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Patent code US9611221

Compile Data Set for Download or QSAR
Found 199 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314121
PNG
(3-[(4-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-11-1-3-12(4-2-11)13-5-6-13/h1-4,7-8,10,13,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314126
PNG
(3-[(2-cyclopropyl-3-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1cccc(CNc2cnccc2C(O)=O)c1C1CC1
Show InChI InChI=1S/C17H18N2O2/c1-11-3-2-4-13(16(11)12-5-6-12)9-19-15-10-18-8-7-14(15)17(20)21/h2-4,7-8,10,12,19H,5-6,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314127
PNG
(3-{[(4-cyclopropylpyridin-3-yl)-methyl]amino}pyrid...)
Show SMILES OC(=O)c1ccncc1NCc1cnccc1C1CC1
Show InChI InChI=1S/C15H15N3O2/c19-15(20)13-4-6-17-9-14(13)18-8-11-7-16-5-3-12(11)10-1-2-10/h3-7,9-10,18H,1-2,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50153334
PNG
(CHEMBL3774545 | US10179769, Example 39 | US9611221...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)s1
Show InChI InChI=1S/C12H12N2O2S/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314140
PNG
(3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]p...)
Show SMILES OC(=O)c1ccncc1NCC1COc2ccccc2O1
Show InChI InChI=1S/C15H14N2O4/c18-15(19)11-5-6-16-8-12(11)17-7-10-9-20-13-3-1-2-4-14(13)21-10/h1-6,8,10,17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314148
PNG
(3-{[(7-cyclopropyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)C1CC1
Show InChI InChI=1S/C20H22N2O2/c23-20(24)17-8-9-21-12-19(17)22-11-16-3-1-2-14-6-7-15(10-18(14)16)13-4-5-13/h6-10,12-13,16,22H,1-5,11H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314117
PNG
(3-[(4-chloro-2-hydroxybenzyl)amino]pyridine-4-carb...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1O
Show InChI InChI=1S/C13H11ClN2O3/c14-9-2-1-8(12(17)5-9)6-16-11-7-15-4-3-10(11)13(18)19/h1-5,7,16-17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314124
PNG
(3-[(naphthalene-1-ylmethyl)amino]pyridine-4-carbox...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-9,11,19H,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314124
PNG
(3-[(naphthalene-1-ylmethyl)amino]pyridine-4-carbox...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-9,11,19H,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314126
PNG
(3-[(2-cyclopropyl-3-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1cccc(CNc2cnccc2C(O)=O)c1C1CC1
Show InChI InChI=1S/C17H18N2O2/c1-11-3-2-4-13(16(11)12-5-6-12)9-19-15-10-18-8-7-14(15)17(20)21/h2-4,7-8,10,12,19H,5-6,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314127
PNG
(3-{[(4-cyclopropylpyridin-3-yl)-methyl]amino}pyrid...)
Show SMILES OC(=O)c1ccncc1NCc1cnccc1C1CC1
Show InChI InChI=1S/C15H15N3O2/c19-15(20)13-4-6-17-9-14(13)18-8-11-7-16-5-3-12(11)10-1-2-10/h3-7,9-10,18H,1-2,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314136
PNG
(3-{[(5-methylfuran-2-yl)methyl]amino}pyridine-4-ca...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)o1
Show InChI InChI=1S/C12H12N2O3/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314137
PNG
(3-[(1-benzofuran-2-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1cc2ccccc2o1
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-7,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314140
PNG
(3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]p...)
Show SMILES OC(=O)c1ccncc1NCC1COc2ccccc2O1
Show InChI InChI=1S/C15H14N2O4/c18-15(19)11-5-6-16-8-12(11)17-7-10-9-20-13-3-1-2-4-14(13)21-10/h1-6,8,10,17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314142
PNG
(3-[(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)amino]...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314116
PNG
(3-[(4-chloro-2-methoxybenzyl)amino]pyridine-4-carb...)
Show SMILES COc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O3/c1-20-13-6-10(15)3-2-9(13)7-17-12-8-16-5-4-11(12)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314116
PNG
(3-[(4-chloro-2-methoxybenzyl)amino]pyridine-4-carb...)
Show SMILES COc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O3/c1-20-13-6-10(15)3-2-9(13)7-17-12-8-16-5-4-11(12)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314124
PNG
(3-[(naphthalene-1-ylmethyl)amino]pyridine-4-carbox...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2ccccc12
Show InChI InChI=1S/C17H14N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-9,11,19H,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314130
PNG
(3-[(2-cyclopropyl-5-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1ccc(C2CC2)c(CNc2cnccc2C(O)=O)c1
Show InChI InChI=1S/C17H18N2O2/c1-11-2-5-14(12-3-4-12)13(8-11)9-19-16-10-18-7-6-15(16)17(20)21/h2,5-8,10,12,19H,3-4,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM50153334
PNG
(CHEMBL3774545 | US10179769, Example 39 | US9611221...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)s1
Show InChI InChI=1S/C12H12N2O2S/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314139
PNG
(3-[(2,3-dihydro-1-benzofuran-2-ylmethyl)amino]pyri...)
Show SMILES OC(=O)c1ccncc1NCC1Cc2ccccc2O1
Show InChI InChI=1S/C15H14N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-6,9,11,17H,7-8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314145
PNG
(3-{[(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(F)cc12
Show InChI InChI=1S/C17H17FN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314156
PNG
(3-{[(6-methyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES Cc1ccc2OCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-11-2-3-16-14(8-11)12(5-7-22-16)9-19-15-10-18-6-4-13(15)17(20)21/h2-4,6,8,10,12,19H,5,7,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314119
PNG
(3-[(4-bromobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314122
PNG
(3-[(4-chloro-2-cyclopropylbenzyl)amino]pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1C1CC1
Show InChI InChI=1S/C16H15ClN2O2/c17-12-4-3-11(14(7-12)10-1-2-10)8-19-15-9-18-6-5-13(15)16(20)21/h3-7,9-10,19H,1-2,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314123
PNG
(3-{[2-cyclopropyl-4-(trifluoromethyl)benzyl]amino}...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1C1CC1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N2O2/c18-17(19,20)12-4-3-11(14(7-12)10-1-2-10)8-22-15-9-21-6-5-13(15)16(23)24/h3-7,9-10,22H,1-2,8H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314125
PNG
(3-[(1H-indol-7-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2cc[nH]c12
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314125
PNG
(3-[(1H-indol-7-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2cc[nH]c12
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314126
PNG
(3-[(2-cyclopropyl-3-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1cccc(CNc2cnccc2C(O)=O)c1C1CC1
Show InChI InChI=1S/C17H18N2O2/c1-11-3-2-4-13(16(11)12-5-6-12)9-19-15-10-18-8-7-14(15)17(20)21/h2-4,7-8,10,12,19H,5-6,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314134
PNG
(3-[(1-benzofuran-3-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1coc2ccccc12
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-8-13(12)17-7-10-9-20-14-4-2-1-3-11(10)14/h1-6,8-9,17H,7H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314137
PNG
(3-[(1-benzofuran-2-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1cc2ccccc2o1
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-7,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314141
PNG
(3-[(2,3-dihydro-1H-inden-1-ylmethylbenzyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCc2ccccc12
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-6-5-11-3-1-2-4-13(11)12/h1-4,7-8,10,12,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314142
PNG
(3-[(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)amino]...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314152
PNG
(3-[(3,4-dihydro-2H-chromen-4-ylmethyl)amino]pyridi...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314154
PNG
(3-{[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314118
PNG
(3-[(2-aminobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES Nc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C13H13N3O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7,14H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314118
PNG
(3-[(2-aminobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES Nc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C13H13N3O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7,14H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314120
PNG
(3-[(4-methylbenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O2/c1-10-2-4-11(5-3-10)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314120
PNG
(3-[(4-methylbenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O2/c1-10-2-4-11(5-3-10)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314122
PNG
(3-[(4-chloro-2-cyclopropylbenzyl)amino]pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1C1CC1
Show InChI InChI=1S/C16H15ClN2O2/c17-12-4-3-11(14(7-12)10-1-2-10)8-19-15-9-18-6-5-13(15)16(20)21/h3-7,9-10,19H,1-2,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314130
PNG
(3-[(2-cyclopropyl-5-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1ccc(C2CC2)c(CNc2cnccc2C(O)=O)c1
Show InChI InChI=1S/C17H18N2O2/c1-11-2-5-14(12-3-4-12)13(8-11)9-19-16-10-18-7-6-15(16)17(20)21/h2,5-8,10,12,19H,3-4,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314139
PNG
(3-[(2,3-dihydro-1-benzofuran-2-ylmethyl)amino]pyri...)
Show SMILES OC(=O)c1ccncc1NCC1Cc2ccccc2O1
Show InChI InChI=1S/C15H14N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-6,9,11,17H,7-8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314141
PNG
(3-[(2,3-dihydro-1H-inden-1-ylmethylbenzyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCc2ccccc12
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-6-5-11-3-1-2-4-13(11)12/h1-4,7-8,10,12,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314152
PNG
(3-[(3,4-dihydro-2H-chromen-4-ylmethyl)amino]pyridi...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314152
PNG
(3-[(3,4-dihydro-2H-chromen-4-ylmethyl)amino]pyridi...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2ccccc12
Show InChI InChI=1S/C16H16N2O3/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314156
PNG
(3-{[(6-methyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES Cc1ccc2OCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-11-2-3-16-14(8-11)12(5-7-22-16)9-19-15-10-18-6-4-13(15)17(20)21/h2-4,6,8,10,12,19H,5,7,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314105
PNG
(3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314117
PNG
(3-[(4-chloro-2-hydroxybenzyl)amino]pyridine-4-carb...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1O
Show InChI InChI=1S/C13H11ClN2O3/c14-9-2-1-8(12(17)5-9)6-16-11-7-15-4-3-10(11)13(18)19/h1-5,7,16-17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314119
PNG
(3-[(4-bromobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314120
PNG
(3-[(4-methylbenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O2/c1-10-2-4-11(5-3-10)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314127
PNG
(3-{[(4-cyclopropylpyridin-3-yl)-methyl]amino}pyrid...)
Show SMILES OC(=O)c1ccncc1NCc1cnccc1C1CC1
Show InChI InChI=1S/C15H15N3O2/c19-15(20)13-4-6-17-9-14(13)18-8-11-7-16-5-3-12(11)10-1-2-10/h3-7,9-10,18H,1-2,8H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314128
PNG
(3-{[3-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314129
PNG
(3-[(2-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)16-10-11-20-13-17(16)21-12-14-6-4-5-9-18(14)24-15-7-2-1-3-8-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314132
PNG
(3-{[2-(phenylamino)benzyl]amino}pyridine-4-carboxy...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c23-19(24)16-10-11-20-13-18(16)21-12-14-6-4-5-9-17(14)22-15-7-2-1-3-8-15/h1-11,13,21-22H,12H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314133
PNG
(3-{[3-(cyclopropylmethoxy)benzyl]amino}pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C17H18N2O3/c20-17(21)15-6-7-18-10-16(15)19-9-13-2-1-3-14(8-13)22-11-12-4-5-12/h1-3,6-8,10,12,19H,4-5,9,11H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314134
PNG
(3-[(1-benzofuran-3-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1coc2ccccc12
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-8-13(12)17-7-10-9-20-14-4-2-1-3-11(10)14/h1-6,8-9,17H,7H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314136
PNG
(3-{[(5-methylfuran-2-yl)methyl]amino}pyridine-4-ca...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)o1
Show InChI InChI=1S/C12H12N2O3/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314137
PNG
(3-[(1-benzofuran-2-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1cc2ccccc2o1
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-7,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM50158791
PNG
(CHEMBL3786596 | US10179769, Example 42 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H22N2O2/c20-16(21)14-1-2-18-9-15(14)19-10-17-6-11-3-12(7-17)5-13(4-11)8-17/h1-2,9,11-13,19H,3-8,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314118
PNG
(3-[(2-aminobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES Nc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C13H13N3O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7,14H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314125
PNG
(3-[(1H-indol-7-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1cccc2cc[nH]c12
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314128
PNG
(3-{[3-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314128
PNG
(3-{[3-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314132
PNG
(3-{[2-(phenylamino)benzyl]amino}pyridine-4-carboxy...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c23-19(24)16-10-11-20-13-18(16)21-12-14-6-4-5-9-17(14)22-15-7-2-1-3-8-15/h1-11,13,21-22H,12H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314139
PNG
(3-[(2,3-dihydro-1-benzofuran-2-ylmethyl)amino]pyri...)
Show SMILES OC(=O)c1ccncc1NCC1Cc2ccccc2O1
Show InChI InChI=1S/C15H14N2O3/c18-15(19)12-5-6-16-9-13(12)17-8-11-7-10-3-1-2-4-14(10)20-11/h1-6,9,11,17H,7-8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314141
PNG
(3-[(2,3-dihydro-1H-inden-1-ylmethylbenzyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCc2ccccc12
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-6-5-11-3-1-2-4-13(11)12/h1-4,7-8,10,12,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314117
PNG
(3-[(4-chloro-2-hydroxybenzyl)amino]pyridine-4-carb...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1O
Show InChI InChI=1S/C13H11ClN2O3/c14-9-2-1-8(12(17)5-9)6-16-11-7-15-4-3-10(11)13(18)19/h1-5,7,16-17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314119
PNG
(3-[(4-bromobenzyl)amino]pyridine-4-carboxylic acid...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314121
PNG
(3-[(4-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-11-1-3-12(4-2-11)13-5-6-13/h1-4,7-8,10,13,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314123
PNG
(3-{[2-cyclopropyl-4-(trifluoromethyl)benzyl]amino}...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1C1CC1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N2O2/c18-17(19,20)12-4-3-11(14(7-12)10-1-2-10)8-22-15-9-21-6-5-13(15)16(23)24/h3-7,9-10,22H,1-2,8H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314129
PNG
(3-[(2-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)16-10-11-20-13-17(16)21-12-14-6-4-5-9-18(14)24-15-7-2-1-3-8-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM50153334
PNG
(CHEMBL3774545 | US10179769, Example 39 | US9611221...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)s1
Show InChI InChI=1S/C12H12N2O2S/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314136
PNG
(3-{[(5-methylfuran-2-yl)methyl]amino}pyridine-4-ca...)
Show SMILES Cc1ccc(CNc2cnccc2C(O)=O)o1
Show InChI InChI=1S/C12H12N2O3/c1-8-2-3-9(17-8)6-14-11-7-13-5-4-10(11)12(15)16/h2-5,7,14H,6H2,1H3,(H,15,16)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314140
PNG
(3-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)amino]p...)
Show SMILES OC(=O)c1ccncc1NCC1COc2ccccc2O1
Show InChI InChI=1S/C15H14N2O4/c18-15(19)11-5-6-16-8-12(11)17-7-10-9-20-13-3-1-2-4-14(13)21-10/h1-6,8,10,17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314148
PNG
(3-{[(7-cyclopropyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)C1CC1
Show InChI InChI=1S/C20H22N2O2/c23-20(24)17-8-9-21-12-19(17)22-11-16-3-1-2-14-6-7-15(10-18(14)16)13-4-5-13/h6-10,12-13,16,22H,1-5,11H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314154
PNG
(3-{[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314158
PNG
(3-{[(6-fluoro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(F)ccc12
Show InChI InChI=1S/C16H15FN2O3/c17-11-1-2-12-10(4-6-22-15(12)7-11)8-19-14-9-18-5-3-13(14)16(20)21/h1-3,5,7,9-10,19H,4,6,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314164
PNG
(3-{[(8-fluoro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2c(F)cccc12
Show InChI InChI=1S/C16H15FN2O3/c17-13-3-1-2-11-10(5-7-22-15(11)13)8-19-14-9-18-6-4-12(14)16(20)21/h1-4,6,9-10,19H,5,7-8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314123
PNG
(3-{[2-cyclopropyl-4-(trifluoromethyl)benzyl]amino}...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1C1CC1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N2O2/c18-17(19,20)12-4-3-11(14(7-12)10-1-2-10)8-22-15-9-21-6-5-13(15)16(23)24/h3-7,9-10,22H,1-2,8H2,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314189
PNG
(3-{[(5,6-dimethyl-1,2,3,4-tetrahydronaphthalen-1-y...)
Show SMILES Cc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1C
Show InChI InChI=1S/C19H22N2O2/c1-12-6-7-16-14(4-3-5-15(16)13(12)2)10-21-18-11-20-9-8-17(18)19(22)23/h6-9,11,14,21H,3-5,10H2,1-2H3,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314131
PNG
(3-{[3-(trifluoromethoxy)benzyl]amino}pyridine-4-ca...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314133
PNG
(3-{[3-(cyclopropylmethoxy)benzyl]amino}pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C17H18N2O3/c20-17(21)15-6-7-18-10-16(15)19-9-13-2-1-3-14(8-13)22-11-12-4-5-12/h1-3,6-8,10,12,19H,4-5,9,11H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314143
PNG
(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]a...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314144
PNG
(3-{[(1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES CC1(CNc2cnccc2C(O)=O)CCCc2ccccc12
Show InChI InChI=1S/C18H20N2O2/c1-18(9-4-6-13-5-2-3-7-15(13)18)12-20-16-11-19-10-8-14(16)17(21)22/h2-3,5,7-8,10-11,20H,4,6,9,12H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314145
PNG
(3-{[(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(F)cc12
Show InChI InChI=1S/C17H17FN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314149
PNG
(3-{[(5-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2c(F)cccc12
Show InChI InChI=1S/C17H17FN2O2/c18-15-6-2-4-12-11(3-1-5-13(12)15)9-20-16-10-19-8-7-14(16)17(21)22/h2,4,6-8,10-11,20H,1,3,5,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314151
PNG
(3-({[(1S)-5-fluoro-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2c(F)cccc12
Show InChI InChI=1S/C17H17FN2O2/c18-15-6-2-4-12-11(3-1-5-13(12)15)9-20-16-10-19-8-7-14(16)17(21)22/h2,4,6-8,10-11,20H,1,3,5,9H2,(H,21,22)/t11-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314156
PNG
(3-{[(6-methyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES Cc1ccc2OCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-11-2-3-16-14(8-11)12(5-7-22-16)9-19-15-10-18-6-4-13(15)17(20)21/h2-4,6,8,10,12,19H,5,7,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314158
PNG
(3-{[(6-fluoro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(F)ccc12
Show InChI InChI=1S/C16H15FN2O3/c17-11-1-2-12-10(4-6-22-15(12)7-11)8-19-14-9-18-5-3-13(14)16(20)21/h1-3,5,7,9-10,19H,4,6,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314190
PNG
(3-{[(6-{[6-(trifluoromethyl)pyridin-2-yl]oxy}-1,2,...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(Oc3cccc(n3)C(F)(F)F)ccc12
Show InChI InChI=1S/C23H20F3N3O3/c24-23(25,26)20-5-2-6-21(29-20)32-16-7-8-17-14(11-16)3-1-4-15(17)12-28-19-13-27-10-9-18(19)22(30)31/h2,5-11,13,15,28H,1,3-4,12H2,(H,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314131
PNG
(3-{[3-(trifluoromethoxy)benzyl]amino}pyridine-4-ca...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314146
PNG
(3-{[(7-fluoro-3,4-dihydronaphthalen-1-yl)methyl]am...)
Show SMILES OC(=O)c1ccncc1NCC1=CCCc2ccc(F)cc12
Show InChI InChI=1S/C17H15FN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h3-8,10,20H,1-2,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314171
PNG
(3-[(3,4-dihydro-2H-thiochromen-4-ylmethyl)amino]py...)
Show SMILES OC(=O)c1ccncc1NCC1CCSc2ccccc12
Show InChI InChI=1S/C16H16N2O2S/c19-16(20)13-5-7-17-10-14(13)18-9-11-6-8-21-15-4-2-1-3-12(11)15/h1-5,7,10-11,18H,6,8-9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314172
PNG
(3-({[(6-(3,3,3-trifluoropropoxy)-1,2,3,4-tetrahydr...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OCCC(F)(F)F)ccc12
Show InChI InChI=1S/C20H21F3N2O3/c21-20(22,23)7-9-28-15-4-5-16-13(10-15)2-1-3-14(16)11-25-18-12-24-8-6-17(18)19(26)27/h4-6,8,10,12,14,25H,1-3,7,9,11H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314122
PNG
(3-[(4-chloro-2-cyclopropylbenzyl)amino]pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1C1CC1
Show InChI InChI=1S/C16H15ClN2O2/c17-12-4-3-11(14(7-12)10-1-2-10)8-19-15-9-18-6-5-13(15)16(20)21/h3-7,9-10,19H,1-2,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314154
PNG
(3-{[(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314157
PNG
(3-({[(6-(propan-2-yloxy)-1,2,3,4-tetrahydronaphtha...)
Show SMILES CC(C)Oc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C20H24N2O3/c1-13(2)25-16-6-7-17-14(10-16)4-3-5-15(17)11-22-19-12-21-9-8-18(19)20(23)24/h6-10,12-13,15,22H,3-5,11H2,1-2H3,(H,23,24)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314161
PNG
(3-{[(6-chloro-1-hydroxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(Cl)ccc12
Show InChI InChI=1S/C17H17ClN2O2/c18-13-4-5-14-11(8-13)2-1-3-12(14)9-20-16-10-19-7-6-15(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314168
PNG
(3-{[(7-cyclopropyl-3,4-dihydro-2H-chromen-4-yl)met...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)C1CC1
Show InChI InChI=1S/C19H20N2O3/c22-19(23)16-5-7-20-11-17(16)21-10-14-6-8-24-18-9-13(12-1-2-12)3-4-15(14)18/h3-5,7,9,11-12,14,21H,1-2,6,8,10H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314178
PNG
(3-({[(4S)-7-cyclopropyl-3,4-dihydro-2H-chromen-4-y...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)C1CC1
Show InChI InChI=1S/C19H20N2O3/c22-19(23)16-5-7-20-11-17(16)21-10-14-6-8-24-18-9-13(12-1-2-12)3-4-15(14)18/h3-5,7,9,11-12,14,21H,1-2,6,8,10H2,(H,22,23)/t14-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314121
PNG
(3-[(4-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-11-1-3-12(4-2-11)13-5-6-13/h1-4,7-8,10,13,18H,5-6,9H2,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314134
PNG
(3-[(1-benzofuran-3-ylmethyl)amino]pyridine-4-carbo...)
Show SMILES OC(=O)c1ccncc1NCc1coc2ccccc12
Show InChI InChI=1S/C15H12N2O3/c18-15(19)12-5-6-16-8-13(12)17-7-10-9-20-14-4-2-1-3-11(10)14/h1-6,8-9,17H,7H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314142
PNG
(3-[(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)amino]...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314159
PNG
(3-{[(7-chloro-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(Cl)ccc12
Show InChI InChI=1S/C16H15ClN2O3/c17-11-1-2-12-10(4-6-22-15(12)7-11)8-19-14-9-18-5-3-13(14)16(20)21/h1-3,5,7,9-10,19H,4,6,8H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314130
PNG
(3-[(2-cyclopropyl-5-methylbenzyl)amino]pyridine-4-...)
Show SMILES Cc1ccc(C2CC2)c(CNc2cnccc2C(O)=O)c1
Show InChI InChI=1S/C17H18N2O2/c1-11-2-5-14(12-3-4-12)13(8-11)9-19-16-10-18-7-6-15(16)17(20)21/h2,5-8,10,12,19H,3-4,9H2,1H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314143
PNG
(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]a...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314144
PNG
(3-{[(1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES CC1(CNc2cnccc2C(O)=O)CCCc2ccccc12
Show InChI InChI=1S/C18H20N2O2/c1-18(9-4-6-13-5-2-3-7-15(13)18)12-20-16-11-19-10-8-14(16)17(21)22/h2-3,5,7-8,10-11,20H,4,6,9,12H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314160
PNG
(3-{[(6-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1(O)CCCc2cc(Cl)ccc12
Show InChI InChI=1S/C17H17ClN2O3/c18-12-3-4-14-11(8-12)2-1-6-17(14,23)10-20-15-9-19-7-5-13(15)16(21)22/h3-5,7-9,20,23H,1-2,6,10H2,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314162
PNG
(3-{[(7-phenyl-3,4-dihydro-2H-chromen-4-yl)methyl]a...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c25-22(26)19-8-10-23-14-20(19)24-13-17-9-11-27-21-12-16(6-7-18(17)21)15-4-2-1-3-5-15/h1-8,10,12,14,17,24H,9,11,13H2,(H,25,26)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM50158790
PNG
(CHEMBL3787556 | US10179769, Example 80 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C23H22N2O3/c26-23(27)21-11-12-24-15-22(21)25-14-17-6-4-5-16-13-19(9-10-20(16)17)28-18-7-2-1-3-8-18/h1-3,7-13,15,17,25H,4-6,14H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314176
PNG
(3-({[(4S)-7-phenyl-3,4-dihydro-2H-chromen-4-yl]met...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c25-22(26)19-8-10-23-14-20(19)24-13-17-9-11-27-21-12-16(6-7-18(17)21)15-4-2-1-3-5-15/h1-8,10,12,14,17,24H,9,11,13H2,(H,25,26)/t17-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM50158791
PNG
(CHEMBL3786596 | US10179769, Example 42 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H22N2O2/c20-16(21)14-1-2-18-9-15(14)19-10-17-6-11-3-12(7-17)5-13(4-11)8-17/h1-2,9,11-13,19H,3-8,10H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314143
PNG
(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]a...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C17H18N2O2/c20-17(21)15-8-9-18-11-16(15)19-10-13-6-3-5-12-4-1-2-7-14(12)13/h1-2,4,7-9,11,13,19H,3,5-6,10H2,(H,20,21)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314144
PNG
(3-{[(1-methyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES CC1(CNc2cnccc2C(O)=O)CCCc2ccccc12
Show InChI InChI=1S/C18H20N2O2/c1-18(9-4-6-13-5-2-3-7-15(13)18)12-20-16-11-19-10-8-14(16)17(21)22/h2-3,5,7-8,10-11,20H,4,6,9,12H2,1H3,(H,21,22)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314155
PNG
(3-({[(1S)-6-methoxy-1,2,3,4-tetrahydronaphthalen-1...)
Show SMILES COc1ccc2[C@@H](CNc3cnccc3C(O)=O)CCCc2c1
Show InChI InChI=1S/C18H20N2O3/c1-23-14-5-6-15-12(9-14)3-2-4-13(15)10-20-17-11-19-8-7-16(17)18(21)22/h5-9,11,13,20H,2-4,10H2,1H3,(H,21,22)/t13-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314165
PNG
(3-{[(7-chloro-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(Cl)cc12
Show InChI InChI=1S/C17H17ClN2O2/c18-13-5-4-11-2-1-3-12(15(11)8-13)9-20-16-10-19-7-6-14(16)17(21)22/h4-8,10,12,20H,1-3,9H2,(H,21,22)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314167
PNG
(3-{[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES COc1cccc2C(CNc3cnccc3C(O)=O)CCCc12
Show InChI InChI=1S/C18H20N2O3/c1-23-17-7-3-5-13-12(4-2-6-14(13)17)10-20-16-11-19-9-8-15(16)18(21)22/h3,5,7-9,11-12,20H,2,4,6,10H2,1H3,(H,21,22)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314131
PNG
(3-{[3-(trifluoromethoxy)benzyl]amino}pyridine-4-ca...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-3-1-2-9(6-10)7-19-12-8-18-5-4-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314132
PNG
(3-{[2-(phenylamino)benzyl]amino}pyridine-4-carboxy...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c23-19(24)16-10-11-20-13-18(16)21-12-14-6-4-5-9-17(14)22-15-7-2-1-3-8-15/h1-11,13,21-22H,12H2,(H,23,24)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM50158791
PNG
(CHEMBL3786596 | US10179769, Example 42 | US9611221...)
Show SMILES OC(=O)c1ccncc1NCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C17H22N2O2/c20-16(21)14-1-2-18-9-15(14)19-10-17-6-11-3-12(7-17)5-13(4-11)8-17/h1-2,9,11-13,19H,3-8,10H2,(H,20,21)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314150
PNG
(3-{[(5-fluoro-1-hydroxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES OC(=O)c1ccncc1NCC1(O)CCCc2c(F)cccc12
Show InChI InChI=1S/C17H17FN2O3/c18-14-5-1-4-13-11(14)3-2-7-17(13,23)10-20-15-9-19-8-6-12(15)16(21)22/h1,4-6,8-9,20,23H,2-3,7,10H2,(H,21,22)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314166
PNG
(3-{[(7-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)me...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C23H22N2O2/c26-23(27)20-11-12-24-15-22(20)25-14-19-8-4-7-17-9-10-18(13-21(17)19)16-5-2-1-3-6-16/h1-3,5-6,9-13,15,19,25H,4,7-8,14H2,(H,26,27)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314179
PNG
(3-({[6-(2-phenylethoxy)-1,2,3,4-tetrahydronaphthal...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OCCc3ccccc3)ccc12
Show InChI InChI=1S/C25H26N2O3/c28-25(29)23-11-13-26-17-24(23)27-16-20-8-4-7-19-15-21(9-10-22(19)20)30-14-12-18-5-2-1-3-6-18/h1-3,5-6,9-11,13,15,17,20,27H,4,7-8,12,14,16H2,(H,28,29)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314188
PNG
(3-{[(5-fluoro-6-methoxy-1,2,3,4-tetrahydronaphthal...)
Show SMILES COc1ccc2C(CNc3cnccc3C(O)=O)CCCc2c1F
Show InChI InChI=1S/C18H19FN2O3/c1-24-16-6-5-12-11(3-2-4-13(12)17(16)19)9-21-15-10-20-8-7-14(15)18(22)23/h5-8,10-11,21H,2-4,9H2,1H3,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314105
PNG
(3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314116
PNG
(3-[(4-chloro-2-methoxybenzyl)amino]pyridine-4-carb...)
Show SMILES COc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O3/c1-20-13-6-10(15)3-2-9(13)7-17-12-8-16-5-4-11(12)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314133
PNG
(3-{[3-(cyclopropylmethoxy)benzyl]amino}pyridine-4-...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(OCC2CC2)c1
Show InChI InChI=1S/C17H18N2O3/c20-17(21)15-6-7-18-10-16(15)19-9-13-2-1-3-14(8-13)22-11-12-4-5-12/h1-3,6-8,10,12,19H,4-5,9,11H2,(H,20,21)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314148
PNG
(3-{[(7-cyclopropyl-1,2,3,4-tetrahydronaphthalen-1-...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2ccc(cc12)C1CC1
Show InChI InChI=1S/C20H22N2O2/c23-20(24)17-8-9-21-12-19(17)22-11-16-3-1-2-14-6-7-15(10-18(14)16)13-4-5-13/h6-10,12-13,16,22H,1-5,11H2,(H,23,24)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314153
PNG
(3-{[(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-y...)
Show SMILES CC1(C)CCC(CNc2cnccc2C(O)=O)c2ccccc12
Show InChI InChI=1S/C19H22N2O2/c1-19(2)9-7-13(14-5-3-4-6-16(14)19)11-21-17-12-20-10-8-15(17)18(22)23/h3-6,8,10,12-13,21H,7,9,11H2,1-2H3,(H,22,23)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314174
PNG
(3-({[(6-(cyclopropylmethoxy)-1,2,3,4-tetrahydronap...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OCC3CC3)ccc12
Show InChI InChI=1S/C21H24N2O3/c24-21(25)19-8-9-22-12-20(19)23-11-16-3-1-2-15-10-17(6-7-18(15)16)26-13-14-4-5-14/h6-10,12,14,16,23H,1-5,11,13H2,(H,24,25)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314175
PNG
(3{[(1-methyl-1,2,3,4-tetrahydroquinolin-4-yl)methy...)
Show SMILES CN1CCC(CNc2cnccc2C(O)=O)c2ccccc12
Show InChI InChI=1S/C17H19N3O2/c1-20-9-7-12(13-4-2-3-5-16(13)20)10-19-15-11-18-8-6-14(15)17(21)22/h2-6,8,11-12,19H,7,9-10H2,1H3,(H,21,22)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314177
PNG
(3-({[(4S)-7-(3-fluorophenyl)-3,4-dihydro-2H-chrome...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1cccc(F)c1
Show InChI InChI=1S/C22H19FN2O3/c23-17-3-1-2-14(10-17)15-4-5-18-16(7-9-28-21(18)11-15)12-25-20-13-24-8-6-19(20)22(26)27/h1-6,8,10-11,13,16,25H,7,9,12H2,(H,26,27)/t16-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314180
PNG
(3-({[6-(2,2,2-trifluoroethoxy)-1,2,3,4-tetrahydron...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OCC(F)(F)F)ccc12
Show InChI InChI=1S/C19H19F3N2O3/c20-19(21,22)11-27-14-4-5-15-12(8-14)2-1-3-13(15)9-24-17-10-23-7-6-16(17)18(25)26/h4-8,10,13,24H,1-3,9,11H2,(H,25,26)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314181
PNG
(3-({[7-(2-cyclopropylethyl)-3,4-dihydro-2H-chromen...)
Show SMILES OC(=O)c1ccncc1NCC1CCOc2cc(CCC3CC3)ccc12
Show InChI InChI=1S/C21H24N2O3/c24-21(25)18-7-9-22-13-19(18)23-12-16-8-10-26-20-11-15(5-6-17(16)20)4-3-14-1-2-14/h5-7,9,11,13-14,16,23H,1-4,8,10,12H2,(H,24,25)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314187
PNG
(3-({[6-(3,3,3-trifluoropropoxy)-1,2,3,4-tetrahydro...)
Show SMILES OC(=O)c1ccnnc1NCC1CCCc2cc(OCCC(F)(F)F)ccc12
Show InChI InChI=1S/C19H20F3N3O3/c20-19(21,22)7-9-28-14-4-5-15-12(10-14)2-1-3-13(15)11-23-17-16(18(26)27)6-8-24-25-17/h4-6,8,10,13H,1-3,7,9,11H2,(H,23,25)(H,26,27)
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n/an/a 550n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314129
PNG
(3-[(2-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)16-10-11-20-13-17(16)21-12-14-6-4-5-9-18(14)24-15-7-2-1-3-8-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314105
PNG
(3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314170
PNG
(3-{[(5-phenoxy-1,2,3,4-tetrahydronaphthalen-1-yl)m...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2c(Oc3ccccc3)cccc12
Show InChI InChI=1S/C23H22N2O3/c26-23(27)20-12-13-24-15-21(20)25-14-16-6-4-10-19-18(16)9-5-11-22(19)28-17-7-2-1-3-8-17/h1-3,5,7-9,11-13,15-16,25H,4,6,10,14H2,(H,26,27)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314182
PNG
(3-({[6-(trifluoromethoxy)-1,2,3,4-tetrahydronaphth...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2cc(OC(F)(F)F)ccc12
Show InChI InChI=1S/C18H17F3N2O3/c19-18(20,21)26-13-4-5-14-11(8-13)2-1-3-12(14)9-23-16-10-22-7-6-15(16)17(24)25/h4-8,10,12,23H,1-3,9H2,(H,24,25)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314169
PNG
(3-({[(5-(cyclopropylmethoxy)-1,2,3,4-tetrahydronap...)
Show SMILES OC(=O)c1ccncc1NCC1CCCc2c(OCC3CC3)cccc12
Show InChI InChI=1S/C21H24N2O3/c24-21(25)18-9-10-22-12-19(18)23-11-15-3-1-5-17-16(15)4-2-6-20(17)26-13-14-7-8-14/h2,4,6,9-10,12,14-15,23H,1,3,5,7-8,11,13H2,(H,24,25)
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314186
PNG
(3-({[(1S)-6-(3,3,3-trifluoropropoxy)-1,2,3,4-tetra...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2cc(OCCC(F)(F)F)ccc12
Show InChI InChI=1S/C20H21F3N2O3/c21-20(22,23)7-9-28-15-4-5-16-13(10-15)2-1-3-14(16)11-25-18-12-24-8-6-17(18)19(26)27/h4-6,8,10,12,14,25H,1-3,7,9,11H2,(H,26,27)/t14-/m1/s1
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UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314147
PNG
(3-{[(5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-y...)
Show SMILES Cc1cc(C)c2CCCC(CNc3cnccc3C(O)=O)c2c1
Show InChI InChI=1S/C19H22N2O2/c1-12-8-13(2)15-5-3-4-14(17(15)9-12)10-21-18-11-20-7-6-16(18)19(22)23/h6-9,11,14,21H,3-5,10H2,1-2H3,(H,22,23)
PDB

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UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314183
PNG
(3-({[(4S)-7-(4-fluorophenyl)-3,4-dihydro-2H-chrome...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C22H19FN2O3/c23-17-4-1-14(2-5-17)15-3-6-18-16(8-10-28-21(18)11-15)12-25-20-13-24-9-7-19(20)22(26)27/h1-7,9,11,13,16,25H,8,10,12H2,(H,26,27)/t16-/m1/s1
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UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314184
PNG
(3-({[(4S)-7-(2-fluorophenyl)-3,4-dihydro-2H- chrom...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCOc2cc(ccc12)-c1ccccc1F
Show InChI InChI=1S/C22H19FN2O3/c23-19-4-2-1-3-16(19)14-5-6-17-15(8-10-28-21(17)11-14)12-25-20-13-24-9-7-18(20)22(26)27/h1-7,9,11,13,15,25H,8,10,12H2,(H,26,27)/t15-/m1/s1
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
jmjd2c


(Homo sapiens (Human))
BDBM314185
PNG
(3-({[(1S)-6-(2-cyclopropylethoxy)-1,2,3,4-tetrahyd...)
Show SMILES OC(=O)c1ccncc1NC[C@H]1CCCc2cc(OCCC3CC3)ccc12
Show InChI InChI=1S/C22H26N2O3/c25-22(26)20-8-10-23-14-21(20)24-13-17-3-1-2-16-12-18(6-7-19(16)17)27-11-9-15-4-5-15/h6-8,10,12,14-15,17,24H,1-5,9,11,13H2,(H,25,26)/t17-/m1/s1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%