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Patent code US9605024

Compile Data Set for Download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175975
PNG
(US10047103, 8 | US9605024, Example 8 | US9688695, ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3nnc(s3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H17N5O4S2/c1-29-14-8-17(31-12-20-25-26-21(33-20)13-6-4-3-5-7-13)15-10-19(32-18(15)9-14)16-11-28-22(24-16)34-23(27-28)30-2/h3-11H,12H2,1-2H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.90n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175970
PNG
(US10047103, 3 | US9605024, Example 3 | US9688695, ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C24H18N4O4S2/c1-29-16-8-19(31-12-15-13-33-22(25-15)14-6-4-3-5-7-14)17-10-21(32-20(17)9-16)18-11-28-23(26-18)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/an/an/a 0.320n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175985
PNG
(US10047103, 18 | US9605024, Example 18 | US9688695...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(OC)cc3)cc(OC)cc2o1
Show InChI InChI=1S/C25H20N4O5S2/c1-30-16-6-4-14(5-7-16)23-26-15(13-35-23)12-33-20-8-17(31-2)9-21-18(20)10-22(34-21)19-11-29-24(27-19)36-25(28-29)32-3/h4-11,13H,12H2,1-3H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175976
PNG
(US10047103, 9 | US9605024, Example 9 | US9688695, ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cn(nn3)-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H18N6O4S/c1-30-16-8-19(32-13-14-11-28(27-25-14)15-6-4-3-5-7-15)17-10-21(33-20(17)9-16)18-12-29-22(24-18)34-23(26-29)31-2/h3-12H,13H2,1-2H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.30n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176146
PNG
(US10047103, 179 | US9605024, Example 36 | US968869...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccccc3)cc(F)cc2o1
Show InChI InChI=1S/C23H15FN4O3S2/c1-29-23-27-28-10-17(26-22(28)33-23)20-9-16-18(7-14(24)8-19(16)31-20)30-11-15-12-32-21(25-15)13-5-3-2-4-6-13/h2-10,12H,11H2,1H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM176000
PNG
(US10047103, 33 | US9605024, Example 33 | US9688695...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3cc(C)on3)cc(OC)cc2o1
Show InChI InChI=1S/C22H17N5O5S2/c1-11-4-15(26-32-11)20-23-12(10-33-20)9-30-17-5-13(28-2)6-18-14(17)7-19(31-18)16-8-27-21(24-16)34-22(25-27)29-3/h4-8,10H,9H2,1-3H3
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.70n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175977
PNG
(US10047103, 10 | US9605024, Example 10 | US9688695...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3cnnn3-c3ccccc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H18N6O4S/c1-30-16-8-19(32-13-15-11-24-27-29(15)14-6-4-3-5-7-14)17-10-21(33-20(17)9-16)18-12-28-22(25-18)34-23(26-28)31-2/h3-12H,13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3.5n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175995
PNG
(US10047103, 75 | US9605024, Example 28 | US9688695...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccncc3)cc(OC)cc2o1
Show InChI InChI=1S/C23H17N5O4S2/c1-29-15-7-18(31-11-14-12-33-21(25-14)13-3-5-24-6-4-13)16-9-20(32-19(16)8-15)17-10-28-22(26-17)34-23(27-28)30-2/h3-10,12H,11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.510n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM175969
PNG
(US10047103, 2 | US9605024, Example 2 | US9688695, ...)
Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)C(F)(F)F)cc(OC)cc2o1
Show InChI InChI=1S/C19H13F3N4O4S2/c1-27-10-3-13(29-7-9-8-31-16(23-9)19(20,21)22)11-5-15(30-14(11)4-10)12-6-26-17(24-12)32-18(25-26)28-2/h3-6,8H,7H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.420n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...


US Patent US9605024 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%