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Patent code US9604982

Compile Data Set for Download or QSAR

Found 678 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173376
PNG
(US9096596, 89 | US9604982, Example 89)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17ClFN5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m0/s1
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1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173376
PNG
(US9096596, 89 | US9604982, Example 89)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17ClFN5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173371
PNG
(US9096596, 84 | US9604982, Example 84)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173371
PNG
(US9096596, 84 | US9604982, Example 84)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173337
PNG
(US9096596, 58 | US9604982, Example 58)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1Cl)C(F)(F)F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C20H17ClF3N5O/c1-10-8-13-16(26-11(2)27-18(13)15-6-7-25-28-15)9-29(10)19(30)12-4-3-5-14(17(12)21)20(22,23)24/h3-7,10H,8-9H2,1-2H3,(H,25,28)/t10-/m1/s1
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2.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173337
PNG
(US9096596, 58 | US9604982, Example 58)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1Cl)C(F)(F)F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C20H17ClF3N5O/c1-10-8-13-16(26-11(2)27-18(13)15-6-7-25-28-15)9-29(10)19(30)12-4-3-5-14(17(12)21)20(22,23)24/h3-7,10H,8-9H2,1-2H3,(H,25,28)/t10-/m1/s1
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2.80n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173415
PNG
(US9096596, 128 | US9604982, Example 128)
Show SMILES COCCn1ccc(n1)-c1nc(C)nc2CN([C@H](C)Cc12)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H23ClF3N5O2/c1-13-11-16-19(28-14(2)29-21(16)18-7-8-31(30-18)9-10-34-3)12-32(13)22(33)15-5-4-6-17(20(15)24)23(25,26)27/h4-8,13H,9-12H2,1-3H3/t13-/m1/s1
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3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173415
PNG
(US9096596, 128 | US9604982, Example 128)
Show SMILES COCCn1ccc(n1)-c1nc(C)nc2CN([C@H](C)Cc12)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C23H23ClF3N5O2/c1-13-11-16-19(28-14(2)29-21(16)18-7-8-31(30-18)9-10-34-3)12-32(13)22(33)15-5-4-6-17(20(15)24)23(25,26)27/h4-8,13H,9-12H2,1-3H3/t13-/m1/s1
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3n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US9096596, 20 | US9604982, Example 20)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
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3.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173411
PNG
(US9096596, 124 | US9604982, Example 124)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1Cl)C(F)(F)F)nc(C)nc2-c1ccn(CCF)n1
Show InChI InChI=1S/C22H20ClF4N5O/c1-12-10-15-18(28-13(2)29-20(15)17-6-8-31(30-17)9-7-24)11-32(12)21(33)14-4-3-5-16(19(14)23)22(25,26)27/h3-6,8,12H,7,9-11H2,1-2H3/t12-/m1/s1
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3.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173268
PNG
(US9096596, 20 | US9604982, Example 20)
Show SMILES Fc1c(Cl)ccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5O/c18-11-2-1-10(14(19)15(11)20)17(26)25-6-4-9-13(7-25)21-8-22-16(9)12-3-5-23-24-12/h1-3,5,8H,4,6-7H2,(H,23,24)
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3.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173411
PNG
(US9096596, 124 | US9604982, Example 124)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1Cl)C(F)(F)F)nc(C)nc2-c1ccn(CCF)n1
Show InChI InChI=1S/C22H20ClF4N5O/c1-12-10-15-18(28-13(2)29-20(15)17-6-8-31(30-17)9-7-24)11-32(12)21(33)14-4-3-5-16(19(14)23)22(25,26)27/h3-6,8,12H,7,9-11H2,1-2H3/t12-/m1/s1
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3.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173266
PNG
(US9096596, 18 | US9604982, Example 18)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C18H13ClF3N5O/c19-15-11(2-1-3-12(15)18(20,21)22)17(28)27-7-5-10-14(8-27)23-9-24-16(10)13-4-6-25-26-13/h1-4,6,9H,5,7-8H2,(H,25,26)
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5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173266
PNG
(US9096596, 18 | US9604982, Example 18)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-c2ccn[nH]2)c1Cl
Show InChI InChI=1S/C18H13ClF3N5O/c19-15-11(2-1-3-12(15)18(20,21)22)17(28)27-7-5-10-14(8-27)23-9-24-16(10)13-4-6-25-26-13/h1-4,6,9H,5,7-8H2,(H,25,26)
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5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173362
PNG
(US9096596, 75 | US9604982, Example 75)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1F)C(F)(F)F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C20H17F4N5O/c1-10-8-13-16(26-11(2)27-18(13)15-6-7-25-28-15)9-29(10)19(30)12-4-3-5-14(17(12)21)20(22,23)24/h3-7,10H,8-9H2,1-2H3,(H,25,28)/t10-/m1/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173362
PNG
(US9096596, 75 | US9604982, Example 75)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1F)C(F)(F)F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C20H17F4N5O/c1-10-8-13-16(26-11(2)27-18(13)15-6-7-25-28-15)9-29(10)19(30)12-4-3-5-14(17(12)21)20(22,23)24/h3-7,10H,8-9H2,1-2H3,(H,25,28)/t10-/m1/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM312630
PNG
((R*)-(2-chloro-3-fluorophenyl)(2,6-dimethyl-4-(1H-...)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(F)c1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17ClFN5O/c1-10-8-13-16(23-11(2)24-18(13)15-6-7-22-25-15)9-26(10)19(27)12-4-3-5-14(21)17(12)20/h3-7,10H,8-9H2,1-2H3,(H,22,25)/t10-/m1/s1
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7.40n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173376
PNG
(US9096596, 89 | US9604982, Example 89)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17ClFN5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m0/s1
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7.70n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173400
PNG
(US9096596, 113 | US9604982, Example 113)
Show SMILES C[C@H]1N(CCc2c1ncnc2-c1ccn[nH]1)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5O/c1-10-16-12(17(25-9-24-16)14-5-7-26-27-14)6-8-28(10)18(29)11-3-2-4-13(15(11)20)19(21,22)23/h2-5,7,9-10H,6,8H2,1H3,(H,26,27)/t10-/m1/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173365
PNG
(US9096596, 78 | US9604982, Example 78)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1C)C(F)(F)F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C21H20F3N5O/c1-11-9-15-18(26-13(3)27-19(15)17-7-8-25-28-17)10-29(11)20(30)14-5-4-6-16(12(14)2)21(22,23)24/h4-8,11H,9-10H2,1-3H3,(H,25,28)/t11-/m1/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173400
PNG
(US9096596, 113 | US9604982, Example 113)
Show SMILES C[C@H]1N(CCc2c1ncnc2-c1ccn[nH]1)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5O/c1-10-16-12(17(25-9-24-16)14-5-7-26-27-14)6-8-28(10)18(29)11-3-2-4-13(15(11)20)19(21,22)23/h2-5,7,9-10H,6,8H2,1H3,(H,26,27)/t10-/m1/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173272
PNG
(US9096596, 108 | US9096596, 24 | US9604982, Exampl...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C17H12ClF3N6O/c18-14-11(2-1-3-12(14)17(19,20)21)16(28)26-7-4-10-13(8-26)22-9-23-15(10)27-24-5-6-25-27/h1-3,5-6,9H,4,7-8H2
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173365
PNG
(US9096596, 78 | US9604982, Example 78)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1cccc(c1C)C(F)(F)F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C21H20F3N5O/c1-11-9-15-18(26-13(3)27-19(15)17-7-8-25-28-17)10-29(11)20(30)14-5-4-6-16(12(14)2)21(22,23)24/h4-8,11H,9-10H2,1-3H3,(H,25,28)/t11-/m1/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173368
PNG
(US9096596, 81 | US9604982, Example 81)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(F)c(Cl)c1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H16Cl2FN5O/c1-9-7-12-15(24-10(2)25-18(12)14-5-6-23-26-14)8-27(9)19(28)11-3-4-13(22)17(21)16(11)20/h3-6,9H,7-8H2,1-2H3,(H,23,26)/t9-/m1/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173368
PNG
(US9096596, 81 | US9604982, Example 81)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(F)c(Cl)c1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H16Cl2FN5O/c1-9-7-12-15(24-10(2)25-18(12)14-5-6-23-26-14)8-27(9)19(28)11-3-4-13(22)17(21)16(11)20/h3-6,9H,7-8H2,1-2H3,(H,23,26)/t9-/m1/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173272
PNG
(US9096596, 108 | US9096596, 24 | US9604982, Exampl...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C17H12ClF3N6O/c18-14-11(2-1-3-12(14)17(19,20)21)16(28)26-7-4-10-13(8-26)22-9-23-15(10)27-24-5-6-25-27/h1-3,5-6,9H,4,7-8H2
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173272
PNG
(US9096596, 108 | US9096596, 24 | US9604982, Exampl...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C17H12ClF3N6O/c18-14-11(2-1-3-12(14)17(19,20)21)16(28)26-7-4-10-13(8-26)22-9-23-15(10)27-24-5-6-25-27/h1-3,5-6,9H,4,7-8H2
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173272
PNG
(US9096596, 108 | US9096596, 24 | US9604982, Exampl...)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C17H12ClF3N6O/c18-14-11(2-1-3-12(14)17(19,20)21)16(28)26-7-4-10-13(8-26)22-9-23-15(10)27-24-5-6-25-27/h1-3,5-6,9H,4,7-8H2
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173271
PNG
(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Show SMILES Clc1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C16H12Cl2N6O/c17-12-3-1-2-11(14(12)18)16(25)23-7-4-10-13(8-23)19-9-20-15(10)24-21-5-6-22-24/h1-3,5-6,9H,4,7-8H2
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9.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173271
PNG
(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Show SMILES Clc1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C16H12Cl2N6O/c17-12-3-1-2-11(14(12)18)16(25)23-7-4-10-13(8-23)19-9-20-15(10)24-21-5-6-22-24/h1-3,5-6,9H,4,7-8H2
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9.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173271
PNG
(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Show SMILES Clc1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C16H12Cl2N6O/c17-12-3-1-2-11(14(12)18)16(25)23-7-4-10-13(8-23)19-9-20-15(10)24-21-5-6-22-24/h1-3,5-6,9H,4,7-8H2
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9.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173271
PNG
(US9096596, 107 | US9096596, 23 | US9604982, Exampl...)
Show SMILES Clc1cccc(C(=O)N2CCc3c(C2)ncnc3-n2nccn2)c1Cl
Show InChI InChI=1S/C16H12Cl2N6O/c17-12-3-1-2-11(14(12)18)16(25)23-7-4-10-13(8-23)19-9-20-15(10)24-21-5-6-22-24/h1-3,5-6,9H,4,7-8H2
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9.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173310
PNG
(US9096596, 43 | US9604982, Example 43)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-c2cscn2)c1Cl
Show InChI InChI=1S/C18H12ClF3N4OS/c19-15-11(2-1-3-12(15)18(20,21)22)17(27)26-5-4-10-13(6-26)23-8-24-16(10)14-7-28-9-25-14/h1-3,7-9H,4-6H2
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173310
PNG
(US9096596, 43 | US9604982, Example 43)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-c2cscn2)c1Cl
Show InChI InChI=1S/C18H12ClF3N4OS/c19-15-11(2-1-3-12(15)18(20,21)22)17(27)26-5-4-10-13(6-26)23-8-24-16(10)14-7-28-9-25-14/h1-3,7-9H,4-6H2
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173371
PNG
(US9096596, 84 | US9604982, Example 84)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m1/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173371
PNG
(US9096596, 84 | US9604982, Example 84)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m1/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173376
PNG
(US9096596, 89 | US9604982, Example 89)
Show SMILES C[C@H]1Cc2c(CN1C(=O)c1ccc(Cl)cc1F)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17ClFN5O/c1-10-7-14-17(23-11(2)24-18(14)16-5-6-22-25-16)9-26(10)19(27)13-4-3-12(20)8-15(13)21/h3-6,8,10H,7,9H2,1-2H3,(H,22,25)/t10-/m0/s1
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11.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173295
PNG
(US9096596, 33 | US9604982, Example 33)
Show SMILES Cc1nc2CN(CCc2c(n1)-c1ccn[nH]1)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5O/c1-10-25-15-9-28(8-6-11(15)17(26-10)14-5-7-24-27-14)18(29)12-3-2-4-13(16(12)20)19(21,22)23/h2-5,7H,6,8-9H2,1H3,(H,24,27)
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173295
PNG
(US9096596, 33 | US9604982, Example 33)
Show SMILES Cc1nc2CN(CCc2c(n1)-c1ccn[nH]1)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5O/c1-10-25-15-9-28(8-6-11(15)17(26-10)14-5-7-24-27-14)18(29)12-3-2-4-13(16(12)20)19(21,22)23/h2-5,7H,6,8-9H2,1H3,(H,24,27)
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12n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173396
PNG
(US9096596, 109 | US9604982, Example 109)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-n2cnnc2)c1Cl
Show InChI InChI=1S/C17H12ClF3N6O/c18-14-11(2-1-3-12(14)17(19,20)21)16(28)26-5-4-10-13(6-26)22-7-23-15(10)27-8-24-25-9-27/h1-3,7-9H,4-6H2
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173405
PNG
(US9096596, 118 | US9604982, Example 118)
Show SMILES CC1N(CCc2c1ncnc2-c1ccn[nH]1)C(=O)c1ccc(F)c(Cl)c1Cl
Show InChI InChI=1S/C18H14Cl2FN5O/c1-9-16-11(17(23-8-22-16)13-4-6-24-25-13)5-7-26(9)18(27)10-2-3-12(21)15(20)14(10)19/h2-4,6,8-9H,5,7H2,1H3,(H,24,25)
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173298
PNG
(US9096596, 35 | US9604982, Example 35)
Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173349
PNG
(US9096596, 67 | US9604982, Example 67)
Show SMILES CC1Cc2c(CN1C(=O)c1cccc(Cl)c1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10-8-13-16(23-11(2)24-18(13)15-6-7-22-25-15)9-26(10)19(27)12-4-3-5-14(20)17(12)21/h3-7,10H,8-9H2,1-2H3,(H,22,25)
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173406
PNG
(US9096596, 119 | US9604982, Example 119)
Show SMILES C[C@H]1N(CCc2c1ncnc2-c1ccn[nH]1)C(=O)c1ccc(F)c(Cl)c1Cl
Show InChI InChI=1S/C18H14Cl2FN5O/c1-9-16-11(17(23-8-22-16)13-4-6-24-25-13)5-7-26(9)18(27)10-2-3-12(21)15(20)14(10)19/h2-4,6,8-9H,5,7H2,1H3,(H,24,25)/t9-/m1/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM173298
PNG
(US9096596, 35 | US9604982, Example 35)
Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173396
PNG
(US9096596, 109 | US9604982, Example 109)
Show SMILES FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-n2cnnc2)c1Cl
Show InChI InChI=1S/C17H12ClF3N6O/c18-14-11(2-1-3-12(14)17(19,20)21)16(28)26-5-4-10-13(6-26)22-7-23-15(10)27-8-24-25-9-27/h1-3,7-9H,4-6H2
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173349
PNG
(US9096596, 67 | US9604982, Example 67)
Show SMILES CC1Cc2c(CN1C(=O)c1cccc(Cl)c1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H17Cl2N5O/c1-10-8-13-16(23-11(2)24-18(13)15-6-7-22-25-15)9-26(10)19(27)12-4-3-5-14(20)17(12)21/h3-7,10H,8-9H2,1-2H3,(H,22,25)
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173406
PNG
(US9096596, 119 | US9604982, Example 119)
Show SMILES C[C@H]1N(CCc2c1ncnc2-c1ccn[nH]1)C(=O)c1ccc(F)c(Cl)c1Cl
Show InChI InChI=1S/C18H14Cl2FN5O/c1-9-16-11(17(23-8-22-16)13-4-6-24-25-13)5-7-26(9)18(27)10-2-3-12(21)15(20)14(10)19/h2-4,6,8-9H,5,7H2,1H3,(H,24,25)/t9-/m1/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173405
PNG
(US9096596, 118 | US9604982, Example 118)
Show SMILES CC1N(CCc2c1ncnc2-c1ccn[nH]1)C(=O)c1ccc(F)c(Cl)c1Cl
Show InChI InChI=1S/C18H14Cl2FN5O/c1-9-16-11(17(23-8-22-16)13-4-6-24-25-13)5-7-26(9)18(27)10-2-3-12(21)15(20)14(10)19/h2-4,6,8-9H,5,7H2,1H3,(H,24,25)
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM173353
PNG
(US9096596, 71 | US9604982, Example 71)
Show SMILES C[C@@H]1Cc2c(CN1C(=O)c1ccc(Cl)c(F)c1Cl)nc(C)nc2-c1ccn[nH]1
Show InChI InChI=1S/C19H16Cl2FN5O/c1-9-7-12-15(24-10(2)25-18(12)14-5-6-23-26-14)8-27(9)19(28)11-3-4-13(20)17(22)16(11)21/h3-6,9H,7-8H2,1-2H3,(H,23,26)/t9-/m1/s1
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12.6n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9604982 (2017)

More data for this
Ligand-Target Pair
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