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Patent code US9603836

Compile Data Set for Download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM310195
PNG
((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Show SMILES Fc1ccc2[nH]cc([C@H]3CC(=O)NC3=O)c2c1
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US Patent
n/an/a 120n/an/an/an/an/an/a



ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM309529
PNG
(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM309529
PNG
(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312073
PNG
(3-(6-bromo-5-fluoro- 1H-indol-3-yl)- pyrrolidine-2...)
Show SMILES Fc1cc2c(c[nH]c2cc1Br)C1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312076
PNG
(3-(5-bromo-1H-indol-3- yl)pyrrolidine-2,5-dione | ...)
Show SMILES Brc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312084
PNG
(3-(6-bromo-1H-indol-3- yl)pyrrolidine-2,5-dione | ...)
Show SMILES Brc1ccc2c(c[nH]c2c1)C1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312072
PNG
(3-(6-chloro-5-fluoro-1H- indol-3-yl)pyrrolidine- 2...)
Show SMILES Fc1cc2c(c[nH]c2cc1Cl)C1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312074
PNG
((R)-3-(6-bromo-5- fluoro-1H-indol-3-yl)- pyrrolidi...)
Show SMILES Fc1cc2c(c[nH]c2cc1Br)[C@H]1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312088
PNG
(3-(6-fluoronaphthanlen- 1-yl)pyrrolidine-2,5- dion...)
Show SMILES Fc1ccc2c(cccc2c1)C1CC(=O)NC1=O
Show InChI InChI=1S/C14H10FNO2/c15-9-4-5-10-8(6-9)2-1-3-11(10)12-7-13(17)16-14(12)18/h1-6,12H,7H2,(H,16,17,18)
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312086
PNG
(3-(2,5-dioxopyrrolidin- 3-yl)-1H-indole-6- carboni...)
Show SMILES O=C1CC(C(=O)N1)c1c[nH]c2cc(ccc12)[N+]#[C-]
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312080
PNG
(3-(5,6-difluoro-1H- indol-3-yl)pyrrolidine- 2,5-di...)
Show SMILES Fc1cc2[nH]cc(C3CC(=O)NC3=O)c2cc1F
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312064
PNG
((-)-(R)-3-(1H-indol-3- yl)pyrrolidine-2,5-dione | ...)
Show SMILES O=C1C[C@@H](C(=O)N1)c1c[nH]c2ccccc12
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312083
PNG
(3-(6-chloro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Show SMILES Clc1ccc2c(c[nH]c2c1)C1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312069
PNG
(3-(5-chloro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Show SMILES Clc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312070
PNG
((-)-(R)-3-(5-chloro-1H- indol-3-yl)pyrrolidine- 2,...)
Show SMILES Clc1ccc2[nH]cc([C@H]3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM73346
PNG
(3-(1H-indol-3-yl)-2,5-pyrrolidinedione | 3-(1H-ind...)
Show SMILES O=C1CC(C(=O)N1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-11-5-8(12(16)14-11)9-6-13-10-4-2-1-3-7(9)10/h1-4,6,8,13H,5H2,(H,14,15,16)
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US Patent
n/an/a 3.00E+3n/an/an/an/an/an/a



ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312082
PNG
(3-(6-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Show SMILES Fc1ccc2c(c[nH]c2c1)C1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312089
PNG
(3-(7-fluoronaphthanlen- 1-yl)pyrrolidine-2,5- dion...)
Show SMILES Fc1ccc2cccc(C3CC(=O)NC3=O)c2c1
Show InChI InChI=1S/C14H10FNO2/c15-9-5-4-8-2-1-3-10(11(8)6-9)12-7-13(17)16-14(12)18/h1-6,12H,7H2,(H,16,17,18)
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312075
PNG
(US9603836, Compound 10a)
Show SMILES Fc1cc2c(c[nH]c2cc1Br)[C@@H]1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312079
PNG
(3-(2,5-dioxopyrrolidin- 3-yl)-1H-indole-5- carboni...)
Show SMILES O=C1CC(C(=O)N1)c1c[nH]c2ccc(cc12)[N+]#[C-]
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US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312087
PNG
(3-(naphthalen-1-yl)- pyrrolidine-2,5-dione | US960...)
Show SMILES O=C1CC(C(=O)N1)c1cccc2ccccc12
Show InChI InChI=1S/C14H11NO2/c16-13-8-12(14(17)15-13)11-7-3-5-9-4-1-2-6-10(9)11/h1-7,12H,8H2,(H,15,16,17)
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312081
PNG
(3-(5-fluoro-6-methyl- 1H-indol-3-yl)- pyrrolidine-...)
Show SMILES Cc1cc2[nH]cc(C3CC(=O)NC3=O)c2cc1F
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US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312071
PNG
(US9603836, Compound 6a)
Show SMILES Clc1ccc2[nH]cc([C@@H]3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM310197
PNG
(US9603836, Compound 2a)
Show SMILES Fc1ccc2[nH]cc([C@@H]3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312065
PNG
(US9603836, Compound 4a)
Show SMILES O=C1C[C@H](C(=O)N1)c1c[nH]c2ccccc12
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US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312078
PNG
(3-(5-methoxy-1H-indol- 3-yl)pyrrolidine-2,5- dione...)
Show SMILES OCc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312077
PNG
(3-(5-methyl-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Show SMILES Cc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
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US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1


(Homo sapiens (human))
BDBM312085
PNG
(3-(6-methyl-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Show SMILES Cc1ccc2c(c[nH]c2c1)C1CC(=O)NC1=O
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ITEOS THERAPEUTICS

US Patent


Assay Description
To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...


US Patent US9603836 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%