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Patent code US9605005

Compile Data Set for Download or QSAR
Found 199 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312801
PNG
(7-cyano-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C#N)C1=O
Show InChI InChI=1S/C22H17N5O3/c1-26-10-8-22(30,21(26)29)7-5-14-3-2-4-16(11-14)18-17-12-15(13-23)6-9-27(17)20(25-18)19(24)28/h2-4,6,9,11-12,30H,8,10H2,1H3,(H2,24,28)/t22-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312788
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O3/c1-24-12-10-21(28,20(24)27)9-8-14-5-4-6-15(13-14)17-16-7-2-3-11-25(16)19(23-17)18(22)26/h2-7,11,13,28H,10,12H2,1H3,(H2,22,26)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312899
PNG
(6-fluoro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(F)cc23)C1=O
Show InChI InChI=1S/C21H17FN4O3/c1-25-10-9-21(29,20(25)28)8-7-13-3-2-4-15(11-13)26-17-12-14(22)5-6-16(17)18(24-26)19(23)27/h2-6,11-12,29H,9-10H2,1H3,(H2,23,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312905
PNG
(5-amino-2-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c(N)s2)C1=O
Show InChI InChI=1S/C17H16N4O3S/c1-21-8-7-17(24,16(21)23)6-5-10-3-2-4-11(9-10)15-20-12(13(18)22)14(19)25-15/h2-4,9,24H,7-8,19H2,1H3,(H2,18,22)/t17-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312785
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cnc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H19N5O4/c1-25-9-8-21(29,20(25)28)7-6-13-4-3-5-14(10-13)26-19-16(17(24-26)18(22)27)11-15(30-2)12-23-19/h3-5,10-12,29H,8-9H2,1-2H3,(H2,22,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312808
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccn2c(nc(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2c1)C(N)=O
Show InChI InChI=1S/C22H20N4O4/c1-25-11-9-22(29,21(25)28)8-6-14-4-3-5-15(12-14)18-17-13-16(30-2)7-10-26(17)20(24-18)19(23)27/h3-5,7,10,12-13,29H,9,11H2,1-2H3,(H2,23,27)/t22-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312809
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2c(nc(C(N)=O)n2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C22H20N4O4/c1-25-11-10-22(29,21(25)28)9-8-14-4-3-5-15(12-14)18-17-7-6-16(30-2)13-26(17)20(24-18)19(23)27/h3-7,12-13,29H,10-11H2,1-2H3,(H2,23,27)/t22-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312816
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)-n2cnc(C)c2)C1=O
Show InChI InChI=1S/C25H22N6O3/c1-16-14-30(15-27-16)18-6-7-21-20(13-18)22(23(26)32)28-31(21)19-5-3-4-17(12-19)8-9-25(34)10-11-29(2)24(25)33/h3-7,12-15,34H,10-11H2,1-2H3,(H2,26,32)/t25-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312885
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(C)nc23)C1=O
Show InChI InChI=1S/C21H19N5O3/c1-13-6-7-16-17(18(22)27)24-26(19(16)23-13)15-5-3-4-14(12-15)8-9-21(29)10-11-25(2)20(21)28/h3-7,12,29H,10-11H2,1-2H3,(H2,22,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312806
PNG
(1,7-bis[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)-c2cccc(c2)C#C[C@]2(O)CCN(C)C2=O)C1=O
Show InChI InChI=1S/C34H29N5O5/c1-37-17-14-33(43,31(37)41)12-9-22-5-3-7-24(19-22)25-11-16-39-27(21-25)28(36-30(39)29(35)40)26-8-4-6-23(20-26)10-13-34(44)15-18-38(2)32(34)42/h3-8,11,16,19-21,43-44H,14-15,17-18H2,1-2H3,(H2,35,40)/t33-,34-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312776
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2n(nc(C(N)=O)c2c1)-c1cc(ccn1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H19N5O4/c1-25-10-8-21(29,20(25)28)7-5-13-6-9-23-17(11-13)26-16-4-3-14(30-2)12-15(16)18(24-26)19(22)27/h3-4,6,9,11-12,29H,8,10H2,1-2H3,(H2,22,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312787
PNG
(6-chloro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(Cl)cc23)C1=O
Show InChI InChI=1S/C20H16ClN5O3/c1-25-8-7-20(29,19(25)28)6-5-12-3-2-4-13(9-12)26-15-10-16(21)23-11-14(15)17(24-26)18(22)27/h2-4,9-11,29H,7-8H2,1H3,(H2,22,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312796
PNG
(8-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3cccnc23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-11-8-20(28,19(24)27)7-6-13-4-2-5-14(12-13)15-17-22-9-3-10-25(17)18(23-15)16(21)26/h2-5,9-10,12,28H,8,11H2,1H3,(H2,21,26)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312805
PNG
(7-chloro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(Cl)cc23)C1=O
Show InChI InChI=1S/C21H17ClN4O3/c1-25-10-8-21(29,20(25)28)7-5-13-3-2-4-14(11-13)17-16-12-15(22)6-9-26(16)19(24-17)18(23)27/h2-4,6,9,11-12,29H,8,10H2,1H3,(H2,23,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312850
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cc2n(nc(C(N)=O)c2cn1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H19N5O4/c1-25-9-8-21(29,20(25)28)7-6-13-4-3-5-14(10-13)26-16-11-17(30-2)23-12-15(16)18(24-26)19(22)27/h3-5,10-12,29H,8-9H2,1-2H3,(H2,22,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312724
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C22H20N4O4/c1-25-11-10-22(29,21(25)28)9-8-14-4-3-5-15(12-14)26-18-7-6-16(30-2)13-17(18)19(24-26)20(23)27/h3-7,12-13,29H,10-11H2,1-2H3,(H2,23,27)/t22-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312904
PNG
((5R)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES C[C@@H]1Cc2c(C1)n(nc2C(N)=O)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H22N4O3/c1-13-10-16-17(11-13)25(23-18(16)19(22)26)15-5-3-4-14(12-15)6-7-21(28)8-9-24(2)20(21)27/h3-5,12-13,28H,8-11H2,1-2H3,(H2,22,26)/t13-,21+/m1/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312760
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CNc1nccc2n(nc(C(N)=O)c12)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H20N6O3/c1-23-19-16-15(7-10-24-19)27(25-17(16)18(22)28)14-5-3-4-13(12-14)6-8-21(30)9-11-26(2)20(21)29/h3-5,7,10,12,30H,9,11H2,1-2H3,(H2,22,28)(H,23,24)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312906
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CNc1nc2n(nc(C(N)=O)c2s1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C19H18N6O3S/c1-21-18-22-16-14(29-18)13(15(20)26)23-25(16)12-5-3-4-11(10-12)6-7-19(28)8-9-24(2)17(19)27/h3-5,10,28H,8-9H2,1-2H3,(H2,20,26)(H,21,22)/t19-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312864
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2n1)C(N)=O
Show InChI InChI=1S/C21H19N5O4/c1-25-11-10-21(29,20(25)28)9-8-13-4-3-5-14(12-13)26-19-15(17(24-26)18(22)27)6-7-16(23-19)30-2/h3-7,12,29H,10-11H2,1-2H3,(H2,22,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312839
PNG
(4-(ethylamino)-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CCNc1nccc2n(nc(C(N)=O)c12)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C22H22N6O3/c1-3-24-20-17-16(8-11-25-20)28(26-18(17)19(23)29)15-6-4-5-14(13-15)7-9-22(31)10-12-27(2)21(22)30/h4-6,8,11,13,31H,3,10,12H2,1-2H3,(H2,23,29)(H,24,25)/t22-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312907
PNG
(2-[2-fluoro-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc(F)c(c2)-c2nc(C(N)=O)c(C)s2)C1=O
Show InChI InChI=1S/C18H16FN3O3S/c1-10-14(15(20)23)21-16(26-10)12-9-11(3-4-13(12)19)5-6-18(25)7-8-22(2)17(18)24/h3-4,9,25H,7-8H2,1-2H3,(H2,20,23)/t18-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312804
PNG
(6-chloro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3cc(Cl)ccc23)C1=O
Show InChI InChI=1S/C21H17ClN4O3/c1-25-10-9-21(29,20(25)28)8-7-13-3-2-4-14(11-13)17-16-6-5-15(22)12-26(16)19(24-17)18(23)27/h2-6,11-12,29H,9-10H2,1H3,(H2,23,27)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312812
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)C2N=C(C(N)=O)c3cc(ccc23)-c2ccn(C)n2)C1=O
Show InChI InChI=1S/C26H23N5O3/c1-30-13-11-26(34,25(30)33)10-8-16-4-3-5-18(14-16)22-19-7-6-17(21-9-12-31(2)29-21)15-20(19)23(28-22)24(27)32/h3-7,9,12,14-15,22,34H,11,13H2,1-2H3,(H2,27,32)/t22?,26-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312813
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)-c2ccn(C)n2)C1=O
Show InChI InChI=1S/C25H22N6O3/c1-29-13-11-25(34,24(29)33)10-8-16-4-3-5-18(14-16)31-21-7-6-17(20-9-12-30(2)27-20)15-19(21)22(28-31)23(26)32/h3-7,9,12,14-15,34H,11,13H2,1-2H3,(H2,26,32)/t25-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312823
PNG
(5-[1-(2-hydroxyethyl)pyrazol- 4-yl]-1-[3-[2-[(3R)-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)-c2cnn(CCO)c2)C1=O
Show InChI InChI=1S/C26H24N6O4/c1-30-10-9-26(36,25(30)35)8-7-17-3-2-4-20(13-17)32-22-6-5-18(14-21(22)23(29-32)24(27)34)19-15-28-31(16-19)11-12-33/h2-6,13-16,33,36H,9-12H2,1H3,(H2,27,34)/t26-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312711
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O3/c1-24-12-11-21(28,20(24)27)10-9-14-5-4-6-15(13-14)25-17-8-3-2-7-16(17)18(23-25)19(22)26/h2-8,13,28H,11-12H2,1H3,(H2,22,26)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312765
PNG
(5-fluoro-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C20H16FN5O3/c1-25-9-7-20(29,19(25)28)6-4-12-5-8-23-16(10-12)26-15-3-2-13(21)11-14(15)17(24-26)18(22)27/h2-3,5,8,10-11,29H,7,9H2,1H3,(H2,22,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312822
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CNC(=O)c1ccc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C23H21N5O4/c1-25-21(30)15-6-7-18-17(13-15)19(20(24)29)26-28(18)16-5-3-4-14(12-16)8-9-23(32)10-11-27(2)22(23)31/h3-7,12-13,32H,10-11H2,1-2H3,(H2,24,29)(H,25,30)/t23-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312764
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cccnc23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-11-9-20(28,19(24)27)8-7-13-4-2-5-14(12-13)25-18-15(6-3-10-22-18)16(23-25)17(21)26/h2-6,10,12,28H,9,11H2,1H3,(H2,21,26)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312866
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(nc23)-c2cnn(C)c2)C1=O
Show InChI InChI=1S/C24H21N7O3/c1-29-11-10-24(34,23(29)33)9-8-15-4-3-5-17(12-15)31-22-18(20(28-31)21(25)32)6-7-19(27-22)16-13-26-30(2)14-16/h3-7,12-14,34H,10-11H2,1-2H3,(H2,25,32)/t24-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312763
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-11-9-20(28,19(24)27)8-6-13-7-10-22-16(12-13)25-15-5-3-2-4-14(15)17(23-25)18(21)26/h2-5,7,10,12,28H,9,11H2,1H3,(H2,21,26)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312891
PNG
(1-[3-[(3R)-3-hydroxy-3-(5- methyl-1,3,4-oxadiazol-...)
Show SMILES COc1ccn2c(nc(-c3cccc(c3)C#C[C@@](C)(O)c3nnc(C)o3)c2c1)C(N)=O
Show InChI InChI=1S/C22H19N5O4/c1-13-25-26-21(31-13)22(2,29)9-7-14-5-4-6-15(11-14)18-17-12-16(30-3)8-10-27(17)20(24-18)19(23)28/h4-6,8,10-12,29H,1-3H3,(H2,23,28)/t22-/m1/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312896
PNG
(6-chloro-1-[2-fluoro-5-[2-[(3R)- 3-hydroxy-1-methy...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc(F)c(c2)-c2nc(C(N)=O)n3cc(Cl)ccc23)C1=O
Show InChI InChI=1S/C21H16ClFN4O3/c1-26-9-8-21(30,20(26)29)7-6-12-2-4-15(23)14(10-12)17-16-5-3-13(22)11-27(16)19(25-17)18(24)28/h2-5,10-11,30H,8-9H2,1H3,(H2,24,28)/t21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312774
PNG
(6-fluoro-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3ccc(F)cc23)C1=O
Show InChI InChI=1S/C20H16FN5O3/c1-25-9-7-20(29,19(25)28)6-4-12-5-8-23-16(10-12)26-15-11-13(21)2-3-14(15)17(24-26)18(22)27/h2-3,5,8,10-11,29H,7,9H2,1H3,(H2,22,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312903
PNG
((5S)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES C[C@H]1Cc2c(C1)n(nc2C(N)=O)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H22N4O3/c1-13-10-16-17(11-13)25(23-18(16)19(22)26)15-5-3-4-14(12-15)6-7-21(28)8-9-24(2)20(21)27/h3-5,12-13,28H,8-11H2,1-2H3,(H2,22,26)/t13-,21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312814
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(cnc23)-c2cnn(C)c2)C1=O
Show InChI InChI=1S/C24H21N7O3/c1-29-9-8-24(34,23(29)33)7-6-15-4-3-5-18(10-15)31-22-19(20(28-31)21(25)32)11-16(12-26-22)17-13-27-30(2)14-17/h3-5,10-14,34H,8-9H2,1-2H3,(H2,25,32)/t24-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312888
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C(N)=O)C1=O
Show InChI InChI=1S/C22H19N5O4/c1-26-10-8-22(31,21(26)30)7-5-13-3-2-4-14(11-13)17-16-12-15(18(23)28)6-9-27(16)20(25-17)19(24)29/h2-4,6,9,11-12,31H,8,10H2,1H3,(H2,23,28)(H2,24,29)/t22-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312887
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3CCCCc23)C1=O
Show InChI InChI=1S/C21H22N4O3/c1-24-12-10-21(28,20(24)27)9-8-14-5-4-6-15(13-14)17-16-7-2-3-11-25(16)19(23-17)18(22)26/h4-6,13,28H,2-3,7,10-12H2,1H3,(H2,22,26)/t21-/m0/s1
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0.110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312840
PNG
(4-(cyclopropylamino)-1-[3- [2-[(3R)-3-hydroxy-1-me...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3c(NC4CC4)nccc23)C1=O
Show InChI InChI=1S/C23H22N6O3/c1-28-12-10-23(32,22(28)31)9-7-14-3-2-4-16(13-14)29-17-8-11-25-21(26-15-5-6-15)18(17)19(27-29)20(24)30/h2-4,8,11,13,15,32H,5-6,10,12H2,1H3,(H2,24,30)(H,25,26)/t23-/m0/s1
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0.110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312870
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ncc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2n1)C(N)=O
Show InChI InChI=1S/C20H18N6O4/c1-25-9-8-20(29,18(25)28)7-6-12-4-3-5-13(10-12)26-17-14(15(24-26)16(21)27)11-22-19(23-17)30-2/h3-5,10-11,29H,8-9H2,1-2H3,(H2,21,27)/t20-/m0/s1
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312884
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccnnc23)C1=O
Show InChI InChI=1S/C19H16N6O3/c1-24-10-8-19(28,18(24)27)7-5-12-3-2-4-13(11-12)25-17-14(6-9-21-22-17)15(23-25)16(20)26/h2-4,6,9,11,28H,8,10H2,1H3,(H2,20,26)/t19-/m0/s1
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312783
PNG
(6-fluoro-1-[4-[2-[(7R)-7-hy- droxy-5,6-dihydrocycl...)
Show SMILES NC(=O)c1nn(-c2cc(ccn2)C#C[C@]2(O)CCc3cccnc23)c2cc(F)ccc12
Show InChI InChI=1S/C23H16FN5O2/c24-16-3-4-17-18(13-16)29(28-20(17)22(25)30)19-12-14(7-11-26-19)5-8-23(31)9-6-15-2-1-10-27-21(15)23/h1-4,7,10-13,31H,6,9H2,(H2,25,30)/t23-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312807
PNG
(7-(cyclobutoxy)-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(OC4CCC4)cc23)C1=O
Show InChI InChI=1S/C25H24N4O4/c1-28-13-11-25(32,24(28)31)10-8-16-4-2-5-17(14-16)21-20-15-19(33-18-6-3-7-18)9-12-29(20)23(27-21)22(26)30/h2,4-5,9,12,14-15,18,32H,3,6-7,11,13H2,1H3,(H2,26,30)/t25-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312777
PNG
(5-bromo-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3cc(Br)ccc23)C1=O
Show InChI InChI=1S/C20H16BrN5O3/c1-25-9-7-20(29,19(25)28)6-4-12-5-8-23-16(10-12)26-15-3-2-13(21)11-14(15)17(24-26)18(22)27/h2-3,5,8,10-11,29H,7,9H2,1H3,(H2,22,27)/t20-/m0/s1
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312802
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C(F)(F)F)C1=O
Show InChI InChI=1S/C22H17F3N4O3/c1-28-10-8-21(32,20(28)31)7-5-13-3-2-4-14(11-13)17-16-12-15(22(23,24)25)6-9-29(16)19(27-17)18(26)30/h2-4,6,9,11-12,32H,8,10H2,1H3,(H2,26,30)/t21-/m0/s1
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312824
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cncnc23)C1=O
Show InChI InChI=1S/C19H16N6O3/c1-24-8-7-19(28,18(24)27)6-5-12-3-2-4-13(9-12)25-17-14(10-21-11-22-17)15(23-25)16(20)26/h2-4,9-11,28H,7-8H2,1H3,(H2,20,26)/t19-/m0/s1
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312893
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COC1CN(C1)c1cnc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-28-9-8-24(33,23(28)32)7-6-15-4-3-5-16(10-15)30-22-19(20(27-30)21(25)31)11-17(12-26-22)29-13-18(14-29)34-2/h3-5,10-12,18,33H,8-9,13-14H2,1-2H3,(H2,25,31)/t24-/m0/s1
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312848
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(cc23)N2CC[C@@H](O)C2)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-28-10-8-24(34,23(28)33)7-5-15-3-2-4-16(11-15)30-19-12-20(29-9-6-17(31)14-29)26-13-18(19)21(27-30)22(25)32/h2-4,11-13,17,31,34H,6,8-10,14H2,1H3,(H2,25,32)/t17-,24+/m1/s1
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312875
PNG
(US9605005, Example 165 | ethyl 3-carbamoyl-1-[4-[2...)
Show SMILES CCOC(=O)N1CCc2c(C1)c(nn2-c1cc(ccn1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O
Show InChI InChI=1S/C22H24N6O5/c1-3-33-21(31)27-10-6-16-15(13-27)18(19(23)29)25-28(16)17-12-14(5-9-24-17)4-7-22(32)8-11-26(2)20(22)30/h5,9,12,32H,3,6,8,10-11,13H2,1-2H3,(H2,23,29)/t22-/m0/s1
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0.230n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312868
PNG
(6-cyclopropyl-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(nc23)C2CC2)C1=O
Show InChI InChI=1S/C22H20N6O3/c1-27-10-9-22(31,21(27)30)8-7-13-3-2-4-15(11-13)28-20-16(17(26-28)18(23)29)12-24-19(25-20)14-5-6-14/h2-4,11-12,14,31H,5-6,9-10H2,1H3,(H2,23,29)/t22-/m0/s1
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0.230n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312818
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3[nH]c(=O)ccc23)C1=O
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0.240n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312786
PNG
(5-fluoro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(F)cnc23)C1=O
Show InChI InChI=1S/C20H16FN5O3/c1-25-8-7-20(29,19(25)28)6-5-12-3-2-4-14(9-12)26-18-15(10-13(21)11-23-18)16(24-26)17(22)27/h2-4,9-11,29H,7-8H2,1H3,(H2,22,27)/t20-/m0/s1
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0.240n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312847
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(cc23)N2CCCC2)C1=O
Show InChI InChI=1S/C24H24N6O3/c1-28-12-9-24(33,23(28)32)8-7-16-5-4-6-17(13-16)30-19-14-20(29-10-2-3-11-29)26-15-18(19)21(27-30)22(25)31/h4-6,13-15,33H,2-3,9-12H2,1H3,(H2,25,31)/t24-/m0/s1
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0.25n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312909
PNG
(5,5-difluoro-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2-o...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CC(F)(F)Cc23)C1=O
Show InChI InChI=1S/C20H18F2N4O3/c1-25-8-7-19(29,18(25)28)6-5-12-3-2-4-13(9-12)26-15-11-20(21,22)10-14(15)16(24-26)17(23)27/h2-4,9,29H,7-8,10-11H2,1H3,(H2,23,27)/t19-/m0/s1
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0.260n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312865
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(nc23)N2CCOCC2)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-28-10-9-24(33,23(28)32)8-7-16-3-2-4-17(15-16)30-22-18(20(27-30)21(25)31)5-6-19(26-22)29-11-13-34-14-12-29/h2-6,15,33H,9-14H2,1H3,(H2,25,31)/t24-/m0/s1
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0.260n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312723
PNG
(5-fluoro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(F)ccc23)C1=O
Show InChI InChI=1S/C21H17FN4O3/c1-25-10-9-21(29,20(25)28)8-7-13-3-2-4-15(11-13)26-17-6-5-14(22)12-16(17)18(24-26)19(23)27/h2-6,11-12,29H,9-10H2,1H3,(H2,23,27)/t21-/m0/s1
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0.270n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312860
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2cn1)C(N)=O
Show InChI InChI=1S/C21H19N5O4/c1-25-9-8-21(29,20(25)28)7-6-13-4-3-5-14(10-13)26-16-12-23-17(30-2)11-15(16)18(24-26)19(22)27/h3-5,10-12,29H,8-9H2,1-2H3,(H2,22,27)/t21-/m0/s1
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0.290n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312832
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)c2nccs2)C1=O
Show InChI InChI=1S/C23H22N6O3S/c1-27-11-8-23(32,21(27)31)7-5-15-3-2-4-16(13-15)29-18-6-10-28(22-25-9-12-33-22)14-17(18)19(26-29)20(24)30/h2-4,9,12-13,32H,6,8,10-11,14H2,1H3,(H2,24,30)/t23-/m0/s1
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0.290n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312908
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CCCNc23)C1=O
Show InChI InChI=1S/C20H21N5O3/c1-24-11-9-20(28,19(24)27)8-7-13-4-2-5-14(12-13)25-18-15(6-3-10-22-18)16(23-25)17(21)26/h2,4-5,12,22,28H,3,6,9-11H2,1H3,(H2,21,26)/t20-/m0/s1
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0.290n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312854
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3scnc23)C1=O
Show InChI InChI=1S/C18H15N5O3S/c1-22-8-7-18(26,17(22)25)6-5-11-3-2-4-12(9-11)23-16-14(27-10-20-16)13(21-23)15(19)24/h2-4,9-10,26H,7-8H2,1H3,(H2,19,24)/t18-/m0/s1
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0.310n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312841
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(C)cc23)C1=O
Show InChI InChI=1S/C21H19N5O3/c1-13-10-17-16(12-23-13)18(19(22)27)24-26(17)15-5-3-4-14(11-15)6-7-21(29)8-9-25(2)20(21)28/h3-5,10-12,29H,8-9H2,1-2H3,(H2,22,27)/t21-/m0/s1
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0.310n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312827
PNG
(1-[3-[(3R)-3-hydroxy-3-(1H- triazol-4-yl)but-1-yny...)
Show SMILES C[C@@](O)(C#Cc1cccc(c1)-n1nc(C(N)=O)c2ccccc12)c1c[nH]nn1
Show InChI InChI=1S/C20H16N6O2/c1-20(28,17-12-22-25-23-17)10-9-13-5-4-6-14(11-13)26-16-8-3-2-7-15(16)18(24-26)19(21)27/h2-8,11-12,28H,1H3,(H2,21,27)(H,22,23,25)/t20-/m1/s1
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0.320n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312752
PNG
(5-(cyanomethyl)-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(CC#N)ccc23)C1=O
Show InChI InChI=1S/C23H19N5O3/c1-27-12-10-23(31,22(27)30)9-7-15-3-2-4-17(13-15)28-19-6-5-16(8-11-24)14-18(19)20(26-28)21(25)29/h2-6,13-14,31H,8,10,12H2,1H3,(H2,25,29)/t23-/m0/s1
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0.320n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312857
PNG
(3-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nn(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O3/c1-24-12-11-21(28,19(24)26)10-9-14-5-4-6-15(13-14)18-16-7-2-3-8-17(16)25(23-18)20(22)27/h2-8,13,28H,11-12H2,1H3,(H2,22,27)/t21-/m0/s1
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0.324n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312732
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2c1)C(N)=O
Show InChI InChI=1S/C22H20N4O4/c1-25-11-10-22(29,21(25)28)9-8-14-4-3-5-15(12-14)26-18-13-16(30-2)6-7-17(18)19(24-26)20(23)27/h3-7,12-13,29H,10-11H2,1-2H3,(H2,23,27)/t22-/m0/s1
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0.340n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312890
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3NC(=O)CCc23)C1=O
Show InChI InChI=1S/C20H19N5O4/c1-24-10-9-20(29,19(24)28)8-7-12-3-2-4-13(11-12)25-14-5-6-15(26)22-16(14)17(23-25)18(21)27/h2-4,11,29H,5-6,9-10H2,1H3,(H2,21,27)(H,22,26)/t20-/m0/s1
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0.350n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312872
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(OCCN4CCOCC4)ccc23)C1=O
Show InChI InChI=1S/C27H29N5O5/c1-30-10-9-27(35,26(30)34)8-7-19-3-2-4-20(17-19)32-23-6-5-21(18-22(23)24(29-32)25(28)33)37-16-13-31-11-14-36-15-12-31/h2-6,17-18,35H,9-16H2,1H3,(H2,28,33)/t27-/m0/s1
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0.350n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312803
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccncc23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-9-7-20(28,19(24)27)6-5-13-3-2-4-14(11-13)16-15-12-22-8-10-25(15)18(23-16)17(21)26/h2-4,8,10-12,28H,7,9H2,1H3,(H2,21,26)/t20-/m0/s1
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0.370n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312842
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnccc23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-10-8-20(28,19(24)27)7-5-13-3-2-4-14(11-13)25-16-6-9-22-12-15(16)17(23-25)18(21)26/h2-4,6,9,11-12,28H,8,10H2,1H3,(H2,21,26)/t20-/m0/s1
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0.378n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312858
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccncc23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-10-8-20(28,19(24)27)7-5-13-3-2-4-14(11-13)25-16-12-22-9-6-15(16)17(23-25)18(21)26/h2-4,6,9,11-12,28H,8,10H2,1H3,(H2,21,26)/t20-/m0/s1
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0.380n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312846
PNG
(6-ethoxy-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CCOc1cc2n(nc(C(N)=O)c2cn1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C22H21N5O4/c1-3-31-18-12-17-16(13-24-18)19(20(23)28)25-27(17)15-6-4-5-14(11-15)7-8-22(30)9-10-26(2)21(22)29/h4-6,11-13,30H,3,9-10H2,1-2H3,(H2,23,28)/t22-/m0/s1
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0.390n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312849
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(cc23)N2CC[C@H](O)C2)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-28-10-8-24(34,23(28)33)7-5-15-3-2-4-16(11-15)30-19-12-20(29-9-6-17(31)14-29)26-13-18(19)21(27-30)22(25)32/h2-4,11-13,17,31,34H,6,8-10,14H2,1H3,(H2,25,32)/t17-,24-/m0/s1
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0.390n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312736
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3sc(C)nc23)C1=O
Show InChI InChI=1S/C19H17N5O3S/c1-11-21-17-15(28-11)14(16(20)25)22-24(17)13-5-3-4-12(10-13)6-7-19(27)8-9-23(2)18(19)26/h3-5,10,27H,8-9H2,1-2H3,(H2,20,25)/t19-/m0/s1
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0.410n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312829
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CCCc23)C1=O
Show InChI InChI=1S/C20H20N4O3/c1-23-11-10-20(27,19(23)26)9-8-13-4-2-5-14(12-13)24-16-7-3-6-15(16)17(22-24)18(21)25/h2,4-5,12,27H,3,6-7,10-11H2,1H3,(H2,21,25)/t20-/m0/s1
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0.430n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312755
PNG
(1-[3-chloro-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(Cl)cc(c2)-n2nc(C(N)=O)c3cccnc23)C1=O
Show InChI InChI=1S/C20H16ClN5O3/c1-25-8-6-20(29,19(25)28)5-4-12-9-13(21)11-14(10-12)26-18-15(3-2-7-23-18)16(24-26)17(22)27/h2-3,7,9-11,29H,6,8H2,1H3,(H2,22,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312757
PNG
(6-cyano-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(cc23)C#N)C1=O
Show InChI InChI=1S/C22H17N5O3/c1-26-10-9-22(30,21(26)29)8-7-14-3-2-4-16(11-14)27-18-12-15(13-23)5-6-17(18)19(25-27)20(24)28/h2-6,11-12,30H,9-10H2,1H3,(H2,24,28)/t22-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312830
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)c2ccncn2)C1=O
Show InChI InChI=1S/C24H23N7O3/c1-29-12-9-24(34,23(29)33)8-5-16-3-2-4-17(13-16)31-19-7-11-30(20-6-10-26-15-27-20)14-18(19)21(28-31)22(25)32/h2-4,6,10,13,15,34H,7,9,11-12,14H2,1H3,(H2,25,32)/t24-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312863
PNG
(6-chloro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(Cl)nc23)C1=O
Show InChI InChI=1S/C20H16ClN5O3/c1-25-10-9-20(29,19(25)28)8-7-12-3-2-4-13(11-12)26-18-14(5-6-15(21)23-18)16(24-26)17(22)27/h2-6,11,29H,9-10H2,1H3,(H2,22,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312883
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2nn1)C(N)=O
Show InChI InChI=1S/C20H18N6O4/c1-25-9-8-20(29,19(25)28)7-6-12-4-3-5-13(10-12)26-18-14(16(24-26)17(21)27)11-15(30-2)22-23-18/h3-5,10-11,29H,8-9H2,1-2H3,(H2,21,27)/t20-/m0/s1
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0.550n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312820
PNG
((4S)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES C[C@H]1CCc2c1c(nn2-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O
Show InChI InChI=1S/C21H22N4O3/c1-13-6-7-16-17(13)18(19(22)26)23-25(16)15-5-3-4-14(12-15)8-9-21(28)10-11-24(2)20(21)27/h3-5,12-13,28H,6-7,10-11H2,1-2H3,(H2,22,26)/t13-,21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312742
PNG
(1-[4-fluoro-3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(ccc2F)-n2nc(C(N)=O)c3cccnc23)C1=O
Show InChI InChI=1S/C20H16FN5O3/c1-25-10-8-20(29,19(25)28)7-6-12-11-13(4-5-15(12)21)26-18-14(3-2-9-23-18)16(24-26)17(22)27/h2-5,9,11,29H,8,10H2,1H3,(H2,22,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312826
PNG
(1-[3-[2-[(1R)-1-hydroxy-2- oxo-cyclopentyl]ethynyl...)
Show SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@]2(O)CCCC2=O)c2ccccc12
Show InChI InChI=1S/C21H17N3O3/c22-20(26)19-16-7-1-2-8-17(16)24(23-19)15-6-3-5-14(13-15)10-12-21(27)11-4-9-18(21)25/h1-3,5-8,13,27H,4,9,11H2,(H2,22,26)/t21-/m1/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312815
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(cnc23)N2CCOCC2)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-28-8-7-24(33,23(28)32)6-5-16-3-2-4-17(13-16)30-22-19(20(27-30)21(25)31)14-18(15-26-22)29-9-11-34-12-10-29/h2-4,13-15,33H,7-12H2,1H3,(H2,25,31)/t24-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312782
PNG
(6-fluoro-1-[4-[2-[(3R)-3-hy- droxy-2-oxo-pyrrolidi...)
Show SMILES NC(=O)c1nn(-c2cc(ccn2)C#C[C@]2(O)CCNC2=O)c2cc(F)ccc12
Show InChI InChI=1S/C19H14FN5O3/c20-12-1-2-13-14(10-12)25(24-16(13)17(21)26)15-9-11(4-7-22-15)3-5-19(28)6-8-23-18(19)27/h1-2,4,7,9-10,28H,6,8H2,(H2,21,26)(H,23,27)/t19-/m0/s1
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0.640n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312753
PNG
(5-cyano-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)C#N)C1=O
Show InChI InChI=1S/C22H17N5O3/c1-26-10-9-22(30,21(26)29)8-7-14-3-2-4-16(11-14)27-18-6-5-15(13-23)12-17(18)19(25-27)20(24)28/h2-6,11-12,30H,9-10H2,1H3,(H2,24,28)/t22-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312867
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(C)nc23)C1=O
Show InChI InChI=1S/C20H18N6O3/c1-12-22-11-15-16(17(21)27)24-26(18(15)23-12)14-5-3-4-13(10-14)6-7-20(29)8-9-25(2)19(20)28/h3-5,10-11,29H,8-9H2,1-2H3,(H2,21,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312845
PNG
(6-cyano-1-[3-[2-[(7S)-7-hy- droxy-5,6-dihydrocyclo...)
Show SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@@]2(O)CCc3cccnc23)c2cc(ncc12)C#N
Show InChI InChI=1S/C24H16N6O2/c25-13-17-12-20-19(14-28-17)21(23(26)31)29-30(20)18-5-1-3-15(11-18)6-8-24(32)9-7-16-4-2-10-27-22(16)24/h1-5,10-12,14,32H,7,9H2,(H2,26,31)/t24-/m1/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312797
PNG
(7-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c3cccnn23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-11-9-20(28,19(24)27)8-7-13-4-2-5-14(12-13)18-23-16(17(21)26)15-6-3-10-22-25(15)18/h2-6,10,12,28H,9,11H2,1H3,(H2,21,26)/t20-/m0/s1
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0.730n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312880
PNG
(1-[3-[(3R)-3-hydroxy-3-thia- zol-2-yl-but-1-ynyl]p...)
Show SMILES CC(C)(C#Cc1cccc(c1)-n1nc(C(N)=O)c2ccccc12)c1nccs1
Show InChI InChI=1S/C22H18N4OS/c1-22(2,21-24-12-13-28-21)11-10-15-6-5-7-16(14-15)26-18-9-4-3-8-17(18)19(25-26)20(23)27/h3-9,12-14H,1-2H3,(H2,23,27)
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0.75n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312781
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3COCCc23)C1=O
Show InChI InChI=1S/C20H20N4O4/c1-23-9-8-20(27,19(23)26)7-5-13-3-2-4-14(11-13)24-16-6-10-28-12-15(16)17(22-24)18(21)25/h2-4,11,27H,6,8-10,12H2,1H3,(H2,21,25)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312762
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3CCCCc23)C1=O
Show InChI InChI=1S/C20H21N5O3/c1-24-11-9-20(28,19(24)27)8-6-13-7-10-22-16(12-13)25-15-5-3-2-4-14(15)17(23-25)18(21)26/h7,10,12,28H,2-5,9,11H2,1H3,(H2,21,26)/t20-/m0/s1
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0.808n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312898
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CC1Cc2c(C1)n(nc2C(N)=O)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H22N4O3/c1-13-10-16-17(11-13)25(23-18(16)19(22)26)15-5-3-4-14(12-15)6-7-21(28)8-9-24(2)20(21)27/h3-5,12-13,28H,8-11H2,1-2H3,(H2,22,26)/t13?,21-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312728
PNG
(1-[3-fluoro-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(F)cc(c2)-n2nc(C(N)=O)c3cccnc23)C1=O
Show InChI InChI=1S/C20H16FN5O3/c1-25-8-6-20(29,19(25)28)5-4-12-9-13(21)11-14(10-12)26-18-15(3-2-7-23-18)16(24-26)17(22)27/h2-3,7,9-11,29H,6,8H2,1H3,(H2,22,27)/t20-/m0/s1
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Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312862
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(C)cc(c2)-n2nc(C(N)=O)c3cccnc23)C1=O
Show InChI InChI=1S/C21H19N5O3/c1-13-10-14(5-6-21(29)7-9-25(2)20(21)28)12-15(11-13)26-19-16(4-3-8-23-19)17(24-26)18(22)27/h3-4,8,10-12,29H,7,9H2,1-2H3,(H2,22,27)/t21-/m0/s1
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0.870n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312767
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3CCCc23)C1=O
Show InChI InChI=1S/C19H19N5O3/c1-23-10-8-19(27,18(23)26)7-5-12-6-9-21-15(11-12)24-14-4-2-3-13(14)16(22-24)17(20)25/h6,9,11,27H,2-4,8,10H2,1H3,(H2,20,25)/t19-/m0/s1
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0.870n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312726
PNG
(US9605005, Example 16 | tert-butyl 3-carbamoyl-1-[...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C25H29N5O5/c1-24(2,3)35-23(33)29-12-9-19-18(15-29)20(21(26)31)27-30(19)17-7-5-6-16(14-17)8-10-25(34)11-13-28(4)22(25)32/h5-7,14,34H,9,11-13,15H2,1-4H3,(H2,26,31)/t25-/m0/s1
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0.900n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312784
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cc(cc(c1)-n1nc(C(N)=O)c2cccnc12)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C21H19N5O4/c1-25-9-7-21(29,20(25)28)6-5-13-10-14(12-15(11-13)30-2)26-19-16(4-3-8-23-19)17(24-26)18(22)27/h3-4,8,10-12,29H,7,9H2,1-2H3,(H2,22,27)/t21-/m0/s1
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1.05n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312831
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)c2ncccn2)C1=O
Show InChI InChI=1S/C24H23N7O3/c1-29-13-9-24(34,22(29)33)8-6-16-4-2-5-17(14-16)31-19-7-12-30(23-26-10-3-11-27-23)15-18(19)20(28-31)21(25)32/h2-5,10-11,14,34H,7,9,12-13,15H2,1H3,(H2,25,32)/t24-/m0/s1
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1.05n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312712
PNG
((4R)-4-hydroxy-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3[C@H](O)CCCc23)C1=O
Show InChI InChI=1S/C21H22N4O4/c1-24-11-10-21(29,20(24)28)9-8-13-4-2-5-14(12-13)25-15-6-3-7-16(26)17(15)18(23-25)19(22)27/h2,4-5,12,16,26,29H,3,6-7,10-11H2,1H3,(H2,22,27)/t16-,21+/m1/s1
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1.07n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312859
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(C)ncc23)C1=O
Show InChI InChI=1S/C21H19N5O3/c1-13-10-16-17(12-23-13)26(24-18(16)19(22)27)15-5-3-4-14(11-15)6-7-21(29)8-9-25(2)20(21)28/h3-5,10-12,29H,8-9H2,1-2H3,(H2,22,27)/t21-/m0/s1
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1.08n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312901
PNG
(1-[2-fluoro-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc(F)c(c2)-n2nc(C(N)=O)c3COCc23)C1=O
Show InChI InChI=1S/C19H17FN4O4/c1-23-7-6-19(27,18(23)26)5-4-11-2-3-13(20)14(8-11)24-15-10-28-9-12(15)16(22-24)17(21)25/h2-3,8,27H,6-7,9-10H2,1H3,(H2,21,25)/t19-/m0/s1
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1.11n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312897
PNG
(7-chloro-1-[3-[(3R)-3-hydroxy- 3-(5-methyl-1,3,4-o...)
Show SMILES Cc1nnc(o1)C(C)(C)C#Cc1cccc(c1)-c1nc(C(N)=O)n2ccc(Cl)cc12
Show InChI InChI=1S/C22H18ClN5O2/c1-13-26-27-21(30-13)22(2,3)9-7-14-5-4-6-15(11-14)18-17-12-16(23)8-10-28(17)20(25-18)19(24)29/h4-6,8,10-12H,1-3H3,(H2,24,29)
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1.12n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312713
PNG
((4S)-4-hydroxy-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3[C@@H](O)CCCc23)C1=O
Show InChI InChI=1S/C21H22N4O4/c1-24-11-10-21(29,20(24)28)9-8-13-4-2-5-14(12-13)25-15-6-3-7-16(26)17(15)18(23-25)19(22)27/h2,4-5,12,16,26,29H,3,6-7,10-11H2,1H3,(H2,22,27)/t16-,21-/m0/s1
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1.13n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312720
PNG
(4-fluoro-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3c(F)cccc23)C1=O
Show InChI InChI=1S/C20H16FN5O3/c1-25-10-8-20(29,19(25)28)7-5-12-6-9-23-15(11-12)26-14-4-2-3-13(21)16(14)17(24-26)18(22)27/h2-4,6,9,11,29H,8,10H2,1H3,(H2,22,27)/t20-/m0/s1
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1.19n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312876
PNG
(1-[2-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(ccn2)-n2nc(C(N)=O)c3CCCCc23)C1=O
Show InChI InChI=1S/C20H21N5O3/c1-24-11-9-20(28,19(24)27)8-6-13-12-14(7-10-22-13)25-16-5-3-2-4-15(16)17(23-25)18(21)26/h7,10,12,28H,2-5,9,11H2,1H3,(H2,21,26)/t20-/m0/s1
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1.19n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312750
PNG
(4-chloro-1-[3-[2-[(3R)-3- hydroxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3c(Cl)cccc23)C1=O
Show InChI InChI=1S/C21H17ClN4O3/c1-25-11-10-21(29,20(25)28)9-8-13-4-2-5-14(12-13)26-16-7-3-6-15(22)17(16)18(24-26)19(23)27/h2-7,12,29H,10-11H2,1H3,(H2,23,27)/t21-/m0/s1
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1.21n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312855
PNG
(1-[2-fluoro-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc(F)c(c2)-n2nc(C(N)=O)c3CCCc23)C1=O
Show InChI InChI=1S/C20H19FN4O3/c1-24-10-9-20(28,19(24)27)8-7-12-5-6-14(21)16(11-12)25-15-4-2-3-13(15)17(23-25)18(22)26/h5-6,11,28H,2-4,9-10H2,1H3,(H2,22,26)/t20-/m0/s1
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1.24n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312886
PNG
(7-fluoro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cccc(F)c23)C1=O
Show InChI InChI=1S/C21H17FN4O3/c1-25-11-10-21(29,20(25)28)9-8-13-4-2-5-14(12-13)26-18-15(6-3-7-16(18)22)17(24-26)19(23)27/h2-7,12,29H,10-11H2,1H3,(H2,23,27)/t21-/m0/s1
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1.27n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312843
PNG
(6-cyano-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(cc23)C#N)C1=O
Show InChI InChI=1S/C21H16N6O3/c1-26-8-7-21(30,20(26)29)6-5-13-3-2-4-15(9-13)27-17-10-14(11-22)24-12-16(17)18(25-27)19(23)28/h2-4,9-10,12,30H,7-8H2,1H3,(H2,23,28)/t21-/m0/s1
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1.31n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312768
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CCCCc23)C1=O
Show InChI InChI=1S/C21H22N4O3/c1-24-12-11-21(28,20(24)27)10-9-14-5-4-6-15(13-14)25-17-8-3-2-7-16(17)18(23-25)19(22)26/h4-6,13,28H,2-3,7-8,11-12H2,1H3,(H2,22,26)/t21-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312746
PNG
(5-(hydroxymethyl)-1-[3-[2- [(3R)-3-hydroxy-1-methy...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(CO)ccc23)C1=O
Show InChI InChI=1S/C22H20N4O4/c1-25-10-9-22(30,21(25)29)8-7-14-3-2-4-16(11-14)26-18-6-5-15(13-27)12-17(18)19(24-26)20(23)28/h2-6,11-12,27,30H,9-10,13H2,1H3,(H2,23,28)/t22-/m0/s1
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1.48n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312892
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)-c2ncc[nH]2)C1=O
Show InChI InChI=1S/C24H20N6O3/c1-29-12-9-24(33,23(29)32)8-7-15-3-2-4-17(13-15)30-19-6-5-16(22-26-10-11-27-22)14-18(19)20(28-30)21(25)31/h2-6,10-11,13-14,33H,9,12H2,1H3,(H2,25,31)(H,26,27)/t24-/m0/s1
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1.51n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312810
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(CN4CCOCC4)cc23)C1=O
Show InChI InChI=1S/C26H27N5O4/c1-29-10-8-26(34,25(29)33)7-5-18-3-2-4-20(15-18)22-21-16-19(17-30-11-13-35-14-12-30)6-9-31(21)24(28-22)23(27)32/h2-4,6,9,15-16,34H,8,10-14,17H2,1H3,(H2,27,32)/t26-/m0/s1
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1.52n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312853
PNG
(1-[3-[2-[(3S)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CNC(=O)c23)C1=O
Show InChI InChI=1S/C19H17N5O4/c1-23-8-7-19(28,18(23)27)6-5-11-3-2-4-12(9-11)24-15-13(10-21-17(15)26)14(22-24)16(20)25/h2-4,9,28H,7-8,10H2,1H3,(H2,20,25)(H,21,26)/t19-/m1/s1
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1.54n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312874
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ncccc23)C1=O
Show InChI InChI=1S/C20H17N5O3/c1-24-11-9-20(28,19(24)27)8-7-13-4-2-5-14(12-13)25-15-6-3-10-22-16(15)17(23-25)18(21)26/h2-6,10,12,28H,9,11H2,1H3,(H2,21,26)/t20-/m0/s1
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1.54n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312722
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CCCOc23)C1=O
Show InChI InChI=1S/C20H20N4O4/c1-23-10-9-20(27,19(23)26)8-7-13-4-2-5-14(12-13)24-18-15(6-3-11-28-18)16(22-24)17(21)25/h2,4-5,12,27H,3,6,9-11H2,1H3,(H2,21,25)/t20-/m0/s1
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1.56n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312754
PNG
(5-[(1R)-1-hydroxyethyl]-1- [3-[2-[(3R)-3-hydroxy-1...)
Show SMILES C[C@@H](O)c1ccc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C23H22N4O4/c1-14(28)16-6-7-19-18(13-16)20(21(24)29)25-27(19)17-5-3-4-15(12-17)8-9-23(31)10-11-26(2)22(23)30/h3-7,12-14,28,31H,10-11H2,1-2H3,(H2,24,29)/t14-,23+/m1/s1
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1.60n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312800
PNG
(4-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2csc(n2)C(N)=O)C1=O
Show InChI InChI=1S/C17H15N3O3S/c1-20-8-7-17(23,16(20)22)6-5-11-3-2-4-12(9-11)13-10-24-15(19-13)14(18)21/h2-4,9-10,23H,7-8H2,1H3,(H2,18,21)/t17-/m0/s1
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1.65n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312811
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3cc(CN4CCOCC4)ccc23)C1=O
Show InChI InChI=1S/C26H27N5O4/c1-29-10-9-26(34,25(29)33)8-7-18-3-2-4-20(15-18)22-21-6-5-19(16-30-11-13-35-14-12-30)17-31(21)24(28-22)23(27)32/h2-6,15,17,34H,9-14,16H2,1H3,(H2,27,32)/t26-/m0/s1
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1.65n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312852
PNG
(5-[[butanoyl(methyl)amino] methyl]-1-[4-[2-[(3R)-3...)
Show SMILES CCCC(=O)N(C)Cc1ccc2n(nc(C(N)=O)c2c1)-c1cc(ccn1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C26H28N6O4/c1-4-5-22(33)31(3)16-18-6-7-20-19(14-18)23(24(27)34)29-32(20)21-15-17(9-12-28-21)8-10-26(36)11-13-30(2)25(26)35/h6-7,9,12,14-15,36H,4-5,11,13,16H2,1-3H3,(H2,27,34)/t26-/m0/s1
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1.71n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312856
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3COCc23)C1=O
Show InChI InChI=1S/C19H18N4O4/c1-22-8-7-19(26,18(22)25)6-5-12-3-2-4-13(9-12)23-15-11-27-10-14(15)16(21-23)17(20)24/h2-4,9,26H,7-8,10-11H2,1H3,(H2,20,24)/t19-/m0/s1
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1.77n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312817
PNG
(5-(1-acetylazetidin-3-yl)-1- [3-[2-[(3R)-3-hydroxy...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(cnc23)C2CN(C2)C(C)=O)C1=O
Show InChI InChI=1S/C25H24N6O4/c1-15(32)30-13-18(14-30)17-11-20-21(22(26)33)28-31(23(20)27-12-17)19-5-3-4-16(10-19)6-7-25(35)8-9-29(2)24(25)34/h3-5,10-12,18,35H,8-9,13-14H2,1-2H3,(H2,26,33)/t25-/m0/s1
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1.82n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312877
PNG
(1-[4-cyano-3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(ccc2C#N)-n2nc(C(N)=O)c3CCCCc23)C1=O
Show InChI InChI=1S/C22H21N5O3/c1-26-11-10-22(30,21(26)29)9-8-14-12-16(7-6-15(14)13-23)27-18-5-3-2-4-17(18)19(25-27)20(24)28/h6-7,12,30H,2-5,10-11H2,1H3,(H2,24,28)/t22-/m0/s1
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1.93n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312756
PNG
(5-[(1S)-1-hydroxyethyl]-1- [3-[2-[(3R)-3-hydroxy-1...)
Show SMILES C[C@H](O)c1ccc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C23H22N4O4/c1-14(28)16-6-7-19-18(13-16)20(21(24)29)25-27(19)17-5-3-4-15(12-17)8-9-23(31)10-11-26(2)22(23)30/h3-7,12-14,28,31H,10-11H2,1-2H3,(H2,24,29)/t14-,23-/m0/s1
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2.33n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312737
PNG
(1-[3-[(3R)-3-hydroxy-3-(5- methyl-1,3,4-oxadiazol-...)
Show SMILES Cc1nnc(o1)[C@](C)(O)C#Cc1cccc(c1)-n1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C21H17N5O3/c1-13-23-24-20(29-13)21(2,28)11-10-14-6-5-7-15(12-14)26-17-9-4-3-8-16(17)18(25-26)19(22)27/h3-9,12,28H,1-2H3,(H2,22,27)/t21-/m1/s1
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2.52n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312871
PNG
(5-[2-(azetidin-1-yl)ethoxy]- 1-[3-[2-[(3R)-3-hydro...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(OCCN4CCC4)ccc23)C1=O
Show InChI InChI=1S/C26H27N5O4/c1-29-13-10-26(34,25(29)33)9-8-18-4-2-5-19(16-18)31-22-7-6-20(35-15-14-30-11-3-12-30)17-21(22)23(28-31)24(27)32/h2,4-7,16-17,34H,3,10-15H2,1H3,(H2,27,32)/t26-/m0/s1
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2.52n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312714
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3CCC(C)(C)Cc23)C1=O
Show InChI InChI=1S/C22H25N5O3/c1-21(2)7-5-15-16(13-21)27(25-18(15)19(23)28)17-12-14(6-10-24-17)4-8-22(30)9-11-26(3)20(22)29/h6,10,12,30H,5,7,9,11,13H2,1-3H3,(H2,23,28)/t22-/m0/s1
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2.92n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312879
PNG
((6R)-6-hydroxy-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CC[C@@H](O)c23)C1=O
Show InChI InChI=1S/C20H20N4O4/c1-23-10-9-20(28,19(23)27)8-7-12-3-2-4-13(11-12)24-17-14(5-6-15(17)25)16(22-24)18(21)26/h2-4,11,15,25,28H,5-6,9-10H2,1H3,(H2,21,26)/t15-,20+/m1/s1
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2.96n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312775
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3CC(C)(C)CCc23)C1=O
Show InChI InChI=1S/C22H25N5O3/c1-21(2)7-5-16-15(13-21)18(19(23)28)25-27(16)17-12-14(6-10-24-17)4-8-22(30)9-11-26(3)20(22)29/h6,10,12,30H,5,7,9,11,13H2,1-3H3,(H2,23,28)/t22-/m0/s1
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3.06n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312778
PNG
(1-[3-[(3R)-3-hydroxy-3-(5- methyl-1,3,4-oxadiazol-...)
Show SMILES Cc1nnc(o1)[C@](C)(O)C#Cc1cccc(c1)-n1nc(C(N)=O)c2cccnc12
Show InChI InChI=1S/C20H16N6O3/c1-12-23-24-19(29-12)20(2,28)9-8-13-5-3-6-14(11-13)26-18-15(7-4-10-22-18)16(25-26)17(21)27/h3-7,10-11,28H,1-2H3,(H2,21,27)/t20-/m1/s1
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3.14n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312851
PNG
(5-[[4-aminobutanoyl(meth- yl)amino]methyl]-1-[4-[2...)
Show SMILES CN(Cc1ccc2n(nc(C(N)=O)c2c1)-c1cc(ccn1)C#C[C@]1(O)CCN(C)C1=O)C(=O)CCCN
Show InChI InChI=1S/C26H29N7O4/c1-31-13-10-26(37,25(31)36)9-7-17-8-12-29-21(15-17)33-20-6-5-18(14-19(20)23(30-33)24(28)35)16-32(2)22(34)4-3-11-27/h5-6,8,12,14-15,37H,3-4,10-11,13,16,27H2,1-2H3,(H2,28,35)/t26-/m0/s1
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3.27n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312738
PNG
(6-fluoro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CCC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(F)cc23)C1=O
Show InChI InChI=1S/C22H19FN4O3/c1-26-11-3-9-22(30,21(26)29)10-8-14-4-2-5-16(12-14)27-18-13-15(23)6-7-17(18)19(25-27)20(24)28/h2,4-7,12-13,30H,3,9,11H2,1H3,(H2,24,28)/t22-/m1/s1
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US Patent
3.75n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312861
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3NCCCc23)C1=O
Show InChI InChI=1S/C20H21N5O3/c1-24-11-9-20(28,19(24)27)8-7-13-4-2-5-14(12-13)25-15-6-3-10-22-16(15)17(23-25)18(21)26/h2,4-5,12,22,28H,3,6,9-11H2,1H3,(H2,21,26)/t20-/m0/s1
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3.96n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312780
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CCOCc23)C1=O
Show InChI InChI=1S/C20H20N4O4/c1-23-9-8-20(27,19(23)26)7-5-13-3-2-4-14(11-13)24-16-12-28-10-6-15(16)17(22-24)18(21)25/h2-4,11,27H,6,8-10,12H2,1H3,(H2,21,25)/t20-/m0/s1
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US Patent
3.98n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312772
PNG
((6R)-6-hydroxy-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3CC[C@@H](O)Cc23)C1=O
Show InChI InChI=1S/C20H21N5O4/c1-24-9-7-20(29,19(24)28)6-4-12-5-8-22-16(10-12)25-15-11-13(26)2-3-14(15)17(23-25)18(21)27/h5,8,10,13,26,29H,2-3,7,9,11H2,1H3,(H2,21,27)/t13-,20+/m1/s1
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4.46n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312799
PNG
(3-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c3ccccn23)C1=O
Show InChI InChI=1S/C21H18N4O3/c1-24-12-10-21(28,20(24)27)9-8-14-5-4-6-15(13-14)19-23-17(18(22)26)16-7-2-3-11-25(16)19/h2-7,11,13,28H,10,12H2,1H3,(H2,22,26)/t21-/m0/s1
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4.78n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312821
PNG
(1-[3-cyano-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(cc(c2)-n2nc(C(N)=O)c3cccnc23)C#N)C1=O
Show InChI InChI=1S/C21H16N6O3/c1-26-8-6-21(30,20(26)29)5-4-13-9-14(12-22)11-15(10-13)27-19-16(3-2-7-24-19)17(25-27)18(23)28/h2-3,7,9-11,30H,6,8H2,1H3,(H2,23,28)/t21-/m0/s1
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4.86n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312730
PNG
(5-(cyclopropanecarbonyl)- 1-[3-[2-[(3R)-3-hydroxy-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)C(=O)C2CC2)C1=O
Show InChI InChI=1S/C24H25N5O4/c1-27-12-10-24(33,23(27)32)9-7-15-3-2-4-17(13-15)29-19-8-11-28(22(31)16-5-6-16)14-18(19)20(26-29)21(25)30/h2-4,13,16,33H,5-6,8,10-12,14H2,1H3,(H2,25,30)/t24-/m0/s1
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4.89n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312773
PNG
((6S)-6-hydroxy-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3CC[C@H](O)Cc23)C1=O
Show InChI InChI=1S/C20H21N5O4/c1-24-9-7-20(29,19(24)28)6-4-12-5-8-22-16(10-12)25-15-11-13(26)2-3-14(15)17(23-25)18(21)27/h5,8,10,13,26,29H,2-3,7,9,11H2,1H3,(H2,21,27)/t13-,20-/m0/s1
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5.47n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312747
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cc(cc(c2)C(F)(F)F)-n2nc(C(N)=O)c3cccnc23)C1=O
Show InChI InChI=1S/C21H16F3N5O3/c1-28-8-6-20(32,19(28)31)5-4-12-9-13(21(22,23)24)11-14(10-12)29-18-15(3-2-7-26-18)16(27-29)17(25)30/h2-3,7,9-11,32H,6,8H2,1H3,(H2,25,30)/t20-/m0/s1
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5.53n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312794
PNG
(5-amino-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(cc2N)C(N)=O)C1=O
Show InChI InChI=1S/C16H16N6O3/c1-21-7-5-16(25,15(21)24)4-2-10-3-6-19-13(8-10)22-12(17)9-11(20-22)14(18)23/h3,6,8-9,25H,5,7,17H2,1H3,(H2,18,23)/t16-/m0/s1
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5.87n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312900
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)N2N=C(C3C=NN=CC23)C(N)=O)C1=O
Show InChI InChI=1S/C19H18N6O3/c1-24-8-7-19(28,18(24)27)6-5-12-3-2-4-13(9-12)25-15-11-22-21-10-14(15)16(23-25)17(20)26/h2-4,9-11,14-15,28H,7-8H2,1H3,(H2,20,26)/t14?,15?,19-/m0/s1
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6.80n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312869
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(nc23)C(F)(F)F)C1=O
Show InChI InChI=1S/C20H15F3N6O3/c1-28-8-7-19(32,18(28)31)6-5-11-3-2-4-12(9-11)29-16-13(14(27-29)15(24)30)10-25-17(26-16)20(21,22)23/h2-4,9-10,32H,7-8H2,1H3,(H2,24,30)/t19-/m0/s1
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7.13n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312770
PNG
((R)-1-(4-((3-hydroxy-1-meth- yl-2-oxopyrrolidin-3-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3C4CC(C4)Cc23)C1=O
Show InChI InChI=1S/C21H21N5O3/c1-25-7-5-21(29,20(25)28)4-2-12-3-6-23-16(11-12)26-15-10-13-8-14(9-13)17(15)18(24-26)19(22)27/h3,6,11,13-14,29H,5,7-10H2,1H3,(H2,22,27)/t13?,14?,21-/m0/s1
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7.20n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312895
PNG
(6-chloro-1-[3-[(3R)-3-hydroxy- 3-(5-methyl-1,3,4-o...)
Show SMILES Cc1nnc(o1)[C@](C)(O)C#Cc1cccc(c1)-c1nc(C(N)=O)n2cc(Cl)ccc12
Show InChI InChI=1S/C21H16ClN5O3/c1-12-25-26-20(30-12)21(2,29)9-8-13-4-3-5-14(10-13)17-16-7-6-15(22)11-27(16)19(24-17)18(23)28/h3-7,10-11,29H,1-2H3,(H2,23,28)/t21-/m1/s1
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7.54n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312735
PNG
(4,4-difluoro-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2-o...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3c2CCCC3(F)F)C1=O
Show InChI InChI=1S/C21H20F2N4O3/c1-26-11-10-20(30,19(26)29)9-7-13-4-2-5-14(12-13)27-15-6-3-8-21(22,23)16(15)17(25-27)18(24)28/h2,4-5,12,30H,3,6,8,10-11H2,1H3,(H2,24,28)/t20-/m0/s1
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7.62n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312716
PNG
((4aS,5aR)-1-[4-[2-[(3R)-3- hydroxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3C[C@@H]4C[C@]4(C)Cc23)C1=O
Show InChI InChI=1S/C22H23N5O3/c1-21-11-14(21)10-15-16(12-21)27(25-18(15)19(23)28)17-9-13(4-7-24-17)3-5-22(30)6-8-26(2)20(22)29/h4,7,9,14,30H,6,8,10-12H2,1-2H3,(H2,23,28)/t14-,21-,22+/m1/s1
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7.78n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312881
PNG
(1-[3-[2-[(3R)-3-hydroxy-2- oxo-tetrahydrofuran-3-y...)
Show SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@]2(O)CCOC2=O)c2ccccc12
Show InChI InChI=1S/C20H15N3O4/c21-18(24)17-15-6-1-2-7-16(15)23(22-17)14-5-3-4-13(12-14)8-9-20(26)10-11-27-19(20)25/h1-7,12,26H,10-11H2,(H2,21,24)/t20-/m0/s1
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8.12n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312881
PNG
(1-[3-[2-[(3R)-3-hydroxy-2- oxo-tetrahydrofuran-3-y...)
Show SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@]2(O)CCOC2=O)c2ccccc12
Show InChI InChI=1S/C20H15N3O4/c21-18(24)17-15-6-1-2-7-16(15)23(22-17)14-5-3-4-13(12-14)8-9-20(26)10-11-27-19(20)25/h1-7,12,26H,10-11H2,(H2,21,24)/t20-/m0/s1
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8.12n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312819
PNG
((4R)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES C[C@@H]1CCc2c1c(nn2-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O
Show InChI InChI=1S/C21H22N4O3/c1-13-6-7-16-17(13)18(19(22)26)23-25(16)15-5-3-4-14(12-15)8-9-21(28)10-11-24(2)20(21)27/h3-5,12-13,28H,6-7,10-11H2,1-2H3,(H2,22,26)/t13-,21+/m1/s1
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9.58n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312733
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cccc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c12)C(N)=O
Show InChI InChI=1S/C22H20N4O4/c1-25-12-11-22(29,21(25)28)10-9-14-5-3-6-15(13-14)26-19-16(18(24-26)20(23)27)7-4-8-17(19)30-2/h3-8,13,29H,11-12H2,1-2H3,(H2,23,27)/t22-/m0/s1
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9.75n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312749
PNG
((4S)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3[C@H](CCCc23)n2cccn2)C1=O
Show InChI InChI=1S/C24H24N6O3/c1-28-14-11-24(33,23(28)32)10-9-16-5-2-6-17(15-16)30-19-8-3-7-18(29-13-4-12-26-29)20(19)21(27-30)22(25)31/h2,4-6,12-13,15,18,33H,3,7-8,11,14H2,1H3,(H2,25,31)/t18-,24-/m0/s1
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US Patent
10.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312729
PNG
(5-acetyl-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)C(C)=O)C1=O
Show InChI InChI=1S/C22H23N5O4/c1-14(28)26-10-7-18-17(13-26)19(20(23)29)24-27(18)16-5-3-4-15(12-16)6-8-22(31)9-11-25(2)21(22)30/h3-5,12,31H,7,9-11,13H2,1-2H3,(H2,23,29)/t22-/m0/s1
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US Patent
10.2n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312837
PNG
(1-[3-[2-[(3R,4R)-3,4-dihydroxy- 1-methyl-2-oxo-pyr...)
Show SMILES CN1C[C@@H](O)[C@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O4/c1-24-12-17(26)21(29,20(24)28)10-9-13-5-4-6-14(11-13)25-16-8-3-2-7-15(16)18(23-25)19(22)27/h2-8,11,17,26,29H,12H2,1H3,(H2,22,27)/t17-,21-/m1/s1
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10.2n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312790
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(cc2C)C(N)=O)C1=O
Show InChI InChI=1S/C17H17N5O3/c1-11-9-13(15(18)23)20-22(11)14-10-12(4-7-19-14)3-5-17(25)6-8-21(2)16(17)24/h4,7,9-10,25H,6,8H2,1-2H3,(H2,18,23)/t17-/m0/s1
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10.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312889
PNG
(3-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c3ccc(cn23)C(N)=O)C1=O
Show InChI InChI=1S/C22H19N5O4/c1-26-10-9-22(31,21(26)30)8-7-13-3-2-4-14(11-13)20-25-17(19(24)29)16-6-5-15(18(23)28)12-27(16)20/h2-6,11-12,31H,9-10H2,1H3,(H2,23,28)(H2,24,29)/t22-/m0/s1
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US Patent
11.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312721
PNG
((5S)-5-hydroxy-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3C[C@H](O)C(C)(C)Cc23)C1=O
Show InChI InChI=1S/C22H25N5O4/c1-21(2)12-15-14(11-16(21)28)18(19(23)29)25-27(15)17-10-13(5-8-24-17)4-6-22(31)7-9-26(3)20(22)30/h5,8,10,16,28,31H,7,9,11-12H2,1-3H3,(H2,23,29)/t16-,22-/m0/s1
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US Patent
13.4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312771
PNG
(1-[4-[(3R)-3-hydroxy-3-(5- methylisoxazol-3-yl)but...)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccnc(c1)-n1nc(C(N)=O)c2CCCCc12
Show InChI InChI=1S/C21H21N5O3/c1-13-11-17(25-29-13)21(2,28)9-7-14-8-10-23-18(12-14)26-16-6-4-3-5-15(16)19(24-26)20(22)27/h8,10-12,28H,3-6H2,1-2H3,(H2,22,27)/t21-/m1/s1
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13.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312715
PNG
((4aR,5aS)-1-[4-[2-[(3R)-3- hydroxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3C[C@H]4C[C@@]4(C)Cc23)C1=O
Show InChI InChI=1S/C22H23N5O3/c1-21-11-14(21)10-15-16(12-21)27(25-18(15)19(23)28)17-9-13(4-7-24-17)3-5-22(30)6-8-26(2)20(22)29/h4,7,9,14,30H,6,8,10-12H2,1-2H3,(H2,23,28)/t14-,21-,22-/m0/s1
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13.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312766
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2ccc(n2)C(N)=O)C1=O
Show InChI InChI=1S/C16H15N5O3/c1-20-9-6-16(24,15(20)23)5-2-11-3-7-18-13(10-11)21-8-4-12(19-21)14(17)22/h3-4,7-8,10,24H,6,9H2,1H3,(H2,17,22)/t16-/m0/s1
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14.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312792
PNG
(5-cyclopropyl-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(cc2C2CC2)C(N)=O)C1=O
Show InChI InChI=1S/C19H19N5O3/c1-23-9-7-19(27,18(23)26)6-4-12-5-8-21-16(10-12)24-15(13-2-3-13)11-14(22-24)17(20)25/h5,8,10-11,13,27H,2-3,7,9H2,1H3,(H2,20,25)/t19-/m0/s1
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15.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312741
PNG
(1-[3-[2-[(3S)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O3/c1-24-12-11-21(28,20(24)27)10-9-14-5-4-6-15(13-14)25-17-8-3-2-7-16(17)18(23-25)19(22)26/h2-8,13,28H,11-12H2,1H3,(H2,22,26)/t21-/m1/s1
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16.6n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312828
PNG
(1-[3-[(3S)-3-hydroxy-3-(1H- triazol-4-yl)but-1-yny...)
Show SMILES C[C@](O)(C#Cc1cccc(c1)-n1nc(C(N)=O)c2ccccc12)c1c[nH]nn1
Show InChI InChI=1S/C20H16N6O2/c1-20(28,17-12-22-25-23-17)10-9-13-5-4-6-14(11-13)26-16-8-3-2-7-15(16)18(24-26)19(21)27/h2-8,11-12,28H,1H3,(H2,21,27)(H,22,23,25)/t20-/m0/s1
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16.6n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312789
PNG
(4-chloro-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c(Cl)c2C)C1=O
Show InChI InChI=1S/C17H16ClN5O3/c1-10-13(18)14(15(19)24)21-23(10)12-9-11(4-7-20-12)3-5-17(26)6-8-22(2)16(17)25/h4,7,9,26H,6,8H2,1-2H3,(H2,19,24)/t17-/m0/s1
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16.8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312833
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)[S@@](C)=O)C1=O
Show InChI InChI=1S/C21H23N5O4S/c1-24-11-9-21(29,20(24)28)8-6-14-4-3-5-15(12-14)26-17-7-10-25(31(2)30)13-16(17)18(23-26)19(22)27/h3-5,12,29H,7,9-11,13H2,1-2H3,(H2,22,27)/t21-,31+/m0/s1
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18n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312769
PNG
((R)-1-(4-((3-hydroxy-1-meth- yl-2-oxopyrrolidin-3-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3CC4CC(C4)c23)C1=O
Show InChI InChI=1S/C21H21N5O3/c1-25-7-5-21(29,20(25)28)4-2-12-3-6-23-16(11-12)26-18-14-8-13(9-14)10-15(18)17(24-26)19(22)27/h3,6,11,13-14,29H,5,7-10H2,1H3,(H2,22,27)/t13?,14?,21-/m0/s1
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18.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312835
PNG
(1-[3-[2-[(3S,4S)-3,4-dihydroxy- 1-methyl-2-oxo-pyr...)
Show SMILES CN1C[C@H](O)[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O4/c1-24-12-17(26)21(29,20(24)28)10-9-13-5-4-6-14(11-13)25-16-8-3-2-7-15(16)18(23-25)19(22)27/h2-8,11,17,26,29H,12H2,1H3,(H2,22,27)/t17-,21-/m0/s1
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19.6n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312798
PNG
(7-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3CCNc23)C1=O
Show InChI InChI=1S/C19H19N5O3/c1-23-9-7-19(27,18(23)26)6-5-12-3-2-4-13(11-12)14-16-21-8-10-24(16)17(22-14)15(20)25/h2-4,11,21,27H,7-10H2,1H3,(H2,20,25)/t19-/m0/s1
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20.4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312758
PNG
((5aS)-5,5-difluoro-1-[3-[2- [(3R)-3-hydroxy-1-meth...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CC4[C@](C)(Cc23)C4(F)F)C1=O
Show InChI InChI=1S/C23H22F2N4O3/c1-21-12-16-15(11-17(21)23(21,24)25)18(19(26)30)27-29(16)14-5-3-4-13(10-14)6-7-22(32)8-9-28(2)20(22)31/h3-5,10,17,32H,8-9,11-12H2,1-2H3,(H2,26,30)/t17?,21-,22-/m0/s1
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US Patent
22.6n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312902
PNG
(3-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c3CCCn23)C1=O
Show InChI InChI=1S/C20H20N4O3/c1-23-11-9-20(27,19(23)26)8-7-13-4-2-5-14(12-13)18-22-16(17(21)25)15-6-3-10-24(15)18/h2,4-5,12,27H,3,6,9-11H2,1H3,(H2,21,25)/t20-/m0/s1
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28.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312719
PNG
((5R)-5-hydroxy-1-[4-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3C[C@@H](O)C(C)(C)Cc23)C1=O
Show InChI InChI=1S/C22H25N5O4/c1-21(2)12-15-14(11-16(21)28)18(19(23)29)25-27(15)17-10-13(5-8-24-17)4-6-22(31)7-9-26(3)20(22)30/h5,8,10,16,28,31H,7,9,11-12H2,1-3H3,(H2,23,29)/t16-,22+/m1/s1
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33.2n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312878
PNG
((6S)-6-hydroxy-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CC[C@H](O)c23)C1=O
Show InChI InChI=1S/C20H20N4O4/c1-23-10-9-20(28,19(23)27)8-7-12-3-2-4-13(11-12)24-17-14(5-6-15(17)25)16(22-24)18(21)26/h2-4,11,15,25,28H,5-6,9-10H2,1H3,(H2,21,26)/t15-,20-/m0/s1
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33.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312795
PNG
(3-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c3CCCCn23)C1=O
Show InChI InChI=1S/C21H22N4O3/c1-24-12-10-21(28,20(24)27)9-8-14-5-4-6-15(13-14)19-23-17(18(22)26)16-7-2-3-11-25(16)19/h4-6,13,28H,2-3,7,10-12H2,1H3,(H2,22,26)/t21-/m0/s1
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33.9n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312739
PNG
(1-[3-[(3R)-3-hydroxy-3-pyri- midin-2-yl-but-1-ynyl...)
Show SMILES C[C@@](O)(C#Cc1cccc(c1)-n1nc(C(N)=O)c2ccccc12)c1ncccn1
Show InChI InChI=1S/C22H17N5O2/c1-22(29,21-24-12-5-13-25-21)11-10-15-6-4-7-16(14-15)27-18-9-3-2-8-17(18)19(26-27)20(23)28/h2-9,12-14,29H,1H3,(H2,23,28)/t22-/m1/s1
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35.2n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312740
PNG
(1-[3-[(3R)-3-hydroxy-3-(5- methyl-1,2,4-oxadiazol-...)
Show SMILES Cc1nc(no1)[C@](C)(O)C#Cc1cccc(c1)-n1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C21H17N5O3/c1-13-23-20(25-29-13)21(2,28)11-10-14-6-5-7-15(12-14)26-17-9-4-3-8-16(17)18(24-26)19(22)27/h3-9,12,28H,1-2H3,(H2,22,27)/t21-/m1/s1
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36.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312717
PNG
((5S)-5-benzyloxy-1-[4-[2-[(3R)- 3-hydroxy-1-methyl...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3C[C@H](OCc4ccccc4)C(C)(C)Cc23)C1=O
Show InChI InChI=1S/C29H31N5O4/c1-28(2)17-22-21(16-23(28)38-18-20-7-5-4-6-8-20)25(26(30)35)32-34(22)24-15-19(10-13-31-24)9-11-29(37)12-14-33(3)27(29)36/h4-8,10,13,15,23,37H,12,14,16-18H2,1-3H3,(H2,30,35)/t23-,29-/m0/s1
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45.5n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312834
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)[S@](C)=O)C1=O
Show InChI InChI=1S/C21H23N5O4S/c1-24-11-9-21(29,20(24)28)8-6-14-4-3-5-15(12-14)26-17-7-10-25(31(2)30)13-16(17)18(23-26)19(22)27/h3-5,12,29H,7,9-11,13H2,1-2H3,(H2,22,27)/t21-,31-/m0/s1
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46.4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312759
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(CN4CCCC4)ccc23)C1=O
Show InChI InChI=1S/C26H27N5O3/c1-29-14-11-26(34,25(29)33)10-9-18-5-4-6-20(15-18)31-22-8-7-19(17-30-12-2-3-13-30)16-21(22)23(28-31)24(27)32/h4-8,15-16,34H,2-3,11-14,17H2,1H3,(H2,27,32)/t26-/m0/s1
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64.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312751
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CC(C)(C)O)CCc23)C1=O
Show InChI InChI=1S/C24H29N5O4/c1-23(2,32)15-28-11-8-19-18(14-28)20(21(25)30)26-29(19)17-6-4-5-16(13-17)7-9-24(33)10-12-27(3)22(24)31/h4-6,13,32-33H,8,10-12,14-15H2,1-3H3,(H2,25,30)/t24-/m0/s1
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71n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312718
PNG
((5R)-5-benzyloxy-1-[4-[2-[(3R)- 3-hydroxy-1-methyl...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3C[C@@H](OCc4ccccc4)C(C)(C)Cc23)C1=O
Show InChI InChI=1S/C29H31N5O4/c1-28(2)17-22-21(16-23(28)38-18-20-7-5-4-6-8-20)25(26(30)35)32-34(22)24-15-19(10-13-31-24)9-11-29(37)12-14-33(3)27(29)36/h4-8,10,13,15,23,37H,12,14,16-18H2,1-3H3,(H2,30,35)/t23-,29+/m1/s1
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72.4n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312791
PNG
(1-[4-[(3R)-3-hydroxy-3-(5- methylisoxazol-3-yl)but...)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccnc(c1)-n1nc(cc1C)C(N)=O
Show InChI InChI=1S/C18H17N5O3/c1-11-8-14(17(19)24)21-23(11)16-10-13(5-7-20-16)4-6-18(3,25)15-9-12(2)26-22-15/h5,7-10,25H,1-3H3,(H2,19,24)/t18-/m1/s1
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84.5n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312825
PNG
(1-[3-[2-[(1S)-1-hydroxy-2- oxo-cyclopentyl]ethynyl...)
Show SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@@]2(O)CCCC2=O)c2ccccc12
Show InChI InChI=1S/C21H17N3O3/c22-20(26)19-16-7-1-2-8-17(16)24(23-19)15-6-3-5-14(13-15)10-12-21(27)11-4-9-18(21)25/h1-3,5-8,13,27H,4,9,11H2,(H2,22,26)/t21-/m0/s1
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86.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312793
PNG
(4-chloro-1-[4-[(3R)-3-hydroxy- 3-(5-methylisoxazol...)
Show SMILES Cc1cc(no1)[C@](C)(O)C#Cc1ccnc(c1)-n1nc(C(N)=O)c(Cl)c1C
Show InChI InChI=1S/C18H16ClN5O3/c1-10-8-13(23-27-10)18(3,26)6-4-12-5-7-21-14(9-12)24-11(2)15(19)16(22-24)17(20)25/h5,7-9,26H,1-3H3,(H2,20,25)/t18-/m1/s1
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99.1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312894
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN(C)C(=O)c1ccc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O
Show InChI InChI=1S/C24H23N5O4/c1-27(2)22(31)16-7-8-19-18(14-16)20(21(25)30)26-29(19)17-6-4-5-15(13-17)9-10-24(33)11-12-28(3)23(24)32/h4-8,13-14,33H,11-12H2,1-3H3,(H2,25,30)/t24-/m0/s1
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103n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312727
PNG
((4S)-4-(cyclopropanecarbo- nylamino)-1-[4-[2-[(3R)...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3[C@H](CCCc23)NC(=O)C2CC2)C1=O
Show InChI InChI=1S/C24H26N6O4/c1-29-12-10-24(34,23(29)33)9-7-14-8-11-26-18(13-14)30-17-4-2-3-16(27-22(32)15-5-6-15)19(17)20(28-30)21(25)31/h8,11,13,15-16,34H,2-6,10,12H2,1H3,(H2,25,31)(H,27,32)/t16-,24-/m0/s1
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146n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312761
PNG
((5aR)-5,5-difluoro-1-[3-[2- [(3R)-3-hydroxy-1-meth...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CC4[C@@](C)(Cc23)C4(F)F)C1=O
Show InChI InChI=1S/C23H22F2N4O3/c1-21-12-16-15(11-17(21)23(21,24)25)18(19(26)30)27-29(16)14-5-3-4-13(10-14)6-7-22(32)8-9-28(2)20(22)31/h3-5,10,17,32H,8-9,11-12H2,1-2H3,(H2,26,30)/t17?,21-,22+/m1/s1
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170n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312748
PNG
((4S)-4-(cyclopropanecarbo- nylamino)-1-[3-[2-[(3R)...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3[C@H](CCCc23)NC(=O)C2CC2)C1=O
Show InChI InChI=1S/C25H27N5O4/c1-29-13-12-25(34,24(29)33)11-10-15-4-2-5-17(14-15)30-19-7-3-6-18(27-23(32)16-8-9-16)20(19)21(28-30)22(26)31/h2,4-5,14,16,18,34H,3,6-9,12-13H2,1H3,(H2,26,31)(H,27,32)/t18-,25-/m0/s1
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193n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312731
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CNCCc23)C1=O
Show InChI InChI=1S/C20H21N5O3/c1-24-10-8-20(28,19(24)27)7-5-13-3-2-4-14(11-13)25-16-6-9-22-12-15(16)17(23-25)18(21)26/h2-4,11,22,28H,6,8-10,12H2,1H3,(H2,21,26)/t20-/m0/s1
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233n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312779
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)N2N=C(C3CCS(=O)(=O)CC23)C(N)=O)C1=O
Show InChI InChI=1S/C20H22N4O5S/c1-23-9-8-20(27,19(23)26)7-5-13-3-2-4-14(11-13)24-16-12-30(28,29)10-6-15(16)17(22-24)18(21)25/h2-4,11,15-16,27H,6,8-10,12H2,1H3,(H2,21,25)/t15?,16?,20-/m0/s1
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237n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312873
PNG
(1-[3-[4-(dimethyalmino)-3- hydroxy-4-oxo-but-1-yny...)
Show SMILES CN(C)C(=O)C(O)C#Cc1cccc(c1)-n1nc(C(N)=O)c2ccccc12
Show InChI InChI=1S/C20H18N4O3/c1-23(2)20(27)17(25)11-10-13-6-5-7-14(12-13)24-16-9-4-3-8-15(16)18(22-24)19(21)26/h3-9,12,17,25H,1-2H3,(H2,21,26)
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250n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312744
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3CN(CCc23)C2COC2)C1=O
Show InChI InChI=1S/C23H25N5O4/c1-26-10-8-23(31,22(26)30)7-5-15-3-2-4-16(11-15)28-19-6-9-27(17-13-32-14-17)12-18(19)20(25-28)21(24)29/h2-4,11,17,31H,6,8-10,12-14H2,1H3,(H2,24,29)/t23-/m0/s1
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259n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312725
PNG
((4R)-4-(cyclopropanecarbo- nylamino)-1-[4-[2-[(3R)...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3[C@@H](CCCc23)NC(=O)C2CC2)C1=O
Show InChI InChI=1S/C24H26N6O4/c1-29-12-10-24(34,23(29)33)9-7-14-8-11-26-18(13-14)30-17-4-2-3-16(27-22(32)15-5-6-15)19(17)20(28-30)21(25)31/h8,11,13,15-16,34H,2-6,10,12H2,1H3,(H2,25,31)(H,27,32)/t16-,24+/m1/s1
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382n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312882
PNG
(1-[3-[2-[(3)S-3-hydroxy-2- oxo-tetrahydrofuran-3-y...)
Show SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@@]2(O)CCOC2=O)c2ccccc12
Show InChI InChI=1S/C20H15N3O4/c21-18(24)17-15-6-1-2-7-16(15)23(22-17)14-5-3-4-13(12-14)8-9-20(26)10-11-27-19(20)25/h1-7,12,26H,10-11H2,(H2,21,24)/t20-/m1/s1
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473n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312836
PNG
(1-[3-[2-[(3S,4R)-3,4-dihydroxy- 1-methyl-2-oxo-pyr...)
Show SMILES CN1C[C@@H](O)[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O4/c1-24-12-17(26)21(29,20(24)28)10-9-13-5-4-6-14(11-13)25-16-8-3-2-7-15(16)18(23-25)19(22)27/h2-8,11,17,26,29H,12H2,1H3,(H2,22,27)/t17-,21+/m1/s1
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591n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312745
PNG
((4R)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3[C@@H](CCCc23)n2cccn2)C1=O
Show InChI InChI=1S/C24H24N6O3/c1-28-14-11-24(33,23(28)32)10-9-16-5-2-6-17(15-16)30-19-8-3-7-18(29-13-4-12-26-29)20(19)21(27-30)22(25)31/h2,4-6,12-13,15,18,33H,3,7-8,11,14H2,1H3,(H2,25,31)/t18-,24+/m1/s1
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606n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312743
PNG
((4R)-4-(cyclopropanecarbonyl- amino)-1-[3-[2-[(3R)...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3[C@@H](CCCc23)NC(=O)C2CC2)C1=O
Show InChI InChI=1S/C25H27N5O4/c1-29-13-12-25(34,24(29)33)11-10-15-4-2-5-17(14-15)30-19-7-3-6-18(27-23(32)16-8-9-16)20(19)21(28-30)22(26)31/h2,4-5,14,16,18,34H,3,6-9,12-13H2,1H3,(H2,26,31)(H,27,32)/t18-,25+/m1/s1
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1.04E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312844
PNG
(6-cyano-1-[3-[2-[(7R)-7-hy- droxy-5,6-dihydrocyclo...)
Show SMILES NC(=O)c1nn(-c2cccc(c2)C#C[C@]2(O)CCc3cccnc23)c2cc(ncc12)C#N
Show InChI InChI=1S/C24H16N6O2/c25-13-17-12-20-19(14-28-17)21(23(26)31)29-30(20)18-5-1-3-15(11-18)6-8-24(32)9-7-16-4-2-10-27-22(16)24/h1-5,10-12,14,32H,7,9H2,(H2,26,31)/t24-/m0/s1
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1.25E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (human))
BDBM312838
PNG
(1-[3-[2-[(3R,4S)-3,4-dihydroxy- 1-methyl-2-oxo-pyr...)
Show SMILES CN1C[C@H](O)[C@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O
Show InChI InChI=1S/C21H18N4O4/c1-24-12-17(26)21(29,20(24)28)10-9-13-5-4-6-14(11-13)25-16-8-3-2-7-15(16)18(23-25)19(22)27/h2-8,11,17,26,29H,12H2,1H3,(H2,22,27)/t17-,21+/m0/s1
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1.25E+3n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...


US Patent US9605005 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%