNG
(US9598440, 122)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2[nH+]c(Nc3cc(F)cc(F)c3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25F2N5O3S/c1-25(2,35)16-10-18(21(34)20(16)33)30-22-15(23-31-17-5-3-4-6-19(17)36-23)11-28-24(32-22)29-14-8-12(26)7-13(27)9-14/h3-9,11,16,18,20-21,33-35H,10H2,1-2H3,(H2,28,29,30,32)/p+1/t16-,18+,20+,21-/m0/s1
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n/an/a 163n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302958
PNG
(US9598440, 97)
Show SMILES Cc1nc(Nc2ccccn2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C23H24N6O3S/c1-12-18(22-27-14-6-2-3-7-16(14)33-22)21(26-15-10-13(11-30)19(31)20(15)32)29-23(25-12)28-17-8-4-5-9-24-17/h2-9,13,15,19-20,30-32H,10-11H2,1H3,(H2,24,25,26,28,29)/t13-,15-,19-,20+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302950
PNG
(US9598440, 88)
Show SMILES Cc1nc(Nc2ccc(Cl)cc2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C24H24ClN5O3S/c1-12-19(23-29-16-4-2-3-5-18(16)34-23)22(28-17-10-13(11-31)20(32)21(17)33)30-24(26-12)27-15-8-6-14(25)7-9-15/h2-9,13,17,20-21,31-33H,10-11H2,1H3,(H2,26,27,28,30)/t13-,17-,20-,21+/m1/s1
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n/an/a 186n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302913
PNG
(US9598440, 51)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCNC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C21H26N6O3S/c28-10-11-7-15(18(30)17(11)29)25-19-13(20-26-14-3-1-2-4-16(14)31-20)9-23-21(27-19)24-12-5-6-22-8-12/h1-4,9,11-12,15,17-18,22,28-30H,5-8,10H2,(H2,23,24,25,27)/t11-,12?,15-,17-,18+/m1/s1
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n/an/a 190n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302953
PNG
(US9598440, 92)
Show SMILES Cc1nc(nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1)N1CCC(N)CC1
Show InChI InChI=1S/C23H30N6O3S/c1-12-18(22-27-15-4-2-3-5-17(15)33-22)21(26-16-10-13(11-30)19(31)20(16)32)28-23(25-12)29-8-6-14(24)7-9-29/h2-5,13-14,16,19-20,30-32H,6-11,24H2,1H3,(H,25,26,28)/t13-,16-,19-,20+/m1/s1
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n/an/a 196n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50107855
PNG
(CHEMBL3601194 | US9598440, 153)
Show SMILES OC[C@H]1C[C@@H](Nc2cc(NC3CCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H26N4O3S/c27-11-12-8-17(21(29)20(12)28)25-16-9-19(24-13-4-3-5-13)23-10-14(16)22-26-15-6-1-2-7-18(15)30-22/h1-2,6-7,9-10,12-13,17,20-21,27-29H,3-5,8,11H2,(H2,23,24,25)/t12-,17-,20-,21+/m1/s1
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n/an/a 204n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302965
PNG
(US9598440, 104)
Show SMILES Cc1nc(Nc2cccc(O)c2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C24H25N5O4S/c1-12-19(23-28-16-7-2-3-8-18(16)34-23)22(27-17-9-13(11-30)20(32)21(17)33)29-24(25-12)26-14-5-4-6-15(31)10-14/h2-8,10,13,17,20-21,30-33H,9,11H2,1H3,(H2,25,26,27,29)/t13-,17-,20-,21+/m1/s1
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n/an/a 219n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068474
PNG
(CHEMBL3403448 | US9598440, 16)
Show SMILES COCCCNc1ncc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C21H27N5O4S/c1-30-8-4-7-22-21-23-10-13(20-25-14-5-2-3-6-16(14)31-20)19(26-21)24-15-9-12(11-27)17(28)18(15)29/h2-3,5-6,10,12,15,17-18,27-29H,4,7-9,11H2,1H3,(H2,22,23,24,26)/t12-,15-,17-,18+/m1/s1
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n/an/a 228n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302875
PNG
(US9598440, 12)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3COC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C20H23N5O4S/c26-7-10-5-14(17(28)16(10)27)23-18-12(6-21-20(25-18)22-11-8-29-9-11)19-24-13-3-1-2-4-15(13)30-19/h1-4,6,10-11,14,16-17,26-28H,5,7-9H2,(H2,21,22,23,25)/t10-,14-,16-,17+/m1/s1
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n/an/a 236n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302911
PNG
(US9598440, 49)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCCOC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H27N5O4S/c28-10-12-8-16(19(30)18(12)29)25-20-14(21-26-15-5-1-2-6-17(15)32-21)9-23-22(27-20)24-13-4-3-7-31-11-13/h1-2,5-6,9,12-13,16,18-19,28-30H,3-4,7-8,10-11H2,(H2,23,24,25,27)/t12-,13?,16-,18-,19+/m1/s1
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n/an/a 238n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302926
PNG
(US9598440, 64)
Show SMILES Nc1ncc(-c2nccs2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)[nH+]1
Show InChI InChI=1S/C13H17N5O3S/c14-13-16-4-7(12-15-1-2-22-12)11(18-13)17-8-3-6(5-19)9(20)10(8)21/h1-2,4,6,8-10,19-21H,3,5H2,(H3,14,16,17,18)/p+1/t6-,8-,9-,10+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302964
PNG
(US9598440, 103)
Show SMILES Cc1nc(Nc2ccc(O)cc2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C24H25N5O4S/c1-12-19(23-28-16-4-2-3-5-18(16)34-23)22(27-17-10-13(11-30)20(32)21(17)33)29-24(25-12)26-14-6-8-15(31)9-7-14/h2-9,13,17,20-21,30-33H,10-11H2,1H3,(H2,25,26,27,29)/t13-,17-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302927
PNG
(US9598440, 65)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(Nc3ccncc3)ncc2-c2nccs2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C18H20N6O3S/c25-9-10-7-13(15(27)14(10)26)23-16-12(17-20-5-6-28-17)8-21-18(24-16)22-11-1-3-19-4-2-11/h1-6,8,10,13-15,25-27H,7,9H2,(H2,19,21,22,23,24)/p+1/t10-,13-,14-,15+/m1/s1
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n/an/a 260n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302993
PNG
(US9598440, 134)
Show SMILES Cc1csc(n1)-c1cnc(NC2CCC2)nc1N[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)C(C)(C)O
Show InChI InChI=1S/C20H29N5O3S/c1-10-9-29-18(22-10)12-8-21-19(23-11-5-4-6-11)25-17(12)24-14-7-13(20(2,3)28)15(26)16(14)27/h8-9,11,13-16,26-28H,4-7H2,1-3H3,(H2,21,23,24,25)/t13-,14+,15+,16-/m0/s1
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n/an/a 270n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068418
PNG
(CHEMBL3403437 | US9598440, 5)
Show SMILES Nc1ncc(-c2nc3ccccc3o2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C17H19N5O4/c18-17-19-6-9(16-21-10-3-1-2-4-12(10)26-16)15(22-17)20-11-5-8(7-23)13(24)14(11)25/h1-4,6,8,11,13-14,23-25H,5,7H2,(H3,18,19,20,22)/t8-,11-,13-,14+/m1/s1
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n/an/a 284n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302868
PNG
(Step 6b: ((3aR,4R,6R,6aS)-2,2-dimethyl-6-((2-(meth...)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccnc(F)c3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H21FN6O3S/c23-17-8-12(5-6-24-17)26-22-25-9-13(21-28-14-3-1-2-4-16(14)33-21)20(29-22)27-15-7-11(10-30)18(31)19(15)32/h1-6,8-9,11,15,18-19,30-32H,7,10H2,(H2,24,25,26,27,29)/t11-,15-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303005
PNG
(US9598440, 146)
Show SMILES C[C@H]1C[C@@H](Nc2nc(N)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C17H19N5O2S/c1-8-6-11(14(24)13(8)23)20-15-9(7-19-17(18)22-15)16-21-10-4-2-3-5-12(10)25-16/h2-5,7-8,11,13-14,23-24H,6H2,1H3,(H3,18,19,20,22)/t8-,11+,13+,14-/m0/s1
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n/an/a 290n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302910
PNG
(US9598440, 48)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCOC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C21H25N5O4S/c27-9-11-7-15(18(29)17(11)28)24-19-13(20-25-14-3-1-2-4-16(14)31-20)8-22-21(26-19)23-12-5-6-30-10-12/h1-4,8,11-12,15,17-18,27-29H,5-7,9-10H2,(H2,22,23,24,26)/t11-,12?,15-,17-,18+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302960
PNG
(US9598440, 99)
Show SMILES Cc1nc(Nc2cccnc2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C23H24N6O3S/c1-12-18(22-28-15-6-2-3-7-17(15)33-22)21(27-16-9-13(11-30)19(31)20(16)32)29-23(25-12)26-14-5-4-8-24-10-14/h2-8,10,13,16,19-20,30-32H,9,11H2,1H3,(H2,25,26,27,29)/t13-,16-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302908
PNG
(US9598440, 46)
Show SMILES Nc1ncc(-c2cc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C18H20N4O3S/c19-18-20-7-11(14-6-9-3-1-2-4-13(9)26-14)17(22-18)21-12-5-10(8-23)15(24)16(12)25/h1-4,6-7,10,12,15-16,23-25H,5,8H2,(H3,19,20,21,22)/t10-,12-,15-,16+/m1/s1
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n/an/a 306n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302956
PNG
(US9598440, 95)
Show SMILES Cc1nc(N)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc(Br)cs1
Show InChI InChI=1S/C14H18BrN5O3S/c1-5-9(13-19-8(15)4-24-13)12(20-14(16)17-5)18-7-2-6(3-21)10(22)11(7)23/h4,6-7,10-11,21-23H,2-3H2,1H3,(H3,16,17,18,20)/t6-,7-,10-,11+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302915
PNG
(US9598440, 53)
Show SMILES CN1CCC(CC1)Nc1ncc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C23H30N6O3S/c1-29-8-6-14(7-9-29)25-23-24-11-15(22-27-16-4-2-3-5-18(16)33-22)21(28-23)26-17-10-13(12-30)19(31)20(17)32/h2-5,11,13-14,17,19-20,30-32H,6-10,12H2,1H3,(H2,24,25,26,28)/t13-,17-,19-,20+/m1/s1
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n/an/a 328n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068476
PNG
(CHEMBL3403449 | US9598440, 15)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NCC3CC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C21H25N5O3S/c27-10-12-7-15(18(29)17(12)28)24-19-13(9-23-21(26-19)22-8-11-5-6-11)20-25-14-3-1-2-4-16(14)30-20/h1-4,9,11-12,15,17-18,27-29H,5-8,10H2,(H2,22,23,24,26)/t12-,15-,17-,18+/m1/s1
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n/an/a 333n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50107851
PNG
(CHEMBL3601197 | US9598440, 155)
Show SMILES COc1cc(Nc2cc(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)c(cn2)-c2nc3ccccc3s2)ccn1
Show InChI InChI=1S/C24H25N5O4S/c1-33-21-9-14(6-7-25-21)27-20-10-17(28-18-8-13(12-30)22(31)23(18)32)15(11-26-20)24-29-16-4-2-3-5-19(16)34-24/h2-7,9-11,13,18,22-23,30-32H,8,12H2,1H3,(H2,25,26,27,28)/t13-,18-,22-,23+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302990
PNG
(US9598440, 131)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C25H34N6O5S2/c1-25(2,34)16-12-18(21(33)20(16)32)28-22-15(23-29-17-6-4-5-7-19(17)37-23)13-26-24(30-22)27-14-8-10-31(11-9-14)38(3,35)36/h4-7,13-14,16,18,20-21,32-34H,8-12H2,1-3H3,(H2,26,27,28,30)/t16-,18+,20+,21-/m0/s1
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n/an/a 382n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302969
PNG
(US9598440, 108)
Show SMILES Cc1cc(Nc2ncc(-c3nc4ccccc4s3)c(N[C@H]3C[C@@H](CO)[C@H](O)[C@@H]3O)[nH+]2)cc(C)n1
Show InChI InChI=1S/C24H26N6O3S/c1-12-7-15(8-13(2)26-12)27-24-25-10-16(23-29-17-5-3-4-6-19(17)34-23)22(30-24)28-18-9-14(11-31)20(32)21(18)33/h3-8,10,14,18,20-21,31-33H,9,11H2,1-2H3,(H2,25,26,27,28,30)/p+1/t14-,18-,20-,21+/m0/s1
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n/an/a 384n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302980
PNG
(US9598440, 121)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2[nH+]c(Nc3cccc(c3)C(F)(F)F)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C26H26F3N5O3S/c1-25(2,37)16-11-18(21(36)20(16)35)32-22-15(23-33-17-8-3-4-9-19(17)38-23)12-30-24(34-22)31-14-7-5-6-13(10-14)26(27,28)29/h3-10,12,16,18,20-21,35-37H,11H2,1-2H3,(H2,30,31,32,34)/p+1/t16-,18+,20+,21-/m0/s1
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n/an/a 386n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068467
PNG
(CHEMBL3403445 | US9598440, 11)
Show SMILES Nc1ncc(-c2nc(cs2)-c2ccccc2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C19H21N5O3S/c20-19-21-7-12(18-23-14(9-28-18)10-4-2-1-3-5-10)17(24-19)22-13-6-11(8-25)15(26)16(13)27/h1-5,7,9,11,13,15-16,25-27H,6,8H2,(H3,20,21,22,24)/t11-,13-,15-,16+/m1/s1
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n/an/a 409n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302948
PNG
(US9598440, 86)
Show SMILES Cc1nc(Nc2ccnc(F)c2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C23H23FN6O3S/c1-11-18(22-29-14-4-2-3-5-16(14)34-22)21(28-15-8-12(10-31)19(32)20(15)33)30-23(26-11)27-13-6-7-25-17(24)9-13/h2-7,9,12,15,19-20,31-33H,8,10H2,1H3,(H2,25,26,27,28,30)/t12-,15-,19-,20+/m1/s1
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n/an/a 430n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302898
PNG
(US9598440, 36)
Show SMILES COc1cccc(c1)[C@@H](C)Nc1ncc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C26H29N5O4S/c1-14(15-6-5-7-17(10-15)35-2)28-26-27-12-18(25-30-19-8-3-4-9-21(19)36-25)24(31-26)29-20-11-16(13-32)22(33)23(20)34/h3-10,12,14,16,20,22-23,32-34H,11,13H2,1-2H3,(H2,27,28,29,31)/t14-,16-,20-,22-,23+/m1/s1
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n/an/a 470n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302918
PNG
(US9598440, 56)
Show SMILES OC[C@H]1CC(Nc2[nH+]c(NC3CCC3)ncc2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C23H27N5O3/c29-12-14-10-19(21(31)20(14)30)27-22-16(11-24-23(28-22)25-15-5-3-6-15)18-9-8-13-4-1-2-7-17(13)26-18/h1-2,4,7-9,11,14-15,19-21,29-31H,3,5-6,10,12H2,(H2,24,25,27,28)/p+1/t14-,19?,20-,21+/m1/s1
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n/an/a 483n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302895
PNG
(US9598440, 33)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H27N5O3S/c28-11-12-9-16(19(30)18(12)29)25-20-14(21-26-15-7-3-4-8-17(15)31-21)10-23-22(27-20)24-13-5-1-2-6-13/h3-4,7-8,10,12-13,16,18-19,28-30H,1-2,5-6,9,11H2,(H2,23,24,25,27)/t12-,16-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302870
PNG
(US9598440, 8)
Show SMILES Cc1cnccc1Nc1ncc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C23H24N6O3S/c1-12-9-24-7-6-15(12)28-23-25-10-14(22-27-16-4-2-3-5-18(16)33-22)21(29-23)26-17-8-13(11-30)19(31)20(17)32/h2-7,9-10,13,17,19-20,30-32H,8,11H2,1H3,(H2,24,25,26,28,29)/t13-,17-,19-,20+/m1/s1
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n/an/a 516n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302967
PNG
(US9598440, 106)
Show SMILES Cc1nc(Nc2cccc(Cl)c2)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2s1
Show InChI InChI=1S/C24H24ClN5O3S/c1-12-19(23-29-16-7-2-3-8-18(16)34-23)22(28-17-9-13(11-31)20(32)21(17)33)30-24(26-12)27-15-6-4-5-14(25)10-15/h2-8,10,13,17,20-21,31-33H,9,11H2,1H3,(H2,26,27,28,30)/t13-,17-,20-,21+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302904
PNG
(US9598440, 42)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(Nc3ccc(OC(F)(F)F)cc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C24H22F3N5O4S/c25-24(26,27)36-14-7-5-13(6-8-14)29-23-28-10-15(22-31-16-3-1-2-4-18(16)37-22)21(32-23)30-17-9-12(11-33)19(34)20(17)35/h1-8,10,12,17,19-20,33-35H,9,11H2,(H2,28,29,30,32)/t12-,17-,19-,20+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302938
PNG
(US9598440, 76)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(NC3CCC3)ncc2-c2nc3cnccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C20H24N6O3S/c27-9-10-6-13(17(29)16(10)28)24-18-12(7-22-20(26-18)23-11-2-1-3-11)19-25-14-8-21-5-4-15(14)30-19/h4-5,7-8,10-11,13,16-17,27-29H,1-3,6,9H2,(H2,22,23,24,26)/p+1/t10-,13-,16-,17+/m1/s1
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n/an/a 560n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50068417
PNG
(CHEMBL3403436 | US9598440, 38)
Show SMILES Nc1ncc(c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1)-c1ccccn1
Show InChI InChI=1S/C15H19N5O3/c16-15-18-6-9(10-3-1-2-4-17-10)14(20-15)19-11-5-8(7-21)12(22)13(11)23/h1-4,6,8,11-13,21-23H,5,7H2,(H3,16,18,19,20)/t8-,11-,12-,13+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302914
PNG
(US9598440, 52)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCNCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H28N6O3S/c29-11-12-9-16(19(31)18(12)30)26-20-14(21-27-15-3-1-2-4-17(15)32-21)10-24-22(28-20)25-13-5-7-23-8-6-13/h1-4,10,12-13,16,18-19,23,29-31H,5-9,11H2,(H2,24,25,26,28)/t12-,16-,18-,19+/m1/s1
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302982
PNG
(US9598440, 123)
Show SMILES COc1cc(Nc2ncc(c(N[C@@H]3C[C@@H]([C@@H](O)[C@H]3O)C(C)(C)O)[nH+]2)-c2ccc3cccc(C)c3n2)ccn1
Show InChI InChI=1S/C28H32N6O4/c1-15-6-5-7-16-8-9-20(32-23(15)16)18-14-30-27(31-17-10-11-29-22(12-17)38-4)34-26(18)33-21-13-19(28(2,3)37)24(35)25(21)36/h5-12,14,19,21,24-25,35-37H,13H2,1-4H3,(H2,29,30,31,33,34)/p+1/t19-,21+,24+,25-/m0/s1
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n/an/a 712n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302916
PNG
(US9598440, 54)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CNC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C20H24N6O3S/c27-9-10-5-14(17(29)16(10)28)24-18-12(8-22-20(26-18)23-11-6-21-7-11)19-25-13-3-1-2-4-15(13)30-19/h1-4,8,10-11,14,16-17,21,27-29H,5-7,9H2,(H2,22,23,24,26)/t10-,14-,16-,17+/m1/s1
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n/an/a 736n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302955
PNG
(US9598440, 94)
Show SMILES COc1cccc(Nc2nc(C)c(-c3nc4ccccc4s3)c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c1
Show InChI InChI=1S/C25H27N5O4S/c1-13-20(24-29-17-8-3-4-9-19(17)35-24)23(28-18-10-14(12-31)21(32)22(18)33)30-25(26-13)27-15-6-5-7-16(11-15)34-2/h3-9,11,14,18,21-22,31-33H,10,12H2,1-2H3,(H2,26,27,28,30)/t14-,18-,21-,22+/m1/s1
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n/an/a 870n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303019
PNG
(US9598440, 161)
Show SMILES CC(C)(O)[C@H]1C[C@@H](Nc2cc(NC3CCC3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C24H30N4O3S/c1-24(2,31)15-10-18(22(30)21(15)29)27-17-11-20(26-13-6-5-7-13)25-12-14(17)23-28-16-8-3-4-9-19(16)32-23/h3-4,8-9,11-13,15,18,21-22,29-31H,5-7,10H2,1-2H3,(H2,25,26,27)/t15-,18+,21+,22-/m0/s1
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n/an/a 890n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302947
PNG
(US9598440, 85)
Show SMILES Cc1cc(Nc2ncc(c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)-n2cccn2)cc(C)n1
Show InChI InChI=1S/C20H25N7O3/c1-11-6-14(7-12(2)23-11)24-20-21-9-16(27-5-3-4-22-27)19(26-20)25-15-8-13(10-28)17(29)18(15)30/h3-7,9,13,15,17-18,28-30H,8,10H2,1-2H3,(H2,21,23,24,25,26)/p+1/t13-,15-,17-,18+/m1/s1
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n/an/a 932n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302894
PNG
(US9598440, 32)
Show SMILES CN1CCCC(C1)Nc1ncc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C23H30N6O3S/c1-29-8-4-5-14(11-29)25-23-24-10-15(22-27-16-6-2-3-7-18(16)33-22)21(28-23)26-17-9-13(12-30)19(31)20(17)32/h2-3,6-7,10,13-14,17,19-20,30-32H,4-5,8-9,11-12H2,1H3,(H2,24,25,26,28)/t13-,14?,17-,19-,20+/m1/s1
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n/an/a 934n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302959
PNG
(US9598440, 98)
Show SMILES CC1CCN(CC1)c1nc(C)c(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C24H31N5O3S/c1-13-7-9-29(10-8-13)24-25-14(2)19(23-27-16-5-3-4-6-18(16)33-23)22(28-24)26-17-11-15(12-30)20(31)21(17)32/h3-6,13,15,17,20-21,30-32H,7-12H2,1-2H3,(H,25,26,28)/t15-,17-,20-,21+/m1/s1
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n/an/a 948n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302962
PNG
(US9598440, 101)
Show SMILES Cc1nc(N)nc(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)c1-c1nc2ccccc2o1
Show InChI InChI=1S/C18H21N5O4/c1-8-13(17-22-10-4-2-3-5-12(10)27-17)16(23-18(19)20-8)21-11-6-9(7-24)14(25)15(11)26/h2-5,9,11,14-15,24-26H,6-7H2,1H3,(H3,19,20,21,23)/t9-,11-,14-,15+/m1/s1
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n/an/a 992n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50107854
PNG
(CHEMBL3601195 | US9598440, 151)
Show SMILES OC[C@H]1C[C@@H](Nc2cc(Nc3ccc(F)cc3)ncc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C24H23FN4O3S/c25-14-5-7-15(8-6-14)27-21-10-18(28-19-9-13(12-30)22(31)23(19)32)16(11-26-21)24-29-17-3-1-2-4-20(17)33-24/h1-8,10-11,13,19,22-23,30-32H,9,12H2,(H2,26,27,28)/t13-,19-,22-,23+/m1/s1
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n/an/a 1.14E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM303004
PNG
(US9598440, 145)
Show SMILES Nc1ncc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@@H]2F)n1
Show InChI InChI=1S/C17H18FN5O2S/c18-13-11(5-8(7-24)14(13)25)21-15-9(6-20-17(19)23-15)16-22-10-3-1-2-4-12(10)26-16/h1-4,6,8,11,13-14,24-25H,5,7H2,(H3,19,20,21,23)/t8-,11-,13-,14-/m1/s1
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n/an/a 1.33E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302922
PNG
(US9598440, 60)
Show SMILES OC[C@H]1CC(Nc2[nH+]c(NC3CC3)ncc2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H25N5O3/c28-11-13-9-18(20(30)19(13)29)26-21-15(10-23-22(27-21)24-14-6-7-14)17-8-5-12-3-1-2-4-16(12)25-17/h1-5,8,10,13-14,18-20,28-30H,6-7,9,11H2,(H2,23,24,26,27)/p+1/t13-,18?,19-,20+/m1/s1
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n/an/a 1.47E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302944
PNG
(US9598440, 82)
Show SMILES OC[C@H]1C[C@@H](Nc2[nH+]c(Nc3cccnc3)ncc2-c2nc(cs2)-c2ccccc2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C24H24N6O3S/c31-12-15-9-18(21(33)20(15)32)28-22-17(11-26-24(30-22)27-16-7-4-8-25-10-16)23-29-19(13-34-23)14-5-2-1-3-6-14/h1-8,10-11,13,15,18,20-21,31-33H,9,12H2,(H2,26,27,28,30)/p+1/t15-,18-,20-,21+/m1/s1
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n/an/a 3.21E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302946
PNG
(US9598440, 84)
Show SMILES COc1cc(Nc2ncc(c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)[nH+]2)-n2cccn2)ccn1
Show InChI InChI=1S/C19H23N7O4/c1-30-15-8-12(3-5-20-15)23-19-21-9-14(26-6-2-4-22-26)18(25-19)24-13-7-11(10-27)16(28)17(13)29/h2-6,8-9,11,13,16-17,27-29H,7,10H2,1H3,(H2,20,21,23,24,25)/p+1/t11-,13-,16-,17+/m1/s1
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n/an/a 6.01E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50107850
PNG
(CHEMBL3601198 | US9598440, 158)
Show SMILES Nc1ccc(-c2nc3ccccc3s2)c(N[C@@H]2C[C@H](CO)[C@@H](O)[C@H]2O)n1
Show InChI InChI=1S/C18H20N4O3S/c19-14-6-5-10(18-21-11-3-1-2-4-13(11)26-18)17(22-14)20-12-7-9(8-23)15(24)16(12)25/h1-6,9,12,15-16,23-25H,7-8H2,(H3,19,20,22)/t9-,12-,15-,16+/m1/s1
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n/an/a 9.51E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM302919
PNG
(US9598440, 57)
Show SMILES OC[C@H]1CC(Nc2[nH+]c(NC3COC3)ncc2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H25N5O4/c28-9-13-7-18(20(30)19(13)29)26-21-15(8-23-22(27-21)24-14-10-31-11-14)17-6-5-12-3-1-2-4-16(12)25-17/h1-6,8,13-14,18-20,28-30H,7,9-11H2,(H2,23,24,26,27)/p+1/t13-,18?,19-,20+/m1/s1
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n/an/a 1.06E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50107849
PNG
(CHEMBL3601199 | US9598440, 157)
Show SMILES OC[C@H]1C[C@@H](Nc2nc(NC3CCC3)ccc2-c2nc3ccccc3s2)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C22H26N4O3S/c27-11-12-10-16(20(29)19(12)28)24-21-14(8-9-18(26-21)23-13-4-3-5-13)22-25-15-6-1-2-7-17(15)30-22/h1-2,6-9,12-13,16,19-20,27-29H,3-5,10-11H2,(H2,23,24,26)/t12-,16-,19-,20+/m1/s1
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n/an/a 1.19E+4n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
Procedure: A 20 μl reaction mixture contains 10 mM TriHCl, pH 7.2, 0.5 nM GST tagged IRAK4 (SignalChem), 100 nM fluorescent peptide substrate (R...


US Patent US9598440 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%