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Patent code US9604989

Compile Data Set for Download or QSAR
Found 159 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312567
PNG
(1-[4-(6-Methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b...)
Show SMILES COc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3
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n/an/a 2.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312579
PNG
(US9604989, Example 65)
Show SMILES CNC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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n/an/a 2.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312522
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-8-methoxy-3-phenyl...)
Show SMILES COc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-16(30)20-15-21(31-2)24-27-22(23(29(24)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3
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n/an/a 2.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312579
PNG
(US9604989, Example 65)
Show SMILES CNC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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n/an/a 3.10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312575
PNG
(US9604989, Example 61)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C25H25N5O2/c1-2-32-20-15-19(23(26)31)29-30-22(17-7-4-3-5-8-17)21(28-24(20)30)16-9-11-18(12-10-16)25(27)13-6-14-25/h3-5,7-12,15H,2,6,13-14,27H2,1H3,(H2,26,31)
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n/an/a 3.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312548
PNG
(US9604989, Example 34)
Show SMILES NC(=O)c1cc(C(N)=O)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N6O2/c25-21(31)17-13-18(22(26)32)29-30-20(15-5-2-1-3-6-15)19(28-23(17)30)14-7-9-16(10-8-14)24(27)11-4-12-24/h1-3,5-10,13H,4,11-12,27H2,(H2,25,31)(H2,26,32)
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n/an/a 3.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312521
PNG
(1-[4-(6,8-Dimethyloxy-3-phenylimidazo[1,2-b]pyrida...)
Show SMILES COc1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4O2/c1-29-19-15-20(30-2)27-28-22(17-7-4-3-5-8-17)21(26-23(19)28)16-9-11-18(12-10-16)24(25)13-6-14-24/h3-5,7-12,15H,6,13-14,25H2,1-2H3
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n/an/a 3.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312575
PNG
(US9604989, Example 61)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C25H25N5O2/c1-2-32-20-15-19(23(26)31)29-30-22(17-7-4-3-5-8-17)21(28-24(20)30)16-9-11-18(12-10-16)25(27)13-6-14-25/h3-5,7-12,15H,2,6,13-14,27H2,1H3,(H2,26,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312522
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-8-methoxy-3-phenyl...)
Show SMILES COc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-16(30)20-15-21(31-2)24-27-22(23(29(24)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312518
PNG
(1-[4-(6-Methyloxy-3-phenylimidazo[1,2-b]pyridazin-...)
Show SMILES COc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4O/c1-28-20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312587
PNG
(1-{4-[6-Methoxy-3-phenyl-8-(1H-pyrazol-3-yl)imidaz...)
Show SMILES COc1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312527
PNG
(US9604989, Example 15)
Show SMILES COc1cc(-c2cn[nH]c2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312578
PNG
(US9604989, Example 64)
Show SMILES CNC(=O)c1cc(OCC2CC2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H29N5O2/c1-30-27(34)22-16-23(35-17-18-8-9-18)26-31-24(25(33(26)32-22)20-6-3-2-4-7-20)19-10-12-21(13-11-19)28(29)14-5-15-28/h2-4,6-7,10-13,16,18H,5,8-9,14-15,17,29H2,1H3,(H,30,34)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312541
PNG
(US9604989, Example 28)
Show SMILES COCCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C26H27N5O3/c1-33-14-15-34-21-16-20(24(27)32)30-31-23(18-6-3-2-4-7-18)22(29-25(21)31)17-8-10-19(11-9-17)26(28)12-5-13-26/h2-4,6-11,16H,5,12-15,28H2,1H3,(H2,27,32)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312517
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H21N5O/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23/h1-3,5-12H,4,13-14,25H2,(H2,24,29)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312541
PNG
(US9604989, Example 28)
Show SMILES COCCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C26H27N5O3/c1-33-14-15-34-21-16-20(24(27)32)30-31-23(18-6-3-2-4-7-18)22(29-25(21)31)17-8-10-19(11-9-17)26(28)12-5-13-26/h2-4,6-11,16H,5,12-15,28H2,1H3,(H2,27,32)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312539
PNG
(US9604989, Example 26)
Show SMILES CNC(=O)c1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O2/c1-27-24(31)19-15-20(32-2)23-28-21(22(30(23)29-19)17-7-4-3-5-8-17)16-9-11-18(12-10-16)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3,(H,27,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312570
PNG
(Methyl 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-8-...)
Show SMILES COC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312519
PNG
(1-[4-(6-Bromo-8-methyloxy-3-phenylimidazo[1,2-b]py...)
Show SMILES COc1cc(Br)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H21BrN4O/c1-29-18-14-19(24)27-28-21(16-6-3-2-4-7-16)20(26-22(18)28)15-8-10-17(11-9-15)23(25)12-5-13-23/h2-4,6-11,14H,5,12-13,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312574
PNG
(US9604989, Example 60)
Show SMILES NC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312534
PNG
(US9604989, Example 22)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)NC
Show InChI InChI=1S/C26H27N5O2/c1-3-33-21-16-20(25(32)28-2)30-31-23(18-8-5-4-6-9-18)22(29-24(21)31)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3,(H,28,32)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312567
PNG
(1-[4-(6-Methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b...)
Show SMILES COc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312519
PNG
(1-[4-(6-Bromo-8-methyloxy-3-phenylimidazo[1,2-b]py...)
Show SMILES COc1cc(Br)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H21BrN4O/c1-29-18-14-19(24)27-28-21(16-6-3-2-4-7-16)20(26-22(18)28)15-8-10-17(11-9-15)23(25)12-5-13-23/h2-4,6-11,14H,5,12-13,25H2,1H3
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n/an/a 9.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312526
PNG
(US9604989, Example 14)
Show SMILES COc1cc(-c2cccnc2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H25N5O/c1-34-24-17-23(21-9-5-16-30-18-21)27-31-25(26(33(27)32-24)20-7-3-2-4-8-20)19-10-12-22(13-11-19)28(29)14-6-15-28/h2-5,7-13,16-18H,6,14-15,29H2,1H3
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n/an/a 9.80n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312539
PNG
(US9604989, Example 26)
Show SMILES CNC(=O)c1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O2/c1-27-24(31)19-15-20(32-2)23-28-21(22(30(23)29-19)17-7-4-3-5-8-17)16-9-11-18(12-10-16)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3,(H,27,31)
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n/an/a 10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312591
PNG
(1-[4-(8-Butoxy-6-ethoxy-3-phenylimidazo[1,2-b]pyri...)
Show SMILES CCCCOc1cc(OCC)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C28H32N4O2/c1-3-5-18-34-23-19-24(33-4-2)31-32-26(21-10-7-6-8-11-21)25(30-27(23)32)20-12-14-22(15-13-20)28(29)16-9-17-28/h6-8,10-15,19H,3-5,9,16-18,29H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312590
PNG
(US9604989, Example 76)
Show SMILES CCOc1cc(OCC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H28N4O2/c1-3-31-21-17-22(32-4-2)29-30-24(19-9-6-5-7-10-19)23(28-25(21)30)18-11-13-20(14-12-18)26(27)15-8-16-26/h5-7,9-14,17H,3-4,8,15-16,27H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312585
PNG
(US9604989, Example 71)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)C(=O)NCCO)-c1cc[nH]n1
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n/an/a 11n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312578
PNG
(US9604989, Example 64)
Show SMILES CNC(=O)c1cc(OCC2CC2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H29N5O2/c1-30-27(34)22-16-23(35-17-18-8-9-18)26-31-24(25(33(26)32-22)20-6-3-2-4-7-20)19-10-12-21(13-11-19)28(29)14-5-15-28/h2-4,6-7,10-13,16,18H,5,8-9,14-15,17,29H2,1H3,(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312568
PNG
(1-{4-[7,8-Dimethyl-6-(methylsulfanyl)-3-phenylimid...)
Show SMILES CSc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4S/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312548
PNG
(US9604989, Example 34)
Show SMILES NC(=O)c1cc(C(N)=O)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N6O2/c25-21(31)17-13-18(22(26)32)29-30-20(15-5-2-1-3-6-15)19(28-23(17)30)14-7-9-16(10-8-14)24(27)11-4-12-24/h1-3,5-10,13H,4,11-12,27H2,(H2,25,31)(H2,26,32)
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n/an/a 14n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312566
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-7,8-dimethyl-3-phe...)
Show SMILES Cc1c(C)c2nc(c(-c3ccccc3)n2nc1C(N)=O)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-15-16(2)24-28-21(17-9-11-19(12-10-17)25(27)13-6-14-25)22(18-7-4-3-5-8-18)30(24)29-20(15)23(26)31/h3-5,7-12H,6,13-14,27H2,1-2H3,(H2,26,31)
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n/an/a 15n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312540
PNG
(US9604989, Example 27)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(ccnn2c1-c1ccccc1)-c1cc[nH]n1
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n/an/a 15n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312531
PNG
(US9604989, Example 19)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(Cl)nn2c1-c1ccccc1)-c1cc[nH]n1
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n/an/a 15n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312576
PNG
(US9604989, Example 62)
Show SMILES CNC(=O)c1cc(-c2ncc[nH]2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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n/an/a 16n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312570
PNG
(Methyl 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-8-...)
Show SMILES COC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312550
PNG
(US9604989, Example 36)
Show SMILES CSc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4S/c1-28-20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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n/an/a 17n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312534
PNG
(US9604989, Example 22)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)NC
Show InChI InChI=1S/C26H27N5O2/c1-3-33-21-16-20(25(32)28-2)30-31-23(18-8-5-4-6-9-18)22(29-24(21)31)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3,(H,28,32)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312517
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H21N5O/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23/h1-3,5-12H,4,13-14,25H2,(H2,24,29)
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312521
PNG
(1-[4-(6,8-Dimethyloxy-3-phenylimidazo[1,2-b]pyrida...)
Show SMILES COc1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4O2/c1-29-19-15-20(30-2)27-28-22(17-7-4-3-5-8-17)21(26-23(19)28)16-9-11-18(12-10-16)24(25)13-6-14-24/h3-5,7-12,15H,6,13-14,25H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312585
PNG
(US9604989, Example 71)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)C(=O)NCCO)-c1cc[nH]n1
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n/an/a 20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312582
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-N-methyl-3-phenyli...)
Show SMILES CNC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H23N5O/c1-26-23(30)19-12-13-20-27-21(22(29(20)28-19)17-6-3-2-4-7-17)16-8-10-18(11-9-16)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3,(H,26,30)
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n/an/a 21n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312524
PNG
(US9604989, Example 12)
Show SMILES COC(=O)c1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H24N4O3/c1-31-20-15-19(24(30)32-2)28-29-22(17-7-4-3-5-8-17)21(27-23(20)29)16-9-11-18(12-10-16)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3
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n/an/a 21n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312589
PNG
(US9604989, Example 75)
Show SMILES COc1cc(-c2ccncc2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H25N5O/c1-34-24-18-23(19-12-16-30-17-13-19)27-31-25(26(33(27)32-24)21-6-3-2-4-7-21)20-8-10-22(11-9-20)28(29)14-5-15-28/h2-4,6-13,16-18H,5,14-15,29H2,1H3
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n/an/a 21n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312590
PNG
(US9604989, Example 76)
Show SMILES CCOc1cc(OCC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H28N4O2/c1-3-31-21-17-22(32-4-2)29-30-24(19-9-6-5-7-10-19)23(28-25(21)30)18-11-13-20(14-12-18)26(27)15-8-16-26/h5-7,9-14,17H,3-4,8,15-16,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312574
PNG
(US9604989, Example 60)
Show SMILES NC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312571
PNG
(US9604989, Example 57)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)OC
Show InChI InChI=1S/C26H26N4O3/c1-3-33-21-16-20(25(31)32-2)29-30-23(18-8-5-4-6-9-18)22(28-24(21)30)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312566
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-7,8-dimethyl-3-phe...)
Show SMILES Cc1c(C)c2nc(c(-c3ccccc3)n2nc1C(N)=O)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-15-16(2)24-28-21(17-9-11-19(12-10-17)25(27)13-6-14-25)22(18-7-4-3-5-8-18)30(24)29-20(15)23(26)31/h3-5,7-12H,6,13-14,27H2,1-2H3,(H2,26,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312564
PNG
(1-[4-(6-Chloro-7,8-dimethyl-3-phenylimidazo[1,2-b]...)
Show SMILES Cc1c(Cl)nn2c(c(nc2c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23ClN4/c1-15-16(2)23-27-20(17-9-11-19(12-10-17)24(26)13-6-14-24)21(29(23)28-22(15)25)18-7-4-3-5-8-18/h3-5,7-12H,6,13-14,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312540
PNG
(US9604989, Example 27)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(ccnn2c1-c1ccccc1)-c1cc[nH]n1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312571
PNG
(US9604989, Example 57)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)OC
Show InChI InChI=1S/C26H26N4O3/c1-3-33-21-16-20(25(31)32-2)29-30-23(18-8-5-4-6-9-18)22(28-24(21)30)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312592
PNG
(1-[4-(6-Ethoxy-3-phenylimidazo[1,2-b]pyridazin-2-y...)
Show SMILES CCOc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4O/c1-2-29-21-14-13-20-26-22(23(28(20)27-21)18-7-4-3-5-8-18)17-9-11-19(12-10-17)24(25)15-6-16-24/h3-5,7-14H,2,6,15-16,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312555
PNG
(US9604989, Example 41)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(Br)nn2c1-c1ccccc1
Show InChI InChI=1S/C22H19BrN4/c23-18-11-12-19-25-20(21(27(19)26-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(24)13-4-14-22/h1-3,5-12H,4,13-14,24H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312568
PNG
(1-{4-[7,8-Dimethyl-6-(methylsulfanyl)-3-phenylimid...)
Show SMILES CSc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4S/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312536
PNG
(US9604989, Example 24)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(Cl)nn2c1-c1ccccc1)-c1ncc[nH]1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312557
PNG
(US9604989, Example 43)
Show SMILES CC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N4O/c1-16(29)20-12-13-21-26-22(23(28(21)27-20)18-6-3-2-4-7-18)17-8-10-19(11-9-17)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312553
PNG
(US9604989, Example 39)
Show SMILES COC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N4O2/c1-30-23(29)19-12-13-20-26-21(22(28(20)27-19)17-6-3-2-4-7-17)16-8-10-18(11-9-16)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312524
PNG
(US9604989, Example 12)
Show SMILES COC(=O)c1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H24N4O3/c1-31-20-15-19(24(30)32-2)28-29-22(17-7-4-3-5-8-17)21(27-23(20)29)16-9-11-18(12-10-16)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312525
PNG
(US9604989, Example 13)
Show SMILES CCc1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H26N4O/c1-3-20-16-21(30-2)24-27-22(23(29(24)28-20)18-8-5-4-6-9-18)17-10-12-19(13-11-17)25(26)14-7-15-25/h4-6,8-13,16H,3,7,14-15,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312565
PNG
(Methyl 2-[4-(1-aminocyclobutyl)phenyl]-7,8-dimethy...)
Show SMILES COC(=O)c1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c1-16-17(2)24-28-22(18-10-12-20(13-11-18)26(27)14-7-15-26)23(19-8-5-4-6-9-19)30(24)29-21(16)25(31)32-3/h4-6,8-13H,7,14-15,27H2,1-3H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312531
PNG
(US9604989, Example 19)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(Cl)nn2c1-c1ccccc1)-c1cc[nH]n1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312529
PNG
(1-[4-(6-Chloro-3-phenylimidazo[1,2-b]pyridazin-2-y...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(Cl)nn2c1-c1ccccc1
Show InChI InChI=1S/C22H19ClN4/c23-18-11-12-19-25-20(21(27(19)26-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(24)13-4-14-22/h1-3,5-12H,4,13-14,24H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312587
PNG
(1-{4-[6-Methoxy-3-phenyl-8-(1H-pyrazol-3-yl)imidaz...)
Show SMILES COc1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312564
PNG
(1-[4-(6-Chloro-7,8-dimethyl-3-phenylimidazo[1,2-b]...)
Show SMILES Cc1c(Cl)nn2c(c(nc2c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23ClN4/c1-15-16(2)23-27-20(17-9-11-19(12-10-17)24(26)13-6-14-24)21(29(23)28-22(15)25)18-7-4-3-5-8-18/h3-5,7-12H,6,13-14,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312569
PNG
(1-[4-(6-Ethoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]...)
Show SMILES CCOc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H28N4O/c1-4-31-25-18(3)17(2)24-28-22(23(30(24)29-25)20-9-6-5-7-10-20)19-11-13-21(14-12-19)26(27)15-8-16-26/h5-7,9-14H,4,8,15-16,27H2,1-3H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312577
PNG
(US9604989, Example 63)
Show SMILES CNC(=O)c1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O/c1-26-23(30)19-12-15-27-29-21(17-6-3-2-4-7-17)20(28-22(19)29)16-8-10-18(11-9-16)24(25)13-5-14-24/h2-4,6-12,15H,5,13-14,25H2,1H3,(H,26,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312544
PNG
(US9604989, Example 31)
Show SMILES COC(=O)c1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H22N4O2/c1-30-23(29)19-12-15-26-28-21(17-6-3-2-4-7-17)20(27-22(19)28)16-8-10-18(11-9-16)24(25)13-5-14-24/h2-4,6-12,15H,5,13-14,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312543
PNG
(US9604989, Example 30)
Show SMILES CCOc1cc(Cl)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23ClN4O/c1-2-30-19-15-20(25)28-29-22(17-7-4-3-5-8-17)21(27-23(19)29)16-9-11-18(12-10-16)24(26)13-6-14-24/h3-5,7-12,15H,2,6,13-14,26H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312580
PNG
(US9604989, Example 66)
Show SMILES CCNC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-2-27-24(31)20-13-14-21-28-22(23(30(21)29-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)15-6-16-25/h3-5,7-14H,2,6,15-16,26H2,1H3,(H,27,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312530
PNG
(1-[4-(8-Methoxy-3-phenyl-6-vinylimidazo[1,2-b]pyri...)
Show SMILES COc1cc(C=C)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O/c1-3-20-16-21(30-2)24-27-22(23(29(24)28-20)18-8-5-4-6-9-18)17-10-12-19(13-11-17)25(26)14-7-15-25/h3-6,8-13,16H,1,7,14-15,26H2,2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312550
PNG
(US9604989, Example 36)
Show SMILES CSc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4S/c1-28-20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312542
PNG
(US9604989, Example 29)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(OCc3ccccc3)cc(Cl)nn2c1-c1ccccc1
Show InChI InChI=1S/C29H25ClN4O/c30-25-18-24(35-19-20-8-3-1-4-9-20)28-32-26(27(34(28)33-25)22-10-5-2-6-11-22)21-12-14-23(15-13-21)29(31)16-7-17-29/h1-6,8-15,18H,7,16-17,19,31H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312569
PNG
(1-[4-(6-Ethoxy-7,8-dimethyl-3-phenylimidazo[1,2-b]...)
Show SMILES CCOc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H28N4O/c1-4-31-25-18(3)17(2)24-28-22(23(30(24)29-25)20-9-6-5-7-10-20)19-11-13-21(14-12-19)26(27)15-8-16-26/h5-7,9-14H,4,8,15-16,27H2,1-3H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312527
PNG
(US9604989, Example 15)
Show SMILES COc1cc(-c2cn[nH]c2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312581
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenyl-8-(1H-pyr...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)C(O)=O)-c1cc[nH]n1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312543
PNG
(US9604989, Example 30)
Show SMILES CCOc1cc(Cl)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23ClN4O/c1-2-30-19-15-20(25)28-29-22(17-7-4-3-5-8-17)21(27-23(19)29)16-9-11-18(12-10-16)24(26)13-6-14-24/h3-5,7-12,15H,2,6,13-14,26H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312591
PNG
(1-[4-(8-Butoxy-6-ethoxy-3-phenylimidazo[1,2-b]pyri...)
Show SMILES CCCCOc1cc(OCC)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C28H32N4O2/c1-3-5-18-34-23-19-24(33-4-2)31-32-26(21-10-7-6-8-11-21)25(30-27(23)32)20-12-14-22(15-13-20)28(29)16-9-17-28/h6-8,10-15,19H,3-5,9,16-18,29H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312576
PNG
(US9604989, Example 62)
Show SMILES CNC(=O)c1cc(-c2ncc[nH]2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312514
PNG
(1-[4-(6-Ethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl...)
Show SMILES CCc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4/c1-2-20-13-14-21-26-22(23(28(21)27-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)24(25)15-6-16-24/h3-5,7-14H,2,6,15-16,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312573
PNG
(US9604989, Example 59 | tert-Butyl {1-[4-(8-acetam...)
Show SMILES NC(=O)c1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O/c24-21(29)18-11-14-26-28-20(16-5-2-1-3-6-16)19(27-22(18)28)15-7-9-17(10-8-15)23(25)12-4-13-23/h1-3,5-11,14H,4,12-13,25H2,(H2,24,29)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312526
PNG
(US9604989, Example 14)
Show SMILES COc1cc(-c2cccnc2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H25N5O/c1-34-24-17-23(21-9-5-16-30-18-21)27-31-25(26(33(27)32-24)20-7-3-2-4-8-20)19-10-12-22(13-11-19)28(29)14-6-15-28/h2-5,7-13,16-18H,6,14-15,29H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312555
PNG
(US9604989, Example 41)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(Br)nn2c1-c1ccccc1
Show InChI InChI=1S/C22H19BrN4/c23-18-11-12-19-25-20(21(27(19)26-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(24)13-4-14-22/h1-3,5-12H,4,13-14,24H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312582
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-N-methyl-3-phenyli...)
Show SMILES CNC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H23N5O/c1-26-23(30)19-12-13-20-27-21(22(29(20)28-19)17-6-3-2-4-7-17)16-8-10-18(11-9-16)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3,(H,26,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312563
PNG
(US9604989, Example 49)
Show SMILES CC(=O)Nc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O/c1-16(30)27-20-12-15-26-29-22(18-6-3-2-4-7-18)21(28-23(20)29)17-8-10-19(11-9-17)24(25)13-5-14-24/h2-4,6-12,15H,5,13-14,25H2,1H3,(H,27,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312515
PNG
(1-{4-[3-Phenyl-6-(trifluoromethyl)imidazo[1,2-b]py...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(nn2c1-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N4/c24-23(25,26)18-11-12-19-28-20(21(30(19)29-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(27)13-4-14-22/h1-3,5-12H,4,13-14,27H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312533
PNG
(US9604989, Example 21)
Show SMILES CCc1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312525
PNG
(US9604989, Example 13)
Show SMILES CCc1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H26N4O/c1-3-20-16-21(30-2)24-27-22(23(29(24)28-20)18-8-5-4-6-9-18)17-10-12-19(13-11-17)25(26)14-7-15-25/h4-6,8-13,16H,3,7,14-15,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312542
PNG
(US9604989, Example 29)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(OCc3ccccc3)cc(Cl)nn2c1-c1ccccc1
Show InChI InChI=1S/C29H25ClN4O/c30-25-18-24(35-19-20-8-3-1-4-9-20)28-32-26(27(34(28)33-25)22-10-5-2-6-11-22)21-12-14-23(15-13-21)29(31)16-7-17-29/h1-6,8-15,18H,7,16-17,19,31H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312518
PNG
(1-[4-(6-Methyloxy-3-phenylimidazo[1,2-b]pyridazin-...)
Show SMILES COc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4O/c1-28-20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312536
PNG
(US9604989, Example 24)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(Cl)nn2c1-c1ccccc1)-c1ncc[nH]1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312565
PNG
(Methyl 2-[4-(1-aminocyclobutyl)phenyl]-7,8-dimethy...)
Show SMILES COC(=O)c1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H26N4O2/c1-16-17(2)24-28-22(18-10-12-20(13-11-18)26(27)14-7-15-26)23(19-8-5-4-6-9-19)30(24)29-21(16)25(31)32-3/h4-6,8-13H,7,14-15,27H2,1-3H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312560
PNG
(US9604989, Example 46)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(Cl)nn2c1-c1ccccc1)C1CC1
Show InChI InChI=1S/C25H23ClN4/c26-21-15-20(16-7-8-16)24-28-22(23(30(24)29-21)18-5-2-1-3-6-18)17-9-11-19(12-10-17)25(27)13-4-14-25/h1-3,5-6,9-12,15-16H,4,7-8,13-14,27H2
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n/an/a 85n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312516
PNG
(Ethyl 2-[4-(1-aminocyclobutyl)phenyl]-3-phenylimid...)
Show SMILES CCOC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H24N4O2/c1-2-31-24(30)20-13-14-21-27-22(23(29(21)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)15-6-16-25/h3-5,7-14H,2,6,15-16,26H2,1H3
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n/an/a 85n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312530
PNG
(1-[4-(8-Methoxy-3-phenyl-6-vinylimidazo[1,2-b]pyri...)
Show SMILES COc1cc(C=C)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H24N4O/c1-3-20-16-21(30-2)24-27-22(23(29(24)28-20)18-8-5-4-6-9-18)17-10-12-19(13-11-17)25(26)14-7-15-25/h3-6,8-13,16H,1,7,14-15,26H2,2H3
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n/an/a 86n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312529
PNG
(1-[4-(6-Chloro-3-phenylimidazo[1,2-b]pyridazin-2-y...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(Cl)nn2c1-c1ccccc1
Show InChI InChI=1S/C22H19ClN4/c23-18-11-12-19-25-20(21(27(19)26-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(24)13-4-14-22/h1-3,5-12H,4,13-14,24H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312588
PNG
(US9604989, Example 74)
Show SMILES COc1cc(-c2ccnn2C)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C27H26N6O/c1-32-22(13-16-29-32)21-17-23(34-2)31-33-25(19-7-4-3-5-8-19)24(30-26(21)33)18-9-11-20(12-10-18)27(28)14-6-15-27/h3-5,7-13,16-17H,6,14-15,28H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312594
PNG
(Methyl ({2-[4-(1-aminocyclobutyl)phenyl]-3-phenyli...)
Show SMILES COC(=O)COc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H24N4O3/c1-31-22(30)16-32-21-13-12-20-27-23(24(29(20)28-21)18-6-3-2-4-7-18)17-8-10-19(11-9-17)25(26)14-5-15-25/h2-4,6-13H,5,14-16,26H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312581
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenyl-8-(1H-pyr...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)C(O)=O)-c1cc[nH]n1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312514
PNG
(1-[4-(6-Ethyl-3-phenylimidazo[1,2-b]pyridazin-2-yl...)
Show SMILES CCc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4/c1-2-20-13-14-21-26-22(23(28(21)27-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)24(25)15-6-16-24/h3-5,7-14H,2,6,15-16,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312589
PNG
(US9604989, Example 75)
Show SMILES COc1cc(-c2ccncc2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H25N5O/c1-34-24-18-23(19-12-16-30-17-13-19)27-31-25(26(33(27)32-24)21-6-3-2-4-7-21)20-8-10-22(11-9-20)28(29)14-5-15-28/h2-4,6-13,16-18H,5,14-15,29H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312523
PNG
(1-[4-(8-Methoxy-3-phenylimidazo[1,2-b]pyridazin-2-...)
Show SMILES COc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H22N4O/c1-28-19-12-15-25-27-21(17-6-3-2-4-7-17)20(26-22(19)27)16-8-10-18(11-9-16)23(24)13-5-14-23/h2-4,6-12,15H,5,13-14,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312573
PNG
(US9604989, Example 59 | tert-Butyl {1-[4-(8-acetam...)
Show SMILES NC(=O)c1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O/c24-21(29)18-11-14-26-28-20(16-5-2-1-3-6-16)19(27-22(18)28)15-7-9-17(10-8-15)23(25)12-4-13-23/h1-3,5-11,14H,4,12-13,25H2,(H2,24,29)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312584
PNG
(US9604989, Example 70)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(nn2c1-c1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C25H25N5O2/c26-25(13-4-14-25)19-9-7-17(8-10-19)22-23(18-5-2-1-3-6-18)30-21(28-22)12-11-20(29-30)24(32)27-15-16-31/h1-3,5-12,31H,4,13-16,26H2,(H,27,32)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312560
PNG
(US9604989, Example 46)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(Cl)nn2c1-c1ccccc1)C1CC1
Show InChI InChI=1S/C25H23ClN4/c26-21-15-20(16-7-8-16)24-28-22(23(30(24)29-21)18-5-2-1-3-6-18)17-9-11-19(12-10-17)25(27)13-4-14-25/h1-3,5-6,9-12,15-16H,4,7-8,13-14,27H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312572
PNG
(US9604989, Example 58)
Show SMILES COC(=O)c1cc(-c2ncc[nH]2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312557
PNG
(US9604989, Example 43)
Show SMILES CC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N4O/c1-16(29)20-12-13-21-26-22(23(28(21)27-20)18-6-3-2-4-7-18)17-8-10-19(11-9-17)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312577
PNG
(US9604989, Example 63)
Show SMILES CNC(=O)c1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O/c1-26-23(30)19-12-15-27-29-21(17-6-3-2-4-7-17)20(28-22(19)29)16-8-10-18(11-9-16)24(25)13-5-14-24/h2-4,6-12,15H,5,13-14,25H2,1H3,(H,26,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312563
PNG
(US9604989, Example 49)
Show SMILES CC(=O)Nc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23N5O/c1-16(30)27-20-12-15-26-29-22(18-6-3-2-4-7-18)21(28-23(20)29)17-8-10-19(11-9-17)24(25)13-5-14-24/h2-4,6-12,15H,5,13-14,25H2,1H3,(H,27,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312532
PNG
(US9604989, Example 20)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(C=C)nn2c1-c1ccccc1)-c1cc[nH]n1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312515
PNG
(1-{4-[3-Phenyl-6-(trifluoromethyl)imidazo[1,2-b]py...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(nn2c1-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C23H19F3N4/c24-23(25,26)18-11-12-19-28-20(21(30(19)29-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(27)13-4-14-22/h1-3,5-12H,4,13-14,27H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312588
PNG
(US9604989, Example 74)
Show SMILES COc1cc(-c2ccnn2C)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C27H26N6O/c1-32-22(13-16-29-32)21-17-23(34-2)31-33-25(19-7-4-3-5-8-19)24(30-26(21)33)18-9-11-20(12-10-18)27(28)14-6-15-27/h3-5,7-13,16-17H,6,14-15,28H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312533
PNG
(US9604989, Example 21)
Show SMILES CCc1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312584
PNG
(US9604989, Example 70)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(nn2c1-c1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C25H25N5O2/c26-25(13-4-14-25)19-9-7-17(8-10-19)22-23(18-5-2-1-3-6-18)30-21(28-22)12-11-20(29-30)24(32)27-15-16-31/h1-3,5-12,31H,4,13-16,26H2,(H,27,32)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312523
PNG
(1-[4-(8-Methoxy-3-phenylimidazo[1,2-b]pyridazin-2-...)
Show SMILES COc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H22N4O/c1-28-19-12-15-25-27-21(17-6-3-2-4-7-17)20(26-22(19)27)16-8-10-18(11-9-16)23(24)13-5-14-23/h2-4,6-12,15H,5,13-14,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312552
PNG
(US9604989, Example 38)
Show SMILES CS(=O)(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4O2S/c1-30(28,29)20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312544
PNG
(US9604989, Example 31)
Show SMILES COC(=O)c1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H22N4O2/c1-30-23(29)19-12-15-26-28-21(17-6-3-2-4-7-17)20(27-22(19)28)16-8-10-18(11-9-16)24(25)13-5-14-24/h2-4,6-12,15H,5,13-14,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312553
PNG
(US9604989, Example 39)
Show SMILES COC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N4O2/c1-30-23(29)19-12-13-20-26-21(22(28(20)27-19)17-6-3-2-4-7-17)16-8-10-18(11-9-16)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312528
PNG
(US9604989, Example 16)
Show SMILES CCc1cc(CC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H28N4/c1-3-18-17-22(4-2)29-30-24(20-9-6-5-7-10-20)23(28-25(18)30)19-11-13-21(14-12-19)26(27)15-8-16-26/h5-7,9-14,17H,3-4,8,15-16,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312528
PNG
(US9604989, Example 16)
Show SMILES CCc1cc(CC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H28N4/c1-3-18-17-22(4-2)29-30-24(20-9-6-5-7-10-20)23(28-25(18)30)19-11-13-21(14-12-19)26(27)15-8-16-26/h5-7,9-14,17H,3-4,8,15-16,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312537
PNG
(US9604989, Example 25)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2cccnn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4/c23-22(13-5-14-22)18-11-9-16(10-12-18)20-21(17-6-2-1-3-7-17)26-19(25-20)8-4-15-24-26/h1-4,6-12,15H,5,13-14,23H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312532
PNG
(US9604989, Example 20)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(C=C)nn2c1-c1ccccc1)-c1cc[nH]n1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312513
PNG
(1-[4-(6-Methyl-3-phenylimidazo[1,2-b]pyridazin-2-y...)
Show SMILES Cc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4/c1-16-8-13-20-25-21(22(27(20)26-16)18-6-3-2-4-7-18)17-9-11-19(12-10-17)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312580
PNG
(US9604989, Example 66)
Show SMILES CCNC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-2-27-24(31)20-13-14-21-28-22(23(30(21)29-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)15-6-16-25/h3-5,7-14H,2,6,15-16,26H2,1H3,(H,27,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312562
PNG
(US9604989, Example 48)
Show SMILES Nc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C22H21N5/c23-18-11-14-25-27-20(16-5-2-1-3-6-16)19(26-21(18)27)15-7-9-17(10-8-15)22(24)12-4-13-22/h1-3,5-11,14H,4,12-13,23-24H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312558
PNG
(US9604989, Example 44)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(ccnn2c1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN4/c29-23-13-9-19(10-14-23)24-15-18-31-33-26(21-5-2-1-3-6-21)25(32-27(24)33)20-7-11-22(12-8-20)28(30)16-4-17-28/h1-3,5-15,18H,4,16-17,30H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312535
PNG
(US9604989, Example 23)
Show SMILES Cn1nccc1-c1cc(Cl)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H23ClN6/c1-32-21(12-15-29-32)20-16-22(27)31-33-24(18-6-3-2-4-7-18)23(30-25(20)33)17-8-10-19(11-9-17)26(28)13-5-14-26/h2-4,6-12,15-16H,5,13-14,28H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312537
PNG
(US9604989, Example 25)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2cccnn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4/c23-22(13-5-14-22)18-11-9-16(10-12-18)20-21(17-6-2-1-3-7-17)26-19(25-20)8-4-15-24-26/h1-4,6-12,15H,5,13-14,23H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312516
PNG
(Ethyl 2-[4-(1-aminocyclobutyl)phenyl]-3-phenylimid...)
Show SMILES CCOC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H24N4O2/c1-2-31-24(30)20-13-14-21-27-22(23(29(21)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)15-6-16-25/h3-5,7-14H,2,6,15-16,26H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312561
PNG
(US9604989, Example 47)
Show SMILES CCCc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4/c1-2-7-20-14-17-27-29-23(19-8-4-3-5-9-19)22(28-24(20)29)18-10-12-21(13-11-18)25(26)15-6-16-25/h3-5,8-14,17H,2,6-7,15-16,26H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312592
PNG
(1-[4-(6-Ethoxy-3-phenylimidazo[1,2-b]pyridazin-2-y...)
Show SMILES CCOc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4O/c1-2-29-21-14-13-20-26-22(23(28(20)27-21)18-7-4-3-5-8-18)17-9-11-19(12-10-17)24(25)15-6-16-24/h3-5,7-14H,2,6,15-16,25H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312572
PNG
(US9604989, Example 58)
Show SMILES COC(=O)c1cc(-c2ncc[nH]2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312583
PNG
(US9604989, Example 69)
Show SMILES CN(C)C(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-29(2)24(31)20-13-14-21-27-22(23(30(21)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)15-6-16-25/h3-5,7-14H,6,15-16,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312586
PNG
( Methyl 3-{2-[4-(1-aminocyclobutyl)phenyl]-3-pheny...)
Show SMILES COC(=O)\C=C\c1cc(Br)nn2c(c(nc12)-c1ccc(cc1)C1(CCC1)NC(=O)OC(C)(C)C)-c1ccccc1
Show InChI InChI=1S/C31H31BrN4O4/c1-30(2,3)40-29(38)34-31(17-8-18-31)23-14-11-20(12-15-23)26-27(21-9-6-5-7-10-21)36-28(33-26)22(19-24(32)35-36)13-16-25(37)39-4/h5-7,9-16,19H,8,17-18H2,1-4H3,(H,34,38)/b16-13+
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312558
PNG
(US9604989, Example 44)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(ccnn2c1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN4/c29-23-13-9-19(10-14-23)24-15-18-31-33-26(21-5-2-1-3-6-21)25(32-27(24)33)20-7-11-22(12-8-20)28(30)16-4-17-28/h1-3,5-15,18H,4,16-17,30H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312561
PNG
(US9604989, Example 47)
Show SMILES CCCc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4/c1-2-7-20-14-17-27-29-23(19-8-4-3-5-9-19)22(28-24(20)29)18-10-12-21(13-11-18)25(26)15-6-16-25/h3-5,8-14,17H,2,6-7,15-16,26H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312549
PNG
(US9604989, Example 35)
Show SMILES Nc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C22H21N5/c23-18-11-12-19-25-20(21(27(19)26-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(24)13-4-14-22/h1-3,5-12H,4,13-14,24H2,(H2,23,26)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312552
PNG
(US9604989, Example 38)
Show SMILES CS(=O)(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4O2S/c1-30(28,29)20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312513
PNG
(1-[4-(6-Methyl-3-phenylimidazo[1,2-b]pyridazin-2-y...)
Show SMILES Cc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4/c1-16-8-13-20-25-21(22(27(20)26-16)18-6-3-2-4-7-18)17-9-11-19(12-10-17)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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n/an/a 380n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312520
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(nn2c1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H20N4O2/c24-23(13-4-14-23)17-9-7-15(8-10-17)20-21(16-5-2-1-3-6-16)27-19(25-20)12-11-18(26-27)22(28)29/h1-3,5-12H,4,13-14,24H2,(H,28,29)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312520
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(nn2c1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H20N4O2/c24-23(13-4-14-23)17-9-7-15(8-10-17)20-21(16-5-2-1-3-6-16)27-19(25-20)12-11-18(26-27)22(28)29/h1-3,5-12H,4,13-14,24H2,(H,28,29)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312551
PNG
(US9604989, Example 37)
Show SMILES CC(=O)Nc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H23N5O/c1-16(30)26-20-12-13-21-27-22(23(29(21)28-20)18-6-3-2-4-7-18)17-8-10-19(11-9-17)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3,(H,26,28,30)
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n/an/a 510n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312551
PNG
(US9604989, Example 37)
Show SMILES CC(=O)Nc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H23N5O/c1-16(30)26-20-12-13-21-27-22(23(29(21)28-20)18-6-3-2-4-7-18)17-8-10-19(11-9-17)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3,(H,26,28,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312586
PNG
( Methyl 3-{2-[4-(1-aminocyclobutyl)phenyl]-3-pheny...)
Show SMILES COC(=O)\C=C\c1cc(Br)nn2c(c(nc12)-c1ccc(cc1)C1(CCC1)NC(=O)OC(C)(C)C)-c1ccccc1
Show InChI InChI=1S/C31H31BrN4O4/c1-30(2,3)40-29(38)34-31(17-8-18-31)23-14-11-20(12-15-23)26-27(21-9-6-5-7-10-21)36-28(33-26)22(19-24(32)35-36)13-16-25(37)39-4/h5-7,9-16,19H,8,17-18H2,1-4H3,(H,34,38)/b16-13+
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312594
PNG
(Methyl ({2-[4-(1-aminocyclobutyl)phenyl]-3-phenyli...)
Show SMILES COC(=O)COc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H24N4O3/c1-31-22(30)16-32-21-13-12-20-27-23(24(29(20)28-21)18-6-3-2-4-7-18)17-8-10-19(11-9-17)25(26)14-5-15-25/h2-4,6-13H,5,14-16,26H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312562
PNG
(US9604989, Example 48)
Show SMILES Nc1ccnn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C22H21N5/c23-18-11-14-25-27-20(16-5-2-1-3-6-16)19(26-21(18)27)15-7-9-17(10-8-15)22(24)12-4-13-22/h1-3,5-11,14H,4,12-13,23-24H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312546
PNG
(US9604989, Example 33)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(nn2c1-c1ccccc1)-c1ccc(F)cc1
Show InChI InChI=1S/C28H23FN4/c29-23-13-9-19(10-14-23)24-15-16-25-31-26(27(33(25)32-24)21-5-2-1-3-6-21)20-7-11-22(12-8-20)28(30)17-4-18-28/h1-3,5-16H,4,17-18,30H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312583
PNG
(US9604989, Example 69)
Show SMILES CN(C)C(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-29(2)24(31)20-13-14-21-27-22(23(30(21)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)15-6-16-25/h3-5,7-14H,6,15-16,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312549
PNG
(US9604989, Example 35)
Show SMILES Nc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C22H21N5/c23-18-11-12-19-25-20(21(27(19)26-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)22(24)13-4-14-22/h1-3,5-12H,4,13-14,24H2,(H2,23,26)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312559
PNG
(US9604989, Example 45)
Show SMILES CS(=O)(=O)Nc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H23N5O2S/c1-31(29,30)27-19-12-13-20-25-21(22(28(20)26-19)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3,(H,26,27)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312535
PNG
(US9604989, Example 23)
Show SMILES Cn1nccc1-c1cc(Cl)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C26H23ClN6/c1-32-21(12-15-29-32)20-16-22(27)31-33-24(18-6-3-2-4-7-18)23(30-25(20)33)17-8-10-19(11-9-17)26(28)13-5-14-26/h2-4,6-12,15-16H,5,13-14,28H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312554
PNG
(US9604989, Example 40)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(NC(=O)C(F)(F)F)nn2c1-c1ccccc1
Show InChI InChI=1S/C24H20F3N5O/c25-24(26,27)22(33)29-18-11-12-19-30-20(21(32(19)31-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(28)13-4-14-23/h1-3,5-12H,4,13-14,28H2,(H,29,31,33)
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n/an/a 1.40E+3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312554
PNG
(US9604989, Example 40)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(NC(=O)C(F)(F)F)nn2c1-c1ccccc1
Show InChI InChI=1S/C24H20F3N5O/c25-24(26,27)22(33)29-18-11-12-19-30-20(21(32(19)31-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(28)13-4-14-23/h1-3,5-12H,4,13-14,28H2,(H,29,31,33)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312593
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(O)nn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4O/c23-22(13-4-14-22)17-9-7-15(8-10-17)20-21(16-5-2-1-3-6-16)26-18(24-20)11-12-19(27)25-26/h1-3,5-12H,4,13-14,23H2,(H,25,27)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312593
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2ccc(O)nn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4O/c23-22(13-4-14-22)17-9-7-15(8-10-17)20-21(16-5-2-1-3-6-16)26-18(24-20)11-12-19(27)25-26/h1-3,5-12H,4,13-14,23H2,(H,25,27)
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n/an/a 2.80E+3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312545
PNG
(US9604989, Example 32)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(O)ccnn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4O/c23-22(12-4-13-22)17-9-7-15(8-10-17)19-20(16-5-2-1-3-6-16)26-21(25-19)18(27)11-14-24-26/h1-3,5-11,14,27H,4,12-13,23H2
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312545
PNG
(US9604989, Example 32)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(O)ccnn2c1-c1ccccc1
Show InChI InChI=1S/C22H20N4O/c23-22(12-4-13-22)17-9-7-15(8-10-17)19-20(16-5-2-1-3-6-16)26-21(25-19)18(27)11-14-24-26/h1-3,5-11,14,27H,4,12-13,23H2
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n/an/a 3.70E+3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312559
PNG
(US9604989, Example 45)
Show SMILES CS(=O)(=O)Nc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H23N5O2S/c1-31(29,30)27-19-12-13-20-25-21(22(28(20)26-19)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3,(H,26,27)
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n/an/a 6.60E+3n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312556
PNG
(US9604989, Example 42)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)-c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H26F2N4/c35-27-15-9-22(10-16-27)29-21-30(23-11-17-28(36)18-12-23)39-40-32(25-5-2-1-3-6-25)31(38-33(29)40)24-7-13-26(14-8-24)34(37)19-4-20-34/h1-3,5-18,21H,4,19-20,37H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312556
PNG
(US9604989, Example 42)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)-c1ccc(F)cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C34H26F2N4/c35-27-15-9-22(10-16-27)29-21-30(23-11-17-28(36)18-12-23)39-40-32(25-5-2-1-3-6-25)31(38-33(29)40)24-7-13-26(14-8-24)34(37)19-4-20-34/h1-3,5-18,21H,4,19-20,37H2
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 2.00E+4n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%