BindingDB logo
myBDB logout

Patent code US9610299

Compile Data Set for Download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153690
PNG
(US9000015, 7 | US9610299, Example 7)
Show SMILES Fc1ccc(F)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H13ClF2N2O2/c20-18-15(22)6-5-14(21)17(18)19(26)24-10-11-1-3-12(4-2-11)13-7-8-23-16(25)9-13/h1-9H,10H2,(H,23,25)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 23n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153696
PNG
(US9000015, 13 | US9610299, Example 13)
Show SMILES Fc1c[nH]c(=O)cc1-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C19H13Cl2FN2O2/c20-14-2-1-3-15(21)18(14)19(26)24-9-11-4-6-12(7-5-11)13-8-17(25)23-10-16(13)22/h1-8,10H,9H2,(H,23,25)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153684
PNG
(US9000015, 1 | US9610299, Example 1)
Show SMILES COCCOc1cc(Cl)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C22H20Cl2N2O4/c1-29-8-9-30-17-11-18(23)21(19(24)12-17)22(28)26-13-14-2-4-15(5-3-14)16-6-7-25-20(27)10-16/h2-7,10-12H,8-9,13H2,1H3,(H,25,27)(H,26,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153685
PNG
(US9000015, 2 | US9610299, Example 2)
Show SMILES Clc1cccc(Cl)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14Cl2N2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 102n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153697
PNG
(US9000015, 14 | US9610299, Example 14)
Show SMILES OP(O)(=O)OCn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H17Cl2N2O6P/c21-16-2-1-3-17(22)19(16)20(26)23-11-13-4-6-14(7-5-13)15-8-9-24(18(25)10-15)12-30-31(27,28)29/h1-10H,11-12H2,(H,23,26)(H2,27,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 166n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153686
PNG
(US9000015, 3 | US9610299, Example 3)
Show SMILES Fc1cccc(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H14ClFN2O2/c20-18-15(2-1-3-16(18)21)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 215n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153695
PNG
(US9000015, 12 | US9610299, Example 12)
Show SMILES Fc1cc(ccc1CNC(=O)c1c(Cl)cccc1Cl)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13Cl2FN2O2/c20-14-2-1-3-15(21)18(14)19(26)24-10-13-5-4-11(8-16(13)22)12-6-7-23-17(25)9-12/h1-9H,10H2,(H,23,25)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 304n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153694
PNG
(US9000015, 11 | US9610299, Example 11)
Show SMILES Fc1cccc(Cl)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 379n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153690
PNG
(US9000015, 7 | US9610299, Example 7)
Show SMILES Fc1ccc(F)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H13ClF2N2O2/c20-18-15(22)6-5-14(21)17(18)19(26)24-10-11-1-3-12(4-2-11)13-7-8-23-16(25)9-13/h1-9H,10H2,(H,23,25)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 464n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153691
PNG
(US9000015, 8 | US9610299, Example 8)
Show SMILES Cc1cc(CNC(=O)c2c(Cl)cccc2Cl)ccc1-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H16Cl2N2O2/c1-12-9-13(5-6-15(12)14-7-8-23-18(25)10-14)11-24-20(26)19-16(21)3-2-4-17(19)22/h2-10H,11H2,1H3,(H,23,25)(H,24,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 480n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153693
PNG
(US9000015, 10 | US9610299, Example 10)
Show SMILES Fc1cccc(F)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14F2N2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 890n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM314091
PNG
(2,6-dimethyl-N-(4-(2-oxopiperidin-4-yl)benzyl)benz...)
Show SMILES Cc1cccc(C)c1C(=O)NCc1ccc(cc1)C1CCNC(=O)C1
Show InChI InChI=1S/C21H24N2O2/c1-14-4-3-5-15(2)20(14)21(25)23-13-16-6-8-17(9-7-16)18-10-11-22-19(24)12-18/h3-9,18H,10-13H2,1-2H3,(H,22,24)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.11E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153692
PNG
(US9000015, 9 | US9610299, Example 9)
Show SMILES Cn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H16Cl2N2O2/c1-24-10-9-15(11-18(24)25)14-7-5-13(6-8-14)12-23-20(26)19-16(21)3-2-4-17(19)22/h2-11H,12H2,1H3,(H,23,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.09E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Aldehyde dehydrogenase (ALDH2)


(Homo sapiens (Human))
BDBM153697
PNG
(US9000015, 14 | US9610299, Example 14)
Show SMILES OP(O)(=O)OCn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H17Cl2N2O6P/c21-16-2-1-3-17(22)19(16)20(26)23-11-13-4-6-14(7-5-13)15-8-9-24(18(25)10-15)12-30-31(27,28)29/h1-10H,11-12H2,(H,23,26)(H2,27,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153697
PNG
(US9000015, 14 | US9610299, Example 14)
Show SMILES OP(O)(=O)OCn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H17Cl2N2O6P/c21-16-2-1-3-17(22)19(16)20(26)23-11-13-4-6-14(7-5-13)15-8-9-24(18(25)10-15)12-30-31(27,28)29/h1-10H,11-12H2,(H,23,26)(H2,27,28,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153694
PNG
(US9000015, 11 | US9610299, Example 11)
Show SMILES Fc1cccc(Cl)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153696
PNG
(US9000015, 13 | US9610299, Example 13)
Show SMILES Fc1c[nH]c(=O)cc1-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C19H13Cl2FN2O2/c20-14-2-1-3-15(21)18(14)19(26)24-9-11-4-6-12(7-5-11)13-8-17(25)23-10-16(13)22/h1-8,10H,9H2,(H,23,25)(H,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153685
PNG
(US9000015, 2 | US9610299, Example 2)
Show SMILES Clc1cccc(Cl)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14Cl2N2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153685
PNG
(US9000015, 2 | US9610299, Example 2)
Show SMILES Clc1cccc(Cl)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14Cl2N2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153690
PNG
(US9000015, 7 | US9610299, Example 7)
Show SMILES Fc1ccc(F)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H13ClF2N2O2/c20-18-15(22)6-5-14(21)17(18)19(26)24-10-11-1-3-12(4-2-11)13-7-8-23-16(25)9-13/h1-9H,10H2,(H,23,25)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153691
PNG
(US9000015, 8 | US9610299, Example 8)
Show SMILES Cc1cc(CNC(=O)c2c(Cl)cccc2Cl)ccc1-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H16Cl2N2O2/c1-12-9-13(5-6-15(12)14-7-8-23-18(25)10-14)11-24-20(26)19-16(21)3-2-4-17(19)22/h2-10H,11H2,1H3,(H,23,25)(H,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153695
PNG
(US9000015, 12 | US9610299, Example 12)
Show SMILES Fc1cc(ccc1CNC(=O)c1c(Cl)cccc1Cl)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13Cl2FN2O2/c20-14-2-1-3-15(21)18(14)19(26)24-10-13-5-4-11(8-16(13)22)12-6-7-23-17(25)9-12/h1-9H,10H2,(H,23,25)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153697
PNG
(US9000015, 14 | US9610299, Example 14)
Show SMILES OP(O)(=O)OCn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H17Cl2N2O6P/c21-16-2-1-3-17(22)19(16)20(26)23-11-13-4-6-14(7-5-13)15-8-9-24(18(25)10-15)12-30-31(27,28)29/h1-10H,11-12H2,(H,23,26)(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153690
PNG
(US9000015, 7 | US9610299, Example 7)
Show SMILES Fc1ccc(F)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H13ClF2N2O2/c20-18-15(22)6-5-14(21)17(18)19(26)24-10-11-1-3-12(4-2-11)13-7-8-23-16(25)9-13/h1-9H,10H2,(H,23,25)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153690
PNG
(US9000015, 7 | US9610299, Example 7)
Show SMILES Fc1ccc(F)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H13ClF2N2O2/c20-18-15(22)6-5-14(21)17(18)19(26)24-10-11-1-3-12(4-2-11)13-7-8-23-16(25)9-13/h1-9H,10H2,(H,23,25)(H,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153692
PNG
(US9000015, 9 | US9610299, Example 9)
Show SMILES Cn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H16Cl2N2O2/c1-24-10-9-15(11-18(24)25)14-7-5-13(6-8-14)12-23-20(26)19-16(21)3-2-4-17(19)22/h2-11H,12H2,1H3,(H,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153693
PNG
(US9000015, 10 | US9610299, Example 10)
Show SMILES Fc1cccc(F)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14F2N2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153697
PNG
(US9000015, 14 | US9610299, Example 14)
Show SMILES OP(O)(=O)OCn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H17Cl2N2O6P/c21-16-2-1-3-17(22)19(16)20(26)23-11-13-4-6-14(7-5-13)15-8-9-24(18(25)10-15)12-30-31(27,28)29/h1-10H,11-12H2,(H,23,26)(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153695
PNG
(US9000015, 12 | US9610299, Example 12)
Show SMILES Fc1cc(ccc1CNC(=O)c1c(Cl)cccc1Cl)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H13Cl2FN2O2/c20-14-2-1-3-15(21)18(14)19(26)24-10-13-5-4-11(8-16(13)22)12-6-7-23-17(25)9-12/h1-9H,10H2,(H,23,25)(H,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153693
PNG
(US9000015, 10 | US9610299, Example 10)
Show SMILES Fc1cccc(F)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14F2N2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM314091
PNG
(2,6-dimethyl-N-(4-(2-oxopiperidin-4-yl)benzyl)benz...)
Show SMILES Cc1cccc(C)c1C(=O)NCc1ccc(cc1)C1CCNC(=O)C1
Show InChI InChI=1S/C21H24N2O2/c1-14-4-3-5-15(2)20(14)21(25)23-13-16-6-8-17(9-7-16)18-10-11-22-19(24)12-18/h3-9,18H,10-13H2,1-2H3,(H,22,24)(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153697
PNG
(US9000015, 14 | US9610299, Example 14)
Show SMILES OP(O)(=O)OCn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H17Cl2N2O6P/c21-16-2-1-3-17(22)19(16)20(26)23-11-13-4-6-14(7-5-13)15-8-9-24(18(25)10-15)12-30-31(27,28)29/h1-10H,11-12H2,(H,23,26)(H2,27,28,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153684
PNG
(US9000015, 1 | US9610299, Example 1)
Show SMILES COCCOc1cc(Cl)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C22H20Cl2N2O4/c1-29-8-9-30-17-11-18(23)21(19(24)12-17)22(28)26-13-14-2-4-15(5-3-14)16-6-7-25-20(27)10-16/h2-7,10-12H,8-9,13H2,1H3,(H,25,27)(H,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153694
PNG
(US9000015, 11 | US9610299, Example 11)
Show SMILES Fc1cccc(Cl)c1C(=O)NCc1ccc(cc1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O2/c20-15-2-1-3-16(21)18(15)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153691
PNG
(US9000015, 8 | US9610299, Example 8)
Show SMILES Cc1cc(CNC(=O)c2c(Cl)cccc2Cl)ccc1-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C20H16Cl2N2O2/c1-12-9-13(5-6-15(12)14-7-8-23-18(25)10-14)11-24-20(26)19-16(21)3-2-4-17(19)22/h2-10H,11H2,1H3,(H,23,25)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM314091
PNG
(2,6-dimethyl-N-(4-(2-oxopiperidin-4-yl)benzyl)benz...)
Show SMILES Cc1cccc(C)c1C(=O)NCc1ccc(cc1)C1CCNC(=O)C1
Show InChI InChI=1S/C21H24N2O2/c1-14-4-3-5-15(2)20(14)21(25)23-13-16-6-8-17(9-7-16)18-10-11-22-19(24)12-18/h3-9,18H,10-13H2,1-2H3,(H,22,24)(H,23,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153690
PNG
(US9000015, 7 | US9610299, Example 7)
Show SMILES Fc1ccc(F)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H13ClF2N2O2/c20-18-15(22)6-5-14(21)17(18)19(26)24-10-11-1-3-12(4-2-11)13-7-8-23-16(25)9-13/h1-9H,10H2,(H,23,25)(H,24,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153686
PNG
(US9000015, 3 | US9610299, Example 3)
Show SMILES Fc1cccc(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H14ClFN2O2/c20-18-15(2-1-3-16(18)21)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153684
PNG
(US9000015, 1 | US9610299, Example 1)
Show SMILES COCCOc1cc(Cl)c(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C22H20Cl2N2O4/c1-29-8-9-30-17-11-18(23)21(19(24)12-17)22(28)26-13-14-2-4-15(5-3-14)16-6-7-25-20(27)10-16/h2-7,10-12H,8-9,13H2,1H3,(H,25,27)(H,26,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153696
PNG
(US9000015, 13 | US9610299, Example 13)
Show SMILES Fc1c[nH]c(=O)cc1-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C19H13Cl2FN2O2/c20-14-2-1-3-15(21)18(14)19(26)24-9-11-4-6-12(7-5-11)13-8-17(25)23-10-16(13)22/h1-8,10H,9H2,(H,23,25)(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153686
PNG
(US9000015, 3 | US9610299, Example 3)
Show SMILES Fc1cccc(C(=O)NCc2ccc(cc2)-c2cc[nH]c(=O)c2)c1Cl
Show InChI InChI=1S/C19H14ClFN2O2/c20-18-15(2-1-3-16(18)21)19(25)23-11-12-4-6-13(7-5-12)14-8-9-22-17(24)10-14/h1-10H,11H2,(H,22,24)(H,23,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Homo sapiens (Human))
BDBM153692
PNG
(US9000015, 9 | US9610299, Example 9)
Show SMILES Cn1ccc(cc1=O)-c1ccc(CNC(=O)c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H16Cl2N2O2/c1-24-10-9-15(11-18(24)25)14-7-5-13(6-8-14)12-23-20(26)19-16(21)3-2-4-17(19)22/h2-11H,12H2,1H3,(H,23,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>1.30E+5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...


US Patent US9610299 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%